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Data / Research funding / Stem Cell Research

Stem Cell Research: 4,596 NIH awards ($4B) to 489 organizations

4,596 NIH awards ($4B) in the NIH spending category Stem Cell Research, to 489 organizations, read 2026-11-03. NIH fiscal years 2021 to 2025.

SpecStream is the live web data engine for teams and agents. It reads the NIH and NSF award files each time the agencies update them, and this page is that reading, joined to the open federal funding opportunities on Grants.gov. Ask for the awards you track by topic, organization or state and new awards arrive in your sheet, CRM, Slack or agent as the agencies publish them.

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NIH spending category

Awards

The 500 largest of 4,596 awards in the window.

AwardAgencyInstitute or divisionFiscal yearAmount in windowStartEndPrincipal investigatorSource
Limited Competition: Continuation of the Center for Genomic Studies on Mental DisordersNIHNational Institute of Mental Health2021 to 2024$39,202,732July 1, 2003February 28, 2026KNOWLES, JAMES Areporter.nih.gov
Idaho INBRE ProgramNIHNational Institute of General Medical Sciences2021 to 2025$21,939,274September 30, 2001August 31, 2030BOHACH, CAROLYN HOVDEreporter.nih.gov
UCCC P30 Supplement: Human Endogenous Retrovirus-H as a Target for Early-Onset Colorectal CancerNIHNational Cancer Institute2021 to 2025$21,851,455September 1, 2025August 31, 2026SCHULICK, RICHARD Dreporter.nih.gov
Nebraska Research Network in Functional GenomicsNIHNational Institute of General Medical Sciences2021 to 2025$20,833,603September 30, 2001April 30, 2026SORGEN, PAUL Lreporter.nih.gov
Cancer Center Support GrantNIHNational Cancer Institute2021 to 2025$19,528,719June 1, 1997June 30, 2028STEIDL, ULRICHreporter.nih.gov
Baylor College of Medicine Cancer Center - Cancer Center Support GrantNIHNational Cancer Institute2021 to 2025$19,034,443July 1, 2007June 30, 2030REDDY, PAVANreporter.nih.gov
CWRU Center for Excellence on the Impact of Substance Use on HIVNIHNational Institute on Drug Abuse2021 to 2025$16,213,687September 15, 2021May 31, 2027LEVINE, ALAN DAVIDreporter.nih.gov
The Alzheimer's Disease Research Center at the University of California, IrvineNIHNational Institute on Aging2021 to 2025$16,032,156June 15, 2020March 31, 2030LAFERLA, FRANK Mreporter.nih.gov
The University of Kansas Cancer CenterNIHNational Cancer Institute2021 to 2025$13,943,269July 11, 2012June 30, 2027JENSEN, ROY A.reporter.nih.gov
Kynurenine accumulation drives loss of muscle and bone function with agingNIHNational Institute on Aging2021 to 2025$11,563,609May 1, 2011May 31, 2027ISALES, CARLOS M.reporter.nih.gov
COBRE in Human GeneticsNIHNational Institute of General Medical Sciences2021 to 2025$10,847,075February 10, 2021January 31, 2027MACKAY, TRUDY F.reporter.nih.gov
Molecular Vector and Conditional ES Cell Clone Collection Validation and Maintenance Plan by theMMRRC at UC DavisNIHOffice of the Director, National Institutes of Health2021 to 2025$10,759,343August 1, 2025January 31, 2026LLOYD, KC KENTreporter.nih.gov
Center for 3D Structure and Physics of the GenomeNIHNational Human Genome Research Institute2021 to 2024$9,564,360September 18, 2020June 30, 2026DEKKER, JOBreporter.nih.gov
Inherited T cell defects: Diagnosis, Mechanisms and TreatmentsNIHNational Institute of Allergy and Infectious Diseases2021 to 2024$9,040,281September 8, 2020August 31, 2025MARSON, ALEXANDERreporter.nih.gov
Therapeutic gene editing and multimodal imaging in juvenile macular degenerationNIHNational Eye Institute2021 to 2024$8,710,741June 1, 2020May 31, 2026TSANG, STEPHEN Hreporter.nih.gov
Multiscale Analyses of 4D Nucleome Structure and Function by Comprehensive Multimodal Data IntegrationNIHNational Human Genome Research Institute2021 to 2024$8,301,636September 22, 2020June 30, 2026MA, JIANreporter.nih.gov
Center of Biomedical Research Excellence in Matrix Biology Phase IINIHNational Institute of General Medical Sciences2021 to 2023$8,248,947August 1, 2014May 31, 2025OXFORD, JULIA THOMreporter.nih.gov
Rat Resource and Research CenterNIHOffice of the Director, National Institutes of Health2021 to 2025$7,587,318June 1, 2001April 30, 2026BRYDA, ELIZABETH Creporter.nih.gov
Parkinsons Disease Scalable iPSC Autologous Cell TherapyNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$7,528,144January 1, 2020December 31, 2025HALLETT, PENELOPE JANEreporter.nih.gov
IGF::OT::IGFEMMES NEIS-VNIHOffice of the Director, National Institutes of Health2021$7,315,897November 1, 2016October 31, 2021HAMMEL, KERIreporter.nih.gov
Exosomes as mediators of cardiac injury and repairNIHNational Heart, Lung, and Blood Institute2021 to 2025$7,022,243September 1, 2017June 30, 2029KISHORE, RAJreporter.nih.gov
Functional Interrogation of T2D-associated genes in human stem cell-derived models and miceNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2024$6,998,766August 20, 2020June 30, 2025SEALE, PATRICKreporter.nih.gov
FMRP-mediated Regulation in Human Brain Development and Therapeutic AdvancementNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2021 to 2024$6,546,370September 25, 2020June 30, 2025JIN, PENGreporter.nih.gov
From proteins to cells to tissues: A multi-scale assessment of biomechanical regulation by the myosin molecular motorNIHNational Institute of General Medical Sciences2021 to 2023$6,459,020May 15, 2019April 30, 2025BERNSTEIN, DANIELreporter.nih.gov
Molecular Circuits in the Hematopoietic Stem Cell NicheNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2024$6,422,507August 15, 2020May 31, 2025DALEY, GEORGE Qreporter.nih.gov
Metals and Metal Mixtures: Cognitive Aging, Remediation and Exposure Sources (MEMCARE)NIHNational Institute of Environmental Health Sciences2021 to 2024$6,396,550February 21, 2020May 9, 2025LU, QUANreporter.nih.gov
Development of PU.1 Inhibitory Modulators as Novel Therapeutics for Alzheimer's DiseaseNIHNational Institute on Aging2021 to 2024$6,353,055May 15, 2020April 30, 2026TSAI, LI-HUEIreporter.nih.gov
The second phase of NIH Common Fund 4D Nucleome Network Organizational HubNIHNational Cancer Institute2021 to 2024$6,160,327March 1, 2024August 31, 2024ZHONG, SHENGreporter.nih.gov
Integrating large scale genomics and functional studies to accelerate FSGS/NS discoveryNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2024$5,901,662August 15, 2020May 31, 2026POLLAK, MARTIN R.reporter.nih.gov
A regulome and transcriptome atlas of fetal and adult human neurogenesisNIHNational Institute of Mental Health2021$5,548,451September 20, 2021September 19, 2025ROUSSOS, PANAGIOTISreporter.nih.gov
Regulation of cellular pathways in human brain developmentNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$5,467,336July 1, 2014May 31, 2025ALVAREZ-BUYLLA, ARTUROreporter.nih.gov
Actin assembly and clathrin-mediated endocytosis in yeast and mammalsNIHNational Institute of General Medical Sciences2021 to 2025$5,442,792July 1, 2016June 30, 2026DRUBIN, DAVID Greporter.nih.gov
Center for Integrated Multi-modal and Multi-scale Nucleome ResearchNIHNational Human Genome Research Institute2021 to 2024$5,406,000September 24, 2020June 30, 2025REN, BINGreporter.nih.gov
A Human iPSC-based Cell Therapy for Canavan DiseaseNIHNational Institute of Neurological Disorders and Stroke2021 to 2023$5,276,950June 15, 2021May 31, 2027SHI, YANHONGreporter.nih.gov
The stromal microenvironment as a co-organizer of bladder carcinogenesis and progressionNIHNational Cancer Institute2023 to 2025$5,126,849September 22, 2022August 31, 2027CHAN, KEITH SYSONreporter.nih.gov
Trisomy 21 and its impact on hedgehog-dependent gene regulation and differentiation timingNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2023 to 2024$5,112,898September 1, 2024March 31, 2026MOSKOWITZ, IVAN PAULreporter.nih.gov
IND Enabling Studies for RASRx 1902, a novel Mas receptor agonist, for treatment of cognitive impairment in patients at risk for Alzheimer's disease.NIHNational Institute on Aging2021 to 2023$4,958,940May 1, 2020April 30, 2026RODGERS, KATHLEEN E.reporter.nih.gov
A Phase I Clinical Trial Testing Feasibility of Hematopoietic Stem Cell Gene Therapy Using Platelet Factor VIII to Safely Improve Hemostasis for Severe Hemophilia A with Inhibitory AntibodiesNIHNational Heart, Lung, and Blood Institute2021 to 2023$4,780,411April 5, 2019March 31, 2026WILCOX, DAVID ALLENreporter.nih.gov
Placental models to support embryogenesis in vitroNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2021 to 2024$4,662,000September 30, 2020July 31, 2026ZERNICKA-GOETZ, MAGDALENAreporter.nih.gov
Microphysiological systems to interrogate the Islet-Liver-Adipose Axis in normal physiology and Type-2 Diabetes MellitusNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2022$4,582,323September 20, 2018July 31, 2024STAHL, ANDREASreporter.nih.gov
Dynamics of chromosome organization and chromatin states in single cellsNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2024$4,544,908September 19, 2020June 30, 2025CAI, LONGreporter.nih.gov
Illuminating Function of the Understudied Druggable KinomeNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2022$4,503,990September 15, 2017December 31, 2024JOHNSON, GARY L.reporter.nih.gov
Early Pathogenesis of Cystic Fibrosis Related DiabetesNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2023$4,452,977April 30, 2021March 31, 2024ENGELHARDT, JOHN Freporter.nih.gov
Progenitor Regulation in Craniofacial Development and RegenerationNIHNational Institute of Dental & Craniofacial Research2021 to 2024$4,376,497September 14, 2017June 30, 2026CRUMP, GAGE Dreporter.nih.gov
UAB Childhood Cystic Kidney Disease Center (UAB-CCKDC)NIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2025$4,330,298July 20, 2020August 31, 2030YODER, BRADLEY K.reporter.nih.gov
Human Microphysiology Systems Disease Model of Type 2 Diabetes Starting with Liver and pancreatic IsletsNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2022$4,324,679September 20, 2018July 31, 2023TAYLOR, D. LANSINGreporter.nih.gov
Live-cell multiplex super-resolution imaging of chromatin state transitionsNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2024$4,225,012September 15, 2020June 30, 2026BINTU, LACRAMIOARAreporter.nih.gov
Development and Expansion of the Human Cerebral CortexNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$4,211,732December 1, 2016November 30, 2024KRIEGSTEIN, ARNOLDreporter.nih.gov
A generalizable framework for linking single-cell genomic states with cell fate outcomes in hematopoiesisNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2024$4,203,696August 15, 2020May 31, 2025GRIMES, H. LEIGHTONreporter.nih.gov
Small molecule targeting an epigenetic regulator for the treatment of osteoarthritisNIHNational Institute on Aging2021 to 2024$4,178,124September 30, 2021May 2, 2025ADORNO, MADDALENAreporter.nih.gov
Genome-Wide Discovery and Translational Research for Neural RepairNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$4,147,990December 1, 2016November 30, 2025STRITTMATTER, STEPHEN Mreporter.nih.gov
Generation of Novel Genetic Tools to Study Cellular Heterogeneity in Adipose TissuesNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2023$4,098,938July 17, 2019October 31, 2024SCHERER, PHILIPP Ereporter.nih.gov
Genetic neuroscience: How human genes and alleles shape neuronal phenotypesNIHNational Institute of Mental Health2021$4,026,586September 20, 2017July 31, 2023MCCARROLL, STEVEN ANDREWreporter.nih.gov
BIOREPOSITORY OF HUMAN INDUCED PLURIPOTENT STEM CELLSFORCARDIOVASCULAR DISEASES (BHIPSC-CVD)- TASK A. CORE STUDY OPERATIONSNIHNational Heart, Lung, and Blood Institute2021 to 2024$3,969,819September 1, 2020August 31, 2025WU, JOSEPHreporter.nih.gov
Cardiac lineage determination and nuclear architectureNIHNational Heart, Lung, and Blood Institute2021 to 2024$3,927,168January 1, 2018December 31, 2024EPSTEIN, JONATHAN A.reporter.nih.gov
Basic Investigation and Translational Applications Concerning the Cell and Molecular Biology of Blood and Vascular CellsNIHNational Heart, Lung, and Blood Institute2021 to 2024$3,926,545March 1, 2018February 28, 2026NEWMAN, PETER Jreporter.nih.gov
Imaging organ system interfaces in ischemic heart diseaseNIHNational Heart, Lung, and Blood Institute2021 to 2024$3,920,729February 1, 2018January 31, 2025NAHRENDORF, MATTHIASreporter.nih.gov
Study of cell-type specific Alzheimer's disease genetic variants using a novel bioengineered model of iPSC-derived neural tissueNIHNational Institute on Aging2021 to 2024$3,903,556May 1, 2020April 30, 2026TESCO, GIUSEPPINAreporter.nih.gov
Perturbing the LXR/SREBP axis to decipher protective and pathogenic AD/ADRD microglial phenotypesNIHNational Institute on Aging2024$3,840,870May 1, 2024April 30, 2027GLASS, CHRISTOPHER Kreporter.nih.gov
BMT Survivor Study-2 (BMTSS-2)NIHNational Cancer Institute2021 to 2023$3,811,745April 1, 2019March 31, 2025BHATIA, SMITAreporter.nih.gov
A two-pronged approach to generating novel models of photoreceptor degeneration for regenerative cell therapyNIHNational Eye Institute2021 to 2024$3,781,701September 30, 2021July 31, 2026FU, YINGBINreporter.nih.gov
Elucidating the Biological Differences Between Distinct Fibrillar and Non-Fibrillar Alpha-Synuclein Inclusions in Human Stem-Cell ModelsNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$3,706,946July 1, 2020April 30, 2026KHURANA, VIKRAMreporter.nih.gov
Research Program Award (R35 Clinical Trial Optional) - Dr. Robyn Klein NINDSNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$3,695,974May 1, 2021October 31, 2024CAIN, MATTHEW Dreporter.nih.gov
Molecular recording to predict cell fate decisions and animal behaviorNIHNational Institute of Mental Health2021$3,693,282August 1, 2021July 31, 2025MITRA, ROBI Dreporter.nih.gov
Cardiac Lineage-Specific Molecular Mechanisms of Heart FailureNIHNational Heart, Lung, and Blood Institute2021 to 2024$3,682,052February 1, 2021January 31, 2025CHI, NEIL Creporter.nih.gov
Cellular consequences and convergent biology of schizophrenia-associated rare variants in the diverse GPC cohortNIHNational Institute of Mental Health2022 to 2024$3,678,769August 1, 2022May 31, 2027MULLE, JENNIFER GLADYSreporter.nih.gov
1/2 Allogeneic Human Mesenchymal Stem Cell (MSC) Injection in Patients with Hypoplastic Left Heart Syndrome: A Phase IIb Clinical TrialNIHNational Heart, Lung, and Blood Institute2021 to 2024$3,521,212September 15, 2020August 31, 2025BERGER, STUARTreporter.nih.gov
Construction of an Integrated Immune - Vascular Brain - Chip as a Platform for the Study, Drug Screening, and Treatments of Alzheimer's DiseaseNIHNational Institute of Neurological Disorders and Stroke2021 to 2023$3,475,569September 20, 2019May 31, 2024TSAI, LI-HUEIreporter.nih.gov
Development of a Clinical Hemoglobin ModulatorNIHNational Heart, Lung, and Blood Institute2021 to 2022$3,473,811June 1, 2020May 31, 2024PERRINE, SUSAN PARKreporter.nih.gov
Immunobiology of Lung Injury and FibrosisNIHNational Heart, Lung, and Blood Institute2021 to 2024$3,455,443January 21, 2019December 31, 2024MOORE, BETHANY B.reporter.nih.gov
The MYC Transcription Factor Network and the Path to CancerNIHNational Cancer Institute2021 to 2024$3,449,610September 1, 2018August 31, 2025EISENMAN, ROBERT NEILreporter.nih.gov
Functional roles of genetic risk factors for brain disorders in neurogenesis and neurodevelopmentNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$3,437,163December 1, 2016November 30, 2024MING, GUO-LIreporter.nih.gov
Clonal expansion, resistance to efferocytosis and innate immunity in atherosclerosisNIHNational Heart, Lung, and Blood Institute2021 to 2024$3,398,319January 15, 2019December 31, 2024LEEPER, NICHOLAS JAMESreporter.nih.gov
Novel Network Biology Approaches to Reposition FDA-approved Drugs for Alzheimer's DiseaseNIHNational Institute on Aging2021 to 2024$3,386,194September 15, 2020May 31, 2026ZHANG, BINreporter.nih.gov
Microphysiological systems for modeling autoimmunity in type 1 diabetesNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2023$3,372,768August 2, 2019July 31, 2025STANGER, BEN Zreporter.nih.gov
Modulating Stochastic Gene Expression for Cell-fate Control and TherapeuticsNIHNational Institute of Allergy and Infectious Diseases2021 to 2024$3,366,623June 1, 2014August 10, 2024WEINBERGER, LEOR Sreporter.nih.gov
Genetic Control of Cardiac Development: Congenital Heart Disease Gene Discovery in DrosophilaNIHNational Heart, Lung, and Blood Institute2021 to 2024$3,338,929August 1, 1995June 30, 2025BODMER, ROLFreporter.nih.gov
Vascular smooth muscle cell heterogeneity and diseaseNIHNational Heart, Lung, and Blood Institute2021 to 2024$3,305,617March 1, 2021December 31, 2025SIMONS, MICHAELreporter.nih.gov
Enhancer-based Immune and Beta Cell Dysregulation Underlying T1D RiskNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2023$3,303,112September 15, 2020June 30, 2025SUH, YOUSINreporter.nih.gov
Identification of the active nuclear niche(s) using novel proteomic, genomic, transgenic, and live-cell microscopy technologiesNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2024$3,283,997September 15, 2020June 30, 2026BELMONT, ANDREW STEVENreporter.nih.gov
Retinal Ganglion Cell Replacement in Optic NeuropathiesNIHNational Eye Institute2021 to 2024$3,242,042September 30, 2018August 31, 2024GOLDBERG, JEFFREY Lreporter.nih.gov
Genetically Diverse Mouse Embryonic Stem Cells: A Platform for Cellular Systems GeneticsNIHOffice of the Director, National Institutes of Health2021 to 2024$3,241,681March 1, 2021May 31, 2025REINHOLDT, LAURA Greporter.nih.gov
Protecting colonic mucus to mitigate acute intestinal graft-versus-host diseaseNIHNational Heart, Lung, and Blood Institute2021 to 2024$3,218,917August 15, 2015June 30, 2026JENQ, ROBERTreporter.nih.gov
Cell specific delivery of novel therapies to enhance glomerular regeneration and repairNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2024$3,199,320September 1, 2020May 31, 2025SHANKLAND, STUART JAMESreporter.nih.gov
Technology-Enabled Activation of Skin Cancer Screening for Hematopoietic Cell Transplantation Survivors and their Primary Care ProvidersNIHNational Cancer Institute2021 to 2024$3,192,137April 1, 2020March 31, 2026ARMENIAN, SAROreporter.nih.gov
Isolation, characterization and translational development of glioma stem cellsNIHNational Cancer Institute2021 to 2023$3,189,696February 1, 2017January 31, 2025PARADA, LUIS FERNANDOreporter.nih.gov
Aging, Polypharmacy and Neurotoxicity in Adults Living with HIVNIHNational Institute on Aging2021 to 2024$3,183,836May 1, 2020February 28, 2026MA, QINGreporter.nih.gov
Next Generation Therapies for Fertility Preservation in Male Cancer PatientsNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2021 to 2024$3,165,939May 15, 2020April 30, 2025ORWIG, KYLE EDWINreporter.nih.gov
Ex Vivo Generation of Functional Kidney Tissues for TransplantationNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2024$3,161,308September 1, 2020May 14, 2025LEWIS, JENNIFER A.reporter.nih.gov
Modeling intestinal dysfunction in HIV infection with organoid technologyNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2024$3,127,465January 10, 2020December 31, 2025OTT, MELANIE MARIAreporter.nih.gov
Modeling diabetes using an integrated plate systemNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2022$3,092,998September 20, 2018July 31, 2024WELLS, JAMES Mreporter.nih.gov
Multimodal Analysis of Gestational Health and Placental Injury in Opioid-Affected PregnanciesNIHNational Institute on Drug Abuse2023$3,092,159August 15, 2023July 30, 2026OUYANG, YINGSHIreporter.nih.gov
ENCODE Mapping Center-A Comprehensive Catalog of DNase I Hypersensitive SitesNIHNational Human Genome Research Institute2021$3,086,945February 1, 2021January 31, 2023STAMATOYANNOPOULOS, JOHN Areporter.nih.gov
Therapeutic Anti-HIV Chimeric Antigen Receptors Via Stem Cell DeliveryNIHNational Institute of Allergy and Infectious Diseases2021 to 2024$3,081,124January 16, 2020December 31, 2024YANG, OTTO Oreporter.nih.gov
Harnessing natural stem cell-based strategies for mammalian dental renewalNIHNational Institute of Dental & Craniofacial Research2021 to 2023$3,080,448September 22, 2016June 30, 2024KLEIN, OPHIR Dreporter.nih.gov
Genetic determinants of 4D genome folding in human cardiac developmentNIHNational Heart, Lung, and Blood Institute2021 to 2024$3,069,960September 21, 2020August 31, 2025BRUNEAU, BENOIT GAETANreporter.nih.gov
Promoting Brain Resilience to Alzheimer's NeuropathologyNIHNational Institute on Aging2021 to 2024$3,062,659August 1, 2020April 30, 2026TAGLIALATELA, GIULIOreporter.nih.gov
Retinal Ganglion Cell Replacement in Clinically Relevant Models of Optic NeuropathyNIHNational Eye Institute2021 to 2022$3,026,491September 30, 2018August 31, 2024REX, TONIA Sreporter.nih.gov
Investigating the role of adipose tissue in mobility and aging (SOMMA-AT)NIHNational Institute on Aging2021 to 2024$3,021,652September 15, 2020May 31, 2025SPARKS, LAUREN MARIEreporter.nih.gov
Towards a better understanding of genetic architecture of Alzheimer's disease with human iPSC modelsNIHNational Institute on Aging2021 to 2024$3,018,880August 15, 2020April 30, 2026WEN, ZHEXINGreporter.nih.gov
A 3D vascularized islet biomimetic to model type 1 diabetesNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2023$3,017,660August 1, 2019January 31, 2025SANDER, MAIKEreporter.nih.gov
Therapeutic Implications of Molecular Defects in Bone Marrow FailureNIHNational Heart, Lung, and Blood Institute2021 to 2023$3,016,565January 12, 2017December 31, 2023MACIEJEWSKI, JAROSLAW P.reporter.nih.gov
Stem Cell Biology, Cancer Stem Cell Biology, and Cancer ImmunotherapyNIHNational Cancer Institute2021 to 2023$3,015,518September 21, 2017August 31, 2024WEISSMAN, IRVING L.reporter.nih.gov
Harnessing human brain and liver microphysiological systems for testing therapeutics for metastatic melanomaNIHNational Center for Advancing Translational Sciences2021 to 2022$3,003,024August 1, 2018July 31, 2024WIKSWO, JOHN PETERreporter.nih.gov
BRITE-Eye: An integrated discovery engine for CNS therapeutic targets driven by high throughput genetic screens, functional readouts in human neurons, and machine learningNIHNational Institute of Mental Health2023 to 2024$2,999,997September 19, 2023August 31, 2025WILLIAMS, LUIS ALBERTOreporter.nih.gov
Impact of peripheral nerves on mesenchymal cell fate in extremity traumaNIHNational Institute of Arthritis and Musculoskeletal and Skin Diseases2021 to 2024$2,991,689August 1, 2017April 30, 2026LEVI, BENJAMINreporter.nih.gov
Defining Genetic Architecture and Pathways of DCMNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,976,096April 1, 2005January 31, 2026SEIDMAN, JONATHAN Greporter.nih.gov
TREM2-mediated microglial dynamic function in Alzheimer diseaseNIHNational Institute on Aging2021 to 2024$2,968,448February 1, 2020December 31, 2025ZHAO, NAreporter.nih.gov
MIDAS: MIcroangiopathy, endothelial Damage in Adults undergoing Stem cell transplantationNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,957,506August 20, 2020July 31, 2026VASU, SUMITHIRAreporter.nih.gov
Defining disease mechanisms in SLC35A2 epilepsyNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$2,951,492July 1, 2020April 30, 2025HEINZEN, ERIN Lreporter.nih.gov
Defining the Mechanistic Basis for Neurofibromatosis-1 Nervous System Disease HeterogeneityNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$2,950,878December 1, 2016November 30, 2024GUTMANN, DAVID Hreporter.nih.gov
Extremely high-throughput mapping of protein, RNA, and chromatin interactions in health and diseaseNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2024$2,945,203July 30, 2020June 30, 2025ZHONG, SHENGreporter.nih.gov
Cell and Network Disruptions and Associated Pathogenenesis in Tauopathy and Down SyndromeNIHNational Institute on Aging2021 to 2024$2,943,744April 15, 2020March 31, 2026FINKBEINER, STEVEN Mreporter.nih.gov
Polyunsaturated fatty acids as anti-arrhythmic agents.NIHNational Heart, Lung, and Blood Institute2021 to 2024$2,942,029September 15, 2016March 31, 2026BARRO-SORIA, RENEreporter.nih.gov
Mechanistic Basis of Cardiac LaminopathyNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,934,243September 16, 2021June 30, 2026WORMAN, HOWARD Jreporter.nih.gov
Identifying Alzheimer’s Disease Causal Variants and Target Genes Using iPSC-derived MicrogliaNIHNational Institute on Aging2021 to 2024$2,922,756April 15, 2020March 31, 2025PHANSTIEL, DOUGLAS H.reporter.nih.gov
Origin and Function of Intra-epithelial Mast Cells in AsthmaNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,919,325April 1, 2021March 31, 2026HALLSTRAND, TEAL Sreporter.nih.gov
Induced neuronal cells: A novel tool to study neuropsychiatric diseasesNIHNational Institute of Mental Health2021 to 2024$2,918,957September 29, 2010August 31, 2025WERNIG, MARIUSreporter.nih.gov
Systematic Reconstruction of Epithelial-Mesenchymal Communication in Organ DevelopmentNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2021 to 2024$2,918,081August 15, 2021July 31, 2026LI, PULINreporter.nih.gov
Dissecting the role of NOTCH2NL genes in human brain development and neurological disorders associated with chromosome 1q21.1 distal duplications and deletions.NIHNational Institute of Mental Health2021 to 2024$2,907,904April 15, 2020January 31, 2026SALAMA, SOFIE REDAreporter.nih.gov
Investigating the effectiveness of COVID-19 testing choices, community engagement, and culturally-embedded mHealth literacy delivery in a medically-underserved, community-based sampleNIHNational Institute of Environmental Health Sciences2021 to 2022$2,906,922November 11, 2020July 31, 2023AL-HENDY, AYMANreporter.nih.gov
Extracellular Vesicle treatment and age-related neuropathology in non-human primatesNIHNational Institute on Aging2021 to 2024$2,902,850September 15, 2020April 30, 2026MOORE, TARA Lreporter.nih.gov
Retinal disease models for translational photoreceptor replacementNIHNational Eye Institute2021 to 2022$2,898,123September 30, 2018May 31, 2025WOLFE, JOHN Hreporter.nih.gov
Study the Protective Roles of ApoE2 in Alzheimer's Disease Using Reprogrammed Isogenic CellsNIHNational Institute on Aging2021 to 2024$2,897,144May 1, 2020March 31, 2025HUANG, YADONGreporter.nih.gov
Higher Precision Human and Mouse TranscriptomesNIHNational Human Genome Research Institute2021$2,888,702February 1, 2017January 31, 2023WOLD, BARBARA Jreporter.nih.gov
Implementing a coupled system of integrative ML modeling and data validation for elucidating microglial therapeutic targets in neurodegenerative diseaseNIHNational Institute of Mental Health2023 to 2024$2,885,988September 15, 2023August 31, 2025SACHS, KARENreporter.nih.gov
The Pathogenesis of RNA Splicing Factor Associated Retinal DegenerationNIHNational Eye Institute2021 to 2024$2,874,308April 1, 2011March 31, 2026PIERCE, ERIC Areporter.nih.gov
Using donor dendritic cells to optimize GvHD and GvL in allogeneic stem cell transplantationNIHNational Institute of Allergy and Infectious Diseases2021 to 2024$2,867,908June 1, 2020May 31, 2026WALLER, EDMUND Kreporter.nih.gov
Translational assessment of brain bioenergetic function in schizophreniaNIHNational Institute of Mental Health2021 to 2024$2,863,277December 1, 2019October 31, 2025MARANO, CHRISTOPHERreporter.nih.gov
Phenotyping Genetic Disorders of Hepatic Lipid and Lipoprotein Metabolism in Cells, Mice, and MenNIHNational Heart, Lung, and Blood Institute2021 to 2023$2,861,646January 1, 2017December 31, 2024GINSBERG, HENRY Nreporter.nih.gov
Single Cell Transciptomics of the Opioid Use Disorder and HIV Syndemic in the Human BrainNIHNational Institute on Drug Abuse2022 to 2024$2,859,989September 1, 2022August 31, 2025CHENG, CHRISTINEreporter.nih.gov
DROSOPHILA GENOMICS RESOURCE CENTERNIHOffice of the Director, National Institutes of Health2021 to 2025$2,858,854April 1, 2002March 31, 2029ZELHOF, ANDREWreporter.nih.gov
Quantitative Multiparametric MRI to Assess the Effect of Stem Cell Therapy on Chronic Low Back PainNIHNational Institute of Arthritis and Musculoskeletal and Skin Diseases2021 to 2024$2,858,064August 1, 2014July 31, 2025LI, DEBIAOreporter.nih.gov
Molecular regulation of native hematopoiesisNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,856,222February 15, 2016December 31, 2025CAMARGO, FERNANDOreporter.nih.gov
Function of NeurexinsNIHNational Institute of Mental Health2021 to 2024$2,855,805September 30, 1994February 28, 2025SUDHOF, THOMAS C.reporter.nih.gov
Adoptive T Lymphocyte Administration for Chronic Norovirus Treatment Following Hematopoietic Stem Cell TransplantationNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,855,157May 1, 2020April 30, 2026KELLER, MICHAEL DANIELreporter.nih.gov
Wnt signaling in hematopoietic developmentNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,849,578January 1, 2017June 30, 2025WILLERT, KARL Hreporter.nih.gov
Beyond the Barrier: Alveolar Epithelial Cell Biology in Health and DiseaseNIHNational Heart, Lung, and Blood Institute2021 to 2023$2,844,000August 15, 2021June 30, 2025BOROK, ZEAreporter.nih.gov
HEMANGIOBLAST DEVELOPMENT AND REGULATIONNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,843,107August 1, 1996May 31, 2026CHOI, KYUNGHEEreporter.nih.gov
JAK-STAT Control of Zika Virus-Induced Fetal InjuryNIHNational Institute of Allergy and Infectious Diseases2021 to 2023$2,840,817July 1, 2019June 30, 2025ADAMS WALDORF, KRISTINA M.reporter.nih.gov
Developing Cone-Dominant Retinal Disease Models as a Resource for Translational Vision ResearchNIHNational Eye Institute2021 to 2022$2,820,106September 30, 2018August 31, 2022CARROLL, JOSEPHreporter.nih.gov
Elucidating a microgliaassociated role for SORLA in modulating AD pathogenesisNIHNational Institute on Aging2022$2,818,493August 1, 2022July 31, 2025HUANG, TIMOTHY YIKAIreporter.nih.gov
Mechanisms of HIV-associated epithelialintestinal stem cell (ISC) dysfunctionNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2024$2,811,833July 1, 2020June 30, 2025KWON, DOUGLASreporter.nih.gov
Impact of particle and ozone inhalation co-exposure on alveolar epithelial regenerationNIHNational Institute of Environmental Health Sciences2021 to 2024$2,799,613May 1, 2020February 28, 2026HUSSAIN, SALIKreporter.nih.gov
Discovery of diabetes-relevant β cell enhancers through 4D enhancer mapping, integrative analysis, and large-scale CRISPRi perturbation screensNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2024$2,792,424September 15, 2020June 30, 2025HUANGFU, DANWEIreporter.nih.gov
Polymer Scaffolds for Mandibular Condyle Cartilage RegenerationNIHNational Institute of Dental & Craniofacial Research2021 to 2024$2,788,930December 1, 2020November 30, 2025ALMARZA, ALEJANDRO JOSEreporter.nih.gov
Elastic, Degradable Vascular Grafts with Helical MicrofibersNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,787,042August 15, 2021July 31, 2025WANG, YADONGreporter.nih.gov
Cardiovascular reserve capacity in survivors of hematopoietic cell transplantationNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,785,889February 1, 2020January 31, 2026ARMENIAN, SAROreporter.nih.gov
Bioactive Scaffold for TMJ Disc Regeneration by Endogenous Stem/Progenitor CellsNIHNational Institute of Dental & Craniofacial Research2021 to 2024$2,782,994August 11, 2020July 31, 2026LEE, CHANG HUNreporter.nih.gov
Intraosseous delivery of lentiviral vectors for hemophilia A gene therapyNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,777,901August 15, 2016June 30, 2026MIAO, CAROL Hreporter.nih.gov
Genotype-guided therapy for atrial fibrillationNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,771,945July 15, 2020June 30, 2026DARBAR, DAWOODreporter.nih.gov
Combined Cardiomyopathy, e.g., of Cancer Chemotherapeutics, and Proarrhythmia for Cardiotoxicity Clinical Trials-in-a-Dish (CTiD) with iPSC-Derived CardiomyocytesNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,764,144June 1, 2021July 31, 2025PRICE, JEFFREY H.reporter.nih.gov
Defining mechanisms of aortic root aneurysm in Loeys-Dietz syndrome using patients’ induced pluripotent stem cells and genome editingNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,760,413May 1, 2020April 30, 2026YANG, BOreporter.nih.gov
Common Stem Cell of Origin for Junctional and Gastric AdenocarcinomaNIHNational Cancer Institute2022 to 2024$2,754,572September 15, 2022August 31, 2027MCKEON, FRANK D.reporter.nih.gov
Clinical and Molecular Heterogeneity in the Myelodysplastic SyndromesNIHNational Cancer Institute2021 to 2024$2,742,067April 1, 2020March 31, 2025PARK, CHRISTOPHER Yreporter.nih.gov
Ethnically Diverse iPSC-Cardiomyocyte Panel for Pharmacogenomics and Drug Safety TestingNIHNational Heart, Lung, and Blood Institute2023 to 2024$2,741,939September 5, 2023August 31, 2025AHMED, SYED MUKHTARreporter.nih.gov
Sex-specific Molecular Profiling to Understand Pathology and Identify Causal Genes and Drug Targets for Alzheimer's DiseaseNIHNational Institute on Aging2021$2,740,705September 30, 2021August 31, 2024SUNG, YUNJUreporter.nih.gov
Development of FAST-DOSE assay system for the rapid assessment of acute radiation exposure, individual radiosensitivity and injury in victims for a large-scale radiological incidentNIHNational Institute of Allergy and Infectious Diseases2021 to 2024$2,738,709February 1, 2020January 31, 2026TURNER, HELEN Creporter.nih.gov
Synergistic Mechanisms of chronic Innate Immune Activation in Microglia by Opiates and HIV InfectionNIHNational Institute on Drug Abuse2021 to 2024$2,732,942July 15, 2020April 30, 2026GUMMULURU, SURYARAMreporter.nih.gov
Conformal Total Body and Marrow Irradiation for LeukemiaNIHNational Cancer Institute2021 to 2024$2,727,228September 13, 2011December 31, 2025HUI, SUSANTA Kreporter.nih.gov
Charting the 3D epigenome in human brain development and diseasesNIHNational Institute on Drug Abuse2021 to 2024$2,724,871September 30, 2020August 31, 2025SHEN, YINreporter.nih.gov
Adaptive epigenetic mechanisms of beta and immune cells in autoimmune diabetesNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2024$2,708,550July 15, 2021June 30, 2025HEROLD, KEVAN Creporter.nih.gov
Epigenetic Profiling of circulating cell-free DNA for the Monitoring of Graft-Versus-Host Disease after Hematopoietic Cell TransplantationNIHNational Institute of Allergy and Infectious Diseases2021 to 2024$2,694,538January 13, 2020December 31, 2025DE VLAMINCK, IWIJNreporter.nih.gov
Enhancing Innate Immune Reconstitution Post Allogeneic HSCT.NIHNational Heart, Lung, and Blood Institute2021 to 2024$2,685,463September 1, 2021June 30, 2025SERODY, JONATHAN S.reporter.nih.gov
1/7 Collaborative Genomic Studies of Tourette Disorder.NIHNational Institute of Mental Health2021 to 2023$2,683,588June 15, 2018March 31, 2025HEIMAN, GARY A.reporter.nih.gov
In vivo CRISPR engineering of B cells to produce anti-HIV broadly neutralizing antibodies using novel nanoparticlesNIHNational Institute of Allergy and Infectious Diseases2022 to 2024$2,680,549June 8, 2022April 1, 2025ADAIR, JENNIFER EILEENreporter.nih.gov
Transcriptional condensates, epigenetic editing and Rett SyndromeNIHNational Institute of Mental Health2021 to 2023$2,677,396September 15, 2014July 31, 2025JAENISCH, RUDOLFreporter.nih.gov
Metabolic Control of Stemness in lung epithelial progenitors by FAM13ANIHNational Heart, Lung, and Blood Institute2021 to 2024$2,676,003April 1, 2015November 30, 2025ZHOU, ANNY XIAOBOreporter.nih.gov
How the 3D Architecture of the Brain Shapes Cancer Cell Fate DecisionsNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$2,670,000September 30, 2021August 31, 2026FILBIN, MARIELLA GRUBERreporter.nih.gov
Exploiting the VISTA Pathway to Prevent Acute GVHD and Control Steroid Refractory DiseaseNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,663,582February 15, 2021January 31, 2026BLAZAR, BRUCE Rreporter.nih.gov
Transcriptional Control During ErythropoiesisNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2024$2,660,464September 16, 2013October 31, 2025RANISH, JEFFREY Areporter.nih.gov
Molecular pathobiology of soluble TREM2 in Alzheimer's diseaseNIHNational Institute on Aging2023$2,655,773April 1, 2017August 31, 2026HUANG, TIMOTHY YIKAIreporter.nih.gov
Genomics of bone and body composition traits in childrenNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2021 to 2024$2,651,635August 7, 2020June 30, 2026ZEMEL, BABETTE Sreporter.nih.gov
Modulating intrinsic beta cell stress to block diabetes pathogenesisNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2024$2,648,788August 15, 2021June 30, 2025PAPA, FEROZ Rreporter.nih.gov
Neuronal cell-cycle re-entry and neurodegenerationNIHNational Institute on Aging2021 to 2024$2,635,489August 15, 2020May 31, 2025SOCKANATHAN, SHANTHINIreporter.nih.gov
Regulation of Craniofacial Development by ALX Transcription FactorsNIHNational Institute of Dental & Craniofacial Research2021 to 2024$2,632,904September 9, 2020August 31, 2025JIANG, RULANGreporter.nih.gov
Comparative Genomics of Precursor Diversity and FunctionNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$2,631,720April 1, 2021February 28, 2026HAYDAR, TARIK Freporter.nih.gov
Defining Characteristics of Cortical Progenitor Cells over Time in Mouse and HumanNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$2,620,540December 15, 2016November 30, 2025TEMPLE, SALLYreporter.nih.gov
An Integrated In Vitro 3D Model of Human Bone Marrow and Peripheral InfectionNIHNational Institute of Biomedical Imaging and Bioengineering2021 to 2024$2,620,380September 15, 2021May 31, 2026GEORGE, STEVEN CARLreporter.nih.gov
The role of the nucleolus in human genome organization in normal and disease statesNIHNational Cancer Institute2021 to 2024$2,619,610September 21, 2020August 31, 2025KAUFMAN, PAUL D.reporter.nih.gov
Contributions of cell type and exosome signaling to prodromal synaptic and circuit changes in Alzheimer's Disease modelsNIHNational Institute on Aging2022$2,618,631August 15, 2022July 31, 2025CLINE, HOLLIS T.reporter.nih.gov
In Vivo Hematopoietic Stem Cell Gene Therapy of Beta-Thalassemia and Sickle Cell DiseaseNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,618,613June 1, 2016July 31, 2025LIEBER, ANDRE MICHAELreporter.nih.gov
Synthetic gene sensors and effectors to redirect organoid developmentNIHNational Institute of Biomedical Imaging and Bioengineering2021 to 2024$2,608,452May 1, 2021July 31, 2025WEISS, RONreporter.nih.gov
Development of 211Astatine-Conjugated Anti-CD45 Antibody-Based Conditioning for Hematopoietic Stem Cell Gene Therapy and EditingNIHNational Heart, Lung, and Blood Institute2021 to 2023$2,608,434May 15, 2020April 30, 2026WALTER, ROLAND BRUNOreporter.nih.gov
REGULATION OF HEMATOPOIETIC PROGENITORS BY DE NOVO DNA METHYLATIONNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2024$2,607,321July 1, 2011March 31, 2026GOODELL, MARGARET A.reporter.nih.gov
Intravital analysis of hematopoietic stem cells in their bone marrow niche - Resubmission - 1NIHNational Heart, Lung, and Blood Institute2021 to 2024$2,607,213September 20, 2021August 31, 2025REIZIS, BORISreporter.nih.gov
Pharmacologic Lysosomal Flux Activators to Ameliorate Alzheimer's Disease and Related DementiasNIHNational Institute on Aging2021$2,601,749September 1, 2021August 31, 2024KELLY, JEFFERY Wreporter.nih.gov
NATIONAL BIOREPOSITORY OF LUNG DISEASE-SPECIFIC HUMAN INDUCED PLURIPOTENT STEM CELLS:THE PURPOSE OF THIS RESOURCE IS TO BUILD AND SUPPORT A CRITICALNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,600,000May 1, 2020April 30, 2025N/A, N/Areporter.nih.gov
Probing the Cardiac PGC-1 Regulatory CascadeNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,593,540April 1, 1998March 31, 2025KELLY, DANIEL PATRICKreporter.nih.gov
SINGLE-CELL CHEMICAL TRANSCRIPTOMIC DISSECTION OF AN ESSENTIAL TRANSCRIPTION FACTOR NETWORKNIHNational Human Genome Research Institute2021 to 2024$2,587,499November 4, 2021August 31, 2026RAMANI, VIJAYreporter.nih.gov
Synthetic organogenesis: new paradigms in reconstituting human organ development in vitroNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2021 to 2024$2,586,456September 21, 2021August 31, 2026SIMUNOVIC, MIJOreporter.nih.gov
Elucidating electrical stimulation induced non-neuronal activity using emerging in vivo imaging technology and electrophysiologyNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$2,585,973September 30, 2020June 30, 2025KOZAI, TAKASHI DANIEL YOSHIDAreporter.nih.gov
Control of the 4D chromatin landscape underlying gene activity during developmentNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2024$2,584,805September 17, 2020June 30, 2025GREGOR, THOMASreporter.nih.gov
Rectifying splicing mutations in blood disorders by gene editingNIHNational Heart, Lung, and Blood Institute2021 to 2023$2,584,045December 20, 2019November 30, 2023BAUER, DANIEL EVANreporter.nih.gov
Pediatric Heart Disease: Getting from Mutations to TherapeuticsNIHNational Heart, Lung, and Blood Institute2021 to 2023$2,582,324February 15, 2017January 31, 2025GELB, BRUCE Dreporter.nih.gov
Targeted genetic engineering of B cells to induce protective antibody responses to viral pathogensNIHNational Institute of Allergy and Infectious Diseases2022 to 2024$2,577,835July 5, 2022June 30, 2027ADAIR, JENNIFER EILEENreporter.nih.gov
Identifying cell type-specific autonomous and non-autonomous interactions in ADNIHNational Institute on Aging2022$2,567,371May 1, 2022April 30, 2025MENON, VILASreporter.nih.gov
The role of mTOR signaling in oligodendrocyte differentiation and CNS myelinationNIHNational Institute of Neurological Disorders and Stroke2021 to 2023$2,564,330September 30, 2012July 31, 2025MACKLIN, WENDY Breporter.nih.gov
Neuronal excitability and copy number variation disordersNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$2,563,265September 1, 2020May 31, 2026PENZES, PETERreporter.nih.gov
The Use of Senolytic and Anti-Fibrotic Agents to Improve the Beneficial Effect of Bone Marrow Stem Cells for OsteoarthritisNIHNational Institute of Arthritis and Musculoskeletal and Skin Diseases2021 to 2024$2,563,053August 1, 2020July 31, 2025HUARD, JOHNNYreporter.nih.gov
Cellular models of fetal neurodevelopment in maternal SARS-CoV-2 infectionNIHNational Institute of Mental Health2022$2,560,905September 15, 2022September 14, 2025EDLOW, ANDREA GOLDBERGreporter.nih.gov
Molecular Basis of Gene Regulation by Polycomb Repressive Complex 2NIHNational Institute of General Medical Sciences2021 to 2024$2,560,793April 1, 2020March 31, 2026LIU, XINreporter.nih.gov
Activity-dependent Regulation of the Choroid Plexus-Cerebrospinal Fluid Stem Cell NicheNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$2,559,641May 15, 2014April 30, 2026LEHTINEN, MARIAreporter.nih.gov
Biomarker discovery for parkinsonian diseases in extracellular vesicles from iPSC-derived neuronsNIHNational Institute of Neurological Disorders and Stroke2023 to 2024$2,555,369April 1, 2023March 31, 2026BITAN, GALreporter.nih.gov
Vascular networks genetically engineered for protein drug deliveryNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,552,882August 15, 2015April 30, 2026MELERO-MARTIN, JUAN Mreporter.nih.gov
Three-dimensional conformation changes associated with T cell memory and autoimmunityNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2024$2,550,277September 15, 2020June 30, 2025HAWKINS, RAYMOND DAVIDreporter.nih.gov
A Human iPSC-Based Chimeric Mouse Model of Alzheimers Disease in Down SyndromeNIHNational Institute on Aging2021 to 2024$2,549,299September 30, 2021August 31, 2026JIANG, PENGreporter.nih.gov
Phase1/2a Clinical Trial of RPESC-derived RPE Transplantation as Therapy for Non-exudative Age-related Macular DegenerationNIHNational Eye Institute2021 to 2024$2,549,156September 30, 2020September 29, 2025STERN, JEFFREY Hreporter.nih.gov
Tissue chips for precision treatment of catecholaminergic polymorphic ventricular tachycardiaNIHNational Center for Advancing Translational Sciences2022 to 2024$2,546,193September 1, 2020July 31, 2025PU, WILLIAM TSWENCHINGreporter.nih.gov
The Molecular Regulation of Horizontal Basal Cell Activation in the Olfactory EpitheliumNIHNational Institute on Deafness and Other Communication Disorders2021 to 2024$2,546,159February 7, 2020January 31, 2026SCHWOB, JAMES E.reporter.nih.gov
Functional roles of lymphatics in organogenesis and tissue repairNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,543,362January 7, 2021December 31, 2025OLIVER, GUILLERMO Creporter.nih.gov
1/2 Cell Type and Region-Specific Regulatory Networks in Human Brain Development and DisordersNIHNational Institute of Mental Health2021 to 2022$2,541,620July 6, 2018March 31, 2024SESTAN, NENADreporter.nih.gov
Cellular and Molecular Analysis of the Psychiatric Risk Gene Transcription Factor 4 (TCF4)NIHNational Institute of Mental Health2021 to 2024$2,540,401September 2, 2016May 31, 2026MAHER, BRADY Jreporter.nih.gov
Investigating Pathogenic Mechanisms of Frontotemporal Dementia Caused by Mutations in CHMP2B and TBK1NIHNational Institute of Neurological Disorders and Stroke2021 to 2024$2,537,267January 1, 2018November 30, 2025GAO, FEN-BIAOreporter.nih.gov
Gaining insight into psychiatric disease by engineering piece by piece the human brain in vitro.NIHNational Institute of Mental Health2021 to 2024$2,536,379August 1, 2015May 31, 2025PASCA, SERGIUreporter.nih.gov
Prevention of pelvic floor muscle dysfunction with extracellular matrix hydrogelNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2021 to 2024$2,535,698September 30, 2020June 30, 2026ALPERIN, MARIANNAreporter.nih.gov
Methamphetamine Effect on HIV PersistenceNIHNational Institute on Drug Abuse2021 to 2024$2,535,677July 1, 2020May 31, 2025KAUL, MARCUSreporter.nih.gov
Joint Program in Molecules, Cells, and OrganismsNIHNational Institute of General Medical Sciences2021 to 2024$2,531,890July 1, 2020June 30, 2025D'SOUZA, VICTORIA MANUELreporter.nih.gov
Regulation of emergency hematopoiesis by the ubiquitin-proteasome systemNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,530,317September 1, 2021May 31, 2025BUSINO, LUCAreporter.nih.gov
Randomized study of low versus moderate dose busulfan in transplant for severe combined immunodeficiencyNIHNational Institute of Allergy and Infectious Diseases2021 to 2023$2,529,105August 24, 2017July 31, 2024WAYNE, ALAN S.reporter.nih.gov
Improving transfusion therapy for patients with sickle cell disease with pluripotent stem cell-derived red cellsNIHNational Heart, Lung, and Blood Institute2021 to 2022$2,528,360September 15, 2016May 31, 2025CHOU, STELLA Treporter.nih.gov
Modeling, pathogenesis and treatment of idiopathic pulmonary fibrosisNIHNational Heart, Lung, and Blood Institute2021 to 2022$2,527,128September 20, 2016May 31, 2025SNOECK, HANS-WILLEM Ereporter.nih.gov
The Genetic Architecture of Human Facial MorphologyNIHNational Institute of Dental & Craniofacial Research2021 to 2024$2,521,882July 14, 2017February 28, 2026WEINBERG, SETH Mreporter.nih.gov
Targeting the Metabolic Regulator SIRT5 in Acute Myeloid LeukemiaNIHNational Cancer Institute2021 to 2024$2,518,197July 1, 2020June 30, 2025DEININGER, MICHAEL W.reporter.nih.gov
Prenatal Origins of Neurometabolic ConsequencesNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2021 to 2024$2,517,422September 1, 2021July 31, 2026DEVASKAR, SHERIN Ureporter.nih.gov
Neuronal activity-responsive DNA repair mechanisms and cognitive agingNIHNational Institute on Aging2024$2,516,316September 1, 2024August 31, 2027GREENBERG, MICHAEL ELDONreporter.nih.gov
Novel mechanisms of obliterative pulmonary vascular remodeling and severe pulmonary arterial hypertensionNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,512,001July 1, 2016May 31, 2026ZHAO, YOU-YANGreporter.nih.gov
Molecular and Cellular Dissection of the Pathogenesis of Herpes Simplex Encephalitis with iPSC-Derived CNS and PNS CellsNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$2,509,626September 20, 2010March 31, 2025CASANOVA, JEAN-LAURENTreporter.nih.gov
Uncovering the role for MSI2 network in hematopoietic stem cellsNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2024$2,505,616September 15, 2014June 30, 2025KHARAS, MICHAELreporter.nih.gov
Editing Alveolar Progenitor Cells for Correction of Monogenic DiseaseNIHNational Heart, Lung, and Blood Institute2021 to 2022$2,504,499September 23, 2016May 31, 2025WHITSETT, JEFFREY Areporter.nih.gov
Targeting Aldehyde Dehydrogenase for Cancer PreventionNIHNational Cancer Institute2021 to 2024$2,499,798April 15, 2020March 31, 2026ROBERTSON, GAVIN P.reporter.nih.gov
Fine-scale Spatiotemporal Mapping of Cellular Regulatory Networks Directing Heart DevelopmentNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2021 to 2024$2,499,248August 1, 2020July 31, 2025CHI, NEIL Creporter.nih.gov
Single-cell dissection of chromatin architecture mechanisms connecting pathologic instability and transcriptional silencingNIHNational Institute on Drug Abuse2021 to 2024$2,498,183September 30, 2020August 31, 2025PHILLIPS-CREMINS, JENNIFER ELIZABETHreporter.nih.gov
Beyond Gene Dosage: Understanding Down Syndrome via 4D Genome OrganizationNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,496,816September 18, 2020August 31, 2025LI, WENBOreporter.nih.gov
Brain cPLA2 as a mechanism for neuroinflammation in AD/ADRD with and without APOE4 Diversity SupplementNIHNational Institute on Aging2022 to 2024$2,493,260May 15, 2022April 30, 2025YASSINE, HUSSEIN Nreporter.nih.gov
Using a SMART Design to Optimize PTSD Symptom Management Strategies Among Cancer SurvivorsNIHNational Cancer Institute2021 to 2024$2,482,100December 1, 2019November 30, 2025SMITH, SOPHIA K.reporter.nih.gov
Defining the pathogenic relationship of TDP-43 inclusions and cytoplasmic double stranded RNA in AD and FTDNIHNational Institute on Aging2022$2,481,834August 2, 2022July 31, 2025ALBERS, MARK Wreporter.nih.gov
Epigenetics and 3D Structure of miR-10b/HoxD Locus in the Brain and Malignant GliomaNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$2,479,682September 15, 2020July 31, 2025KRICHEVSKY, ANNA M.reporter.nih.gov
Developing a patient-specific organoid model of pulmonary fibrosis using iPSCsNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,476,283December 15, 2020November 30, 2025KOTTON, DARRELL N.reporter.nih.gov
Personalizing Class I anti-Arrhythmic Drug TherapyNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,473,840April 1, 2020March 31, 2026SILVA, JONATHAN Rreporter.nih.gov
HIV, Methamphetamine and Human iPSC-derived Microglia-containing Cerebral OrganoidsNIHNational Institute on Drug Abuse2021 to 2024$2,470,488July 1, 2020April 30, 2026HO, WENZHEreporter.nih.gov
Lung leukocytes promote alveolar epithelial regeneration after severe injuryNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,469,157May 1, 2020April 30, 2026ARPAIA, NICHOLASreporter.nih.gov
Dissecting the role of the dentate gyrus microcircuit to improve cognitive discrimination in aging and Alzheimer's DiseaseNIHNational Institute on Aging2023$2,467,494December 15, 2022November 30, 2025LOSONCZY, ATTILAreporter.nih.gov
Regulation of endothelial cell specificationNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,466,084February 15, 2021January 31, 2025PU, WILLIAM TSWENCHINGreporter.nih.gov
Characterizing Emerging Humanized Immune Mouse Models for the study of transplant rejection and infectious disease pathology (Epstein Barr Virus)NIHNational Institute of Allergy and Infectious Diseases2021 to 2023$2,464,113February 2, 2021August 30, 2024BROWN, MATTHEW Ereporter.nih.gov
Mechanism of transplanted neonatal cardiac progenitor cells to repair ischemic myocardiumNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,462,741April 20, 2014August 31, 2025SCHUMACKER, PAUL Treporter.nih.gov
Brain lymphatic activation for craniosynostosis and Alzheimer’s diseaseNIHNational Institute of Neurological Disorders and Stroke2024$2,461,369June 1, 2024May 31, 2027CHEN, JIANFUreporter.nih.gov
Identifying pathways required for integration of kidney organoid and host epitheliaNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2024$2,461,009September 1, 2020May 31, 2025DRUMMOND, IAIN A.reporter.nih.gov
Integrative Modeling of HIV-Associated Neurocognitive Disorder in Human Brain OrganoidsNIHNational Institute on Drug Abuse2021 to 2024$2,456,170August 1, 2020May 31, 2025NOVITCH, BENNETT Greporter.nih.gov
Characterization of Neural Stem Cells in Adult BrainNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$2,454,507April 1, 1990March 31, 2026ALVAREZ-BUYLLA, ARTUROreporter.nih.gov
Biochemistry of Leukemia Virus Core-Binding FactorNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,451,198August 10, 1993June 30, 2025SPECK, NANCYreporter.nih.gov
Emergency Myelopoiesis Pathways in the Control of Blood ProductionNIHNational Heart, Lung, and Blood Institute2021 to 2023$2,450,418April 1, 2017March 31, 2025PASSEGUE, EMMANUELLEreporter.nih.gov
Role of central and peripheral immune crosstalk in FTD-Grn neurodegenerationNIHNational Institute of Neurological Disorders and Stroke2022$2,446,942August 17, 2022July 30, 2025TANSEY, MARIA DE LOURDES GAMEZreporter.nih.gov
Higher Order Chromatin and Genetic Risk for SchizophreniaNIHNational Institute of Mental Health2021 to 2023$2,446,779January 15, 2015July 31, 2025AKBARIAN, SCHAHRAMreporter.nih.gov
Humanized Mouse Avatars for T1DNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2023$2,439,759September 25, 2014May 31, 2024GREINER, DALE LESLIEreporter.nih.gov
Tomotherapy and Hematopoietic Stem Cells for Tolerance to Kidney TransplantsNIHNational Institute of Allergy and Infectious Diseases2021 to 2022$2,439,463August 1, 2012April 30, 2024KAUFMAN, DIXON Breporter.nih.gov
Machine learning with immunogenetics for the prediction of hematopoietic cell transplant outcomesNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,438,515January 5, 2021December 31, 2025HSU, KATHARINE Creporter.nih.gov
Cell-Type Specific Vulnerability to Tauopathy and Its Prevention in Multiple ModelsNIHNational Institute of Neurological Disorders and Stroke2021$2,438,130February 1, 2021January 31, 2024SIGURDSSON, EINAR Mreporter.nih.gov
The effects of PD-1 on tumor-mediated “emergency” myelopoiesis and fate commitment of myeloid cells: Implications for anti-tumor immunityNIHNational Cancer Institute2021 to 2024$2,436,646February 10, 2020January 31, 2026BOUSSIOTIS, VASSILIKI Areporter.nih.gov
BMP2 Regulation of Periosteal FunctionNIHNational Institute of Arthritis and Musculoskeletal and Skin Diseases2021 to 2024$2,436,018August 1, 2020April 30, 2026ROSEN, VICKIreporter.nih.gov
A Gata456 Pipeline of DiscoveryNIHNational Heart, Lung, and Blood Institute2021 to 2023$2,432,169January 10, 2017December 31, 2023EVANS, TODD Rreporter.nih.gov
Stem cells for therapeutics discovery in genetic blood disordersNIHNational Heart, Lung, and Blood Institute2021 to 2022$2,429,809September 23, 2016May 31, 2025DALEY, GEORGE Qreporter.nih.gov
Function of Putative Determinant in HematopoiesisNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2024$2,418,427August 1, 1993June 30, 2026BIEKER, JAMES Jreporter.nih.gov
The role of mitochondria in hematopoietic stem cell self-renewalNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,417,109January 1, 2021December 31, 2024FILIPPI, MARIE-DOMINIQUEreporter.nih.gov
Role of O-GlcNAcome on Breast Cancer Initiating CellsNIHNational Cancer Institute2021 to 2024$2,414,370March 1, 2020February 28, 2025REGINATO, MAURICIO J.reporter.nih.gov
Mathematical ecology models of host-microbiota interaction in auto microbiota transplants (auto-FMT)NIHNational Institute of Allergy and Infectious Diseases2021 to 2023$2,414,163February 1, 2019January 31, 2024XAVIER, JOAOreporter.nih.gov
Novel tools for in vitro electrophysiology and neurotrauma modelingNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$2,414,021August 17, 2020January 31, 2026FINAN, JOHN Dreporter.nih.gov
Gene regulatory networks for heart developmentNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,410,652January 1, 2021December 31, 2025BRUNEAU, BENOIT GAETANreporter.nih.gov
Alzheimer's disease-specific extracellular vesicles: from pathology to novel biomarker discoveryNIHNational Institute on Aging2023$2,399,582September 1, 2023August 31, 2026MACHAIRAKI, VASILIKIreporter.nih.gov
Alzheimer's Disease and Related Dementia-like Sequelae of SARS-CoV-2 Infection: Virus-Host Interactome, Neuropathobiology, and Drug RepurposingNIHNational Institute on Aging2023$2,394,473May 15, 2023April 30, 2026CHENG, FEIXIONGreporter.nih.gov
Epithelial stem/progenitor cells as repair agents in diffuse alveolar damageNIHNational Heart, Lung, and Blood Institute2021 to 2022$2,388,592September 21, 2016May 31, 2025CHAPMAN, HAROLD Areporter.nih.gov
Development of a Microphysiological Organ-on-Chip System to Model AmyotrophicNIHNational Institute of Neurological Disorders and Stroke2021 to 2022$2,385,538September 15, 2017February 28, 2024SVENDSEN, CLIVE NIELSreporter.nih.gov
Regulation of Ribosome Biogenesis in Hematopoietic Stem CellsNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2024$2,385,337September 18, 2020August 31, 2025TONG, WEIreporter.nih.gov
CRISPR-induced cardiovascular progenitor cells to repair myocardial infarctionNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,382,655April 1, 2021March 31, 2026WANG, YIGANGreporter.nih.gov
Multi-organ-on-chip device for modeling opioid reinforcement and withdrawal, and the negative affective component of pain: a therapeutic screening tool.NIHNational Center for Advancing Translational Sciences2022 to 2024$2,380,820September 26, 2019July 31, 2025MAIDMENT, NIGEL Treporter.nih.gov
The 4D nucleome of muscle regeneration in ischemia-induced tissue damage and repairNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,377,116September 20, 2020August 31, 2025DIAO, YARUIreporter.nih.gov
Engineering Clinical Trials on a Chip for Dystrophin-Deficient Muscular DystrophyNIHNational Center for Advancing Translational Sciences2022 to 2024$2,376,851September 1, 2020July 31, 2026KIM, DEOK-HOreporter.nih.gov
Discovering Wdfy3 as a novel regulator of macrophage efferocytosis by genome-wide CRISPR screenNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,375,761May 1, 2020April 30, 2026ZHANG, HANRUIreporter.nih.gov
Genome Wide Association Study for Childhood ObesityNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2021 to 2024$2,372,606July 15, 2008June 30, 2026GRANT, STRUAN F Areporter.nih.gov
Improve Lung Regeneration Through Targeting Tuft Cells Following Viral InfectionNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,371,262August 20, 2021June 30, 2026QUE, JIANWENreporter.nih.gov
Developing Human Pluripotent Stem Cell Tools for Region-Specific Pain CircuitsNIHNational Institute of Neurological Disorders and Stroke2024$2,370,000September 6, 2024August 31, 2027IYER, NISHAreporter.nih.gov
Validation of an in vitro model of progressive fibrosis that mimics Idiopathic Pulmonary FibrosisNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,367,083February 15, 2021January 31, 2026GOMPERTS, BRIGITTE Nreporter.nih.gov
Uncovering molecular effectors of mammalian agingNIHNational Institute on Aging2021 to 2022$2,366,000September 30, 2018May 19, 2025WAGERS, AMY JOreporter.nih.gov
C9orf72 frontotemporal dementia (FTD) and amyotrophic lateral sclerosis(ALS): using patient cells and CRISPR to reveal therapeutic approachesNIHNational Institute on Aging2021 to 2022$2,365,559May 1, 2021April 30, 2024CONKLIN, BRUCE Rreporter.nih.gov
Synaptopathy and Pathogenesis in Frontotemporal Dementia: Role of CYLDNIHNational Institute on Aging2023$2,364,013June 1, 2023May 31, 2026YAO, WEI-DONGreporter.nih.gov
Regulation of HIV latency by microglial-neuronal interactionsNIHNational Institute on Drug Abuse2021 to 2023$2,363,459September 15, 2019July 31, 2025KARN, JONATHANreporter.nih.gov
Modeling the impact of regulatory and splicing variants on cellular function in Alzheimer's diseaseNIHNational Institute on Aging2021$2,360,820March 1, 2021February 29, 2024RAJ, TOWFIQUEreporter.nih.gov
Generation of four-chambered hearts through organoid fusionsNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,358,480September 1, 2024August 31, 2026LI, GUANGreporter.nih.gov
Integrated Microphysiological System of Cerebral Organoid and Blood Vessel for Disease Modeling and Neuropsychiatric Drug screeningNIHNational Center for Advancing Translational Sciences2021 to 2022$2,355,934February 15, 2018January 31, 2025LEONG, KAM Wreporter.nih.gov
Multipotent ABCB5-positive cell therapeutics for corneal diseaseNIHNational Eye Institute2021 to 2022$2,352,662April 1, 2018January 31, 2024FRANK, NATASHA Yreporter.nih.gov
Vsx2 Dependent Regulation of Retinal Progenitor Cell PropertiesNIHNational Eye Institute2021 to 2024$2,351,133August 1, 2003July 31, 2025LEVINE, EDWARD Mreporter.nih.gov
Progesterone Receptor (PR) Signaling Cross Talk Drives ER+ Breast CancerNIHNational Cancer Institute2021 to 2024$2,348,652February 13, 2020July 31, 2025LANGE, CAROL Areporter.nih.gov
Investigating the molecular mechanisms of HIV/AIDS associated neurological disorders using microglia and cerebral organoids derived from induced pluripotent stem cellsNIHNational Institute on Drug Abuse2021 to 2023$2,348,133September 1, 2019July 31, 2025RANA, TARIQ Mreporter.nih.gov
Dark GPCR signaling underlying the Microbiome-Gut-Brain Axis for Alzheimer's Disease and Related DementiaNIHNational Institute of Neurological Disorders and Stroke2023$2,344,291August 18, 2023July 31, 2026CHENG, FEIXIONGreporter.nih.gov
Molecular Aspects of Cytomegalovirus LatencyNIHNational Institute of Allergy and Infectious Diseases2021 to 2024$2,342,650December 1, 1984January 31, 2028HANCOCK, MEAGHAN Hreporter.nih.gov
Mesenchymal modulation of epithelial metaplasia in lung fibrosisNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,340,812February 1, 2021December 31, 2024PENG, TIENreporter.nih.gov
Targeting the genotype to phenotype link in HCM as a therapeutic strategyNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,339,175March 1, 2021February 28, 2026MERCOLA, MARKreporter.nih.gov
Developmental Origin, Injury and Epigenomic Regulation of NF1-Associated Peripheral Nerve Sheath TumorsNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$2,339,120April 15, 2021June 30, 2024ZHU, YUANreporter.nih.gov
Safety and Efficacy of Human Clinical Trials Using Kidney-on-a-Chip Microphysiological SystemsNIHNational Center for Advancing Translational Sciences2022 to 2024$2,334,876July 15, 2020June 30, 2026FREEDMAN, BENJAMIN SOLOMONreporter.nih.gov
2/7-Collaborative genomic studies of Tourette DisorderNIHNational Institute of Mental Health2021 to 2022$2,333,736July 27, 2018September 30, 2023STATE, MATTHEW W.reporter.nih.gov
Integrated Cellular and Tissue Engineering for Ischemic Heart DiseaseNIHNational Heart, Lung, and Blood Institute2021 to 2022$2,333,316September 15, 2016May 31, 2025ZHANG, JIANYIreporter.nih.gov
Determining the mechanism of IFIH1 disease-associated variants on beta-cell and immune responses in Type 1 diabetesNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2022$2,332,346September 15, 2020December 31, 2022TSE, HUBERT Mreporter.nih.gov
Modeling autoimmune pathogenesis and beta cell destruction by T1D immune systemsNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2023$2,328,420September 20, 2019May 31, 2024SYKES, MEGANreporter.nih.gov
Targeting Aging to prevent Alzheimer's Disease: the Geroscience ApproachNIHNational Institute on Aging2021 to 2024$2,327,496April 15, 2020September 30, 2025LITHGOW, GORDON Jreporter.nih.gov
Mechanisms whereby IFN-gamma sensitizes AML to the graft-vs-leukemia effectNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,325,780April 20, 2021March 31, 2026SHLOMCHIK, WARREN Dreporter.nih.gov
Nextgen AD Models, Endotypes, and ScreeningNIHNational Institute on Aging2024$2,319,456June 1, 2024May 31, 2027SUBRAMANIAM, SHANKARreporter.nih.gov
Novel roles for p27 as transcriptional co-regulator of cJun in stem cells and developmentNIHNational Cancer Institute2021 to 2024$2,319,039September 1, 2020August 31, 2025SLINGERLAND, JOYCE MARIEreporter.nih.gov
Novel Intervention Approaches to Alleviate Allogeneic Transplant-Related Morbidity and MortalityNIHNational Cancer Institute2021 to 2024$2,315,110September 3, 2018January 31, 2026SORROR, MOHAMEDreporter.nih.gov
Cell-type-specific NRXN1alpha alternative splicing changes in psychiatric diseaseNIHNational Institute of Mental Health2021 to 2023$2,314,430July 18, 2019April 30, 2025FANG, GANGreporter.nih.gov
Gut microbes modulate immune pathways in intestinal stem cells to influence their lineageNIHNational Institute of Allergy and Infectious Diseases2021 to 2024$2,311,160June 12, 2020May 31, 2026BUCHON, NICOLASreporter.nih.gov
A vascularized patient-derived iPSC liver acinus microphysiology system as an innovative precision medicine platform for optimizing clinical trial design for nonalcoholic fatty liver diseaseNIHNational Center for Advancing Translational Sciences2022 to 2024$2,306,928July 15, 2020June 30, 2026TAYLOR, D. LANSINGreporter.nih.gov
Transplantation of MHC Homozygous Vascular Progenitors in PrimatesNIHNational Heart, Lung, and Blood Institute2021 to 2022$2,302,970September 20, 2016May 31, 2025SLUKVIN, IGOR I.reporter.nih.gov
T cell invasion of the stem cell compartment during immune-mediated GI damageNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,299,846January 1, 2021December 31, 2025HANASH, ALAN Mreporter.nih.gov
A novel role for E2fs: E2f7 and E2f8 control motile ciliogenesisNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,299,186July 15, 2021June 30, 2026MOLL, UTE MARTHAreporter.nih.gov
Engineering optimization and scaling enables high quality pancreatic islet cryopreservation for banking and transplantNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2024$2,294,596September 22, 2021July 31, 2025FINGER, ERIK BRIANreporter.nih.gov
Cell Therapy for Neuroprotection in Congenital Heart DiseaseNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,294,475December 15, 2017April 30, 2027ISHIBASHI, NOBUYUKIreporter.nih.gov
Understanding and targeting bone marrow microenvironment in myelofibrosisNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,288,703January 1, 2021December 31, 2025DING, LEIreporter.nih.gov
Joint Pain on a Chip: Mechanistic Analysis Therapeutic Targets and an Empirical Strategy for Personalized Pain ManagementNIHNational Center for Advancing Translational Sciences2021$2,287,391September 26, 2019July 31, 2025GOLD, MICHAEL Sreporter.nih.gov
ApoE, lipid and immune mechanisms of human neurons and gliaNIHNational Institute on Aging2023$2,284,296December 15, 2022November 30, 2025ISACSON, OLEreporter.nih.gov
Sex-dependent role of 5HT1A receptors in adult neurogenesis and hippocampal functionNIHNational Institute of Mental Health2021 to 2024$2,284,076February 1, 2020November 30, 2025SONG, JUANreporter.nih.gov
Uncovering treatment targets for peripheral nerve sheath tumor progression in NF1NIHNational Institute of Neurological Disorders and Stroke2021 to 2024$2,281,119September 1, 2020June 30, 2025LARGAESPADA, DAVID ANDREWreporter.nih.gov
Artery biomechanics and vascular damage in sickle cell diseaseNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,274,529May 1, 2021April 30, 2026BOTCHWEY, EDWARD A.reporter.nih.gov
MicroRNA regulation of neural tube closureNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2021 to 2024$2,271,604March 10, 2020February 28, 2025PARCHEM, RONALD Jreporter.nih.gov
Transcriptional Regulation of Lung Alveolar RegenerationNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,270,370February 1, 2021December 31, 2024MORRISEY, EDWARD Ereporter.nih.gov
Transcriptomic Entropy to Quantify Maturation of PSC-Derived CardiomyocytesNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,267,763August 1, 2021July 31, 2025KWON, CHULANreporter.nih.gov
Role of the local vascular microenvironment in the bone marrow response to inflammationNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,264,190July 20, 2021December 31, 2024LUCAS, DANIELreporter.nih.gov
Understanding the role of stellate cells in the liver hematopoietic stem cell nicheNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,262,921August 1, 2020July 31, 2025DING, LEIreporter.nih.gov
Temporal program for cell fate specification in the mouse embryoNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2021 to 2024$2,262,020August 1, 2020July 31, 2025ZERNICKA-GOETZ, MAGDALENAreporter.nih.gov
Determining the Intrinsic and Environmental Signal Contributing to Early T1D ProgressionNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2023$2,260,661September 15, 2020June 30, 2025CHEN, SHUIBINGreporter.nih.gov
Fibroblast Growth Factor and Energy MetabolismNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2024$2,257,939July 3, 2015March 31, 2026TSENG, YU-HUAreporter.nih.gov
Mechanisms of oxysterol-induced oligodendrogenesisNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$2,255,433December 15, 2019November 30, 2024BENNER, ERIC Jreporter.nih.gov
Loss of TDP-43 disrupts the prefrontal neural activity and circuitry: relevance for TDP-43 linked ADRDNIHNational Institute of Neurological Disorders and Stroke2022$2,255,378September 19, 2022August 31, 2025LI, YUNreporter.nih.gov
Tympanic membrane progenitor cells in homeostasis in injuryNIHNational Institute on Deafness and Other Communication Disorders2021 to 2024$2,250,702April 25, 2020March 31, 2026TWARD, AARONreporter.nih.gov
Epigenetics of inner ear neurosensory cell developmentNIHNational Institute on Deafness and Other Communication Disorders2021 to 2024$2,250,638July 1, 2020June 30, 2025MARTIN, DONNA M.reporter.nih.gov
Functional Genomics of Tibetan AdaptationsNIHNational Heart, Lung, and Blood Institute2021 to 2023$2,246,453April 1, 2014June 30, 2025DI RIENZO, ANNAreporter.nih.gov
Development of ASH1L inhibitors for acute leukemiaNIHNational Cancer Institute2021 to 2024$2,243,021December 1, 2019November 30, 2025GREMBECKA, JOLANTAreporter.nih.gov
Blockade of IL-23 for the Prevention of Graft Versus Host DiseaseNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,237,924April 15, 2021March 31, 2026DROBYSKI, WILLIAM R.reporter.nih.gov
Functional Validation of TDP-43 splicing repression for frontotemporal degenerationNIHNational Institute of Neurological Disorders and Stroke2021 to 2022$2,237,856September 1, 2021August 31, 2023WONG, PHILIP Creporter.nih.gov
PCTC Administrative Coordinating CenterNIHNational Heart, Lung, and Blood Institute2021 to 2022$2,233,284September 20, 2016May 31, 2025TERRIN, MICHAEL Lreporter.nih.gov
Gene editing ELANE to understand and treat severe congenital neutropeniaNIHNational Heart, Lung, and Blood Institute2021 to 2023$2,233,070January 1, 2020December 31, 2024BAUER, DANIEL EVANreporter.nih.gov
Contribution of macrophages in the HSC nicheNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,230,269April 1, 2021February 28, 2026STEIDL, ULRICHreporter.nih.gov
Intraoperative bioprinting of composite tissues with zonal stratification for craniomaxillofacial reconstructionNIHNational Institute of Dental & Craniofacial Research2021 to 2024$2,227,502January 1, 2020December 31, 2025OZBOLAT, IBRAHIMreporter.nih.gov
The roles of regional specialization, mechanical forces and epigenetic memory after perturbation and injury of the intestinal stem cell microenvironmentNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2023$2,226,844September 5, 2014August 31, 2024KLEIN, OPHIR Dreporter.nih.gov
Stem Cells and AgingNIHNational Institute of General Medical Sciences2021$2,226,780July 1, 2017June 30, 2024QUESENBERRY, PETER J.reporter.nih.gov
Genetic Regulation of Nonalcoholic Fatty Liver DiseaseNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2024$2,221,739June 8, 2021March 31, 2026MEDINA, MARISA WONGreporter.nih.gov
Multiplex base/prime editors for in vivo selection of modified HSPCs in hemoglobinopathyNIHNational Heart, Lung, and Blood Institute2022 to 2024$2,218,334January 17, 2017December 31, 2025KIEM, HANS-PETERreporter.nih.gov
Modulation of Tumor Microenvironment for Improved Therapy of Pancreatic CancerNIHNational Cancer Institute2021 to 2024$2,211,941December 20, 2019May 31, 2025JAIN, MANEESHreporter.nih.gov
Development of a Synthetic, Cell-Permeable Peptide for the Inhibition of CDK5-p25 Hyperactivity in Amyotrophic Lateral SclerosisNIHNational Institute of Neurological Disorders and Stroke2021 to 2022$2,210,678September 22, 2021August 31, 2024WERNER, JOHN KENTreporter.nih.gov
Development of Brain Organoids to Study the Impact of HIV-1, Drugs of Abuse and Aging on Cognitive ImpairmentNIHNational Institute on Drug Abuse2021 to 2024$2,208,551July 15, 2020May 2, 2024NIXON, DOUGLAS Freporter.nih.gov
Cell autonomous and non-cell autonomous phenotypes due to genetic risk for late onset Alzheimers diseaseNIHNational Institute on Aging2021$2,207,391May 1, 2021April 30, 2024POON, WAYNE Wreporter.nih.gov
Developmental Heterogeneity of Pulmonary Endothelial Phenotype at Single Cell ResolutionNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,206,652September 15, 2021December 1, 2024ALVIRA, CRISTINA MARIAreporter.nih.gov
AML mutation-guided drugging of DNA repairNIHNational Cancer Institute2021 to 2024$2,200,960March 1, 2020January 31, 2026SKORSKI, TOMASZreporter.nih.gov
Mechanism of action of PTH: New signaling components that regulate bone formation and bone marrow fatNIHNational Institute of Arthritis and Musculoskeletal and Skin Diseases2021 to 2024$2,199,383May 5, 2020March 31, 2026BARON, ROLAND Ereporter.nih.gov
Biology of Submucosal Gland Stem Cells in the AirwayNIHNational Heart, Lung, and Blood Institute2022 to 2024$2,198,254June 20, 2022May 31, 2025ENGELHARDT, JOHN Freporter.nih.gov
A microphysiologic multicellular organ-on-chip to inform clinical trials in FTD/ALSNIHNational Center for Advancing Translational Sciences2022 to 2024$2,198,065July 1, 2020November 30, 2025SVENDSEN, CLIVE NIELSreporter.nih.gov
Mechanisms of Silencing of Retroviral DNAs in Embryonic Cell LinesNIHNational Cancer Institute2021 to 2024$2,196,107August 1, 1981December 31, 2024GOFF, STEPHEN PAINEreporter.nih.gov
Mechanisms of epithelial repair and remodeling in pulmonary fibrosisNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,193,295July 15, 2020June 30, 2025KROPSKI, JONATHAN ANDREWreporter.nih.gov
A Novel Role for NFATC1 in Modulating Cardiac ExcitabilityNIHNational Heart, Lung, and Blood Institute2021 to 2023$2,192,974July 1, 2020June 30, 2025TRISTANI-FIROUZI, MARTINreporter.nih.gov
Alternative RNA splicing events contribute to the onset of islet dysfunction in T1DNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2023$2,191,256September 15, 2020June 30, 2024SUSSEL, LORIreporter.nih.gov
Molecular Segregation of Parkinson’s Disease by Patient-Derived NeuronsNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$2,183,720June 1, 2020May 31, 2026FENG, JIANreporter.nih.gov
Genetic mechanisms of type 1 diabetes risk in stress-induced pancreatic isletsNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2022$2,181,407August 1, 2019May 31, 2023GAULTON, KYLE JEFFRIEreporter.nih.gov
Mechanisms of gene regulation and RNA processing in synucleinopathiesNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$2,181,405July 1, 2020June 30, 2025MAZZULLI, JOSEPH Rreporter.nih.gov
Novel patient-derived 3D platform for detecting TDP-43 proteinopathy and associated biomarkers for ALS/FTDNIHNational Institute of Neurological Disorders and Stroke2022 to 2023$2,175,360February 15, 2022January 31, 2025GHAFFARI, LAYLAreporter.nih.gov
Resilience to Alzheimer's disease by targeting adult hippocampal neurogenesisNIHNational Institute on Aging2024$2,173,794September 1, 2024August 31, 2027CHOI, SE HOONreporter.nih.gov
Targeting an RNA Binding Protein Network in Acute Myeloid LeukemiaNIHNational Cancer Institute2021 to 2024$2,173,391June 1, 2020May 31, 2025ABDEL-WAHAB, OMARreporter.nih.gov
A microphysiological system of tendon inflammation and fibrosis for drug screening and efficacy testingNIHNational Center for Advancing Translational Sciences2022 to 2024$2,172,600August 15, 2020July 31, 2025AWAD, HANI Areporter.nih.gov
Muscle progenitor cell-based implants for dynamic laryngeal muscle reconstructionNIHNational Institute on Deafness and Other Communication Disorders2021 to 2024$2,172,460July 15, 2015June 30, 2025HALUM, STACEY L.reporter.nih.gov
miR-223 regulates endothelial to hematopoietic transitionNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2023$2,165,334April 15, 2020January 31, 2025NICOLI, STEFANIAreporter.nih.gov
Sox Proteins Modulate Genomic Specificity of B-catenin Regulated Transcription in the Developing GutNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2024$2,163,911January 15, 2021December 31, 2025ZORN, AARON Mreporter.nih.gov
The µSiM-hNVU - a human BBB platform for the study of brain injury mechanisms during systemic infectionNIHNational Heart, Lung, and Blood Institute2022 to 2024$2,162,325September 3, 2020August 31, 2025MCGRATH, JAMES Lreporter.nih.gov
Biological Comparisons Among Three Derivative Models of Glioma Patient Cancers Under Microenvironmental StressNIHNational Cancer Institute2021 to 2022$2,160,078September 17, 2018August 31, 2024WILLEY, CHRISTOPHER Dreporter.nih.gov
Cellular Epigenetic Heterogeneity as a Predeterminant of Malignant Transformation PotentialNIHNational Cancer Institute2021 to 2023$2,160,040December 3, 2018November 30, 2024LAIRD, PETER Wreporter.nih.gov
Non-coding RNA regulation of early neural developmentNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$2,159,490December 1, 2019November 30, 2025NISWANDER, LEE A.reporter.nih.gov
Therapeutic Targeting of Casein Kinase-1-delta in Primary and Metastatic Breast CancerNIHNational Cancer Institute2021 to 2023$2,159,273June 4, 2018November 30, 2023DUCKETT, DEREK RONALDreporter.nih.gov
Neurotoxicity of particulate matter and its interaction with APOE in neurodegenerationNIHNational Institute of Neurological Disorders and Stroke2022$2,159,148September 20, 2022August 31, 2025KITAZAWA, MASASHIreporter.nih.gov
The Role of PHF6 in HSC self-renewal and myeloid expansionNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,150,399January 6, 2021December 31, 2025PARALKAR, VIKRAM R.reporter.nih.gov
Role of SCN1B in Inherited EpilepsyNIHNational Institute of Neurological Disorders and Stroke2021 to 2023$2,149,827February 1, 2011January 31, 2025ISOM, LORI L.reporter.nih.gov
Immunogenicity of Human Stem Cell-Derived Beta Cells and Muscle Cells in Humanized MiceNIHOffice of the Director, National Institutes of Health2021 to 2022$2,147,498August 15, 2019July 31, 2024GREINER, DALE LESLIEreporter.nih.gov
The regulation of thrombopoietin levelsNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,146,386August 1, 2021April 30, 2025KHORIATY, RAMIreporter.nih.gov
Targeting plasma membrane spatial dynamics to suppress aberrant Wnt signalingNIHNational Cancer Institute2021 to 2024$2,143,591September 3, 2020May 31, 2026CHAPKIN, ROBERT STEPHENreporter.nih.gov
Readily Available Stem Cell-Based Vascular Grafts for Emergent Surgical CareNIHNational Heart, Lung, and Blood Institute2021 to 2023$2,141,117July 1, 2020June 30, 2025QYANG, YIBINGreporter.nih.gov
Improvement of Animal Models for TMJ Stem Cell-Based RegenerationNIHNational Institute of Dental & Craniofacial Research2021 to 2023$2,135,816July 15, 2019April 30, 2025EMBREE, MILDRED CHRISTINEreporter.nih.gov
Methylglyoxal drives astrocyte senescence to mediate neurodegeneration in Alzheimer's diseaseNIHNational Institute on Aging2021 to 2024$2,135,509August 1, 2020July 31, 2025KAPAHI, PANKAJreporter.nih.gov
Toward Understanding the Role of the Polycomb Complex in Skin ControlNIHNational Institute of Arthritis and Musculoskeletal and Skin Diseases2021 to 2024$2,130,652February 1, 2016August 31, 2025EZHKOVA, ELENAreporter.nih.gov
Manganese exposure susceptibility as a modifier of excitotoxicity in Alzheimer's DiseaseNIHNational Institute of Environmental Health Sciences2021 to 2024$2,124,884February 1, 2020October 31, 2025HARRISON, FIONA EDITHreporter.nih.gov
Improving hepatocellular carcinoma mouse modeling by understanding the malignant potential and biology of liver cell subpopulationsNIHNational Cancer Institute2021 to 2024$2,123,250June 1, 2020May 31, 2025ZHU, HAOreporter.nih.gov
Human CDX2 Cells and Cardiac RepairNIHNational Heart, Lung, and Blood Institute2021 to 2023$2,116,925July 21, 2020May 31, 2025CHAUDHRY, HINA Wreporter.nih.gov
Development of CRISPR/Cas9-based exon-skipping strategies for the treatment of USH-associated deafnessNIHNational Institute on Deafness and Other Communication Disorders2022 to 2024$2,113,099August 22, 2022June 30, 2027LIU, XUE Zreporter.nih.gov
Defining post-transcriptional regulons in intestinal epithelial regenerationNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2024$2,109,090April 1, 2020March 31, 2026HAMILTON, KATHRYN ELIZABETHreporter.nih.gov
UCSD Biomedical Scientist Career Development Program in GlycoscienceNIHNational Heart, Lung, and Blood Institute2021 to 2022$2,105,436July 1, 2018June 30, 2024ESKO, JEFFREY Dreporter.nih.gov
Altered Hippocampal Neurogenesis and Cognition via Maneb-mediated Changes in the Thiol Redox Proteome.NIHNational Institute of Environmental Health Sciences2021 to 2023$2,104,664March 1, 2017February 28, 2026ROEDE, JAMES Rreporter.nih.gov
Modeling Alzheimer's disease genetic variants in hiPSCNIHNational Institute on Aging2021 to 2023$2,102,361May 1, 2019February 28, 2025DUAN, JUBAOreporter.nih.gov
Genetic Regulation of Inner, Middle and Outer Ear DevelopmentNIHNational Institute on Deafness and Other Communication Disorders2021 to 2024$2,101,738March 22, 2013November 30, 2025GROVES, ANDREW Kreporter.nih.gov
Cardiac Mechanisms of Sudden Unexpected Death in EpilepsyNIHNational Heart, Lung, and Blood Institute2021 to 2023$2,101,543July 1, 2020June 30, 2025ISOM, LORI L.reporter.nih.gov
Targeting Dyrk1a to Promote Donor-independent Platelet ProductionNIHNational Heart, Lung, and Blood Institute2021 to 2023$2,097,567February 20, 2020January 31, 2025GOLDFARB, ADAM N.reporter.nih.gov
Targeting cancer stem cells in JAK2V617F induced neoplasmNIHNational Cancer Institute2021 to 2024$2,096,959February 15, 2020January 31, 2025LI, SHAOGUANGreporter.nih.gov
Notch/Robo Regulated Mechanisms Governing Cell Fate AcquisitionNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2021 to 2024$2,096,618April 1, 2020December 31, 2025HINCK, LINDSAY Ereporter.nih.gov
Mini-Livers Derived from Human IPS Cells for Modeling Steatosis and TherapyNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2024$2,096,374August 1, 2014May 31, 2025SOTO-GUTIERREZ, ALEJANDROreporter.nih.gov
Mechanisms and Regulation of Brain Iron UptakeNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$2,095,116December 1, 2019November 30, 2025CONNOR, JAMES ROBERTreporter.nih.gov
The role of Myt1l in the developing and adult mouse brainNIHNational Institute of Mental Health2021 to 2023$2,094,570April 1, 2019January 31, 2024WERNIG, MARIUSreporter.nih.gov
Cell Type and Regional Vulnerability in Frontotemporal DementiaNIHNational Institute of Neurological Disorders and Stroke2021$2,094,351August 1, 2021July 31, 2024TEMPLE, SALLYreporter.nih.gov
Deciphering Trophic Signaling Programs Governing Peripheral Sensory Nervous System DevelopmentNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$2,093,638December 1, 2019November 30, 2025ZUNDER, ELIreporter.nih.gov
Extending the temporal and spatial capabilities of single-molecule methodsNIHNational Institute of General Medical Sciences2021 to 2024$2,093,498September 1, 2021August 31, 2025CHU, STEVENreporter.nih.gov
Understanding Frontotemporal Dementia Using Drosophila and iPSC ModelsNIHNational Institute of Neurological Disorders and Stroke2022$2,086,468April 15, 2017March 31, 2025GAO, FEN-BIAOreporter.nih.gov
Modeling CNS dynamics in HIV infection and cannabinoids with forebrain organoidsNIHNational Institute on Drug Abuse2021 to 2023$2,085,642August 1, 2019June 30, 2025JORDAN-SCIUTTO, KELLY Lreporter.nih.gov
Resolving the Role of Neuronal STING in Amyotrophic Lateral Sclerosis and Frontotemporal DementiaNIHNational Institute of Neurological Disorders and Stroke2023$2,085,362January 5, 2023December 31, 2025WAINGER, BRIAN JASONreporter.nih.gov
Ex vivo analysis of human brain tumor cells in a microvascular niche modelNIHNational Cancer Institute2021 to 2024$2,082,785February 4, 2020January 31, 2025FAN, RONGreporter.nih.gov
Targeting the Circadian Rhythm in Glioblastoma Stem Cells (R01CA238662)NIHNational Cancer Institute2021 to 2024$2,081,567July 1, 2021November 30, 2024RICH, JEREMY Nreporter.nih.gov
Function of RUNX1 in diverse Down syndrome tissuesNIHNational Heart, Lung, and Blood Institute2021 to 2023$2,081,565September 1, 2023August 31, 2024ALLEN, MARY Areporter.nih.gov
Mechanisms of Regulation of the m6A mRNA Methylation MachineryNIHNational Institute of General Medical Sciences2021 to 2024$2,080,305August 14, 2020June 30, 2025ALARCON, CLAUDIO Rreporter.nih.gov
Interplay between AMPK and Hippo Signaling Regulates Ocular Antiviral Response to Zika virus infectionNIHNational Eye Institute2021 to 2024$2,079,783January 1, 2021December 31, 2025ARUMUGASWAMI, VAITHILINGARAJAreporter.nih.gov
The cis-regulatory grammar and epigenetic control of human interneuron progenitor specificationNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$2,079,315June 15, 2021May 31, 2026KROLL, KRISTEN Lreporter.nih.gov
Hematopoiesis in germline RUNX1mutation carriers: impact of inflammation and the bone marrow nicheNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,073,245July 1, 2021May 31, 2026AGARWAL, ANUPRIYAreporter.nih.gov
Cellular Reservoirs of HIVNIHNational Institute of Allergy and Infectious Diseases2021 to 2023$2,070,157September 23, 2019August 31, 2025COLLINS, KATHLEEN L.reporter.nih.gov
Mechanisms regulating functional heterogeneity of subcutaneous adipose tissues in womenNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2023$2,068,261July 8, 2019April 30, 2025FRIED, SUSAN Kreporter.nih.gov
Oligodendrocyte Progenitors and Mechanisms of Human Vascular White Matter InjuryNIHNational Institute of Neurological Disorders and Stroke2021 to 2023$2,066,705July 15, 2019April 30, 2026BACK, STEPHEN ARTHURreporter.nih.gov
Connecting 3D genome misfolding to transcriptional silencing in fragile X syndromeNIHNational Institute of Mental Health2021 to 2024$2,066,257August 15, 2019January 31, 2029PHILLIPS-CREMINS, JENNIFER ELIZABETHreporter.nih.gov
Neuronal ABCA7 loss of function and Alzheimer’s diseaseNIHNational Institute on Aging2023$2,063,098June 1, 2023May 31, 2026KANEKIYO, TAKAHISAreporter.nih.gov
Mechanistic Understanding for the Role of Lin28b in Pancreatic Cancer ProgressionNIHNational Cancer Institute2021 to 2023$2,060,694February 19, 2019January 31, 2024MOSTOSLAVSKY, RAULreporter.nih.gov
Neural Circuit Control of Postnatal Quiescent Neural Stem Cell ActivationNIHNational Institute of Mental Health2021 to 2024$2,054,748November 19, 2014April 30, 2025YIN, HENRYreporter.nih.gov
The Role of PRDM16 in Cardiac Development and CardiomyopathyNIHNational Heart, Lung, and Blood Institute2021 to 2023$2,054,619July 15, 2020May 31, 2025BOUDINA, SIHEMreporter.nih.gov
Balancing Airway Progenitor versus Progeny: a Pathway from MitochondriaNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,054,106August 20, 2021June 30, 2026SUN, XINreporter.nih.gov
Bone marrow-targeted extracellular vesicles as a novel non-viral gene editor delivery platformNIHNational Center for Advancing Translational Sciences2022 to 2023$2,051,588July 1, 2022May 31, 2025THON, JONATHAN Nreporter.nih.gov
Treating Kidney Injury by Modulating Heat Shock Proteins Using Soundwaves Combined with Mesenchymal Stem Cells and Their Extracellular VesiclesNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2024$2,048,853August 30, 2021July 31, 2025THAKOR, AVNESH SINHreporter.nih.gov
Cancer patient on a chipNIHNational Cancer Institute2021 to 2024$2,041,238July 15, 2020June 30, 2025VUNJAK-NOVAKOVIC, GORDANAreporter.nih.gov
Neuronal quality control and neuroprotection in tauopathiesNIHNational Institute on Aging2021 to 2024$2,040,301August 1, 2007April 30, 2026CHU, CHARLEEN Treporter.nih.gov
Spatial Control of Myeloid DifferentiationNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,038,767August 15, 2021December 31, 2024LUCAS, DANIELreporter.nih.gov
Investigating a master regulator of large intestine stem cellsNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2024$2,038,576August 1, 2021July 31, 2025RAFII, SHAHINreporter.nih.gov
Aortic Valve Disease: Mechanisms and Therapeutic ApproachesNIHNational Heart, Lung, and Blood Institute2021 to 2023$2,037,372February 10, 2020January 31, 2025SRIVASTAVA, DEEPAKreporter.nih.gov
Characterization of progenitor populations in adult taste epitheliumNIHNational Institute on Deafness and Other Communication Disorders2021 to 2024$2,037,331July 1, 2020June 30, 2026BARLOW, LINDA Areporter.nih.gov
Structure function relationships from deep mutational scanning in human cardiomyopathyNIHNational Heart, Lung, and Blood Institute2021 to 2023$2,035,543January 1, 2020December 31, 2024ASHLEY, EUAN Areporter.nih.gov
Investigating epigenetic mechanisms in Down syndrome using human cellular modelsNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2023$2,034,753April 5, 2023March 31, 2026BARRETT, LINDY ELISEreporter.nih.gov
Pro-Inflammatory Stem Cell Variants in Cystic FibrosisNIHNational Heart, Lung, and Blood Institute2022 to 2024$2,034,476February 1, 2022January 31, 2026MCKEON, FRANK D.reporter.nih.gov
Predictive assessment of acute and chronic cardiotoxicity using combinatorially matured hPSC-CMsNIHNational Heart, Lung, and Blood Institute2021 to 2023$2,034,388December 1, 2022August 31, 2024GEISSE, NICHOLAS ANDREWreporter.nih.gov
Embryonic vascular stem-progenitors for treatment of ischemic retinopathiesNIHNational Eye Institute2021 to 2024$2,033,849February 1, 2021January 31, 2026ZAMBIDIS, ELIAS T.reporter.nih.gov
A novel epigenetic mechanism in early embryogenesisNIHNational Institute of General Medical Sciences2021 to 2024$2,033,719April 1, 2020March 31, 2026XIAO, ZHUO ANDREWreporter.nih.gov
A first in class, mechanism-guided, cell-based therapy for complex regional pain syndromeNIHNational Institute of Neurological Disorders and Stroke2022$2,033,135September 24, 2022August 31, 2025CHENG, JIANGUOreporter.nih.gov
Novel mechanisms of vasculogenesisNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,033,101June 5, 2021May 31, 2026SUMANAS, SAULIUSreporter.nih.gov
Neurobehavioral, cognitive, and mechanistic effects of intranasally administered neural stem cells and environmental enrichment after cortical impact injury in ratsNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$2,032,869September 1, 2021August 31, 2025KLINE, ANTHONY E.reporter.nih.gov
Dissecting the role of tau glycosylation in Alzheimer's diseaseNIHNational Institute on Aging2023$2,031,054April 15, 2023March 31, 2026WALCZAK, MACIEJreporter.nih.gov
Functional implications of CPVT1-associated RyR2 mutations in human cardiomyocytesNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,028,489September 1, 2021July 31, 2026MORAD, MARTINreporter.nih.gov
Functional analysis of mammalian midbody RNA in post-mitotic signaling functionsNIHNational Institute of General Medical Sciences2021 to 2024$2,023,221September 16, 2021August 31, 2025SKOP, AHNA RENEEreporter.nih.gov
Synthetic Mesenchymal Stem Cell Niches for Vascular TherapyNIHNational Heart, Lung, and Blood Institute2021 to 2023$2,023,009August 15, 2013July 31, 2025TAN, WEIreporter.nih.gov
Novel mechanism of intestinal stem cell agingNIHNational Institute on Aging2021 to 2024$2,022,936September 15, 2020May 31, 2025ZHENG, YIreporter.nih.gov
A stress-induced promoter pause release program in cardiomyocytes protecting against myocardial infarctionNIHNational Heart, Lung, and Blood Institute2021 to 2023$2,021,907December 15, 2019November 30, 2024ROSENFELD, MICHAEL Greporter.nih.gov
Genetic Analysis of MicroRNA Functions in Skin Stem Cells In VivoNIHNational Institute of Arthritis and Musculoskeletal and Skin Diseases2021 to 2024$2,013,300July 1, 2014November 30, 2025YI, RUIreporter.nih.gov
Targeted Small Molecule Inhibitors for Inv(16) LeukemiaNIHNational Cancer Institute2021 to 2023$2,012,862December 1, 2018November 30, 2024BUSHWELLER, JOHN HACKETTreporter.nih.gov
iPSC-derived Neurovascular OrganoidsNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$2,012,834April 15, 2020March 31, 2026LIPPMANN, ETHANreporter.nih.gov
Signaling Pathways that Regulate Scaling and Regeneration of the CerebellumNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$2,010,981February 1, 2015January 31, 2026JOYNER, ALEXANDRA L.reporter.nih.gov
Chromatin Organization Regulates OsteogenesisNIHNational Institute of Dental & Craniofacial Research2021 to 2024$2,010,351January 6, 2020December 31, 2024STEIN, GARY S.reporter.nih.gov
Genome Editing of Human iPSCs to Study Inherited Hypertrophic CardiomyopathyNIHNational Heart, Lung, and Blood Institute2021 to 2022$2,008,113March 10, 2015June 30, 2024WU, JOSEPH C.reporter.nih.gov
Exosome educated monocytes for acute radiation syndromeNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,007,828August 1, 2021July 31, 2025CAPITINI, CHRISTIANreporter.nih.gov
Skeletal FGF23 production mediated by GPCR/Gq/PKC signalingNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2024$2,006,965April 1, 2020March 31, 2026BASTEPE, MURATreporter.nih.gov
The role of APP in neurogenesis and AD in Down syndromeNIHNational Institute on Aging2022$2,005,131September 15, 2022August 31, 2025LAZAROV, ORLYreporter.nih.gov
Systems analysis of aggressive prostate cancer pathologyNIHNational Cancer Institute2021 to 2023$2,003,318September 1, 2019August 31, 2025COSTELLO, JAMES CHRISTOPHERreporter.nih.gov
Rab GTPases-mediated mitochondrial clearance in diabetic cardiomyopathyNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,003,229April 1, 2020March 31, 2026ONG, SANG GINGreporter.nih.gov
A Catalog of Cell Types and Genomic Elements in Tissues, Organoids and DiseaseNIHNational Human Genome Research Institute2021$2,002,687February 1, 2017January 31, 2022BERNSTEIN, BRADLEY EVANreporter.nih.gov
Matching panels of in vivo and in vitro model system of pediatric brain tumorsNIHNational Cancer Institute2021 to 2024$2,001,657March 3, 2020February 28, 2026LI, XIAONANreporter.nih.gov
TOPIC 414 : SYNTHETIC BIOLOGY GENE CIRCUITS FOR CANCER THERAPYNIHNational Cancer Institute2021$1,999,993August 1, 2021July 31, 2023LEE, GARYreporter.nih.gov
Anti-oxidant and Metabolic Phenotype in Regulating Tumor Specific T cell Memory ResponseNIHNational Cancer Institute2021 to 2024$1,999,491December 1, 2019November 30, 2025MEHROTRA, SHIKHARreporter.nih.gov
Phase 1/2a Clinical Study of Descartes-30 in Acute Respiratory Distress SyndromeNIHNational Heart, Lung, and Blood Institute2021 to 2022$1,998,233May 1, 2021April 30, 2024STEWART, CHARLES ANDREWreporter.nih.gov
Ontogeny and Function of Tumor-Resident Innate Lymphocytes and Innate-Like T CellsNIHNational Cancer Institute2021 to 2024$1,998,178September 1, 2020May 31, 2025LI, MINGreporter.nih.gov
Cell adhesion-dependent mechanisms of beta cell growth and homeostasisNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2023$1,998,151April 1, 2020February 28, 2025CIRULLI, VINCENZINOreporter.nih.gov
Psychosis-related Physiological and Neuronal Phenotypes in 22q11 Deletion SyndromeNIHNational Institute of Mental Health2021 to 2023$1,997,858September 1, 2019September 30, 2024CUBELLS, JOSEPH F.reporter.nih.gov
Generation of human skin organoids from pluripotency (Admin Supplement)NIHNational Institute of Arthritis and Musculoskeletal and Skin Diseases2021 to 2023$1,996,696September 17, 2019August 31, 2025KOEHLER, KARL RUSSELLreporter.nih.gov
Vascular Remodeling in the Bone Marrow Leukemic Niche: A Therapeutic Target?NIHNational Cancer Institute2021 to 2024$1,996,349April 1, 2020March 31, 2026MARCUCCI, GUIDOreporter.nih.gov
Evolving High Potency AAV Vectors for Neuromuscular Genome EditingNIHNational Institute of Arthritis and Musculoskeletal and Skin Diseases2021 to 2022$1,992,277September 10, 2018July 31, 2024ASOKAN, ARAVINDreporter.nih.gov
In Vivo Proof of Concept and Target Identification Using Small Molecule Stimulators of Brown AdipogenesisNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2022$1,988,528July 1, 2020July 31, 2024BOSS, OLIVIERreporter.nih.gov
Function of the Stem Cell Transcription Factor SOX2 in Prostatic EnlargementNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2024$1,988,247March 10, 2020December 31, 2025VANDER GRIEND, DONALD JAMESreporter.nih.gov
Genetic regulation of cardiac inflow tract formation in zebrafishNIHNational Heart, Lung, and Blood Institute2021 to 2024$1,982,777May 14, 2021April 30, 2025YELON, DEBORAHreporter.nih.gov
Role of Siglec-1 in HIV Interactions with Microglia and AstrocytesNIHNational Institute on Drug Abuse2021 to 2024$1,981,204July 15, 2020April 30, 2026SPEARMAN, PAUL W.reporter.nih.gov
InflammaGut: a drug-screenable co-culture system using gut-associated lymphocytes and autologous primary human gut epithelium that reports inflammationNIHNational Center for Advancing Translational Sciences2022 to 2023$1,980,716May 1, 2022January 31, 2025THELIN, BILLreporter.nih.gov
AF9(MLLT3) Function in Leukemia and Normal HematopoiesisNIHNational Cancer Institute2021 to 2023$1,980,668July 1, 2019June 30, 2025BUSHWELLER, JOHN HACKETTreporter.nih.gov
Modeling the Glioblastoma Microenvironment to Uncover Progression Mechanisms and Therapeutic TargetsNIHNational Cancer Institute2021 to 2024$1,980,275May 1, 2020April 30, 2026BRAT, DANIEL Jreporter.nih.gov
Human Microphysiological Model of Afferent Nociceptive SignalingNIHNational Center for Advancing Translational Sciences2021$1,978,863September 26, 2019January 31, 2025MOORE, MICHAEL Jreporter.nih.gov
Delirium in Children Undergoing Hematopoietic Stem Cell TransplantsNIHNational Cancer Institute2021 to 2024$1,975,976September 1, 2020May 31, 2026TRAUBE, CHANIreporter.nih.gov
Gastrin Regulation of Gastric Antral Stem and Corpus Progenitor CellsNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2024$1,975,882September 23, 2021August 31, 2025WANG, TIMOTHY CRAGINreporter.nih.gov
A renewable and genetically tractable human stem cell-derived multicellular platform for the study of fibrotic liver diseasesNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2024$1,974,527March 1, 2021February 28, 2025RICE, CHARLES Mreporter.nih.gov
Combined bioprinting with stem cell technology to regenerate skin burn woundsNIHNational Institute of General Medical Sciences2021 to 2024$1,972,718August 1, 2021May 31, 2026SQUARIZE, CRISTIANEreporter.nih.gov
Interplay between PDGFRA, oxygen-regulated translation and KSHV in Kaposi's sarcomagenesisNIHNational Cancer Institute2021 to 2024$1,972,648May 1, 2010February 28, 2026SHEMBADE, NOULA DATTUreporter.nih.gov
Engineered Neuroprotective Stem-Cell Exosomes for In Utero Spina Bifida TherapyNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$1,972,069September 30, 2020August 31, 2025FARMER, DIANA LEEreporter.nih.gov
Role of novel onco-histone mutations in B-cell malignanciesNIHNational Cancer Institute2021 to 2023$1,967,972August 1, 2019July 31, 2025CESARMAN, ETHELreporter.nih.gov
UBE3A gain-of-function and parent-of-origin influence on neurodevelopmental phenotypesNIHNational Institute of Mental Health2021 to 2023$1,967,890September 1, 2019June 30, 2025ZYLKA, MARK J.reporter.nih.gov
Molecular characterization of biliverdin IXbeta reductaseNIHNational Heart, Lung, and Blood Institute2021 to 2024$1,962,131July 1, 2021March 31, 2026BAHOU, WADIE Freporter.nih.gov
The role of ER associated degradation (ERAD) in hematopoietic stem cellsNIHNational Heart, Lung, and Blood Institute2021 to 2024$1,953,048July 3, 2020June 30, 2026LI, QINGreporter.nih.gov
Defining epithelial polarity cues that direct cell fateNIHNational Heart, Lung, and Blood Institute2021 to 2024$1,952,921August 15, 2014January 31, 2026VARELAS, XARALABOSreporter.nih.gov
Pluripotent Stem Cell Derived 3D Retinas for Studies of Early Onset Retinal DegenerationNIHNational Eye Institute2021 to 2024$1,950,685April 1, 2020March 31, 2026WAHLIN, KARL Jreporter.nih.gov
Tumor matrix remodeling in anti-myeloma immunity and immunotherapyNIHNational Cancer Institute2021 to 2024$1,950,659July 1, 2020December 31, 2024ASIMAKOPOULOS, FOTIOSreporter.nih.gov
New Ways of Targeting K-RasNIHNational Cancer Institute2021 to 2022$1,950,085April 1, 2016March 31, 2023MCCORMICK, FRANK PATRICKreporter.nih.gov
Discovery of small molecule regulators of atrial cardiomyocyte action potential duration to restore normal cardiac rhythm in atrial fibrillationNIHNational Heart, Lung, and Blood Institute2021 to 2024$1,950,000June 10, 2021August 31, 2025COLAS, ALEXANDRE ROMAINreporter.nih.gov
Comprehensive Mapping of Long-Range Chromatin Interactions in Humanand Mouse GenomesNIHNational Human Genome Research Institute2021$1,949,357February 1, 2017January 31, 2023LEE, CHARLESreporter.nih.gov
DOT1L, reconstitution of plasmacytoid dendritic cells and alloimmunityNIHNational Heart, Lung, and Blood Institute2022 to 2024$1,948,900November 23, 2021March 31, 2026ZHANG, YIreporter.nih.gov
Genomic Effects on Right Ventricular Function, Clinical Features and Outcomes in CHDNIHNational Heart, Lung, and Blood Institute2021 to 2024$1,948,211September 30, 2009July 31, 2025NEWBURGER, JANE W.reporter.nih.gov
Define the effect of CLU SNP on the risk to Alzheimer's diseaseNIHNational Institute on Aging2022$1,942,962August 1, 2022July 31, 2025SHI, YANHONGreporter.nih.gov
Regulatory elements of replication timing and 3D genome organizationNIHNational Institute of General Medical Sciences2021 to 2024$1,941,046July 1, 2020June 30, 2025RIVERA-MULIA, JUAN CARLOSreporter.nih.gov
A Novel Approach to Molecular Cell Pathologies of Human Down Syndrome and DS-ADNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2021 to 2023$1,938,999September 12, 2017March 31, 2026LAWRENCE, JEANNE BENTLEYreporter.nih.gov
Investigating the effects of aerobic and resistance training in vivo on skeletal muscle metabolism in vitro in primary human muscle cells (MoTrMyo)NIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2024$1,938,650August 1, 2019May 31, 2026SPARKS, LAUREN MARIEreporter.nih.gov
Development of a DCLK1 siRNA Nanoparticle as Targeted Therapy to Treat Pancreatic CancerNIHNational Cancer Institute2021 to 2022$1,935,472August 22, 2018July 31, 2024DE OLIVEIRA, ELISEU O.reporter.nih.gov
Endocannabinoid Signaling during Early PregnancyNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2021 to 2024$1,933,902July 1, 1990May 31, 2026DEY, SUDHANSU Kreporter.nih.gov
Maternal programming of the stem cell-basophil axis for asthmaNIHNational Institute of Allergy and Infectious Diseases2021 to 2024$1,932,227July 20, 2020June 30, 2025GORSKA, MAGDALENA MARIAreporter.nih.gov

Organizations

OrganizationPlaceNIH awardsNIH amountNSF awardsNSF amount
Columbia University Health SciencesNew York, NY106$117.2 million0$0
Stanford UniversityStanford, CA139$110.1 million0$0
University of California, San FranciscoSan Francisco, CA126$108.4 million0$0
University of California, San DiegoLa Jolla, CA100$101.8 million0$0
University of Michigan at Ann ArborAnn Arbor, MI112$86.9 million0$0
University of PennsylvaniaPhiladelphia, PA106$81.6 million0$0
Johns Hopkins UniversityBaltimore, MD114$75.3 million0$0
University of California Los AngelesLos Angeles, CA92$70.9 million0$0
University of Pittsburgh at PittsburghPittsburgh, PA66$68.8 million0$0
Massachusetts General HospitalBoston, MA72$66.6 million0$0
Washington UniversitySaint Louis, MO84$65.6 million0$0
Baylor College of MedicineHouston, TX55$65.3 million0$0
Icahn School of Medicine at Mount SinaiNew York, NY62$62.1 million0$0
University of WashingtonSeattle, WA69$59.1 million0$0
University of Colorado DenverAurora, CO59$55.6 million0$0
Cincinnati Childrens Hosp Med CTRCincinnati, OH58$54.4 million0$0
Boston Children's HospitalBoston, MA51$53.8 million0$0
Rutgers University New BrunswickNew Brunswick, NJ15$53.4 million0$0
Yale UniversityNew Haven, CT47$52 million0$0
Emory UniversityAtlanta, GA59$51.8 million0$0
Weill Medical Coll of Cornell UnivNew York, NY55$51.1 million0$0
University of Wisconsin-MadisonMadison, WI62$48 million0$0
Univ of Massachusetts Med SCH WorcesterWorcester, MA44$47.5 million0$0
Albert Einstein College of MedicineBronx, NY42$45.6 million0$0
Northwestern University at ChicagoChicago, IL58$44.9 million0$0
Duke UniversityDurham, NC62$44.5 million0$0
Univ of North Carolina Chapel HillChapel Hill, NC54$43.4 million0$0
Sloan-Kettering Inst Can ResearchNew York, NY37$37 million0$0
University of MinnesotaMinneapolis, MN48$35 million0$0
Case Western Reserve UniversityCleveland, OH35$35 million0$0
University of Alabama at BirminghamBirmingham, AL32$32.6 million0$0
New York University School of MedicineNew York, NY40$32.2 million0$0
University of California-IrvineIrvine, CA24$32.2 million0$0
University of Nebraska Medical CenterOmaha, NE15$31.8 million0$0
University of California at DavisDavis, CA33$31.4 million0$0
J. David Gladstone InstitutesSan Francisco, CA19$29.5 million0$0
Brigham and Women's HospitalBoston, MA33$29.2 million0$0
University of Illinois at ChicagoChicago, IL27$28.7 million0$0
University of TX MD Anderson Can CTRHouston, TX40$28.3 million0$0
Boston University Medical CampusBoston, MA40$28.1 million0$0
Fred Hutchinson Cancer CenterSeattle, WA24$28 million0$0
Ut Southwestern Medical CenterDallas, TX35$27.9 million0$0
Massachusetts Institute of TechnologyCambridge, MA28$27.7 million0$0
University of Southern CaliforniaLos Angeles, CA39$27.5 million0$0
Children's Hosp of PhiladelphiaPhiladelphia, PA27$27.4 million0$0
Indiana University IndianapolisIndianapolis, IN45$27.1 million0$0
Beckman Research Institute/city of HopeDuarte, CA19$25.8 million0$0
Cedars-Sinai Medical CenterLos Angeles, CA25$24.8 million0$0
University of ChicagoChicago, IL28$24.7 million0$0
Temple Univ of the CommonwealthPhiladelphia, PA21$24.7 million0$0
Harvard Medical SchoolBoston, MA34$24.3 million0$0
University of Miami School of MedicineCoral Gables, FL25$23.7 million0$0
University of IowaIowa City, IA30$23.5 million0$0
Medical College of WisconsinMilwaukee, WI26$23.3 million0$0
Ohio State UniversityColumbus, OH32$22.3 million0$0
Regents of the University of IdahoMoscow, ID1$21.9 million0$0
University of RochesterRochester, NY31$21.7 million0$0
University of VirginiaCharlottesville, VA26$21.4 million0$0
Cornell UniversityIthaca, NY20$21.3 million0$0
Harvard UniversityCambridge, MA25$20.2 million0$0
Sanford Burnham Prebys Medical Discovery InstituteLa Jolla, CA15$19.9 million0$0
Beth Israel Deaconess Medical CenterBoston, MA16$19.6 million0$0
Vanderbilt University Medical CenterNashville, TN18$19.2 million0$0
University of Kansas Medical CenterKansas City, KS7$19.2 million0$0
Augusta UniversityAugusta, GA12$19 million0$0
Cleveland Clinic Lerner Com-CwruCleveland, OH19$18.9 million0$0
California Institute of TechnologyPasadena, CA11$18.8 million0$0
University of UtahSalt Lake City, UT28$17.9 million0$0
University of California-BerkeleyBerkeley, CA16$17.6 million0$0
University of FloridaGainesville, FL24$17.6 million0$0
University of Connecticut SCH of Med/dntFarmington, CT27$17.4 million0$0
Jackson LaboratoryBar Harbor, ME17$17.4 million0$0
Children's Research InstituteWashington, DC12$16.6 million0$0
University of Maryland BaltimoreBaltimore, MD23$16.6 million0$0
ST. Jude Children's Research HospitalMemphis, TN30$16.1 million0$0
Oregon Health & Science UniversityPortland, OR26$15.6 million0$0
Dana-Farber Cancer InstBoston, MA23$15.1 million0$0
Medical University of South CarolinaCharleston, SC18$14.6 million0$0
Lurie Children's Hospital of ChicagoChicago, IL11$14.6 million0$0
Rockefeller UniversityNew York, NY18$14.1 million0$0
University of ArizonaTucson, AZ14$13.9 million0$0
Vanderbilt UniversityNashville, TN22$13.8 million0$0
North Carolina State UniversityRaleigh, NC21$13.8 million0$0
Clemson UniversityClemson, SC6$13.7 million0$0
University of CincinnatiCincinnati, OH19$13.2 million0$0
University of Missouri-ColumbiaColumbia, MO12$13.2 million0$0
University of Colorado at BoulderBoulder, CO14$13 million0$0
SUNY at Stony BrookStony Brook, NY20$12.8 million0$0
Broad Institute, Inc.Cambridge, MA11$12.6 million0$0
Versiti Blood Health, Inc.Milwaukee, WI9$11.8 million0$0
University of ConnecticutStorrs, CT13$11.4 million0$0
University of Texas HLTH Sci CTR HoustonHouston, TX15$11.3 million0$0
Scripps Research Institute, theLa Jolla, CA7$11.2 million0$0
SUNY at BuffaloAmherst, NY11$10.8 million0$0
Mayo Clinic JacksonvilleJacksonville, FL11$10.7 million0$0
University of Texas HLTH Science CenterSan Antonio, TX15$10.7 million0$0
Mclean HospitalBelmont, MA3$10.6 million0$0
Fred Hutchinson Cancer Research CenterSeattle, WA27$10.5 million0$0
Boise State UniversityBoise, ID4$10.4 million0$0
University of KentuckyLexington, KY14$10.3 million0$0

Funding by fiscal year

Fiscal yearNIH awardsNIH amountNSF awardsNSF amount
202519$45,340,3950$0
20241,283$549,955,1810$0
20232,125$871,986,7620$0
20222,794$1,134,426,5880$0
20213,279$1,398,819,5310$0

Open federal funding opportunities

From Grants.gov: notices that funded awards in this table, and open notices on the same agency and assistance listing.

Open opportunityNumberAgencyListingClosesAward ceilingWhy it matches
Change of Recipient Organization (Type 7 Parent Clinical Trial Optional)PA-24-254NIHJuly 12, 2027Not listedNotice number printed on 3 awards here
Functional Target Validation for Alzheimer's Disease-Related DementiasRFA-NS-26-034NIH93.853November 6, 2026Not listedSame assistance listing 93.853 as 579 awards here
Clinical Trials and Ancillary Studies Conducted within NIH-Funded Clinical Trial Research Networks (UG3/UH3 - Clinical Trial Required)PAR-27-007NIH93.853November 10, 2026Not listedSame assistance listing 93.853 as 579 awards here
Amyotrophic Lateral Sclerosis (ALS) Intermediate Patient Population Expanded Access (U01 Clinical Trial Required)RFA-NS-26-001NIH93.853November 10, 2026Not listedSame assistance listing 93.853 as 579 awards here
Genomic and Biologic Therapies for ADRD (U01 Clinical Trial Optional)RFA-NS-26-030NIH93.853November 10, 2026Not listedSame assistance listing 93.853 as 579 awards here
Ethical, Legal and Social Implications (ELSI) Exploratory/Developmental Research Grant (R21 Clinical Trial Optional)PAR-25-369NIH93.853November 18, 2026Not listedSame assistance listing 93.853 as 579 awards here
Ethical, Legal and Social Implications (ELSI) Research (R01 Clinical Trial Optional)PAR-25-371NIH93.853November 18, 2026Not listedSame assistance listing 93.853 as 579 awards here
NIH StrokeNet Clinical Trials and Biomarker Studies for Stroke Treatment, Recovery, and Prevention (UG3/UH3 Clinical Trial Optional)PAR-25-052NIH93.853November 19, 2026Not listedSame assistance listing 93.853 as 579 awards here
HEAL Initiative: Pain Research Enhancement Program (PREP) (R15 Clinical Trial Optional)RFA-AT-25-003NIH93.853November 23, 2026$375,000Same assistance listing 93.853 as 579 awards here
Maximizing the Scientific Value of Data Generated by the Environmental Influences on Child Health Outcomes (ECHO) Program: Ruth L. Kirschstein National Research Service Award (NRSA) Individual Postdoctoral Fellowship (F32)RFA-OD-27-008NIH93.853December 2, 2026Not listedSame assistance listing 93.853 as 579 awards here
Emerging Global Leader Award (K43 Independent Clinical Trial Required)PAR-24-295NIH93.853December 3, 2026Not listedSame assistance listing 93.853 as 579 awards here
Emerging Global Leader Award (K43 Independent Clinical Trial Not Allowed)PAR-24-296NIH93.853December 3, 2026Not listedSame assistance listing 93.853 as 579 awards here
NIH Research Software Engineer (RSE) Award (R50 Clinical Trials Not Allowed)RFA-OD-24-011NIH93.853December 4, 2026Not listedSame assistance listing 93.853 as 579 awards here
Academic Research Enhancement Award (AREA) for Undergraduate-Focused Institutions (R15 Clinical Trial Required)PAR-24-214NIH93.853January 7, 2027$375,000Same assistance listing 93.853 as 579 awards here
HEAL Initiative: Studies to Enable Analgesic Discovery (R61/R33 - Clinical Trial Not Allowed)RFA-NS-25-023NIH93.853January 15, 2027$350,000Same assistance listing 93.853 as 579 awards here
HEAL Initiative: Integrative Management of Chronic Pain and OUD for Whole Recovery (IMPOWR): Research Centers (RM1 Clinical Trial Required)RFA-DA-28-011NIH93.853January 26, 2027Not listedSame assistance listing 93.853 as 579 awards here
HEAL Initiative: Integrative Management of chronic Pain and OUD for Whole Recovery (IMPOWR) - Building Engagement, Assistance, Capacity, Outreach, and Networks (BEACON) Center (U2C Clinical Trial Not Allowed)RFA-DA-28-012NIH93.853January 26, 2027Not listedSame assistance listing 93.853 as 579 awards here
Biomedical Research Environment and Sponsored Programs Administration Development (BRE-SPAD) Program (UC2- Clinical Trial Not Allowed)PAR-24-268NIH93.853January 27, 2027$500,000Same assistance listing 93.853 as 579 awards here
Translational Neural Devices (R61/R33 - Clinical Trial Optional)PAR-25-053NIH93.853January 28, 2027Not listedSame assistance listing 93.853 as 579 awards here
BRAIN Initiative: Preclinical Proof of Concept for Novel Recording and Modulation Technologies in the Human CNS (R18 - Clinical Trial Not Allowed)RFA-NS-24-031NIH93.853January 28, 2027$750,000Same assistance listing 93.853 as 579 awards here

Updated November 3, 2026. Read from NIH RePORTER ExPORTER and NSF Award Search. Published by NIH and NSF as U.S. government data. NIH awards are fiscal years 2021 to 2025 (NIH files published to 2026-07-09); NSF awards are fiscal years 2022 to 2026 (NSF files published to 2026-11-02). NIH amounts are the total cost of each fiscal year in the window; NSF amounts are the funds obligated in the window. Organizations are matched on the UEI. Open opportunities come from Grants.gov and match on agency and assistance listing number, and on the notice number NIH prints on an award. Free to reuse with credit to SpecStream under CC BY 4.0. Spot a wrong value? Write to [email protected] with the link to this page.