Data / Nonprofits / Missouri / Cpe Girardeau
Nonprofits in Cpe Girardeau, MO: 313 registered with the IRS
313 nonprofits are registered with the IRS in Cpe Girardeau, MO, 237 of them 501(c)(3) charities; the 104 that report revenue took in $1.61 billion. The largest by revenue: Saint Francis Medical Center ($767.2 million), Southeast Hospital ($404.5 million), Saint Francis Healthcare System ($215.9 million). Most common causes: religion-related (37), human services (26), education (24).
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Every organization, largest by revenue first
| Organization | Category | Type | Since | Revenue | Assets | Filing |
|---|---|---|---|---|---|---|
| Saint Francis Medical Center | Health care | 501(c)(3) | 1946 | $767.2 million | $1.15 billion | 2025-06 |
| Southeast Hospital | Health care | 501(c)(3) | 1929 | $404.5 million | $195.6 million | 2025-06 |
| Saint Francis Healthcare System | Health care | 501(c)(3) | 1995 | $215.9 million | $871.3 million | 2025-06 |
| Community Counseling Center | Mental health and crisis intervention | 501(c)(3) | 1989 | $41.6 million | $29.1 million | 2025-06 |
| Lutheran Home for the Aged | 501(c)(3) | 1983 | $27.7 million | $32.8 million | 2024-12 | |
| Saint Francis Healthcare Real Estate | Health care | 501(c)(3) | 2021 | $25.1 million | $201.8 million | 2025-06 |
| Cross Trails Medical Center | Education | 501(c)(3) | 1995 | $18.2 million | $20.5 million | 2025-12 |
| Cape Retirement Community Inc | 501(c)(3) | 1975 | $13.9 million | $24.2 million | 2024-12 | |
| Southeast Missouri University | Education | 501(c)(3) | 1984 | $12.9 million | $166.7 million | 2025-06 |
| Southeast Missouri Area Agency On Aging | Human services | 501(c)(3) | 1975 | $12.2 million | $5.7 million | 2025-06 |
| Gibson Center for Behavioral Change | Mental health and crisis intervention | 501(c)(3) | 1980 | $11.7 million | $13.8 million | 2025-06 |
| Semo Alliance for Disability Independence Inc-Fiscal Agent | Human services | 501(c)(3) | 1993 | $7.9 million | $8.3 million | 2025-06 |
| Mid America Teen Challenge Training Center Inc | Mental health and crisis intervention | 501(c)(3) | 1970 | $7.8 million | $20.3 million | 2025-06 |
| Community Partnership of Southeast Missouri | Community improvement and capacity building | 501(c)(3) | 1996 | $6.7 million | $3.5 million | 2025-06 |
| Cape Girardeau Community Sheltered Workshop Inc D/b/a Vip Industries | Employment | 501(c)(3) | 1929 | $4.1 million | $22.3 million | 2025-06 |
| Workforce Development Board of Southeast Missouri | Employment | 501(c)(3) | 2000 | $2.7 million | $338,053 | 2025-06 |
| Cape Girardeau Country Club Trust | 501(c)(7) | 1966 | $2.4 million | $3.3 million | 2024-12 | |
| Saint Francis Foundation | 501(c)(3) | 1946 | $2.2 million | $12.1 million | 2025-06 | |
| Humane Society of Southeast Mo | Animal-related | 501(c)(3) | 1980 | $1.9 million | $4.3 million | 2024-12 |
| Vip Vocational Services Inc Cape Girardeau Community Shelter | Employment | 501(c)(3) | 1986 | $1.8 million | $14.4 million | 2025-06 |
| Safe House for Women Inc | Human services | 501(c)(3) | 1991 | $1.6 million | $4.9 million | 2025-08 |
| Santa Cruz County Diaper Bank Inc | Religion-related | 501(c)(3) | 2022 | $1.5 million | $289,324 | 2025-12 |
| Lynwood Christian Academy | Education | 501(c)(3) | 2024 | $1.3 million | $254,325 | 2025-06 |
| Prodigy Leadership Academy | Education | 501(c)(3) | 2010 | $1.3 million | $1.8 million | 2024-07 |
| Boys and Girls Clubs of Southeast Missouri Inc | Youth development | 501(c)(3) | 1965 | $1.2 million | $500,483 | 2025-07 |
| Laborers International Union of North America | 501(c)(5) | 1968 | $1 million | $2.5 million | 2025-09 | |
| Benevolent & Protective Order of Elks of the USA | 501(c)(8) | 1951 | $886,801 | $1.1 million | 2026-03 | |
| United Way of Southeast Missouri | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 1956 | $878,887 | $1.7 million | 2025-06 |
| Cape Girardeau Chamber of Commerce | 501(c)(6) | 1945 | $862,475 | $1.3 million | 2024-12 | |
| Cape Girardeau Council On Aging | Human services | 501(c)(3) | 1975 | $712,581 | $366,828 | 2025-06 |
| Habitat for Humanity International Inc | 501(c)(3) | 1987 | $703,757 | $4.5 million | 2025-06 | |
| New Vision Youth and Family Services Inc | Human services | 501(c)(3) | 1998 | $661,407 | $662,983 | 2025-12 |
| Cape Girardeau Public School Foundation | Education | 501(c)(3) | 2000 | $586,618 | $903,657 | 2025-12 |
| Old Town Cape Inc | Arts, culture and humanities | 501(c)(3) | 2000 | $575,827 | $324,528 | 2025-12 |
| Kids Korner Daycare and Preschool Center | Human services | 501(c)(3) | 2015 | $522,721 | $18,860 | 2024-12 |
| Tailor Institute Incorporated | Diseases, disorders and medical disciplines | 501(c)(3) | 2005 | $512,543 | $222,846 | 2025-06 |
| Southeast Missouri Regional Economic Development Inc | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 1994 | $473,999 | $730,238 | 2024-12 |
| Arts Council of Southeast Missouri | Arts, culture and humanities | 501(c)(3) | 1968 | $470,952 | $353,958 | 2025-06 |
| Options for Women | Human services | 501(c)(3) | 2014 | $453,790 | $665,700 | 2025-06 |
| Southeast Missouri Hospital Foundation | Health care | 501(c)(3) | 1978 | $409,890 | $5.7 million | 2025-06 |
| Youth Substance Abuse Prevention Coalition | Mental health and crisis intervention | 501(c)(3) | 2008 | $404,951 | $158,719 | 2025-06 |
| Southeast Missouri Childrens Museum | Arts, culture and humanities | 501(c)(3) | 2006 | $382,933 | $801,696 | 2025-12 |
| Veterans of Foreign Wars Dept of Missouri | 501(c)(19) | 1966 | $365,977 | $1.2 million | 2025-06 | |
| Fraternal Order of Eagles | 501(c)(8) | 1991 | $351,197 | $1.6 million | 2025-05 | |
| United Brotherhood of Carpenters & Joiners of America 1770 | 501(c)(5) | 1940 | $342,834 | $191,714 | 2025-06 | |
| Board of Directors Street Level Cape Girardeau Inc | Human services | 501(c)(3) | 2022 | $320,013 | $39,904 | 2025-12 |
| Chateau Girardeau Fondation | 501(c)(3) | 1985 | $315,520 | $455,713 | 2025-12 | |
| Southeastern Missouri Area Health Education Center Inc | Health care | 501(c)(3) | 2014 | $315,475 | $587,495 | 2025-09 |
| Birthright of Cape Girardeau Inc | Civil rights, social action and advocacy | 501(c)(3) | 1977 | $281,432 | $601,659 | 2025-12 |
| Porch Initiative | Human services | 501(c)(3) | 2024 | $250,649 | $317,484 | 2025-12 |
| Pure Word Communications | Religion-related | 501(c)(3) | 2011 | $246,832 | $439,306 | 2024-12 |
| Southeast Missouri Realtors | Community improvement and capacity building | 501(c)(6) | 2011 | $244,964 | $452,798 | 2025-12 |
| Cape Girardeau Veterans Home Foundation | Human services | 501(c)(3) | 1995 | $243,459 | $1.8 million | 2025-12 |
| South Side Farms | Human services | 501(c)(3) | 2023 | $237,348 | $532,808 | 2025-12 |
| Southeast Missouri Preparatory School | Education | 501(c)(3) | 2022 | $235,355 | $34,702 | 2026-04 |
| Operative Plasterers & Cement Masons International Association | 501(c)(5) | 1966 | $218,271 | $327,512 | 2025-12 | |
| Cape Girardeau Missouri Parks Development Foundation | 501(c)(3) | 1993 | $209,353 | $1 million | 2025-06 | |
| Court Appointed Special Advocates of Southeast Missouri Inc | Civil rights, social action and advocacy | 501(c)(3) | 1993 | $207,821 | $337,035 | 2025-06 |
| Knights of Columbus | 501(c)(8) | 1940 | $203,687 | $218,925 | 2025-06 | |
| Semo Alliance for Disability Independence Foundation Inc | Human services | 501(c)(3) | 2005 | $189,871 | $2.5 million | 2025-06 |
| Missouri Zeta Alumni Association of Sigma Phi Epsilon Fraternity | Recreation and sports | 501(c)(7) | 2016 | $181,888 | $2,512 | 2026-06 |
| Doctors Park Professional Association Inc | Community improvement and capacity building | 501(c)(4) | 2018 | $170,792 | $53,473 | 2025-12 |
| James Reynolds House Foundation | Arts, culture and humanities | 501(c)(3) | 2012 | $165,563 | $22,425 | 2025-12 |
| Baptist Student Center of Southeast Missouri | Religion-related | 501(c)(3) | 2001 | $158,501 | $1.5 million | 2024-12 |
| Regency House of Cape Girardeau Inc 1330 State Hwy 74 | 501(c)(3) | 1989 | $142,333 | $447,009 | 2025-06 | |
| Optimist International | 501(c)(4) | 1958 | $128,170 | $109,604 | 2025-09 | |
| Communication Workers of America | 501(c)(5) | 1951 | $127,960 | $256,111 | 2025-09 | |
| Regency House of Jackson Inc 1330 State Hwy 74 | 501(c)(3) | 1989 | $123,168 | $327,343 | 2025-06 | |
| Missourians for Transportation Investment | Community improvement and capacity building | 501(c)(6) | 2016 | $117,550 | $5,989 | 2024-12 |
| Global Catholicism Foundation | Religion-related | 501(c)(3) | 2023 | $111,481 | $30,035 | 2024-12 |
| Missouri Council of Career & Technical Administrators | 501(c)(6) | 1991 | $107,368 | $18,030 | 2025-06 | |
| Southeast Missouri District Fair Foundation | Recreation and sports | 501(c)(3) | 2015 | $104,598 | $642,422 | 2025-12 |
| Restore the Wonder Ministries | Religion-related | 501(c)(3) | 2022 | $99,730 | $96,160 | 2024-12 |
| Pure Word Radio Inc | Religion-related | 501(c)(3) | 2021 | $94,725 | $98,977 | 2024-12 |
| International Association of Lions Clubs | 501(c)(4) | $92,161 | $72,081 | 2025-06 | ||
| Jackson Area Youth Football | Recreation and sports | 501(c)(3) | 2026 | $85,725 | $40,057 | 2025-12 |
| Missouri Zeta Chapter of the Sigma Phi Epsilon Fraternity | Education | 501(c)(7) | 2025 | $85,204 | $1,011 | 2025-12 |
| Alpha Kappa Educational Foundation | Education | 501(c)(3) | 2003 | $84,187 | $1.3 million | 2025-12 |
| Grace Recovery Inc | Human services | 501(c)(3) | 2017 | $83,898 | $396,048 | 2025-06 |
| Community Counseling Center Foundation | 501(c)(3) | 1946 | $82,821 | $2.6 million | 2025-06 | |
| New Morning Apartments Inc | Housing and shelter | 501(c)(3) | 2006 | $80,693 | $1.2 million | 2025-12 |
| Regency House of Marble Hill Inc 1330 State Hwy 74 | 501(c)(3) | 1989 | $73,914 | $124,895 | 2025-06 | |
| Independent Electrical Contractors Inc | 501(c)(6) | 1998 | $69,664 | $14,582 | 2025-12 | |
| The Lemondrop Foundation | Diseases, disorders and medical disciplines | 501(c)(3) | 2025 | $65,078 | $25,322 | 2025-12 |
| Regency Terrace of Cape Girardeau Inc | Human services | 501(c)(3) | 1995 | $55,561 | $250,645 | 2025-06 |
| Gamma Phi Beta Sorority Inc | 501(c)(7) | 1959 | $54,471 | $54,659 | 2025-07 | |
| Rotary International | 501(c)(4) | 1958 | $52,551 | $69,720 | 2025-06 | |
| American Legion | 501(c)(19) | 1946 | $51,409 | $239,047 | 2024-12 | |
| Zonta Club of Cape Girardeau Area Foundation | Education | 501(c)(3) | 2003 | $50,469 | $71,592 | 2026-05 |
| Toy Box Trust | Human services | 501(c)(3) | 1992 | $44,764 | $40,239 | 2024-12 |
| Knights of Columbus | 501(c)(8) | 1940 | $44,697 | $31,958 | 2025-12 | |
| VFW Post 3838 Avenue of Flags | Public and societal benefit | 501(c)(3) | 2025 | $43,862 | $98,650 | 2025-06 |
| Knights of Columbus | 501(c)(8) | 1940 | $41,592 | $231,434 | 2025-12 | |
| Missouri Association for Persons With Intellectual Disabilities Inc | Public and societal benefit | 501(c)(3) | 1994 | $38,965 | $1.5 million | 2025-06 |
| National Association of Letter Carriers | Employment | 501(c)(5) | 2024 | $38,836 | $54,836 | 2025-12 |
| Friends of the Cape Girardeau Public Library | 501(c)(3) | 1980 | $38,634 | $187,363 | 2025-06 | |
| Cape Central All School Booster Cllub Inc | Education | 501(c)(3) | 2004 | $31,877 | $46,537 | 2025-05 |
| How Ministries | Religion-related | 501(c)(3) | 2014 | $24,000 | $177,413 | 2026-03 |
| Central High School Band Boosters | Community improvement and capacity building | 501(c)(3) | 1993 | $22,621 | $25,097 | 2025-12 |
| 4 Sight Counseling | Health care | 501(c)(3) | 2006 | $12,266 | $8,453 | 2025-12 |
| River City Rodders LTD | Recreation and sports | 501(c)(7) | 2015 | $10,095 | $9,234 | 2025-12 |
| Missouri Innovation Corporation | Education | 501(c)(3) | 2006 | $5,161 | $29,492 | 2025-06 |
| Southeast Health Center of Ripley County | Health care | 501(c)(3) | 2013 | $3,812 | $0 | 2025-06 |
| Melaina Cunningham and Friends Park Fund | Recreation and sports | 501(c)(3) | 2010 | $250 | $734,703 | 2024-12 |
| Abbey Road Christian Church | 501(c)(3) | 1951 | ||||
| Abundant and Free Ministries Inc | Religion-related | 501(c)(3) | 2019 | $0 | $0 | 2025-12 |
| Alpha Chi Sigma Fraternity Collegiate Chapter | 501(c)(3) | 1941 | $0 | $0 | 2025-12 | |
| Alpha Epsilon Delta | Education | 501(c)(3) | 1950 | $0 | $0 | 2024-12 |
| Alpha Phi Omega | 501(c)(3) | 1966 | $0 | $0 | 2024-12 | |
| American Federation of Labor and Congress of Industrial Orgs | 501(c)(5) | 1956 | $0 | $0 | 2025-12 | |
| American Legion Auxiliary | 501(c)(19) | 1946 | $0 | $0 | 2025-09 | |
| American Postal Workers Union | 501(c)(5) | 1973 | $0 | $0 | 2025-12 | |
| Ancient Free & Accepted Masons of Missouri | 501(c)(10) | 1940 | $0 | $0 | 2025-12 | |
| Assembly of God | 501(c)(3) | 1964 | ||||
| Astronomical Association of Southeast Missouri | Science and technology | 501(c)(3) | 2022 | $0 | $0 | 2024-12 |
| Baptist Collegiate Ministries of Southeast Missouri | Religion-related | 501(c)(3) | 2006 | |||
| Benefit for Beau | Public and societal benefit | 501(c)(3) | 2017 | $0 | $0 | 2025-12 |
| Bennett Family Foundation | Youth development | 501(c)(3) | 2024 | $0 | $0 | 2025-12 |
| Beta Alpha Psi National Council | 501(c)(3) | 1974 | $0 | $0 | 2025-12 | |
| Bethany Baptist Church Cape Girardeau | 501(c)(3) | 1965 | ||||
| Bethel Assembly of God | 501(c)(3) | 1964 | ||||
| Beyond the Badge | Crime and legal-related | 501(c)(3) | 2021 | $0 | $0 | 2025-12 |
| Blanchard Pto | Education | 501(c)(3) | 2016 | $0 | $0 | 2025-07 |
| Bridge Church Inc | Religion-related | 501(c)(3) | 2018 | |||
| Brookwood Services | Human services | 501(c)(3) | 2023 | $0 | $0 | 2025-12 |
| Bulldog Prep Inc | Recreation and sports | 501(c)(3) | 2026 | |||
| Calvary Ministries II | 501(c)(3) | 1989 | ||||
| Capaha Antique Car Club | Recreation and sports | 501(c)(4) | 2002 | $0 | $0 | 2024-12 |
| Cape Area Community Housing Development Corporation Inc | Community improvement and capacity building | 501(c)(3) | 2018 | $0 | $0 | 2026-06 |
| Cape Baptist Church | Religion-related | 501(c)(3) | 2025 | |||
| Cape Bible Chapel Inc | 501(c)(3) | 1965 | 2013-12 | |||
| Cape Cares Inc | Human services | 501(c)(3) | 2026 | |||
| Cape Community Church of God | 501(c)(3) | 1960 | ||||
| Cape County Soccer Club | Recreation and sports | 501(c)(3) | 2024 | $0 | $0 | 2024-12 |
| Cape Family Church Inc | Religion-related | 501(c)(3) | 1998 | |||
| Cape Girardeau Bats | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 2016 | $0 | $0 | 2023-12 |
| Cape Girardeau County 100 Club | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 2024 | |||
| Cape Girardeau Noon Lions Club Foundation | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 2017 | $109,477 | 2025-12 | |
| Cape Girardeau Presbyterian Church | 501(c)(3) | 1974 | ||||
| Cape Girardeau Roller Derby | Recreation and sports | 501(c)(3) | 2023 | $0 | $0 | 2025-12 |
| Cape Girardeau Senior Center Foundation Inc | Recreation and sports | 501(c)(3) | 1996 | $0 | $0 | 2025-06 |
| Cape Girardeau West Rotary Club Foundation Inc | Community improvement and capacity building | 501(c)(3) | 2017 | $0 | $0 | 2026-06 |
| Cape Nobles Inc | Human services | 501(c)(3) | 2016 | $0 | $0 | 2023-12 |
| Cape River Heritage Museum Inc | Arts, culture and humanities | 501(c)(3) | 2013 | $0 | $0 | 2024-12 |
| Caruthers Street Charities Inc | Human services | 501(c)(3) | 2004 | $0 | $0 | 2025-12 |
| Centenary United Methodist Church | 501(c)(3) | 1974 | 2011-12 | |||
| Central States Baptist Association | Religion-related | 501(c)(3) | 2015 | $0 | $0 | 2024-12 |
| Chaffee Public Schools Foundation | Education | 501(c)(3) | 1999 | $1.5 million | 2024-12 | |
| Chi Alpha Campus Ministry | 501(c)(3) | 1964 | ||||
| Christ Church of the Heartland Inc | Religion-related | 501(c)(3) | 2000 | |||
| Christ Disciples Fellowship | Religion-related | 501(c)(3) | 2025 | $0 | $0 | 2025-12 |
| Christ Episcopal Church | 501(c)(3) | 1971 | ||||
| Christian Boxing Academy & Learning Center | Youth development | 501(c)(3) | 2018 | $0 | $0 | 2025-12 |
| Christian Faith Fellowship | 501(c)(3) | 1986 | ||||
| Church of Christ | Religion-related | 501(c)(3) | 2002 | |||
| Compass United Methodist Church | 501(c)(3) | 1974 | ||||
| Cornerstone Church | 501(c)(3) | 1991 | ||||
| Dayspring From On High | 501(c)(3) | 1986 | $0 | $0 | 2025-12 | |
| Delta Chi Fraternity | 501(c)(7) | 1972 | $0 | $0 | 2025-06 | |
| Disabled American Veterans | 501(c)(4) | 1942 | $0 | $0 | 2026-06 | |
| Drew Jones Memorial Scholarship Fund | Education | 501(c)(3) | 2021 | $13,716 | 2025-12 | |
| Eagle Ridge Christian School Inc | Education | 501(c)(3) | 1997 | |||
| Egypt Mills Antique Tractor Club | 501(c)(4) | 1982 | $0 | $0 | 2026-03 | |
| Emerald Street Church of God | 501(c)(3) | 1960 | ||||
| Executive Board of the Missouri Baptist Convertion | 501(c)(3) | 1965 | ||||
| First Assembly of God | Religion-related | 501(c)(3) | 1964 | 2006-12 | ||
| First Assembly of God | 501(c)(3) | 1964 | ||||
| Fish Volunteer of Cape Girardeau | Food, agriculture and nutrition | 501(c)(3) | 2025 | $0 | $0 | 2025-12 |
| Football Championship Series Offici Als Alliance | Recreation and sports | 501(c)(3) | 2026 | |||
| Fourteenth District- American Legion-Department of Missouri | Public and societal benefit | 501(c)(19) | 2010 | $0 | $0 | 2026-07 |
| Frank the Fighter Foundation | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 2015 | $0 | $0 | 2025-12 |
| Fraternal Order of Eagles | 501(c)(8) | 1991 | $0 | $0 | 2025-05 | |
| Fraternal Order of Police | 501(c)(8) | 1952 | $0 | $0 | 2025-12 | |
| Good Shepherd Lutheran Church | Religion-related | 501(c)(3) | 1941 | |||
| Grace Church Cape Girardeau | 501(c)(3) | 1993 | ||||
| Grace United Methodist Church Foundation Inc | 501(c)(3) | 1984 | $0 | $0 | 2023-12 | |
| Granting Grace Outreach | Human services | 501(c)(3) | 2019 | $0 | $0 | 2024-12 |
| Greater Cape Girardeau Industrial P Ark Sewer Association Corporation | Community improvement and capacity building | 501(c)(4) | 2026 | $0 | $0 | 2026-06 |
| Greater Dimension Church of God in Christ | Religion-related | 501(c)(3) | 1996 | |||
| Greyhound Pets of America | 501(c)(3) | 1989 | $0 | $0 | 2024-12 | |
| Hanover Lutheran Church | 501(c)(3) | 1941 | ||||
| Happy Slapowitzs Toy Bash Inc | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 2014 | $0 | $0 | 2025-12 |
| Health Careers Foundation Inc | Education | 501(c)(3) | 2014 | $0 | $1 | 2025-12 |
| Heart2help | Arts, culture and humanities | 501(c)(3) | 2020 | $0 | $0 | 2025-12 |
| Heartland Homeschool Association | Education | 501(c)(3) | 2017 | $0 | $0 | 2026-06 |
| Heartland Sole Providers Inc | Human services | 501(c)(3) | 2011 | $0 | $0 | 2024-06 |
| Hopewell Cemetery Association | Mutual and membership benefit | 501(c)(13) | 2014 | $0 | $0 | 2024-12 |
| House of Prayer Outreach Mission Inc | 501(c)(3) | 1991 | ||||
| Howard L Aslinger Memorial Scholarship for Individuals With D | Education | 501(c)(3) | 2010 | $0 | $0 | 2026-01 |
| Ihope Foundation Inc | Environment | 501(c)(3) | 2020 | $0 | $0 | 2024-12 |
| Imani Women Empowerment Program USA | Human services | 501(c)(3) | 2025 | $0 | $0 | 2024-12 |
| In His Image Ministries | 501(c)(3) | 2009 | ||||
| International Assocation of Fire Fighters | 501(c)(5) | 1959 | $0 | $0 | 2024-09 | |
| International Association of Lions Clubs | 501(c)(4) | 1940 | $0 | $0 | 2025-06 | |
| International Association of Sheet Metal Air Rail & Transportation | 501(c)(5) | 2015 | $0 | $0 | 2025-12 | |
| Iona Baptist Church | 501(c)(3) | 1965 | ||||
| Islamic Center of Cape Girardeau | Religion-related | 501(c)(3) | 2020 | |||
| It Takes A Village - Semo | 501(c)(3) | 2019 | $0 | $0 | 2025-12 | |
| Jack Finney Memorial Wellness Fund | Health care | 501(c)(3) | 2021 | $0 | $0 | 2025-12 |
| Jennifer Land Ministries | Religion-related | 501(c)(3) | 2012 | $0 | $0 | 2025-12 |
| Jr Crusaders Football Program | Recreation and sports | 501(c)(3) | 2025 | $0 | $0 | 2025-12 |
| Kids in Christian Karate School | Recreation and sports | 501(c)(3) | 2015 | $0 | $0 | 2025-12 |
| Knights of Columbus | 501(c)(8) | 1940 | $0 | $0 | 2024-12 | |
| La Croix Church Inc | Religion-related | 501(c)(3) | 2023 | |||
| Lamb Solutions NFP | Housing and shelter | 501(c)(3) | 2024 | $0 | $0 | 2025-12 |
| Lan F and Irma J Coots Charitable Foundation | Education | 501(c)(3) | 2023 | $1 million | 2025-12 | |
| Levis Childrens Charity | Health care | 501(c)(3) | 2014 | $0 | $0 | 2025-12 |
| Lick Creek Chapel Cemetery Association | Mutual and membership benefit | 501(c)(3) | 2023 | $0 | $0 | 2025-05 |
| Lifes Word Ministries Inc | 501(c)(3) | 1964 | ||||
| Lynwood Baptist Church | 501(c)(3) | 1965 | ||||
| Marian Charities Inc | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 1994 | $15.4 million | 2025-12 | |
| Marine Corps League | 501(c)(4) | 1946 | $0 | $0 | 2026-06 | |
| Marine Corps League | 501(c)(4) | 1946 | $0 | $0 | 2026-06 | |
| Marine Corps League | 501(c)(4) | 1946 | $0 | $0 | 2026-06 | |
| Marine Corps League | 501(c)(4) | 1968 | $0 | $0 | 2026-06 | |
| Midwest Ministry Care Center Inc | Religion-related | 501(c)(3) | 2012 | |||
| Missouri Education Reform Council | Education | 501(c)(4) | 2009 | $0 | $0 | 2025-12 |
| Missouri Paint for A Cause | Education | 501(c)(3) | 2019 | $0 | $0 | 2025-12 |
| Missouri Society of Professional Engineers | 501(c)(6) | 1945 | $0 | $0 | 2026-06 | |
| Modern Woodmen of America | 501(c)(8) | 1961 | $0 | $0 | 2025-12 | |
| Modern Woodmen of America | 501(c)(8) | 1961 | $0 | $0 | 2025-12 | |
| Modern Woodmen of America | 501(c)(8) | 1972 | $0 | $0 | 2025-12 | |
| Modern Woodmen of America | 501(c)(9) | 1961 | $0 | $0 | 2025-12 | |
| Modern Woodmen of America | 501(c)(8) | 1961 | $0 | $0 | 2025-12 | |
| Modern Woodmen of America | 501(c)(8) | 1961 | $0 | $0 | 2025-12 | |
| Modern Woodmen of America | 501(c)(8) | 1961 | $0 | $0 | 2025-12 | |
| Modern Woodmen of America | 501(c)(8) | 1961 | $0 | $0 | 2025-12 | |
| Modern Woodmen of America | 501(c)(8) | 1961 | $0 | $0 | 2025-12 | |
| Modern Woodmen of America | 501(c)(8) | 1961 | $0 | $0 | 2025-12 | |
| More Grace Ministries Inc | Human services | 501(c)(3) | 2026 | |||
| Mt Tabor Charitable Foundation | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 2016 | $16.7 million | 2025-12 | |
| My Fathers Church | 501(c)(3) | 1985 | ||||
| National Society of the Daughters of the American Revolution | 501(c)(3) | 1949 | $0 | $0 | 2025-12 | |
| New Beginnings Church of Deliverance | Religion-related | 501(c)(3) | 2004 | |||
| New Plymouth Community Church | 501(c)(3) | 1994 | ||||
| New Prayer of Deliverance Ministries | Religion-related | 501(c)(3) | 2020 | |||
| Olin S McDaniel Amd Council 259 | Mutual and membership benefit | 501(c)(10) | 2024 | $0 | $0 | 2025-12 |
| Oncology Nursing Society | 501(c)(6) | 1981 | ||||
| Optimist International | 501(c)(4) | 1958 | $0 | $0 | 2025-09 | |
| Oral Health Coalition of Southeast Missouri | Public and societal benefit | 501(c)(3) | 2022 | $0 | $0 | 2025-12 |
| Oscar C Hirsch Foundation | 501(c)(3) | 1964 | $1.5 million | 2024-12 | ||
| Out of Poverty Thru Education Inc | International, foreign affairs and national security | 501(c)(3) | 2010 | $0 | $0 | 2025-12 |
| Overcomers | 501(c)(3) | 1972 | 2010-12 | |||
| Partners for Good Hope NP | Community improvement and capacity building | 501(c)(3) | 2024 | $0 | $0 | 2025-12 |
| Paul E & Helen S Meyer Foundation | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 1995 | $537,168 | 2024-12 | |
| Pflag Cape Girardeau | 501(c)(3) | 1943 | $0 | $0 | 2025-09 | |
| Phi Eta Sigma National Honor Society Inc | Education | 501(c)(3) | 2014 | $0 | $0 | 2020-06 |
| Pinnacle of Faith Life Changing Ministries | Religion-related | 501(c)(3) | 2015 | |||
| Play for Parker Foundation | Public and societal benefit | 501(c)(3) | 2015 | $0 | $0 | 2025-12 |
| Pride Cape | Civil rights, social action and advocacy | 501(c)(3) | 2023 | $0 | $0 | 2025-12 |
| Psi Chi the National Honor Society in Psychology | 501(c)(3) | 1957 | $0 | $0 | 2025-06 | |
| Rad Studios | Arts, culture and humanities | 501(c)(3) | 2026 | |||
| Red Star Neighborhood Revival Incorporation | Community improvement and capacity building | 501(c)(3) | 2016 | $0 | $0 | 2025-12 |
| Relationship Not Religion Ministries Inc | Religion-related | 501(c)(3) | 2018 | $0 | $0 | 2023-12 |
| Renaissance World Mission Inc | Religion-related | 501(c)(3) | 2016 | |||
| Revival Center Church | Religion-related | 501(c)(3) | 1999 | |||
| Rhodes Foundation Inc | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 2022 | $2.3 million | 2025-12 | |
| River City Players Cape Girardeaus Community Theatre | Arts, culture and humanities | 501(c)(3) | 2002 | $0 | $0 | 2025-10 |
| Road Runners Club of America | Health care | 501(c)(3) | 1976 | $0 | $0 | 2025-12 |
| Robert and Anna Drury Family Foundation Trust | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 2013 | $21.2 million | 2025-06 | |
| Ronnies Outreach | Mental health and crisis intervention | 501(c)(3) | 2024 | $0 | $0 | 2025-12 |
| Room for One More | Human services | 501(c)(3) | 2009 | $0 | $0 | 2025-12 |
| Rotary International | 501(c)(4) | 1966 | $0 | $0 | 2025-06 | |
| Rotary International | 501(c)(4) | 1942 | $0 | $0 | 2025-06 | |
| Sacred Space Ministries Inc | Religion-related | 501(c)(3) | 2015 | $0 | $0 | 2025-12 |
| Scriptural Lutheran Church | 501(c)(3) | 1972 | ||||
| Second Missionary Baptist Church of Cape Girardeau | Religion-related | 501(c)(3) | 2008 | |||
| Semo Crisis Intervention Team Council | Mental health and crisis intervention | 501(c)(3) | 2024 | $0 | $0 | 2026-06 |
| Semo Elite FC | Recreation and sports | 501(c)(3) | 2025 | $0 | $0 | 2025-12 |
| Semo Mission Minded Inc | Recreation and sports | 501(c)(3) | 2022 | $0 | $0 | 2024-12 |
| Semo Peer Support | Mental health and crisis intervention | 501(c)(3) | 2023 | $0 | $0 | 2025-12 |
| Semo Power of Praying Women | Religion-related | 501(c)(3) | 2022 | $0 | $0 | 2025-12 |
| Semo Regional Industrial Training Group | Education | 501(c)(3) | 1996 | $0 | $0 | 2024-12 |
| Seniors and Lawmen Together Inc | Crime and legal-related | 501(c)(3) | 2016 | $0 | $0 | 2025-12 |
| Set Apart Ministries | Religion-related | 501(c)(3) | 2026 | |||
| Sigma Gamma Rho Sorority Inc | 501(c)(7) | 1962 | $0 | $0 | 2026-06 | |
| Sigma Nu Fraternity | 501(c)(7) | 1940 | $0 | $0 | 2025-06 | |
| Sigma Sigma Sigma Inc | 501(c)(7) | 1943 | ||||
| Sigma Theta Tau Inc | 501(c)(3) | 1954 | $0 | $0 | 2026-06 | |
| Society of St Vincent de Paul St Marys Conference | Human services | 501(c)(3) | 2014 | $0 | $0 | 2025-09 |
| Southeasthealth System Inc | Health care | 501(c)(3) | 2016 | $0 | $0 | 2025-06 |
| St Andrews Lutheran Church | 501(c)(3) | 1941 | ||||
| St Mark Lutheran Church | 501(c)(3) | 1988 | ||||
| Stonebright Foundation | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 1997 | $338,815 | 2025-12 | |
| Stop Needless Acts of Violence Please - Snap | Crime and legal-related | 501(c)(3) | 2019 | $0 | $0 | 2025-12 |
| Student Santa | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 2010 | $0 | $0 | 2024-12 |
| Student Veterans Organization | Housing and shelter | 501(c)(3) | 2015 | $0 | $0 | 2025-12 |
| Tank of Love Charity | Food, agriculture and nutrition | 501(c)(3) | 2024 | $0 | $0 | 2025-12 |
| The Cape Girardeau Unitarian Universalist Fellowship | Religion-related | 501(c)(3) | 2008 | |||
| The Church of the Rescued and Redeemed | 501(c)(3) | 1965 | ||||
| The Lion of Judah International Association of Outreach Ministries | Religion-related | 501(c)(3) | 2012 | |||
| The Mary Ann and Bert J Kellerman Foundation | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 2013 | $1.2 million | 2024-12 | |
| The River City Workers of the Blind | 501(c)(3) | 1983 | $0 | $0 | 2025-12 | |
| Theology of the Body Educators | Religion-related | 501(c)(3) | 2025 | $0 | $0 | 2025-12 |
| Toastmasters International | Arts, culture and humanities | 501(c)(3) | 1945 | $0 | $0 | 2025-12 |
| Transamerica Corridor | Public and societal benefit | 501(c)(4) | 2026 | $0 | $55,105 | 2025-12 |
| Tri-State Neurotherapy and Stroke Support Group Foundation | Mental health and crisis intervention | 501(c)(3) | 2023 | $0 | $0 | 2025-05 |
| Trinity Lutheran Church | 501(c)(3) | 1941 | ||||
| Trinity Lutheran Church of Egypt Mills Cemetery Association | Mutual and membership benefit | 501(c)(13) | 2020 | $0 | $0 | 2024-12 |
| Trinity Lutheran School Foundation | 501(c)(3) | 1993 | $0 | $0 | 2024-12 | |
| United Commercial Travelers of America | 501(c)(8) | 1940 | $0 | $0 | 2024-12 | |
| United Steelworkers | 501(c)(5) | 1940 | $0 | $0 | 2025-12 | |
| University Lutheran Chapel of Hope | Religion-related | 501(c)(3) | 2012 | |||
| VFW Auxiliary Department of Missouri | 501(c)(4) | 1970 | $0 | $0 | 2025-06 | |
| VFW Auxiliary Department of Missouri | 501(c)(4) | 1970 | $0 | $0 | 2024-12 | |
| Veterans of Foreign Wars Dept of Missouri | 501(c)(19) | 1961 | $0 | $0 | 2025-12 | |
| Vision House of Cape Girardeau | Mental health and crisis intervention | 501(c)(3) | 2004 | $0 | $0 | 2025-06 |
| Vision of Hope International | Human services | 501(c)(3) | 1997 | $0 | $0 | 2025-12 |
| Westray Foundation | Arts, culture and humanities | 501(c)(3) | 2005 | $0 | $0 | 2025-06 |
| White Horse Youth Ranch | Animal-related | 501(c)(3) | 2007 | $80,702 | 2024-09 | |
| Zeta Phi Beta Sorority Inc | 501(c)(7) | 1960 | $0 | $0 | 2026-06 | |
| Zion United Methodist Church | 501(c)(3) | 1974 | 2011-12 | |||
| Zonta International | 501(c)(4) | 1953 | $0 | $0 | 2025-05 |
By cause in Cpe Girardeau, MO
- Religion-related 37
- Human services 26
- Education 24
- Recreation and sports 15
- Philanthropy, voluntarism and grantmaking foundations 15
- Health care 12
- Arts, culture and humanities 10
- Community improvement and capacity building 10
- Mental health and crisis intervention 9
- Public and societal benefit 7
- Mutual and membership benefit 4
- Employment 4
- Crime and legal-related 3
- Youth development 3
- Civil rights, social action and advocacy 3
- Housing and shelter 3
Nonprofits in every city of the state
Read from the IRS Exempt Organizations Business Master File, updated by the IRS on October 24, 2026 and rebuilt here every morning. Revenue and assets are from each organization's latest filing as the IRS lists it; the IRS record is the official one. Organizations only: no people are named on these pages.