Data / Nonprofits / Missouri
Nonprofits in Missouri: 44,280 registered with the IRS
44,280 nonprofits are registered with the IRS in Missouri, 35,245 of them 501(c)(3) charities; the 10,619 that report revenue took in $115.40 billion. The most are in Saint Louis (9,221), Kansas City (4,976), Springfield (1,491). The largest by revenue: BJC Health System ($11.25 billion), Government Employees Health Association Inc ($6.10 billion), Washington University ($5.90 billion).
SpecStream is the live web data engine for teams and agents. It reads the IRS register of exempt organizations as the IRS updates it, and this page is that reading. Ask for the nonprofits you need by place, cause and size, with their latest Form 990 figures and websites, and they arrive in your sheet, CRM, Slack or agent.
By cause
- Religion-related 3,938
- Education 3,412
- Human services 2,982
- Philanthropy, voluntarism and grantmaking foundations 2,707
- Arts, culture and humanities 2,118
- Recreation and sports 2,040
- Community improvement and capacity building 1,616
- Health care 1,029
- Youth development 872
- Animal-related 756
- Public and societal benefit 746
- Housing and shelter 627
- Mental health and crisis intervention 605
- Mutual and membership benefit 559
- Food, agriculture and nutrition 418
- Public safety, disaster preparedness and relief 399
- Environment 339
- Crime and legal-related 317
- Employment 310
- Diseases, disorders and medical disciplines 258
- International, foreign affairs and national security 248
- Civil rights, social action and advocacy 176
- Science and technology 98
- Medical research 89
- Social science 18
By city
- Saint Louis 9,221
- Kansas City 4,976
- Springfield 1,491
- Columbia 1,183
- Jefferson Cty 932
- Saint Charles 684
- St Louis 579
- Florissant 576
- Lees Summit 570
- Chesterfield 555
- Joplin 500
- Independence 491
- Saint Joseph 368
- Cpe Girardeau 313
- TWN and Cntry 276
- Branson 242
- Blue Springs 242
- Rolla 241
- Ballwin 230
- Wentzville 223
- Liberty 210
- Sedalia 205
- Poplar Bluff 202
- Fenton 198
- Saint Peters 190
- Clayton 189
- Kirksville 176
- Ozark 172
- Lebanon 171
- Ofallon 170
- West Plains 170
- Raytown 165
- Warrensburg 165
- Grandview 161
- Harrisonville 160
- Hannibal 160
- Nixa 157
- O Fallon 150
- Fulton 145
- Wildwood 143
- Chillicothe 142
- Sikeston 138
- Carthage 135
- Festus 134
- Washington 134
- Farmington 134
- Neosho 131
- Belton 129
- Mexico 129
- Kirkwood 127
- Maryland HTS 125
- Clinton 125
- Lake St Louis 123
- Bridgeton 121
- Bolivar 120
- Troy 117
- Moberly 117
- Jackson 113
- Platte City 113
- Perryville 111
- Union 110
- Manchester 105
- Hazelwood 105
- Maryville 104
- Marshall 103
- Arnold 102
- Boonville 101
- Eureka 97
- Nevada 97
- Raymore 95
- Jefferson City 94
- Kearney 93
- Smithville 92
- St Peters 91
- Marshfield 90
- Camdenton 89
- Trenton 87
- Hillsboro 86
- Ste Genevieve 85
- Imperial 84
- Ava 81
- Webster GRVS 80
- Salem 80
- Warrenton 80
- Parkville 79
- Dexter 78
- Odessa 77
- Monett 76
- Fredericktown 75
- Creve Coeur 75
- St Joseph 74
- Gladstone 73
- Webb City 73
- Sullivan 71
- Richmond 70
- Rogersville 70
- Cameron 70
- Macon 70
- Kennett 69
- Bowling Green 69
- Warsaw 68
- California 68
- Pleasant Hill 67
- High Ridge 65
- Republic 63
- Pacific 62
- Owensville 62
- Higginsville 62
- Saint James 61
- Hermann 61
- Excelsior SPG 60
- Bonne Terre 60
- Ellisville 59
- Doniphan 59
- Cassville 58
- Fayette 57
- Mount Vernon 57
- Grain Valley 57
- Ferguson 57
- Waynesville 55
- Buffalo 55
- Cuba 55
- Butler 55
- Eldon 54
- Aurora 54
- Oak Grove 54
- Park Hills 54
- N Kansas City 54
- Louisiana 54
- Carrollton 54
- De Soto 53
- Osage Beach 52
- University Cy 52
- Mountain GRV 52
- Lamar 50
- Potosi 50
- Peculiar 49
- Lexington 49
- Holden 48
- Centralia 48
- Hollister 48
- Ashland 47
- Montgomery Cy 47
- Brookfield 47
- Wright City 47
- Savannah 47
- Bethany 46
- Charleston 45
- Black Jack 44
- Lake Ozark 44
- Marceline 44
- Willard 44
- Kimberling Cy 44
- St Robert 43
- Dixon 43
- El Dorado SPG 43
- Carl Junction 43
- Valley Park 43
- House Springs 42
- Houston 42
- Saint Ann 42
- Saint Clair 42
- Seymour 40
- Weston 40
- Ironton 40
- Versailles 39
- Strafford 39
- Memphis 39
- New Haven 39
- Desoto 39
- Saint Robert 39
- Mountain View 38
- Stockton 38
- Ellington 38
- Palmyra 38
- Willow SPGS 38
- Licking 37
- Cottleville 37
- Osceola 37
- Richland 36
- Reeds Spring 35
- Des Peres 35
- Cabool 35
- Piedmont 35
- Paris 34
- Shell Knob 34
- Monroe City 34
- Forsyth 34
- Marble Hill 34
- Foristell 33
- Thayer 33
- Anderson 33
- Brentwood 33
- Canton 33
- Lawson 32
- St Charles 32
- Rock Port 32
- Crystal City 31
- Hallsville 31
- Cape Girardeau 31
- Olivette 31
- Princeton 30
- Tipton 30
- Shelbina 30
- Mansfield 30
- Albany 30
- Holts Summit 30
- Linn 30
- Weldon Spring 29
- Steelville 29
- Malden 29
- Cedar Hill 29
- Bourbon 28
- Vandalia 28
- Maplewood 28
- Barnhart 28
- Unionville 28
- Tarkio 28
- Gallatin 28
- Dardenne PR 28
- Lincoln 27
- Appleton City 27
- Windsor 27
- Lone Jack 27
- Pineville 27
- Branson West 27
- Kahoka 27
- Salisbury 27
- Marthasville 27
- Elsberry 27
- Fair Grove 27
- Cole Camp 27
- Gainesville 27
- Seneca 26
- Highlandville 26
- Overland 26
- Edina 26
- Sunrise Beach 26
- Plattsburg 26
- Grant City 25
- Belle 25
- Greenwood 25
- Concordia 25
- Milan 25
- Hayti 24
- Caruthersvlle 24
- Vienna 24
- New London 24
- Stanberry 24
- Hermitage 24
- Mound City 24
- Knob Noster 24
- Norborne 23
- Stover 23
- Jasper 23
- Villa Ridge 22
- Moscow Mills 22
- Lancaster 22
- Clever 22
- Fordland 22
- Linn Creek 22
- Richmond HTS 22
- Winfield 22
- Greenfield 22
- Ash Grove 22
- Crane 22
- Hartville 21
- Earth City 21
- Desloge 21
- Adrian 21
- Hamilton 21
- Bloomfield 21
- Iberia 21
- Conway 21
- Eminence 21
- Chaffee 21
- La Plata 21
- Maysville 21
- Noel 21
- Lathrop 20
- Battlefield 20
- Ft Leonard WD 20
- Gower 20
- Holt 20
- Kingsville 20
- Scott City 20
- Crocker 20
- Billings 20
- Marionville 20
- Gravois Mills 20
- New Madrid 20
- Glasgow 20
- Jennings 20
- Sweet Springs 20
- Riverside 19
- Summersville 19
- East Prairie 19
- Advance 19
- Defiance 18
- Walnut Shade 18
The 100 largest by revenue
| Organization | City | Category | Type | Since | Revenue | Assets | Filing |
|---|---|---|---|---|---|---|---|
| BJC Health System | Saint Louis | Health care | 501(c)(3) | 2002 | $11.25 billion | $7.98 billion | 2024-12 |
| Government Employees Health Association Inc | Lees Summit | 501(c)(9) | 1947 | $6.10 billion | $2.55 billion | 2024-12 | |
| Washington University | St Louis | Education | 501(c)(3) | 1933 | $5.90 billion | $22.33 billion | 2025-06 |
| Ascension Seton | Saint Louis | 501(c)(3) | 2009 | $3.32 billion | $3.39 billion | 2025-06 | |
| Ascension Health Alliance | Saint Louis | 501(c)(3) | 1946 | $3.28 billion | $22.16 billion | 2025-06 | |
| Childrens Mercy Hospital | Kansas City | Health care | 501(c)(3) | 1956 | $2.34 billion | $3.80 billion | 2025-06 |
| SSM Health Care St Louis | Saint Louis | Health care | 501(c)(3) | 1946 | $2.19 billion | $1.08 billion | 2024-12 |
| BJC Health System | Saint Louis | Health care | 501(c)(3) | 2002 | $2.04 billion | $7.79 billion | 2024-12 |
| Mercy Hospitals East Communities | Chesterfield | Health care | 501(c)(3) | 1946 | $1.97 billion | $935.6 million | 2025-06 |
| Lester E Cox Medical Center | Springfield | Health care | 501(c)(3) | 1944 | $1.96 billion | $2.11 billion | 2025-09 |
| Sacred Heart Health System Inc | Saint Louis | Health care | 501(c)(3) | 1946 | $1.85 billion | $939 million | 2025-06 |
| MHM Support Services | Chesterfield | 501(c)(3) | 1946 | $1.66 billion | $764.8 million | 2025-06 | |
| St Vincent Hospital & Health Care | Saint Louis | Health care | 501(c)(3) | 1946 | $1.66 billion | $1.25 billion | 2025-06 |
| Mercy Hospital Springfield | Springfield | Health care | 501(c)(3) | 1946 | $1.45 billion | $593.4 million | 2025-06 |
| SSM Health Care Corporation | Saint Louis | Health care | 501(c)(3) | 1946 | $1.39 billion | $7.02 billion | 2024-12 |
| Saint Thomas West Hospital | Saint Louis | Health care | 501(c)(3) | 1946 | $1.27 billion | $763.8 million | 2025-06 |
| St Louis University | Saint Louis | Education | 501(c)(3) | 1946 | $1.20 billion | $3.05 billion | 2025-06 |
| SSM Health Care of Oklahoma Inc | Saint Louis | Health care | 501(c)(3) | 1946 | $1.12 billion | $453.7 million | 2024-12 |
| Ascension Health-Is Inc | Saint Louis | 501(c)(3) | 1946 | $989.7 million | $739.1 million | 2025-06 | |
| Ssm-Sluh Inc | Saint Louis | 501(c)(3) | 1946 | $947.9 million | $708.1 million | 2024-12 | |
| Truman Medical Center Incorporated | Kansas City | Health care | 501(c)(3) | 1986 | $892 million | $533.6 million | 2025-06 |
| Heartland Regional Medical Center | Saint Joseph | Health care | 501(c)(3) | 1937 | $883.4 million | $582.4 million | 2025-06 |
| Ascension Via Christi Hospitals Wichita Inc | Saint Louis | Health care | 501(c)(3) | $844.6 million | $391 million | 2025-06 | |
| Delta Dental of Missouri | St Louis | 501(c)(4) | 1972 | $805.5 million | $229.1 million | 2024-12 | |
| Mercy Clinic East Communities | Chesterfield | 501(c)(3) | 1999 | $804.6 million | $160.4 million | 2025-06 | |
| Greater Kansas City Community Foundation | Kansas City | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 1979 | $781.8 million | $3.39 billion | 2024-12 |
| SSM Health Care of Wisconsin Inc | Saint Louis | Health care | 501(c)(3) | 1946 | $770.2 million | $499.4 million | 2024-12 |
| Saint Francis Medical Center | Cpe Girardeau | Health care | 501(c)(3) | 1946 | $767.2 million | $1.15 billion | 2025-06 |
| Greater Horizons | Kansas City | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 2009 | $754.1 million | $2.78 billion | 2024-12 |
| Columbia St Marys Hospital Milwaukee Inc | Saint Louis | Health care | 501(c)(3) | 1946 | $724 million | $455.9 million | 2025-06 |
| Freeman Health System | Joplin | Health care | 501(c)(3) | 1995 | $709.6 million | $734.7 million | 2025-03 |
| Mercy Hospital South | Saint Louis | Health care | 501(c)(3) | 1996 | $709.1 million | $539.4 million | 2025-06 |
| St Lukes Episcopal-Presbyterian Hospital | Chesterfield | Health care | 501(c)(3) | 1953 | $685.5 million | $882.9 million | 2025-06 |
| St Marys Health Inc Dba Ascension | Saint Louis | Health care | 501(c)(3) | 1946 | $669.3 million | $369.9 million | 2025-06 |
| Compass Health Inc | Clinton | Mental health and crisis intervention | 501(c)(3) | 1975 | $663.5 million | $456.6 million | 2025-06 |
| Agnesian Healthcare Inc | Saint Louis | Health care | 501(c)(3) | 1946 | $584.4 million | $743.4 million | 2024-12 |
| Mercy Clinic Springfield Communities | Chesterfield | Health care | 501(c)(3) | 1946 | $570.8 million | $36.1 million | 2025-06 |
| Presence Chicago Hospitals Network | Saint Louis | Human services | 501(c)(3) | 1943 | $562.3 million | $293 million | 2025-06 |
| St Agnes Healthcare Inc | Saint Louis | Health care | 501(c)(3) | 1946 | $536.7 million | $364.5 million | 2025-06 |
| Saint Thomas Rutherford Hospital | Saint Louis | Health care | 501(c)(3) | 1946 | $519.8 million | $434.5 million | 2025-06 |
| St Vincents Medical Center Inc | Saint Louis | 501(c)(3) | 1946 | $493 million | $312.6 million | 2025-06 | |
| Beacon Kalamazoo Inc | Saint Louis | Health care | 501(c)(3) | 2026 | $486.2 million | $220.6 million | 2025-06 |
| Alexian Brothers Medical Center | Saint Louis | Health care | 501(c)(3) | 1946 | $475.1 million | $323.3 million | 2025-06 |
| SSM Cardinal Glennon Childrens Hospital | Saint Louis | Health care | 501(c)(3) | 1946 | $441.3 million | $602.9 million | 2024-12 |
| CH Allied Services Inc | Columbia | Health care | 501(c)(3) | 2020 | $438.3 million | $238 million | 2024-12 |
| Southeast Hospital | Cpe Girardeau | Health care | 501(c)(3) | 1929 | $404.5 million | $195.6 million | 2025-06 |
| Ascension Se Wisconsin Hospital Inc | Saint Louis | Health care | 501(c)(3) | 1946 | $400.5 million | $277.7 million | 2025-06 |
| Coxhealth | Springfield | Health care | 501(c)(3) | 2015 | $394.6 million | $1.98 billion | 2025-09 |
| St Alexius Medical Center | Saint Louis | Health care | 501(c)(3) | 1946 | $389.3 million | $244.3 million | 2025-06 |
| Ascension Health | Saint Louis | Health care | 501(c)(3) | 1946 | $383.1 million | $2.17 billion | 2025-06 |
| Saint Thomas Medical Partners | Saint Louis | Health care | 501(c)(3) | 1997 | $366.2 million | $125.3 million | 2025-06 |
| Ascension Providence | Saint Louis | Health care | 501(c)(3) | 1946 | $357.5 million | $206.1 million | 2025-06 |
| St Lukes - St Vincents Healthcareinc | Saint Louis | Health care | 501(c)(3) | 1946 | $355.2 million | $210 million | 2025-06 |
| Ascension All Saints Hospital Inc | Saint Louis | Health care | 501(c)(3) | 1946 | $355 million | $271.1 million | 2025-06 |
| SSM Health Care Group | Saint Louis | Health care | 501(c)(3) | 2022 | $351.9 million | $175.8 million | 2024-12 |
| Missouri Valley Line Constructors | Kansas City | 501(c)(6) | 1958 | $350.7 million | $3 million | 2024-12 | |
| Mercy Hospital Joplin | Joplin | Health care | 501(c)(3) | 1946 | $342.6 million | $181.4 million | 2025-06 |
| St Vincent Medical Group Inc | Saint Louis | 501(c)(3) | 1946 | $338.6 million | $158.4 million | 2025-06 | |
| Hannibal Regional Healthcare System Inc | Hannibal | Health care | 501(c)(3) | 1987 | $325.4 million | $219.1 million | 2025-09 |
| Skaggs Community Hospital Association | Branson | Health care | 501(c)(3) | 1948 | $315 million | $393 million | 2025-09 |
| Mercy Health | Chesterfield | Health care | 501(c)(3) | 1946 | $310.4 million | $4.82 billion | 2025-06 |
| National Electrical Contractors Association Inc | Kansas City | 501(c)(6) | 1965 | $306.7 million | $4.7 million | 2024-12 | |
| Mercy Hospital Jefferson | Crystal City | Health care | 501(c)(3) | 1958 | $300.2 million | $237.4 million | 2025-06 |
| St Vincent Carmel Hospital Inc | Saint Louis | 501(c)(3) | 1946 | $290.9 million | $167.6 million | 2025-06 | |
| Ascension Health Professional and General Liability Self-Insurance | Saint Louis | Mutual and membership benefit | 501(c)(3) | 2006 | $286 million | $711.6 million | 2025-06 |
| Concordia Health Plan | Saint Louis | 501(c)(9) | 1966 | $285.8 million | $215.8 million | 2024-12 | |
| Seton Family of Doctors | Saint Louis | Health care | 501(c)(3) | 2014 | $284.3 million | $207.3 million | 2025-06 |
| SSM Health Businesses | Saint Louis | Health care | 501(c)(3) | 1946 | $273.9 million | $284.6 million | 2024-12 |
| Lake Regional Health System | Osage Beach | Health care | 501(c)(3) | 1974 | $273.5 million | $269 million | 2025-04 |
| Central Electric Power Cooperative | Jefferson Cty | 501(c)(12) | 1957 | $269.6 million | $560 million | 2024-12 | |
| Good Samaritan Regional Health Center | Saint Louis | Health care | 501(c)(3) | 1999 | $264.5 million | $169.9 million | 2024-12 |
| Fellowship of Christian Athletes | Kansas City | Youth development | 501(c)(3) | 1956 | $262.4 million | $174.6 million | 2025-08 |
| Stifel Charitable Inc | Saint Louis | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 2019 | $261.5 million | $733.3 million | 2025-12 |
| Ozarks Medical Center | West Plains | Health care | 501(c)(3) | 1960 | $261.4 million | $195 million | 2024-12 |
| Burrell Inc | Springfield | 501(c)(3) | 1976 | $260.3 million | $257 million | 2025-06 | |
| Presence St Marys Hospital Presence Central and Suburban Hospitals Net | Saint Louis | Health care | 501(c)(3) | 1946 | $256 million | $161.2 million | 2025-06 |
| Lutheran Senior Services | Saint Louis | Human services | 501(c)(3) | 1946 | $254.5 million | $898.9 million | 2024-12 |
| Mers Missouri Goodwill Industries | Saint Louis | Human services | 501(c)(3) | 1938 | $251.7 million | $177.3 million | 2024-12 |
| A T Still University of Health Sciences | Kirksville | Education | 501(c)(3) | 1943 | $238.5 million | $600.6 million | 2025-06 |
| The Monroe Clinic Inc | Saint Louis | Health care | 501(c)(3) | 1946 | $237.1 million | $310.4 million | 2024-12 |
| Ascension Medical Group-Southeast Wisconsin Inc | Saint Louis | Health care | 501(c)(3) | 1946 | $235.8 million | $64.8 million | 2025-06 |
| Missouri Chamber Federation Benefit Plan Trust | Jefferson Cty | Mutual and membership benefit | 501(c)(9) | 2019 | $228.5 million | $24.5 million | 2024-12 |
| Mercy Clinic Oklahoma Communities | Chesterfield | Health care | 501(c)(3) | 2014 | $225.7 million | $39.1 million | 2025-06 |
| Saint Francis Healthcare System | Cpe Girardeau | Health care | 501(c)(3) | 1995 | $215.9 million | $871.3 million | 2025-06 |
| University Health Physicians | Kansas City | Health care | 501(c)(3) | 1984 | $214.2 million | $45.2 million | 2025-06 |
| Cox Health Systems Insurance Company | Springfield | Health care | 501(c)(4) | 2015 | $211.8 million | $62.8 million | 2024-12 |
| Dell Childrens Medical Group | Saint Louis | Health care | 501(c)(3) | 2014 | $208.3 million | $38.9 million | 2025-06 |
| St Anthony Shawnee Hospital Inc | Saint Louis | Health care | 501(c)(3) | 1946 | $205.5 million | $146.6 million | 2024-12 |
| Ascension Health Texas | Saint Louis | Health care | 501(c)(3) | 1946 | $202.8 million | $110.1 million | 2025-06 |
| Stowers Resource Management Inc | Kansas City | Diseases, disorders and medical disciplines | 501(c)(3) | 2006 | $198.3 million | $2.06 billion | 2025-06 |
| St Vincent Anderson Regional Hospital Inc | Saint Louis | Health care | 501(c)(3) | 1946 | $192.6 million | $92.4 million | 2025-06 |
| Ascension Welfare Benefits Trust | Saint Louis | Mutual and membership benefit | 501(c)(9) | 2001 | $191.4 million | $172.4 million | 2024-12 |
| Missouri Delta Medical Center | Sikeston | Health care | 501(c)(3) | 1951 | $188.6 million | $99.4 million | 2025-09 |
| Ascension Wisconsin Inc | Saint Louis | Health care | 501(c)(3) | 2001 | $183.1 million | $229.7 million | 2025-06 |
| Citizens Electric Corporation | Perryville | 501(c)(12) | 1953 | $175.3 million | $377.1 million | 2025-12 | |
| Maryville University of St Louis | Saint Louis | Education | 501(c)(3) | 1980 | $171.7 million | $286.7 million | 2025-05 |
| St Vincents Health System Inc | Saint Louis | Health care | 501(c)(3) | 1946 | $168.7 million | $231.8 million | 2025-06 |
| Johnny Morris Ozarks Heritage Preserve | Springfield | Animal-related | 501(c)(3) | 2019 | $168 million | $516.2 million | 2024-12 |
| Webster University | Saint Louis | Education | 501(c)(3) | 1970 | $166.6 million | $284 million | 2025-05 |
| Kansas City University | Kansas City | Education | 501(c)(3) | 1947 | $165.5 million | $542 million | 2025-06 |
Read from the IRS Exempt Organizations Business Master File, updated by the IRS on October 24, 2026 and rebuilt here every morning. Revenue and assets are from each organization's latest filing as the IRS lists it; the IRS record is the official one. Organizations only: no people are named on these pages.