Data / Nonprofits / South Carolina / Charleston
Nonprofits in Charleston, SC: 1,343 registered with the IRS
1,343 nonprofits are registered with the IRS in Charleston, SC, 1,154 of them 501(c)(3) charities; the 496 that report revenue took in $2.70 billion. The largest by revenue: Bon Secours-St Francis Xavier Hospital Inc ($620.6 million), Roper Hospital Inc ($539.5 million), The Medical University of South Carolina Foundation ($136.7 million). Most common causes: education (149), religion-related (104), arts, culture and humanities (101).
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The 500 largest by revenue
| Organization | Category | Type | Since | Revenue | Assets | Filing |
|---|---|---|---|---|---|---|
| Bon Secours-St Francis Xavier Hospital Inc | Health care | 501(c)(3) | 1998 | $620.6 million | $319 million | 2024-12 |
| Roper Hospital Inc | Health care | 501(c)(3) | 1955 | $539.5 million | $343.1 million | 2024-12 |
| The Medical University of South Carolina Foundation | Medical research | 501(c)(3) | 2024 | $136.7 million | $944.2 million | 2025-06 |
| Lowcountry Food Bank Inc | 501(c)(3) | 1984 | $90.1 million | $35.1 million | 2024-12 | |
| Bishop Gadsden Episcopal Retirement Community | Human services | 501(c)(3) | 1943 | $83.5 million | $387.5 million | 2025-12 |
| Musc Affiliate Physicians | Mental health and crisis intervention | 501(c)(3) | 2023 | $82.1 million | $31.8 million | 2025-06 |
| Palmetto Goodwill | Human services | 501(c)(3) | 2015 | $65.1 million | $137.2 million | 2024-12 |
| Charleston Educational Excellence Financing Corporation | Recreation and sports | 501(c)(3) | 2006 | $57.3 million | $326.1 million | 2025-06 |
| We Are Sharing Hope SC | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 2006 | $52.3 million | $60.5 million | 2025-12 |
| Musc Health Partners | Health care | 501(c)(3) | 2020 | $49.4 million | $9.1 million | 2025-06 |
| Meeting Street Schools | Education | 501(c)(3) | 2007 | $46.8 million | $311.8 million | 2025-06 |
| Container Royalties Supplemental | 501(c)(5) | 2014 | $38.2 million | $24.5 million | 2025-09 | |
| Citadel Foundation | Education | 501(c)(3) | 1964 | $37.9 million | $332.3 million | 2024-12 |
| Ashley Hall Foundation | Education | 501(c)(3) | 1950 | $31.5 million | $71.6 million | 2025-06 |
| James Island Charter High School | Education | 501(c)(3) | 2005 | $27.6 million | $18.9 million | 2025-06 |
| Charleston School of Law | Education | 501(c)(3) | 2004 | $27.1 million | $41.4 million | 2024-12 |
| Musc Health | Health care | 501(c)(3) | 2017 | $24.6 million | $119.9 million | 2025-06 |
| Berkeley Charter Education Association Inc | Education | 501(c)(3) | 2017 | $24.4 million | $31.2 million | 2025-06 |
| Fetter Health Care Network Inc | 501(c)(3) | 1976 | $23.9 million | $14.3 million | 2025-03 | |
| College of Charleston Foundation | Education | 501(c)(3) | 1971 | $23.2 million | $222.6 million | 2025-06 |
| Charleston Area Convention & Visitors Bureau | Community improvement and capacity building | 501(c)(6) | 2002 | $22.9 million | $19.6 million | 2025-06 |
| South Carolina Aquarium | Animal-related | 501(c)(3) | 1993 | $20.3 million | $50.9 million | 2024-12 |
| Waterfront Employers I L A Welfare Fund | 501(c)(9) | 1970 | $19.7 million | $13.5 million | 2025-09 | |
| Palmetto Goodwill Services | Employment | 501(c)(3) | 1945 | $18.8 million | $21.3 million | 2024-12 |
| Orange Grove Elementary Charter School | Education | 501(c)(3) | 2009 | $18.7 million | $25.6 million | 2025-06 |
| One-Eighty Place | Housing and shelter | 501(c)(3) | 1985 | $18.2 million | $24.7 million | 2025-06 |
| Medical Society of S C | Health care | 501(c)(3) | 1979 | $17.7 million | $701.6 million | 2024-12 |
| Mainsail Health Partners | Health care | 501(c)(3) | 2020 | $15.1 million | $207.1 million | 2025-06 |
| Guthrie Risk Retention Group | Mental health and crisis intervention | 501(c)(3) | 2006 | $13.8 million | $53.9 million | 2024-12 |
| Country Club of Charleston | 501(c)(7) | 1946 | $12.8 million | $26.3 million | 2025-04 | |
| Lowcountry Land Trust Inc | Environment | 501(c)(3) | 1986 | $12.6 million | $39.3 million | 2025-06 |
| Charleston Gaillard Management Corporation | Arts, culture and humanities | 501(c)(3) | 2014 | $12.4 million | $9.9 million | 2025-06 |
| Ronald McDonald House Charleston | Health care | 501(c)(3) | 1982 | $12.1 million | $33.4 million | 2025-12 |
| Charleston County Human Services Commission | Human services | 501(c)(3) | 1986 | $11.6 million | $6.5 million | 2024-12 |
| Spoleto Festival U S A | Arts, culture and humanities | 501(c)(3) | 1978 | $11.3 million | $21.4 million | 2025-08 |
| International African American Museum | Arts, culture and humanities | 501(c)(3) | 2007 | $11.2 million | $73.5 million | 2024-12 |
| Charleston Charter School for Math and Science | Education | 501(c)(3) | 2009 | $10.7 million | $4.2 million | 2025-06 |
| College of Charleston Athletic Club | Recreation and sports | 501(c)(3) | 1977 | $9.9 million | $7 million | 2025-06 |
| South Carolina Coastal Conservation League Inc | Environment | 501(c)(3) | 1989 | $9.6 million | $22 million | 2025-06 |
| Charleston Day School Inc | Education | 501(c)(3) | 1972 | $8.4 million | $31.1 million | 2025-06 |
| Southeast Coastal Ocean Observing Regional Association | Community improvement and capacity building | 501(c)(3) | 2008 | $7.4 million | $3.4 million | 2025-06 |
| Oneworld Health | International, foreign affairs and national security | 501(c)(3) | 2009 | $7.3 million | $7.2 million | 2025-06 |
| Citadel Real Estate Foundation | Education | 501(c)(3) | 2016 | $7.2 million | $33.2 million | 2024-12 |
| Carolina Voyager Charter School | Education | 501(c)(3) | 2014 | $7.1 million | $27.8 million | 2025-06 |
| South Carolina Community Loan Fund | Housing and shelter | 501(c)(3) | 2004 | $6.9 million | $49.6 million | 2024-12 |
| Citadel Brigadier Foundation Inc | Education | 501(c)(3) | 1959 | $6.7 million | $38.5 million | 2024-12 |
| Mason Preparatory School | Education | 501(c)(3) | 1965 | $6.7 million | $17 million | 2025-05 |
| Addlestone Hebrew Academy | Education | 501(c)(3) | 2003 | $6.3 million | $2.7 million | 2025-06 |
| Carolina Art Association | Arts, culture and humanities | 501(c)(3) | 1955 | $6 million | $23.5 million | 2025-06 |
| Charleston Symphony Orchestra | Arts, culture and humanities | 501(c)(3) | 1946 | $5.8 million | $11.3 million | 2025-06 |
| Musc Foundation for Research Development | Medical research | 501(c)(3) | 1997 | $5.6 million | $4.7 million | 2025-06 |
| Lowcountry Center for Veterans Research | Medical research | 501(c)(3) | 2000 | $5.4 million | $6 million | 2025-09 |
| The Dee Norton Lowcountry Childrens Center Inc | 501(c)(3) | 1990 | $5.2 million | $14.3 million | 2026-03 | |
| Southeastern Wildlife Exposition Inc | Environment | 501(c)(3) | 2003 | $5.1 million | $6.1 million | 2025-06 |
| Historic Charleston Foundation | 501(c)(3) | 1949 | $4.8 million | $34.7 million | 2024-12 | |
| American College of the Building Arts | Education | 501(c)(3) | 1999 | $4.8 million | $13.6 million | 2025-07 |
| Uncommon Charitable Impact Inc | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 2021 | $4.7 million | $6.5 million | 2025-12 |
| STC Healthcare Partners Risk Retention Group | Health care | 501(c)(3) | 2022 | $4.7 million | $24 million | 2025-12 |
| Charleston Wine & Food Festival | Food, agriculture and nutrition | 501(c)(3) | 2006 | $4.5 million | $384,898 | 2025-06 |
| Pattisons D R E A M Academy | Education | 501(c)(3) | 2006 | $4.5 million | $1.1 million | 2025-06 |
| Charleston Regional Development Alliance | 501(c)(6) | 1996 | $4.3 million | $3.6 million | 2025-06 | |
| South Carolina Infant Young Child Mental Health Association | Mental health and crisis intervention | 501(c)(3) | 2018 | $4.1 million | $2.2 million | 2025-06 |
| Preservation Society of Charleston | 501(c)(3) | 1961 | $4 million | $13.1 million | 2025-06 | |
| Wings for Kids | Human services | 501(c)(3) | 1996 | $4 million | $3 million | 2025-06 |
| Charleston Museum | Arts, culture and humanities | 501(c)(3) | 1950 | $3.8 million | $24.5 million | 2024-12 |
| Charleston Stage Company | Arts, culture and humanities | 501(c)(3) | 1980 | $3.7 million | $1.6 million | 2025-04 |
| Cooper School | Education | 501(c)(3) | 2007 | $3.7 million | $4.9 million | 2025-06 |
| Catholic Charities of South Carolina | 501(c)(3) | 1946 | $3.4 million | $5.5 million | 2025-06 | |
| Drayton Hall Preservation Trust | Human services | 501(c)(3) | 2015 | $3.2 million | $6.3 million | 2025-06 |
| The Cooper River Bridge Run Inc | Recreation and sports | 501(c)(3) | 1997 | $3.1 million | $3.1 million | 2025-06 |
| Mother Emanuel Memorial Foundation | Civil rights, social action and advocacy | 501(c)(3) | 2017 | $3.1 million | $19.5 million | 2024-12 |
| Charleston Redevelopment Corporation | Community improvement and capacity building | 501(c)(3) | 2012 | $3 million | $21.5 million | 2024-12 |
| Florence Crittenton Programs of South Carolina Inc | Human services | 501(c)(3) | 1945 | $2.9 million | $4 million | 2025-06 |
| Alumni Association of Medical University of SC | 501(c)(3) | 1953 | $2.9 million | $607,778 | 2025-06 | |
| Climb Fund | Community improvement and capacity building | 501(c)(3) | 2019 | $2.9 million | $38.9 million | 2025-09 |
| Charleston Development Acdemy | Education | 501(c)(3) | 2005 | $2.7 million | $1.5 million | 2025-06 |
| Association for the Blind and Visually Impaired South Carolina | 501(c)(3) | 1970 | $2.7 million | $1.3 million | 2025-06 | |
| Charleston Library Society | 501(c)(3) | 1941 | $2.5 million | $15 million | 2024-12 | |
| Trident Technical College Foundation Incorporated | Education | 501(c)(3) | 1981 | $2.5 million | $23.6 million | 2025-06 |
| Middleton Place Foundation | Arts, culture and humanities | 501(c)(3) | 1975 | $2.4 million | $44 million | 2025-06 |
| South Carolina Association for Community Economic Development | Community improvement and capacity building | 501(c)(3) | 1998 | $2.4 million | $2.2 million | 2025-12 |
| Childrens Museum of the Lowcountry | Arts, culture and humanities | 501(c)(3) | 1995 | $2.3 million | $4.8 million | 2024-12 |
| Charles Towne Montessori School | 501(c)(3) | 1973 | $2.2 million | $3.6 million | 2025-05 | |
| Charleston Parks Conservancy | Environment | 501(c)(3) | 2007 | $2.1 million | $9 million | 2025-12 |
| Charleston Literary Festival Inc | Arts, culture and humanities | 501(c)(3) | 2017 | $2.1 million | $1.4 million | 2025-12 |
| Episcopal Diocesan Housing Inc | Housing and shelter | 501(c)(3) | 1967 | $2.1 million | $4.5 million | 2025-12 |
| American Friends of Alumot-Or Sasa Setton and Cfji Inc | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 2022 | $2 million | $281,469 | 2025-12 |
| Allied Services Risk Retention Group | Health care | 501(c)(3) | 2005 | $2 million | $8 million | 2024-12 |
| James Island Soccer Club Inc | Recreation and sports | 501(c)(3) | 1981 | $2 million | $1.6 million | 2025-04 |
| Camp Happy Days Inc | 501(c)(3) | 1983 | $1.9 million | $5.1 million | 2025-09 | |
| Habitat for Humanity International Inc | 501(c)(3) | 1987 | $1.8 million | $3.3 million | 2025-06 | |
| Charleston Area Senior Citizens Services Inc | 501(c)(3) | 1967 | $1.8 million | $2.2 million | 2025-06 | |
| Charleston Jewish Federation | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 1952 | $1.8 million | $1.3 million | 2024-12 |
| The Citadel Alumni Association | Education | 501(c)(3) | 1979 | $1.8 million | $12.9 million | 2024-12 |
| Humanities Foundation Inc | Housing and shelter | 501(c)(3) | 1992 | $1.8 million | $36.7 million | 2024-12 |
| Charleston Digital Corridor Foundation | Community improvement and capacity building | 501(c)(6) | 2005 | $1.7 million | $5.4 million | 2025-12 |
| South Carolina Stevedores Association | 501(c)(6) | 1987 | $1.7 million | $1.4 million | 2025-12 | |
| International Longshoremens Association | 501(c)(5) | 1941 | $1.7 million | $4.1 million | 2024-12 | |
| South Carolina Historical Society | Arts, culture and humanities | 501(c)(3) | 1941 | $1.6 million | $11.5 million | 2025-12 |
| Helping and Lending Outreach Support | Mutual and membership benefit | 501(c)(3) | 2004 | $1.6 million | $1.3 million | 2025-06 |
| James Island Presbyterian Foundation | Human services | 501(c)(3) | 1985 | $1.6 million | $2.2 million | 2025-06 |
| Friends of the Lowline | Community improvement and capacity building | 501(c)(3) | 2016 | $1.6 million | $1.2 million | 2025-12 |
| Great Lakes Outreach Inc | Religion-related | 501(c)(3) | 2008 | $1.6 million | $495,125 | 2024-12 |
| Ansonborough Housing Corporation | 501(c)(3) | 1982 | $1.6 million | $7.3 million | 2025-12 | |
| Institute for Strategic and Equitable Development | Community improvement and capacity building | 501(c)(3) | 2015 | $1.6 million | $1.2 million | 2025-12 |
| Westedge Foundation Inc | Community improvement and capacity building | 501(c)(3) | 2011 | $1.5 million | $13.5 million | 2025-06 |
| Martha and John M Rivers Performance Hall Foundation | Arts, culture and humanities | 501(c)(3) | 2011 | $1.5 million | $13.9 million | 2025-06 |
| Heritage Community Services Inc | Education | 501(c)(3) | 1998 | $1.5 million | $583,293 | 2024-12 |
| Marine Science and Nauticaltraining Academy | Education | 501(c)(3) | 2007 | $1.5 million | $2.1 million | 2024-12 |
| Head & Neck Cancer Alliance Inc | Diseases, disorders and medical disciplines | 501(c)(3) | 2013 | $1.5 million | $2.7 million | 2025-12 |
| Coastal District Council of the St Vincent de Paul Society Diocese of | Human services | 501(c)(3) | 2003 | $1.4 million | $439,322 | 2024-12 |
| James Island Outreach | Housing and shelter | 501(c)(3) | 1991 | $1.4 million | $967,739 | 2025-12 |
| Kids On Point Inc | Recreation and sports | 501(c)(3) | 2010 | $1.4 million | $1.1 million | 2025-08 |
| Guam Education Financing Foundation Inc | Community improvement and capacity building | 501(c)(4) | 2014 | $1.4 million | $11.5 million | 2025-09 |
| James Island Yacht Club | Recreation and sports | 501(c)(7) | 1999 | $1.4 million | $3.9 million | 2025-09 |
| Trinity Montessori Christian School Inc | Education | 501(c)(3) | 2014 | $1.3 million | $1.4 million | 2025-07 |
| Lowcountry Orphan Relief | Human services | 501(c)(3) | 2007 | $1.3 million | $3.9 million | 2025-12 |
| S C Battleground Preservation Trust Inc | 501(c)(3) | 1994 | $1.3 million | $13.6 million | 2024-12 | |
| Pro Bono Legal Services Inc | Crime and legal-related | 501(c)(3) | 2004 | $1.2 million | $1.1 million | 2024-12 |
| Charleston Promise Neighborhood | Education | 501(c)(3) | 2011 | $1.2 million | $1.8 million | 2025-06 |
| Coastal Tourism Inc | 501(c)(6) | 1991 | $1.2 million | $623,987 | 2025-06 | |
| International Longshoremens Association | 501(c)(5) | 1941 | $1.1 million | $2.3 million | 2024-12 | |
| Engaging Creative Minds | Education | 501(c)(3) | 2014 | $1.1 million | $218,035 | 2025-08 |
| Sustainability Institute Inc | Community improvement and capacity building | 501(c)(3) | 2002 | $1.1 million | $1.1 million | 2024-12 |
| Green Heart Project Inc | Environment | 501(c)(3) | 2014 | $982,901 | $1.3 million | 2025-07 |
| JCC Housing Corporation | 501(c)(3) | 1982 | $981,040 | $2.9 million | 2024-12 | |
| Elizabeth L Battle Trust for St Philips Church | Religion-related | 501(c)(3) | 2023 | $966,785 | $10.8 million | 2025-12 |
| Charleston Downtown Alliance Inc | Environment | 501(c)(3) | 2025 | $950,537 | $534,516 | 2025-12 |
| Charleston Recovery Center Inc | Human services | 501(c)(3) | 2010 | $932,598 | $869,650 | 2025-12 |
| Lowcountry Food Bank Foundation | Food, agriculture and nutrition | 501(c)(3) | 2021 | $930,496 | $3.4 million | 2025-12 |
| Charleston Yacht Club Inc Charleston Municipal Marina 17 Loc | 501(c)(7) | 1963 | $926,572 | $305,800 | 2025-12 | |
| College of Charleston Alumni Association Inc | Education | 501(c)(3) | 1968 | $916,393 | $653,752 | 2025-06 |
| Ibu Foundation | International, foreign affairs and national security | 501(c)(3) | 2015 | $913,333 | $187,116 | 2024-12 |
| Fosters Child Care & Dev Center Inc | Human services | 501(c)(3) | 1993 | $908,350 | $3,908 | 2024-12 |
| South Carolina Economic Developers Association Inc | 501(c)(6) | 1967 | $885,241 | $695,687 | 2025-06 | |
| Goodcoin Giving Fund | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 2022 | $831,870 | $758,277 | 2024-12 |
| South Carolina Association of Public Charter Schools Inc | Education | 501(c)(3) | 2007 | $813,947 | $1 million | 2025-06 |
| YWCA of Greater Charleston | Human services | 501(c)(3) | 1971 | $797,303 | $11.7 million | 2025-06 |
| Pure Theatre | Arts, culture and humanities | 501(c)(3) | 2006 | $782,248 | $138,323 | 2025-06 |
| Iaam Support Organization | Arts, culture and humanities | 501(c)(3) | 2020 | $763,654 | $14 million | 2024-12 |
| Wahoo Aquatic Club Inc | Recreation and sports | 501(c)(3) | 2019 | $762,072 | $157,253 | 2024-12 |
| Charleston Rifle Club | 501(c)(7) | 1945 | $757,370 | $640,740 | 2024-12 | |
| Livity Foundation | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 2024 | $751,461 | $77,495 | 2025-12 |
| Association of Independent Research Institutes Inc | 501(c)(6) | 1989 | $748,626 | $2.4 million | 2025-12 | |
| National Exchange Club | 501(c)(4) | 1950 | $724,732 | $277,457 | 2025-06 | |
| Charleston Apartment Association | 501(c)(6) | 1996 | $692,911 | $697,977 | 2025-12 | |
| Benevolent & Protective Order of Elks of the USA | 501(c)(8) | 1951 | $690,720 | $1.8 million | 2026-03 | |
| Elderly Housing Inc | Housing and shelter | 501(c)(3) | 1997 | $679,121 | $3.3 million | 2025-12 |
| Redux Contemporary Art Center | Arts, culture and humanities | 501(c)(3) | 2002 | $678,314 | $183,091 | 2025-12 |
| Confederate Home and College | Housing and shelter | 501(c)(3) | 1951 | $677,583 | $7.4 million | 2024-12 |
| National Association for Continence | 501(c)(3) | 1984 | $645,858 | $455,188 | 2024-12 | |
| Fresh Future Farm Inc | Food, agriculture and nutrition | 501(c)(3) | 2015 | $592,654 | $657,869 | 2025-06 |
| Huguenot Society of South Carolina | Religion-related | 501(c)(3) | 1983 | $589,528 | $3.4 million | 2025-12 |
| Clinical Biotechnology Research Institute at RSFH | Medical research | 501(c)(3) | 2017 | $585,349 | $83,730 | 2024-12 |
| Saint James Day School Inc | Education | 501(c)(3) | 2013 | $582,508 | $230,488 | 2025-12 |
| Bishop Gadsden Episcopal Communities | Mutual and membership benefit | 501(c)(3) | 2024 | $579,200 | $3.6 million | 2025-12 |
| Respite Care of Charleston | Human services | 501(c)(3) | 2011 | $576,222 | $563,825 | 2025-12 |
| Footlight Players Inc | Arts, culture and humanities | 501(c)(3) | 1952 | $571,244 | $7.7 million | 2025-06 |
| Retirement Benefit Plan Trust for Employees of University Medical | Mutual and membership benefit | 501(c)(9) | 2010 | $561,910 | $3.8 million | 2025-06 |
| Jewish Family Services of Greater Charleston | Human services | 501(c)(3) | 2021 | $551,864 | $686,899 | 2025-12 |
| Colour of Music Inc | Arts, culture and humanities | 501(c)(3) | 2020 | $540,398 | $44,904 | 2024-12 |
| Charleston County Medical Society | 501(c)(6) | 1965 | $537,306 | $508,857 | 2025-06 | |
| Palmetto Recovery of Charleston | Mental health and crisis intervention | 501(c)(3) | 2024 | $528,120 | $758,265 | 2025-12 |
| Station Eight Insurance Company | Mutual and membership benefit | 501(c)(15) | 2025 | $523,505 | $1.3 million | 2025-12 |
| National Society of the Colonial Dames of America | Arts, culture and humanities | 501(c)(3) | 1968 | $520,859 | $2 million | 2025-03 |
| Charleston Academy of Music | Arts, culture and humanities | 501(c)(3) | 2003 | $513,398 | $876,544 | 2025-07 |
| Animal Helpers Retail Resale Store LLC | Animal-related | 501(c)(3) | 2014 | $512,374 | $99,301 | 2025-12 |
| The Palmetto Palace | Health care | 501(c)(3) | 2007 | $510,577 | $30,877 | 2025-12 |
| Association of Cancer Executives | Education | 501(c)(3) | 1996 | $506,725 | $350,173 | 2025-06 |
| Charleston Hope | Education | 501(c)(3) | 2014 | $501,344 | $265,147 | 2025-06 |
| Magnolia Cemetery Trust | 501(c)(13) | 1956 | $498,873 | $7.1 million | 2024-12 | |
| Abvi Foundation | Diseases, disorders and medical disciplines | 501(c)(3) | 2024 | $493,609 | $5.8 million | 2025-06 |
| William Enston Home | Housing and shelter | 501(c)(3) | 1936 | $492,435 | $5.4 million | 2024-12 |
| Chamber Music Charleston | Arts, culture and humanities | 501(c)(3) | 2006 | $488,792 | $392,468 | 2026-04 |
| Lowcountry Veterans Home | Health care | 501(c)(3) | 2019 | $485,383 | $656,025 | 2026-01 |
| Association of Cancer Center Administrators | Medical research | 501(c)(3) | 2022 | $478,615 | $155,515 | 2025-06 |
| Charleston Community Sailing Inc | Recreation and sports | 501(c)(3) | 2001 | $447,642 | $222,088 | 2025-12 |
| Washington Light Infantry of Charleston S C | 501(c)(4) | 1964 | $443,292 | $6.3 million | 2025-02 | |
| Hope and Health Akot South Sudan | Human services | 501(c)(3) | 2025 | $442,276 | $55,868 | 2025-12 |
| Mental Health Heroes | Mental health and crisis intervention | 501(c)(3) | 2009 | $437,415 | $318,465 | 2025-06 |
| Coastal Boys Council Inc | Youth development | 501(c)(3) | 1973 | $434,513 | $6.8 million | 2024-12 |
| Friends of Fisher House Charleston Inc | Health care | 501(c)(3) | 2013 | $432,814 | $861,789 | 2025-12 |
| Vantage Point Foundation | 501(c)(3) | 2017 | $430,946 | $374,279 | 2024-12 | |
| Camp Rise Above Inc | Recreation and sports | 501(c)(3) | 2010 | $411,457 | $713,413 | 2025-12 |
| South Carolina Community Capital Inc | Community improvement and capacity building | 501(c)(3) | 2006 | $404,190 | $1.4 million | 2024-12 |
| Trident Urban League Inc | Human services | 501(c)(3) | 1992 | $402,789 | $238,451 | 2025-12 |
| Government Finance Officers Association of South Carolina | Community improvement and capacity building | 501(c)(6) | 2014 | $398,391 | $292,976 | 2025-12 |
| W E H Incorporated | Housing and shelter | 501(c)(3) | 2011 | $393,556 | $494,942 | 2024-12 |
| Charleston Moves | Recreation and sports | 501(c)(3) | 2005 | $381,152 | $468,097 | 2025-12 |
| Friends of the Charleston County Library | Education | 501(c)(3) | 1984 | $380,695 | $410,444 | 2024-12 |
| Kairos Christian Academy | Religion-related | 501(c)(3) | 2022 | $373,956 | $94,564 | 2025-07 |
| Charleston Artist Guild | Arts, culture and humanities | 501(c)(3) | 1995 | $366,336 | $560,472 | 2025-04 |
| Black Food Truck Festival Foundation | Arts, culture and humanities | 501(c)(3) | 2022 | $362,930 | $114,719 | 2023-12 |
| Ebenezer Social Action & Community Development Enterprise | Human services | 501(c)(3) | 2002 | $359,020 | $2 million | 2025-05 |
| Order of the Eastern Star of South Carolina Grand Chapter | 501(c)(8) | 1971 | $353,973 | $6.3 million | 2026-04 | |
| The Society of Industrial and Office Realtors | 501(c)(6) | 2015 | $351,925 | $1.1 million | 2025-12 | |
| Building the Future of the Lowcountry | Housing and shelter | 501(c)(3) | 2024 | $350,879 | $250,351 | 2025-12 |
| Mad USA Inc | Crime and legal-related | 501(c)(3) | 2016 | $350,400 | $114,587 | 2024-12 |
| Amor Healing Kitchen Inc | Food, agriculture and nutrition | 501(c)(3) | 2018 | $349,724 | $119,180 | 2024-12 |
| Christian Coalition | 501(c)(3) | 1989 | $348,520 | $289,661 | 2023-12 | |
| Faces and Voices of Recovery Lowcountry Aka Favor Lowcountry | Mental health and crisis intervention | 501(c)(3) | 2018 | $331,231 | $93,091 | 2025-12 |
| South Carolina Aviation Association | 501(c)(6) | 1993 | $328,758 | $297,092 | 2024-12 | |
| Greystar Giving Inc | Human services | 501(c)(3) | 2010 | $325,210 | $7,116 | 2024-12 |
| Lowcountry Youth Services | Housing and shelter | 501(c)(3) | 2009 | $322,968 | $41,059 | 2025-06 |
| Saint Albans Chapel Society | Religion-related | 501(c)(3) | 2026 | $319,617 | $266,080 | 2026-06 |
| Third Serve Inc | Recreation and sports | 501(c)(3) | 2021 | $317,533 | $76,302 | 2025-12 |
| Sior Se Regional Convention Inc | Education | 501(c)(3) | 2020 | $313,262 | $527,275 | 2025-12 |
| Telagous Ministries | Religion-related | 501(c)(3) | 2022 | $311,600 | $348,829 | 2025-12 |
| Aquatic Booster Club of the Southern Marlins Racing Team Inc | Recreation and sports | 501(c)(3) | 2003 | $310,118 | $247,535 | 2025-12 |
| Charleston Horticultural Society | Environment | 501(c)(3) | 2001 | $299,636 | $552,237 | 2025-06 |
| Lowcountry Maritime Society | Education | 501(c)(3) | 2011 | $299,340 | $37,764 | 2025-06 |
| Remember | Religion-related | 501(c)(3) | 2006 | $292,969 | $625,827 | 2025-12 |
| The Navigation Center | Public and societal benefit | 501(c)(3) | 2015 | $290,266 | $5,628 | 2024-12 |
| Next Child Fund Inc | Human services | 501(c)(3) | 2007 | $289,371 | $4.9 million | 2026-03 |
| Junior League of Charleston Inc | Community improvement and capacity building | 501(c)(3) | 1945 | $287,018 | $1.1 million | 2025-05 |
| Good Friends of the Lowcountry | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 2016 | $286,427 | $255,053 | 2024-12 |
| Government Finance Officers Association of Pennsylvania | Education | 501(c)(3) | 2005 | $280,277 | $462,900 | 2024-12 |
| Foundation for Spirituality and the Arts Inc | Arts, culture and humanities | 501(c)(3) | 2021 | $279,463 | $66,339 | 2025-12 |
| Dental Community Fellowship | Religion-related | 501(c)(3) | 2021 | $267,836 | $183,402 | 2026-06 |
| The Village Repertory Co | Arts, culture and humanities | 501(c)(3) | 2003 | $266,897 | $22,141 | 2024-12 |
| Ralph H Johnson American Legion Post 147 | 501(c)(19) | 1946 | $265,557 | $363,081 | 2025-12 | |
| Parkshore Swim and Racquet Club Inc | Recreation and sports | 501(c)(7) | 2017 | $263,281 | $184,192 | 2022-12 |
| Westover Apartments Inc | 501(c)(3) | 1989 | $260,698 | $427,608 | 2025-12 | |
| Bens Friends | Mental health and crisis intervention | 501(c)(3) | 2018 | $260,079 | $210,082 | 2024-12 |
| Journey Home Rescue Alliance | Animal-related | 501(c)(3) | 2024 | $256,705 | $85,938 | 2025-12 |
| Hibernian Society of Charleston Foundation Inc | 501(c)(3) | 1982 | $252,029 | $2.6 million | 2025-12 | |
| Scottish Society of Charleston Inc | Arts, culture and humanities | 501(c)(3) | 2019 | $251,577 | $18,536 | 2025-12 |
| South Carolina Academy of Physicians Assistants | 501(c)(6) | 1978 | $251,253 | $139,966 | 2025-06 | |
| Medical Missions Inc | International, foreign affairs and national security | 501(c)(3) | 1993 | $251,128 | $200,817 | 2024-12 |
| Community College Business Officers | Education | 501(c)(6) | 2005 | $245,306 | $271,637 | 2024-12 |
| Charleston County Bar Association Inc | 501(c)(6) | 1991 | $239,866 | $237,627 | 2024-12 | |
| Carolina Basset Hound Rescue Inc | Animal-related | 501(c)(3) | 1999 | $236,204 | $146,478 | 2025-12 |
| Dragon Boat Charleston | Diseases, disorders and medical disciplines | 501(c)(3) | 2009 | $235,377 | $275,071 | 2025-09 |
| Carolina Childrens Charity Inc | Diseases, disorders and medical disciplines | 501(c)(3) | 1989 | $227,330 | $699,334 | 2025-09 |
| Teachers Supply Closet | Human services | 501(c)(3) | 2007 | $225,365 | $103,310 | 2025-12 |
| Bridge Between Animal Rescue | Animal-related | 501(c)(3) | 2022 | $224,240 | $5,683 | 2024-12 |
| Charleston Center for Paleontology | Science and technology | 501(c)(3) | 2024 | $221,021 | $92,189 | 2024-12 |
| The Propeller Club of the United States of Charleston SC | 501(c)(6) | 1985 | $219,450 | $118,677 | 2025-06 | |
| Ancient & Accepted Scottish Rite of Free Masonry Southern Juris | 501(c)(10) | 1940 | $214,657 | $1.5 million | 2025-12 | |
| Knights of Columbus | 501(c)(8) | 1940 | $213,082 | $341,853 | 2024-12 | |
| Adoption Options Inc | Education | 501(c)(3) | 1997 | $210,716 | $34,839 | 2025-12 |
| Charleston County Parks Foundation Inc | Arts, culture and humanities | 501(c)(3) | 2014 | $206,401 | $698,248 | 2025-06 |
| E3 Educate-Empower-Elevate | Education | 501(c)(3) | 2022 | $206,364 | $14,755 | 2024-12 |
| Yallfest Charleston | Arts, culture and humanities | 501(c)(3) | 2013 | $200,168 | $71,781 | 2025-06 |
| This Is Noteworthy | Human services | 501(c)(3) | 2015 | $198,881 | $199,016 | 2024-12 |
| Jewish Studies Center Inc | Community improvement and capacity building | 501(c)(3) | 2002 | $198,299 | $1.2 million | 2024-12 |
| Charleston Peninsula Preservation Trust | Community improvement and capacity building | 501(c)(3) | 2010 | $197,275 | $51,434 | 2025-05 |
| Charleston Resturant Foundation Inc | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 2012 | $191,712 | $213,427 | 2025-06 |
| South Carolina Association of Licensed Trades Inc | 501(c)(6) | 1989 | $190,376 | $226,721 | 2025-12 | |
| Christian Coalition of America Inc | 501(c)(4) | 1992 | $190,305 | $12,216 | 2023-12 | |
| International Abba Ministries | Mental health and crisis intervention | 501(c)(3) | 2015 | $189,524 | $52,056 | 2025-12 |
| Affordable Housing Trust | Housing and shelter | 501(c)(3) | 2016 | $188,794 | $1.2 million | 2024-12 |
| Charleston Presbyterian Church | Religion-related | 501(c)(3) | 2013 | $188,375 | $230,811 | 2023-12 |
| Charleston Symphony Orchestra League Inc | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 2004 | $186,555 | $89,893 | 2025-06 |
| Rotary International | 501(c)(4) | 1964 | $185,640 | $82,931 | 2025-06 | |
| Exchange Club of Charleston Foundation Inc | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 1995 | $183,899 | $1.2 million | 2025-06 |
| Fields To Families | Human services | 501(c)(3) | 2007 | $183,729 | $127,916 | 2024-12 |
| Society of Colonial Wars in the State of South Carolina Inc | Arts, culture and humanities | 501(c)(3) | 2010 | $183,694 | $407,992 | 2025-03 |
| Comprehensive Psychiatric Care Specialists | Health care | 501(c)(3) | 2015 | $182,490 | $69,809 | 2025-06 |
| Kappa Alpha Order | 501(c)(7) | 1940 | $179,599 | $8,872 | 2025-06 | |
| Iglesia Bautista La Victoria | Religion-related | 501(c)(3) | 2018 | $179,137 | $550,732 | 2024-12 |
| Post Partum Support Charleston | Human services | 501(c)(3) | 2011 | $177,883 | $52,896 | 2025-06 |
| The Citadel Football Association Inc | 501(c)(3) | 1986 | $177,597 | $140,599 | 2024-12 | |
| South Carolina Society of Anesthesiologists | Education | 501(c)(6) | 2026 | $172,943 | $351,391 | 2020-12 |
| Phoebe Pember Foundation | Human services | 501(c)(3) | 2004 | $172,202 | $133,954 | 2024-12 |
| Be A Mentor Inc | Youth development | 501(c)(3) | 2016 | $171,601 | $96,269 | 2025-12 |
| Rock the Block | Diseases, disorders and medical disciplines | 501(c)(3) | 2021 | $168,421 | $92,381 | 2025-12 |
| West Ashley-Charleston | 501(c)(4) | 1942 | $168,310 | $835,717 | 2025-06 | |
| Family Resource Center for Disabili Disabilities and Special Needs Inc | Human services | 501(c)(3) | 2001 | $167,724 | $4,050 | 2024-12 |
| Pi Kappa Phi Fraternity | 501(c)(7) | 1991 | $165,704 | $14,347 | 2025-12 | |
| Orange Grove Elementary Charter School Pto | Education | 501(c)(3) | 2015 | $160,173 | $84,741 | 2025-07 |
| Sigma Delta Pi | Youth development | 501(c)(3) | 1999 | $158,914 | $1.6 million | 2025-08 |
| Northeast Region Burn Conference Planning Organization | Education | 501(c)(3) | 2017 | $150,398 | $55,926 | 2025-12 |
| Lets Walk | Health care | 501(c)(3) | 2022 | $149,464 | $76,721 | 2025-12 |
| Doors To Dream | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 2016 | $147,792 | $126,357 | 2024-12 |
| Sanatan Temple and Cultural Centerof South Carolina | Religion-related | 501(c)(3) | 2007 | $145,182 | $432,798 | 2016-12 |
| Jewish Community Center of Charleston SC 1645 Wallenberg BLVD | 501(c)(3) | 1962 | $144,875 | $2.8 million | 2025-12 | |
| Hoofprints in the Sand Inc | Health care | 501(c)(3) | 2023 | $144,369 | $18,607 | 2024-12 |
| Circular Congregational Church Endowment Inc | Religion-related | 501(c)(3) | 2014 | $142,456 | $1.5 million | 2024-12 |
| Palmetto Professional Society of Charleston II | Community improvement and capacity building | 501(c)(4) | 2014 | $140,000 | $32,750 | 2024-12 |
| The German Friendly Society of Charleston SC | 501(c)(4) | 1987 | $139,820 | $990,755 | 2025-12 | |
| Cusabo Nation Lacrosse | Recreation and sports | 501(c)(3) | 2015 | $137,317 | $13,333 | 2026-06 |
| Loving Work Foundation | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 2014 | $135,960 | $46,625 | 2024-12 |
| Lowcountry Housing and Economic Development Foundation Inc | Housing and shelter | 501(c)(3) | 1997 | $135,400 | $919,963 | 2023-12 |
| International Alliance Theatrical Stage Employees & Moving Picture | 501(c)(5) | 1967 | $134,611 | $167,152 | 2024-12 | |
| Youth Empowerment Services Inc | Human services | 501(c)(3) | 2000 | $134,360 | $36,551 | 2024-12 |
| Bright Spot Sober Living Inc | Mental health and crisis intervention | 501(c)(3) | 2023 | $131,692 | $26,474 | 2025-12 |
| James Island High School Booster Club Inc | Education | 501(c)(3) | 2014 | $129,707 | $52,889 | 2024-12 |
| Charleston Climate Coalition | Public and societal benefit | 501(c)(3) | 2021 | $129,078 | $21,554 | 2025-12 |
| Carolina Emergency Response Team | Public safety, disaster preparedness and relief | 501(c)(3) | 2024 | $126,481 | $14,986 | 2024-12 |
| Cainhoy Athletic Soccer Club | Recreation and sports | 501(c)(3) | 2009 | $126,436 | $23,667 | 2025-12 |
| Historic Mother Emanuel Amec Foundation | Arts, culture and humanities | 501(c)(3) | 2017 | $126,030 | $203,209 | 2025-12 |
| Lena Warren Schaefer Trust Uw 1051501 | 501(c)(91) | $124,548 | $3.4 million | 2021-09 | ||
| Quest in Recovery | Mental health and crisis intervention | 501(c)(3) | 2022 | $124,108 | $4,117 | 2025-12 |
| United Daughters of the Confederacy | 501(c)(3) | 1967 | $120,897 | $343,802 | 2025-09 | |
| Peninsula Biblical Counseling Ministries | Human services | 501(c)(3) | 2015 | $120,562 | $120,899 | 2025-12 |
| Second Chance Bikes | Human services | 501(c)(3) | 2018 | $119,501 | $67,475 | 2024-12 |
| Friends Charleston National Parks | Environment | 501(c)(3) | 2001 | $117,571 | $278,040 | 2025-12 |
| South Carolina Congress of Parents and Teachers | 501(c)(3) | 1979 | $115,873 | $23,997 | 2026-06 | |
| Charleston Bridge Club Inc | Recreation and sports | 501(c)(3) | 2000 | $115,791 | $483,581 | 2025-12 |
| Taylor Music Group | Arts, culture and humanities | 501(c)(3) | 2001 | $112,918 | $7,374 | 2025-06 |
| Birthright of Charleston | 501(c)(3) | 1976 | $110,990 | $162,152 | 2024-12 | |
| American Legion | 501(c)(19) | $110,696 | $599,066 | 2025-12 | ||
| Veterans On Deck | Education | 501(c)(3) | 2011 | $109,827 | $28,912 | 2026-06 |
| Low Country Dog Agility of Greater Charleston SC Inc | Animal-related | 501(c)(3) | 2015 | $109,344 | $379,142 | 2025-12 |
| Charleston Ocean Racing Association Inc | Education | 501(c)(3) | 2014 | $107,812 | $331,896 | 2025-12 |
| Green and Healthy Inc | Education | 501(c)(3) | 2020 | $106,872 | $380,083 | 2025-06 |
| Lowcountry Mediation Center | Religion-related | 501(c)(3) | 2008 | $106,113 | $80,412 | 2025-12 |
| Compass Harbor | Housing and shelter | 501(c)(3) | 2021 | $105,974 | $75,956 | 2025-06 |
| South Carolina Association of Health Underwriters | 501(c)(6) | 1996 | $105,893 | $128,564 | 2025-06 | |
| Triple B Club for Bishop England High | Education | 501(c)(3) | 2002 | $105,873 | $189,335 | 2025-05 |
| Carolina Coonhound Rescue | Animal-related | 501(c)(3) | 2014 | $105,030 | $51,738 | 2025-05 |
| Carolinas Payroll Conference | Education | 501(c)(3) | 2009 | $103,947 | $65,265 | 2025-12 |
| Girls On the Run Charleston | Youth development | 501(c)(3) | 2018 | $103,690 | $41,044 | 2025-06 |
| Trident Ceo Council | Community improvement and capacity building | 501(c)(4) | 2006 | $101,701 | $202,931 | 2025-12 |
| Buist Academy Foundation | Education | 501(c)(3) | 2002 | $101,683 | $491,038 | 2025-06 |
| Carolinas Association of Provider Services Inc | Community improvement and capacity building | 501(c)(6) | 2017 | $100,706 | $150,524 | 2025-09 |
| James Island Charter Highschool Band Backer Association | Arts, culture and humanities | 501(c)(3) | 2003 | $100,101 | $22,280 | 2025-04 |
| Experiencecharleston Org Inc | Education | 501(c)(3) | 2018 | $100,032 | $5,817 | 2025-12 |
| Charleston Rotary Fund | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 1997 | $99,864 | $515,190 | 2025-06 |
| JDW Network | Community improvement and capacity building | 501(c)(3) | 2003 | $98,887 | $5,577 | 2025-12 |
| The Society of Cincinnati of the State of South Carolina | 501(c)(3) | 1987 | $98,291 | $876,536 | 2024-12 | |
| Charleston Youth Company Inc | 501(c)(3) | 1990 | $96,723 | $30,242 | 2025-06 | |
| Josh Nass Family Foundation Inc | Religion-related | 501(c)(3) | 2026 | $95,650 | $2,102 | 2021-12 |
| Aia Charleston | Community improvement and capacity building | 501(c)(6) | 2023 | $94,720 | $170,220 | 2024-12 |
| Middleton Hunting Club Inc W C Helms III | 501(c)(7) | 1994 | $94,295 | $66,685 | 2026-04 | |
| Sigma Nu Fraternity | 501(c)(7) | 1940 | $93,639 | $23,500 | 2024-12 | |
| Miami Realty Association of Alpha Delta Phi | 501(c)(7) | 1967 | $93,578 | $496,886 | 2026-06 | |
| Kaizen Way Inc | Recreation and sports | 501(c)(3) | 2018 | $93,510 | $792 | 2025-12 |
| Rotary International | 501(c)(4) | 1942 | $92,418 | $83,109 | 2025-06 | |
| Saras Cure | Medical research | 501(c)(3) | 2018 | $91,784 | $51,801 | 2024-12 |
| Self Storage Association of South Carolina | Community improvement and capacity building | 501(c)(6) | 2017 | $91,537 | $121,411 | 2024-12 |
| Charleston Development Board Foundation | 501(c)(6) | 1966 | $91,467 | $941,315 | 2025-12 | |
| East Edisto Conservancy Inc | Environment | 501(c)(4) | 2015 | $91,292 | $3.2 million | 2025-12 |
| First Baptist Church Foundation | Religion-related | 501(c)(3) | 2025 | $91,149 | $5 million | 2025-05 |
| Charleston Leaders Foundation Inc | Community improvement and capacity building | 501(c)(3) | 2018 | $90,807 | $19,316 | 2024-12 |
| Media Reform SC Inc | Arts, culture and humanities | 501(c)(3) | 2014 | $90,717 | $114,629 | 2025-12 |
| Coastal Harvest Church | 501(c)(3) | 1964 | $90,572 | $18,276 | 2021-12 | |
| Yo Art Inc | Youth development | 501(c)(3) | 2010 | $89,340 | $1,670 | 2025-06 |
| Threshold Repertory Theatre | Arts, culture and humanities | 501(c)(3) | 2025 | $87,501 | $1,367 | 2024-12 |
| West Ashley Outboard Motor Club Johns Island S C | 501(c)(4) | 1976 | $87,284 | $400,509 | 2026-02 | |
| Charleston Leadership Foundation | Religion-related | 501(c)(3) | 2004 | $86,534 | $412,117 | 2025-12 |
| Islands Against Cancer Inc | Health care | 501(c)(3) | 2022 | $85,653 | $32,717 | 2025-12 |
| VC Expeditions | Science and technology | 501(c)(3) | 2025 | $85,000 | $15,985 | 2025-12 |
| International Association of Fire Fighters | 501(c)(5) | 1959 | $84,486 | $51,817 | 2022-12 | |
| Charleston Area Hospitality Association | Community improvement and capacity building | 501(c)(6) | 2010 | $84,000 | $113,742 | 2025-06 |
| Pta South Carolina Congress | 501(c)(3) | 1979 | $82,614 | $39,107 | 2025-06 | |
| Pta South Carolina Congress | 501(c)(3) | 1979 | $81,907 | $28,581 | 2025-06 | |
| South Carolina Radiological Society | 501(c)(6) | 1970 | $79,179 | $183,640 | 2025-12 | |
| Adaptive Expeditions | Recreation and sports | 501(c)(3) | 2013 | $78,533 | $37,258 | 2024-12 |
| Charleston Mens Chorus Inc | Human services | 501(c)(3) | 1998 | $77,803 | $183,684 | 2025-06 |
| Ji Lil Trojans | Youth development | 501(c)(3) | 2024 | $77,324 | $1 | 2025-05 |
| Carolina Assembly | Recreation and sports | 501(c)(7) | 2014 | $75,659 | $114,297 | 2026-01 |
| Links Inc | 501(c)(4) | 1961 | $74,731 | $178,387 | 2025-04 | |
| Hands of Christ | Food, agriculture and nutrition | 501(c)(3) | 2006 | $74,011 | $220,689 | 2025-09 |
| Pickles People Inc | Diseases, disorders and medical disciplines | 501(c)(3) | 2021 | $72,755 | $74,475 | 2024-12 |
| Be the Change Charleston Inc | Diseases, disorders and medical disciplines | 501(c)(3) | 2019 | $72,718 | $15,126 | 2025-12 |
| Holy City Wellbeing | Mental health and crisis intervention | 501(c)(3) | 2019 | $72,455 | $9,972 | 2026-01 |
| Charleston Boxing Foundation | Arts, culture and humanities | 501(c)(3) | 2023 | $72,328 | $14,807 | 2025-05 |
| Charleston County Masonic Association Inc | Community improvement and capacity building | 501(c)(3) | 2024 | $70,884 | $548,039 | 2025-12 |
| Georgia Radiological Society Inc | 501(c)(6) | 1975 | $69,943 | $284,924 | 2025-05 | |
| Fellowship Society | 501(c)(4) | 2005 | $69,270 | $742,105 | 2025-02 | |
| Carolina Ocean Alliance | Environment | 501(c)(3) | 2023 | $69,079 | $19,902 | 2025-12 |
| Friends of the Muni Inc | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 2019 | $68,924 | $649,748 | 2025-12 |
| National Exchange Club | 501(c)(4) | 1950 | $68,174 | $11,641 | 2025-06 | |
| Springfield Elementary School Pta | Education | 501(c)(3) | 2025 | $67,776 | $18,207 | 2026-06 |
| Team Nelson Inc | Education | 501(c)(3) | 2018 | $67,430 | $100,816 | 2025-12 |
| Emergency Nurses Association | Education | 501(c)(3) | 2003 | $67,418 | $164,106 | 2025-12 |
| St James Santee Brick Churchrestoration and Preservation Commit | Religion-related | 501(c)(3) | 2007 | $66,348 | $1 million | 2025-12 |
| Pro-Life Charleston | Health care | 501(c)(3) | 2017 | $66,171 | $44,728 | 2025-06 |
| CDC Education Foundation | Science and technology | 501(c)(3) | 2015 | $65,499 | $107,805 | 2025-12 |
| Family Collective Limited | Public and societal benefit | 501(c)(3) | 2020 | $64,513 | $7,583 | 2025-12 |
| Charleston Area Sports Commission | Community improvement and capacity building | 501(c)(6) | 2014 | $63,502 | $146,124 | 2025-06 |
| Charleston Club | 501(c)(7) | 1945 | $62,376 | $268,422 | 2025-11 | |
| Lowcountry Aquatic Project Swimming Inc | Recreation and sports | 501(c)(3) | 2017 | $62,371 | $5,150 | 2024-12 |
| Eclt Foundation | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 2016 | $62,224 | $2.2 million | 2025-06 |
| Ladies Enriching the Community | Youth development | 501(c)(3) | 2001 | $61,711 | $509,445 | 2025-12 |
| Charleston County Farm Bureau | 501(c)(5) | 1973 | $61,496 | $866,570 | 2024-12 | |
| Annex Dance Company | Arts, culture and humanities | 501(c)(3) | 2026 | $59,140 | $1,310 | 2024-12 |
| Waves 4 Women | Mental health and crisis intervention | 501(c)(3) | 2019 | $58,726 | $33,418 | 2024-12 |
| Global Alliance for South Carolina | International, foreign affairs and national security | 501(c)(3) | 2017 | $58,335 | $131,634 | 2024-12 |
| Lowcountry Warrior Moms | Human services | 501(c)(3) | 2017 | $57,814 | $25,758 | 2025-12 |
| Alpha Nu House Corporation of Delta | 501(c)(7) | 1959 | $57,810 | $274,612 | 2026-05 | |
| Mere Anglicanism | Religion-related | 501(c)(3) | 2007 | $57,705 | $96,578 | 2024-12 |
| Soldiers of Hope Inc | Human services | 501(c)(3) | 2024 | $57,523 | $21,587 | 2025-12 |
| Charleston St Patricks Day Parade Committee Incorporated | Recreation and sports | 501(c)(3) | 2017 | $56,836 | $57,650 | 2025-12 |
| Parent Booster USA Inc | Education | 501(c)(3) | 2005 | $56,683 | $13,827 | 2025-06 |
| Amazing Maasai Girls Project | Education | 501(c)(3) | 2011 | $56,418 | $756,387 | 2025-12 |
| Ideas To Inspire | Arts, culture and humanities | 501(c)(3) | 2017 | $55,497 | $3,951 | 2024-12 |
| Memminger School of Global Studies | Education | 501(c)(3) | 2022 | $55,148 | $8,239 | 2026-02 |
| Chs4ukraine | International, foreign affairs and national security | 501(c)(3) | 2022 | $54,773 | $47,016 | 2025-12 |
| Philip Simmons High School Band Booster | Education | 501(c)(3) | 2019 | $54,713 | $92,936 | 2026-06 |
| People in Partnership | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 2010 | $53,871 | $32,819 | 2025-12 |
| Toadfish Outfitters Conservation Coalition Inc | Education | 501(c)(3) | 2020 | $53,795 | $45,634 | 2024-12 |
| American Board of Professional Liability Attorneys | 501(c)(6) | 1977 | $52,360 | $117,389 | 2026-02 | |
| Lowcountry Lab Rescue | Animal-related | 501(c)(3) | 2004 | $51,804 | $13,180 | 2024-12 |
| Next It Girl | Youth development | 501(c)(3) | 2019 | $51,403 | $35,649 | 2024-12 |
| Increasing Faith Christian Center | Religion-related | 501(c)(3) | 2014 | $51,262 | $8,593 | 2024-12 |
| The Charleston Chapter of the Csi Inc | Community improvement and capacity building | 501(c)(6) | 2022 | $50,040 | $66,836 | 2025-06 |
| World Affairs Council of Charleston | International, foreign affairs and national security | 501(c)(3) | 2003 | $48,041 | $74,394 | 2025-06 |
| Piccolo Spoleto Outdoor Art Exhibition Inc | Arts, culture and humanities | 501(c)(3) | 2025 | $46,445 | $8,501 | 2025-12 |
| Project Cool Breeze | Housing and shelter | 501(c)(3) | 2019 | $45,805 | $38,862 | 2025-12 |
| Robert Bosch Fair Share Fund | Human services | 501(c)(3) | 2025 | $45,642 | $69,169 | 2025-12 |
| Robert Ivey Ballet Inc | Arts, culture and humanities | 501(c)(3) | 2025 | $44,391 | $550 | 2017-03 |
| Knights Parent Guild | Education | 501(c)(3) | 1997 | $44,309 | $85,333 | 2025-06 |
| Herindependence | Housing and shelter | 501(c)(3) | 2017 | $43,914 | $531,510 | 2025-12 |
| Colin MCK Grant Home | Housing and shelter | 501(c)(3) | 1956 | $43,514 | $476,726 | 2026-03 |
| Lowcountry Community Chaplaincy | Religion-related | 501(c)(3) | 2017 | $42,475 | $9,915 | 2026-03 |
| Womens Council of Realtors Coastal SC | Mutual and membership benefit | 501(c)(6) | 2023 | $38,636 | $24,604 | 2024-12 |
| Homeless To Hope Center | Human services | 501(c)(3) | 2023 | $38,516 | $74,959 | 2025-12 |
| Charleston Women in International Trade | Community improvement and capacity building | 501(c)(6) | 2016 | $38,263 | $16,236 | 2023-12 |
| German Friendly Society Foundation | Education | 501(c)(3) | 2012 | $37,907 | $482,425 | 2025-12 |
| Company Company LLC | Arts, culture and humanities | 501(c)(3) | 2004 | $37,417 | $38,041 | 2024-12 |
| Friends of Keep Charleston Beautiful | Environment | 501(c)(3) | 2007 | $37,305 | $38,890 | 2025-12 |
| Reid House of Christian Service | Human services | 501(c)(3) | 1971 | $36,696 | $458,428 | 2024-12 |
| Wando-Huger Community Development Corporation | Community improvement and capacity building | 501(c)(3) | 2017 | $36,263 | $60,432 | 2025-12 |
| CCL Farm Conservation Inc | Environment | 501(c)(3) | 2024 | $35,732 | $4.8 million | 2025-06 |
| South Haven Management | Housing and shelter | 501(c)(3) | 2011 | $35,454 | $134,989 | 2024-12 |
| Catalyst Foundation | Community improvement and capacity building | 501(c)(3) | 2021 | $35,005 | $7,821 | 2025-06 |
| T O Missions Worldwide Inc | Health care | 501(c)(3) | 2024 | $34,740 | $22,683 | 2024-12 |
| Carolina Lady Anglers | Recreation and sports | 501(c)(3) | 2014 | $34,602 | $41,246 | 2025-12 |
| Charleston Tibetan Society Inc | Human services | 501(c)(3) | 1996 | $32,909 | $275,775 | 2025-12 |
| Heal With Hearts | Human services | 501(c)(3) | 2014 | $32,835 | $9,857 | 2025-12 |
| Concerned Citizens of Sol-Legarefoundation | Community improvement and capacity building | 501(c)(3) | 2025 | $31,628 | $33,174 | 2025-12 |
| The Garden Club of Charleston Charitable Fund | Arts, culture and humanities | 501(c)(3) | 2001 | $31,252 | $418,667 | 2025-05 |
| Knights of Columbus | 501(c)(8) | 1940 | $30,860 | $67,379 | 2025-12 | |
| Oakland Elementary Pto | Education | 501(c)(3) | 2021 | $30,372 | $20,144 | 2025-06 |
| Gallant Evangelistic Ministries Inc | Religion-related | 501(c)(3) | 1999 | $30,185 | $1,623 | 2025-12 |
| Jazz Changes Inc | Arts, culture and humanities | 501(c)(3) | 2023 | $29,988 | $1 | 2025-12 |
| Abundantly More Childrens Closet | Human services | 501(c)(3) | 2024 | $29,785 | $12,728 | 2025-12 |
| The Hebrew Benevolent Society of Charleston South Carolina | 501(c)(3) | 1989 | $29,657 | $409,606 | 2024-12 | |
| Country Club of Charleston Employee Assistance Fund Incorporated | Education | 501(c)(3) | 2020 | $28,810 | $224,508 | 2025-12 |
| Charleston Carriage Horse Advocates | Animal-related | 501(c)(3) | 2017 | $28,590 | $227 | 2024-12 |
| Happy Days Foundation Inc | 501(c)(3) | 1993 | $28,214 | $477,163 | 2025-09 | |
| We All Help | Public safety, disaster preparedness and relief | 501(c)(3) | 2024 | $27,525 | $537 | 2024-12 |
| Clean Slate Living | Youth development | 501(c)(3) | 2014 | $26,733 | $7,060 | 2025-09 |
| Nehemiah Lodge No 51 F 7 Am | 501(c)(10) | 1992 | $26,420 | $354,772 | 2024-12 | |
| Athletic Association of St Joseph | Recreation and sports | 501(c)(3) | 2001 | $25,823 | $99,098 | 2025-06 |
| Barbrewgrass | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 2021 | $25,605 | $21,984 | 2024-12 |
| Hammer Out Pediatric Cancer Corp | Health care | 501(c)(3) | 2019 | $25,569 | $1 | 2023-12 |
| Arion Society | 501(c)(7) | 1963 | $25,388 | $179,705 | 2025-12 | |
| Harbors of Hope | Mental health and crisis intervention | 501(c)(3) | 2024 | $24,608 | $10,477 | 2026-06 |
| South Carolina Hispanic & Latino Bar Association | Community improvement and capacity building | 501(c)(6) | 2026 | $24,422 | $12,883 | 2026-08 |
| Charleston Area Model Railroad Club Inc | Education | 501(c)(3) | 2016 | $24,005 | $130,584 | 2025-12 |
| Charleston Golf Inc | 501(c)(6) | 1998 | $23,014 | $216,252 | 2025-06 | |
| Burke High School Foundation | Education | 501(c)(3) | 2015 | $22,750 | $47,916 | 2024-12 |
| Twenty Pearls Foundation of Charleston Inc | Human services | 501(c)(3) | 2006 | $22,389 | $16,113 | 2024-12 |
| Lowcountry Senior Coalition | Human services | 501(c)(3) | 1998 | $22,283 | $122,518 | 2025-12 |
| Lowcountry Food Bank Property Holdings Inc | Food, agriculture and nutrition | 501(c)(3) | 2024 | $22,166 | $9 million | 2024-12 |
| Charleston Miracle League Inc | Recreation and sports | 501(c)(3) | 2003 | $22,003 | $492,166 | 2025-12 |
| Root Down Building Collective | Housing and shelter | 501(c)(3) | 2023 | $21,728 | $2,370 | 2026-06 |
| Charleston Day School Parentscouncil | Education | 501(c)(3) | 2006 | $21,594 | $21,273 | 2025-07 |
| State Child Care Administrators Network | Education | 501(c)(3) | 2016 | $21,000 | $77,165 | 2025-12 |
| Charleston Sister Cities International Inc | International, foreign affairs and national security | 501(c)(3) | 2017 | $20,530 | $5,878 | 2025-12 |
| Disaster Anesthesia Inc | Health care | 501(c)(3) | 2025 | $20,397 | $4,163 | 2025-12 |
| Coastal Cyclists | Recreation and sports | 501(c)(3) | 2008 | $18,835 | $11,283 | 2025-12 |
| Daniel Island Business Association | Community improvement and capacity building | 501(c)(6) | 2007 | $18,185 | $2,718 | 2025-12 |
| Eastside Community Development Corp Oration | Community improvement and capacity building | 501(c)(3) | 2026 | $17,759 | $435 | 2024-12 |
| The 20 20 Youth Nonprofit Organization | Recreation and sports | 501(c)(3) | 2020 | $17,570 | $19,237 | 2025-12 |
| Charleston Heritage Foundation | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 2001 | $17,538 | $59,241 | 2025-06 |
| The Harry and Reba Huge Foundation | Education | 501(c)(3) | 2006 | $16,902 | $435,107 | 2024-12 |
| SC Division of the International Association for Identification | Science and technology | 501(c)(3) | 2017 | $16,709 | $32,593 | 2024-12 |
| Charleston Running Club Inc | Recreation and sports | 501(c)(3) | 2016 | $15,502 | $28,208 | 2025-12 |
| Pile Driving Contractors Association of South Carolina | Community improvement and capacity building | 501(c)(6) | 2008 | $14,618 | $9,820 | 2025-12 |
| Impact Legends Basketball | Recreation and sports | 501(c)(3) | 2024 | $14,536 | $1,116 | 2025-12 |
| Charleston Concert Association | Arts, culture and humanities | 501(c)(3) | 1970 | $13,977 | $385 | 2026-04 |
| First Baptist School Foundation | Education | 501(c)(3) | 2012 | $13,882 | $783,766 | 2025-05 |
| Ace Mentory Program of Greater Charleston Inc | Education | 501(c)(3) | 2014 | $13,004 | $11,423 | 2025-06 |
| The Mission Collective Inc | Human services | 501(c)(3) | 2006 | $12,752 | $82,903 | 2025-12 |
| Brooks Haven Management Corporation | Human services | 501(c)(3) | 2020 | $11,524 | $68,116 | 2025-12 |
| Iron Wolf Recovery Fitness | 501(c)(3) | 2020 | $11,318 | $17,817 | 2024-12 | |
| Fort Johnson Estates Civic Club | 501(c)(4) | 1964 | $8,903 | $367,098 | 2025-12 | |
| You Keep Hope Alive | Human services | 501(c)(3) | 2023 | $8,418 | $3,172 | 2023-12 |
| Kenya Village Connection | International, foreign affairs and national security | 501(c)(3) | 2011 | $8,153 | $68 | 2025-12 |
| Mod Dental Aesthetics | Diseases, disorders and medical disciplines | 501(c)(3) | 2023 | $8,000 | $211,425 | 2025-12 |
| Charleston Women in Tech | Education | 501(c)(3) | 2016 | $7,481 | $52,771 | 2024-12 |
| St James Foundation | Human services | 501(c)(3) | 1999 | $7,478 | $856,500 | 2025-12 |
| Neighborhood Legal Assistance Inc | Crime and legal-related | 501(c)(3) | 1974 | $6,814 | $150,556 | 2024-12 |
| Charles Town Landing Foundation | 501(c)(3) | 1977 | $6,775 | $28,838 | 2025-06 | |
| Home Grown Radio | Arts, culture and humanities | 501(c)(3) | 2025 | $6,000 | $14,357 | 2025-12 |
| Gift of Life of Rotary District 7770 Inc | Human services | 501(c)(3) | 1998 | $5,988 | $276,318 | 2023-06 |
| Boldsky Foundation | Community improvement and capacity building | 501(c)(3) | 2024 | $4,804 | $165 | 2025-12 |
| Spanish America | Human services | 501(c)(3) | 2022 | $4,301 | $76,575 | 2025-08 |
| Jonathan Edward Irvin Foundation | Human services | 501(c)(3) | 2022 | $4,003 | $110,435 | 2025-12 |
| Joint Services Support Corporation | Human services | 501(c)(3) | 2012 | $2,900 | $14,937 | 2025-12 |
| Veterans Chow Haul Inc | Food, agriculture and nutrition | 501(c)(3) | 2021 | $2,829 | $351 | 2025-12 |
| Spirit of South Carolina Inc | 501(c)(3) | 2016 | $2,502 | $3 million | 2025-12 | |
| RD Foundation | Animal-related | 501(c)(3) | 2023 | $1,274 | $672 | 2025-12 |
| Jim Shannon Memorial Foundation | Youth development | 501(c)(3) | 2021 | $1,204 | $29,300 | 2025-12 |
| Operation Heal Our Heroes Inc | Public and societal benefit | 501(c)(3) | 2020 | $1,125 | $83,506 | 2025-12 |
| Anglican Diocese of South Carolina Development Fund | Religion-related | 501(c)(3) | 2023 | $784 | $7,715 | 2025-12 |
| Hart Learning Academy Inc | Human services | 501(c)(3) | 2022 | $750 | $11,040 | 2025-12 |
| Empowering People in the Community-Epic | Community improvement and capacity building | 501(c)(3) | 2017 | $297 | $5,998 | 2025-12 |
| Center for A Better South | Civil rights, social action and advocacy | 501(c)(3) | 2007 | $56 | $3,240 | 2024-12 |
| 1 South Carolina Commandery | Mutual and membership benefit | 501(c)(10) | 2026 | |||
| 1913 the Death of Us Inc | Education | 501(c)(3) | 2025 | |||
| 942ND Trans Auxiliary | Public and societal benefit | 501(c)(3) | 2017 | $0 | $0 | 2023-12 |
| A Centralized Moment - the Focus Is You | Human services | 501(c)(3) | 2021 | $0 | $0 | 2024-12 |
| A Home for School | Education | 501(c)(3) | 2023 | $0 | $0 | 2024-12 |
| A Longer Table | Human services | 501(c)(3) | 2021 | $0 | $0 | 2024-12 |
By cause in Charleston, SC
- Education 149
- Religion-related 104
- Arts, culture and humanities 101
- Human services 99
- Philanthropy, voluntarism and grantmaking foundations 95
- Recreation and sports 73
- Community improvement and capacity building 70
- Health care 42
- Housing and shelter 28
- Environment 28
- Youth development 26
- Public and societal benefit 26
- Animal-related 23
- Mental health and crisis intervention 23
- Diseases, disorders and medical disciplines 16
- International, foreign affairs and national security 15
- Food, agriculture and nutrition 14
- Mutual and membership benefit 10
- Science and technology 9
- Medical research 9
- Employment 8
- Public safety, disaster preparedness and relief 8
- Civil rights, social action and advocacy 8
- Crime and legal-related 6
Nonprofits in every city of the state
Read from the IRS Exempt Organizations Business Master File, updated by the IRS on October 24, 2026 and rebuilt here every morning. Revenue and assets are from each organization's latest filing as the IRS lists it; the IRS record is the official one. Organizations only: no people are named on these pages.