Data / Nonprofits / South Dakota / Sioux Falls
Nonprofits in Sioux Falls, SD: 1,393 registered with the IRS
1,393 nonprofits are registered with the IRS in Sioux Falls, SD, 1,126 of them 501(c)(3) charities; the 465 that report revenue took in $12.62 billion. The largest by revenue: Sanford ($6.11 billion), Avera McKennan ($1.86 billion), Signatry Charitable Trust ($1.04 billion). Most common causes: religion-related (126), education (108), philanthropy, voluntarism and grantmaking foundations (104).
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The 500 largest by revenue
| Organization | Category | Type | Since | Revenue | Assets | Filing |
|---|---|---|---|---|---|---|
| Sanford | 501(c)(3) | 2011 | $6.11 billion | $4.27 billion | 2024-12 | |
| Avera McKennan | Health care | 501(c)(3) | 1942 | $1.86 billion | $2.09 billion | 2025-06 |
| Signatry Charitable Trust | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 2019 | $1.04 billion | $816.2 million | 2024-12 |
| The Evangelical Lutheran Good Samaritan Society | Human services | 501(c)(3) | 1955 | $1.01 billion | $970.4 million | 2024-12 |
| Margot and Tom Pritzker Science Foundation | Philanthropy, voluntarism and grantmaking foundations | 501(c)(4) | 2024 | $423.3 million | $449.6 million | 2024-12 |
| Avera Health | Health care | 501(c)(3) | 1993 | $359.1 million | $2.58 billion | 2025-06 |
| Avera Health Plans Inc | Health care | 501(c)(4) | 2016 | $307.1 million | $97.1 million | 2024-12 |
| Sanford Health Foundation | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 1997 | $214.4 million | $1.28 billion | 2024-12 |
| Augustana University Association | Education | 501(c)(3) | 1950 | $140.9 million | $365.4 million | 2025-07 |
| Avera at Home | Health care | 501(c)(3) | 1992 | $88.2 million | $72.8 million | 2025-06 |
| Childrens Care Hospital & School | 501(c)(3) | 1956 | $73.2 million | $75.4 million | 2025-06 | |
| Sioux Falls Area Community Foundation Inc | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 2001 | $50.6 million | $390.9 million | 2025-06 |
| South Dakota Achieve | Human services | 501(c)(3) | 1970 | $46.6 million | $30.6 million | 2025-06 |
| University of Sioux Falls | Education | 501(c)(3) | 1950 | $39.5 million | $96.1 million | 2025-06 |
| Childrens Home Society of South Dakota | Human services | 501(c)(3) | 1944 | $36.1 million | $58.9 million | 2025-06 |
| Sanford | Health care | 501(c)(3) | 2011 | $35.2 million | $792.7 million | 2024-12 |
| Feeding South Dakota | Food, agriculture and nutrition | 501(c)(3) | 1984 | $32.2 million | $22.9 million | 2025-06 |
| Hegg Memorial Hospital | Health care | 501(c)(3) | 1973 | $30.4 million | $60.4 million | 2025-06 |
| Lutheran Social Services of South Dakota | 501(c)(3) | 1963 | $27.2 million | $19.9 million | 2025-06 | |
| Dow Rummel Village | Human services | 501(c)(3) | 1968 | $26.2 million | $71.7 million | 2025-04 |
| Dakotabilities | Human services | 501(c)(3) | 1970 | $22.8 million | $27.5 million | 2025-06 |
| Lifescape Foundation | Health care | 501(c)(3) | 1979 | $22.6 million | $155.2 million | 2025-06 |
| Bethany Lutheran Home | Health care | 501(c)(3) | 1952 | $19.9 million | $31.4 million | 2025-06 |
| Southeastern Behavioral Healthcare | Mental health and crisis intervention | 501(c)(3) | 1953 | $18.7 million | $12.6 million | 2025-06 |
| Sioux Falls Christian Schools Association | Education | 501(c)(3) | 1978 | $17.8 million | $44.2 million | 2025-07 |
| F-M Ambulance Service Inc | Health care | 501(c)(4) | 2003 | $17.7 million | $9.8 million | 2024-12 |
| Childrens Home Foundation | Human services | 501(c)(3) | 1982 | $16.7 million | $179.1 million | 2025-06 |
| Sioux Falls Zoo & Aquarium | Animal-related | 501(c)(3) | 1958 | $16.1 million | $37.3 million | 2025-12 |
| Cedar Lake Village Inc | Housing and shelter | 501(c)(3) | 1999 | $15.9 million | $32.3 million | 2024-12 |
| Washington Pavilion Management Inc | Arts, culture and humanities | 501(c)(3) | 1996 | $15.4 million | $19.4 million | 2025-06 |
| Ssomusd Residency Corporation | Education | 501(c)(3) | 1993 | $13.1 million | $1.2 million | 2025-06 |
| Pendleton Manor Inc | 501(c)(3) | 1974 | $12.4 million | $2.5 million | 2024-12 | |
| Boys and Girls Clubs of Sioux Empire | Human services | 501(c)(3) | 1988 | $11.3 million | $11.2 million | 2025-12 |
| Sanford Health Foundation North | Health care | 501(c)(3) | 1988 | $10.9 million | $107.3 million | 2024-12 |
| East Dakota Educational Cooperative | 501(c)(3) | 1988 | $10.7 million | $4.7 million | 2025-06 | |
| Embe | 501(c)(3) | 1942 | $10.7 million | $8.3 million | 2024-12 | |
| Sioux Empire United Way Inc | 501(c)(3) | 1957 | $10.7 million | $14.2 million | 2025-12 | |
| McCrossan Boys Ranch | Mental health and crisis intervention | 501(c)(3) | 1972 | $10.6 million | $38.7 million | 2025-06 |
| University of South Dakota Research Park Inc | Education | 501(c)(3) | 2015 | $10.4 million | $22.7 million | 2024-12 |
| Evangelical Lutheran Good Samaritan Foundation | Religion-related | 501(c)(3) | 2023 | $10.2 million | $102.2 million | 2024-12 |
| Minnehaha Country Club | 501(c)(7) | 1934 | $9.7 million | $17 million | 2026-02 | |
| Regency Managed Properties Benefit Trust | 501(c)(9) | 1993 | $9.5 million | $1.9 million | 2024-12 | |
| South Dakota Lions Eye and Tissue Bank Inc | Health care | 501(c)(3) | 1992 | $9.5 million | $12.3 million | 2025-06 |
| Sioux Falls Development Foundation Inc | 501(c)(6) | 1957 | $9.3 million | $106.5 million | 2025-09 | |
| The Summit League Inc | 501(c)(3) | 1983 | $8.5 million | $11.2 million | 2025-06 | |
| Senior Citizens Services Inc | Human services | 501(c)(3) | 1968 | $7.1 million | $19.6 million | 2025-12 |
| Ronald McDonald House Charities of South Dakota Inc | Human services | 501(c)(3) | 1983 | $6.6 million | $12.1 million | 2024-12 |
| Carroll Institute | Mental health and crisis intervention | 501(c)(3) | 1982 | $6.4 million | $9.7 million | 2025-06 |
| South Dakota Life and Health Insurance Guaranty Association | 501(c)(6) | 1997 | $6.1 million | $9.1 million | 2024-12 | |
| Lifescape | Health care | 501(c)(3) | 2015 | $6.1 million | $692,625 | 2025-06 |
| Asone Ministries | Human services | 501(c)(3) | 2015 | $5.6 million | $3 million | 2025-12 |
| Helpline Center Inc | 501(c)(3) | 1975 | $5.6 million | $6.2 million | 2025-12 | |
| Center for Family Medicine | Education | 501(c)(3) | 1975 | $5.4 million | $6.1 million | 2026-06 |
| Friends of South Dakota Public Broadcasting | Arts, culture and humanities | 501(c)(3) | 1973 | $5.4 million | $12.7 million | 2025-06 |
| Glory House of Sioux Falls | 501(c)(3) | 1971 | $5.3 million | $3.7 million | 2025-12 | |
| Independent Living Choices | 501(c)(3) | 1985 | $5.2 million | $7.2 million | 2025-09 | |
| South Dakota Partners in Education | Education | 501(c)(3) | 2018 | $5.1 million | $1.5 million | 2025-06 |
| Girl Scouts Dakota Horizons Inc | Youth development | 501(c)(3) | 1955 | $4.9 million | $11.5 million | 2025-09 |
| Young Mens Christian Association | Human services | 501(c)(3) | 1942 | $4.9 million | $7.5 million | 2025-08 |
| Friends of Levitt Shell Sioux Falls Inc | Education | 501(c)(3) | 2016 | $4.7 million | $2.8 million | 2025-12 |
| Sanford Health Foundation West | Health care | 501(c)(3) | 1987 | $4.7 million | $35.1 million | 2024-12 |
| Luke Society | 501(c)(3) | 1966 | $4.6 million | $17.8 million | 2025-12 | |
| Greater Sioux Falls Chamber of Commerce | 501(c)(6) | 1942 | $4.6 million | $13.5 million | 2025-09 | |
| Habitat for Humanity International Inc | 501(c)(3) | 1987 | $4.5 million | $11.8 million | 2025-06 | |
| Community Healthcare Association of the Dakotas | Health care | 501(c)(3) | 1985 | $4.3 million | $1.2 million | 2025-06 |
| Experience Sioux Falls | Community improvement and capacity building | 501(c)(6) | 2022 | $3.9 million | $5.8 million | 2024-12 |
| South Dakota Foundation for Medical Care | Health care | 501(c)(3) | 1974 | $3.8 million | $2 million | 2024-12 |
| South Eastern Development Foundation | Community improvement and capacity building | 501(c)(3) | 2002 | $3.5 million | $28.7 million | 2025-12 |
| St Francis House of Sioux Falls | 501(c)(3) | 2018 | $3.5 million | $10.1 million | 2025-06 | |
| Lincoln County Rural Water Sys Inc | 501(c)(12) | 1974 | $3.5 million | $18.5 million | 2025-12 | |
| Sunnycrest Village | Housing and shelter | 501(c)(3) | 1964 | $3.3 million | $19.7 million | 2024-12 |
| South Dakota Urban Indian Health Inc Sduih | 501(c)(3) | 1978 | $3.2 million | $10.3 million | 2025-09 | |
| Call To Freedom Inc | Human services | 501(c)(3) | 2016 | $3.2 million | $3.9 million | 2024-12 |
| Lutherans Outdoors in South Dakota Inc | 501(c)(3) | 1987 | $3.2 million | $6.1 million | 2025-01 | |
| South Dakota Association of Healthcare Organizations | 501(c)(6) | 1956 | $3.2 million | $9.6 million | 2025-12 | |
| Mountain Plains Community Development Corporation | Community improvement and capacity building | 501(c)(3) | 2022 | $3.1 million | $2.2 million | 2025-09 |
| Compassion Child Care | Human services | 501(c)(3) | 2014 | $3 million | $2.1 million | 2024-12 |
| Make A Wish Foundation of South Dakota | 501(c)(3) | 1984 | $2.9 million | $14.4 million | 2025-08 | |
| The Society of St Vincent de Paul of Sioux Falls South Dakota | 501(c)(3) | 2010 | $2.8 million | $5.5 million | 2025-09 | |
| Sioux Empire Fair Association | Recreation and sports | 501(c)(5) | 1941 | $2.7 million | $1.9 million | 2024-12 |
| South Dakota Network Against Family Violence & Sexual Assault | 501(c)(3) | 1992 | $2.6 million | $981,341 | 2025-06 | |
| South Dakota Symphony Orchestra | Arts, culture and humanities | 501(c)(3) | 1967 | $2.6 million | $6 million | 2025-06 |
| American Coalition for Ethanol | 501(c)(6) | 1990 | $2.6 million | $646,382 | 2024-12 | |
| Special Olympics South Dakota Inc | Recreation and sports | 501(c)(3) | 1981 | $2.4 million | $6.5 million | 2024-12 |
| Sioux Falls Humane Society | Animal-related | 501(c)(3) | 1965 | $2.4 million | $29.1 million | 2024-12 |
| Dakota Alliance Soccer Club | Recreation and sports | 501(c)(3) | 1980 | $2.3 million | $2.3 million | 2024-06 |
| The Banquet | Food, agriculture and nutrition | 501(c)(3) | 2004 | $2.2 million | $7.1 million | 2025-06 |
| Atm Industry Association | Community improvement and capacity building | 501(c)(6) | 2003 | $2.2 million | $2.2 million | 2025-12 |
| Collision Ministries Inc | Youth development | 501(c)(3) | 2009 | $2.2 million | $1.1 million | 2024-06 |
| International Brotherhood of Electrical Workers | 501(c)(5) | 1940 | $2.1 million | $6.3 million | 2025-12 | |
| Mission Haiti | Religion-related | 501(c)(3) | 2006 | $2.1 million | $968,407 | 2025-06 |
| Alpha Center | Civil rights, social action and advocacy | 501(c)(3) | 1985 | $2.1 million | $4.8 million | 2024-12 |
| McCrossan Foundation Inc | 501(c)(3) | 1956 | $2.1 million | $27.2 million | 2025-06 | |
| Dakota Business Finance | Community improvement and capacity building | 501(c)(3) | 2006 | $2.1 million | $2.1 million | 2025-09 |
| Southeast Technical Institute Foundation | Education | 501(c)(3) | 1996 | $2 million | $3.6 million | 2025-06 |
| Great Bear Management Inc | 501(c)(4) | 1994 | $2 million | $1.5 million | 2026-04 | |
| East River Legal Services Corporation | Crime and legal-related | 501(c)(3) | 1971 | $2 million | $1 million | 2025-12 |
| South Dakota State Medical Association | 501(c)(6) | 1940 | $2 million | $12.3 million | 2025-12 | |
| Heartland Health Resource Center | Health care | 501(c)(3) | 2013 | $1.8 million | $1.2 million | 2025-06 |
| American Evangelistic Association | Religion-related | 501(c)(3) | 2003 | $1.8 million | $565,363 | 2024-12 |
| Christian Center Day Care Inc | Education | 501(c)(3) | 2018 | $1.8 million | $185,777 | 2025-07 |
| Ice Sports Association | Youth development | 501(c)(3) | 2010 | $1.7 million | $9.3 million | 2024-12 |
| Agricap Fund Inc | Food, agriculture and nutrition | 501(c)(5) | 2009 | $1.7 million | $25.5 million | 2024-12 |
| Sioux Empire Triage Center | Mental health and crisis intervention | 501(c)(3) | 2022 | $1.7 million | $4.5 million | 2024-12 |
| Karl & Mary Jo Wegner Health Science Information Center | Human services | 501(c)(3) | 1998 | $1.7 million | $9.2 million | 2025-06 |
| Junior Achievement of South Dakota | International, foreign affairs and national security | 501(c)(3) | 1994 | $1.7 million | $2.4 million | 2025-06 |
| South Dakota Trade Association | Community improvement and capacity building | 501(c)(6) | 2023 | $1.7 million | $1.1 million | 2025-09 |
| Sioux Falls Ministry Center | Human services | 501(c)(3) | 2009 | $1.6 million | $9.2 million | 2024-12 |
| Boy Scouts of America | 501(c)(3) | 1965 | $1.6 million | $7.5 million | 2025-12 | |
| Sanford Health Foundation of Northern Minnesota | Health care | 501(c)(3) | 1981 | $1.6 million | $10.2 million | 2024-12 |
| Realtor Association of the Sioux Empire Inc | 501(c)(6) | 1982 | $1.5 million | $2.3 million | 2024-11 | |
| Face It Together Inc | Mental health and crisis intervention | 501(c)(3) | 2010 | $1.5 million | $219,473 | 2024-12 |
| Dakota Rural Action | Education | 501(c)(3) | 1989 | $1.5 million | $1.6 million | 2024-12 |
| Family Service Inc | 501(c)(3) | 1960 | $1.5 million | $934,866 | 2024-12 | |
| South Dakota Corn Growers Association | 501(c)(5) | 1989 | $1.4 million | $4.8 million | 2025-06 | |
| Hills of Rest Memorial Park Inc | Mutual and membership benefit | 501(c)(13) | 1986 | $1.4 million | $6.5 million | 2026-01 |
| Kingdom Capital Fund | Religion-related | 501(c)(3) | 2008 | $1.4 million | $5.3 million | 2024-12 |
| South Dakota Health Care Association | 501(c)(6) | 1972 | $1.4 million | $2.6 million | 2025-06 | |
| South Dakota Producers Council | 501(c)(5) | 1972 | $1.4 million | $1.7 million | 2025-12 | |
| Lost and Found Association | Mental health and crisis intervention | 501(c)(3) | 2016 | $1.3 million | $181,084 | 2025-06 |
| Community Indoor Tennis Center Inc | Recreation and sports | 501(c)(3) | 2013 | $1.3 million | $7.9 million | 2024-12 |
| Home Builders Association of the Sioux Empire | 501(c)(6) | 1959 | $1.3 million | $2.3 million | 2024-12 | |
| The Compass Center | Crime and legal-related | 501(c)(3) | 1979 | $1.3 million | $989,555 | 2023-06 |
| Southeast Technical Institute Housing Foundation | Housing and shelter | 501(c)(3) | 2002 | $1.3 million | $4.1 million | 2024-12 |
| South Dakota Association of Healthcare Organizations Healthcar | Community improvement and capacity building | 501(c)(3) | 2016 | $1.2 million | $1.2 million | 2025-12 |
| Furniture Mission | Human services | 501(c)(3) | 2003 | $1.2 million | $3 million | 2024-12 |
| Transmission Access Policy Study Group Inc | Science and technology | 501(c)(6) | 2012 | $1.2 million | $415,362 | 2025-12 |
| Sioux Falls Youth Hockey Association | 501(c)(3) | 1998 | $1.2 million | $687,699 | 2025-04 | |
| Downtown Sioux Falls | 501(c)(4) | 1989 | $1.2 million | $1.2 million | 2024-12 | |
| United Food and Commercial Workers International Union | 501(c)(5) | 1941 | $1.2 million | $1.1 million | 2024-12 | |
| Northwestern Energy Welfare Benefit Trust | 501(c)(9) | 1996 | $1.2 million | $27.9 million | 2025-12 | |
| Sioux Falls State Theatre Company | Arts, culture and humanities | 501(c)(3) | 2006 | $1.2 million | $10.7 million | 2025-12 |
| Sioux Empire Baseball Association | Recreation and sports | 501(c)(3) | 2008 | $1.1 million | $116,688 | 2025-08 |
| VC Medical Endowment Trust | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 2015 | $1.1 million | $20.2 million | 2025-06 |
| South Dakota Veterans Alliance Inc | Public and societal benefit | 501(c)(7) | 2022 | $1.1 million | $120,362 | 2024-12 |
| Tallgrass Recovery & Sober Living Homes | Human services | 501(c)(3) | 2004 | $1.1 million | $906,192 | 2024-12 |
| South Dakota Military Heritage Alliance Inc | Public and societal benefit | 501(c)(3) | 2019 | $1 million | $11.1 million | 2024-12 |
| Hat Trick Hockey Corp | Recreation and sports | 501(c)(3) | 2016 | $1 million | $204,507 | 2024-12 |
| Friends of the Diocese of Tshumbe Dr Congo | Religion-related | 501(c)(3) | 2024 | $1 million | $327,360 | 2025-12 |
| Luther House of Study | Education | 501(c)(3) | 2022 | $983,586 | $1.8 million | 2025-12 |
| Bethesda Christian Counseling Midwest Inc | 501(c)(3) | 1993 | $971,243 | $267,498 | 2025-06 | |
| Giving Hope Inc | Human services | 501(c)(3) | 2017 | $920,674 | $247,720 | 2025-12 |
| Catholic Family Services | Human services | 501(c)(3) | 1946 | $917,346 | $1.1 million | 2025-06 |
| Independent Electrical Contractors-Dakotas Inc Education | Education | 501(c)(3) | 2012 | $907,596 | $293,772 | 2025-06 |
| El Riad Shriners | Mutual and membership benefit | 501(c)(10) | 1940 | $862,324 | $6.3 million | 2024-12 |
| South Dakota Golf Association Junior Golf Foundation | Youth development | 501(c)(3) | 1999 | $846,356 | $2.2 million | 2024-12 |
| First Lutheran Church Foundation | 501(c)(3) | 1971 | $844,132 | $16.5 million | 2024-12 | |
| Startup Sioux Falls | Community improvement and capacity building | 501(c)(4) | 2004 | $836,462 | $6.1 million | 2025-09 |
| South Dakota Golf Association | 501(c)(4) | 1971 | $819,828 | $632,774 | 2024-12 | |
| Woodlawn Cemetery Association | 501(c)(13) | 1962 | $781,268 | $10.2 million | 2025-10 | |
| Restoration Generation Inc | Crime and legal-related | 501(c)(3) | 2010 | $777,836 | $587,691 | 2025-12 |
| Sioux Falls Public Schools Education Foundation | Education | 501(c)(3) | 2009 | $768,046 | $1.3 million | 2024-12 |
| Tre Ministries | Religion-related | 501(c)(3) | 2018 | $745,568 | $3.6 million | 2025-12 |
| South Dakota Parent Connection | Human services | 501(c)(3) | 1986 | $718,164 | $447,691 | 2025-09 |
| South Dakota Development Corporation | Community improvement and capacity building | 501(c)(3) | 2025 | $717,194 | $208,539 | 2025-12 |
| South Dakota State Medical Association Foundation | Education | 501(c)(3) | 1961 | $693,729 | $7.6 million | 2025-12 |
| South Dakota Soybean Association | 501(c)(5) | 1983 | $693,157 | $1.2 million | 2025-06 | |
| Kingdom Boundaries Prison Aftercare Ministries Inc | Crime and legal-related | 501(c)(3) | 2020 | $692,752 | $1.8 million | 2024-12 |
| Fund for Advancement of Medical Education and Research | Health care | 501(c)(3) | 1986 | $668,045 | $4.5 million | 2025-06 |
| Lutheran Social Services of South Dakota Foundation Inc | 501(c)(3) | 1988 | $663,871 | $8.4 million | 2025-06 | |
| Arts South Dakota | Arts, culture and humanities | 501(c)(3) | 2015 | $649,373 | $341,333 | 2025-06 |
| South Dakota Voices for Peace | 501(c)(3) | 2020 | $646,144 | $134,409 | 2024-12 | |
| Sioux Falls Area Court Appointed Special Advocate Program | Civil rights, social action and advocacy | 501(c)(3) | 1995 | $644,544 | $548,970 | 2024-12 |
| Sioux Metro Growth Alliance | Community improvement and capacity building | 501(c)(6) | 2022 | $628,742 | $189,713 | 2024-12 |
| The Lincoln High School Bandparents Association | Youth development | 501(c)(3) | 2001 | $628,197 | $786,187 | 2025-05 |
| Emilys Hope Inc | Human services | 501(c)(3) | 2019 | $623,685 | $525,067 | 2024-12 |
| Sioux Empire Community Theatre Inc | Arts, culture and humanities | 501(c)(3) | 2004 | $600,083 | $297,301 | 2025-06 |
| Northern Prairies Land Trust | Environment | 501(c)(3) | 2000 | $595,730 | $500,766 | 2025-08 |
| Heidelberg Theological Seminary | Education | 501(c)(3) | 2002 | $578,408 | $288,777 | 2025-12 |
| Sculpturewalk Inc | Arts, culture and humanities | 501(c)(3) | 2007 | $569,811 | $3.1 million | 2024-12 |
| Sioux Falls Hope Coalition | Human services | 501(c)(3) | 2017 | $568,569 | $849,643 | 2026-06 |
| South Dakota Insurance Guaranty Association | 501(c)(6) | 1973 | $567,718 | $7.3 million | 2024-12 | |
| Vantage Point 3 Ministries | Religion-related | 501(c)(3) | 2003 | $566,134 | $182,589 | 2025-06 |
| Sioux Falls Swim Team Inc | Recreation and sports | 501(c)(3) | 1986 | $562,257 | $346,777 | 2025-08 |
| Shift Garage | Human services | 501(c)(3) | 2022 | $556,335 | $109,894 | 2024-12 |
| Fatty Acid Research Institute | 501(c)(3) | 2021 | $551,385 | $414,915 | 2024-12 | |
| Dow Rummel Foundation | Housing and shelter | 501(c)(3) | 2010 | $550,888 | $1.2 million | 2025-04 |
| Objective Zero Foundation | Mental health and crisis intervention | 501(c)(3) | 2016 | $540,123 | $447,128 | 2024-12 |
| Multifamily Impact Council | Housing and shelter | 501(c)(6) | 2022 | $534,140 | $207,970 | 2025-12 |
| Lil Troopers Learning Center | Human services | 501(c)(3) | 1992 | $533,145 | $170,770 | 2024-12 |
| Community Outreach Corporation | Human services | 501(c)(3) | 1992 | $530,051 | $164,949 | 2024-12 |
| South Dakota Junior Football Inc | 501(c)(3) | 1975 | $519,005 | $1.1 million | 2024-12 | |
| Center of Hope | Human services | 501(c)(3) | 2002 | $500,870 | $513,737 | 2026-03 |
| Underdog Foundation | Education | 501(c)(3) | 2014 | $494,824 | $63,435 | 2024-12 |
| Hometown Youth Sports Inc | Youth development | 501(c)(3) | 2024 | $492,174 | $472,524 | 2025-12 |
| Association for Protestant Reformed Education | Education | 501(c)(3) | 2014 | $479,705 | $1.2 million | 2025-07 |
| Central Baptist Church Foundation | Religion-related | 501(c)(3) | 2015 | $478,558 | $406,518 | 2025-07 |
| Washed Clean Addiction and Recovery Ministries | Mental health and crisis intervention | 501(c)(3) | 2019 | $465,327 | $1.4 million | 2024-11 |
| Westside Christian School Inc | Education | 501(c)(3) | 2016 | $452,411 | $243,146 | 2025-06 |
| Dakota Territory Gun Collectors Association Inc | Community improvement and capacity building | 501(c)(6) | 2003 | $447,650 | $351,689 | 2024-12 |
| Prairie Heart Guest House Inc | Health care | 501(c)(3) | 2002 | $443,557 | $2 million | 2024-12 |
| Sioux Falls Sports Authority | Recreation and sports | 501(c)(3) | 2008 | $441,709 | $647,384 | 2025-12 |
| Main Street Living Inc | Religion-related | 501(c)(3) | 2003 | $441,069 | $848,991 | 2025-12 |
| Leadership South Dakota | Education | 501(c)(3) | 2017 | $439,776 | $476,944 | 2026-05 |
| Sales & Marketing Executives Inc of Sioux Falls | 501(c)(6) | 1968 | $425,415 | $247,491 | 2025-06 | |
| Mary Chilton Dar Foundation | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 1985 | $414,949 | $7.8 million | 2025-11 |
| Paul Logan Ministries | Religion-related | 501(c)(3) | 1999 | $395,564 | $235,552 | 2024-12 |
| South Dakota Biotechnology Association | Community improvement and capacity building | 501(c)(6) | 2006 | $392,407 | $154,139 | 2025-12 |
| Eyes Up Sports Ministries | Recreation and sports | 501(c)(3) | 2017 | $389,425 | $454,342 | 2025-12 |
| Reach Literacy | 501(c)(3) | 1988 | $386,927 | $547,018 | 2024-12 | |
| National Association of State Investment Officers | Community improvement and capacity building | 501(c)(6) | 2004 | $382,756 | $465,084 | 2025-06 |
| Laborers International Union of North America | 501(c)(5) | 1968 | $365,550 | $114,577 | 2025-05 | |
| Dakota Institute for Business and Economic Analysis | Community improvement and capacity building | 501(c)(3) | 2021 | $363,844 | $100,424 | 2025-12 |
| Disabled American Veterans | 501(c)(4) | 1942 | $362,205 | $1.7 million | 2025-06 | |
| Grace Place Ministries | Religion-related | 501(c)(3) | 2023 | $360,192 | $135,071 | 2021-12 |
| Sioux Falls Cares Inc | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 1999 | $359,737 | $854,345 | 2025-12 |
| Sioux Falls Figure Skating Club | Recreation and sports | 501(c)(3) | 1997 | $358,483 | $123,125 | 2025-06 |
| South Dakota Automobile Dealers Association | 501(c)(6) | 1954 | $358,016 | $3.1 million | 2025-06 | |
| South Dakota Trucking Association | 501(c)(6) | 1944 | $354,345 | $696,034 | 2025-06 | |
| New Haven | Human services | 501(c)(3) | 1996 | $352,280 | $201,224 | 2024-12 |
| First Baptist Church Foundation | Religion-related | 501(c)(3) | 2003 | $349,182 | $2.3 million | 2024-12 |
| South Dakota Cpa Society | 501(c)(6) | 1973 | $349,181 | $361,765 | 2025-05 | |
| South Dakota Chapter Inc of the American Concrete Pavement Assoc | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 1993 | $344,871 | $328,219 | 2024-12 |
| Justice Through Empowerment Network South Dakota Foundation | Human services | 501(c)(3) | 2022 | $340,942 | $14,982 | 2024-06 |
| South Dakota State Soccer Association | 501(c)(3) | 1973 | $339,342 | $358,554 | 2024-12 | |
| Haiti Alive Inc | International, foreign affairs and national security | 501(c)(3) | 2015 | $335,785 | $5,006 | 2024-12 |
| Teddy Bear Den | Health care | 501(c)(3) | 2002 | $331,949 | $760,357 | 2024-12 |
| South Dakota Assoc of Plumbing Heating & Cooling Contractors Inc | 501(c)(6) | 1996 | $319,875 | $815,284 | 2025-12 | |
| Sioux Empire Housing Partnership Inc | Housing and shelter | 501(c)(3) | 1996 | $315,903 | $436,072 | 2025-09 |
| Greatlife Cares Foundation | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 2017 | $315,842 | $187,323 | 2024-12 |
| South Dakota Ready Mix Concrete Association | 501(c)(6) | 1970 | $310,748 | $295,198 | 2024-12 | |
| Wegner Arboretum Society | Arts, culture and humanities | 501(c)(3) | 2008 | $309,451 | $581,218 | 2024-12 |
| Midwest Street Medicine | Health care | 501(c)(3) | 2023 | $308,652 | $173,783 | 2025-06 |
| East River Foster Parent Network | Human services | 501(c)(3) | 2012 | $307,461 | $168,417 | 2025-12 |
| Split Rock Township Volunteer Fire Department | 501(c)(4) | 1984 | $303,717 | $1.1 million | 2025-08 | |
| Affordable Housing Solutions Inc | Housing and shelter | 501(c)(3) | 1995 | $302,024 | $8.5 million | 2025-09 |
| Toy Lending Library of South Dakota | Education | 501(c)(3) | 2018 | $292,475 | $192,054 | 2025-12 |
| International Association of Firefighters | 501(c)(5) | 1966 | $283,449 | $774,202 | 2024-12 | |
| Ground Works | Food, agriculture and nutrition | 501(c)(3) | 2016 | $280,460 | $335,411 | 2024-12 |
| Siouxpercon | Arts, culture and humanities | 501(c)(3) | 2017 | $276,430 | $27,243 | 2025-05 |
| South Dakota Multi-Housing Association | 501(c)(6) | 1991 | $275,791 | $138,216 | 2025-12 | |
| Sioux Empire Pit Bull Rescue Inc | Animal-related | 501(c)(3) | 2009 | $273,635 | $427,667 | 2025-12 |
| Messiah New Hope Lutheran Church | 501(c)(3) | 1987 | $270,914 | $2.8 million | 2025-12 | |
| Sioux Falls Airshow Inc | 501(c)(4) | 1990 | $266,719 | $723,628 | 2025-10 | |
| Children Rescues International | International, foreign affairs and national security | 501(c)(3) | 2016 | $265,523 | $125,353 | 2024-12 |
| Muslims Community Center of South Dakota | Religion-related | 501(c)(3) | 2012 | $262,846 | $1.7 million | 2024-12 |
| De Dios Es El Poder Ministerio de Restauracion | Religion-related | 501(c)(3) | 2021 | $256,732 | $1.1 million | 2024-12 |
| Transformation Project Inc | Human services | 501(c)(3) | 2019 | $256,695 | $277,666 | 2025-06 |
| Veterans of Foreign Wars of the United States Dept of South Dakota | 501(c)(4) | 1964 | $255,621 | $681,280 | 2025-12 | |
| South Dakota Parkinson Foundation | Diseases, disorders and medical disciplines | 501(c)(3) | 2017 | $253,164 | $354,021 | 2025-12 |
| Pi Beta Phi | Education | 501(c)(7) | 2007 | $252,440 | $674,801 | 2025-08 |
| Paralyzed Veterans of America | Public and societal benefit | 501(c)(3) | 2013 | $251,015 | $864,513 | 2025-09 |
| Sioux Falls Tennis Association Inc | Recreation and sports | 501(c)(3) | 1994 | $248,724 | $69,742 | 2025-12 |
| Almost Home Canine Rescue | Animal-related | 501(c)(3) | 2025 | $246,680 | $26,221 | 2025-12 |
| Judy Shaw Foundation Inc | Human services | 501(c)(3) | 2015 | $242,262 | $23,135 | 2025-12 |
| East Dakota Educational Foundation | 501(c)(3) | 1994 | $241,290 | $2.1 million | 2025-12 | |
| Psi Chapter of Alpha Phi Corporation | 501(c)(7) | 1997 | $238,870 | $879,439 | 2025-06 | |
| Legacy Booster Club | Recreation and sports | 501(c)(3) | 2015 | $238,015 | $27,978 | 2025-05 |
| Falls Area Singletrack Inc | Recreation and sports | 501(c)(3) | 2018 | $237,786 | $125,057 | 2025-12 |
| Presidents Bowl Committee of Sioux Falls Inc | Recreation and sports | 501(c)(3) | 1997 | $229,925 | $9,786 | 2025-03 |
| Dakota Dachshund Rescue Inc | Animal-related | 501(c)(3) | 2019 | $226,531 | $225,893 | 2025-03 |
| Ancient Free & Accepted Masons of South Dakota Grand Lodge | 501(c)(10) | 1971 | $221,405 | $7.1 million | 2024-04 | |
| South Dakota Planning Group Initiative | Community improvement and capacity building | 501(c)(6) | 2015 | $220,864 | $240,208 | 2024-12 |
| Sioux Residential Services Inc | Human services | 501(c)(3) | 1985 | $217,138 | $317,349 | 2025-06 |
| Project C A R Call-A-Ride | Human services | 501(c)(3) | 1989 | $216,810 | $259,831 | 2025-12 |
| Among Foundation | International, foreign affairs and national security | 501(c)(3) | 1995 | $213,137 | $142,358 | 2025-09 |
| Jeremiah 29 11 Inc | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 2000 | $213,036 | $552,171 | 2024-12 |
| Feisty Fighters Inc | Medical research | 501(c)(3) | 2011 | $210,715 | $518,251 | 2024-12 |
| American Legion | 501(c)(19) | 1946 | $210,688 | $1.1 million | 2026-04 | |
| Agriculture United for South Dakota | Food, agriculture and nutrition | 501(c)(5) | 2005 | $209,569 | $335,484 | 2025-12 |
| Lights Up Ministries Inc | Religion-related | 501(c)(3) | 2002 | $208,228 | $109,986 | 2025-12 |
| Disabled American Veterans | 501(c)(4) | 1942 | $208,015 | $559,971 | 2025-06 | |
| South Dakota Right To Life Committee Inc | Civil rights, social action and advocacy | 501(c)(4) | 1984 | $205,881 | $219,607 | 2025-12 |
| Lutheran Housing Corporation Prairie Lake Apartments | Housing and shelter | 501(c)(3) | 2020 | $201,227 | $331,344 | 2024-12 |
| First United Methodist Church Foundation of Sioux Falls | 501(c)(3) | 1980 | $200,791 | $4.6 million | 2025-12 | |
| South Dakota Biotechnology Council | Science and technology | 501(c)(3) | 2014 | $200,676 | $34,739 | 2025-12 |
| Dakota Spirit Cheer Parents Inc | Recreation and sports | 501(c)(3) | 2008 | $195,319 | $96,978 | 2025-05 |
| Bridging the Opportunity Gap | Public and societal benefit | 501(c)(3) | 2024 | $194,940 | $34,263 | 2024-12 |
| Folds of Honor Foundation | Education | 501(c)(3) | 2015 | $193,896 | $16,647 | 2025-12 |
| Canyon Ferry-Broadwater County Trust | Recreation and sports | 501(c)(3) | 2000 | $192,584 | $2.5 million | 2024-12 |
| Nami South Dakota | 501(c)(3) | 1988 | $191,296 | $127,194 | 2025-12 | |
| Hope Has Arrived | Religion-related | 501(c)(3) | 2018 | $190,828 | $125,997 | 2025-12 |
| Pepper Entertainment Foundation Inc | Youth development | 501(c)(3) | 2023 | $190,537 | $72,224 | 2025-12 |
| Lincoln High School Booster Club Inc | Education | 501(c)(3) | 1998 | $189,052 | $252,425 | 2025-06 |
| Covenant Classical School | Education | 501(c)(3) | 2022 | $188,826 | $85,918 | 2025-06 |
| Sertoma Inc | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 1964 | $188,506 | $294,090 | 2025-06 |
| Rotary International | 501(c)(4) | 1942 | $186,905 | $73,413 | 2025-06 | |
| South Dakota Society of American Institute of Architects | Community improvement and capacity building | 501(c)(6) | 2014 | $186,887 | $205,335 | 2024-12 |
| Health Connect of South Dakota Inc | Education | 501(c)(3) | 1997 | $186,869 | $74,674 | 2025-02 |
| Friends of the Big Sioux River | Environment | 501(c)(3) | 2015 | $186,258 | $201,961 | 2025-12 |
| Foster605 | Human services | 501(c)(3) | 2024 | $182,544 | $53,645 | 2025-12 |
| Howard Wood Dakota Relays | 501(c)(3) | 1983 | $180,743 | $257,657 | 2024-12 | |
| Kids Against Hunger-Sioux Falls | Human services | 501(c)(3) | 2009 | $178,104 | $63,120 | 2025-12 |
| Friends of Sharing the Dream in Guatemala | International, foreign affairs and national security | 501(c)(3) | 2004 | $177,689 | $212,525 | 2024-12 |
| South Dakota Ethanol Producers Association Inc | Community improvement and capacity building | 501(c)(6) | 2003 | $177,596 | $25,040 | 2024-12 |
| Post 307 Baseball | Recreation and sports | 501(c)(3) | 2014 | $176,669 | $49,014 | 2024-12 |
| South Dakota Lions Foundation Inc | Diseases, disorders and medical disciplines | 501(c)(3) | 1966 | $176,396 | $910,475 | 2025-06 |
| South Dakota Trauma Education Inc | Health care | 501(c)(3) | 2005 | $176,354 | $77,320 | 2025-12 |
| El Riad Shriners Group Return | 501(c)(10) | 1940 | $174,298 | $497,940 | 2024-12 | |
| Multifamily Impact Council Research Fund | Housing and shelter | 501(c)(3) | 2024 | $172,667 | $172,627 | 2024-12 |
| Lambda Chi Alpha Fraternity Inc | 501(c)(7) | 1967 | $172,319 | $9,522 | 2025-06 | |
| Poland Evangelical Mission | Religion-related | 501(c)(3) | 2004 | $172,248 | $52,641 | 2025-12 |
| Groove Inc | Arts, culture and humanities | 501(c)(3) | 2005 | $168,489 | $147,073 | 2025-10 |
| Parent Advocates for Spanish Immersion Inc | Arts, culture and humanities | 501(c)(3) | 2010 | $167,976 | $368,616 | 2024-12 |
| American Federation of Labor & Congress of Industrial Orgs | 501(c)(5) | 1956 | $166,909 | $106,124 | 2025-12 | |
| Accurate and Conscious Education Academy | Education | 501(c)(3) | 2026 | $165,018 | $11,190 | 2022-08 |
| Evermore Blooms Co | Human services | 501(c)(3) | 2021 | $163,056 | $43,947 | 2025-12 |
| South Dakota Wind Energy Association | Community improvement and capacity building | 501(c)(6) | 2010 | $160,910 | $78,335 | 2025-12 |
| Harmony South Dakota Inc | Arts, culture and humanities | 501(c)(3) | 2013 | $160,830 | $188,731 | 2025-06 |
| Accelerate | Diseases, disorders and medical disciplines | 501(c)(3) | 2009 | $159,214 | $121,833 | 2024-12 |
| Sioux Empire Kennel Club Inc | 501(c)(4) | 1966 | $159,114 | $220,073 | 2024-12 | |
| Cosmopolitan International | Human services | 501(c)(4) | 2025 | $158,975 | $557,419 | 2025-06 |
| Round Up America Inc | Arts, culture and humanities | 501(c)(3) | 2016 | $154,492 | $8,937 | 2025-12 |
| Immunize South Dakota | Health care | 501(c)(3) | 2021 | $153,955 | $32,963 | 2024-12 |
| Sound of the Trumpet | Religion-related | 501(c)(3) | 2003 | $152,047 | $127,568 | 2024-12 |
| Naomi Project | Civil rights, social action and advocacy | 501(c)(3) | 2018 | $150,944 | $21,402 | 2024-12 |
| Stockyards Plaza Inc | Arts, culture and humanities | 501(c)(3) | 2014 | $149,752 | $2.5 million | 2024-12 |
| Lunch Is Served Inc | Food, agriculture and nutrition | 501(c)(3) | 2023 | $149,323 | $264,826 | 2025-12 |
| Mockingbird Flying Club | Community improvement and capacity building | 501(c)(7) | 2009 | $148,334 | $567,708 | 2025-12 |
| New Roots Ministry | Religion-related | 501(c)(3) | 2012 | $147,863 | $95,682 | 2025-12 |
| National Network of Abortion Funds | 501(c)(3) | 1994 | $146,334 | $242,165 | 2026-06 | |
| Sioux Empire TNR Coalition | Animal-related | 501(c)(3) | 2023 | $143,321 | $4,036 | 2025-12 |
| Pickerel Lake Conservancy | Environment | 501(c)(3) | 2013 | $140,844 | $431,700 | 2024-12 |
| Veterans of Foreign Wars John M Bliss Post 628 | 501(c)(4) | 1945 | $140,688 | $1.9 million | 2026-03 | |
| Sioux Falls Concerts Association | Arts, culture and humanities | 501(c)(3) | 2007 | $139,448 | $200,574 | 2025-08 |
| Employment Disability Resources | Community improvement and capacity building | 501(c)(3) | 2014 | $138,319 | $94,048 | 2024-12 |
| Hawthorne Hall Inc | Human services | 501(c)(3) | 2002 | $135,095 | $344,868 | 2025-12 |
| Valley Telecommunicationscooperative Association Inc Veba Trust | Mutual and membership benefit | 501(c)(9) | 2008 | $134,985 | $1.2 million | 2025-12 |
| Izaak Walton League of America Inc | 501(c)(3) | 1985 | $134,664 | $460,111 | 2024-12 | |
| Little League Baseball Inc | Recreation and sports | 501(c)(3) | 1981 | $134,556 | $139,250 | 2024-12 |
| Family Connection | Housing and shelter | 501(c)(3) | 1995 | $133,844 | $343,362 | 2025-06 |
| Crooks Conservation & Gun Club Inc | Environment | 501(c)(4) | 2021 | $130,966 | $300,661 | 2025-09 |
| Gathering Well | Human services | 501(c)(3) | 2020 | $130,486 | $87,435 | 2024-12 |
| Underground House of Prayer | Religion-related | 501(c)(3) | 2001 | $130,445 | $82,753 | 2025-12 |
| Sioux Empire Fastpitch Softball Association Inc | Recreation and sports | 501(c)(3) | 1974 | $130,304 | $81,480 | 2024-12 |
| Independent Electrical Contractors Inc | 501(c)(6) | 1978 | $130,016 | $246,721 | 2025-06 | |
| Hands & Voices South Dakota | Human services | 501(c)(3) | 2020 | $125,237 | $138,069 | 2025-12 |
| Faith Temple Food Giveaway | Food, agriculture and nutrition | 501(c)(3) | 2018 | $124,926 | $63,211 | 2025-03 |
| Chrysalis Collective | Education | 501(c)(3) | 2018 | $124,742 | $10,278 | 2024-12 |
| Transformation Project Advocacy Network Inc | Civil rights, social action and advocacy | 501(c)(4) | 2023 | $124,310 | $159,198 | 2025-06 |
| Journey of Hope Inc | Human services | 501(c)(3) | 2021 | $124,002 | $59,742 | 2025-12 |
| Sioux Falls Mens 12-Inch Slow Pitch Softball League Inc | 501(c)(7) | 1981 | $123,725 | $8,362 | 2025-12 | |
| Iglesia Bautista Cross Pointe | Religion-related | 501(c)(3) | 2020 | $123,323 | $237,579 | 2025-12 |
| Sioux Falls Chargers Baseball Association | Recreation and sports | 501(c)(3) | 2022 | $121,822 | $36,892 | 2025-12 |
| Legacy Foundation | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 2023 | $120,277 | $81,674 | 2025-09 |
| Transforming Wealth | Human services | 501(c)(3) | 2021 | $118,934 | $98,102 | 2024-12 |
| Jefferson High School Chorus Boosters | Education | 501(c)(3) | 2022 | $117,645 | $38,058 | 2026-06 |
| Breathe Bravely Inc | Diseases, disorders and medical disciplines | 501(c)(3) | 2015 | $115,369 | $25,451 | 2024-12 |
| Fraternal Order of Police | 501(c)(8) | 1972 | $114,020 | $394,169 | 2024-12 | |
| Sioux Falls Education Association | Employment | 501(c)(5) | 2020 | $113,816 | $137,722 | 2025-08 |
| Senior Companion Fund | 501(c)(3) | 1985 | $112,456 | $1.8 million | 2025-12 | |
| Band of Brothers - South Dakota | Religion-related | 501(c)(3) | 2013 | $112,359 | $67,369 | 2025-12 |
| South Dakota Sigma Chapter House Association | 501(c)(7) | 2002 | $112,098 | $3.5 million | 2025-06 | |
| Rare By Design Inc | Health care | 501(c)(3) | 2021 | $111,998 | $142,305 | 2025-12 |
| Diamonds Booster Club | Recreation and sports | 501(c)(3) | 2008 | $111,156 | $61,244 | 2026-05 |
| Our Saviors Lutheran Church Foundation | 501(c)(3) | 1980 | $110,419 | $3.7 million | 2024-12 | |
| South Dakota Scholarship Foundation | Recreation and sports | 501(c)(4) | 2012 | $109,807 | $100,063 | 2025-12 |
| Hope for the Hopeless Organization H20 | International, foreign affairs and national security | 501(c)(3) | 2018 | $109,462 | $23,619 | 2025-12 |
| Health Policy Consortium | Employment | 501(c)(6) | 2005 | $109,375 | $232,558 | 2025-12 |
| Sioux Falls Pride | Diseases, disorders and medical disciplines | 501(c)(3) | 2015 | $108,782 | $69,118 | 2024-12 |
| Allcatsrescue | Animal-related | 501(c)(3) | 2009 | $107,058 | $14,783 | 2025-07 |
| American Advertising Federation South Dakota | Community improvement and capacity building | 501(c)(6) | 2007 | $106,702 | $84,600 | 2026-06 |
| Fraternal Order of Police Labor Council | Employment | 501(c)(5) | 2010 | $104,144 | $234,196 | 2025-12 |
| Masonic Building Association of Sioux Falls | 501(c)(2) | 1971 | $103,930 | $1.3 million | 2024-12 | |
| Shakarparian Education Welfare | Education | 501(c)(3) | 2020 | $103,050 | $149,618 | 2025-12 |
| Pension Fund Data Exchange LTD | Community improvement and capacity building | 501(c)(6) | 2002 | $103,032 | $315,354 | 2025-06 |
| Mount Pleasant Cemetery Association of Sioux Falls | Mutual and membership benefit | 501(c)(13) | 2026 | $102,935 | $300,324 | 2025-12 |
| United States Bowling Congress Inc | Recreation and sports | 501(c)(3) | 2004 | $102,921 | $15,058 | 2025-07 |
| South Dakota Law Enforcement Charities | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 1996 | $102,809 | $118,517 | 2025-12 |
| Charis Ministry Partners | Food, agriculture and nutrition | 501(c)(3) | 2009 | $100,899 | $85,222 | 2025-12 |
| Well-Being Connections | Youth development | 501(c)(3) | 2020 | $100,123 | $92,804 | 2024-12 |
| Gamma Alpha Alumni Corporation Beta Theta Pi South Dakota | Education | 501(c)(7) | 2024 | $99,649 | $461,127 | 2025-05 |
| South Dakota High School Boys & Girls Basketball Hall of Fame | Arts, culture and humanities | 501(c)(3) | 2010 | $97,399 | $323,627 | 2025-12 |
| Empire Mental Health Support | 501(c)(3) | 2021 | $96,421 | $42,464 | 2025-12 | |
| National Abstinence Clearing House | Health care | 501(c)(3) | 1998 | $95,980 | $19,288 | 2024-12 |
| SHRM South Dakota State Council Inc | Community improvement and capacity building | 501(c)(6) | 2001 | $95,491 | $140,726 | 2025-12 |
| South Dakota Career Planning and Placement Association | 501(c)(4) | 1996 | $95,084 | $215,258 | 2025-06 | |
| Bethany Lutheran Foundation Inc | Housing and shelter | 501(c)(3) | 2007 | $94,762 | $608,155 | 2025-06 |
| Coo Football Legacy Association | Recreation and sports | 501(c)(7) | 2024 | $93,441 | $84,539 | 2024-12 |
| Sioux Falls Estate Planning Council | Community improvement and capacity building | 501(c)(6) | 2004 | $92,740 | $77,786 | 2026-05 |
| American College of Physicians | 501(c)(3) | 1977 | $92,396 | $86,209 | 2025-06 | |
| Sioux Empire Home Builders Care Foundation | 501(c)(3) | 2007 | $91,497 | $805,966 | 2024-12 | |
| Avera McKennan Hospital Medical Staff | Community improvement and capacity building | 501(c)(6) | 2009 | $89,975 | $48,161 | 2026-06 |
| National Society of the Daughters of the American Revolution | 501(c)(3) | 1949 | $87,937 | $28,942 | 2025-12 | |
| Regency Cares | Human services | 501(c)(3) | 2018 | $87,685 | $207,947 | 2025-12 |
| American Postal Workers Union | 501(c)(5) | 1973 | $86,187 | $74,041 | 2025-12 | |
| Clubcentral Volleyball | Recreation and sports | 501(c)(3) | 2019 | $85,673 | $28,552 | 2025-11 |
| Sioux Falls Arts Council | 501(c)(3) | 1986 | $85,594 | $219,382 | 2025-12 | |
| Imahelps Ecuador | International, foreign affairs and national security | 501(c)(3) | 2024 | $85,230 | $20,030 | 2025-12 |
| Bread Break | Food, agriculture and nutrition | 501(c)(3) | 2022 | $84,679 | $143,356 | 2024-12 |
| Royal Order of Jesters | 501(c)(10) | 1941 | $84,520 | $47,661 | 2025-12 | |
| Delta Gamma Chapter Association | 501(c)(7) | 1940 | $83,910 | $770,284 | 2026-05 | |
| Festival of Bands - U S A | 501(c)(3) | 1989 | $83,085 | $42,613 | 2025-12 | |
| Minnehaha Archers Inc | 501(c)(7) | 1991 | $82,984 | $259,230 | 2024-12 | |
| Kashale Orphanage Inc | Housing and shelter | 501(c)(3) | 2008 | $82,525 | $368,764 | 2025-12 |
| Hudson Housing Corporation | Housing and shelter | 501(c)(3) | 1998 | $81,799 | $300,507 | 2024-12 |
| Sioux Falls Society for Human Resource Management | 501(c)(6) | 1990 | $79,435 | $121,293 | 2024-12 | |
| Sioux Falls Curling | Recreation and sports | 501(c)(3) | 2016 | $78,612 | $122,888 | 2025-06 |
| Happy the Dog Ministry Inc | Religion-related | 501(c)(3) | 2007 | $78,272 | $33,931 | 2026-03 |
| South Dakota States Attorneys Association | 501(c)(6) | 1986 | $76,601 | $39,780 | 2025-12 | |
| Sioux Falls Pickleball Club | Recreation and sports | 501(c)(3) | 2015 | $76,412 | $105,803 | 2025-12 |
| South Dakota Right To Life Committee Educational Fund | 501(c)(3) | 1984 | $74,908 | $17,940 | 2025-12 | |
| National Association of Letter Carriers | 501(c)(5) | 1964 | $73,422 | $32,426 | 2024-12 | |
| John Harris Elementary School Parent Teacher Organization | Education | 501(c)(3) | 2020 | $71,699 | $76,322 | 2025-12 |
| Project Management Institute | 501(c)(6) | 2001 | $71,007 | $106,725 | 2025-12 | |
| South Dakota Association for the Deaf Foundation Inc | Human services | 501(c)(3) | 2017 | $70,518 | $1.1 million | 2025-12 |
| Patton Ministries | Religion-related | 501(c)(3) | 2003 | $70,349 | $46,830 | 2024-12 |
| Nurse Practitioner Association of South Dakota | Community improvement and capacity building | 501(c)(6) | 2000 | $70,327 | $255,968 | 2025-12 |
| Sunshine State Chapter No 190 Order of Ahepa | Mutual and membership benefit | 501(c)(10) | 2025 | $70,232 | $464,086 | 2025-12 |
| Great Plains Medical Research Foundation | 501(c)(3) | 1990 | $70,024 | $330,458 | 2025-12 | |
| Washington Senior High School Booster Club | 501(c)(3) | 1976 | $67,632 | $79,191 | 2025-06 | |
| United States Junior Chamber of Commerce | 501(c)(4) | 1981 | $67,496 | $46,448 | 2024-12 | |
| Camp Gilbert Inc | Human services | 501(c)(3) | 2007 | $66,838 | $384,307 | 2025-12 |
| Community Action for Veterans | Human services | 501(c)(3) | 2022 | $66,352 | $10,789 | 2025-06 |
| American Federation of Labor and Congress of Industrial Orgs | 501(c)(5) | 1956 | $66,042 | $170,722 | 2024-12 | |
| Live Inspired 365 Inc | Health care | 501(c)(3) | 2023 | $65,823 | $144,243 | 2024-12 |
| Jericho Wall | Religion-related | 501(c)(3) | 2024 | $64,204 | $2,872 | 2024-12 |
| South Dakota Chapter of the American Physical Therapy Assoc | 501(c)(6) | 1977 | $63,743 | $329,572 | 2025-12 | |
| South Dakota Electrical Council | 501(c)(6) | 1966 | $63,411 | $75,007 | 2025-06 | |
| Hayward Memorial Testamentary Trust | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 1959 | $63,319 | $1.1 million | 2025-12 |
| South Dakota Library Association | Education | 501(c)(3) | 1984 | $62,783 | $152,474 | 2024-12 |
| Lightsout | Religion-related | 501(c)(3) | 2009 | $61,349 | $24,092 | 2024-12 |
| Spirit Canyon Apartments Inc | Health care | 501(c)(3) | 1978 | $60,109 | $61,902 | 2024-12 |
| Rasdak Inc | Recreation and sports | 501(c)(3) | 2014 | $58,865 | $64,529 | 2025-12 |
| South Dakota Renegades Inc | Recreation and sports | 501(c)(3) | 2016 | $58,148 | $24,249 | 2025-08 |
| Communication Workers of America | Employment | 501(c)(5) | 1951 | $57,604 | $102,745 | 2025-09 |
| Lincoln High School Graduation Organization | Youth development | 501(c)(3) | 2003 | $57,015 | $21,080 | 2026-06 |
| Titan Foundation | Public safety, disaster preparedness and relief | 501(c)(3) | 2022 | $55,774 | $20,167 | 2025-12 |
| Horizon Pto | Youth development | 501(c)(3) | 2023 | $55,652 | $23,071 | 2025-12 |
| South Dakota Association of the Deaf Inc | Human services | 501(c)(3) | 2003 | $55,498 | $54,035 | 2025-06 |
| International Association of Lions Clubs | 501(c)(4) | 1961 | $54,137 | $121,006 | 2025-06 | |
| Laborers International Union of North America | 501(c)(5) | 1940 | $51,520 | $306,978 | 2025-12 | |
| Arabian Horse Society of South Dakota Inc | 501(c)(4) | 1991 | $50,571 | $50,972 | 2025-10 | |
| Abate of South Dakota | 501(c)(4) | 1986 | $50,182 | $46,007 | 2025-12 | |
| James Daeh Foundation | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 2018 | $50,000 | $150,000 | 2024-12 |
| South Dakota Masonic Charities | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 2026 | $47,135 | $973,685 | 2019-12 |
| Harrisburg Endeavor Pto | Education | 501(c)(3) | 2019 | $45,838 | $39,481 | 2025-06 |
| Badger Clark Foundation | Arts, culture and humanities | 501(c)(3) | 2019 | $45,596 | $16,621 | 2025-12 |
| Lutheran Financial Managers Association | 501(c)(6) | 1997 | $45,307 | $20,623 | 2025-12 | |
| Wonders Evangelistic Inc | Religion-related | 501(c)(3) | 2023 | $45,195 | $371,522 | 2025-12 |
| United Brotherhood of Carpenters & Joiners of America | 501(c)(5) | 1953 | $45,036 | $187,112 | 2025-06 | |
| International Alliance Theatrical Stage Employees & Moving Picture | 501(c)(5) | 1941 | $44,035 | $50,051 | 2024-12 | |
| Sioux Falls Washington High School Marching Band Boosters | Education | 501(c)(3) | 1998 | $43,502 | $41,736 | 2025-06 |
| Freedom Dental Anesthesia Center | Health care | 501(c)(3) | 2024 | $40,658 | $22,042 | 2025-12 |
| Kiwanis International Inc | 501(c)(4) | 1940 | $39,751 | $38,322 | 2025-09 | |
| Prairie Payee Services Inc | 501(c)(3) | 2014 | $39,396 | $587 | 2026-05 | |
| American Federation of Government Employees | 501(c)(5) | 1940 | $37,406 | $22,931 | 2024-12 | |
| Yaks Give Back Foundation | 501(c)(3) | 2020 | $36,053 | $34,985 | 2025-12 | |
| Sioux Falls Jefferson High School Booster Club Inc | Education | 501(c)(3) | 2021 | $34,959 | $49,530 | 2023-06 |
| Sioux Falls Roosevelt High School Bands Parents Association Inc | Arts, culture and humanities | 501(c)(3) | 2016 | $34,793 | $76,785 | 2025-05 |
| Amalgamated Transit Union | 501(c)(5) | 1971 | $33,810 | $71,706 | 2025-06 | |
| Sioux Falls Washington High School Chorus Boosters | Education | 501(c)(3) | 2007 | $33,740 | $69,034 | 2025-06 |
| Sunnycrest Village Foundation | 501(c)(3) | 1993 | $33,527 | $454,891 | 2024-12 | |
| Jakes Summer Classic | Human services | 501(c)(3) | 2020 | $30,165 | $102 | 2025-12 |
| Jy6 Foundation | Diseases, disorders and medical disciplines | 501(c)(3) | 2015 | $28,900 | $50,068 | 2024-12 |
| Rich Vogler Scholarship Foundation Inc | Education | 501(c)(3) | 1992 | $28,049 | $302,807 | 2025-12 |
| Transept | Arts, culture and humanities | 501(c)(3) | 2018 | $27,533 | $8,824 | 2025-06 |
| Sioux Empire Realtor for Kids | Youth development | 501(c)(3) | 2009 | $27,528 | $37,562 | 2024-11 |
| Lets Skate | Recreation and sports | 501(c)(3) | 2021 | $27,432 | $40,450 | 2025-12 |
| R F Pettigrew Parent Teacher Organization | Education | 501(c)(3) | 2009 | $26,292 | $18,182 | 2025-06 |
| South Dakota Rock and Roll Music Association | Arts, culture and humanities | 501(c)(3) | 2009 | $24,310 | $44,806 | 2024-12 |
| Cosmopolitan Fund for Children | Health care | 501(c)(3) | 1997 | $23,558 | $310,679 | 2025-06 |
| South Dakota Foundation of Independent Colleges | 501(c)(3) | 1954 | $20,500 | $6,996 | 2025-12 | |
| Gomadis International | Religion-related | 501(c)(3) | 2007 | $19,149 | $1 | 2025-12 |
| Discovery Elementary Pto Incorporated | Education | 501(c)(3) | 2008 | $13,825 | $79,838 | 2026-06 |
| Chua Ky Vien the Wonderful Garden Buddhist Meditation Center Corp | Religion-related | 501(c)(3) | 2014 | $9,972 | $9,583 | 2023-12 |
| Fearless Foundation | Community improvement and capacity building | 501(c)(3) | 2015 | $8,303 | $61,703 | 2025-12 |
| 29-90 Sportsmans Club | Environment | 501(c)(3) | 2001 | $7,582 | $25,939 | 2025-12 |
| Jrotc Leadership Advantage | Education | 501(c)(3) | 2017 | $7,121 | $20,828 | 2025-12 |
| Amhara Community in Sioux Falls SD USA | Arts, culture and humanities | 501(c)(3) | 2022 | $7,035 | $9,910 | 2025-12 |
| Crosswalk Plaza Inc | Community improvement and capacity building | 501(c)(2) | 2017 | $3,960 | $3.9 million | 2023-12 |
| Lutheran Congregational Support Network | Religion-related | 501(c)(3) | 2024 | $1,659 | $104,815 | 2025-12 |
| Wonder Capes Inc | Medical research | 501(c)(3) | 2016 | $591 | $1 | 2025-12 |
| Aanenson Family Foundation | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 2023 | $181 | $29,699 | 2025-12 |
| 2G Charitable Foundation | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 2001 | $62,597 | 2025-12 | |
| 605 Boxer Rescue Inc | Animal-related | 501(c)(3) | 2019 | $0 | $0 | 2025-12 |
| 605 Dirt Divas Softball Association | Arts, culture and humanities | 501(c)(3) | 2025 | $8,100 | 2025-12 | |
| A & B Winstrom Christian Family Foundation | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 2009 | $5.8 million | 2025-12 | |
| A Coe & Dorothy Frankhauser Trust Uw 08-21-95 31-4111-00-6 | 501(c)(92) | $1.3 million | 2025-12 | |||
| A Cure for Cora | Medical research | 501(c)(3) | 2024 | $0 | $0 | 2025-12 |
| A Hand 2 Hold Inc | Human services | 501(c)(3) | 2024 | $0 | $0 | 2025-12 |
| A Man and His Bones | Education | 501(c)(3) | 2024 | $0 | $0 | 2025-12 |
| A R Wood Educational Trust | 501(c)(3) | 1966 | $113,379 | 2025-12 | ||
| A Voice for Children and Families | Human services | 501(c)(3) | 2008 | $0 | $0 | 2025-12 |
| Abate of Sioux Falls Inc | Public safety, disaster preparedness and relief | 501(c)(4) | 2009 | $0 | $0 | 2025-12 |
| Abate of South Dakota Foundation | Public safety, disaster preparedness and relief | 501(c)(3) | 2008 | $0 | $0 | 2025-12 |
| Abc of the Dakotas | 501(c)(3) | 1955 | 2011-12 | |||
| Abiding Savior Academy | Education | 501(c)(3) | 2025 | $0 | $0 | 2025-12 |
| Abiding Savior Free Lutheran Church | Religion-related | 501(c)(3) | 1972 | |||
| Abundant Life Church Inc | 501(c)(3) | 1984 | ||||
| Access To the Arts | Education | 501(c)(3) | 2024 | $8,640 | 2025-12 | |
| Acton Academy Sioux Falls | Education | 501(c)(3) | 2026 | |||
| Adventure Elementary Pto | Education | 501(c)(3) | 2026 | $0 | $0 | 2025-12 |
| Aequitas Health | Education | 501(c)(3) | 2021 | $0 | $0 | 2026-06 |
| African Wesleyan Church of Sioux Falls | 501(c)(3) | 1970 | ||||
| Africans Unite for Progress | Public and societal benefit | 501(c)(3) | 2022 | $0 | $0 | 2024-12 |
| Agape United Foundation | Human services | 501(c)(3) | 2017 | $0 | $0 | 2024-12 |
| Agents of the Trinity | Religion-related | 501(c)(3) | 2026 | |||
| Aglow International | 501(c)(3) | 1973 | $0 | $0 | 2025-12 | |
| Air Force Association | Education | 501(c)(3) | 2009 | $0 | $0 | 2025-12 |
| Air Guard Branch Camp Rapid Open Mess Joe Foss Field BLDG 31 | 501(c)(7) | 1977 | 2023-12 | |||
| Air Guard Federal Credit Union | 501(c)(1) | 2012-12 | ||||
| Alex Kummer Foundation | Mental health and crisis intervention | 501(c)(3) | 2024 | $0 | $0 | 2025-12 |
| All City Pto | Education | 501(c)(3) | 2014 | $0 | $0 | 2024-12 |
| All Nations City Church of Sioux Falls | Religion-related | 501(c)(3) | 2009 | |||
| All Saints Neighborhood Association | Community improvement and capacity building | 501(c)(3) | 2016 | $0 | $0 | 2025-12 |
| Alleviate Mental Health Fund | Health care | 501(c)(3) | 2024 | |||
| Alma Latina Grupo Cultural | Arts, culture and humanities | 501(c)(3) | 2025 | $0 | $0 | 2025-12 |
| Alpha Delta Kappa Sorority Inc | 501(c)(7) | 1970 | $0 | $0 | 2026-05 | |
| Alpine Cares | Community improvement and capacity building | 501(c)(3) | 2022 | $92,409 | 2025-12 |
By cause in Sioux Falls, SD
- Religion-related 126
- Education 108
- Philanthropy, voluntarism and grantmaking foundations 104
- Human services 98
- Recreation and sports 85
- Arts, culture and humanities 72
- Community improvement and capacity building 64
- Health care 63
- Public and societal benefit 28
- Youth development 25
- Food, agriculture and nutrition 19
- Mental health and crisis intervention 19
- Housing and shelter 17
- Animal-related 17
- Diseases, disorders and medical disciplines 16
- Environment 15
- Crime and legal-related 14
- Mutual and membership benefit 12
- International, foreign affairs and national security 12
- Civil rights, social action and advocacy 11
- Employment 8
- Medical research 8
- Public safety, disaster preparedness and relief 6
- Science and technology 3
Nonprofits in every city of the state
Read from the IRS Exempt Organizations Business Master File, updated by the IRS on October 24, 2026 and rebuilt here every morning. Revenue and assets are from each organization's latest filing as the IRS lists it; the IRS record is the official one. Organizations only: no people are named on these pages.