| Washington University | Education | 501(c)(3) | 1933 | $5.90 billion | $22.33 billion | 2025-06 |
| Delta Dental of Missouri | | 501(c)(4) | 1972 | $805.5 million | $229.1 million | 2024-12 |
| Mid-America Transplant Services | Health care | 501(c)(3) | 1975 | $108.1 million | $133.5 million | 2024-12 |
| Bethesda Long Term Care Inc | Health care | 501(c)(3) | 1983 | $43.9 million | $45.9 million | 2025-06 |
| Area Resources for Community and Human Services | Human services | 501(c)(3) | 1998 | $34.4 million | $11.7 million | 2025-06 |
| American Optometric Association Inc | | 501(c)(6) | 1936 | $29.6 million | $42.4 million | 2024-12 |
| Bethesda Senior Living Inc | Housing and shelter | 501(c)(3) | 1993 | $27.1 million | $57.5 million | 2025-06 |
| American Association of Orthodontists | | 501(c)(6) | 1942 | $25 million | $35 million | 2025-05 |
| The Opportunity Trust | Education | 501(c)(3) | 2017 | $21.6 million | $4 million | 2025-06 |
| Biostl | Education | 501(c)(3) | 2011 | $17.8 million | $19.1 million | 2024-12 |
| Regional Cultural & Performing Arts Development Commission | Arts, culture and humanities | 501(c)(3) | 1985 | $15 million | $9.2 million | 2024-12 |
| Employee Benefit Trust for Retirees of Spire Missouri Inc Covered By A | | 501(c)(9) | 1995 | $14.4 million | $193.4 million | 2025-09 |
| Justine Petersen Housing and Reinvestment Corporation | Housing and shelter | 501(c)(3) | 1998 | $14 million | $86.3 million | 2024-12 |
| Boy Scouts of America | | 501(c)(3) | 1965 | $14 million | $39.6 million | 2025-12 |
| Private Education-Employers Trust | | 501(c)(9) | 1994 | $13.2 million | $286,286 | 2025-06 |
| Sherwood Forest Camp Inc | Youth development | 501(c)(3) | 1942 | $10.4 million | $9.8 million | 2025-12 |
| Bethesda Health Group Inc | Human services | 501(c)(3) | 1934 | $9.2 million | $26.1 million | 2025-06 |
| Biogenerator | Science and technology | 501(c)(3) | 2003 | $8.7 million | $14 million | 2024-12 |
| Fontbonne University | Education | 501(c)(3) | 1946 | $8.1 million | $14.7 million | 2025-06 |
| Barnard Free Skin and Cancer Hospital | Health care | 501(c)(3) | 1934 | $6.3 million | $48.7 million | 2025-06 |
| Child Day Care Association of Saint Louis | Human services | 501(c)(3) | 1971 | $6.2 million | $1.7 million | 2025-12 |
| Spire Missouri Inc Benefit Plan Trust Veba for Certain Non-Union E | | 501(c)(9) | 1995 | $5.9 million | $48.4 million | 2025-09 |
| Alabama Gas Corporation Retired Hourly Employee Benefit Plans Trust | | 501(c)(9) | 1994 | $5.8 million | $63.1 million | 2025-12 |
| Fund for Israels Tomorrow | International, foreign affairs and national security | 501(c)(3) | 2010 | $5.2 million | $2.2 million | 2024-12 |
| St Louis Youth Soccer Association | | 501(c)(3) | 1977 | $4.8 million | $7 million | 2025-07 |
| Associated General Contractors of Missouri | | 501(c)(6) | 1951 | $4.8 million | $3.5 million | 2024-12 |
| National Council of Jewish Women St Louis Section | Human services | 501(c)(3) | 2026 | $4.7 million | $10.2 million | 2025-06 |
| Optometry Cares-The Aoa Foundation | Human services | 501(c)(3) | 2005 | $4.7 million | $4.3 million | 2024-12 |
| Lutheran Family and Childrens Services Foundation Inc | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 1998 | $4.4 million | $21.8 million | 2024-12 |
| Boy Scouts of America | Youth development | 501(c)(3) | 1965 | $4.4 million | $71.4 million | 2025-12 |
| Bethesda Services Inc | Health care | 501(c)(3) | 2000 | $4.3 million | $459,711 | 2025-06 |
| Delmar Divine Charitable Foundation | Community improvement and capacity building | 501(c)(3) | 2018 | $4 million | $20.2 million | 2025-12 |
| Alabama Gas Corporation Retired Salaried Employee Benefit Plans Trust | International, foreign affairs and national security | 501(c)(9) | 2014 | $3.3 million | $36.7 million | 2025-12 |
| St Louis Shakespeare Festival | Arts, culture and humanities | 501(c)(3) | 1999 | $3.3 million | $2.3 million | 2025-09 |
| Bethesda Health Group Foundation of St Louis Inc | Health care | 501(c)(3) | 1983 | $3.3 million | $86.7 million | 2025-06 |
| Chads Coalition for Mental Health | Mental health and crisis intervention | 501(c)(3) | 2005 | $3.2 million | $1.6 million | 2025-06 |
| St Louis Construction Training and Advancement Foundation | | 501(c)(6) | 1965 | $3.2 million | $6.1 million | 2024-12 |
| American Association of Orthodontists Foundation | Health care | 501(c)(3) | 1965 | $3.1 million | $42.2 million | 2025-07 |
| National Electrical Contractors Association Inc St Louis | | 501(c)(6) | 1944 | $2.6 million | $6.1 million | 2025-12 |
| Mechanical Contractors Association of Eastern Missouri Inc | Community improvement and capacity building | 501(c)(6) | 2011 | $2.5 million | $5.7 million | 2024-12 |
| Erise Williams and Associates Inc | Diseases, disorders and medical disciplines | 501(c)(3) | 2003 | $2.4 million | $2.1 million | 2024-12 |
| National Agricultural Genotyping Center Inc | Mutual and membership benefit | 501(c)(5) | 2014 | $2.3 million | $1.7 million | 2025-09 |
| Sherwood Forest Foundation | Arts, culture and humanities | 501(c)(3) | 2019 | $2.2 million | $12,449 | 2025-12 |
| Autonomous Case Management of St Louis | Human services | 501(c)(3) | 2003 | $2.1 million | $8.1 million | 2025-06 |
| Technical Assistance Corp | Community improvement and capacity building | 501(c)(3) | 1995 | $1.9 million | $12.6 million | 2024-12 |
| Birthright Counseling St Louis | Civil rights, social action and advocacy | 501(c)(3) | 1973 | $1.7 million | $5.4 million | 2024-12 |
| Ypo Inc | | 501(c)(6) | 1989 | $1.6 million | $987,294 | 2025-06 |
| Unity Foundation NP | Science and technology | 501(c)(3) | 2026 | $1.5 million | $54,672 | 2024-12 |
| STL Youth Jobs | Youth development | 501(c)(3) | 2019 | $1.5 million | $561,066 | 2025-03 |
| Southern Union Veba | | 501(c)(9) | 1991 | $1.4 million | $6.6 million | 2025-09 |
| Missouri Budget Project | Human services | 501(c)(3) | 2003 | $1.4 million | $1.2 million | 2024-12 |
| The Genome Partnership Inc | Community improvement and capacity building | 501(c)(6) | 2000 | $1.2 million | $28.5 million | 2025-06 |
| Christian Hospital Foundation | Health care | 501(c)(3) | 2003 | $1.1 million | $6.3 million | 2024-12 |
| Cyberup | Science and technology | 501(c)(3) | 2016 | $1.1 million | $815,746 | 2025-12 |
| Booth Manor of St Louis Inc | Health care | 501(c)(3) | 1998 | $1.1 million | $3.2 million | 2025-09 |
| Retired Salaried Employee Group Insurance Plan Trust | International, foreign affairs and national security | 501(c)(9) | 2014 | $1 million | $15.6 million | 2025-12 |
| Anheuser-Bush Brewery Conference Supplemental Unemployment Benf Fu | | 501(c)(9) | 1982 | $998,423 | $12.2 million | 2025-02 |
| Bnei Baruch America Inc | Religion-related | 501(c)(3) | 2012 | $965,798 | $2 million | 2024-12 |
| Centennial Housing Corp | Housing and shelter | 501(c)(3) | 2016 | $914,922 | $1.6 million | 2025-06 |
| St Louis Christian Medical Center Inc | | 501(c)(3) | 1974 | $861,872 | $3.5 million | 2025-09 |
| Hylton Point Apartments Inc | Housing and shelter | 501(c)(3) | 2016 | $781,234 | $1.8 million | 2025-06 |
| Friendly Academy | Education | 501(c)(3) | 2024 | $746,649 | $237,636 | 2025-06 |
| Inland Rivers Ports and Terminals Inc | | 501(c)(6) | 1975 | $736,639 | $548,528 | 2024-12 |
| American Optometric Student Association Incorporated | | 501(c)(6) | 1976 | $691,619 | $1.4 million | 2024-12 |
| East Loop Community Improvement District | Community improvement and capacity building | 501(c)(3) | 2018 | $683,410 | $560,210 | 2025-06 |
| Hylton Point Apartments II Inc | | 501(c)(3) | 2016 | $650,590 | $2.1 million | 2025-06 |
| United Brotherhood of Carpenters and Joiners of America Lu 97 | | 501(c)(5) | 1940 | $625,711 | $2 million | 2026-06 |
| Oxbow Crossing and River Landing Public Improvement Company | Community improvement and capacity building | 501(c)(6) | 2020 | $618,577 | $62,589 | 2025-12 |
| St Louis Aquarium at Union Station Foundation | Animal-related | 501(c)(3) | 2019 | $579,585 | $2 million | 2024-12 |
| Community Builders Network of Metro St Louis | Community improvement and capacity building | 501(c)(3) | 2014 | $567,021 | $301,166 | 2024-12 |
| Chamber Music Society of St Louis Inc | Arts, culture and humanities | 501(c)(3) | 2020 | $547,398 | $530,341 | 2025-06 |
| Solea Water | Food, agriculture and nutrition | 501(c)(3) | 2013 | $537,446 | $329,271 | 2024-12 |
| Gifted Resource Council | Education | 501(c)(3) | 1983 | $496,723 | $372,472 | 2024-12 |
| American Board of Optometry | Education | 501(c)(6) | 2010 | $495,928 | $590,567 | 2024-12 |
| Health and Homes St Louis | Community improvement and capacity building | 501(c)(3) | 2017 | $464,003 | $1.2 million | 2025-06 |
| United Brotherhood of Carpenters & Joiners of America 1310 Carpet La | | 501(c)(5) | 1953 | $441,312 | $278,402 | 2026-06 |
| Esco Technologies Foundation | Education | 501(c)(3) | 2006 | $426,961 | $509,861 | 2025-09 |
| Philanthropy Missouri | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 1971 | $390,208 | $424,785 | 2024-12 |
| International Association of Bridge & Structural Iron Workers District | | 501(c)(5) | 1956 | $389,238 | $672,024 | 2025-06 |
| Stepping Into the Light Inc | Religion-related | 501(c)(3) | 1996 | $380,950 | $0 | 2025-12 |
| Black Girls Do Stem | Education | 501(c)(3) | 2019 | $349,737 | $428,562 | 2025-12 |
| St Louis Housing and Service Corp | | 501(c)(3) | | $321,466 | $32,015 | 2011-12 |
| Ignite Theatre Company | Arts, culture and humanities | 501(c)(3) | 2015 | $317,252 | $4,841 | 2024-12 |
| Litshop | Education | 501(c)(3) | 2019 | $309,466 | $158,355 | 2025-12 |
| Barnes Jewish Hospital Medical Staff Association | | 501(c)(6) | 1997 | $299,785 | $484,968 | 2025-12 |
| Southwest Mortgagee Advisory Council Inc | Community improvement and capacity building | 501(c)(6) | 2006 | $290,730 | $102,650 | 2024-12 |
| St Louis Altenheim | | 501(c)(3) | 1940 | $290,304 | $4.6 million | 2024-12 |
| American Federation of Government Employees | | 501(c)(5) | 1940 | $248,058 | $385,617 | 2025-12 |
| Christian Board of Publication | | 501(c)(3) | 1951 | $240,990 | $1.3 million | 2025-12 |
| United Brotherhood of Carpenters & Joiners of America | | 501(c)(5) | 1970 | $228,360 | $118,444 | 2026-06 |
| Missouri Hockey Inc | Recreation and sports | 501(c)(3) | 1992 | $219,153 | $855,007 | 2026-05 |
| Cherokee Events | Arts, culture and humanities | 501(c)(3) | 2020 | $212,758 | $66,918 | 2025-12 |
| Shriners International | | 501(c)(10) | 1949 | $205,816 | $386,164 | 2022-12 |
| Little Urban Smiles Inc | Health care | 501(c)(3) | 2015 | $197,502 | $55,969 | 2025-12 |
| Women of Achievement | Community improvement and capacity building | 501(c)(3) | 1994 | $195,814 | $251,262 | 2025-09 |
| St Louis Rotary Club Welfare Fund Inc | | 501(c)(3) | 1949 | $192,763 | $160,156 | 2025-06 |
| Very Asian Foundation | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 2022 | $151,774 | $113,715 | 2024-12 |
| Rotary International | | 501(c)(4) | 1937 | $136,049 | $67,030 | 2025-06 |
| Delmar Divine Support Corporation | Community improvement and capacity building | 501(c)(3) | 2018 | $131,406 | $10.7 million | 2025-12 |
| Missouri Women in Trades | Employment | 501(c)(3) | 2016 | $129,618 | $32,684 | 2025-06 |
| Joes Place Corporation | Human services | 501(c)(3) | 2014 | $124,798 | $215,431 | 2025-12 |
| Techartista Foundation | Arts, culture and humanities | 501(c)(3) | 2022 | $114,531 | $10,944 | 2024-12 |
| Asian American Chamber of Commerce Aacc of St Louis | Community improvement and capacity building | 501(c)(6) | 2015 | $114,125 | $197,839 | 2024-12 |
| Books for Newborns Inc | Education | 501(c)(3) | 2016 | $110,574 | $296,771 | 2024-12 |
| St Louis Carpenters District Council Scholarship Fund Inc | Education | 501(c)(3) | 1999 | $105,799 | $478,040 | 2025-06 |
| Spire Gulf Inc | | 501(c)(9) | 1992 | $93,256 | $5.2 million | 2025-12 |
| Missouri Pacific Historical Society | Arts, culture and humanities | 501(c)(3) | 1982 | $86,428 | $308,100 | 2024-12 |
| University of Missouri at St Louis Alumni Association | Education | 501(c)(3) | 1968 | $85,273 | $506,346 | 2025-06 |
| The African Heritage Association of St Louis Inc | Arts, culture and humanities | 501(c)(3) | 1995 | $80,761 | $59,016 | 2025-06 |
| National Tool Die & Precision Machining Association Greater St Louis CH | | 501(c)(6) | 1969 | $80,221 | $281,969 | 2025-09 |
| Buttons & Bows Preschool Development Center Inc | | 501(c)(3) | 1981 | $78,666 | $720,826 | 2024-12 |
| Allegro - A St Louis Choral Community | Arts, culture and humanities | 501(c)(3) | 2021 | $75,620 | $46,644 | 2025-12 |
| McAuley Counseling Services Inc | Human services | 501(c)(3) | 2001 | $74,844 | $656,442 | 2025-12 |
| The Bingham Trust | Arts, culture and humanities | 501(c)(3) | 2019 | $73,458 | $3.6 million | 2024-12 |
| Black Catholic Messenger Foundation | Religion-related | 501(c)(3) | 2021 | $64,904 | $8,782 | 2025-12 |
| Round Table | | 501(c)(7) | 1964 | $60,058 | $73,618 | 2025-06 |
| Mobile Gas Service Corporation Employee Benefit Trust | | 501(c)(9) | 1992 | $54,751 | $2.8 million | 2025-12 |
| Jerry McDowell Memorial Scholarship Foundation | Education | 501(c)(3) | 2008 | $48,493 | $86,069 | 2025-12 |
| Institute for Theological Encounter With Science & Technology Inc | | 501(c)(3) | 1946 | $44,461 | $12,993 | 2025-12 |
| Pro Bono Advisory Council | Public and societal benefit | 501(c)(3) | 2016 | $35,340 | $46,140 | 2025-09 |
| Dante Society of America Inc Boylston Hall | | 501(c)(3) | 1957 | $30,852 | $441,391 | 2024-12 |
| The Health Goes Global Foundation | International, foreign affairs and national security | 501(c)(3) | 2014 | $28,455 | $56,369 | 2024-12 |
| JVL Housing Corp | | 501(c)(3) | 1974 | $11,678 | $261,952 | 2024-12 |
| By Empowerment Solutions | Human services | 501(c)(3) | 2025 | $7,293 | $4,167 | 2025-12 |
| Ville Community Development Foundation - St Louis | Human services | 501(c)(3) | 2019 | $620 | $1,337 | 2025-12 |
| St Louis Area Regional Response System Starrs | Public safety, disaster preparedness and relief | 501(c)(3) | 2003 | $200 | $67,719 | 2025-12 |
| 9-11 Memorial March To the Arch | Public and societal benefit | 501(c)(3) | 2014 | $0 | $0 | 2025-12 |
| Abstrakt Arts Foundation | Human services | 501(c)(3) | 2024 | $0 | $0 | 2024-12 |
| Abundant Fellowship Church of God | Religion-related | 501(c)(3) | 2002 | | | |
| Abundant Grace Evangelistic Church | Religion-related | 501(c)(3) | 2003 | | | |
| Agc of St Louis Education Foundation | Education | 501(c)(3) | 1999 | | $1.2 million | 2024-12 |
| All About Education NP Inc | Education | 501(c)(3) | 2015 | $0 | $0 | 2025-12 |
| All Faith Baptist Church | | 501(c)(3) | 1978 | | | |
| All Faith Church Inc | Religion-related | 501(c)(3) | 2007 | | | |
| Alpha & Omega Life Church | Religion-related | 501(c)(3) | 2008 | | | |
| Ambassadors of Christ To Haiti Inc | Religion-related | 501(c)(3) | 2020 | | | |
| American Friends of the Mishkan Mus Eum of Art | Arts, culture and humanities | 501(c)(3) | 2026 | | | |
| American Islamic Montessori Association | Education | 501(c)(3) | 2018 | $0 | $0 | 2025-12 |
| American Society of Addiction Medicine Inc | Mental health and crisis intervention | 501(c)(3) | 1986 | $0 | $0 | 2025-12 |
| Amtgard Kingdom of Tal Dagore | Recreation and sports | 501(c)(3) | 2024 | | | |
| Angelic House of Prayer Church of God | | 501(c)(3) | 1988 | | | |
| Angelic Temple of Deliverance | | 501(c)(3) | 1979 | | | |
| Apostolic Bible Church Missionary Alliance Inc | | 501(c)(3) | 1979 | | | |
| Archangel Michael Russian Orthodox Church | | 501(c)(3) | 1972 | | | |
| Archdiocese of St Louis Central Purchasing Agency | | 501(c)(3) | 1946 | | | 2001-06 |
| Arnold Air Society-Silver Wings | | 501(c)(4) | 1965 | $0 | $0 | 2025-09 |
| Arthur R Thomas Charitable Trust | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 2025 | | $3.3 million | 2025-12 |
| Arthur and Helen Baer Charitable Foundation | | 501(c)(3) | 1985 | | $7.4 million | 2024-12 |
| Ashmay Charitable Corporation | Human services | 501(c)(3) | 2024 | $0 | $0 | 2025-12 |
| Asian American Chamber of Commerce of St Louis Foundation | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 2012 | $0 | $0 | 2025-12 |
| Assembly of Faith Church | Religion-related | 501(c)(3) | 2010 | | | |
| Assembly of Wisdom | Religion-related | 501(c)(3) | 1995 | | | |
| Association for Computing Machinery | Science and technology | 501(c)(3) | 1968 | | | |
| Association of Corporate Counsel | | 501(c)(6) | 1983 | | | |
| Association of Veterans Education Certifying Officials | Education | 501(c)(3) | 2003 | $0 | $0 | 2025-12 |
| August Bible Church | | 501(c)(3) | 1984 | | | |
| BRN Associates Inc | Religion-related | 501(c)(3) | 2014 | $0 | $0 | 2025-12 |
| Baptist Church of the Holy Communion | | 501(c)(3) | 1972 | | | |
| Baptist Hospital Foundation of Nashville Inc | | 501(c)(3) | 1989 | $0 | $1 | 2025-06 |
| Battlefield Christian Center | Religion-related | 501(c)(3) | 2006 | | | |
| Beautification and Preservation Fund | Environment | 501(c)(3) | 2019 | $0 | $0 | 2025-12 |
| Bel-Ridge Bible Chapel | | 501(c)(3) | 1964 | | | |
| Berkeley Foursquare Church | | 501(c)(3) | 1949 | | | |
| Bermuda Bible Hall | | 501(c)(3) | 1968 | | | |
| Beth Hamedrosh Hagodol Congregation | Religion-related | 501(c)(3) | 1995 | | | |
| Beth-El Baptist Church | | 501(c)(3) | 1965 | | | |
| Bethany New Life Missionary B Church | Religion-related | 501(c)(3) | 2006 | | | |
| Bethlehem Full Gospel Christian Church | | 501(c)(3) | 2002 | | | |
| Better Together - the Advantage Solutions Education Foundation | Education | 501(c)(3) | 2022 | | $491,639 | 2024-12 |
| Bible Chapel | | 501(c)(3) | 1952 | | | |
| Bible Revelation Ministries | Religion-related | 501(c)(3) | 2001 | | | |
| Bibleway Church of Our Lord Jesus Christ of the Apostolic Faith Inc | | 501(c)(3) | 1994 | | | |
| Black Leaders Advancing Community Change | Arts, culture and humanities | 501(c)(3) | 2021 | $0 | $1 | 2024-12 |
| Bland Family Foundation | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 2003 | | $3.3 million | 2025-11 |
| Botanical Heights Neighborhood Association | | 501(c)(3) | 1994 | $0 | $0 | 2025-12 |
| Bread of Life Fellowship Inc | | 501(c)(3) | 1986 | | | |
| Brighter Day Christian Ministry | Religion-related | 501(c)(3) | 1997 | | | |
| Burning Bush Missionary Baptist Church Inc | | 501(c)(3) | 1986 | | | |
| Butler Hill Church of Christ | | 501(c)(3) | 1984 | | | |
| Butterfly Beginnings My Journey My Destiny | Human services | 501(c)(3) | 2021 | $0 | $0 | 2025-12 |
| By Faith Believing and By Faith Receiving Ministries Inc of St Lou | Housing and shelter | 501(c)(3) | 1998 | | | |
| Capital City Corporation for Growth | Community improvement and capacity building | 501(c)(3) | 2026 | | | |
| Cardinal Ritter College Prep | | 501(c)(3) | 1946 | | | |
| Catholic Schools Assistance Fund | | 501(c)(3) | 1946 | | | |
| Cedar Park Health System LLC | | 501(c)(3) | 2026 | | | |
| Center for Pragmatic Buddhism | Religion-related | 501(c)(3) | 2010 | | | |
| Central Christian Church of St Louis | | 501(c)(3) | 1972 | | | |
| Cephas Christian Church | Religion-related | 501(c)(3) | 2009 | | | |
| Chi Alpha at University of Missouri--St Louis | | 501(c)(3) | 1964 | | | |
| Chief Cornerstone Church of Jesus | Religion-related | 501(c)(3) | 2005 | | | |
| Chiron Community Giving Foundation | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 2022 | | $224,473 | 2025-12 |
| Christ Chapel | | 501(c)(3) | 1982 | | | |
| Christ Fellowship Bible Church | | 501(c)(3) | 1964 | | | |
| Christ Fellowship Ministries | Religion-related | 501(c)(3) | 2007 | | | |
| Christian Care Fellowship | | 501(c)(3) | 1991 | | | |
| Christian Disciples of St Louis Inc | | 501(c)(3) | 1986 | | | |
| Christian Methodist Episcopal Church | | 501(c)(3) | 1980 | | | |
| Christian Ministries of St Louis Inc | | 501(c)(3) | 1993 | | | |
| Christian Servant M B Church | Religion-related | 501(c)(3) | 2001 | | | |
| Christian Survival Ministries Inc | Religion-related | 501(c)(3) | 2003 | | | |
| Church of Christ Blessed Hope | Religion-related | 501(c)(3) | 2002 | | | |
| Church of Christ of Affton | | 501(c)(3) | 1989 | | | |
| Church of God Our Father & Lord Jesus Christ | | 501(c)(3) | 1977 | | | |
| Church of God at Baden | Religion-related | 501(c)(3) | 1998 | | | |
| Church of God in Christ Jesus Foundation of Apostles and Prophet | | 501(c)(3) | 1976 | | | |
| Church of Jesus Christ | | 501(c)(3) | 1990 | | | |
| Church of Jesus Christ King of Kings Lord of Lords | Religion-related | 501(c)(3) | 2001 | | | |
| Church of the Holy Apostles of St Louis Missouri | | 501(c)(3) | 1978 | | | |
| Church of the Living God Temple 119 CWFF | | 501(c)(3) | 1965 | | | |
| Church of the Living God of St Louis | | 501(c)(3) | 1989 | | | |
| Church of the Messiah | | 501(c)(3) | 1991 | | | |
| Circle of Light Independent Spritualist Church Inc | Religion-related | 501(c)(3) | 2004 | | | |
| Club Gifted 1 | Education | 501(c)(3) | 2025 | | | |
| Collaborative Law Association | Employment | 501(c)(6) | 2003 | $0 | $0 | 2026-06 |
| Community Chapel True Church of the Living Gos | | 501(c)(3) | 1987 | | | |
| Community Christian Ministries | | 501(c)(3) | 1987 | | | |
| Concord Ame Church | | 501(c)(3) | 1983 | | | |
| Concordia International Foundation | | 501(c)(3) | 1941 | | | |
| Connected Points Consulting Inc | Community improvement and capacity building | 501(c)(3) | 2022 | $0 | $1 | 2024-06 |
| Constructreach Foundation | Religion-related | 501(c)(3) | 2013 | $0 | $0 | 2025-12 |
| Cornerstone Fellowship Inc | | 501(c)(3) | 1988 | | | |
| Corpus Christi St Lucy Parish | | 501(c)(3) | 1946 | | | |
| Covenant Christian Church | Religion-related | 501(c)(3) | 2002 | | | |
| Covenant Church | Religion-related | 501(c)(3) | 1996 | | | |
| Crestwood Christian Church | | 501(c)(3) | 1971 | | | |
| Cymica Shegog Pathways To Success | Youth development | 501(c)(3) | 2024 | | | |
| Damascus Community Church | Religion-related | 501(c)(3) | 2004 | | | |
| Daughters of Charity Foundation of St Louis | | 501(c)(3) | 1946 | | | |
| Deaconess Foundation | Religion-related | 501(c)(3) | 1980 | | | 1997-09 |
| Destiny Christian Center | Religion-related | 501(c)(3) | 2004 | | | |
| Dickerson Memorial Community Church and Barksdale-Reed Community Cente | | 501(c)(3) | 1975 | | | |
| Divine Favor Christian Assembly | Religion-related | 501(c)(3) | 2002 | | | |
| Divine Fellowship Heights Church | Religion-related | 501(c)(3) | 2004 | | | |
| Divine Revelation of Christ Church Inc | Religion-related | 501(c)(3) | 2004 | | | |
| Do Ngak Cho Ling Tibetan Buddhist Center | | 501(c)(3) | 1992 | | | |
| Doris Evelyn Seider Charitable Trust | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 1997 | | | |
| East Union Missionary Baptist Church | | 501(c)(3) | 1994 | | | |
| Eastern Star Missionary Baptist Church | | 501(c)(3) | 1970 | | | |
| Ecumenical Campus Ministry | Mutual and membership benefit | 501(c)(3) | 1995 | | | |
| Elvira H Jubel Foundation | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 2018 | | $1.8 million | 2024-12 |
| Emmanuel Temple Church of God | Religion-related | 501(c)(3) | 2002 | | | |
| Emmaus Bible Chapel Corporation | | 501(c)(3) | 1975 | | | |
| Endowment Fund Directors of Delmar Baptist Church | Religion-related | 501(c)(3) | 2012 | | | |
| Episcopal Church Women | | 501(c)(3) | 1971 | | | |
| Evangelical Association of Reformed and Congregational Christian Churc | Religion-related | 501(c)(3) | 1999 | | | |
| Evangelist Center Church of God in Christ | Religion-related | 501(c)(3) | 2002 | | | |
| Evergreen Full Gospel Church | | 501(c)(3) | 1991 | | | |
| Everlasting Life Missionary Baptist Church | Religion-related | 501(c)(3) | 2007 | | | |
| Fabric of Kindness | Human services | 501(c)(3) | 2024 | | | |
| Fahamme Temple of Lillani Ra | | 501(c)(3) | 1973 | | | |
| Faith Bible Baptist Church of St Louis Inc | Religion-related | 501(c)(3) | 1999 | | | |
| Faith Bible Church of St Louis Mo | | 501(c)(3) | 1989 | | | |
| Faith Healing Tabernacle | | 501(c)(3) | 1964 | | | |
| Faith Missionary Baptist Church | Religion-related | 501(c)(3) | 1996 | | | |
| Faith Paradise Temple | Religion-related | 501(c)(3) | 1998 | | | |
| Faith Place | Religion-related | 501(c)(3) | 2005 | | | |
| Faith Temple the Church of God in Christ Congregational | Religion-related | 501(c)(3) | 2006 | | | |
| Fellowship Temple | | 501(c)(3) | 1978 | | | |
| Fieldstone Farm Foundation Inc | Animal-related | 501(c)(3) | 1999 | $0 | $0 | 2025-12 |
| Fifth Baptist Church of the City of St Louis Mo | | 501(c)(3) | 1992 | | | |
| First Church Devine Non Denominational | | 501(c)(3) | 1971 | | | |
| First Community Baptist Church | | 501(c)(3) | 1976 | | | |
| First Faith Chapel Inc | | 501(c)(3) | 1982 | | | |
| Footsteps of Jesus Christ Apostles Doctrine Church Inc | Religion-related | 501(c)(3) | 1997 | | | |
| Fourth Christian Chapel of North St Louis County | | 501(c)(3) | 1972 | | | |
| Franciscan Missionary Union | | 501(c)(3) | 1993 | | | |
| Friends of Valhalla | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 2014 | $0 | $0 | 2024-12 |
| Friends of the Archbishop | | 501(c)(3) | 1946 | | | |
| Friends of the Family Inc | | 501(c)(3) | 1991 | | | |
| Friends of the Learning Center of South St Louis County Inc | Education | 501(c)(3) | 1996 | | | |
| Full Gospel Churches International | | 501(c)(3) | 1977 | | | |
| Full Gospel Outreach Mission | | 501(c)(3) | 1979 | | | |
| Gary D Hedrick Ministries Inc | | 501(c)(3) | 1987 | | | |
| Gateway 2 Nourishment Outreach Ministry | Religion-related | 501(c)(3) | 2025 | | $1 | 2025-12 |
| Gateway Bible Church | | 501(c)(3) | 1984 | | | |
| Gateway Bible Fellowship Church Inc | | 501(c)(3) | 1972 | | | |
| Gateway Career Services Association | Education | 501(c)(3) | 1992 | $0 | $0 | 2025-06 |
| Gateway Childrens Charity | Education | 501(c)(3) | 2015 | $0 | $0 | 2025-12 |
| Gathering Place | Religion-related | 501(c)(3) | 2002 | | | |
| Gethsemane Ministries Inc | | 501(c)(3) | 1991 | $0 | $0 | 2025-12 |
| Glad Tidings Bible College Inc | Religion-related | 501(c)(3) | 1995 | | | |
| Gladiator Boxing Team | Recreation and sports | 501(c)(3) | 2025 | $0 | $0 | 2025-12 |
| God Is Able House of Prayer Outreach Ministries | Religion-related | 501(c)(3) | 2004 | | | |
| Gods Divine Purpose for Your Life Ministry | Human services | 501(c)(3) | 2018 | $0 | $0 | 2025-12 |
| Gods House of Prayer for All & Counseling Center | | 501(c)(3) | 1993 | | | |
| Gods Ministerys Inc | Religion-related | 501(c)(3) | 1997 | | | |
| Gods Spirit Assembly of God | | 501(c)(3) | 1964 | | | |
| Good News Missionary Baptist Church | | 501(c)(3) | 1979 | | | |
| Good Shepherd of the Living God | Religion-related | 501(c)(3) | 1995 | | | |
| Grace Fellowship Church | | 501(c)(3) | 1994 | | | |
| Grace Mission Baptist Church No 2 | | 501(c)(3) | 1972 | | | |
| Greater Bread of Life Missionary Baptist Church | Religion-related | 501(c)(3) | 1998 | | | |
| Greater Cavalry Missionary Baptist Church | Religion-related | 501(c)(3) | 2006 | | | |
| Greater Outreach Evangelistic Center | | 501(c)(3) | 1986 | | | |
| Greater Paradise Baptist Church | | 501(c)(3) | 1988 | | | |
| Greater St Louis Babywearing Inc | Human services | 501(c)(3) | 2019 | $0 | $0 | 2025-12 |
| Greater St Louis Chapter Moaa Cares | Human services | 501(c)(3) | 2025 | $0 | $0 | 2025-12 |
| Greater St Lukes Missionary Baptist Church Inc | | 501(c)(3) | 1980 | | | |
| Greater St Mark Missionary Baptist Church | | 501(c)(3) | 1988 | | | |
| Harrison Avenue Missionary Baptist Church | Religion-related | 501(c)(3) | 2006 | | | |
| Hazelwood Bible Chapel | | 501(c)(3) | 1966 | | | |
| Heartland Gaelic Athletic Association | Recreation and sports | 501(c)(3) | 2024 | $0 | $0 | 2025-12 |
| Heavenly Bread Missionary Baptist Church | | 501(c)(3) | 1965 | | | |
| Higher Heights Christian Church Inc | Religion-related | 501(c)(3) | 2002 | | | |
| Historical Society of the United States Courts in the Eighth Circui | | 501(c)(3) | 1987 | $0 | $0 | 2024-06 |
| Historical Society of the United States Courts in the Eighth Circui | | 501(c)(3) | 1987 | $0 | $0 | 2024-06 |
| Historical Society of the United States Courts in the Eighth Circui | | 501(c)(3) | 1987 | $0 | $0 | 2024-06 |
| Historical Society of the United States Courts in the Eighth Circui | | 501(c)(3) | 1987 | $0 | $0 | 2024-06 |
| Historical Society of the United States Courts in the Eighth Circui | | 501(c)(3) | 1987 | $0 | $0 | 2024-06 |
| Historical Society of the United States Courts in the Eighth Circui | | 501(c)(3) | 1987 | $0 | $0 | 2024-06 |
| Historical Society of the United States Courts in the Eighth Circui | | 501(c)(3) | 1987 | $0 | $0 | 2024-06 |
| Historical Society of the United States Courts in the Eighth Circui | | 501(c)(3) | 1987 | $0 | $0 | 2024-06 |
| Historical Society of the United States Courts in the Eighth Circui | | 501(c)(3) | 1987 | $0 | $0 | 2024-06 |
| Historical Society of the Us Courts in the Eighth Circuit | | 501(c)(3) | 1987 | $0 | $0 | 2024-06 |
| Historical Society of the Us Courts in the Eighth Circuit | | 501(c)(3) | | $0 | $0 | 2024-06 |
| Historical Society of the Us Courts in the Eigth Circuit Court | | 501(c)(3) | 1987 | $0 | $0 | 2024-06 |
| Holy Family Parish | | 501(c)(3) | 1946 | | | |
| Holy Innocents Parish | | 501(c)(3) | 1946 | | | |
| Holy Sunrise Spiritual Church of the Apostolic Faith | | 501(c)(3) | 1965 | | | |
| Hope Assembly of God | | 501(c)(3) | 1946 | | | |
| Hotel Dieu Hospital | Health care | 501(c)(3) | 1946 | | | |
| House of Peace | Religion-related | 501(c)(3) | 2000 | | | |
| House of the Anointed Christian Assembly | Religion-related | 501(c)(3) | 1999 | | | |
| Huhn Family Charitable Foundation | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 2022 | | $1.5 million | 2025-12 |
| I Am That I Am Inc | | 501(c)(3) | 1981 | | | |
| Illuminating Engineering Society | | 501(c)(3) | 1991 | | | |
| Immaculate Conception St Henry Parish | | 501(c)(3) | 1946 | | | |
| Impact Group Charitable Foundation | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 2009 | | $2.6 million | 2024-12 |
| In His Image Ministries Inc | Religion-related | 501(c)(3) | 1998 | | | |
| Independent Assemblies of God | | 501(c)(3) | 1964 | | | |
| Inpower Institute Inc | Human services | 501(c)(3) | 2025 | | $74,396 | 2024-12 |
| International Christian Missions Church | Religion-related | 501(c)(3) | 2007 | | | |
| International Lutheran Laymens League | | 501(c)(3) | 1970 | | | |
| International Lutheran Laymens League | Religion-related | 501(c)(3) | 1970 | | | |
| International Society for Krishna Consciousness of St Louis Inc | | 501(c)(3) | 1982 | | | |
| Iron Crusaders | Religion-related | 501(c)(3) | 2025 | $0 | $0 | 2025-12 |
| Jca Charitable Foundation | Health care | 501(c)(3) | 2002 | | $7.5 million | 2025-12 |
| Jeff-Vander-Lou Inc | | 501(c)(4) | 1967 | $0 | $0 | 2025-12 |
| Jefferson County Catholic Church Real Estate Corporation | | 501(c)(3) | 1946 | | | |
| Jeremiah Call Christ Ministry Jeremiah Baptist Church | | 501(c)(3) | 2007 | | | |
| Jesus Is All Church of God Apostolic Inc | | 501(c)(3) | 1992 | | | |
| Jesus Loves You Ministries Inc | | 501(c)(3) | 1982 | | | |
| John Allan Love Charitable Foundation | | 501(c)(3) | 1966 | | $3.3 million | 2025-12 |
| Johnson Memorial Missionary Baptist Church | Religion-related | 501(c)(3) | 2001 | | | |
| Joshua Ministries Inc | Religion-related | 501(c)(3) | 2000 | | | |
| Kappa Kappa Gamma Fraternity Inc | | 501(c)(7) | 1945 | | | |
| Kehilat Etz Hayim | | 501(c)(3) | 1986 | | | |
| Kenneth Shepard Ministries | Religion-related | 501(c)(3) | 2025 | | | |
| Kilalo Rites of Passage | Human services | 501(c)(3) | 1999 | | | |
| Kingdom Destiny Fellowship International | Religion-related | 501(c)(3) | 2024 | | | |
| Knights of Columbus | | 501(c)(8) | 1940 | $0 | $0 | 2025-12 |
| Kossuth Church of God in Christ | | 501(c)(3) | 1969 | | | |
| Last Command Ministries | | 501(c)(3) | 1994 | | | |
| Laura Anderson Ministries | Religion-related | 501(c)(3) | 2004 | | | |
| Lela Louise Smith Foundation Dtdfebruary 19 2004 | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 2006 | | $53,437 | 2024-12 |
| Lemay Link Inc | Community improvement and capacity building | 501(c)(3) | 2021 | $0 | $0 | 2025-12 |
| Leonard & Maudena Barnes Endowment Trust | | 501(c)(3) | 1951 | | | |
| Liberty Christian Church of St Louis Inc | | 501(c)(3) | 1988 | | | |
| Lighthouse Free Methodist Church Chinese | | 501(c)(3) | 1958 | | | |
| Lighthouse Ministries | Religion-related | 501(c)(3) | 2002 | | | |
| Lindenwood Baptist Church Inc | | 501(c)(3) | 1965 | | | |
| Living Faith MCC | | 501(c)(3) | 1973 | | | |
| Living Word Christian Fellowship | | 501(c)(3) | 1984 | | | |
| Logos Gospel Assembly | Religion-related | 501(c)(3) | 2008 | | | |
| Love Outreach Victory Temple | | 501(c)(3) | 1987 | | | |
| Love Temple Ministry | Crime and legal-related | 501(c)(3) | 2020 | $0 | $0 | 2024-12 |
| Love in Action Messiahs Endtime Ministries | Religion-related | 501(c)(3) | 1994 | | | |
| Lsamp Alumni Group | Arts, culture and humanities | 501(c)(3) | 2021 | | $193 | 2025-12 |
| Lucky Dog Foundation | Human services | 501(c)(3) | 2012 | | $6,934 | 2024-12 |
| Lutheran Church Missouri Synod Foundation | | 501(c)(3) | 1941 | | | 2019-12 |
| Lutheran Reformation Hour | Religion-related | 501(c)(3) | 1971 | | | |
| MJM Ministry Inc | Mental health and crisis intervention | 501(c)(3) | 2023 | $0 | $0 | 2025-12 |
| Maplewood Bible Chapel | | 501(c)(3) | 1952 | | | |
| Maronite Outreach | | 501(c)(3) | 1946 | | | |
| Masjid at Taqwa Wa Jihad | Religion-related | 501(c)(3) | 1996 | | | |
| McFamily Charitable Foundation | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 1997 | | $92,222 | 2024-12 |
| Meditation Spiritual Temple of Christ Inc | | 501(c)(3) | 1984 | | | |
| Melvin Theater Community Center Inc | Youth development | 501(c)(3) | 2018 | $0 | $0 | 2025-12 |
| Midwestern Unitarian Universalist Conference | | 501(c)(3) | 1965 | | | |
| Missouri Commitee On Trauma | Health care | 501(c)(3) | 2015 | $0 | $0 | 2025-12 |
| Monarch Maternal Health | Health care | 501(c)(3) | 2026 | | | |
| Monument of Faith Church of God in Christ | Religion-related | 501(c)(3) | 2001 | | | |
| Moshiri Family Foundation U-T-A Dated 1-7-2021 | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 2021 | | $492 | 2025-12 |
| Mount Justice Missionary Baptist Church | Religion-related | 501(c)(3) | 1999 | | | |
| Mount Nebo Missionary Baptist Church | Religion-related | 501(c)(3) | 1997 | | | |
| Mt Hermon Missionary Baptist Church | Religion-related | 501(c)(3) | 1997 | | | |
| Mt Tabor Missionary Baptist Church | | 501(c)(3) | 1991 | | | |
| Music Scholarship Foundation Inc | Education | 501(c)(3) | 1999 | $0 | $0 | 2025-12 |
| Name Refugees and Immigrants Support Center | Human services | 501(c)(3) | 2024 | | | |
| National Benevolent Association of the Christian Church | Human services | 501(c)(3) | 1951 | | | |
| National Black Radio Hall of Fame | Arts, culture and humanities | 501(c)(3) | 2018 | $0 | $0 | 2025-12 |
| Nepali Gospel Church | | 501(c)(3) | 1965 | | | |
| Nerinx Hall High School | | 501(c)(3) | 1946 | | | |
| New Age Missionary Baptist Church Inc | Religion-related | 501(c)(3) | 1997 | | | |
| New Beginning Bible Ministries | Religion-related | 501(c)(3) | 2003 | | | |
| New Faith Tabernacle | | 501(c)(3) | 1983 | | | |
| New Generational Christian Center Church Inc | Religion-related | 501(c)(3) | 2008 | | | |
| New Jerusalem Temple Church of God | | 501(c)(3) | 1984 | | | |
| New Life Christian Fellowship North St Louis County | | 501(c)(3) | 1993 | | | |
| New Life Community Church of God in Christ LLC | | 501(c)(3) | 1969 | | | |
| New Life Community Temple Incorporated 1 | Religion-related | 501(c)(3) | 1999 | | | |
| New Life Ministries Christian Center | Religion-related | 501(c)(3) | 2010 | | | |
| New Life in Christ | Religion-related | 501(c)(3) | 1999 | | | |
| New Life of Praise Missionary Baptist Church | Religion-related | 501(c)(3) | 1998 | | | |
| New Millenium Church | | 501(c)(3) | 1984 | | | |
| New Mount Gideon West Baptist Church | | 501(c)(3) | 1978 | | | |
| New Shiloh Missionary Baptist Church | Religion-related | 501(c)(3) | 1998 | | | |
| New St James Missionary Baptist Church | Religion-related | 501(c)(3) | 2001 | | | |
| New Straightway Full Gospel Assembly Church Inc | | 501(c)(3) | 1979 | | | |
| New Testament Fellowship | | 501(c)(3) | 1980 | | | |
| New Union Vine Missionary Baptist Church | Religion-related | 501(c)(3) | 2000 | | | |
| Nithyananda Dhyanapeetam of Saint Louis | Religion-related | 501(c)(3) | 2008 | | | |
| Noahs Ark Church of God in Christ Inc | | 501(c)(3) | 1980 | | | |
| North Country Covenant Fellowship | | 501(c)(3) | 1980 | | | |
| Notre Dame Elementary School | | 501(c)(3) | 1946 | | | |
| Now Generation Inc | | 501(c)(3) | 1972 | | | |
| Office of Interfaith Coaltions | | 501(c)(3) | 1942 | | | |
| Old Path Faith Ministries | Religion-related | 501(c)(3) | 2002 | | | |
| Open Door House of Prayer | | 501(c)(3) | 1964 | | | |
| Open Door Missionary Fellowship Inc | | 501(c)(3) | 1956 | | | |
| Open Door Outreach Ministries Inc | Religion-related | 501(c)(3) | 2000 | | | |
| Orginal Corvette Club of St Louis | Recreation and sports | 501(c)(3) | 2025 | $0 | $0 | 2025-12 |
| Our Lady of Good Counsel Parish | | 501(c)(3) | 1946 | | | |
| Our Lady of Mercy Catholic Church | | 501(c)(3) | 1946 | | | |
| Our Lady of Victory Charitable Foundation | | 501(c)(3) | 1946 | | | |
| P & D Prayer & Deliverance Ministries Worship Center | Religion-related | 501(c)(3) | 2003 | | | |
| Payback Inc | | 501(c)(3) | 1988 | $0 | $0 | 2025-12 |
| Pentecostal Church of God II Inc | | 501(c)(3) | 1992 | | | |
| Pentecostal Church of God of Pagedale | | 501(c)(3) | 1980 | | | |
| Pentecostal Power Church | | 501(c)(3) | 1959 | | | |
| Perpetual Care Group Home for Veterans | Human services | 501(c)(3) | 2022 | $0 | $0 | 2025-12 |
| Perpetual Help Retirement Corporation | Religion-related | 501(c)(3) | 2004 | | | |
| Perpetual Praise & Worship Ministries | Religion-related | 501(c)(3) | 2004 | | | |
| Perry County Catholic Church Real Estate Corporation | | 501(c)(3) | 1946 | | | |
| Phillips Memorial M B C | | 501(c)(3) | 1991 | | | |
| Pi Mu Epsilon Inc | | 501(c)(3) | 1953 | $0 | $0 | 2025-06 |
| Pleasant Damascus Missionary Bapist Church | | 501(c)(3) | 1990 | | | |
| Pope John Paul II Catholic Elementary School | | 501(c)(3) | 1946 | | | |
| Poplar Institute for Film Corp | Arts, culture and humanities | 501(c)(3) | 2020 | $0 | $0 | 2024-12 |
| Power of Faith Ministries | Religion-related | 501(c)(3) | 2002 | | | |
| Presbyterian Mission International Inc | Religion-related | 501(c)(3) | 2003 | | | |
| Promise of Grace Assembly | | 501(c)(3) | 1964 | | | |
| Providence Baptist Church of St Louis | | 501(c)(3) | 1965 | | | |
| Qooba Foundation | Religion-related | 501(c)(3) | 2014 | | | |
| RHL Staenberg Foundation | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 2023 | | $3,347 | 2025-12 |
| Rajyam Foundation Corporation | Diseases, disorders and medical disciplines | 501(c)(3) | 2026 | | | |
| Reach for Life Wellness and Development | | 501(c)(3) | 2014 | $0 | $0 | 2026-08 |
| Restoration Fellowship Christian Church | Religion-related | 501(c)(3) | 1996 | | | |
| Restored By Grace | Human services | 501(c)(3) | 2016 | $0 | $0 | 2025-12 |
| Resurrection Charities Foundation | Human services | 501(c)(3) | 2021 | $0 | $0 | 2025-12 |
| Resurrection Church | | 501(c)(3) | 1987 | | | |
| Resurrection and Life Christian Center | Religion-related | 501(c)(3) | 2007 | | | |
| Revival Center Church of God in Christ International Inc | | 501(c)(3) | 1983 | | | |
| River of Life Revivals Inc | Religion-related | 501(c)(3) | 1994 | | | |
| Rivers of Life of Sunset Hills | | 501(c)(3) | 1979 | | | |
| Riverview Boulevard Baptist Churchincorporated | | 501(c)(3) | 1981 | | | |
| Rock Hill Turner Foundation | Science and technology | 501(c)(3) | 2024 | | | |
| Roseview Church of God in Christ | Religion-related | 501(c)(3) | 1999 | | | |
| SBC Village Inc | Human services | 501(c)(3) | 1998 | | | |
| SGK Foundation | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 1999 | | $62,558 | 2025-12 |
| SGSM Network Inc | Religion-related | 501(c)(3) | 2003 | | | |
| SSM Health Care St Louis | | 501(c)(3) | 1946 | | | |
| SSM Rehab | Health care | 501(c)(3) | 1946 | | | |
| STL Fashion Alliance | Human services | 501(c)(3) | 2023 | $0 | $0 | 2024-12 |
| STL Tax Counselors | Human services | 501(c)(3) | 2021 | $0 | $0 | 2025-12 |
| STL United | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 2026 | | | |
| Saint Marks Endowment Fund Inc | | 501(c)(3) | 1971 | | | |
| Saints Fellowship Mission Church Inc | | 501(c)(3) | | | | |
| Samuel Brown Temple Ame Zion | Religion-related | 501(c)(3) | 2003 | | | |
| Sandhurst Soccer Club | | 501(c)(3) | 2016 | $0 | $0 | 2024-06 |
| Second Christian Fellowship Church | | 501(c)(3) | 1979 | | | |
| Sheep Shed Center | | 501(c)(3) | 1986 | | | |
| Shield of Faith Full Gospel Baptist Church | Religion-related | 501(c)(3) | 1999 | | | |
| Shining Light Pentecostal Church | Religion-related | 501(c)(3) | 2003 | | | |
| Shining Star Missionary Baptist Church Inc | | 501(c)(3) | 1979 | | | |
| Sigma Phi Gamma International Sorority Inc | | 501(c)(7) | 1967 | | | |
| Sikh Dharma Brotherhood of St Louis Missouri | | 501(c)(3) | 1977 | | | |
| Simply the Word Ministries | Religion-related | 501(c)(3) | 2001 | | | |
| Sisters of Christ | Religion-related | 501(c)(3) | 2011 | $0 | $0 | 2025-12 |
| Sisters of Mercy Province of St Louis Self Ins Trust Fund 14447-41 | | 501(c)(3) | 1946 | | | |
| Society for the Prop of the Faith Archdiocese of St Louis Corp | | 501(c)(3) | 1946 | | | |
| Soulard Restoration Church | | 501(c)(3) | 1964 | | | |
| South County Baptist Church Foundation Inc | Religion-related | 501(c)(3) | 1995 | | | |
| Southern Christian Home Inc | | 501(c)(3) | 1951 | | | |
| Southside Christian Church | | 501(c)(3) | 1985 | | | |
| Spanish Lake Church of Christ | | 501(c)(3) | 1973 | | | |
| Spire Foundation | | 501(c)(3) | 1967 | | $5 million | 2025-09 |
| Spirit and Truth Fellowship Church | Religion-related | 501(c)(3) | 2003 | | | |
| St Aloysius Parish | | 501(c)(3) | 1946 | | | |
| St Bartholomew Roman Catholic Church | | 501(c)(3) | 1946 | | | |
| St Charles County Catholic Church Real Estate Corporation | | 501(c)(3) | 1946 | | | |
| St Christopher Parish | | 501(c)(3) | 1946 | | | |
| St Francois County Catholic Church Real Estate Corporation | | 501(c)(3) | 1946 | | | |
| St Hedwigs Parish | | 501(c)(3) | 1946 | | | |
| St John C O G I C 2 | Religion-related | 501(c)(3) | 1998 | | | |
| St John Temple United Hoyl Church of America Inc | | 501(c)(3) | 1990 | | | |
| St John of the Holy Trinity Church | | 501(c)(3) | 1993 | | | |
| St Joseph Hospital Augusta | Health care | 501(c)(3) | 1946 | | | 2007-06 |
| St Lauras Mission | | 501(c)(3) | 1990 | | | |
| St Louis Airport Interfaith Chaplaincy Inc | Religion-related | 501(c)(3) | 2024 | $0 | $0 | 2025-12 |