Data / Federal rules / 2025-19325

Controlled Substances Ordering System (CSOS) Modernization

The Drug Enforcement Administration published this final rule in the Federal Register on October 2, 2025. It took effect on November 3, 2025.

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What the agency says

This rule is amending the Drug Enforcement Administration's (DEA) regulations to conform to the Controlled Substances Ordering System (CSOS) modernization effort by requiring all CSOS enrollment applications and supporting materials to be submitted through the Diversion Control Division secure online portal. These amendments improve the enrollment process by aligning it with DEA's current requirements for other online form submissions. The online submission of enrollment applications and supporting material through the secure online portal increases the efficiency of the enrollment, modification, and revocation processes, and ensures DEA's receipt of accurate documentation in a more timely and organized manner.

Key facts

Document number: 2025-19325
Type: Final rule
Action: Final rule
Agency: Justice Department; Drug Enforcement Administration
Published: October 2, 2025
Takes effect: November 3, 2025
Dates: This Final Rule is effective November 3, 2025.
Docket: Docket No. DEA-732
Regulation ID (RIN): 1117-AB79
Code of Federal Regulations: 21 CFR 1311
Topics: Administrative practice and procedure; Drug traffic control; Prescription drugs; Reporting and recordkeeping requirements
Pages: 16

The document on federalregister.gov PDF

Other documents from the Drug Enforcement Administration

Document	Type	Published
Schedules of Controlled Substances: Temporary Placement of 7- Hydroxymitragynine and Mitragynine Pseudoindoxyl Above a Specified Threshold in Schedule I 2026-20943	Proposed rule	Oct 14
Schedules of Controlled Substances: Temporary Placement of MGM-15 and MGM-16 in Schedule I 2026-20942	Proposed rule	Oct 14
Schedules of Controlled Substances; Removal of Exemption Status for Inactive Butalbital Products 2026-20757	Final rule	Oct 9
Schedules of Controlled Substances: Placement of O-Desmethyltramadol in Schedule I; Correction 2026-20748	Final rule	Oct 9
Extension of Reexportation Period. 2026-20084	Proposed rule	Oct 1
Schedules of Controlled Substances: Placement of 4-Hydroxy-N,N-Diisopropyltryptamine (4-OH-DiPT), 5-Methoxy-alpha-Methyltryptamine (5-MeO-AMT), 5-Methoxy-N-Methyl-N-Isopropyltryptamine (5-MeO-MiPT), 5-Methoxy-N,N-Diethyltryptamine (5-MeO-DET), and N,N-Diisopropyltryptamine (DiPT) Into Schedule I 2026-19400	Proposed rule	Sep 23
Schedules of Controlled Substances: Placement of Diphenidine in Schedule I 2026-19231	Final rule	Sep 21
Schedules of Controlled Substances: Placement of Cipepofol in Schedule IV 2026-17536	Final rule	Aug 27

Everything from the Drug Enforcement Administration · Rules on administrative practice and procedure · Rules on drug traffic control · Rules on prescription drugs · Published in October 2025

Read from the Federal Register API, last updated 2026-10-23. The document on federalregister.gov is the official record; dates and dockets can change through later corrections. Free to reuse with credit to SpecStream under CC BY 4.0.