Data / New clinical trials / Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis trials: 171 new since Nov 2024

Name: New Amyotrophic Lateral Sclerosis clinical trials
Creator: SpecStream
License: https://creativecommons.org/licenses/by/4.0/

The full list. New Amyotrophic Lateral Sclerosis clinical trials: 171 rows for $8.55, first posted on ClinicalTrials.gov from November 12, 2024 to November 9, 2026. The list gains about 7 rows a month. The new rows come each week by email, $19 a month.

Pay by card with no account. Prices exclude VAT. CSV and Excel files with the columns this page does not show (central contact, contact phone, contact email, sponsor class, condition groups (MeSH), interventions and 5 more), which open on your screen as soon as the payment clears and come by email. The weekly rows run until you cancel, from the link in each delivery. The rows on this page are a sample.

For agents and scripts: this list is ordered at https://specstream.ai/data/clinical-trials/condition/amyotrophic-lateral-sclerosis, and every list with its row count and price is at https://specstream.ai/data/lists.json.

Updated November 6, 2026. Source: ClinicalTrials.gov API v2 (U.S. National Library of Medicine).

171 clinical studies in Amyotrophic Lateral Sclerosis were first posted on ClinicalTrials.gov from November 15, 2024 to November 6, 2026; 58 have an industry sponsor and 127 are recruiting or about to. The newest, NCT07922031, was posted on November 6, 2026: A Study on the Addition of Alsum30 for the Treatment of Amyotrophic Lateral Sclerosis (Liu Qing).

The request: Every new Amyotrophic Lateral Sclerosis clinical trial on ClinicalTrials.gov, with the sponsor, phase, sites and the listed contact. $10 of credit on sign-up, no card.

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SpecStream is the live web data engine for teams and agents. It reads every new study on ClinicalTrials.gov each morning, and this page is that reading. Ask for the conditions, phases or countries you follow and each new trial arrives in your sheet, CRM, Slack or agent with the sponsor, the sites and the listed contact.

171New trials
58Industry sponsored
127Recruiting or not yet
November 6, 2026Latest posted

Newest trials

The newest 100 of 171, each linked to its record. The full list holds every one with the sponsor class, interventions, start date and the central contact as the record prints it.

First posted	NCT ID	Title	Sponsor	Phase	Status	Conditions	Enrollment	Countries	Source
November 6, 2026	NCT07922031	A Study on the Addition of Alsum30 for the Treatment of Amyotrophic Lateral Sclerosis	Liu Qing	Not applicable	Not yet recruiting	Amyotrophic Lateral Sclerosis (ALS), Bacillus Coagulans, Dietary Supplement, Sulforaphane	15		clinicaltrials.gov
October 30, 2026	NCT07906665	A Study of Single Ascending Doses of NI112 in Adults With Amyotrophic Lateral Sclerosis (ALS)	Sachi Bioworks Inc.	Phase 1	Not yet recruiting	Amyotrophic Lateral Sclerosis (ALS)	40	United States	clinicaltrials.gov
October 28, 2026	NCT07900672	Register for Medical Data, Functional Scales, and Care Outcomes in ALS, SMA, and Other Motor System Disorders	Ambulanzpartner Soziotechnologie APST GmbH	Observational	Recruiting	ALS (Amyotrophic Lateral Sclerosis), SMA - Spinal Muscular Atrophy, Spinal Cord Diseases, Central Nervous System...	2,000	Germany	clinicaltrials.gov
October 20, 2026	NCT07883590	A Study of LY3873862 in Participants With Sporadic or Familial Amyotrophic Lateral Sclerosis (ALS).	Eli Lilly and Company	Phase 1	Not yet recruiting	Amyotrophic Lateral Sclerosis, Cytochrome P-450 Enzyme System	32	Canada, United States	clinicaltrials.gov
October 15, 2026	NCT07875972	Safety, Tolerability, and Pharmacodynamic Exploration of Orelabrutinib in Patients With Amyotrophic Lateral Sclerosis (ALS)	Liu Qing	Phase 1	Not yet recruiting	Amyotrophic Lateral Sclerosis (ALS)	18		clinicaltrials.gov
October 13, 2026	NCT07871071	Brain-Computer Interface Communication Device for People With ALS	Cognixion	Not applicable	Recruiting	Amyotrophic Lateral Sclerosis	30	United States	clinicaltrials.gov
October 8, 2026	NCT07865260	PhiCube for Bilateral Upper Limb Neuromotor and Cognitive Rehabilitation in Adults	Istituto di Sistemi e Tecnologie Industriali Intelligenti per il Manifatturiero Avanzato	Not applicable	Not yet recruiting	Stroke, Parkinson Disease, Amyotrophic Lateral Sclerosis, Spinal Cord Injuries, Mild Cognitive Impairment, Upper...	80	Italy	clinicaltrials.gov
October 7, 2026	NCT07862959	Early Access Program for Ulefnersen in Children, Adolescents and Adults With FUS-associated Amyotrophic Lateral Sclerosis (FUS-ALS)	Otsuka Pharmaceutical Development & Commercialization, Inc.	Not applicable	Available	Amyotrophic Lateral Sclerosis	Not listed		clinicaltrials.gov
October 2, 2026	NCT07855211	A Study to Learn About the Safety of BIIB147 and Its Effects in Adults With Amyotrophic Lateral Sclerosis (ALS)	Biogen	Phase 1/2	Recruiting	Amyotrophic Lateral Sclerosis	69	United States	clinicaltrials.gov
October 1, 2026	NCT07851714	Metabolism and Nutrition in MND	Guy's and St Thomas' NHS Foundation Trust	Observational	Not yet recruiting	Amyotrophic Lateral Sclerosis (ALS), Motor Neurone Disease (MND)	12	United Kingdom	clinicaltrials.gov
September 28, 2026	NCT07844590	Developing New Ways to Detect Respiratory Impairment Early in ALS	Thomas Jefferson University	Observational	Recruiting	Amyotrophic Lateral Sclerosis (ALS)	70	United States	clinicaltrials.gov
September 24, 2026	NCT07838389	Evaluation of Donor-Derived B Cell Infusions in Patients With Amyotrophic Lateral Sclerosis (ALS)	Mark Poznansky	Phase 1	Not yet recruiting	ALS - Amyotrophic Lateral Sclerosis	10	United States	clinicaltrials.gov
September 23, 2026	NCT07836751	Using Gaze to Enable Head-neck Movements in Patients With Head Drop	University of Utah	Not applicable	Recruiting	Amyotrophic Lateral Sclerosis & Other Neuromuscular Disorders	12	United States	clinicaltrials.gov
September 22, 2026	NCT07834450	Efficacy and Safety of Cyclophosphamide in Amyotrophic Lateral Sclerosis	Huashan Hospital	Phase 2	Not yet recruiting	Amyotrophic Lateral Sclerosis	60		clinicaltrials.gov
September 22, 2026	NCT07833618	A Phase II Study of ALT001 in Patients With Amyotrophic Lateral Sclerosis (ALS)	Darwin Origin (Hubei) Biopharmaceutical Co., Ltd.	Phase 2	Not yet recruiting	Amyotrophic Lateral Sclerosis (ALS)	150	China	clinicaltrials.gov
September 16, 2026	NCT07823101	Imaging Assessment of Swallowing and Speech Muscles in Inclusion Body Myositis	Johns Hopkins University	Observational	Recruiting	IBM, Inclusion Body Myositis, Myopathy, Myositis, ALS (Amyotrophic Lateral Sclerosis), PLS	30	United States	clinicaltrials.gov
September 15, 2026	NCT07819890	Development in Home Mechanical Ventilation for Patient With Amyotrophic Lateral Sclerosis.	Copenhagen University Hospital, Rigshospitalet	Observational	Not yet recruiting	Amyotrophic Lateral Sclerosis, Home Mechanical Ventilation	400		clinicaltrials.gov
September 14, 2026	NCT07818772	7T Imaging Pilot-study in Patients With Motor Neuron Disease to Find Non-Invasive Disease Imaging Biomarkers	NHS Greater Glasgow and Clyde	Observational	Recruiting	ALS - Amyotrophic Lateral Sclerosis	30	United Kingdom	clinicaltrials.gov
September 10, 2026	NCT07813858	Colchicine Effect on Amyotrophic Lateral Sclerosis Patients	Azienda Ospedaliero-Universitaria di Modena	Phase 2	Not yet recruiting	Amyotrophic Lateral Sclerosis	87	Italy	clinicaltrials.gov
September 1, 2026	NCT07798700	Biofluid Research on Age-Related or Inherited Neurodegeneration	University of Pennsylvania	Observational	Recruiting	Frontotemporal Degeneration (FTD), ALS (Amyotrophic Lateral Sclerosis), Primary Progressive Aphasia (PPA), Familial...	1,000	United States	clinicaltrials.gov
September 1, 2026	NCT07796776	The Aim of the Study is to Characterize Patients Exhibiting Muscular Atrophy and Weakness Who Require a Muscle Biopsy for Diagnosis (IBM vs...	IRCCS San Raffaele	Observational	Active not recruiting	Inclusion Body Myositis (IBM), Motor Neuron Disease, Amyotrophic Lateral Sclerosis	30	Italy	clinicaltrials.gov
August 3, 2026	NCT07743268	Personalized Antisense Oligonucleotide Therapy for Participants With TARDBP ALS	n-Lorem Foundation	Phase 1/2	Enrolling by invitation	Amyotrophic Lateral Sclerosis (ALS)	6	United States	clinicaltrials.gov
July 30, 2026	NCT07737977	Developing a Comprehensive Biomarker Panel for Monitoring Progression and Early Detection in ALS Patients	University Hospital, Montpellier	Observational	Not yet recruiting	ALS (Amyotrophic Lateral Sclerosis)	200	France, Spain	clinicaltrials.gov
July 24, 2026	NCT07726563	Plasmapheresis in Amyotrophic Lateral Sclerosis With Autoantibody Against NRIP 2 (PALADIN2)	National Taiwan University Hospital	Not applicable	Recruiting	Amyotrophic Lateral Sclerosis (ALS), Autoantibody, Plasmapheresis	20	Taiwan	clinicaltrials.gov
July 15, 2026	NCT07706270	Serum Neurofilaments in the Diagnosis of Amyotrophic Lateral Sclerosis	University Hospital, Montpellier	Observational	Not yet recruiting	Amyotrophic Lateral Sclerosis (ALS), Neurodegenerative Disorders, Motor Neuron Diseases	138		clinicaltrials.gov
July 14, 2026	NCT07703462	Personalized Antisense Oligonucleotide Therapy for a Participant With TARDBP ALS	n-Lorem Foundation	Phase 1/2	Enrolling by invitation	Amyotrophic Lateral Sclerosis (ALS)	1	United States	clinicaltrials.gov
July 13, 2026	NCT07698496	Evaluation of the Feasibility and Efficacy of a Chronic Brain-computer Interface for Speech Rehabilitation in Patients With...	University Hospital, Grenoble	Not applicable	Not yet recruiting	Locked in Syndrome, ALS (Amyotrophic Lateral Sclerosis)	3	France	clinicaltrials.gov
July 7, 2026	NCT07688239	The BANYAN Trial, an ALS MyMatch Trial Evaluating Safety, Biomarker Activity, and Microglial Activation of Nasal Foralumab	Tiziana Life Sciences LTD	Phase 2	Enrolling by invitation	ALS (Amyotrophic Lateral Sclerosis), ALS - Amyotrophic Lateral Sclerosis, ALS	44	United States	clinicaltrials.gov
July 2, 2026	NCT07680361	Study of Home Use of the Jaco Robotic Manipulation Device by Individuals With Tetraplegia	Association APPROCHE	Not applicable	Completed	Tetraplegia, Functional Tetraplegia, Spinal Cord Injury, Muscular Dystrophy, ALS (Amyotrophic Lateral Sclerosis)...	18	France	clinicaltrials.gov
June 29, 2026	NCT07674667	FUNCtion ALS: Aiming to Restore UNC13A Function in People Living With ALS	Trace Neuroscience, Inc.	Phase 1/2	Recruiting	Amyotrophic Lateral Sclerosis	30	Germany, Netherlands, United Kingdom	clinicaltrials.gov
June 22, 2026	NCT07660614	A Study of LTX-002 in Adult Participants With Amyotrophic Lateral Sclerosis	Leal Therapeutics, Inc	Phase 1/2	Recruiting	Amyotrophic Lateral Sclerosis	56	Germany, Italy, Netherlands, Sweden	clinicaltrials.gov
June 18, 2026	NCT07656714	HFCWO Vest Plus Mechanical Cough Assist Versus Cough Assist Alone on Respiratory Infections in ALS: a Pilot Trial	Hospital Universitario Virgen Macarena	Not applicable	Completed	Amyotrophic Lateral Sclerosis, Respiratory Infection	14	Spain	clinicaltrials.gov
June 9, 2026	NCT07636538	Auto-calibrating System for Upper Limb Disability Assessment, Neurological and Occupational Rehabilitation	University of Pavia	Not applicable	Not yet recruiting	Stroke, Amyotrophic Lateral Sclerosis, PARKINSON DISEASE (Disorder), Mild Cognitive Impairment (MCI)	30		clinicaltrials.gov
June 4, 2026	NCT07625605	The Meals Study for Amyotrophic Lateral Sclerosis and Parkinson's Disease	The University of Tennessee, Knoxville	Not applicable	Completed	Amyotrophic Lateral Sclerosis (ALS), Parkinson's Disease (PD)	43	United States	clinicaltrials.gov
June 1, 2026	NCT07618585	Safety and Efficacy of Intrathecal NTF001 Injection in ALS	Ruijin Hospital	Phase 1	Active not recruiting	ALS - Amyotrophic Lateral Sclerosis, ALS (Amyotrophic Lateral Sclerosis)	12	China	clinicaltrials.gov
May 29, 2026	NCT07616050	Evaluation of the Impact of Virtual Park on Training Motivation in Adult Patients	Marta Mondellini	Not applicable	Not yet recruiting	Post-stroke, Parkinson Disease, Amyotrophic Lateral Sclerosis, Mild Cognitive Impairment (MCI), Multiple Sclerosis...	70	Italy	clinicaltrials.gov
May 26, 2026	NCT07606235	Transcutaneous Superior Laryngeal Nerve Stimulation to Upregulate Swallowing Frequency and Urge to Swallow in Patients Living With ALS	Nova Southeastern University	Not applicable	Not yet recruiting	Amyotrophic Lateral Sclerosis (ALS), Dysphagia, Dystussia	5		clinicaltrials.gov
May 19, 2026	NCT07595666	Comparison of NeuroEXPLORER PET/CT Versus Standard-of-care PET/CT of the Head and Neck Region.	prof. dr. Koen Van Laere	Not applicable	Enrolling by invitation	Dementia, Movement Disorders, ALS - Amyotrophic Lateral Sclerosis, Epilepsy, Brain Tumors, Pituitary Adenoma, Large...	1,600	Belgium	clinicaltrials.gov
May 15, 2026	NCT07589764	Pilot Trial Utilizing β-hydroxy-β-methylbutyrate to Lower IGFBP7 Levels in People With ALS	Duke University	Phase 1	Not yet recruiting	Amyotrophic Lateral Sclerosis ALS	100	United States	clinicaltrials.gov
May 7, 2026	NCT07572838	Alter-Ego as an Assistive Robotic Device.	University of Pisa	Observational	Completed	Amyotrophic Lateral Sclerosis, Health Adult Subjects	52	Italy	clinicaltrials.gov
May 6, 2026	NCT07571486	Therapeutic Approach of Repeated Transient Blood-brain Barrier Opening in Amyotrophic Lateral Sclerosis.	Assistance Publique - Hôpitaux de Paris	Phase 1/2	Recruiting	Amyotrophic Lateral Sclerosis, Charcot Disease	23	France	clinicaltrials.gov
May 6, 2026	NCT07571200	A Master Protocol (OLMP): A Study of LY4256984 in Participants With Amyotrophic Lateral Sclerosis (ALS)	Eli Lilly and Company	Phase 1	Recruiting	Amyotrophic Lateral Sclerosis	32	Belgium, Canada, Germany, Netherlands, Spain	clinicaltrials.gov
May 6, 2026	NCT07571174	A Substudy of LY4256984 in Participants With Sporadic Amyotrophic Lateral Sclerosis	Eli Lilly and Company	Phase 1	Recruiting	Amyotrophic Lateral Sclerosis	32	Belgium, Canada, Germany, Netherlands, Spain	clinicaltrials.gov
May 5, 2026	NCT07567664	Tracking and Predicting How Brain Damage Spreads in Neurodegenerative Diseases	IRCCS San Raffaele	Not applicable	Enrolling by invitation	Neurodegenerative Disease, Behavioral Variant Frontotemporal Dementia (bvFTD), Primary Progressive Aphasia(PPA)...	645	Italy	clinicaltrials.gov
April 21, 2026	NCT07543367	INdependence Through Endovascular Neuroprosthetic Technology (INTENT): an Early Feasibility Study	Synchron, Inc.	Not applicable	Active not recruiting	Neurological Disorder, ALS (Amyotrophic Lateral Sclerosis), Motor Neuron Disease, ALS - Amyotrophic Lateral Sclerosis...	10	United States	clinicaltrials.gov
April 20, 2026	NCT07539662	Unrelated Umbilical Cord Blood Transplantation for the Treatment of Amyotrophic Lateral Sclerosis (ALS)	Institute of Hematology & Blood Diseases Hospital, China	Not applicable	Enrolling by invitation	ALS (Amyotrophic Lateral Sclerosis)	8	China	clinicaltrials.gov
April 16, 2026	NCT07533903	Functional Outcomes and Control Using Synchron BCI - Australia	Synchron, Inc.	Not applicable	Active not recruiting	Neurologic Disorder, Neurologic Diseases, MND (Motor Neurone DIsease), Motor Neuron Disease, Motor Neuron Disease...	10	Australia	clinicaltrials.gov
April 13, 2026	NCT07521930	Interfacing With NeuroTechnology to Expand Neural Throughput (INTENT)	Johns Hopkins University	Not applicable	Recruiting	Tetraplegia/Tetraparesis, Amyotrophic Lateral Sclerosis (ALS), Muscular Disorders, Atrophic, Brain Stem Stroke, Spinal...	5	United States	clinicaltrials.gov
April 3, 2026	NCT07509125	Ultra-High Resolution PET in Aging, Neurodegeneration and Psychotic Disorders	Universitaire Ziekenhuizen KU Leuven	Not applicable	Recruiting	Alzheimer Dementia (AD), ALS - Amyotrophic Lateral Sclerosis, Parkinson s Disease, REM Sleep Behavior Disorder (iRBD)...	300	Belgium	clinicaltrials.gov
March 31, 2026	NCT07502677	Diagnostic Accuracy of SleepImage Technology for Detecting Respiratory Failure in Patients With Amyotrophic Lateral Sclerosis	Royal Brompton & Harefield NHS Foundation Trust	Observational	Recruiting	Amyotrophic Lateral Sclerosis	15	United Kingdom	clinicaltrials.gov
March 24, 2026	NCT07491562	Evaluation of a Structurally Suitable Neck Exoskeleton in Patients With Amyotrophic Lateral Sclerosis	University of Utah	Not applicable	Completed	ALS - Amyotrophic Lateral Sclerosis	10	United States	clinicaltrials.gov
March 24, 2026	NCT07491484	Impact of Physical Functioning on Patient-Reported Outcomes in ALS Patients at TidalHealth	TidalHealth, Inc.	Observational	Recruiting	Amyotrophic Lateral Sclerosis, Motor Neuron Disease	30	United States	clinicaltrials.gov
March 18, 2026	NCT07479017	Characterization of Platelet Molecular Profiles in ALS for the Identification of Specific Diagnostic Biomarkers - A Pilot Study	University Hospital, Tours	Observational	Not yet recruiting	ALS (Amyotrophic Lateral Sclerosis)	60	France	clinicaltrials.gov
March 17, 2026	NCT07478172	Effects of Whole-body Electrical Muscle Stimulation Exercise on Adults With Neuromuscular Disease	University of Missouri-Columbia	Not applicable	Active not recruiting	Neuromuscular Diseases (NMD), Amyotrophic Lateral Sclerosis, Myasthenia Gravis, Lambert-eaton Myasthenic Syndrome...	50	United States	clinicaltrials.gov
March 16, 2026	NCT07473765	Virtual Reality for Anxiety Management in Persons With Amyotrophic Lateral Sclerosis	Horizon Health Network	Not applicable	Not yet recruiting	ALS (Amyotrophic Lateral Sclerosis)	60		clinicaltrials.gov
March 12, 2026	NCT07467746	Research of Traditional Chinese Medicine Oral Preparation of C. Cicadae in the Treatment of ALS Patients With Elevated Plasma Sphingolipids	The Third Xiangya Hospital of Central South University	Phase 2	Not yet recruiting	Amyotrophic Lateral Sclerosis	84		clinicaltrials.gov
March 12, 2026	NCT07467187	Invasive Home Ventilation in Denmark	Copenhagen University Hospital, Rigshospitalet	Observational	Recruiting	Neuromuscular Diseases (NMD), ALS (Amyotrophic Lateral Sclerosis), Spinal Cord Injuries (SCI), Duchenne Muscular...	450	Denmark	clinicaltrials.gov
March 6, 2026	NCT07454733	Do Video Recordings of Multidisciplinary Clinics Improve Quality of Life for People With ALS and Their Caregivers?	Trustees of Dartmouth College	Not applicable	Recruiting	Amyotrophic Lateral Sclerosis (ALS)	800	United States	clinicaltrials.gov
February 20, 2026	NCT07423494	Personalized Antisense Oligonucleotide Therapy for A Single Patient With CHCHD10 ALS (nL18576)	n-Lorem Foundation	Phase 1/2	Not yet recruiting	Amyotrophic Lateral Sclerosis	1	United States	clinicaltrials.gov
February 17, 2026	NCT07414212	Evaluation of the Combined Therapy of EH-301 and N-acetylcysteine Together With Riluzole in Amyotrophic Lateral Sclerosis (ALS)	Biogipuzkoa Health Research Institute	Phase 1/2	Recruiting	Amyotrophic Lateral Sclerosis	90	Spain	clinicaltrials.gov
February 13, 2026	NCT07410806	HEALEY ALS Platform Trial - Regimen I NUZ-001	Merit E. Cudkowicz, MD	Phase 2/3	Active not recruiting	Amyotrophic Lateral Sclerosis (ALS)	240	United States	clinicaltrials.gov
February 12, 2026	NCT07407725	Clinical Outcome Assessment for AT & BCI	Shirley Ryan AbilityLab	Not applicable	Recruiting	Spinal Cord Injury, ALS (Amyotrophic Lateral Sclerosis)	60	United States	clinicaltrials.gov
February 10, 2026	NCT07401121	Safety and Tolerability Study of CTx1000 In Participants With Amyotrophic Lateral Sclerosis	Celosia Therapeutics Pty Ltd	Phase 1	Recruiting	ALS (Amyotrophic Lateral Sclerosis)	15	Australia	clinicaltrials.gov
February 10, 2026	NCT07400393	Healey ALS MyMatch Common Screening Protocol	Massachusetts General Hospital	Observational	Not yet recruiting	ALS, ALS (Amyotrophic Lateral Sclerosis), ALS - Amyotrophic Lateral Sclerosis	500		clinicaltrials.gov
February 9, 2026	NCT07396818	Kamlanoflast In Amyotrophic Lateral Sclerosis	Inflammasome Therapeutics	Phase 1/2	Not yet recruiting	ALS (Amyotrophic Lateral Sclerosis), ALS, Neuro-Degenerative Disease, Neuro-Degenerative Diseases, Motor Neuron Disease...	40		clinicaltrials.gov
February 6, 2026	NCT07393932	MND Together: Phase 1	University of Sheffield	Observational	Not yet recruiting	MND (Motor Neurone DIsease)	287	United Kingdom	clinicaltrials.gov
February 2, 2026	NCT07380204	Quantification of Hsp90 in the Human Brain	Universitaire Ziekenhuizen KU Leuven	Not applicable	Recruiting	Parkinson's Disease (PD), Alzheimer's Disease (AD), Amyotrophic Lateral Sclerosis (ALS)	48	Belgium	clinicaltrials.gov
January 27, 2026	NCT07369076	A Clinical Trial to Evaluate NB-4746 in Participants With Amyotrophic Lateral Sclerosis.	Nura Bio	Phase 1/2	Recruiting	Amyotrophic Lateral Sclerosis (ALS)	80	Australia, Canada, Netherlands, Poland	clinicaltrials.gov
January 22, 2026	NCT07357428	Connect-One: Early Feasibility Study of Connexus® Brain-Computer Interface (BCI)	Paradromics	Not applicable	Recruiting	Amyotrophic Lateral Sclerosis, Neuromuscular Disease, Stroke, Tetraplegia/Tetraparesis, Cervical Spinal Cord Injury...	2	United States	clinicaltrials.gov
January 15, 2026	NCT07341984	A Physiotherapy Intervention Study in Patients With Amyotrophic Lateral Sclerosis (ALS)	Charlotte Vogt	Not applicable	Recruiting	Amyotrophic Lateral Sclerosis	38	Switzerland	clinicaltrials.gov
January 14, 2026	NCT07341334	Digital Speech Markers for Monitoring ALS in Spanish Speakers	Nova Southeastern University	Observational	Not yet recruiting	Amyotrophic Lateral Sclerosis, Lou Gehrig's Disease, ALS	35	United States	clinicaltrials.gov
January 12, 2026	NCT07334743	Identifying Biomarkers in ALS Patients Using Neuronal Derived Extracellular Vesicles	Fondation Ophtalmologique Adolphe de Rothschild	Observational	Recruiting	Amyotrophic Lateral Sclerosis, ENGRAILED1	60	France	clinicaltrials.gov
January 8, 2026	NCT07325591	Efficacy and Safety of Tazbentetol in ALS Participants	Spinogenix	Phase 2/3	Not yet recruiting	Amyotrophic Lateral Sclerosis	430		clinicaltrials.gov
January 7, 2026	NCT07322003	Pridopidine Phase 3 Study to Evaluate Efficacy and Safety in ALS	Prilenia	Phase 3	Recruiting	Amyotrophic Lateral Sclerosis	500	Belgium, Canada, France, Germany, Ireland, Israel, Italy, Netherlands, Poland...	clinicaltrials.gov
January 7, 2026	NCT07321860	This Study Evaluates the Safety, Target Engagement, and Preliminary Efficacy of Galunisertib (TGF-βR1/ALK5 Inhibitor)Combined With...	Gipfel Life Sciences GmbH	Phase 2/3	Not yet recruiting	ALS (Amyotrophic Lateral Sclerosis)	60		clinicaltrials.gov
December 31, 2025	NCT07312240	LONgitudinal and Integrated Evaluation of Biomarkers in reLation to phenotYpe in ALS	Istituto Auxologico Italiano	Not applicable	Recruiting	Amyotrophic Lateral Sclerosis	140	Italy	clinicaltrials.gov
December 24, 2025	NCT07302321	Needs of ALS Patients With C9orf72 Mutation and Their Caregivers	Istituto Auxologico Italiano	Observational	Recruiting	Amyotrophic Lateral Sclerosis	208	Italy	clinicaltrials.gov
December 23, 2025	NCT07298486	Impact of Robotic Glove Use on Quality of Life, Grip Strength and Fine Motor Control in ALS	Nova Southeastern University	Not applicable	Enrolling by invitation	Amyotrophic Lateral Sclerosis (ALS)	5	United States	clinicaltrials.gov
December 22, 2025	NCT07295990	Tongue-strengthening Exercises in People With ALS.	Nova Southeastern University	Not applicable	Recruiting	ALS (Amyotrophic Lateral Sclerosis), ALS - Amyotrophic Lateral Sclerosis	20	United States	clinicaltrials.gov
December 19, 2025	NCT07294144	Tofersen in Non-SOD1 ALS	Washington University School of Medicine	Phase 2	Recruiting	ALS (Amyotrophic Lateral Sclerosis)	30	United States	clinicaltrials.gov
December 18, 2025	NCT07292545	Video-Based Proprioceptive Exercise Program in ALS	Tarsus University	Not applicable	Recruiting	Amyotrophic Lateral Sclerosis	20	Turkey (Türkiye)	clinicaltrials.gov
December 17, 2025	NCT07290062	A Study to Investigate the Safety and Pharmacodynamics of a Single Intrathecal Injection (IT) of INS1202 in Participants With Amyotrophic...	Insmed Gene Therapy LLC	Phase 1	Recruiting	Amyotrophic Lateral Sclerosis	23	United States	clinicaltrials.gov
December 17, 2025	NCT07287397	Study is to Assess the Safety and Tolerability of VTx-002 in Participants With ALS	Vector Y Therapeutics	Phase 1/2	Recruiting	Amyotrophic Lateral Sclerosis	36	Belgium, Netherlands, United Kingdom, United States	clinicaltrials.gov
December 8, 2025	NCT07268833	Translating Single-cell Vulnerability Into Novel ALS Biomarkers and Therapeutic Targets: Towards a Liquid Nerve Biopsy	Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta	Observational	Recruiting	Amyotrophic Lateral Sclerosis (ALS), Peripheral Neuropathies	400	Italy	clinicaltrials.gov
December 3, 2025	NCT07260981	Comprehensive Biomarker Profiling of the IFN-α Pathway in Amyotrophic Lateral Sclerosis Patient Biofluids	Ulysses Neuroscience LTD	Observational	Completed	ALS - Amyotrophic Lateral Sclerosis	60	Ireland	clinicaltrials.gov
December 2, 2025	NCT07259980	A Study to Learn More About the Long-Term Safety of Tofersen (Qalsody) in Participants With Superoxide Dismutase 1 (SOD-1) Amyotrophic...	Biogen	Observational	Recruiting	Amyotrophic Lateral Sclerosis	125	United States	clinicaltrials.gov
December 2, 2025	NCT07257302	Lung Insufflation Capacity Training and Respiratory Function in Amyotrophic Lateral Sclerosis	National Center of Neurology and Psychiatry, Japan	Not applicable	Recruiting	Amyotrophic Lateral Sclerosis (ALS)	25	Japan	clinicaltrials.gov
November 19, 2025	NCT07235111	Omics Sciences for the Identification of Pathogenetic Mechanisms and Biomarkers in Neurodegenerative Diseases	Ospedale Policlinico San Martino	Observational	Recruiting	Alzheimer Disease, FTD, Young-onset Dementia, MCI, Parkinson Disease, ALS (Amyotrophic Lateral Sclerosis)	1,200	Italy	clinicaltrials.gov
November 18, 2025	NCT07233148	Healing ALS Registry Observational Study (HAROS)	Healing Advocates Registry and Ministry	Observational	Recruiting	Amyotrophic Lateral Sclerosis (ALS), Motor Neuron Disease (MND), Primary Lateral Sclerosis (PLS)	1,000	United States	clinicaltrials.gov
November 4, 2025	NCT07224269	Effect of Terazosin on ATP Levels in People With Amyotrophic Lateral Sclerosis	University of Iowa	Early phase 1	Recruiting	Amyotrophic Lateral Sclerosis, Adenosine Triphosphate Activities	20	United States	clinicaltrials.gov
November 4, 2025	NCT07224256	VOICE: An Early Feasibility Study of a Precise Robotically Implanted Brain-Computer Interface for Communication Restoration	Neuralink Corp	Not applicable	Recruiting	Tetraplegia/Tetraparesis, Quadriplegia, Cervical Spinal Cord Injury, Amyotrophic Lateral Sclerosis...	6	United States	clinicaltrials.gov
November 3, 2025	NCT07223723	A Study to Learn More About the Long-Term Safety of Tofersen (Qalsody) in Chinese Participants With SOD-1 Amyotrophic Lateral Sclerosis...	Biogen	Phase 4	Active not recruiting	Amyotrophic Lateral Sclerosis	12	China	clinicaltrials.gov
October 27, 2025	NCT07221240	Study to Evaluate Safety, Tolerability, and Pharmacokinetics of Amisodin in Healthy Adult Subjects With Amyotrophic Lateral Sclerosis	PRG Science & Technology Co., Ltd.	Phase 1	Recruiting	Amyotrophic Lateral Sclerosis	48	United States	clinicaltrials.gov
October 8, 2025	NCT07213440	Identification of Early Markers for ALS	Institut National de la Santé Et de la Recherche Médicale, France	Not applicable	Recruiting	Amyotrophic Lateral Sclerosis (ALS)	60	France	clinicaltrials.gov
October 7, 2025	NCT07209943	Augmented Reality BCI Longitudinal Study for Persons With ALS, Stroke, TBI and SCI Utilizing Cognixion + Apple Vision Pro	Cognixion	Not applicable	Not yet recruiting	ALS (Amyotrophic Lateral Sclerosis), TBI Traumatic Brain Injury, SCI - Spinal Cord Injury, Stroke	10	United States	clinicaltrials.gov
October 3, 2025	NCT07204977	Acamprosate in C9orf72 Hexanucleotide Repeat Expansion Amyotrophic Lateral Sclerosis (ACALS)	National Institute of Neurological Disorders and Stroke (NINDS)	Phase 1	Recruiting	Amyotrophic Lateral Sclerosis, Motor Neuron Disease	30	United States	clinicaltrials.gov
October 1, 2025	NCT07202494	Integrating Metabolism, Connectivity, and Mesoscale Imaging at Ultra-high Field to Decipher Mechanisms of Resilience and Neurodegeneration...	Assistance Publique Hopitaux De Marseille	Observational	Recruiting	Multiple Sclerosis, Neuromyelitis Optica Spectrum Disorders, Myelin Oligodendrocyte Glycoprotein Antibody-Associated...	700	France	clinicaltrials.gov
September 26, 2025	NCT07193953	Intravenous Immunoglobulin (IVIG) and Blood-Brain Barrier Disruption in Amyotrophic Lateral Sclerosis (ALS)	Sunnybrook Health Sciences Centre	Phase 1	Active not recruiting	Amyotrophic Lateral Sclerosis, ALS	6	Canada	clinicaltrials.gov
September 23, 2025	NCT07187388	Investigating the Impact of Electrical Stimulation on Facial Pain, Jaw Movement and Oral Health in People With Motor Neuron Disease.	Nova Southeastern University	Not applicable	Recruiting	Amyotrophic Lateral Sclerosis (ALS), Primary Lateral Sclerosis (PLS), Motor Neuron Disease, Amyotrophic Lateral...	10	United States	clinicaltrials.gov
September 17, 2025	NCT07178574	Polish Version Dyspnea in Amyotrophic Lateral Sclerosis	Jakub Antczak	Observational	Not yet recruiting	Amyotrophic Lateral Sclerosis	120		clinicaltrials.gov

Sponsors posting most

Sponsor	New trials	Latest
n-Lorem Foundation	6	August 3, 2026
Nova Southeastern University	5	May 26, 2026
Neuralink Corp	5	November 4, 2025
Eli Lilly and Company	4	October 20, 2026
Cognixion	3	October 13, 2026
Biogen	3	October 2, 2026
Assistance Publique - Hôpitaux de Paris	3	May 6, 2026
Massachusetts General Hospital	3	February 10, 2026
Spinogenix	3	January 8, 2026
Beijing Tiantan Hospital	3	July 23, 2025
Liu Qing	2	November 6, 2026
University of Utah	2	September 23, 2026
Johns Hopkins University	2	September 16, 2026
Copenhagen University Hospital, Rigshospitalet	2	September 15, 2026
University of Pennsylvania	2	September 1, 2026
IRCCS San Raffaele	2	September 1, 2026
University Hospital, Montpellier	2	July 30, 2026
University Hospital, Grenoble	2	July 13, 2026
Duke University	2	May 15, 2026
Synchron, Inc.	2	April 21, 2026

By phase

Phase	New trials	Latest
Not applicable	56	November 6, 2026
Observational	44	October 28, 2026
Phase 1	20	October 30, 2026
Phase 1/2	17	October 2, 2026
Phase 2	15	September 22, 2026
Early phase 1	8	November 4, 2025
Phase 2/3	6	February 13, 2026
Phase 3	3	January 7, 2026
Phase 4	2	November 3, 2025

By country

Country	New trials	Latest
United States	63	October 30, 2026
Italy	20	October 8, 2026
China	14	September 22, 2026
France	12	July 30, 2026
Netherlands	12	June 29, 2026
Germany	10	October 28, 2026
Canada	10	October 20, 2026
United Kingdom	10	October 1, 2026
Spain	9	July 30, 2026
Belgium	9	May 19, 2026
Australia	6	April 16, 2026
Poland	6	January 27, 2026
Ireland	4	January 7, 2026
Sweden	3	June 22, 2026
Denmark	2	March 12, 2026
Japan	2	December 2, 2025
Thailand	2	September 16, 2025
Czechia	2	August 26, 2025
Taiwan	1	July 24, 2026
Switzerland	1	January 15, 2026
Israel	1	January 7, 2026
Turkey (Türkiye)	1	December 18, 2025
Romania	1	September 17, 2025
Greece	1	September 16, 2025
Serbia	1	August 26, 2025

Where the register publishes

U.S. government data; ClinicalTrials.gov terms of use. Studies are as their sponsors registered them on ClinicalTrials.gov, read through its API. Condition groups are the MeSH terms ClinicalTrials.gov assigns to each study's conditions; a study with several is in several groups. Sponsor class is the register's class of the lead sponsor. The central contact is in the full list only as the record prints it. Free to reuse with credit to SpecStream under CC BY 4.0. Spot a wrong value? Write to [email protected] with the link to this page.