| Meeting Street Schools | 501(c)(3) | 2007 | $46.8 million | $311.8 million | 2025-06 |
| Citadel Foundation | 501(c)(3) | 1964 | $37.9 million | $332.3 million | 2024-12 |
| Ashley Hall Foundation | 501(c)(3) | 1950 | $31.5 million | $71.6 million | 2025-06 |
| James Island Charter High School | 501(c)(3) | 2005 | $27.6 million | $18.9 million | 2025-06 |
| Charleston School of Law | 501(c)(3) | 2004 | $27.1 million | $41.4 million | 2024-12 |
| Berkeley Charter Education Association Inc | 501(c)(3) | 2017 | $24.4 million | $31.2 million | 2025-06 |
| College of Charleston Foundation | 501(c)(3) | 1971 | $23.2 million | $222.6 million | 2025-06 |
| Orange Grove Elementary Charter School | 501(c)(3) | 2009 | $18.7 million | $25.6 million | 2025-06 |
| Charleston Charter School for Math and Science | 501(c)(3) | 2009 | $10.7 million | $4.2 million | 2025-06 |
| Charleston Day School Inc | 501(c)(3) | 1972 | $8.4 million | $31.1 million | 2025-06 |
| Citadel Real Estate Foundation | 501(c)(3) | 2016 | $7.2 million | $33.2 million | 2024-12 |
| Carolina Voyager Charter School | 501(c)(3) | 2014 | $7.1 million | $27.8 million | 2025-06 |
| Citadel Brigadier Foundation Inc | 501(c)(3) | 1959 | $6.7 million | $38.5 million | 2024-12 |
| Mason Preparatory School | 501(c)(3) | 1965 | $6.7 million | $17 million | 2025-05 |
| Addlestone Hebrew Academy | 501(c)(3) | 2003 | $6.3 million | $2.7 million | 2025-06 |
| American College of the Building Arts | 501(c)(3) | 1999 | $4.8 million | $13.6 million | 2025-07 |
| Pattisons D R E A M Academy | 501(c)(3) | 2006 | $4.5 million | $1.1 million | 2025-06 |
| Cooper School | 501(c)(3) | 2007 | $3.7 million | $4.9 million | 2025-06 |
| Charleston Development Acdemy | 501(c)(3) | 2005 | $2.7 million | $1.5 million | 2025-06 |
| Trident Technical College Foundation Incorporated | 501(c)(3) | 1981 | $2.5 million | $23.6 million | 2025-06 |
| The Citadel Alumni Association | 501(c)(3) | 1979 | $1.8 million | $12.9 million | 2024-12 |
| Heritage Community Services Inc | 501(c)(3) | 1998 | $1.5 million | $583,293 | 2024-12 |
| Marine Science and Nauticaltraining Academy | 501(c)(3) | 2007 | $1.5 million | $2.1 million | 2024-12 |
| Trinity Montessori Christian School Inc | 501(c)(3) | 2014 | $1.3 million | $1.4 million | 2025-07 |
| Charleston Promise Neighborhood | 501(c)(3) | 2011 | $1.2 million | $1.8 million | 2025-06 |
| Engaging Creative Minds | 501(c)(3) | 2014 | $1.1 million | $218,035 | 2025-08 |
| College of Charleston Alumni Association Inc | 501(c)(3) | 1968 | $916,393 | $653,752 | 2025-06 |
| South Carolina Association of Public Charter Schools Inc | 501(c)(3) | 2007 | $813,947 | $1 million | 2025-06 |
| Saint James Day School Inc | 501(c)(3) | 2013 | $582,508 | $230,488 | 2025-12 |
| Association of Cancer Executives | 501(c)(3) | 1996 | $506,725 | $350,173 | 2025-06 |
| Charleston Hope | 501(c)(3) | 2014 | $501,344 | $265,147 | 2025-06 |
| Friends of the Charleston County Library | 501(c)(3) | 1984 | $380,695 | $410,444 | 2024-12 |
| Sior Se Regional Convention Inc | 501(c)(3) | 2020 | $313,262 | $527,275 | 2025-12 |
| Lowcountry Maritime Society | 501(c)(3) | 2011 | $299,340 | $37,764 | 2025-06 |
| Government Finance Officers Association of Pennsylvania | 501(c)(3) | 2005 | $280,277 | $462,900 | 2024-12 |
| Community College Business Officers | 501(c)(6) | 2005 | $245,306 | $271,637 | 2024-12 |
| Adoption Options Inc | 501(c)(3) | 1997 | $210,716 | $34,839 | 2025-12 |
| E3 Educate-Empower-Elevate | 501(c)(3) | 2022 | $206,364 | $14,755 | 2024-12 |
| South Carolina Society of Anesthesiologists | 501(c)(6) | 2026 | $172,943 | $351,391 | 2020-12 |
| Orange Grove Elementary Charter School Pto | 501(c)(3) | 2015 | $160,173 | $84,741 | 2025-07 |
| Northeast Region Burn Conference Planning Organization | 501(c)(3) | 2017 | $150,398 | $55,926 | 2025-12 |
| James Island High School Booster Club Inc | 501(c)(3) | 2014 | $129,707 | $52,889 | 2024-12 |
| Veterans On Deck | 501(c)(3) | 2011 | $109,827 | $28,912 | 2026-06 |
| Charleston Ocean Racing Association Inc | 501(c)(3) | 2014 | $107,812 | $331,896 | 2025-12 |
| Green and Healthy Inc | 501(c)(3) | 2020 | $106,872 | $380,083 | 2025-06 |
| Triple B Club for Bishop England High | 501(c)(3) | 2002 | $105,873 | $189,335 | 2025-05 |
| Carolinas Payroll Conference | 501(c)(3) | 2009 | $103,947 | $65,265 | 2025-12 |
| Buist Academy Foundation | 501(c)(3) | 2002 | $101,683 | $491,038 | 2025-06 |
| Experiencecharleston Org Inc | 501(c)(3) | 2018 | $100,032 | $5,817 | 2025-12 |
| Springfield Elementary School Pta | 501(c)(3) | 2025 | $67,776 | $18,207 | 2026-06 |
| Team Nelson Inc | 501(c)(3) | 2018 | $67,430 | $100,816 | 2025-12 |
| Emergency Nurses Association | 501(c)(3) | 2003 | $67,418 | $164,106 | 2025-12 |
| Parent Booster USA Inc | 501(c)(3) | 2005 | $56,683 | $13,827 | 2025-06 |
| Amazing Maasai Girls Project | 501(c)(3) | 2011 | $56,418 | $756,387 | 2025-12 |
| Memminger School of Global Studies | 501(c)(3) | 2022 | $55,148 | $8,239 | 2026-02 |
| Philip Simmons High School Band Booster | 501(c)(3) | 2019 | $54,713 | $92,936 | 2026-06 |
| Toadfish Outfitters Conservation Coalition Inc | 501(c)(3) | 2020 | $53,795 | $45,634 | 2024-12 |
| Knights Parent Guild | 501(c)(3) | 1997 | $44,309 | $85,333 | 2025-06 |
| German Friendly Society Foundation | 501(c)(3) | 2012 | $37,907 | $482,425 | 2025-12 |
| Oakland Elementary Pto | 501(c)(3) | 2021 | $30,372 | $20,144 | 2025-06 |
| Country Club of Charleston Employee Assistance Fund Incorporated | 501(c)(3) | 2020 | $28,810 | $224,508 | 2025-12 |
| Charleston Area Model Railroad Club Inc | 501(c)(3) | 2016 | $24,005 | $130,584 | 2025-12 |
| Burke High School Foundation | 501(c)(3) | 2015 | $22,750 | $47,916 | 2024-12 |
| Charleston Day School Parentscouncil | 501(c)(3) | 2006 | $21,594 | $21,273 | 2025-07 |
| State Child Care Administrators Network | 501(c)(3) | 2016 | $21,000 | $77,165 | 2025-12 |
| The Harry and Reba Huge Foundation | 501(c)(3) | 2006 | $16,902 | $435,107 | 2024-12 |
| First Baptist School Foundation | 501(c)(3) | 2012 | $13,882 | $783,766 | 2025-05 |
| Ace Mentory Program of Greater Charleston Inc | 501(c)(3) | 2014 | $13,004 | $11,423 | 2025-06 |
| Charleston Women in Tech | 501(c)(3) | 2016 | $7,481 | $52,771 | 2024-12 |
| 1913 the Death of Us Inc | 501(c)(3) | 2025 | | | |
| A Home for School | 501(c)(3) | 2023 | $0 | $0 | 2024-12 |
| Abundant Life Christian Academy of Charleston Inc | 501(c)(3) | 1998 | | | |
| Alumni Association of the Medical University of South Caroli | 501(c)(3) | 2026 | | | |
| American Student Dental Association | 501(c)(6) | 1971 | $0 | $0 | 2025-12 |
| Autistic Life Inc | 501(c)(3) | 2022 | | $7,048 | 2025-12 |
| Bahari Ministry | 501(c)(3) | 2025 | | | |
| Barrier Islands Educationalfoundation Inc | 501(c)(3) | 2014 | $0 | $0 | 2025-12 |
| Beemok Family Foundation | 501(c)(3) | 2014 | | $42.5 million | 2024-12 |
| Benjamin Wyatt Burris Foundation Inc | 501(c)(3) | 2010 | $0 | $0 | 2024-12 |
| Berkeley Charter Education Foundati On | 501(c)(3) | 2026 | | | |
| Beta Kappa Lambda Chapter of Alpha Phi Alpha Fraternity | 501(c)(3) | 2014 | $0 | $0 | 2025-12 |
| Book Angels Charleston Inc | 501(c)(3) | 2017 | $0 | $0 | 2023-12 |
| CCSMS Parent Teacher Organization Inc | 501(c)(3) | 2009 | $0 | $0 | 2024-06 |
| CHS Development Company | 501(c)(3) | 2014 | $0 | $370,565 | 2025-06 |
| Camp Road Band Boosters | 501(c)(3) | 2025 | $0 | $0 | 2026-06 |
| Camp Road Middle School Athletic Booster Club | 501(c)(3) | 2008 | $0 | $0 | 2026-04 |
| Camp Road Middle School Pto | 501(c)(3) | 2017 | $0 | $0 | 2026-06 |
| Career-Ready Coalition Inc | 501(c)(3) | 2018 | | $289 | 2024-12 |
| Carolina Voyager Charter School Parent Teacher Organization | 501(c)(3) | 2016 | $0 | $0 | 2025-12 |
| Charleston Christian School | 501(c)(3) | 2025 | | | |
| Charleston Coalition for Kids | 501(c)(4) | 2019 | $0 | $25,862 | 2025-06 |
| Charleston Jung Society Inc | 501(c)(3) | 2018 | $0 | $0 | 2025-12 |
| Charleston Planetarium Society | 501(c)(3) | 2023 | $0 | $0 | 2025-12 |
| Christine L Goss Foundation | 501(c)(3) | 2024 | | | |
| College of Charleston Womens Rugby Football Club Alumni Association | 501(c)(3) | 2023 | $0 | $0 | 2025-12 |
| Cristo Rey Charleston High School Corporate Work Study Program Inc | 501(c)(3) | 2025 | | | |
| Csta | 501(c)(3) | 2020 | $0 | $0 | 2025-06 |
| Dartmouth Club of the Lowcountry Inc | 501(c)(3) | 2022 | $0 | $0 | 2026-06 |
| Drayton Hall Elementary Pto | 501(c)(3) | 2026 | | | |
| Dream Makers Education Foundation | 501(c)(3) | 2014 | $0 | $0 | 2025-12 |
| Edgewater Educational and Nutritional Systems Incorporated | 501(c)(3) | 2025 | | | |
| Education Engine Inc | 501(c)(3) | 2026 | | | |
| Epitome of Epilepsy | 501(c)(3) | 2025 | | $14,740 | 2025-12 |
| Faith Dutton Yellow Shoes Foundation | 501(c)(3) | 2021 | $0 | $0 | 2025-06 |
| First Baptist School | 501(c)(3) | 2010 | | | |
| Friends Of@james Simons Elementary | 501(c)(3) | 2017 | $0 | $0 | 2024-12 |
| Gamma Lambda Boule Foundation | 501(c)(3) | 2019 | $0 | $0 | 2024-12 |
| Goff Foundation | 501(c)(3) | 2026 | | | |
| Griffin Weathers Foundation | 501(c)(3) | 2018 | | $1 | 2023-12 |
| Gullah Geechee Group Inc | 501(c)(3) | 2010 | $0 | $0 | 2025-12 |
| Health and Wellness Mission Trust | 501(c)(3) | 2026 | $0 | $0 | 2025-12 |
| Highlands Latin School Charleston | 501(c)(3) | 2023 | $0 | $39,955 | 2025-06 |
| Honor Society of Phi Kappa Phi | 501(c)(3) | 1999 | $0 | $0 | 2026-06 |
| Hope Group | 501(c)(3) | 2024 | $0 | $0 | 2025-12 |
| Hurricane Scholarship Foundation Inc | 501(c)(3) | 2025 | | | |
| Iguana Innovative Languages | 501(c)(3) | 2020 | $0 | $5 | 2023-12 |
| James Island Christian School | 501(c)(3) | 1998 | | | |
| Johannes Kepler Project | 501(c)(3) | 2007 | $0 | $0 | 2025-12 |
| Kappa Psi Pharmaceutical Fraternity Inc | 501(c)(7) | 1964 | $0 | $0 | 2025-12 |
| Legacy Traditional Schools - North Carolina | 501(c)(3) | 2025 | | | |
| Literacy in the Disciplines 6-12 | 501(c)(3) | 2021 | $0 | $0 | 2026-06 |
| Lowcountry Center for Academic Equity | 501(c)(3) | 2022 | $0 | $0 | 2025-12 |
| Lowcountry Legacy Fund | 501(c)(3) | 2025 | | | |
| Millenium Inspiration Religious Education Association | 501(c)(3) | 2025 | | | |
| Murray Lasaine Pto | 501(c)(3) | 2017 | $0 | $0 | 2025-06 |
| Palmetto Tomorrow Foundation | 501(c)(3) | 2006 | $0 | $0 | 2023-12 |
| Porter-Gaud School | 501(c)(3) | 2006 | | | |
| Reforge Charleston | 501(c)(3) | 2016 | $0 | $0 | 2025-12 |
| Roddy White Keep the Faith Foundation | 501(c)(3) | 2011 | $0 | $0 | 2025-12 |
| Rotor | 501(c)(3) | 2023 | $0 | $0 | 2025-12 |
| Roy and Amanda Maybank Charitable Foundation | 501(c)(3) | 2014 | | $79,997 | 2024-12 |
| Salt Marsh Kids | 501(c)(3) | 2023 | $0 | $0 | 2025-12 |
| South Carolina Association of Treatment Court Professionals | 501(c)(3) | 2024 | $0 | $0 | 2026-06 |
| South Carolina City and County Management Scholarship Foundation | 501(c)(3) | 2012 | $0 | $0 | 2025-06 |
| South Carolina Marine Educators Association | 501(c)(3) | 2014 | $0 | $0 | 2025-12 |
| South Carolina State University National Alumni Association | 501(c)(3) | 2001 | $0 | $0 | 2025-05 |
| Southern Clemente Community Alliance | 501(c)(3) | 2019 | $0 | $0 | 2025-06 |
| St Joan of Arc Hybrid Inc | 501(c)(3) | 2025 | | | |
| Tau Eta Alumni Education Foundation | 501(c)(3) | 2024 | $0 | $0 | 2025-12 |
| Teach Charleston | 501(c)(3) | 2019 | $0 | $0 | 2025-12 |
| The Sea of Stars Foundation | 501(c)(3) | 2014 | | $261,099 | 2025-12 |
| Theta Commission Foundation | 501(c)(3) | 2017 | $0 | $0 | 2025-12 |
| Tori Tutoring | 501(c)(3) | 2024 | $0 | $0 | 2024-12 |
| Tywanza Sanders Legacy Foundation | 501(c)(3) | 2017 | $0 | $0 | 2025-12 |
| Wando High Mse Booster Fund Inc | 501(c)(3) | 2009 | $0 | $0 | 2025-12 |
| West Ashley High School Parent Teacher Student Organization | 501(c)(3) | 2019 | $0 | $0 | 2023-07 |
| Zeta Gamma of Chi Omega Fraternity House Corporation | 501(c)(4) | 2015 | $0 | $0 | 2025-12 |
| Zeta Phi Beta Sorority Inc Chi Iota Chapter | 501(c)(4) | 2022 | $0 | $0 | 2026-06 |
| Humanities Housing Inc | 501(c)(3) | 2001 | $-300,000 | $130,925 | 2024-12 |