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Data / Nonprofits / South Dakota / Health care

Health care nonprofits in South Dakota: 214 registered with the IRS

214 health care nonprofits are registered with the IRS in South Dakota, 207 of them 501(c)(3) charities; the 115 that report revenue took in $5.50 billion. The most are in Sioux Falls (63), Rapid City (18), Watertown (8). The largest by revenue: Avera McKennan ($1.86 billion), Monument Health Rapid City Hospital Inc ($1.09 billion), Avera Health ($359.1 million).

SpecStream is the live web data engine for teams and agents. It reads the IRS register of exempt organizations as the IRS updates it, and this page is that reading. Ask for the nonprofits you need by place, cause and size, with their latest Form 990 figures and websites, and they arrive in your sheet, CRM, Slack or agent.

Every organization, largest by revenue first

OrganizationCityTypeSinceRevenueAssetsFiling
Avera McKennanSioux Falls501(c)(3)1942$1.86 billion$2.09 billion2025-06
Monument Health Rapid City Hospital IncRapid City501(c)(3)1974$1.09 billion$1.48 billion2025-06
Avera HealthSioux Falls501(c)(3)1993$359.1 million$2.58 billion2025-06
Avera Health Plans IncSioux Falls501(c)(4)2016$307.1 million$97.1 million2024-12
Monument Health Network IncRapid City501(c)(3)1981$221.1 million$180.6 million2025-06
Prairie Lakes Health Care System IncWatertown501(c)(3)1987$202.9 million$461.7 million2025-05
Avera St LukesAberdeen501(c)(3)1943$194.4 million$153.2 million2025-06
Sacred Heart Health ServicesYankton501(c)(3)1946$182.2 million$475.8 million2025-06
Avera Queen of PeaceMitchell501(c)(3)1946$159.9 million$223.1 million2025-06
Avera St MarysPierre501(c)(3)1946$133.9 million$101.1 million2025-06
Avera at HomeSioux Falls501(c)(3)1992$88.2 million$72.8 million2025-06
Huron Regional Medical Center IncHuron501(c)(3)1978$57.2 million$112 million2025-06
Madison Community HospitalMadison501(c)(3)1937$38 million$59.7 million2025-06
St Benedict Health CenterParkston501(c)(3)1946$37.6 million$107.3 million2025-06
SanfordSioux Falls501(c)(3)2011$35.2 million$792.7 million2024-12
Horizon Health Care IncHoward501(c)(3)1978$34.3 million$25.7 million2024-12
Mobridge Regional HospitalMobridge501(c)(3)1959$33.7 million$68.1 million2025-09
Fall River Health ServicesHot Springs501(c)(3)1999$33.1 million$40.8 million2024-12
Hegg Memorial HospitalSioux Falls501(c)(3)1973$30.4 million$60.4 million2025-06
Winner Regional Healthcare CenterWinner501(c)(3)1961$27.9 million$27.6 million2024-12
Coteau Des Prairies HospitalSisseton501(c)(3)1967$23.9 million$22.3 million2024-12
Platte Community Memorial Hospital IncPlatte501(c)(3)1958$22.7 million$40 million2025-06
Lifescape FoundationSioux Falls501(c)(3)1979$22.6 million$155.2 million2025-06
Wagner Community Memorial HospitalWagner501(c)(3)1959$22.5 million$24.4 million2025-06
Bethany Lutheran HomeSioux Falls501(c)(3)1952$19.9 million$31.4 million2025-06
Freeman Regional Health ServicesFreeman501(c)(3)1966$19.4 million$25.7 million2024-12
Philip Health Services IncPhilip501(c)(3)1981$18.5 million$25.3 million2025-12
F-M Ambulance Service IncSioux Falls501(c)(4)2003$17.7 million$9.8 million2024-12
Avera GettysburgGettysburg501(c)(3)1979$16.6 million$47.1 million2025-06
Pioneer Memorial Hospital & Health ServicesViborg501(c)(3)1952$14.2 million$21.2 million2024-12
Marshall County Memorial HospitalBritton501(c)(3)1984$13.2 million$18 million2025-06
Faulkton Area Medical CenterFaulkton501(c)(3)1984$13 million$13.2 million2025-12
Douglas County Memorial HospitalArmour501(c)(3)1988$12.7 million$19.3 million2025-05
Bennett County Hospital and Nursing HomeMartin501(c)(3)2006$12.6 million$9.2 million2024-12
Sanford Health Foundation NorthSioux Falls501(c)(3)1988$10.9 million$107.3 million2024-12
South Dakota Lions Eye and Tissue Bank IncSioux Falls501(c)(3)1992$9.5 million$12.3 million2025-06
Landmann Jungman Memorial Hospital CorporationScotland501(c)(3)1964$7.5 million$5.3 million2025-06
Sunset Manor IncIrene501(c)(3)1964$7.2 million$5 million2024-12
Eureka Community & Benevolent HospitalEureka501(c)(3)1932$6.2 million$10.9 million2025-06
LifescapeSioux Falls501(c)(3)2015$6.1 million$692,6252025-06
Weskota Manor IncWessingtn SPG501(c)(3)1966$5 million$3.1 million2025-12
Brookings Health System Investment AuthorityBrookings501(c)(3)2019$4.8 million$81.9 million2025-12
Sanford Health Foundation WestSioux Falls501(c)(3)1987$4.7 million$35.1 million2024-12
Walworth County Care Center IncSelby501(c)(3)2023$4.5 million$4 million2024-12
Community Healthcare Association of the DakotasSioux Falls501(c)(3)1985$4.3 million$1.2 million2025-06
South Dakota Foundation for Medical CareSioux Falls501(c)(3)1974$3.8 million$2 million2024-12
Endeavor HealthBox Elder501(c)(3)1993$3.6 million$3.8 million2024-09
Delta Dental of South Dakota FoundationPierre501(c)(3)1998$3.4 million$9.6 million2025-12
Wilmot Care CenterWilmot501(c)(3)2001$3.3 million$3.1 million2025-06
Huron Clinic Foundation IncHuron501(c)(3)1947$3.3 million$3.8 million2025-12
Kadoka Nursing Home AssociationKadoka501(c)(3)1950$3 million$1.8 million2024-12
Strand-Kjorsvig Community Rest HomeRoslyn501(c)(3)1959$2.8 million$1.4 million2025-08
Monument Health IncRapid City501(c)(3)2006$2.6 million$22,9342025-06
Black Hills Center for American Indian HealthRapid City501(c)(3)1999$2.2 million$538,1642024-12
Heartland Health Resource CenterSioux Falls501(c)(3)2013$1.8 million$1.2 million2025-06
Spearfish Emergency Ambulance ServiceSpearfish501(c)(3)1977$1.8 million$783,5902024-12
Sanford Health Foundation of Northern MinnesotaSioux Falls501(c)(3)1981$1.6 million$10.2 million2024-12
Hand County Memorial HospitalMiller501(c)(3)1986$1.3 million$5.6 million2025-06
Black Hills Health and Education CenterHermosa501(c)(3)1980$1.2 million$1.3 million2025-12
Custer Ambulance Service IncCuster501(c)(3)$1 million$1.5 million2024-12
Tower Industry Family Support Charitable FoundationWatertown501(c)(3)2014$988,535$6.5 million2025-12
Huron Ambulance Service IncHuron501(c)(3)1971$844,896$1.7 million2025-02
Prairie Lakes Health Care FoundationWatertown501(c)(3)1980$816,715$5.4 million2024-12
West River Area Health Education CenterBox Elder501(c)(3)2020$732,967$196,1072025-06
Fund for Advancement of Medical Education and ResearchSioux Falls501(c)(3)1986$668,045$4.5 million2025-06
HRMC FoundationHuron501(c)(3)1995$588,370$3.9 million2024-12
Dell Rapids Community Ambulance ServiceDell Rapids501(c)(3)2025$583,709$656,9282024-12
Piedmont Emergency Medical Services IncPiedmont501(c)(3)2025$530,526$390,7682025-12
Missouri Valley Ambulance Joint Powers BoardChamberlain501(c)(3)1998$508,680$634,9002024-12
Keystone Ambulance Service IncKeystone501(c)(3)1997$494,200$178,2022024-12
Prairie Heart Guest House IncSioux Falls501(c)(3)2002$443,557$2 million2024-12
Black Hills Crisis Pregnancy CenterRapid City501(c)(3)2017$405,547$300,5252024-12
Bella Pregnancy Resource CenterSpearfish501(c)(3)1987$386,442$836,6712024-12
S P U R S Therapeutic Riding Center IncAberdeen501(c)(3)1992$385,694$1.1 million2025-12
Brookings Health System FoundationBrookings501(c)(3)2010$358,898$1.3 million2025-12
Yankton Rural Area Health Education CenterYankton501(c)(3)2000$336,621$133,2302025-08
Teddy Bear DenSioux Falls501(c)(3)2002$331,949$760,3572024-12
Philip Ambulance ServicePhilip501(c)(3)2019$331,750$1.1 million2025-12
Madison Community Hospital Foundation IncMadison501(c)(3)2014$317,492$1.5 million2025-06
Zoecare IncYankton501(c)(3)2020$314,234$194,6902024-12
Midwest Street MedicineSioux Falls501(c)(3)2023$308,652$173,7832025-06
Garretson Community Ambulance CorporationGarretson501(c)(3)1996$290,999$192,2962025-12
Deuel County Ambulance IncClear Lake501(c)(3)2023$282,285$627,8182025-12
Growing Up TogetherPierre501(c)(3)1992$233,422$121,1542025-06
Bethel Lutheran Home Foundation IncMadison501(c)(3)1990$220,885$1.7 million2024-06
South Dakota Dental FoundationPierre501(c)(3)2018$215,146$329,2952025-12
South Dakota Trauma Education IncSioux Falls501(c)(3)2005$176,354$77,3202025-12
Platte Ambulance ServicePlatte501(c)(3)2014$162,764$542,8082025-12
Lemmon Emt AssociationLemmon501(c)(3)1995$155,793$359,4242022-12
Immunize South DakotaSioux Falls501(c)(3)2021$153,955$32,9632024-12
Good Shepherd Clinic IncSpearfish501(c)(3)2009$118,088$326,4762025-12
Rare By Design IncSioux Falls501(c)(3)2021$111,998$142,3052025-12
Burke Ambulance Service IncBurke501(c)(3)2023$110,200$426,4632025-12
Alcester EmsAlcester501(c)(3)2023$102,408$163,2532025-12
Bowdle Health Care FoundationBowdle501(c)(3)2004$96,571$631,8842025-12
Gettysburg Ambulance Gang IncGettysburg501(c)(3)2024$96,169$371,2962025-12
National Abstinence Clearing HouseSioux Falls501(c)(3)1998$95,980$19,2882024-12
Foundation for HealthDeadwood501(c)(3)1988$83,444$1 million2025-06
Community Ambulance ServiceMarion501(c)(3)2012$76,651$412,8642024-12
Heart and Sole Cancer Assistance IncMitchell501(c)(3)1999$70,393$96,8412024-12
Bryant Area Improvement IncBryant501(c)(3)2004$66,616$325,8192024-12
Supporters for the Hill City AmbulanceHill City501(c)(3)2023$66,552$65,7552025-12
Live Inspired 365 IncSioux Falls501(c)(3)2023$65,823$144,2432024-12
Coteau Des Prairies Hospital & Clinic FoundationSisseton501(c)(3)2009$63,901$338,6032025-12
St Francis Mission Dental ClinicSaint Francis501(c)(3)2011$63,394$68,9242025-06
Search & Rescue Support IncWatertown501(c)(3)2006$62,114$283,6022024-12
Spirit Canyon Apartments IncSioux Falls501(c)(3)1978$60,109$61,9022024-12
Servant Hearts Clinic IncYankton501(c)(3)2012$55,279$147,5632025-12
Faulkton Area Medical Center Foundation IncFaulkton501(c)(3)2018$54,589$605,7472024-12
Pioneer Memorial FoundationViborg501(c)(3)2008$51,683$577,9462024-12
Douglas County Memorial Hospital FoundationArmour501(c)(3)2014$51,246$1.4 million2025-12
Hands of Hope IncMiller501(c)(3)2015$49,899$120,9422024-12
Freedom Dental Anesthesia CenterSioux Falls501(c)(3)2024$40,658$22,0422025-12
Dells Area Health CenterDell Rapids501(c)(3)1960$23,642$2.5 million2025-08
Cosmopolitan Fund for ChildrenSioux Falls501(c)(3)1997$23,558$310,6792025-06
1917 FoundationBrandon501(c)(3)2025
Alcester Health Services Foundation IncAlcester501(c)(3)1978$0$02025-12
Alleviate Mental Health FundSioux Falls501(c)(3)2024
Alzheimers Centers of AmericaRapid City501(c)(3)2023$0$02025-12
AsniyaRapid City501(c)(3)2005$0$02025-06
Assisting Children To Smile IncWatertown501(c)(3)2024$0$02025-09
Association of Active Emergency Medical Technicians of Clay CountyVermillion501(c)(3)2015$0$02025-12
Beadle County Ems IncHuron501(c)(3)2026
Birthright of PierrePierre501(c)(3)2013$0$02025-12
Cancer Healing Assitance Resource TeamMartin501(c)(3)2019$0$02025-12
Carroll Institute FoundationSioux Falls501(c)(3)1995$0$02026-06
Changing Lives FoundationRapid City501(c)(3)2021$0$02025-12
Clark Ems AssociationClark501(c)(3)2026
Community Health Worker Collaborative of South DakotaSioux Falls501(c)(3)2024$0$02024-12
Community Health and Development IncHot Springs501(c)(3)2002$0$02025-12
Community Services Connection of the Black HillsRapid City501(c)(3)2003$0$02025-12
Deaf Bikers of America Foundation IncSioux Falls501(c)(3)2017$0$02025-12
Equine Rehabilitation Project IncHarrisburg501(c)(3)2013$0$02024-12
Fabulous MomentsDell Rapids501(c)(3)2018$0$02025-12
Families Finding JoySioux Falls501(c)(3)2024$11,6182025-12
Faulkton Ambulance CrewFaulkton501(c)(3)2021$0$02025-12
First District Medical SocietyAberdeen501(c)(3)2014$4,8572025-12
Fishing for A Cure IncChamberlain501(c)(3)2018$0$02025-12
Glacial Lakes Ems FoundationWebster501(c)(3)2026
Glacier Care Center IncSpearfish501(c)(3)2005$0$02025-12
Good Samaritan-Sanford Community Health ServicesSioux Falls501(c)(3)1999
Greater Sturgis Lifecare FoundationSturgis501(c)(3)2004$0$02025-06
H & H International Medical Specialty Education FoundationSioux Falls501(c)(3)2025$0$02025-12
H&M Services IncRapid City501(c)(3)2011$0$02024-12
Help 4 HuhasSioux Falls501(c)(3)2019$0$02024-12
Humboldt Pink LadiesHumboldt501(c)(3)2023$0$02025-12
Kendalls CourageRapid City501(c)(3)2021$0$02023-12
Kids Cancer PT CommunicationsSioux Falls501(c)(3)2025$0$02025-12
Kingsbury Cancer Care IncLake Preston501(c)(3)2012$0$02025-12
Lachs LegacySummerset501(c)(3)2017$0$02025-12
Lake Area Kidney EndowmentWatertown501(c)(3)2015$0$02025-12
Lantis Resident Council IncSpearfish501(c)(3)1995$0$02025-12
Lennox Jack Lapsley FoundationWinner501(c)(3)2024$0$02023-12
Libertys TroopsFlandreau501(c)(3)2014$0$02024-12
Marshall County Wow Coalition IncBritton501(c)(3)2018$0$02025-12
Missouri Valley Foundation for Health CareYankton501(c)(3)1998$0$02026-06
Monument Health Physicians IncRapid City501(c)(3)1984$12025-06
Palace City Pedalers Tour de Corn IncMitchell501(c)(3)2012$0$02025-12
Philip Area Health FoundationPhilip501(c)(3)2021$0$02025-12
Pink Ladies Dart LeagueMilbank501(c)(3)2023$0$02025-12
Post 36 FitnessBonesteel501(c)(3)2018$0$02023-12
Prairie Lakes Legacy Fund IncWatertown501(c)(3)2026$13.9 million2025-12
Real Life Farming IncSioux Falls501(c)(3)2020$0$02025-12
Rocke Grace Foundation for Music and Medicine IncRapid City501(c)(3)2023$0$02024-12
Rosholt First RespondersRosholt501(c)(3)2024$0$02025-12
Rural Meade Ambulance ServiceEnning501(c)(3)1997$0$02025-12
SanfordSioux Falls501(c)(3)20012024-12
SanfordSioux Falls501(c)(3)20112007-04
SanfordSioux Falls501(c)(3)20112024-12
SanfordSioux Falls501(c)(3)20112024-12
SanfordSioux Falls501(c)(3)20112024-12
SanfordSioux Falls501(c)(3)20112024-12
SanfordSioux Falls501(c)(3)20112011-12
SanfordSioux Falls501(c)(3)20112024-12
SanfordSioux Falls501(c)(3)20112024-12
SanfordSioux Falls501(c)(3)2011
SanfordSioux Falls501(c)(3)20112011-06
SanfordSioux Falls501(c)(3)20112023-12
SanfordSioux Falls501(c)(3)2011
Scope FoundationSioux Falls501(c)(3)2026
Siouxland Dental & Implant Study Club IncSioux Falls501(c)(3)2014$0$02024-12
Sonny Way FoundationHuron501(c)(3)2026
South Dakota Allergy SocietySioux Falls501(c)(3)2012$0$02025-12
South Dakota Ambulance AssociationSpearfish501(c)(3)2016$0$02024-12
South Dakota Association of Healthcare QualitySioux Falls501(c)(3)2020$0$02025-12
South Dakota Chapter American College of Emergency PhysiciansRapid City501(c)(6)2024$0$02025-12
South Dakota Chapter of the American Academy of PediatricsSioux Falls501(c)(6)2000$0$02025-06
South Dakota Nurses Foundation IncNunda501(c)(3)2025$0$02025-06
South Dakota Organization of Nurse Leaders-SdonlYankton501(c)(6)2014$0$02023-12
South Dakota Perinatal Association IncSioux Falls501(c)(3)2000$0$02026-01
South Dakota Safe Childbirth OptionsSioux Falls501(c)(4)2005$0$02025-12
South Dakota School Nurse AssociationRapid City501(c)(3)2016$0$02025-08
Splitrock Clinic AssociationGarretson501(c)(3)2012$0$02025-09
Stevens High School Booster ClubRapid City501(c)(3)2022$0$02025-10
Strand-Kjorsvig FoundationRoslyn501(c)(3)2015$0$02025-08
Team HopeMilbank501(c)(3)2024$0$02025-12
Team of Angels FoundationFlandreau501(c)(3)2004$94,5842024-12
Tekakwitha Nursing HomeSisseton501(c)(3)1946
Therapeautic Healing InstituteSioux Falls501(c)(3)2005$0$02023-12
Therapy Dogs Sioux FallsSioux Falls501(c)(3)2026$0$02025-12
Thrivewell FoundationSioux Falls501(c)(3)2024$0$02024-12
Timber Lake Ambulance Service IncTimber Lake501(c)(3)2007$0$02025-12
Tops Club IncRapid City501(c)(3)2008$0$02026-03
Tops Club IncRapid City501(c)(3)2008$0$02026-03
Tops Club IncSioux Falls501(c)(3)2008$0$02026-03
Tops Club IncWatertown501(c)(3)2008$0$02025-03
Tops Club IncHartford501(c)(3)2008$0$02026-03
Wacante KiyapiPine Ridge501(c)(3)2018$22024-12
Wagner Area Health and Wellness ConsortiumWagner501(c)(4)2006$0$02025-10
Webster Area Pach ProgramWebster501(c)(3)2019$0$02025-12
Wesleyan Homes IncGettysburg501(c)(3)1970$0$02026-03
White Care Center IncBrookings501(c)(3)1985$0$02025-12
Winner Area Breast Cancer Foundation and Support GroupWinner501(c)(3)2017$0$02025-12
Wolsey Ems AssociationWolsey501(c)(3)2014$263,8122025-12

Every nonprofit in South Dakota

Read from the IRS Exempt Organizations Business Master File, updated by the IRS on October 24, 2026 and rebuilt here every morning. Revenue and assets are from each organization's latest filing as the IRS lists it; the IRS record is the official one. Organizations only: no people are named on these pages.