Data / New clinical trials / Rectal Neoplasms

Rectal Neoplasms trials: 261 new since Nov 2024

Name: New Rectal Neoplasms clinical trials
Creator: SpecStream
License: https://creativecommons.org/licenses/by/4.0/

The full list. New Rectal Neoplasms clinical trials: 261 rows for $13.05, first posted on ClinicalTrials.gov from November 12, 2024 to November 9, 2026. The list gains about 9 rows a month. The new rows come each week by email, $19 a month.

Pay by card with no account. Prices exclude VAT. CSV and Excel files with the columns this page does not show (sponsor class, condition groups (MeSH), interventions, start date, enrollment type, location countries and 5 more), which open on your screen as soon as the payment clears and come by email. The weekly rows run until you cancel, from the link in each delivery. The rows on this page are a sample.

For agents and scripts: this list is ordered at https://specstream.ai/data/clinical-trials/condition/rectal-neoplasms, and every list with its row count and price is at https://specstream.ai/data/lists.json.

Updated November 6, 2026. Source: ClinicalTrials.gov API v2 (U.S. National Library of Medicine).

261 clinical studies in Rectal Neoplasms were first posted on ClinicalTrials.gov from November 12, 2024 to November 6, 2026; 18 have an industry sponsor and 208 are recruiting or about to. The newest, NCT07923682, was posted on November 6, 2026: Outcomes of Knife-Assisted Full-Thickness Resection for Rectal Lesions: A Multicenter Study (University Hospital, Ghent).

The request: Every new Rectal Neoplasms clinical trial on ClinicalTrials.gov, with the sponsor, phase, sites and the listed contact. $10 of credit on sign-up, no card.

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SpecStream is the live web data engine for teams and agents. It reads every new study on ClinicalTrials.gov each morning, and this page is that reading. Ask for the conditions, phases or countries you follow and each new trial arrives in your sheet, CRM, Slack or agent with the sponsor, the sites and the listed contact.

261New trials
18Industry sponsored
208Recruiting or not yet
November 6, 2026Latest posted

Newest trials

The newest 100 of 261, each linked to its record. The full list holds every one with the sponsor class, interventions, start date and the central contact as the record prints it.

First posted	NCT ID	Title	Sponsor	Phase	Status	Conditions	Enrollment	Countries	Source
November 6, 2026	NCT07923682	Outcomes of Knife-Assisted Full-Thickness Resection for Rectal Lesions: A Multicenter Study	University Hospital, Ghent	Observational	Recruiting	Colorectal Cancer	150	Belgium	clinicaltrials.gov
November 6, 2026	NCT07920770	Pre- and On-treatment Multi-omics Profiling of Locally Advanced Rectal Cancer	Fujian Medical University Union Hospital	Observational	Recruiting	Rectal Neoplasms	100	China	clinicaltrials.gov
November 4, 2026	NCT07916532	Indocyanine Green Lymphatic Mapping in Minimally Invasive Sigmoid and Rectal Cancer Surgery	Jagiellonian University	Not applicable	Completed	Rectal Cancer, Sigmoid Colon Cancer	29	Poland	clinicaltrials.gov
October 29, 2026	NCT07903883	Dose-Escalated Short-Course Proton Therapy for Locally Advanced Rectal Cancer	University of Aarhus	Not applicable	Not yet recruiting	Locally Advanced Rectal Cancer, Rectal Adenocarcinoma	30	Denmark	clinicaltrials.gov
October 28, 2026	NCT07900620	T1 Colorectal Cancer After Local Excision: Decision Between Surgery and Active Surveillance (T1LDA Trial)	Tampere University Hospital	Not applicable	Not yet recruiting	Colorectal Cancer	500	Finland	clinicaltrials.gov
October 28, 2026	NCT07900061	Modified Short-Course Radiotherapy Combined With Tislelizumab and CAPOX for pMMR/MSS Rectal Cancer	Sir Run Run Shaw Hospital	Phase 3	Not yet recruiting	Rectal Cancer	210		clinicaltrials.gov
October 23, 2026	NCT07892404	Purse-String Versus Linear Closure After Ileostomy Reversal	Dnipro Regional Clinical Oncology Dispensary	Not applicable	Completed	Diverting Ileostomy, Rectal Cancer	23	Ukraine	clinicaltrials.gov
October 22, 2026	NCT07888309	SCRT + Fruquintinib + Tislelizumab + CAPOX Versus SCRT + Tislelizumab + CAPOX as Neoadjuvant Therapy for Locally Advanced Low Rectal Cancer	Ruijin Hospital	Phase 2	Recruiting	Rectal Neoplasms, Rectal Cancer, Adenocarcinoma	50	China	clinicaltrials.gov
October 13, 2026	NCT07871227	Follow-up After Oncological Resection by Endoscopic Colorectal ESD (Endoscopic Submucosal Dissection)	University Hospital, Bordeaux	Observational	Not yet recruiting	Colorectal Neoplasms	1,200	France	clinicaltrials.gov
October 7, 2026	NCT07862673	Efficacy of a Novel High Intensive Percutaneous Tibial Nerve Stimulation on Faecal Incontinence in Patients With Low Anterior Resection...	Region Skane	Not applicable	Not yet recruiting	Faecal Incontinence With Faecal Urgency, Rectal Cancer, Radiotherapy Side Effects, Low Anterior Resection Syndrome...	60	Sweden	clinicaltrials.gov
September 29, 2026	NCT07847229	A Prospective, Biomarker-Stratified Phase 2 Study: β-Hydroxybutyrate as a Predictive Biomarker for Short-Course Radiotherapy Followed by...	Tao Zhang	Phase 2	Not yet recruiting	Rectal Cancer, Radiotherapy, Immunotherapy, Chemotherapy	144	China	clinicaltrials.gov
September 29, 2026	NCT07846046	Endoscopic (EID) Versus Surgical (TAMIS) Local Excision for Early Stage Rectal Cancer	Amsterdam UMC, location VUmc	Not applicable	Not yet recruiting	Rectal Cancer Stage I	246	Netherlands	clinicaltrials.gov
September 22, 2026	NCT07833319	Local Methylene Blue Injection for Prevention of Anastomotic Leakage and Permanent Stoma After Low Anterior Resection for Rectal Cancer	Peking University Cancer Hospital & Institute	Phase 2	Recruiting	Rectal Cancers	26	China	clinicaltrials.gov
September 16, 2026	NCT07821775	Robotic vs Laparoscopic and Open Surgery for Abdominopelvic Cancers	Asan Medical Center	Observational	Completed	Pancreatic Neoplasms, Stomach Neoplasms, Rectal Neoplasms, Uterine Cervical Neoplasms, Endometrial Neoplasms, Kidney...	32,949	South Korea	clinicaltrials.gov
September 14, 2026	NCT07817888	mFOLFOXIRI Plus Bevacizumab for Organ Preservation in Locally Advanced Rectal Cancer	Sixth Affiliated Hospital, Sun Yat-sen University	Phase 2	Not yet recruiting	Phase 2 Study	119		clinicaltrials.gov
September 9, 2026	NCT07811128	Leveraging Digital Health Solutions to Collect Patient-Reported Outcomes in Rectal Cancer	University of California, San Francisco	Observational	Not yet recruiting	Rectal Cancer, Non Metastatic Rectal Cancer	150	United States	clinicaltrials.gov
September 9, 2026	NCT07810114	Total Neoadjuvant mFOLFOX6 Plus Suvemcitug and Enlonstobart With Selective Omission of Pelvic Radiotherapy for High-Risk Mid-Rectal Locally...	Fudan University	Phase 2	Not yet recruiting	Rectal Cancer	52	China	clinicaltrials.gov
September 4, 2026	NCT07805369	A Phase 1 Study of DEM301 in Participants With Metastatic Colorectal Cancer	DEM BioPharma, Inc.	Phase 1	Recruiting	Metastatic Colorectal Cancer, Colon Cancer, Rectal Cancer	60	Australia	clinicaltrials.gov
September 3, 2026	NCT07802197	Neoadjuvant Radiotherapy vs Upfront Surgery in Locally Advanced Proximal Rectal Cancer	Istanbul University	Not applicable	Recruiting	Rectal Adenocarcinoma	100	Turkey (Türkiye)	clinicaltrials.gov
September 2, 2026	NCT07799740	Examination of Rectal Blood Supply During Rectal Cancer Surgery Using Laser Speckle Contrast Imaging	University of Aarhus	Not applicable	Not yet recruiting	Rectal Cancer, Total Mesorectal Excision, Laser Speckle Contrast Imaging, Indocyanine Green (ICG), Optical Imaging	100	Denmark	clinicaltrials.gov
August 26, 2026	NCT07786493	HDR Endorectal Brachytherapy With 3D-Printed Guidance and Local Shielding for Rectal Cancer Organ Preservation	Tianjin Medical University Cancer Institute and Hospital	Not applicable	Recruiting	Rectal Cancer, Adenocarcinoma	50	China	clinicaltrials.gov
August 24, 2026	NCT07781774	Improving Colorectal Cancer Screening Uptake Through Education and Stool-Based Testing Outreach	Washington University School of Medicine	Not applicable	Not yet recruiting	Colorectal Cancer (CRC) Screening, CRC Screening, Rectal Cancer, Colon Cancer, Colorectal Cancer	200	United States	clinicaltrials.gov
August 21, 2026	NCT07780305	ABCSG R07 Rectal Cancer Registry	Austrian Breast & Colorectal Cancer Study Group	Observational	Recruiting	Rectal Cancer, Adenocarcinoma of Rectum	600	Austria	clinicaltrials.gov
August 21, 2026	NCT07779694	16-Hour Fasting Plus Serplulimab and CAPEOX as Neoadjuvant Therapy in pMMR/MSS Advanced Mid-to-Low Rectal Cancer	Zhejiang University	Phase 2	Not yet recruiting	pMMR/MSS, Locally Advanced Rectal Carcinoma, Fasting, Intermittent	51		clinicaltrials.gov
August 19, 2026	NCT07774754	Radiotherapy Combined With Capeox Chemotherapy, Sintilimab and Suvemcitug in Locally Advanced pMMR Rectal Cancer:a Prospective Clinical...	Sun Yat-sen University	Phase 2	Not yet recruiting	Rectal Cancer	18	China	clinicaltrials.gov
August 14, 2026	NCT07765667	NCT + PD1 + Ketogenic Diet and/or Vitamin C for LARC	Sixth Affiliated Hospital, Sun Yat-sen University	Phase 2	Not yet recruiting	Rectal Adenocarcinoma, High-Risk Cancer, MSS	100	China	clinicaltrials.gov
August 13, 2026	NCT07764120	Quality of Life of Patients After Rectal Cancer Resection .	University Hospital, Grenoble	Observational	Not yet recruiting	Rectal Cancer	22		clinicaltrials.gov
August 12, 2026	NCT07761169	Randomized Controlled Trial of the SurgDiff Model for Predicting Surgical Difficulty to Help Choose Approach in Mid-Low Rectal Cancer	Peking Union Medical College Hospital	Not applicable	Not yet recruiting	Rectal Cancer	68		clinicaltrials.gov
August 10, 2026	NCT07755124	Dietary Arginine Deprivation Combined With Chemoradiotherapy for Neoadjuvant Treatment of Rectal Cancer: A Randomized Controlled Trial	West China Hospital	Phase 1/2	Not yet recruiting	Rectal Neoplasms	140		clinicaltrials.gov
August 3, 2026	NCT07740720	A Study of the Duration of Dostarlimab in Untreated Mismatch Repair Deficient (dMMR)/ Microsatellite Instability-high (MSI-H) Locally...	GlaxoSmithKline	Phase 3	Not yet recruiting	Neoplasms, Rectal	90		clinicaltrials.gov
July 30, 2026	NCT07736131	Learning Curve of SILS in CRC	Ruijin Hospital	Observational	Completed	Rectal Cancer, Colon Cancer, Single Port Laparoscopy	280		clinicaltrials.gov
July 30, 2026	NCT07735624	RECTIFY-1: Neoadjuvant Botensilimab + Balstilimab in MSS/pMMR Early Rectal Cancer	Dana-Farber Cancer Institute	Phase 2	Recruiting	Early Rectal Cancer, Stage I Rectal Cancer, Microsatellite Stable Rectal Carcinoma	16	United States	clinicaltrials.gov
July 29, 2026	NCT07732894	Aerobic Exercise and Guided Imagery in Low Anterior Resection Syndrome	Biruni University	Not applicable	Recruiting	Rectal Cancer, Fecal Incontinence and Constipation, Aerobic Exercise, Guided Imagery Exercise, Pelvic Floor Physical...	50	Turkey (Türkiye)	clinicaltrials.gov
July 28, 2026	NCT07730541	Hyperpolarized 13C-MRI and Radiomics in Rectal Cancer	Chang Gung Memorial Hospital	Observational	Recruiting	Neoadjuvant Chemoradiotherapy	30	Taiwan	clinicaltrials.gov
July 27, 2026	NCT07726966	Betacyanin for Early Diagnosis and Recovery of Anastomotic Leakage After Rectal Cancer Surgery: A Single-Center, Prospective, Controlled...	Southwest Hospital, China	Not applicable	Not yet recruiting	Rectum Cancer, Anastomotic Leak	120	China	clinicaltrials.gov
July 24, 2026	NCT07725692	Predictors of Rescue Surgery, Mortality, and Permanent Stoma After Anastomotic Leak Following Colorectal Cancer Resection	Alexandria University	Observational	Completed	Anastomotic Leak, Colorectal Cancer, Colon Cancer, Postoperative Complication, Intestinal Stoma	3,200	Egypt	clinicaltrials.gov
July 22, 2026	NCT07720505	COLOFLOW: Laser Speckle Contrast Imaging Versus Near-infrared Fluorescence Imaging With Indocyanine Green	Leiden University Medical Center	Observational	Not yet recruiting	Leakage, Anastomotic, Colon Cancer, Colon Anastomosis, Colon and Rectal Cancer, Colon Benign Tumor, Colon and Rectal...	30		clinicaltrials.gov
July 17, 2026	NCT07711509	Autologous Fecal Microbiota Transplantation for Anal Function Recovery After Ileostomy Reversal in Rectal Cancer	Peking University People's Hospital	Not applicable	Active not recruiting	Rectal Cancer, Low Anterior Resection Syndrome, Fecal Incontinence, Diversion Colitis, Ileostomy, Gut Microbiota...	35	China	clinicaltrials.gov
July 10, 2026	NCT07696689	Evaluating the Optimal Timing of Trans-Anal Irrigation for Low Anterior Resection Syndrome Post-rectal Cancer Surgery	Simona Ascanelli	Not applicable	Not yet recruiting	Low Anterior Resection Syndrome (LARS)	250		clinicaltrials.gov
July 10, 2026	NCT07695519	SCARLET - Italian proSpeCtionAl obseRvationaL multicEntre Study on Treatment for recTal pT1 Cancer	Fondazione Policlinico Universitario Agostino Gemelli IRCCS	Observational	Not yet recruiting	Rectal Cancer, Rectal Adenocarcinoma, Rectal Cancer Patients, Rectal Cancer, Radiotherapy	196	Italy	clinicaltrials.gov
July 9, 2026	NCT07691489	A Study of Trastuzumab Deruxtecan (T-DXd) and Cetuximab in People With Colorectal Cancer	Memorial Sloan Kettering Cancer Center	Phase 2	Not yet recruiting	Colorectal Cancer, Adenocarcinoma of the Colon, Adenocarcinoma of the Rectum	27	United States	clinicaltrials.gov
July 7, 2026	NCT07688135	Quicksilver II Pilot Study	Mount Sinai Hospital, Canada	Not applicable	Not yet recruiting	Stage II Rectal Cancer, Stage III Rectal Cancer	18		clinicaltrials.gov
July 7, 2026	NCT07687875	Oncolytic Virotherapy to Enhance PReoperative IMmunotherapy Efficacy in Patients With Proficient Mismatch Repair (pMMR) Rectal Cancer	Henry Smith	Phase 1	Recruiting	Rectal Cancer Patients	20	Denmark	clinicaltrials.gov
June 25, 2026	NCT07669298	Active Surveillance vs Adjuvant Chemoradiotherapy for Locally Resected Intermediate-Risk T1 Rectal Cancer	Medical University of Gdansk	Not applicable	Recruiting	Rectal Cancer	480	France, Poland	clinicaltrials.gov
June 25, 2026	NCT07669220	A Multicenter, Randomized Controlled Phase II Study of Short-Course Radiotherapy Followed by Sequential PD-1 Inhibitor and FOLFOX...	Sixth Affiliated Hospital, Sun Yat-sen University	Phase 2	Recruiting	Rectal Adenocarcinoma, High-risk Locally Advanced, Short-course Radiotherapy (SCRT), Immunotherapy, FOLFOX	76	China	clinicaltrials.gov
June 16, 2026	NCT07651553	Transanal Total Mesorectal Excision vs Robotic Total Mesorectal Excision	Sun Yat-sen University	Not applicable	Recruiting	Rectal Cancer Patients, Robotic Assisted Intervention	216	China	clinicaltrials.gov
June 15, 2026	NCT07646639	Different-Dose SCRT Plus CAPOX, PD-1 Blockade and IL-2 in LARC	The First Affiliated Hospital with Nanjing Medical University	Phase 2	Recruiting	Rectal Cancer, Radiotherapy	122	China	clinicaltrials.gov
June 8, 2026	NCT07632196	Efficacy and Safety of Transcutaneous Posterior Tibial Nerve Stimulation on Fecal Continence in Patients Undergoing Surgery for Rectal...	Althaia Xarxa Assistencial Universitària de Manresa	Not applicable	Recruiting	Low Anterior Resection Syndrome (LARS), Rectal Neoplasm Malignant, Quality of Life (QOL), Fecal Incontinence (FI)...	84	Spain	clinicaltrials.gov
June 5, 2026	NCT07629960	A First-in-Human Trial of BLU-924 (SAR449336) in Advanced Solid Tumors Harboring KRAS Mutations	Blueprint Medicines Corporation	Phase 1/2	Recruiting	Advanced Solid Tumor, Non-Small Cell Lung Cancer, Colorectal Neoplasms, Pancreatic Ductal Adenocarcinoma	265	Spain, United States	clinicaltrials.gov
June 3, 2026	NCT07622771	Neoadjuvant Radiotherapy Combined With NALIRIFOX and Adebrelimab in pMMR/MSS Locally Advanced Rectal Cancer: A Prospective, Randomized...	Sun Yat-sen University	Phase 2	Recruiting	Rectal Cancers	84	China	clinicaltrials.gov
June 2, 2026	NCT07622017	KORTUC (KRC-01) Plus Radiotherapy for Organ Preservation in Rectal Cancer	Gustave Roussy, Cancer Campus, Grand Paris	Phase 2	Not yet recruiting	Rectal Cancer	24	France	clinicaltrials.gov
June 2, 2026	NCT07619768	Self Regulation Hypnotic Intervention for Pain and Anxiety During Rectal Brachytherapy	Sir Mortimer B. Davis - Jewish General Hospital	Not applicable	Completed	Rectal Cancer	52	Canada	clinicaltrials.gov
June 1, 2026	NCT07616297	Higher Radiation Dose to the Tumor May Help Avoid Surgery in Rectal Cancer Patients	Claudia Schuurhuizen	Not applicable	Recruiting	Rectal Cancer, Radiation Oncology	25	Netherlands	clinicaltrials.gov
May 28, 2026	NCT07610798	A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Antitumor Activity of INV-8989 in Patients With Advanced...	Shenzhen Ionova Life Sciences Co., Ltd.	Phase 1/2	Recruiting	Advance Solid Tumors, Colon and Rectal Cancer, Non - Small Cell Lung Cancer NSCLC, Pancreatic Adenocarcinoma Advanced...	178	China	clinicaltrials.gov
May 26, 2026	NCT07605611	Somatostatin Plus Clear Liquid Diet Versus Diverting Stoma in Patients With Rectal Cancer Undergoing Ultra-Low Anterior Resection	Tongji Hospital	Not applicable	Recruiting	Rectal Cancer, Anastomotic Leakage	72	China	clinicaltrials.gov
May 19, 2026	NCT07596732	Statewide Unified Network for Remote Intervention of Strength and Exercise	AdventHealth Translational Research Institute	Not applicable	Not yet recruiting	Gastric Cancer (Diagnosis), Esophagus Cancer, Pancreas Cancer, Colon Cancer, Rectal Cancer, Lung Cancer	120		clinicaltrials.gov
May 19, 2026	NCT07595874	Neoadjuvant Botensilimab and Balstilimab for the Treatment of Advanced Resectable Colorectal Cancer NEST3	City of Hope Medical Center	Phase 2	Recruiting	Advanced Colon Adenocarcinoma, Advanced Colorectal Adenocarcinoma, Advanced Rectal Adenocarcinoma, Stage IIB Colon...	100	United States	clinicaltrials.gov
May 19, 2026	NCT07595107	Concordance Between Large Language Model and Multidisciplinary Team Recommendations in Rectal Cancer	Shandong Cancer Hospital and Institute	Observational	Recruiting	Rectal Cancer	180	China	clinicaltrials.gov
May 19, 2026	NCT07594925	Short-Course Radiotherapy Followed by Immunotherapy Combined With Chemotherapy for Microsatellite Stable Locally Advanced Rectal Cancer: A...	Tianjin Medical University Cancer Institute and Hospital	Phase 2	Recruiting	Rectal Cancer	130	China	clinicaltrials.gov
May 12, 2026	NCT07580339	Combining DCSZ11 With Radiation and Chemotherapy as Neoadjuvant Treatment for pMMR Locally Advanced Rectal Cancer	Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins	Phase 2	Not yet recruiting	Rectal Cancer	30	United States	clinicaltrials.gov
May 5, 2026	NCT07566559	Rectal Cancer Neoadjuvant Therapy-Real World Study	Beijing Friendship Hospital	Observational	Recruiting	Rectal Cancer	869	China	clinicaltrials.gov
May 4, 2026	NCT07563907	Total Neoadjuvant Therapy With Additional Consolidation Chemotherapy Followed by Local Excision Versus Total Neoadjuvant Therapy Followed...	Seoul National University Hospital	Not applicable	Not yet recruiting	Organ Preservation, Rectal Cancer Stage I, Total Neoadjuvant Treatment, Consolidation Therapy, Capecitabine	292	South Korea	clinicaltrials.gov
May 1, 2026	NCT07561060	Low Rectal Cancer Treated With Total Neoadjuvant Therapy Plus Concurrent Tislelizumab Immunotherapy	Fudan University	Phase 1/2	Recruiting	Rectal Cancer	50	China	clinicaltrials.gov
April 27, 2026	NCT07552207	Comparison of [68Ga]Ga-CTR-FAPI and 18F-FDG PET/MRI for Lymph Node Staging in Rectal Cancer	Peking University Cancer Hospital & Institute	Not applicable	Not yet recruiting	Rectal Cancer, Lymph Node Metastases, PET / MR	30		clinicaltrials.gov
April 24, 2026	NCT07549399	SCRT + Chemo Targeted Immuno-neoadjuvant Therapy for High-risk pMMR/MSS RC	Sixth Affiliated Hospital, Sun Yat-sen University	Phase 3	Recruiting	Rectal Adenocarcinoma, High-Risk Cancer, MSS	204	China	clinicaltrials.gov
April 23, 2026	NCT07548736	Improvement Effect of Dexamethasone Enema for Acute Radiation-induced Rectal Injury	Sixth Affiliated Hospital, Sun Yat-sen University	Phase 2	Not yet recruiting	Acute Radiation Enteritis	40	China	clinicaltrials.gov
April 22, 2026	NCT07543848	A Prospective, Multicenter, Single-Arm Phase II Exploratory Study of Serplulimab Combined With Oncolytic Virus H101, Short-Course...	Chongqing University Cancer Hospital	Phase 2	Not yet recruiting	Rectal Neoplasms, Rectal Adenocarcinoma	20	China	clinicaltrials.gov
April 17, 2026	NCT07537998	Antegrade Intestinal Fluid Reinfusion for Prevention of Low Anterior Resection Syndrome After Low Anterior Resection: a Single-Center...	Pei-Rong Ding	Phase 2/3	Recruiting	Low Anterior Resection Syndrome, Rectal Cancer	160	China	clinicaltrials.gov
April 17, 2026	NCT07536321	Diagnostic Accuracy and Prognostic Value of 18F FDG PET-CT in the Follow up of Patients With Colorectal Carcinoma.	Assiut University	Observational	Not yet recruiting	Rectal Cancer (Stage III)	46		clinicaltrials.gov
April 14, 2026	NCT07528209	Neoadjuvant CAPOX With or Without Pucotenlimab Plus Selective Radiotherapy for Locally Advanced Rectal Cancer	Sun Yat-sen University	Phase 3	Recruiting	Rectal Cancer, pMMR (Microsatellite Stable Rectal Cancer)	556	China	clinicaltrials.gov
April 14, 2026	NCT07527520	Neoadjuvant Moderately Hypofractionated Radiotherapy Combined With Chemotherapy and Immunotherapy for High-risk pMMR/MSS Locally Advanced...	Fudan University	Phase 2	Not yet recruiting	Rectal Cancer, Moderately Hypofractionated Radiotherapy, Serplulimab, pMMR/MSS	165	China	clinicaltrials.gov
April 13, 2026	NCT07522294	Optimization and Standardization of Single-Port Robotic Transanal Minimally Invasive Surgery for Rectal Tumor Excision	Jeng-Fu You	Not applicable	Active not recruiting	Rectal Neoplasms, Rectal Cancer Patients, Rectal Benign Lesions	20	Taiwan	clinicaltrials.gov
April 7, 2026	NCT07516210	Adaptive Radiotherapy for Safe Hypofractionation	Centre hospitalier de l'Université de Montréal (CHUM)	Phase 2	Not yet recruiting	Cancer, Endometrial Cancer, Prostate Cancer, Cervical Cancer, Rectal Cancers	264	Canada	clinicaltrials.gov
April 6, 2026	NCT07512232	Intraoperative Rectal Lavage to Prevent Local Recurrence After Laparoscopic Mid-to-Low Rectal Cancer Resection: A Multicenter Randomized...	Sun Yat-sen University	Not applicable	Recruiting	Middle and Low Rectal Cancer, Rectal Cancer Surgery	1,598	China	clinicaltrials.gov
April 3, 2026	NCT07509632	Predicting Pathological Complete Response in Rectal Cancer Using Machine Learning	Peking University People's Hospital	Observational	Active not recruiting	Rectal Cancers, Pathological Complete Response, Neoadjuvant Chemoradiotherapy, Machine Learning	320	China	clinicaltrials.gov
April 3, 2026	NCT07509424	Neoadjuvant Short-course Radiotherapy Followed by a Combination of Disitamab Vedotin, Sintilimab, and Capecitabine in Locally Advanced...	Union Hospital, Tongji Medical College, Huazhong University of Science and Technology	Phase 2	Not yet recruiting	Rectal Cancer	29		clinicaltrials.gov
April 1, 2026	NCT07505472	Efficacy and Safety Comparison of Short-course Radiotherapy Followed by CapeOX Chemotherapy Plus Toripalimab With or Without Concurrent...	The First Hospital of Jilin University	Phase 2/3	Recruiting	Rectal Cancer	212	China	clinicaltrials.gov
March 30, 2026	NCT07501845	Registry Maastro Applicator	Maastricht Radiation Oncology	Observational	Recruiting	Rectal Cancer	999	Netherlands	clinicaltrials.gov
March 30, 2026	NCT07499921	Clinical and BIOgical Analyses of RECtal Tumors	Centre Leon Berard	Not applicable	Not yet recruiting	Rectal Cancer	300	France	clinicaltrials.gov
March 27, 2026	NCT07494201	MIMICC Study in Patients With Colorectal Cancer	Fondazione del Piemonte per l'Oncologia	Not applicable	Recruiting	Colorectal Cancer, Colon Cancer, Rectal Cancers	2,500	Italy	clinicaltrials.gov
March 20, 2026	NCT07486180	The Application of a Novel Endoluminal Robotic System for Colorectal Endoscopic Submucosal Dissection	Chinese University of Hong Kong	Not applicable	Not yet recruiting	Early Rectal Neoplasms	10	China	clinicaltrials.gov
March 19, 2026	NCT07483060	Next Generation STAR-TREC (NG-ST) - Organ Preservation in Early Rectal Cancer	Vastra Gotaland Region	Phase 4	Not yet recruiting	Rectal Cancer	90		clinicaltrials.gov
March 16, 2026	NCT07474103	SCRT-NALIRIXELOX+Sintilimab as TNT for High-Risk LARC	Union Hospital, Tongji Medical College, Huazhong University of Science and Technology	Not applicable	Recruiting	Rectal Cancer, Adenocarcinoma	49	China	clinicaltrials.gov
March 12, 2026	NCT07467434	FOLFIRINOX Induction Chemotherapy for Synchronous Liver Metastases	Assistance Publique - Hôpitaux de Paris	Observational	Recruiting	Rectal Cancer, Synchronous Liver Metastases, Antineoplastic Combined Chemotherapy Protocols, Surgical Therapy	550	France	clinicaltrials.gov
March 11, 2026	NCT07463261	REsults of LOw Anterior Resections With or Without Preventive Stoma in Nonemergency Department	ANO Scientific and Practical Club for the Development of Modern Medical Technologies	Not applicable	Recruiting	TME, Rectal Cancer Surgery, Low Rectal Cancer, Middle Rectal Cancer, Local Advanced Rectal Cancer	442	Russia	clinicaltrials.gov
March 10, 2026	NCT07460596	Concentrated Complex Plant Dietary Elements for Chemotherapy-Induced Diarrhea	Tianjin Medical University Cancer Institute and Hospital	Phase 2	Completed	Gastric Adenocarcinoma or Gastroesophageal Junction Adenocarcinoma or Esophageal Carcinoma, Colon and Rectal Cancer	30	China	clinicaltrials.gov
March 9, 2026	NCT07458529	Neoadjuvant Chemoradiotherapy Plus Tislelizumab With or Without Probio-M9 in pMMR/MSS Locally Advanced Rectal Cancer	Seventh Medical Center of PLA General Hospital	Phase 2	Recruiting	Rectal Cancer, Adenocarcinoma, Neoadjuvant Therapy, Immunotherapy, Probio-M9, Tislelizumab, Randomized	50	China	clinicaltrials.gov
March 9, 2026	NCT07458347	A Phase 1 Dose Escalation and Dose Expansion Trial of KST-6051 in Participants With Advanced Solid Tumors With Kirsten Rat Sarcoma Viral...	Kestrel Therapeutics, Inc.	Phase 1	Recruiting	KRAS-mutant Non-small Cell Lung Cancer (NSCLC), KRAS-mutant Pancreatic Ductal Adenocarcinoma (PDAC), KRAS-mutant...	545	United States	clinicaltrials.gov
March 4, 2026	NCT07448662	Local Treatment Strategies for Brain Metastases of Colorectal Cancer	Blokhin's Russian Cancer Research Center	Observational	Active not recruiting	Colorectal Cancer, Brain Metastases, Adult	700	Belarus, Russia	clinicaltrials.gov
February 25, 2026	NCT07433673	Gemcitabine, Cisplatin, Nab-paclitaxel (GAP) and Cemiplimab for Locally Advanced Biliary Tract Cancer (BTC)	Columbia University	Phase 2	Recruiting	Colon and Rectal Cancer	20	United States	clinicaltrials.gov
February 25, 2026	NCT07432542	Pelvic Floor Peritoneal Closure to Prevent Postoperative Ileus in Mid-Low Rectal Cancer Surgery	Sun Yat-sen University	Not applicable	Active not recruiting	Rectal Cancer Surgery, Middle and Low Rectal Cancer, Intestinal Obstruction, Ileus	516	China	clinicaltrials.gov
February 24, 2026	NCT07429110	ColoSeal™ ICD System Anastomotic Protection Pivotal Study	Averto Medical, Inc.	Not applicable	Active not recruiting	Rectal Cancer Surgery	250	New Zealand, United States	clinicaltrials.gov
February 23, 2026	NCT07428239	Pilot Study of Individualized Comprehensive Rehabilitation in Patients With Colorectal Cancer	Institute of Oncology Ljubljana	Not applicable	Completed	Colon Cancer, Rectal Cancer	150	Slovenia	clinicaltrials.gov
February 23, 2026	NCT07427901	Quality Of Life In Colorectal Cancer Survivors	Institute of Oncology Ljubljana	Not applicable	Recruiting	Colorectal Cancer, Colon Cancer, Rectal Cancer	368	Slovenia	clinicaltrials.gov
February 19, 2026	NCT07419516	MRA Diameter as a Predictor for LLN Metastasis in Rectal Cancer.	First Affiliated Hospital of Fujian Medical University	Observational	Completed	Rectal Neoplasms	690	China	clinicaltrials.gov
February 19, 2026	NCT07419490	Utero-ovarian Transposition in Patients With Pelvic Malignancies Undergoing Whole Pelvic Radiotherapy	University of South Florida	Not applicable	Recruiting	Colorectal (Colon or Rectal) Cancer, Pelvic Malignancies, Oncofertility	26	United States	clinicaltrials.gov
February 13, 2026	NCT07410767	Advanced Endoscopic Resections for Rectal Neoplasms	Jagiellonian University	Observational	Not yet recruiting	Rectal Cancer, Rectal Adenocarcinoma, Rectal Adenoma, Rectal Neuroendocrine Neoplasm, Recurrent Rectal Adenocarcinoma	300	Poland	clinicaltrials.gov
February 12, 2026	NCT07407647	Vaginal DHEA to Improve Vaginal Health After Radiation for Women With Gynecologic, Anal or Rectal Cancer	Ohio State University Comprehensive Cancer Center	Phase 2	Recruiting	Anal Carcinoma, Cervical Carcinoma, Malignant Female Reproductive System Neoplasm, Rectal Carcinoma, Vaginal Carcinoma...	25	United States	clinicaltrials.gov
February 12, 2026	NCT07407465	Upfront Trastuzumab-Deruxtecan Plus Capecitabine and Bevacizumab for Patients With HER-2 Positive Metastatic Colorectal Cancer.	Gruppo Oncologico del Nord-Ovest	Phase 2	Recruiting	Colorectal Cancer, Colorectal Adenocarcinoma, Rectal Adenocarcinoma, Rectal Cancer, Adenocarcinoma, Rectal Cancer...	42	France, Germany, Italy, Spain	clinicaltrials.gov
February 12, 2026	NCT07405476	Zanidatamab Before Surgery for the Treatment of HER2 Positive Colon and Rectal Cancer in Patients Planned for Curative Intent Treatment	Emory University	Phase 2	Recruiting	Colon Carcinoma, Colorectal Carcinoma, Rectal Carcinoma, Stage I Colon Cancer AJCC v8, Stage I Colorectal Cancer AJCC...	38	United States	clinicaltrials.gov

Sponsors posting most

Sponsor	New trials	Latest
Sixth Affiliated Hospital, Sun Yat-sen University	13	September 14, 2026
Sun Yat-sen University	11	August 19, 2026
Fudan University	5	September 9, 2026
Sir Run Run Shaw Hospital	4	October 28, 2026
Ruijin Hospital	4	October 22, 2026
Peking University Cancer Hospital & Institute	4	September 22, 2026
Chang Gung Memorial Hospital	4	July 28, 2026
Yanhong Deng	4	March 28, 2025
Tao Zhang	3	September 29, 2026
Tianjin Medical University Cancer Institute and Hospital	3	August 26, 2026
West China Hospital	3	August 10, 2026
GlaxoSmithKline	3	August 3, 2026
City of Hope Medical Center	3	May 19, 2026
Beijing Friendship Hospital	3	May 5, 2026
The First Hospital of Jilin University	3	April 1, 2026
Cancer Institute and Hospital, Chinese Academy of Medical Sciences	3	December 29, 2025
Alliance for Clinical Trials in Oncology	3	December 16, 2025
Jagiellonian University	2	November 4, 2026
University of Aarhus	2	October 29, 2026
Amsterdam UMC, location VUmc	2	September 29, 2026

By phase

Phase	New trials	Latest
Not applicable	83	November 4, 2026
Phase 2	72	October 22, 2026
Observational	67	November 6, 2026
Phase 3	14	October 28, 2026
Phase 1/2	8	August 10, 2026
Phase 1	7	September 4, 2026
Phase 2/3	6	April 17, 2026
Phase 4	3	March 19, 2026
Early phase 1	1	April 17, 2025

By country

Country	New trials	Latest
China	94	November 6, 2026
United States	35	September 9, 2026
France	15	October 13, 2026
Turkey (Türkiye)	10	September 3, 2026
Taiwan	10	July 28, 2026
Italy	10	July 10, 2026
Spain	9	June 8, 2026
Netherlands	8	September 29, 2026
South Korea	7	September 16, 2026
Germany	7	February 12, 2026
Belgium	5	November 6, 2026
Poland	5	November 4, 2026
Egypt	5	July 24, 2026
Canada	5	June 2, 2026
United Kingdom	5	January 15, 2026
Denmark	4	October 29, 2026
Sweden	4	October 7, 2026
Australia	3	September 4, 2026
Puerto Rico	3	December 16, 2025
Japan	3	October 9, 2025
Brazil	3	May 30, 2025
Finland	2	October 28, 2026
Ukraine	2	October 23, 2026
Russia	2	March 11, 2026
Slovenia	2	February 23, 2026

Where the register publishes

U.S. government data; ClinicalTrials.gov terms of use. Studies are as their sponsors registered them on ClinicalTrials.gov, read through its API. Condition groups are the MeSH terms ClinicalTrials.gov assigns to each study's conditions; a study with several is in several groups. Sponsor class is the register's class of the lead sponsor. The central contact is in the full list only as the record prints it. Free to reuse with credit to SpecStream under CC BY 4.0. Spot a wrong value? Write to [email protected] with the link to this page.