Data / New clinical trials / Depressive Disorder, Major

Depressive Disorder, Major trials: 380 new since Nov 2024

Name: New Depressive Disorder, Major clinical trials
Creator: SpecStream
License: https://creativecommons.org/licenses/by/4.0/

The full list. New Depressive Disorder, Major clinical trials: 380 rows for $19, first posted on ClinicalTrials.gov from November 12, 2024 to November 9, 2026. The list gains about 20 rows a month. The new rows come each week by email, $19 a month.

Pay by card with no account. Prices exclude VAT. CSV and Excel files with the columns this page does not show (central contact, contact phone, contact email, sponsor class, condition groups (MeSH), interventions and 5 more), which open on your screen as soon as the payment clears and come by email. The weekly rows run until you cancel, from the link in each delivery. The rows on this page are a sample.

For agents and scripts: this list is ordered at https://specstream.ai/data/clinical-trials/condition/depressive-disorder-major, and every list with its row count and price is at https://specstream.ai/data/lists.json.

Updated November 9, 2026. Source: ClinicalTrials.gov API v2 (U.S. National Library of Medicine).

380 clinical studies in Depressive Disorder, Major were first posted on ClinicalTrials.gov from November 14, 2024 to November 9, 2026; 76 have an industry sponsor and 283 are recruiting or about to. The newest, NCT07925281, was posted on November 9, 2026: Emotional Reactivity in Severe Alcohol Use Disorder and Major Depressive Disorder Using Eye-tracking... (Université Catholique de Louvain).

The request: Every new Depressive Disorder, Major clinical trial on ClinicalTrials.gov, with the sponsor, phase, sites and the listed contact. $10 of credit on sign-up, no card.

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SpecStream is the live web data engine for teams and agents. It reads every new study on ClinicalTrials.gov each morning, and this page is that reading. Ask for the conditions, phases or countries you follow and each new trial arrives in your sheet, CRM, Slack or agent with the sponsor, the sites and the listed contact.

380New trials
76Industry sponsored
283Recruiting or not yet
November 9, 2026Latest posted

Newest trials

The newest 100 of 380, each linked to its record. The full list holds every one with the sponsor class, interventions, start date and the central contact as the record prints it.

First posted	NCT ID	Title	Sponsor	Phase	Status	Conditions	Enrollment	Countries	Source
November 9, 2026	NCT07925281	Emotional Reactivity in Severe Alcohol Use Disorder and Major Depressive Disorder Using Eye-tracking, Physiological, and Interoceptive...	Université Catholique de Louvain	Observational	Recruiting	Alcohol Use Disorder, Major Depressive Disorder (MDD)	280	Belgium	clinicaltrials.gov
November 9, 2026	NCT07925047	Individualized Temporal Interference Stimulation for Reward Processing in Late-Life Depression	Beijing HuiLongGuan Hospital	Not applicable	Not yet recruiting	Major Depressive Disorder (MDD	70	China	clinicaltrials.gov
November 9, 2026	NCT07924917	Individualized Temporally Interfering Electrical Stimulation in Major Depressive Disorder	Tianjin Medical University General Hospital	Not applicable	Recruiting	Major Depressive Disorder (MDD)	75	China	clinicaltrials.gov
November 9, 2026	NCT07924852	Neuromodulation of Motivation and Reward Oscillations	Florida State University	Not applicable	Recruiting	Cannabis Use Disorder, Major Depression, Anhedonia, Transcranial Alternating Current Stimulation	54	United States	clinicaltrials.gov
November 6, 2026	NCT07921654	Acute Intermittent Hypoxia Therapy for Depression	Capital Medical University	Not applicable	Not yet recruiting	Major Depressive Disorder (MDD)	156		clinicaltrials.gov
November 6, 2026	NCT07921446	Preventive and Personalized Digital Emotion Regulation Skills Intervention to Reduce Depression and Anxiety in Youths With Adverse...	Institute of Mental Health, Singapore	Not applicable	Not yet recruiting	Adverse Childhood Experience, Depression / Major Depressive Disorder, Anxiety Depression, Anxiety	140		clinicaltrials.gov
November 5, 2026	NCT07920302	Affective Cognitive Training in Mood Disorders and High-risk Relatives	Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital	Not applicable	Recruiting	Major Depressive Disorder (MDD), Bipolar Disorder (BD)	100	Denmark	clinicaltrials.gov
November 2, 2026	NCT07910318	Neurostructural and Biochemical Signatures of Tobacco Smoking in Mood Disorders	Assiut University	Observational	Not yet recruiting	Major Depressive Disorder, Bipolar Disorder, Tobacco Use Disorder, Mood Disorders	240		clinicaltrials.gov
November 2, 2026	NCT07908563	Dupilumab in Major Depressive Disorder	Icahn School of Medicine at Mount Sinai	Phase 2	Recruiting	Major Depressive Disorder	34	United States	clinicaltrials.gov
October 30, 2026	NCT07906496	Acceptance and Committment Therapy Combined With Ketamine in Difficult-to-Treat Depression.	University of British Columbia	Not applicable	Not yet recruiting	Major Depressive Disorder (MDD)	50	Canada	clinicaltrials.gov
October 29, 2026	NCT07905378	Validation of Wearable Core Body Temperature-Based Circadian Rhythm Digital Biomarkers	Korea University Anam Hospital	Observational	Not yet recruiting	Mood Disorders, Major Depressive Diorder, Bipolar Disorders, Mental Disorder	200		clinicaltrials.gov
October 28, 2026	NCT07901179	A Study to Evaluate the Safety and Efficacy of ALKS 7290 as an Adjunctive Therapy to Antidepressants in Adult Participants With Major...	Alkermes, Inc.	Phase 2	Recruiting	Major Depressive Disorder (MDD)	180	United States	clinicaltrials.gov
October 26, 2026	NCT07895134	Psilocybin for Depression in Veterans	VA Office of Research and Development	Phase 2	Not yet recruiting	Major Depression	150	United States	clinicaltrials.gov
October 23, 2026	NCT07891806	REM Sleep Disruption and Its Potential Uses in Depression Management	WAKEZ HEALTH TECH ECOSYSTEM SRL	Not applicable	Completed	Depression / Major Depressive Disorder, Depressed Mood	208	Romania	clinicaltrials.gov
October 23, 2026	NCT07891624	Neural Mechanisms of Real-world Emotions and Internalizing	University of Miami	Not applicable	Recruiting	Major Depression, Generalized Anxiety, Emotions	144	United States	clinicaltrials.gov
October 22, 2026	NCT07889908	Testing a Non-Deceptive Placebo Intervention for Subclinical Depressive Symptoms	Miami University	Not applicable	Not yet recruiting	Depression - Major Depressive Disorder, Psychological Distress, Depression / Major Depressive Disorder	330	United States	clinicaltrials.gov
October 22, 2026	NCT07888387	Temporal Interference Stimulation in Major Depressive Disorder: A Pilot Feasibility Study	Ruijin Hospital	Not applicable	Completed	Major Depressive Disorder (MDD)	15	China	clinicaltrials.gov
October 21, 2026	NCT07885722	Evaluation of a Multi-Layered Digital Phenotyping, Digital Safety Plan, and Pharmacogenomic Intervention for Suicide Prevention in Adults...	Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz	Not applicable	Recruiting	Depressive Disorder, Major Depressive Disorder, Suicidal Ideation, Suicide, Attempted, Suicide Prevention	525	Spain	clinicaltrials.gov
October 19, 2026	NCT07881016	French Minds Cohort: a French Longitudinal and Multimodal Cohort of Patients With Major Mood Disorders, Psychotic Disorders, Autism...	Fondation FondaMental	Not applicable	Recruiting	Schizophrenia / Schizoaffective Disorder, First Episode Psychosis (FEP), Bipolar Disorder (BD), Major Depressive...	3,000	France	clinicaltrials.gov
October 19, 2026	NCT07880015	Digital Phenotypes for Predicting Depression_Validation	Korea University Anam Hospital	Observational	Enrolling by invitation	Major Depressive Disorder, Bipolar I Disorder, Bipolar II Disorder, Mood Disorders	200	South Korea	clinicaltrials.gov
October 19, 2026	NCT07879924	Dual Neuromodulation for Depression: Boosting TMS With tES	Mersey Care NHS Trust	Not applicable	Not yet recruiting	Depression - Major Depressive Disorder	60	United Kingdom	clinicaltrials.gov
October 16, 2026	NCT07879131	A Mobile App to Support Mood, Daily Routines and Medication Adherence in Adults With Severe Mental Illness	Alexandria University	Not applicable	Not yet recruiting	Severe Mental Illness, Bipolar Disorder, Schizophrenia, Schizoaffective Disorder, Major Depressive Disorder	60	Bahrain	clinicaltrials.gov
October 15, 2026	NCT07876453	Feasibility and Preliminary Outcomes of Compassion-Focused Group Therapy for Depression and Anxiety	Karolinska Institutet	Not applicable	Completed	Depression / Major Depressive Disorder, Anxiety Disorder (Panic Disorder or GAD)	21	Sweden	clinicaltrials.gov
October 14, 2026	NCT07873905	Digital Single-Session Cognitive Behavioural Therapy in Healthy Adults	Brunel University	Not applicable	Completed	Depression / Major Depressive Disorder, Anxiety, Anxiety Disorder Generalized	110	United Kingdom	clinicaltrials.gov
October 14, 2026	NCT07873060	Comparing 10 Hz rTMS and iTBS for Adolescent Depression	Qilu Hospital of Shandong University	Not applicable	Recruiting	Depressive Disorder, Major Depressive Disorder, Adolescence	80	China	clinicaltrials.gov
October 7, 2026	NCT07862205	EEG-Guided Transcranial Magnetic Stimulation for Adults With Depression	Mayo Clinic	Not applicable	Recruiting	Major Depressive Disorder (MDD), Treatment Resistant Depression, Major Depression	60	United States	clinicaltrials.gov
October 5, 2026	NCT07857629	Brief Psychoanalytic Therapy Versus Cognitive Behavioral Therapy for Major Depressive Disorder	Istanbul Nisantasi University	Not applicable	Not yet recruiting	Major Depressive Disorder (MDD	90	Turkey (Türkiye)	clinicaltrials.gov
October 2, 2026	NCT07853989	Effect of TMS Treatment on Defense Mechanisms and Functionality in Patients With Depression	Namik Kemal University	Observational	Not yet recruiting	Major Depressive Disorder (MDD)	50	Turkey (Türkiye)	clinicaltrials.gov
October 1, 2026	NCT07853365	Predictors of Treatment Outcome in Major Depressive Disorder	Assiut University	Observational	Not yet recruiting	Major Depressive Disorder	100		clinicaltrials.gov
October 1, 2026	NCT07852065	iTBS Versus Standard 10 Hz rTMS for Treatment-Resistant Depression (TRD)	Kafrelsheikh University	Not applicable	Active not recruiting	Major Depression	182	Egypt	clinicaltrials.gov
September 29, 2026	NCT07845604	Precision Depression Adalimumab Trial	Daniel Moriarity	Phase 2	Recruiting	Major Depressive Disorder (MDD)	60	United States	clinicaltrials.gov
September 28, 2026	NCT07843875	Personalized Accelerated iTBS Versus Sham for Major Depressive Disorder	Capital Medical University	Not applicable	Not yet recruiting	Major Depressive Disorder (MDD)	90		clinicaltrials.gov
September 25, 2026	NCT07842601	Helping Kentuckians Overcome Depression and Opioid Addiction With Brain Stimulation	University of Kentucky	Not applicable	Not yet recruiting	Opioid Use Disorder, Major Depressive Disorder (MDD)	60	United States	clinicaltrials.gov
September 22, 2026	NCT07834762	Home-Based Randomized Trial of Spaced Transcranial Direct Current Stimulation for Treatment-Resistant Depression	University of California, San Diego	Not applicable	Not yet recruiting	Treatment Resistant Depression (TRD), Major Depressive Disorder (MDD)	74	United States	clinicaltrials.gov
September 21, 2026	NCT07829575	Amygdala-Targeted Transcranial Temporal Interference Stimulation for Major Depressive Disorder: A Randomized Sham-Controlled Trial of...	Shanghai Pudong New Area Mental Health Center, School of Medicine, Tongji University	Not applicable	Not yet recruiting	Major Depressive Disorder (MDD	60	China	clinicaltrials.gov
September 16, 2026	NCT07823218	Longitudinal Effects of Brain Stimulation on Decision-Making and Reward Learning	University of Bonn	Observational	Not yet recruiting	Depression / Major Depressive Disorder	100	Germany	clinicaltrials.gov
September 10, 2026	NCT07813169	Study on iTBS Regulating the Reward Circuit Function to Improve Anhedonia in Depression	Guo Wenbin	Not applicable	Recruiting	Major Depression, Anhedonia, Melancholic Depression, Theta Burst Stimulation	60	China	clinicaltrials.gov
September 9, 2026	NCT07810023	Intramuscular Ketamine for Suicidal Patients in the Evanston Hospital Emergency Department for Suicidal Distress	Endeavor Health	Not applicable	Enrolling by invitation	Suicidal, Suicidal Ideation, Suicidal Ideation and Behavior, Depression / Major Depressive Disorder	8	United States	clinicaltrials.gov
September 8, 2026	NCT07807930	Individual Narratives of Stimulation (ECT and TMS)	University of Nottingham	Observational	Not yet recruiting	Major Depression	12	United Kingdom	clinicaltrials.gov
September 8, 2026	NCT07807735	Evaluation of an 8-week Behavior Skills-based Virtual Reality Program for Adolescents With Depression. (MDD)	Edward Via Virginia College of Osteopathic Medicine	Not applicable	Not yet recruiting	Major Depression	10	United States	clinicaltrials.gov
September 8, 2026	NCT07806825	Evaluation of the Acceptability, Feasibility and Exploration of the Efficacy of an Integrated Care Pathway CARIBOU	Universidad de los Andes, Chile	Not applicable	Not yet recruiting	Major Depressive Disorder (MDD)	72	Chile	clinicaltrials.gov
September 4, 2026	NCT07804979	Comparison of Efficacy of Minocyclin and Celecoxib as Adjunctive Treatment in Treatment Resistant Cases of Major Depressive Disorder	Lahore General Hospital	Not applicable	Completed	Major Depressive Disorder (MDD), Treatment-resistant Depression (TRD)	78	Pakistan	clinicaltrials.gov
September 4, 2026	NCT07804459	Individualized fMRI-guided TMS for Depression	University of Pennsylvania	Early phase 1	Not yet recruiting	Depression, Major Depressive Disorder (MDD), Depression - Major Depressive Disorder, Persistent Depressive Disorder...	60	United States	clinicaltrials.gov
September 3, 2026	NCT07801703	Behavioural Activation Therapy and Ketamine for Treatment-Resistant Depression	The Royal's Institute of Mental Health Research	Phase 2/3	Recruiting	Treatment Resistant Depression, Major Depressive Disorder (MDD)	60	Canada	clinicaltrials.gov
September 1, 2026	NCT07796295	Prescribing the Right Agent for Depression in Adults	University of Oxford	Not applicable	Not yet recruiting	Major Depressive Disorder (MDD)	2,142	Ethiopia, Pakistan, United Kingdom	clinicaltrials.gov
August 28, 2026	NCT07793071	Oral Thiamine (Vitamin B1) for Depression in Children and Adolescents	Massachusetts General Hospital	Phase 2	Not yet recruiting	Major Depressive Disorder (MDD), Thiamine, Vitamin B1, Thiamine Diphosphate (TDP), Pediatrics	40		clinicaltrials.gov
August 28, 2026	NCT07792252	REWIRE: Real-world Engagement With Interventional and Rejoyn Effectiveness	Yale University	Observational	Not yet recruiting	Major Depressive Disorder (MDD)	50	United States	clinicaltrials.gov
August 27, 2026	NCT07789808	Activating Voice Journaling for Mental Health With Voice Biomarkers	Kintsugi Mindful Wellness, Inc.	Observational	Completed	Depression / Major Depressive Disorder, Anxiety	50,000	United States	clinicaltrials.gov
August 25, 2026	NCT07786285	Adjunctive Probiotic Therapy in Major Depressive Disorder (ProMOOD)	University Maribor	Not applicable	Not yet recruiting	Depression / Major Depressive Disorder	200	Slovenia	clinicaltrials.gov
August 25, 2026	NCT07785102	Single Day of Ultra-accelerated TMS With a Single Dose of NRX-101	Mclean Hospital	Early phase 1	Recruiting	Major Depression	30	United States	clinicaltrials.gov
August 25, 2026	NCT07784244	Early Detection of Perinatal Depression With Wearable Technology	Women's College Hospital	Not applicable	Not yet recruiting	Perinatal Depression	10	Canada	clinicaltrials.gov
August 25, 2026	NCT07783906	Precision Closed-loop Brain-Computer Interface Neuromodulation for Treatment-Resistant Depression	Shanghai Mental Health Center	Not applicable	Not yet recruiting	Treatment-Resistant Major Depressive Disorder, Major Depressive Disorder	70		clinicaltrials.gov
August 25, 2026	NCT07783633	Identifying Biomarkers of Response to Digital Interventions for Mood Disorders	Centre for Addiction and Mental Health	Not applicable	Enrolling by invitation	Depression / Major Depressive Disorder, Bipolar Disorder (BD)	200	Canada	clinicaltrials.gov
August 24, 2026	NCT07781293	Study of Lurasidone as Adjunctive Treatment in Patients With Major Depressive Disorder With Inadequate Response to Antidepressant...	Bukwang Pharmaceutical	Phase 3	Not yet recruiting	Major Depressive Disorder (MDD), Major Depressive Disorder With Psychotic Features	364		clinicaltrials.gov
August 21, 2026	NCT07779707	The Medically Tailored Groceries and Mental Health Study	University of Massachusetts, Worcester	Not applicable	Recruiting	Depression / Major Depressive Disorder, Food Insecurity	300	United States	clinicaltrials.gov
August 20, 2026	NCT07775586	Home-Based Wearable rTMS Therapy for Moderate to Severe Depression	Shanghai Mental Health Center	Not applicable	Not yet recruiting	Major Depressive Disorder	124	China	clinicaltrials.gov
August 20, 2026	NCT07775300	A Study of Brenipatide (LY3537031) in Adult Participants With Major Depressive Disorder	Eli Lilly and Company	Phase 3	Recruiting	Depressive Disorder, Major	1,000	Australia, Brazil, Canada, China, Germany, Greece, Japan, Mexico, Poland...	clinicaltrials.gov
August 19, 2026	NCT07772531	A Study to Evaluate BMS-986511 in Adults With Major Depressive Disorder	Bristol-Myers Squibb	Phase 2	Not yet recruiting	Major Depressive Disorder	200	Czechia, United States	clinicaltrials.gov
August 18, 2026	NCT07771517	Role of Kynurenine Pathway and Its Metabolites in Depressive Disorders, Major Depressive Disorder is Suspected to Have the Greatest Burden...	Sohag University	Observational	Not yet recruiting	Major Depressive Disorder (MDD)	90		clinicaltrials.gov
August 17, 2026	NCT07768397	Accelerated Versus Standard Intermittent Theta Burst Stimulation for Major Depressive Disorder	Military Hospital 175	Not applicable	Recruiting	Major Depressive Disorder	80	Vietnam	clinicaltrials.gov
August 6, 2026	NCT07749521	Optimizing Treatment for Depressed Parents of Children With Emotional and Behavioural Problems	University of Toronto	Not applicable	Recruiting	Depression / Major Depressive Disorder, Conduct Disorders in Children, Disruptive Behaviour in Children, Parenting...	210	Canada	clinicaltrials.gov
August 6, 2026	NCT07748845	Gottman Couple Therapy Program in Treatment of Depressed Female Partners	Tanta University	Not applicable	Completed	Major Depressive Disorder (MDD), Female	40	Egypt	clinicaltrials.gov
August 5, 2026	NCT07748091	EEG Microstate Parameters and Neuroinflammatory Biomarkers in Patients With Treatment-Resistant Major Depressive Disorder Receiving ECT	Istanbul University - Cerrahpasa	Observational	Recruiting	Major Depression Moderate, Major Depression Severe, Major Depression With Comorbid Anxiety Symptoms, Major Depression...	62	Turkey (Türkiye)	clinicaltrials.gov
August 5, 2026	NCT07747389	A Study of Lumateperone Versus Placebo in Participants With Major Depressive Disorder	Intra-Cellular Therapies, Inc.	Phase 3	Not yet recruiting	Depressive Disorder, Major	585		clinicaltrials.gov
August 4, 2026	NCT07745569	Assessing of Behavioral Risk and Response to Electromagnetic and Psychedelic Therapies	University of New Mexico	Phase 2	Not yet recruiting	PTSD, PTSD - Post Traumatic Stress Disorder, Major Depression, Suicidality	150		clinicaltrials.gov
August 4, 2026	NCT07744490	Tracking Risk in Adolescents and Children for Early Identification of Common Mental Disorders	Shanghai Mental Health Center	Observational	Not yet recruiting	High Risk, Depression / Major Depressive Disorder, Anxiety Disease, Obsessive - Compulsive Disorder	200	China	clinicaltrials.gov
August 3, 2026	NCT07743398	Context-Guided Personalized iTBS for Depression	Capital Medical University	Not applicable	Not yet recruiting	Major Depressive Disorder (MDD)	60	China	clinicaltrials.gov
August 3, 2026	NCT07741331	Compare the Efficacy and Safety of KH607 Tablets Versus Vortioxetine Hydrobromide Tablets in Adult Patients With Major Depressive Disorder	Chengdu Kanghong Pharmaceutical Group Co., Ltd.	Phase 3	Not yet recruiting	Major Depressive Disorder (MDD)	326		clinicaltrials.gov
August 3, 2026	NCT07741240	A Study of KH607 as Monotherpy in Adults Participants With Major Depressive Disorder	Chengdu Kanghong Pharmaceutical Group Co., Ltd.	Phase 3	Not yet recruiting	Major Depressive Disorder (MDD)	232		clinicaltrials.gov
July 31, 2026	NCT07740694	EEG Microstate and Neuroinflammatory Biomarkers in Older Age Patients With Major Depressive Disorder Receiving ECT	Istanbul University - Cerrahpasa	Observational	Recruiting	Major Depression Moderate, Major Depression Severe, Major Depression With Comorbid Anxiety Symptoms, Major Depression...	62	Turkey (Türkiye)	clinicaltrials.gov
July 31, 2026	NCT07738497	Biomarkers and Pharmacogenomics for Precision Depression Therapy	The Fourth Affiliated Hospital of Zhejiang University School of Medicine	Not applicable	Not yet recruiting	Depression / Major Depressive Disorder	220		clinicaltrials.gov
July 29, 2026	NCT07735143	iMORE+ Study: A Multi-Omics Cohort Study of Major Depressive Disorder	Shanghai Mental Health Center	Observational	Not yet recruiting	Major Depressive Disorder (MDD)	150	China	clinicaltrials.gov
July 29, 2026	NCT07734701	Pregnenolone Treatment for Alcohol Use Disorder and Major Depressive Disorder	Sherwood Brown, MD, PhD	Phase 2	Not yet recruiting	Alcohol Use Disorder (AUD), Major Depressive Disorder (MDD)	100	United States	clinicaltrials.gov
July 29, 2026	NCT07733310	Augmented Depression Therapy (ADepT) Case Series	Ohio State University	Not applicable	Not yet recruiting	Depression / Major Depressive Disorder	40	United States	clinicaltrials.gov
July 27, 2026	NCT07728253	Probiotic IBNI617 for Moderate to Severe Depression	IBIOME BIOTECHNOLOGY CO., LTD	Not applicable	Not yet recruiting	Major Depressive Disorder (MDD), IBNI617	148	China	clinicaltrials.gov
July 27, 2026	NCT07727005	Effectiveness of Clustered Versus Tapered Repetitive Transcranial Magnetic Stimulation (rTMS) as Maintenance Therapy Following Successful...	Technical University of Munich	Not applicable	Not yet recruiting	Major Depressive Disorder (MDD), Depressive Episodes, Depressive Syndrome	100	Germany	clinicaltrials.gov
July 17, 2026	NCT07712159	Temporal Interference Transcranial Alternating Current Stimulation for Major Depressive Disorder	Central South University	Not applicable	Not yet recruiting	Major Depressive Disorder (MDD)	102		clinicaltrials.gov
July 14, 2026	NCT07703722	Effect of Psilocybin and Structured Integrated Reframing Therapy on Gut-Brain Axis Biomarkers and Depression in Major Depressive Disorder	Khyber Medical University Peshawar	Phase 3	Recruiting	Major Depressive Disorder, Post-Traumatic Stress Disorder (PTSD)	60	Pakistan	clinicaltrials.gov
July 10, 2026	NCT07696871	Cannabidiol Oil for Treatment-Resistant Major Depression	Universidade do Sul de Santa Catarina	Phase 1/2	Recruiting	Major Depressive Disorder (MDD), Treatment-resistant Depression (TRD)	120	Brazil	clinicaltrials.gov
July 9, 2026	NCT07694076	Mechanisms of Repeated Real-time Biofeedback With 7-Tesla MRI in Depression	University of Oxford	Not applicable	Recruiting	Major Depressive Disorder (MDD)	60	United Kingdom	clinicaltrials.gov
July 9, 2026	NCT07691749	Effect of Psychobiotics With Standard Antiddepressants in Treatment of Major Depressive Disorder	Dr Sadia yasir	Not applicable	Recruiting	Major Depression	86	Pakistan	clinicaltrials.gov
July 6, 2026	NCT07685964	Pregnenolone for Cannabis Use Disorder and Depression	University of Texas Southwestern Medical Center	Phase 1/2	Not yet recruiting	Cannabis Use Disorder, Major Depressive Disorder (MDD)	20	United States	clinicaltrials.gov
July 6, 2026	NCT07685925	Intern Health Study 2026	University of Michigan	Not applicable	Enrolling by invitation	Depression / Major Depressive Disorder, Mood, Sleep, Physical Activity	1,000	United States	clinicaltrials.gov
July 6, 2026	NCT07684911	Longitudinal Study on the Sustainability of Transcranial Magnetic Stimulation Protocols - Biomarkers	Hospital Center Guillaume Régnier	Observational	Recruiting	Depression - Major Depressive Disorder, Depression Bipolar, Depression Unipolar	30	France	clinicaltrials.gov
July 6, 2026	NCT07684794	Regulated Stimulation for Optimized Network Activity and Therapeutic Equilibrium - Maintenance	Motif Neurotech, Inc.	Not applicable	Not yet recruiting	Major Depressive Disorder (MDD)	10		clinicaltrials.gov
July 6, 2026	NCT07684677	Effect of Participating in a Study of Causes of Pregnancy Loss on Mental Health Outcomes: A Target Trial Emulation Using the COPL Cohort...	Amager Hospital	Not applicable	Active not recruiting	Pregnancy Loss, Early, Major Depression, Anxiety, Stress (Psychology)	30,000	Denmark	clinicaltrials.gov
July 2, 2026	NCT07682207	Accelerated iTBS for PTSD and Depression	Lawson Research Institute of St. Joseph's	Not applicable	Recruiting	Post Traumatic Stress Disorder PTSD, Major Depressive Disorder (MDD)	16	Canada	clinicaltrials.gov
July 1, 2026	NCT07679204	Type D Personality and Life Satisfaction in Bipolar Disorder Type 2 and Major Depressive Disorder	Elazığ Mental Health and Diseases Hospital	Observational	Recruiting	Bipolar Disorder II, Major Depressive Disorder (MDD)	180	Turkey (Türkiye)	clinicaltrials.gov
June 29, 2026	NCT07673913	Relationship of Peripheral Inflammatory and Neuroprotective Biomarkers With Response to Intermittent Theta Burst Stimulation in...	Gulhane Training and Research Hospital	Not applicable	Recruiting	Treatment-resistant Depression (TRD), Major Depression	100	Turkey (Türkiye)	clinicaltrials.gov
June 16, 2026	NCT07651293	Using Fenfluramine to Test the Serotonin Deficiency Theory of Depression	Imperial College Healthcare NHS Trust	Not applicable	Not yet recruiting	Depression - Major Depressive Disorder	46	United Kingdom	clinicaltrials.gov
June 16, 2026	NCT07649993	Non-Coding RNAs Gene Expression in Psychiatric Disorders	Carmen Concerto	Observational	Not yet recruiting	Schizophrenia Disorders, Major Depression, Bipolar Affective Disorders, Obsessive Compulsive Disorder (OCD), Anxiety...	384	Italy	clinicaltrials.gov
June 12, 2026	NCT07645157	Sertraline Combined With Multi-Strain Probiotics for Adolescent Depression	First Affiliated Hospital of Chongqing Medical University	Phase 2	Recruiting	Major Depressive Disorder (MDD), Probiotic Intervention	120	China	clinicaltrials.gov
June 10, 2026	NCT07639164	Stronger Together: Antenatal Depressive Symptoms - Prevalence and Digital Treatment	University of Turku	Not applicable	Not yet recruiting	Depression / Major Depressive Disorder, Antenatal Depression	1,000	Finland	clinicaltrials.gov
June 10, 2026	NCT07638202	Transcranial Magnetic Stimulation in Depression.	Instituto Mexicano del Seguro Social	Not applicable	Completed	Major Depressive Disorder (MDD)	40	Mexico	clinicaltrials.gov
June 8, 2026	NCT07634458	Serotonin Variants & Gut Microbiota in Mental Health	Neurobiologix	Observational	Not yet recruiting	Major Depressive Disorder (MDD, Anxiety Disorder, Generalized, Stress Disorders, Post-Traumatic, Panic Disorder	30		clinicaltrials.gov
June 8, 2026	NCT07633080	Magnesium Bisglycinate in Major Depressive Disorder	All India Institute of Medical Sciences, Bhubaneswar	Not applicable	Recruiting	Major Depressive Disorder	84	India	clinicaltrials.gov
June 5, 2026	NCT07629050	Functional Electrical Stimulation for MDD	Unity Health Toronto	Not applicable	Not yet recruiting	MDD	60		clinicaltrials.gov
June 4, 2026	NCT07628192	Youth Suicide Prevention: CAMS-BI vs. Safety Planning in a Randomized Trial	The Cleveland Clinic	Not applicable	Not yet recruiting	Suicidal Ideation, Suicide Attempt, Safety Plan, Depression / Major Depressive Disorder, Hopelessness	118	United States	clinicaltrials.gov
June 4, 2026	NCT07625163	The Effects of Aerobic Exercise and Mindful Breathing on Individuals With Major Depressive Disorder in Saudi Arabia	University of Pretoria	Not applicable	Not yet recruiting	Major Depressive Disorder (MDD)	60	Saudi Arabia	clinicaltrials.gov
June 3, 2026	NCT07623135	Lumateperone for Late-Life Depression	Eric Lenze	Phase 3	Recruiting	Treatment Resistant Depression (TRD), Late Life Depression (LLD), Depression / Major Depressive Disorder	100	United States	clinicaltrials.gov

Sponsors posting most

Sponsor	New trials	Latest
Stanford University	7	April 14, 2026
Centre for Addiction and Mental Health	6	August 25, 2026
Neurocrine Biosciences	6	September 29, 2025
University of California, San Diego	5	September 22, 2026
Shanghai Mental Health Center	5	August 25, 2026
Sunnybrook Health Sciences Centre	5	January 29, 2026
VA Office of Research and Development	4	October 26, 2026
Mclean Hospital	4	August 25, 2026
Istanbul University - Cerrahpasa	4	August 5, 2026
Central South University	4	July 17, 2026
Janssen Research & Development, LLC	4	May 7, 2026
Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau	4	January 2, 2026
Capital Medical University	3	November 6, 2026
Ruijin Hospital	3	October 22, 2026
University of Pennsylvania	3	September 4, 2026
Tanta University	3	August 6, 2026
Chengdu Kanghong Pharmaceutical Group Co., Ltd.	3	August 3, 2026
Unity Health Toronto	3	June 5, 2026
The Second Hospital of Anhui Medical University	3	April 28, 2026
Peking University Sixth Hospital	3	April 2, 2026

By phase

Phase	New trials	Latest
Not applicable	200	November 9, 2026
Observational	65	November 9, 2026
Phase 2	41	November 2, 2026
Phase 3	37	August 24, 2026
Phase 1	11	April 24, 2026
Phase 4	10	April 29, 2026
Early phase 1	7	September 4, 2026
Phase 1/2	7	July 10, 2026
Phase 2/3	2	September 3, 2026

By country

Country	New trials	Latest
United States	128	November 9, 2026
China	48	November 9, 2026
Canada	35	October 30, 2026
Spain	19	October 21, 2026
France	16	October 19, 2026
Turkey (Türkiye)	15	October 5, 2026
Germany	15	September 16, 2026
United Kingdom	14	October 19, 2026
Poland	12	August 20, 2026
Czechia	10	August 19, 2026
Pakistan	9	September 4, 2026
Australia	9	August 20, 2026
Taiwan	9	August 20, 2026
Italy	9	June 16, 2026
Brazil	8	August 20, 2026
Bulgaria	8	March 5, 2026
Denmark	7	November 5, 2026
Switzerland	7	January 16, 2026
Romania	6	October 23, 2026
South Korea	6	October 19, 2026
Egypt	6	October 1, 2026
Belgium	5	November 9, 2026
Finland	5	June 10, 2026
Israel	5	February 10, 2026
Hungary	5	November 12, 2025

Where the register publishes

U.S. government data; ClinicalTrials.gov terms of use. Studies are as their sponsors registered them on ClinicalTrials.gov, read through its API. Condition groups are the MeSH terms ClinicalTrials.gov assigns to each study's conditions; a study with several is in several groups. Sponsor class is the register's class of the lead sponsor. The central contact is in the full list only as the record prints it. Free to reuse with credit to SpecStream under CC BY 4.0. Spot a wrong value? Write to [email protected] with the link to this page.