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Data / Federal rules / 2025-10372

Schedules of Controlled Substances: Placement of Three Specific Fentanyl-Related Substances in Schedule I

The Drug Enforcement Administration published this proposed rule in the Federal Register on June 10, 2025. Comments closed on July 10, 2025.

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What the agency says

The Drug Enforcement Administration proposes placing three fentanyl-related substances, as identified in this proposed rule, in schedule I of the Controlled Substances Act. These three substances fall within the definition of fentanyl-related substances set forth in the February 6, 2018 temporary scheduling order. Through the Temporary Reauthorization and Study of Emergency Scheduling of Fentanyl Analogues Act, which became law on February 6, 2020, Congress extended the temporary control of fentanyl-related substances until May 6, 2021. This temporary order was subsequently extended multiple times, most recently on March 15, 2025, which extended the order until September 30, 2025. If finalized, this action would make permanent the existing regulatory controls and administrative, civil, and criminal sanctions applicable to schedule I controlled substances on persons who handle (manufacture, distribute, import, export, engage in research, conduct instructional activities or chemical analysis, or possess), or propose to handle these three specific controlled substances.

Key facts

Document number
2025-10372
Type
Proposed rule
Action
Notice of proposed rulemaking
Agency
Justice Department; Drug Enforcement Administration
Published
June 10, 2025
Comments due
July 10, 2025
Dates
Comments must be submitted electronically or postmarked on or before July 10, 2025.
Docket
Docket No. DEA-1484
Code of Federal Regulations
21 CFR 1308
Topics
Administrative practice and procedure; Drug traffic control; Reporting and recordkeeping requirements
Pages
9

The document on federalregister.gov PDF

Other documents from the Drug Enforcement Administration

Everything from the Drug Enforcement Administration · Rules on administrative practice and procedure · Rules on drug traffic control · Rules on reporting and recordkeeping requirements · Published in June 2025

Read from the Federal Register API, last updated 2026-10-23. The document on federalregister.gov is the official record; dates and dockets can change through later corrections. Free to reuse with credit to SpecStream under CC BY 4.0.