Data / Federal rules / 2025-22495
Schedules of Controlled Substances: Placement of CUMYL-PEGACLONE in Schedule I
The Drug Enforcement Administration published this proposed rule in the Federal Register on December 11, 2025. Comments closed on January 12, 2026.
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What the agency says
The Drug Enforcement Administration proposes placing the substance CUMYL-PEGACLONE (SGT-151; 5-pentyl-2-(2-phenylpropan-2- yl)pyrido[4,3-b]indol-1-one), including its salts, isomers (including optical, positional, and geometric isomers), and salts of isomers, in schedule I of the Controlled Substances Act. CUMYL-PEGACLONE was temporarily scheduled in an order dated December 12, 2023. This action is being taken, in part, to enable the United States to meet its obligations under the 1971 Convention on Psychotropic Substances. If finalized, this action would make permanent the existing regulatory controls and administrative, civil, and criminal sanctions applicable to schedule I controlled substances on persons who handle (manufacture, distribute, reverse distribute, import, export, engage in research, conduct instructional activities or chemical analysis with, or possess) or propose to handle CUMYL-PEGACLONE.
Key facts
- Document number
- 2025-22495
- Type
- Proposed rule
- Action
- Notice of proposed rulemaking
- Agency
- Justice Department; Drug Enforcement Administration
- Published
- December 11, 2025
- Comments due
- January 12, 2026
- Dates
- Comments must be submitted electronically or postmarked on or before January 12, 2026. The electronic Federal Docket Management System will not accept comments after 11:59 p.m. Eastern Time on the last day of the comment period.
- Docket
- Docket No. DEA-1511
- Code of Federal Regulations
- 21 CFR 1308
- Topics
- Administrative practice and procedure; Drug traffic control; Reporting and recordkeeping requirements
- Pages
- 8
Other documents from the Drug Enforcement Administration
Everything from the Drug Enforcement Administration · Rules on administrative practice and procedure · Rules on drug traffic control · Rules on reporting and recordkeeping requirements · Published in December 2025
Read from the Federal Register API, last updated 2026-10-23. The document on federalregister.gov is the official record; dates and dockets can change through later corrections. Free to reuse with credit to SpecStream under CC BY 4.0.