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Data / Federal rules / Drug Enforcement Administration

Drug Enforcement Administration: 95 rules and proposed rules since January 2024

56 final rules and 39 proposed rules since January 3, 2024, 13 of them marked significant. 2 are open for comment now. Common topics: drug traffic control, administrative practice and procedure, reporting and recordkeeping requirements, imports, exports.

SpecStream is the live web data engine for teams and agents. It reads every rule and proposed rule in the Federal Register each morning, and this page is that reading. Name your industry once and new rules, comment deadlines and effective dates arrive in your sheet, CRM, Slack or agent as they are published.

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Every document, newest first

DocumentTypePublished
Schedules of Controlled Substances: Temporary Placement of 7- Hydroxymitragynine and Mitragynine Pseudoindoxyl Above a Specified Threshold in Schedule I
2026-20943
Proposed ruleOct 14
Schedules of Controlled Substances: Temporary Placement of MGM-15 and MGM-16 in Schedule I
2026-20942
Proposed ruleOct 14
Schedules of Controlled Substances; Removal of Exemption Status for Inactive Butalbital Products
2026-20757
Final ruleOct 9
Schedules of Controlled Substances: Placement of O-Desmethyltramadol in Schedule I; Correction
2026-20748
Final ruleOct 9
Extension of Reexportation Period.
2026-20084
Proposed ruleOct 1
Schedules of Controlled Substances: Placement of 4-Hydroxy-N,N-Diisopropyltryptamine (4-OH-DiPT), 5-Methoxy-alpha-Methyltryptamine (5-MeO-AMT), 5-Methoxy-N-Methyl-N-Isopropyltryptamine (5-MeO-MiPT), 5-Methoxy-N,N-Diethyltryptamine (5-MeO-DET), and N,N-Diisopropyltryptamine (DiPT) Into Schedule I
2026-19400
Proposed ruleSep 23
Schedules of Controlled Substances: Placement of Diphenidine in Schedule I
2026-19231
Final ruleSep 21
Schedules of Controlled Substances: Placement of Cipepofol in Schedule IV
2026-17536
Final ruleAug 27
Schedules of Controlled Substances: Temporary Placement of 5,6-Dichloro Brorphine, 5,6-Dichloro Desmethylchlorphine, N-Propionitrile Chlorphine, and Spirochlorphine in Schedule I of the Controlled Substances Act
2026-17531
Final ruleAug 27
Schedules of Controlled Substances: Temporary Placement of Mitragynine Pseudoindoxyl, MGM-15, and MGM-16 in Schedule I
2026-17429
Final ruleAug 26
Schedules of Controlled Substances: Temporary Placement of O-Desmethyltramadol in Schedule I
2026-16413
Final ruleAug 12
Schedules of Controlled Substances: Rescheduling of Suvorexant, Lemborexant, and Daridorexant From Schedule IV Into Schedule V
2026-16375
Proposed ruleAug 11
Amendment to 3,4-MDP-2-P Methyl Glycidic Acid, a List I Chemical
2026-15624
Proposed ruleAug 3
Designation of Phenethyl Halides as List I Chemicals
2026-13825
Proposed ruleJul 9
Schedules of Controlled Substances: Placement of Tianeptine in Schedule I
2026-13821
Proposed ruleJul 8
Schedules of Controlled Substances: Temporary Placement of Mitragynine Pseudoindoxyl, MGM-15, and MGM-16 in Schedule I
2026-13581
Proposed ruleJul 6
Schedules of Controlled Substance: Temporary Placement of 7-Hydroxymitragynine Above a Specified Threshold in Schedule I
2026-13580
Proposed ruleJul 6
Schedules of Controlled Substances: Temporary Placement of 5,6- Dichloro Brorphine, 5,6-Dichloro Desmethylchlorphine, N-Propionitrile Chlorphine, and Spirochlorphine in Schedule I of the Controlled Substances Act
2026-13364
Proposed ruleJul 1
Schedules of Controlled Substances: Temporary Placement of O-Desmethyltramadol in Schedule I
2026-12654
Final ruleJun 24
Schedules of Controlled Substances: Placement of Bromazolam in Schedule I; Correction
2026-12653
Final ruleJun 24
Implementation of the Substance Use-Disorder Prevention That Promotes Opioid Recovery and Treatment for Patients and Communities Act of 2018: Dispensing and Administering Controlled Substances for Medication-Assisted Treatment
2026-11526 · significant
Final ruleJun 9
Schedules of Controlled Substances: Placement of Diphenidine in Schedule I
2026-10380
Proposed ruleMay 26
Schedules of Controlled Substances; Removal of Exemption Status for Inactive Butalbital Products
2026-10379
Proposed ruleMay 26
Schedules of Controlled Substances: Temporary Placement of 2-Fluorodeschloroketamine in Schedule I
2026-10253
Final ruleMay 22
Revision of Applications for Manufacturing and Procurement Quotas
2026-10128 · significant
Proposed ruleMay 20
Schedules of Controlled Substances: Placement of CUMYL-PEGACLONE in Schedule I
2026-09566
Final ruleMay 13
Specific Listing for Hexahydrocannabinol, A Currently Controlled Schedule I Substance
2026-08595
Final ruleMay 4
Schedules of Controlled Substances: Placement of 4F-MDMB-BUTICA, ADB-4en-PINACA, 5F-EDMB-PICA, and MMB-FUBICA in Schedule I
2026-08517
Final ruleMay 1
Schedules of Controlled Substances: Rescheduling of Marijuana; Withdrawal
2026-08178
Proposed ruleApr 28
Schedules of Controlled Substances: Rescheduling of Marijuana
2026-08177
Proposed ruleApr 28
Schedules of Controlled Substances: Rescheduling of Food and Drug Administration Approved Products Containing Marijuana From Schedule I to Schedule III; Corresponding Change to Permit Requirements
2026-08176
Final ruleApr 28
Schedules of Controlled Substances: Placement of MDMB-4en-PINACA in Schedule I
2026-08104
Final ruleApr 24
Designation of P2P Methyl Glycidic Acid as a List I Chemical
2026-06523
Final ruleApr 3
Registering Emergency Medical Services Agencies Under the Protecting Patient Access to Emergency Medications Act of 2017
C1-2026-02288 · significant
Final ruleApr 1
Schedules of Controlled Substances: Placement of 3-Methoxyphencyclidine (1-(1-(3-Methoxyphenyl)cyclohexyl)piperidine) in Schedule I
2026-05618
Final ruleMar 23
Ordering Schedule I and II Controlled Substances Using DEA Form 222; Technical Amendments
2026-05482
Final ruleMar 20
Schedules of Controlled Substances: Temporary Placement of Bromazolam in Schedule I
2026-05064
Final ruleMar 16
Designation of Propionyl Chloride as a List I Chemical
2026-04657
Final ruleMar 10
Schedules of Controlled Substances: Placement of Clonazolam, Diclazepam, Etizolam, Flualprazolam, and Flubromazolam in Schedule I of the Controlled Substances Act
2026-04112
Final ruleMar 2
Registering Emergency Medical Services Agencies Under the Protecting Patient Access to Emergency Medications Act of 2017
2026-02288 · significant
Final ruleFeb 5
Schedules of Controlled Substances: Temporary Placement of 2-Fluorodeschloroketamine in Schedule I
2026-00954
Proposed ruleJan 20
Definition of “Cannabimimetic Agents” and Assignment of an Administration Controlled Substances Code Number for All “Cannabimimetic Agents”
2026-00907
Final ruleJan 20
Schedules of Controlled Substances: Placement of 4-Fluoroamphetamine in Schedule I
2026-00633
Final ruleJan 15
Schedules of Controlled Substances: Placement of N-Pyrrolidino Metonitazene and N-Pyrrolidino Protonitazene in Schedule I
2026-00362
Final ruleJan 12
Fourth Temporary Extension of COVID-19 Telemedicine Flexibilities for Prescription of Controlled Medications
2025-24123 · significant
Final ruleDec 31, 2025
Schedules of Controlled Substances: Placement of N-Desethyl Isotonitazene and N-Piperidinyl Etonitazene in Schedule I
2025-23717
Final ruleDec 23, 2025
Schedules of Controlled Substances: Placement of 4F-MDMB-BUTICA, ADB-4en-PINACA, 5F-EDMB-PICA, and MMB-FUBICA in Schedule I
2025-22963
Proposed ruleDec 16, 2025
Schedules of Controlled Substances: Extension of Temporary Placement of 4F-MDMB-BUTICA, ADB-4en-PINACA, 5F-EDMB-PICA, and MMB-FUBICA in Schedule I of the Controlled Substances Act
2025-22960
Final ruleDec 16, 2025
Schedules of Controlled Substances: Temporary Placement of Bromazolam in Schedule I
2025-22763
Proposed ruleDec 15, 2025
Schedules of Controlled Substances: Extension of Temporary Placement of MDMB-4en-PINACA in Schedule I of the Controlled Substances Act
2025-22540
Final ruleDec 11, 2025
Schedules of Controlled Substances: Extension of Temporary Placement of CUMYL-PEGACLONE in Schedule I of the Controlled Substances Act
2025-22496
Final ruleDec 11, 2025
Schedules of Controlled Substances: Placement of CUMYL-PEGACLONE in Schedule I
2025-22495
Proposed ruleDec 11, 2025
Schedules of Controlled Substances: Placement of 4-Chloromethcathinone in Schedule I
2025-20004
Final ruleNov 17, 2025
Schedules of Controlled Substances: Temporary Placement of Ethyleneoxynitazene, Methylenedioxynitazene, 5-Methyl Etodesnitazene, N-Desethyl Etonitazene, N-Desethyl Protonitazene, N,N-Dimethylamino Etonitazene, and N-Pyrrolidino Isotonitazene in Schedule I
2025-19542
Final ruleOct 15, 2025
Designation of P2P Methyl Glycidic Acid as a List I Chemical
2025-19384
Proposed ruleOct 2, 2025
Specific Listing for 1-boc-4-piperidone, a Currently Controlled List I Chemical
2025-19349
Final ruleOct 2, 2025
Schedules of Controlled Substances: Placement of MDMB-4en-PINACA in Schedule I
2025-19348
Proposed ruleOct 2, 2025
Controlled Substances Ordering System (CSOS) Modernization
2025-19325
Final ruleOct 2, 2025
Requiring Online Submission of Applications for and Renewals of DEA Registration: Technical Correction
2025-19292
Final ruleOct 2, 2025
Schedules of Controlled Substances: Placement of Seven Specific Fentanyl-Related Substances in Schedule I
2025-18103
Final ruleSep 18, 2025
Schedules of Controlled Substances: Temporary Placement of N-pyrrolidino metonitazene and N-pyrrolidino protonitazene in Schedule I
2025-15566
Final ruleAug 15, 2025
Specific Listing for Dipentylone, a Currently Controlled Schedule I Substance
2025-15177
Final ruleAug 8, 2025
Schedules of Controlled Substances: Extension of Temporary Placement of Clonazolam, Diclazepam, Etizolam, Flualprazolam, and Flubromazolam in Schedule I of the Controlled Substances Act
2025-14037
Final ruleJul 25, 2025
Schedules of Controlled Substances: Placement of Clonazolam, Diclazepam, Etizolam, Flualprazolam, and Flubromazolam in Schedule I of the Controlled Substances Act
2025-14022
Proposed ruleJul 25, 2025
Schedules of Controlled Substances: Temporary Placement of Seven Benzimidazole-Opioids in Schedule I
2025-11462
Proposed ruleJun 26, 2025
Schedules of Controlled Substances: Placement of 3-Methoxyphencyclidine (1-[1-(3-methoxyphenyl)cyclohexyl]piperidine) in Schedule I
2025-10503
Proposed ruleJun 10, 2025
Schedules of Controlled Substances: Placement of Three Specific Fentanyl-Related Substances in Schedule I
2025-10372
Proposed ruleJun 10, 2025
Schedules of Controlled Substances: Placement of 2-Methyl AP-237 in Schedule I; Correction
2025-09989
Final ruleJun 3, 2025
Schedules of Controlled Substances: Placement of 4-Fluoroamphetamine in Schedule I
2025-09988
Proposed ruleJun 3, 2025
Designation of Propionyl Chloride as a List I Chemical
2025-09983
Proposed ruleJun 3, 2025
Expansion of Buprenorphine Treatment via Telemedicine Encounter and Continuity of Care via Telemedicine for Veterans Affairs Patients
2025-05007 · significant
Final ruleMar 24, 2025
Expansion of Buprenorphine Treatment via Telemedicine Encounter and Continuity of Care via Telemedicine for Veterans Affairs Patients
2025-02793 · significant
Final ruleFeb 19, 2025
Special Registrations for Telemedicine and Limited State Telemedicine Registrations
2025-01099 · significant
Proposed ruleJan 17, 2025
Expansion of Buprenorphine Treatment via Telemedicine Encounter
2025-01049 · significant
Final ruleJan 17, 2025
Continuity of Care via Telemedicine for Veterans Affairs Patients
2025-01044 · significant
Final ruleJan 17, 2025
Schedules of Controlled Substances: Extension of Temporary Placement of Seven Specific Fentanyl-Related Substances in Schedule I of the Controlled Substances Act
2024-31130
Final ruleDec 30, 2024
Schedules of Controlled Substances: Placement of Seven Specific Fentanyl-Related Substances in Schedule I
2024-30798
Proposed ruleDec 30, 2024
Schedules of Controlled Substances: Placement of 4-Chloromethcathinone in Schedule I
2024-30359
Proposed ruleDec 30, 2024
Third Temporary Extension of COVID-19 Telemedicine Flexibilities for Prescription of Controlled Medications
2024-27018 · significant
Final ruleNov 19, 2024
Possible Control of Phenethyl Bromide as a List I Chemical
2024-24616
Proposed ruleOct 28, 2024
Schedules of Controlled Substances: Placement of Butonitazene, Flunitazene, and Metodesnitazene Substances in Schedule I
2024-24635
Final ruleOct 25, 2024
Schedules of Controlled Substances: Placement of Ethylphenidate in Schedule I
2024-24083
Final ruleOct 22, 2024
Schedules of Controlled Substances: Temporary Placement of N-Pyrrolidino Metonitazene and N-Pyrrolidino Protonitazene in Schedule I
2024-21058
Proposed ruleSep 17, 2024
Schedules of Controlled Substances: Rescheduling of Marijuana
2024-19370 · significant
Proposed ruleAug 29, 2024
Schedules of Controlled Substances: Placement of Zuranolone in Schedule IV
2024-18087
Final ruleAug 14, 2024
Schedules of Controlled Substances: Temporary Placement of N-Desethyl Isotonitazene and N-Piperidinyl Etonitazene in Schedule I
2024-16391
Final ruleJul 29, 2024
Announcement of Stayed Hearing: Schedules of Controlled Substances: Placement of 2,5-dimethoxy-4-iodoamphetamine (DOI) and 2,5-dimethoxy-4-chloroamphetamine (DOC) in Schedule I
2024-12504
Proposed ruleJun 7, 2024
Schedules of Controlled Substances: Rescheduling of Marijuana
2024-11137
Proposed ruleMay 21, 2024
Schedules of Controlled Substances: Placement of Butonitazene, Flunitazene, and Metodesnitazene Substances in Schedule I
2024-07694
Proposed ruleApr 11, 2024
Schedules of Controlled Substances: Extension of Temporary Placement of Butonitazene, Flunitazene, and Metodesnitazene in Schedule I of the Controlled Substances Act
2024-07689
Final ruleApr 11, 2024
Schedules of Controlled Substances: Placement of Etodesnitazene, N-Pyrrolidino Etonitazene, and Protonitazene in Schedule I
2024-07684
Final ruleApr 11, 2024
Announcement of Hearing: Schedules of Controlled Substances: Placement of 2,5-dimethoxy-4-iodoamphetamine (DOI) and 2,5-dimethoxy-4-chloroamphetamine (DOC) inSchedule I
2024-07473
Proposed ruleApr 9, 2024
Schedules of Controlled Substances: Placement of 2-Methyl AP-237 in Schedule I
2024-05543
Final ruleMar 15, 2024
Conforming Amendment Regarding the Veterinary Medicine Mobility Act of 2014
2024-02322 · significant
Final ruleFeb 8, 2024
Controlled Substance Destruction Alternatives to Incineration; Extension of Comment Period
2023-28964
Proposed ruleJan 3, 2024

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Read from the Federal Register API, last updated 2026-10-23. The document on federalregister.gov is the official record; dates and dockets can change through later corrections. Free to reuse with credit to SpecStream under CC BY 4.0.