Data / Federal rules / 2025-18103
Schedules of Controlled Substances: Placement of Seven Specific Fentanyl-Related Substances in Schedule I
The Drug Enforcement Administration published this final rule in the Federal Register on September 18, 2025. It took effect on September 18, 2025.
SpecStream is the live web data engine for teams and agents. It reads every rule and proposed rule in the Federal Register each morning, and this page is that reading. Name your industry once and new rules, comment deadlines and effective dates arrive in your sheet, CRM, Slack or agent as they are published.
What the agency says
The Drug Enforcement Administration places seven fentanyl- related substances, as identified in this final rule, including their isomers, esters, ethers, salts and salts of isomers, esters and ethers in schedule I of the Controlled Substances Act. The regulatory controls and administrative, civil, and criminal sanctions applicable to schedule I controlled substances on persons who handle (manufacture, distribute, import, export, engage in research, conduct instructional activities or chemical analysis, or possess), or propose to handle these seven specific controlled substances will continue to apply as a result of this action.
Key facts
- Document number
- 2025-18103
- Type
- Final rule
- Action
- Final rule
- Agency
- Justice Department; Drug Enforcement Administration
- Published
- September 18, 2025
- Takes effect
- September 18, 2025
- Dates
- Effective September 18, 2025.
- Docket
- Docket No. DEA-1457
- Code of Federal Regulations
- 21 CFR 1308
- Topics
- Administrative practice and procedure; Drug traffic control; Reporting and recordkeeping requirements
- Pages
- 6
Other documents from the Drug Enforcement Administration
Everything from the Drug Enforcement Administration · Rules on administrative practice and procedure · Rules on drug traffic control · Rules on reporting and recordkeeping requirements · Published in September 2025
Read from the Federal Register API, last updated 2026-10-23. The document on federalregister.gov is the official record; dates and dockets can change through later corrections. Free to reuse with credit to SpecStream under CC BY 4.0.