Data / New clinical trials / Esophageal Neoplasms

Esophageal Neoplasms trials: 221 new since Nov 2024

Name: New Esophageal Neoplasms clinical trials
Creator: SpecStream
License: https://creativecommons.org/licenses/by/4.0/

The full list. New Esophageal Neoplasms clinical trials: 221 rows for $11.05, first posted on ClinicalTrials.gov from November 12, 2024 to November 9, 2026. The list gains about 9 rows a month. The new rows come each week by email, $19 a month.

Pay by card with no account. Prices exclude VAT. CSV and Excel files with the columns this page does not show (central contact, contact phone, contact email, sponsor class, condition groups (MeSH), interventions and 5 more), which open on your screen as soon as the payment clears and come by email. The weekly rows run until you cancel, from the link in each delivery. The rows on this page are a sample.

For agents and scripts: this list is ordered at https://specstream.ai/data/clinical-trials/condition/esophageal-neoplasms, and every list with its row count and price is at https://specstream.ai/data/lists.json.

Updated October 29, 2026. Source: ClinicalTrials.gov API v2 (U.S. National Library of Medicine).

221 clinical studies in Esophageal Neoplasms were first posted on ClinicalTrials.gov from November 12, 2024 to October 29, 2026; 40 have an industry sponsor and 183 are recruiting or about to. The newest, NCT07904260, was posted on October 29, 2026: Effect of High-flow Nasal Cannula Oxygenation on the Incidence of Hypoxemia During Painless Gastrointestinal... (Diansan Su).

The request: Every new Esophageal Neoplasms clinical trial on ClinicalTrials.gov, with the sponsor, phase, sites and the listed contact. $10 of credit on sign-up, no card.

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SpecStream is the live web data engine for teams and agents. It reads every new study on ClinicalTrials.gov each morning, and this page is that reading. Ask for the conditions, phases or countries you follow and each new trial arrives in your sheet, CRM, Slack or agent with the sponsor, the sites and the listed contact.

221New trials
40Industry sponsored
183Recruiting or not yet
October 29, 2026Latest posted

Newest trials

The newest 100 of 221, each linked to its record. The full list holds every one with the sponsor class, interventions, start date and the central contact as the record prints it.

First posted	NCT ID	Title	Sponsor	Phase	Status	Conditions	Enrollment	Countries	Source
October 29, 2026	NCT07904260	Effect of High-flow Nasal Cannula Oxygenation on the Incidence of Hypoxemia During Painless Gastrointestinal Endoscopy in Patients at High...	Diansan Su	Not applicable	Not yet recruiting	Hypoxemia, Gastric Cancer (Diagnosis), Esophageal Cancer, High-altitude Illness, Obstructive Sleep Apnea (OSA)	430	China	clinicaltrials.gov
October 29, 2026	NCT07903415	A Study to Learn About the Study Medicine Called PF-08098488 in People With Advanced Solid Tumors.	Pfizer	Phase 1	Recruiting	Pancreatic Ductal Adenocarcinoma, Esophageal Cancer, Carcinoma, Non-Small-Cell Lung (NSCLC), Gastric Carcinoma...	280	United States	clinicaltrials.gov
October 29, 2026	NCT07902544	Station-Specific Lymph Node Metastasis After Neoadjuvant Chemoimmunotherapy for Middle Thoracic Esophageal Squamous Cell Carcinoma	Daping Hospital and the Research Institute of Surgery of the Third Military Medical University	Observational	Completed	Esophageal Squamous Cell Carcinoma, Esophageal Neoplasms, Metastasis	717		clinicaltrials.gov
October 22, 2026	NCT07890038	The Clinical Application Value of CAIX-Targeted PET Hypoxia Imaging in Malignant Tumors	Union Hospital, Tongji Medical College, Huazhong University of Science and Technology	Observational	Active not recruiting	Nasopharyngeal Cancers, Lung Cancer (NSCLC), Esophageal Cancer, Glioma	50	China	clinicaltrials.gov
October 22, 2026	NCT07888140	Modular Robot-Assisted Versus Conventional Minimally Invasive Esophagectomy for Esophageal Cancer	Ruijin Hospital	Phase 3	Recruiting	Esophageal Cancer	160	China	clinicaltrials.gov
October 7, 2026	NCT07863141	A Phase II Study of Anlotinib + PD-1 Inhibitor vs. PD-1 Inhibitor Maintenance After First-Line Chemoimmunotherapy in Advanced ESCC...	Sun Yat-sen University	Phase 2	Recruiting	Esophageal Cancer (EC)	112	China	clinicaltrials.gov
September 22, 2026	NCT07834268	Feasibility of Multi-cancer Early Detection Test in Screening Population (NQMD-CS)	Fifth Affiliated Hospital of Guangzhou Medical University	Not applicable	Active not recruiting	Colorectal Cancer, Grastic Cancer, Esophageal Cancer, Lung Cancer, Liver Cancer	1,250	China	clinicaltrials.gov
September 18, 2026	NCT07828314	Patient Priorities in the Management of Early Oesophageal Cancer: A Discrete Choice Study	Portsmouth Hospitals NHS Trust	Observational	Completed	Oesophageal Cancer	118	United Kingdom	clinicaltrials.gov
September 16, 2026	NCT07822399	A Study of MGC030 in Participants With Advanced Solid Tumors	MacroGenics	Phase 1	Recruiting	Urothelial Cancer, GastroEsophageal Cancer, Colorectal Cancer, Esophageal Cancer, Gastric Cancer (GC), Pancreatic Cancer	314	United States	clinicaltrials.gov
September 14, 2026	NCT07818018	A Study of 2141-V11 in People With Esophageal, Gastric, or Gastroesophageal Junction Adenocarcinoma	Memorial Sloan Kettering Cancer Center	Phase 1/2	Recruiting	Esophageal Cancer, Advanced Esophageal Cancer, Gastric Cancer, Advanced Gastric Cancer, Gastroesophageal Junction...	30	United States	clinicaltrials.gov
September 10, 2026	NCT07814248	A Phase 1, First-in-Human (FIH), Open-Label, Dose-Escalation and Dose Expansion Study of the Peptide Drug Conjugate (PDC), TS-104, as a...	TwoStep Therapeutics, Inc.	Phase 1	Recruiting	NSCLC (Non-small Cell Lung Cancer), HNSCC, Endometrial, Ovarian Cancer, Esophageal Cancer, Head & Neck Cancer, Gastric...	74	United States	clinicaltrials.gov
September 10, 2026	NCT07812805	SKL35501 With SKL35502 Imaging in Adults With NTSR1 Positive Advanced Solid Tumors	SK Life Science, Inc.	Phase 1	Recruiting	Selected Advanced Solid Tumors, Colorectal Cancer (CRC), Pancreatic Ductal Adenocarcinoma (PDAC), Biliary Tract Cancer...	100	South Korea, United States	clinicaltrials.gov
September 8, 2026	NCT07807345	Phase 1 Study of STRO-006 in Adults With Refractory Solid Tumors That Are Recurrent or Metastatic	Sutro Biopharma, Inc.	Phase 1	Recruiting	Head & Neck Squamous Cell Carcinoma, Non-Small Cell Lung Cancer, Esophageal Cancer, Gastric Cancer, Colorectal Cancer...	285	United States	clinicaltrials.gov
September 8, 2026	NCT07806500	Phase Ib Study of Oral R01 Monotherapy in Advanced Solid Tumors	Beijing Anjianxi Bio-Medical Technology Co., Ltd.	Phase 1	Not yet recruiting	Squamous Cell Lung Cancer, Gastric Cancer, Esophageal Cancer	18	China	clinicaltrials.gov
August 31, 2026	NCT07795749	Ph II Intraperitoneal Paclitaxel + System Therapy in GI Ca w/Peritoneal Carcinomatosis (STOPGAP-B)	University of California, Irvine	Phase 2	Recruiting	Esophageal Carcinoma, Gastric Cancer (Diagnosis), Colorectal Adenocarcinoma, Appendiceal Adenocarcinoma, Small Bowel...	55	United States	clinicaltrials.gov
August 28, 2026	NCT07791979	High-Flow Nasal Cannula Oxygenation During Sedated Gastrointestinal Endoscopy in Patients With Chronic Obstructive Pulmonary Disease	Zhejiang University	Not applicable	Not yet recruiting	Hypoxemia, Gastric Cancer (Diagnosis), Chronic Obstructive Pulmonary Disease (COPD), Esophageal Cancer	90	China	clinicaltrials.gov
August 26, 2026	NCT07788001	A Non-inferiority Study of Indocyanine Green-guided Sentinel Lymph Node Mapping Versus Conventional Lymph Node Dissection in Esophageal...	Fujian Medical University Union Hospital	Phase 3	Not yet recruiting	Esophageal Cancer, Sentinel Lymph Node, Lymphadenectomy, Indocyanine Green (ICG), Disease Free Survival	200	China	clinicaltrials.gov
August 24, 2026	NCT07781852	Evaluation of the Distribution of 64Cu/68Ga Labeled CM500 in Healthy Volunteers and Patients With Cancer	Lumina Pharmaceuticals Inc	Early phase 1	Not yet recruiting	Bladder Cancer, Glioma, Glioblastoma (GBM), Breast Cancer, Colorectal Cancer, Esophageal Cancer, Gastric Cancer (GC)...	40	United States	clinicaltrials.gov
August 24, 2026	NCT07780968	Zanidatamab Outcomes and Lived Experiences in Advanced HER2+ GEA	Jazz Pharmaceuticals	Observational	Not yet recruiting	Esophageal Cancer, GastroEsophageal Cancer, Gastroesophageal-junction Cancer, HER2-positive Gastric Cancer, Stomach...	300	United States	clinicaltrials.gov
August 21, 2026	NCT07780721	Study of Adebrelimab Combined With Thymalfasin and Chemotherapy for Neoadjuvant Treatment of Esophageal Cancer	The Affiliated Hospital of Putian University	Phase 2	Not yet recruiting	Esophageal Cancer	31	China	clinicaltrials.gov
August 21, 2026	NCT07778056	Neoadjuvant Chemoradiotherapy Versus Neoadjuvant Immunochemotherapy for Resectable Esophageal Cancer: A Target Trial Emulation Study	Henan Cancer Hospital	Observational	Not yet recruiting	Esophageal Squamous Cell Carcinoma (ESCC)	400		clinicaltrials.gov
August 20, 2026	NCT07775859	NOMAD-GI: Molecular-guided Non-operative Management and Organ Preservation Strategy After Precision Therapy in Gastrointestinal Cancers	Peking University Cancer Hospital & Institute	Observational	Not yet recruiting	Gastrointestinal Cancer, Gastric Cancer, Gastroesophageal Junction Cancer, Esophageal Cancer, Colorectal Cancer	200		clinicaltrials.gov
August 18, 2026	NCT07770672	An Exploratory Clinical Study of Accurate Efficacy Assessment of Neoadjuvant Immunotherapy in Locally Advanced Esophageal Squamous Cell...	Tan Lijie	Phase 2	Not yet recruiting	Esophageal Cancer, ESCC	92	China	clinicaltrials.gov
August 18, 2026	NCT07770100	Concurrent Immunotherapy and Systemic Therapy With Stereotactic Body Radiation Therapy (SBRT) for Stage IV Cancers (COINSSS IV)	Mark Bernard	Phase 2	Recruiting	Head and Neck Cancer, Non-Small Cell Lung Cancer, Cervical Cancer, Esophageal Cancer, Gastric Cancer (GC)	35	United States	clinicaltrials.gov
August 11, 2026	NCT07757022	AI-Driven Digital Twin and Drug Simulation for Esophageal Cancer	Henan Cancer Hospital	Observational	Not yet recruiting	Esophageal Cancer	400		clinicaltrials.gov
August 7, 2026	NCT07752875	A Study of LG00313112 in Participants With Advanced Solid Malignancies Harboring a TP53 Y220C Mutation	LG Chem	Phase 1/2	Not yet recruiting	Ovarian Cancer, Small Cell Lung Cancer, Non Small Cell Lung Cancer, Colorectal Cancer, Esophageal Cancer, Breast...	250		clinicaltrials.gov
August 6, 2026	NCT07749586	A Study to Evaluate ARV-6723 Alone and With Pembrolizumab in Participants With Advanced Solid Tumors	Arvinas Inc.	Phase 1/2	Recruiting	Advanced Solid Tumor	499	United States	clinicaltrials.gov
August 4, 2026	NCT07745322	Spatial MSC Index for Predicting Anti-PD-1 Efficacy in Esophageal Cancer	Peking University Cancer Hospital & Institute	Observational	Active not recruiting	Esophageal Squamous Cell Carcinoma, Esophageal Neoplasms	270	China	clinicaltrials.gov
July 29, 2026	NCT07733830	Comparing ICI Followed By CCRT And CCRT Followed By Immunotherapy In Unresectable LA-ESCC	Tianjin Medical University Cancer Institute and Hospital	Phase 2	Recruiting	Esophageal Cancer	120	China	clinicaltrials.gov
July 20, 2026	NCT07714538	Breath Research Narrow Validation for Gastrointestinal Cancer Detection	Imperial College London	Observational	Recruiting	Oesophageal Squamous Cell Carcinoma, Oesophageal Adenocarcinoma, Gastric Adenocarcinoma, Pancreatic Ductal...	1,000	United Kingdom	clinicaltrials.gov
July 14, 2026	NCT07702253	O-GlcNAcylation Induced HMGB1 Signalling	Chinese University of Hong Kong	Observational	Active not recruiting	Esophageal Squamous Cell Carcinoma (ESCC)	120	Hong Kong	clinicaltrials.gov
July 14, 2026	NCT07700420	Perioperative FLOT(D) With Personalized Ultrafractionated Stereotactic Adaptive Radiotherapy (PULSAR) in Esophageal Cancer	University of Texas Southwestern Medical Center	Phase 1	Recruiting	Gastro-esophageal Junction (GEJ) Cancer, Esophagus Cancer	15	United States	clinicaltrials.gov
July 9, 2026	NCT07692204	A Dose Optimization/Expansion Study of SAR445877 in Adult Chinese Participants With Advanced Gastric or Gastroesophageal Junction Cancer	Sanofi	Phase 2	Recruiting	Gastric Cancer, Oesophageal Carcinoma	30	China	clinicaltrials.gov
July 9, 2026	NCT07691944	Effect of VExUS Score on Postoperative Pulmonary Complications in Elderly Patients	First Affiliated Hospital of Chongqing Medical University	Observational	Not yet recruiting	Esophageal Cancer (EsC), Postoperative Pulmonary Complications (PPCs)	126		clinicaltrials.gov
July 6, 2026	NCT07685938	Pharmacologic Therapies to Mitigate Radiation- Associated Heart Disease	UNC Lineberger Comprehensive Cancer Center	Phase 2	Recruiting	Chest Wall Tumor, Breast Cancer, Lung Cancer, Esophageal Cancer, Mediastinal Cancers, Spine Metastases, Spinal Tumor...	60	United States	clinicaltrials.gov
June 26, 2026	NCT07671625	Comprehensive Perioperative Program Based on Prehabilitation, Nutritional Intervention and Psychological Support for Patients With Locally...	Masaryk Memorial Cancer Institute	Not applicable	Recruiting	Locally Advanced Esophageal Cancer, Gastroesophageal Junction Cancer, Gastric Cancer	60	Czechia	clinicaltrials.gov
June 18, 2026	NCT07658313	Digitally Supported Prehabilitation Before Major Visceral Cancer Surgery	Ludwig Boltzmann Institute for Digital Health and Prevention	Not applicable	Not yet recruiting	Gastrointestinal Neoplasms, Pancreatic Neoplasms, Liver Neoplasm, Oesophageal Cancer, Gastrointestinal Cancer...	30	Austria	clinicaltrials.gov
June 11, 2026	NCT07642492	REcovery After Cancer Application	Karolinska Institutet	Not applicable	Not yet recruiting	Oesophageal Cancer, Gastric Cancer (Diagnosis)	250	Sweden	clinicaltrials.gov
June 11, 2026	NCT07642401	Large-scale Models of Esophageal Cancer and Related Research	The First Affiliated Hospital of Henan University of Science and Technology	Observational	Enrolling by invitation	Esophageal Cancer	12,000	China	clinicaltrials.gov
June 10, 2026	NCT07638410	Prehabilitation in High-risk Oncologic Surgery	Fox Chase Cancer Center	Not applicable	Recruiting	Pancreatic Cancer, Colo-rectal Cancer, Gastric Cancer, Esophageal Cancer, Bladder Cancer, Ovarian Cancer, Abdominal...	180	United States	clinicaltrials.gov
June 5, 2026	NCT07629921	Multimodal Al for Precision Diagnosis of Esophageal Cancer	Shanghai Zhongshan Hospital	Observational	Terminated	Esophageal Cancer	264	China	clinicaltrials.gov
June 4, 2026	NCT07625930	RESTAGE (REpurposing STAtins to Improve Outcomes in GastroEsophageal Cancer) Trial	McGill University Health Centre/Research Institute of the McGill University Health Centre	Phase 2	Not yet recruiting	Gastroesophageal Adenocarcinoma	184	Canada	clinicaltrials.gov
June 1, 2026	NCT07617246	The Efficacy and Safety of Fosrolapitant and Palonosetron Hydrochloride for Injection in Preventing Nausea and Vomiting Caused by...	Second Affiliated Hospital, Zhejiang University, School of Medicine	Phase 2	Recruiting	Esophagus Cancer, Lung Cancer	120	China	clinicaltrials.gov
May 22, 2026	NCT07605312	AI-Based Risk Prediction Model for Upper Digestive Tract Cancer	National Taiwan University Hospital	Observational	Not yet recruiting	Gastric Cancer (GC), Premalignant Lesion, Gastric Intestinal Metaplasia, Atrophic Gastritis, Dysplasia Stomach...	10,000		clinicaltrials.gov
May 22, 2026	NCT07603375	Upfront Chemotherapy With Radiation Therapy (CRT) Followed by Chemotherapy in Localized Esophageal Adenocarcinoma	Duke University	Phase 2	Recruiting	Esophageal Adenocarcinoma	60	United States	clinicaltrials.gov
May 19, 2026	NCT07596732	Statewide Unified Network for Remote Intervention of Strength and Exercise	AdventHealth Translational Research Institute	Not applicable	Not yet recruiting	Gastric Cancer (Diagnosis), Esophagus Cancer, Pancreas Cancer, Colon Cancer, Rectal Cancer, Lung Cancer	120		clinicaltrials.gov
May 19, 2026	NCT07596654	The Impact of Surgical Treatment on Survival in Localized Small Cell Esophageal Cancer	yi shen	Observational	Recruiting	Esophageal Carcinoma, Limited-Stage Small Cell Esophageal Carcinoma	4	China	clinicaltrials.gov
May 19, 2026	NCT07594626	BMS-986504 in Combination With Pemetrexed for the Treatment of Metastatic Solid Tumors With MTAP Deletion	Northwestern University	Phase 1/2	Recruiting	Metastatic Biliary Tract Carcinoma, Metastatic Colon Carcinoma, Metastatic Esophageal Carcinoma, Metastatic Malignant...	72	United States	clinicaltrials.gov
May 13, 2026	NCT07584577	Evaluation of the Administration of Artificial Nutrition by Feeding Jejunostomy During Neoadjuvant Treatment on Postoperative Morbidity in...	University Hospital, Bordeaux	Observational	Recruiting	Esophageal Cancer, Surgery Indication, Malnourished, Neoadjuvant Treatment	670	France	clinicaltrials.gov
May 13, 2026	NCT07583316	A Phase 1 First-in-Human Study of CRPA1A2, a MAGE-A1/HLA-A*02:01 Bispecific T-Cell Engager, in Patients With Solid Tumors	Corregene Biotechnology Co., Ltd	Phase 1	Not yet recruiting	Lung Cancer (Locally Advanced or Metastatic), Esophagus Cancer, Head and Neck Cancer, Hepatocellular Carcinoma (HCC)	192	China	clinicaltrials.gov
May 11, 2026	NCT07578571	A Phase 1 Study of IM-1617 in Participants With Advanced Cancer	Immunome, Inc.	Phase 1	Recruiting	Colorectal Cancer, Non-Small Cell Lung Cancer, Breast Cancer, Esophageal Cancer, Stomach Cancer, Cancer	200	United States	clinicaltrials.gov
May 7, 2026	NCT07573397	A Prospective Study of Tumor-specific Tpex in Negative Lymph Nodes for Predicting Pathological Complete Response to Neoadjuvant PD 1...	Fudan University	Observational	Not yet recruiting	Esophageal Cancer	88		clinicaltrials.gov
May 4, 2026	NCT07565857	Signatera-Guided De-escalation of Adjuvant Therapy in Resectable Stage II-IVa Gastric/Gastric-Esophageal Cancer	Natera, Inc.	Not applicable	Not yet recruiting	Gastric-Esophageal Cancer	1,000		clinicaltrials.gov
May 1, 2026	NCT07561840	Exercise Training After Upper Gastrointestinal Cancer Surgery	Kansai Medical University	Not applicable	Recruiting	Esophageal Cancer, Gastric Cancer (Diagnosis), Upper Gastrointestinal Cancer	171	Japan	clinicaltrials.gov
April 24, 2026	NCT07549269	Comparison of Nab-Paclitaxel Versus Paclitaxel in Neoadjuvant Immunochemotherapy Therapy for Esophageal Squamous Cell Carcinoma: A...	Sichuan University	Observational	Completed	Esophageal Cancer	387	China	clinicaltrials.gov
April 16, 2026	NCT07533357	Tpex Subsets in Negative Tumor Draining Lymph Nodes for Predicting the Efficacy of PD 1 Inhibitors in Advanced or Recurrent Esophageal...	Fudan University	Observational	Not yet recruiting	Esophageal Cancer	158		clinicaltrials.gov
April 15, 2026	NCT07530549	A Phase II Single-arm Clinical Study in the Treatment of Locally Advanced Esophageal Cancer After Failed Neoadjuvant Chemoimmunotherapy	Cancer Institute and Hospital, Chinese Academy of Medical Sciences	Phase 2	Not yet recruiting	Local Advanced Esophageal Cancer	40		clinicaltrials.gov
April 15, 2026	NCT07530094	Short-Course Definitive Chemoradiotherapy Combined With Adjuvant or Concurrent Plus Adjuvant Camrelizumab for Locally Advanced Unresectable...	Ning Jiang, M.D./Ph.D.	Phase 2	Recruiting	Locally Advanced Unresectable Esophageal Squamous Cell Carcinoma	98	China	clinicaltrials.gov
April 9, 2026	NCT07519655	Phase 1 Study of PF-08046033 in Advanced Solid Tumors	Pfizer	Phase 1	Recruiting	Non-Small-Cell Lung, Esophageal Cancer, Cutaneous Melanoma	250	France, Netherlands, Puerto Rico, South Korea, Spain, United States	clinicaltrials.gov
April 9, 2026	NCT07519486	Intensive Nutritional Support in Conversion Therapy for Locally Advanced Unresectable ESCC	Sichuan University	Phase 2	Recruiting	Esophageal Squamous Cell Carcinoma, Locally Advanced Unresectable Esophageal Squamous Cell Carcinoma	118	China	clinicaltrials.gov
April 8, 2026	NCT07518680	A Clinical Study on the Effect of Massaging Tian Tu Acupoint on Coughing After Esophageal Surgery	Shanghai Zhongshan Hospital	Not applicable	Not yet recruiting	Esophageal Neoplasms	30	China	clinicaltrials.gov
March 19, 2026	NCT07482566	Proximal Versus Total Gastrectomy for Locally Advanced Siewert Type II-III Gastroesophageal Junction Cancer	Nurettin Şahin	Not applicable	Recruiting	Gastroesophageal Junction Cancer, Stomach Neoplasms, Esophageal Neoplasms	120	Turkey (Türkiye)	clinicaltrials.gov
March 11, 2026	NCT07464470	Comparison of Molecular-Genetic Concordance of the Primary Tumor and Brain Metastases of Gastroesophageal Cancers	Blokhin's Russian Cancer Research Center	Observational	Recruiting	Gastric Cancer, Esophageal Cancer, Brain Metastases	30	Russia	clinicaltrials.gov
March 10, 2026	NCT07460596	Concentrated Complex Plant Dietary Elements for Chemotherapy-Induced Diarrhea	Tianjin Medical University Cancer Institute and Hospital	Phase 2	Completed	Gastric Adenocarcinoma or Gastroesophageal Junction Adenocarcinoma or Esophageal Carcinoma, Colon and Rectal Cancer	30	China	clinicaltrials.gov
March 6, 2026	NCT07455019	A Study of Bemosubaiabimab Combined With Anlotinib and Radiotherapy and Chemotherapy for the Treatment of Oligometastatic Esophageal Cancer	The First Affiliated Hospital with Nanjing Medical University	Phase 2	Recruiting	Esophageal Cancer	28	China	clinicaltrials.gov
March 4, 2026	NCT07448493	Local Treatment Strategies for Brain Metastases of Gastric and Esophageal Cancer	Blokhin's Russian Cancer Research Center	Observational	Active not recruiting	Gastric Cancer, Esophageal Cancer, Brain Metastases	230	Belarus, Russia	clinicaltrials.gov
February 27, 2026	NCT07440212	Clinical Study on Noninvasive Evaluation of Ivonescimab Antibody Distribution and Expression in Esophageal Cancer Patients by 89Zr-AK112...	Daping Hospital and the Research Institute of Surgery of the Third Military Medical University	Observational	Not yet recruiting	Esophagus Cancer	50	China	clinicaltrials.gov
February 27, 2026	NCT07435454	Exploratory Clinical Trial of Oral Paclitaxel Plus Radiotherapy in Patients With Locally Advanced Unresectable Esophageal Squamous Cell...	Jiangsu Cancer Institute & Hospital	Phase 2	Recruiting	Locally Advanced Unresectable Esophageal Squamous Cell Carcinoma	22	China	clinicaltrials.gov
February 27, 2026	NCT07434739	PAravertebral CaTheter Versus Epidural Analgesia in Totally Minimally Invasive Esophagectomies	University Hospital, Lille	Not applicable	Recruiting	Esophageal Cancer, Esophagectomy, Multimodal Analgesia, Minimally Invasive Surgery	506	France	clinicaltrials.gov
February 24, 2026	NCT07431281	Sonesitatug Vedotin in Combination With Capecitabine With or Without Rilvegostomig in Participants With Advanced or Metastatic Gastric...	AstraZeneca	Phase 3	Recruiting	Gastric Cancer, Gastroesophageal Junction Adenocarcinoma, Esophageal Cancer	2,130	Australia, Austria, Belgium, Brazil, Canada, China, France, Germany, Hungary...	clinicaltrials.gov
February 18, 2026	NCT07416825	Inter-Observer Delineation Differences in Esophageal Cancer GTV on MR, CT, and PET/CT Protokol šečerov Ermenc 28dec19	Institute of Oncology Ljubljana	Not applicable	Completed	Esophageal Cancer, Esophageal Carcinoma	23	Slovenia	clinicaltrials.gov
February 13, 2026	NCT07410676	EBNK-001 Allogeneic NK Cells With Low-Dose IL-15 ± Pembrolizumab in Advanced Solid Tumors	Essen Biotech	Phase 1/2	Recruiting	Cancer, Sarcoma, Leukaemia, Breast Cancer (Locally Advanced or Metastatic), Lung Cancer (Diagnosis), Colorectal Cancer...	83	China	clinicaltrials.gov
February 12, 2026	NCT07406815	The Value of Near-Infrared Fluorescence Imaging in the Protection of the Recurrent Laryngeal Nerve During Minimally Invasive Esophagectomy	Fujian Medical University Union Hospital	Phase 3	Not yet recruiting	Esophageal Cancer, Recurrent Laryngeal Nerve, ICG (Indocyanine Green), Lymph Node Dissection	144	China	clinicaltrials.gov
February 6, 2026	NCT07392775	ALDH2 Genetic Testing in East Asian Community	Northwestern University	Not applicable	Not yet recruiting	Healthy Adult, Flushing	100	United States	clinicaltrials.gov
February 5, 2026	NCT07390838	A Study of SH009 Injection in Patients With Advanced Solid Tumors.	Nanjing Sanhome Pharmaceutical, Co., Ltd.	Phase 1	Recruiting	Liver Cancer (Locally Advanced or Metastatic), Lung Cancer (NSCLC), Head and Neck Cancer Squamous Cell Carcinoma...	150	China	clinicaltrials.gov
February 3, 2026	NCT07382635	Clinical Trial Protocol for Evaluating the Efficacy and Safety of Thoracoabdominal Endoscopic Surgery System in Remote Laparoscopic Surgery...	Cornerstone Robotics	Observational	Not yet recruiting	Colorectal Cancer, Esophageal Cancer, Hepatectomy, Radical Hysterectomy	98		clinicaltrials.gov
January 29, 2026	NCT07376876	Indocyanine Green-guided Omental Shield Anastomosis for Cervical Esophagogastric Anastomosis in Minimally Invasive McKeown Esophagectomy	Daping Hospital and the Research Institute of Surgery of the Third Military Medical University	Phase 2	Not yet recruiting	Esophageal Squamous Cell Carcinoma (ESCC), Esophageal Cancer	73	China	clinicaltrials.gov
January 29, 2026	NCT07375420	Will a Pre-therapy Exercise Intervention Improve the Outcomes of Patients With Advanced Oesophageal Cancer?	University of Surrey	Not applicable	Recruiting	Oesophageal Adenocarcinoma, T Cells, Tumor Microenvironment, Exercise	50	United Kingdom	clinicaltrials.gov
January 27, 2026	NCT07371247	Based on ctDNA-MRD Guided Adjuvant Treatment Escalation After Definitive Chemoradiotherapy for Unresectable Locally Advanced Esophageal...	The First Affiliated Hospital with Nanjing Medical University	Early phase 1	Enrolling by invitation	Esophageal Cancer, MRD, ctDNA	65	China	clinicaltrials.gov
January 26, 2026	NCT07367516	Clinical Trial Evaluating TQB6411 Injection in Participant s With Esophageal Cancer	Chia Tai Tianqing Pharmaceutical Group Co., Ltd.	Phase 1/2	Recruiting	Esophageal Cancer	105	China	clinicaltrials.gov
January 26, 2026	NCT07365124	MRinRT: Swansea University and SWWCC Collaboration Study.	Swansea Bay University Health Board	Observational	Not yet recruiting	Carcinoma, Glioblastoma, Radiotherapy, MRI, MRI-guided Adaptive Radiotherapy, MRI Scanner Configuration, MRI Image...	165	United Kingdom	clinicaltrials.gov
January 21, 2026	NCT07354295	Integrating Multimodal AI to Predict Treatment Response and Refine Risk Stratification in Esophageal Cancer （Radiogenomics-Esophagus）	Shu Peng	Observational	Recruiting	Esophageal Cancer	1,500	China	clinicaltrials.gov
January 14, 2026	NCT07341737	SL-28 for Advanced Solid Tumours	Second Life Therapeutics	Phase 1/2	Recruiting	Head & Neck Cancer, Pancreas Carcinoma, Pancreas Cancer, Metastatic, Lung Adenocarcinoma, Lung Cancer (NSCLC), Lung...	60	Australia	clinicaltrials.gov
January 12, 2026	NCT07332221	Application of Toripalimab as Adjuvant Therapy After Esophageal Cancer Surgery: A Multicenter Clinical Trial	Henan Cancer Hospital	Phase 3	Not yet recruiting	Esophageal Cancer	435		clinicaltrials.gov
January 9, 2026	NCT07330583	Stereotactic Body Radiation Therapy (SBRT) and Immunotherapy for Oligometastatic Esophageal Cancer	AHS Cancer Control Alberta	Phase 2	Not yet recruiting	Esophageal Cancer	22		clinicaltrials.gov
January 7, 2026	NCT07324018	Spirulina Derivative for Radiation Esophagitis	West China Hospital	Phase 2	Not yet recruiting	Radiation-induced Esophagitis	70	China	clinicaltrials.gov
January 7, 2026	NCT07322627	ALDH2 Single Nucleotide Polymorphisms and Prognosis of Esophageal Cancer Patients	National Taiwan University Hospital	Observational	Recruiting	Esophageal Cancer	700	Taiwan	clinicaltrials.gov
December 31, 2025	NCT07312526	Shanghai Clinical Cohort - Esophageal Cancer	Shanghai Chest Hospital	Observational	Completed	Esophageal Cancer, Esophagectomy	2,116	China	clinicaltrials.gov
December 30, 2025	NCT07309991	Postoperative Hypoxemia Increases the Risk of Anastomotic Leak After Radical Esophagectomy	Sun Yat-sen University	Observational	Recruiting	Esophageal Carcinoma, Esophageal Adenocarcinoma, Esophagectomy, PaO2, Esophageal Anastomotic Leakeage	2,500	China	clinicaltrials.gov
December 29, 2025	NCT07307560	High-Flow Nasal Cannula for Preventing Hypoxia During Sedated Endoscopy in High-Risk Obstructive Sleep Apnea Patients	Zhejiang University	Not applicable	Recruiting	Hypoxia, Esophageal Cancer, Gastric Cancer (Diagnosis), Obstructive Sleep Apnea (OSA)	600	China	clinicaltrials.gov
December 29, 2025	NCT07306663	Sintilimab Combined With Chemotherapy Induction Therapy Followed by CCRT vs. CCRT for Esophageal Cancer: A Randomized Controlled Phase Ⅲ...	Jiangsu Cancer Institute & Hospital	Phase 3	Active not recruiting	Esophageal Cancer	242	China	clinicaltrials.gov
December 24, 2025	NCT07303231	The Value of Indocyanine Green-guided Near-infrared Fluorescence Technology in Tracing Sentinel Lymph Nodes During Esophagectomy	Fujian Medical University Union Hospital	Phase 3	Not yet recruiting	Esophageal Cancer, Sentinel Lymph Node, Lymphadenectomy, Indocyanine Green	144	China	clinicaltrials.gov
December 24, 2025	NCT07301814	Clinical Application of PET Imaging Targeting CLDN18.2 in Malignant Tumors	Union Hospital, Tongji Medical College, Huazhong University of Science and Technology	Observational	Recruiting	Gastric Cancer, Pancreatic Cancer, Cholangiocarcinoma Cancer, Esophageal Cancer	56	China	clinicaltrials.gov
December 16, 2025	NCT07283991	QL1706 Plus Chemotherapy for Borderline Resectable Esophageal Cancer	Ruijin Hospital	Phase 2	Not yet recruiting	Esophageal Cancer	24		clinicaltrials.gov
December 16, 2025	NCT07283939	Studying the PAGODA Algorithm for Chemotherapy Dose Changes to Prevent Unplanned Treatment Delays	Alliance for Clinical Trials in Oncology	Not applicable	Recruiting	Ampulla of Vater Carcinoma, Appendix Carcinoma, Carcinoma of Unknown Primary With Gastrointestinal Profile, Colon...	420	Guam, Puerto Rico, United States	clinicaltrials.gov
December 9, 2025	NCT07272382	Omega-3 Fatty Acids With PD-1 Inhibitors in Advanced Esophageal Cancer	Fudan University	Not applicable	Recruiting	Esophageal Neoplasms	142	China	clinicaltrials.gov
December 3, 2025	NCT07260734	AUGMENTED RESPONSE OF VOLATILE BIOMARKERS IN THE ASSESSMENT OF OESOPHAGOGASTRIC CANCER (AROMA2)	Imperial College London	Observational	Not yet recruiting	OESOPHAGO-GASTRIC CARCINOMA, Oesophageal Adenocarcinoma, Gastric Adenocarcinoma and Gastroesophageal Junction...	6,000		clinicaltrials.gov
November 26, 2025	NCT07251114	AI-assisted Endoscopic Ultrasound Grading of Early Esophageal Cancer Invasion Depth: A Multicenter, Prospective, Randomized Cohort Study	Fujian Provincial Hospital	Not applicable	Recruiting	Esophageal Cancer Stage, Early Esophageal Cancer	200	China	clinicaltrials.gov
November 18, 2025	NCT07233850	A Phase II Clinical Study Evaluating SSGJ-706 in Combination Therapy for Advanced Gastrointestinal Cancers	Shenyang Sunshine Pharmaceutical Co., LTD.	Phase 2	Not yet recruiting	Gastric/Gastroesophageal Junction Adenocarcinoma, Metastatic Colorectal Cancer (CRC), Pancreatic Ductal Adenocarcinoma...	300	China	clinicaltrials.gov
November 12, 2025	NCT07227168	A Study of STRO-004 in Adults With Refractory/Recurrent Metastatic Cancer	Sutro Biopharma, Inc.	Phase 1	Recruiting	Head and Neck Squamous Cell Carcinoma HNSCC, Non-Small Cell Lung Cancer NSCLC, Esophageal Cancer, Gastric Cancer...	200	United States	clinicaltrials.gov

Sponsors posting most

Sponsor	New trials	Latest
Zhejiang University	8	August 28, 2026
Fudan University	8	May 7, 2026
Henan Cancer Hospital	6	August 21, 2026
Tianjin Medical University Cancer Institute and Hospital	6	July 29, 2026
Sichuan University	6	April 24, 2026
Sun Yat-sen University	4	October 7, 2026
Peking University Cancer Hospital & Institute	4	August 20, 2026
Shanghai Zhongshan Hospital	4	June 5, 2026
Pfizer	3	October 29, 2026
Daping Hospital and the Research Institute of Surgery of the Third Military Medical University	3	October 29, 2026
Ruijin Hospital	3	October 22, 2026
Fujian Medical University Union Hospital	3	August 26, 2026
National Taiwan University Hospital	3	May 22, 2026
Cancer Institute and Hospital, Chinese Academy of Medical Sciences	3	April 15, 2026
Anhui Provincial Hospital	3	September 23, 2025
Fujian Cancer Hospital	3	July 1, 2025
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology	2	October 22, 2026
Sutro Biopharma, Inc.	2	September 8, 2026
Jazz Pharmaceuticals	2	August 24, 2026
Imperial College London	2	July 20, 2026

By phase

Phase	New trials	Latest
Observational	65	October 29, 2026
Phase 2	53	October 7, 2026
Not applicable	48	October 29, 2026
Phase 1	26	October 29, 2026
Phase 1/2	13	September 14, 2026
Phase 3	12	October 22, 2026
Early phase 1	2	August 24, 2026
Phase 4	1	August 15, 2025
Phase 2/3	1	January 17, 2025

By country

Country	New trials	Latest
China	104	October 29, 2026
United States	46	October 29, 2026
Netherlands	8	April 9, 2026
Spain	8	April 9, 2026
United Kingdom	7	September 18, 2026
South Korea	7	September 10, 2026
Canada	7	June 4, 2026
France	7	May 13, 2026
Japan	6	May 1, 2026
Australia	5	February 24, 2026
Puerto Rico	4	April 9, 2026
Germany	4	February 24, 2026
Italy	4	February 24, 2026
Taiwan	4	February 24, 2026
Turkey (Türkiye)	3	March 19, 2026
Switzerland	3	June 15, 2025
Austria	2	June 18, 2026
Russia	2	March 11, 2026
Belgium	2	February 24, 2026
Brazil	2	February 24, 2026
Hungary	2	February 24, 2026
Hong Kong	1	July 14, 2026
Czechia	1	June 26, 2026
Sweden	1	June 11, 2026
Belarus	1	March 4, 2026

Where the register publishes

U.S. government data; ClinicalTrials.gov terms of use. Studies are as their sponsors registered them on ClinicalTrials.gov, read through its API. Condition groups are the MeSH terms ClinicalTrials.gov assigns to each study's conditions; a study with several is in several groups. Sponsor class is the register's class of the lead sponsor. The central contact is in the full list only as the record prints it. Free to reuse with credit to SpecStream under CC BY 4.0. Spot a wrong value? Write to [email protected] with the link to this page.