Data / Nonprofits / South Dakota / Sioux Falls / Health care
Health care nonprofits in Sioux Falls, SD: 63 registered with the IRS
63 health care nonprofits are registered with the IRS in Sioux Falls, SD, 59 of them 501(c)(3) charities; the 29 that report revenue took in $2.78 billion. The largest by revenue: Avera McKennan ($1.86 billion), Avera Health ($359.1 million), Avera Health Plans Inc ($307.1 million).
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Every organization, largest by revenue first
| Organization | Type | Since | Revenue | Assets | Filing |
|---|---|---|---|---|---|
| Avera McKennan | 501(c)(3) | 1942 | $1.86 billion | $2.09 billion | 2025-06 |
| Avera Health | 501(c)(3) | 1993 | $359.1 million | $2.58 billion | 2025-06 |
| Avera Health Plans Inc | 501(c)(4) | 2016 | $307.1 million | $97.1 million | 2024-12 |
| Avera at Home | 501(c)(3) | 1992 | $88.2 million | $72.8 million | 2025-06 |
| Sanford | 501(c)(3) | 2011 | $35.2 million | $792.7 million | 2024-12 |
| Hegg Memorial Hospital | 501(c)(3) | 1973 | $30.4 million | $60.4 million | 2025-06 |
| Lifescape Foundation | 501(c)(3) | 1979 | $22.6 million | $155.2 million | 2025-06 |
| Bethany Lutheran Home | 501(c)(3) | 1952 | $19.9 million | $31.4 million | 2025-06 |
| F-M Ambulance Service Inc | 501(c)(4) | 2003 | $17.7 million | $9.8 million | 2024-12 |
| Sanford Health Foundation North | 501(c)(3) | 1988 | $10.9 million | $107.3 million | 2024-12 |
| South Dakota Lions Eye and Tissue Bank Inc | 501(c)(3) | 1992 | $9.5 million | $12.3 million | 2025-06 |
| Lifescape | 501(c)(3) | 2015 | $6.1 million | $692,625 | 2025-06 |
| Sanford Health Foundation West | 501(c)(3) | 1987 | $4.7 million | $35.1 million | 2024-12 |
| Community Healthcare Association of the Dakotas | 501(c)(3) | 1985 | $4.3 million | $1.2 million | 2025-06 |
| South Dakota Foundation for Medical Care | 501(c)(3) | 1974 | $3.8 million | $2 million | 2024-12 |
| Heartland Health Resource Center | 501(c)(3) | 2013 | $1.8 million | $1.2 million | 2025-06 |
| Sanford Health Foundation of Northern Minnesota | 501(c)(3) | 1981 | $1.6 million | $10.2 million | 2024-12 |
| Fund for Advancement of Medical Education and Research | 501(c)(3) | 1986 | $668,045 | $4.5 million | 2025-06 |
| Prairie Heart Guest House Inc | 501(c)(3) | 2002 | $443,557 | $2 million | 2024-12 |
| Teddy Bear Den | 501(c)(3) | 2002 | $331,949 | $760,357 | 2024-12 |
| Midwest Street Medicine | 501(c)(3) | 2023 | $308,652 | $173,783 | 2025-06 |
| South Dakota Trauma Education Inc | 501(c)(3) | 2005 | $176,354 | $77,320 | 2025-12 |
| Immunize South Dakota | 501(c)(3) | 2021 | $153,955 | $32,963 | 2024-12 |
| Rare By Design Inc | 501(c)(3) | 2021 | $111,998 | $142,305 | 2025-12 |
| National Abstinence Clearing House | 501(c)(3) | 1998 | $95,980 | $19,288 | 2024-12 |
| Live Inspired 365 Inc | 501(c)(3) | 2023 | $65,823 | $144,243 | 2024-12 |
| Spirit Canyon Apartments Inc | 501(c)(3) | 1978 | $60,109 | $61,902 | 2024-12 |
| Freedom Dental Anesthesia Center | 501(c)(3) | 2024 | $40,658 | $22,042 | 2025-12 |
| Cosmopolitan Fund for Children | 501(c)(3) | 1997 | $23,558 | $310,679 | 2025-06 |
| Alleviate Mental Health Fund | 501(c)(3) | 2024 | |||
| Carroll Institute Foundation | 501(c)(3) | 1995 | $0 | $0 | 2026-06 |
| Community Health Worker Collaborative of South Dakota | 501(c)(3) | 2024 | $0 | $0 | 2024-12 |
| Deaf Bikers of America Foundation Inc | 501(c)(3) | 2017 | $0 | $0 | 2025-12 |
| Families Finding Joy | 501(c)(3) | 2024 | $11,618 | 2025-12 | |
| Good Samaritan-Sanford Community Health Services | 501(c)(3) | 1999 | |||
| H & H International Medical Specialty Education Foundation | 501(c)(3) | 2025 | $0 | $0 | 2025-12 |
| Help 4 Huhas | 501(c)(3) | 2019 | $0 | $0 | 2024-12 |
| Kids Cancer PT Communications | 501(c)(3) | 2025 | $0 | $0 | 2025-12 |
| Real Life Farming Inc | 501(c)(3) | 2020 | $0 | $0 | 2025-12 |
| Sanford | 501(c)(3) | 2001 | 2024-12 | ||
| Sanford | 501(c)(3) | 2011 | 2007-04 | ||
| Sanford | 501(c)(3) | 2011 | 2024-12 | ||
| Sanford | 501(c)(3) | 2011 | 2024-12 | ||
| Sanford | 501(c)(3) | 2011 | 2024-12 | ||
| Sanford | 501(c)(3) | 2011 | 2024-12 | ||
| Sanford | 501(c)(3) | 2011 | 2011-12 | ||
| Sanford | 501(c)(3) | 2011 | 2024-12 | ||
| Sanford | 501(c)(3) | 2011 | 2024-12 | ||
| Sanford | 501(c)(3) | 2011 | |||
| Sanford | 501(c)(3) | 2011 | 2011-06 | ||
| Sanford | 501(c)(3) | 2011 | 2023-12 | ||
| Sanford | 501(c)(3) | 2011 | |||
| Scope Foundation | 501(c)(3) | 2026 | |||
| Siouxland Dental & Implant Study Club Inc | 501(c)(3) | 2014 | $0 | $0 | 2024-12 |
| South Dakota Allergy Society | 501(c)(3) | 2012 | $0 | $0 | 2025-12 |
| South Dakota Association of Healthcare Quality | 501(c)(3) | 2020 | $0 | $0 | 2025-12 |
| South Dakota Chapter of the American Academy of Pediatrics | 501(c)(6) | 2000 | $0 | $0 | 2025-06 |
| South Dakota Perinatal Association Inc | 501(c)(3) | 2000 | $0 | $0 | 2026-01 |
| South Dakota Safe Childbirth Options | 501(c)(4) | 2005 | $0 | $0 | 2025-12 |
| Therapeautic Healing Institute | 501(c)(3) | 2005 | $0 | $0 | 2023-12 |
| Therapy Dogs Sioux Falls | 501(c)(3) | 2026 | $0 | $0 | 2025-12 |
| Thrivewell Foundation | 501(c)(3) | 2024 | $0 | $0 | 2024-12 |
| Tops Club Inc | 501(c)(3) | 2008 | $0 | $0 | 2026-03 |
Other causes in Sioux Falls, SD
- Religion-related 126
- Education 108
- Philanthropy, voluntarism and grantmaking foundations 104
- Human services 98
- Recreation and sports 85
- Arts, culture and humanities 72
- Community improvement and capacity building 64
- Public and societal benefit 28
- Youth development 25
- Food, agriculture and nutrition 19
- Mental health and crisis intervention 19
- Housing and shelter 17
- Animal-related 17
- Diseases, disorders and medical disciplines 16
- Environment 15
- Crime and legal-related 14
- Mutual and membership benefit 12
- International, foreign affairs and national security 12
- Civil rights, social action and advocacy 11
- Employment 8
- Medical research 8
- Public safety, disaster preparedness and relief 6
- Science and technology 3
Every nonprofit in Sioux Falls, SD · Health care nonprofits across the state · Nonprofits in every city of the state
Read from the IRS Exempt Organizations Business Master File, updated by the IRS on October 24, 2026 and rebuilt here every morning. Revenue and assets are from each organization's latest filing as the IRS lists it; the IRS record is the official one. Organizations only: no people are named on these pages.