| Prisma Health Medical Group-Midlands | 501(c)(3) | 2014 | $401.1 million | $113.4 million | 2025-09 |
| Furman University | 501(c)(3) | 1937 | $296.9 million | $1.45 billion | 2025-06 |
| Bju Inc | 501(c)(3) | 2003 | $114.8 million | $108.7 million | 2025-05 |
| The Heron Institute | 501(c)(3) | 2017 | $49.9 million | $44.7 million | 2025-06 |
| Christ Church Episcopal School | 501(c)(3) | 2001 | $44.1 million | $76 million | 2025-06 |
| Global Renewable Energy Education Network | 501(c)(3) | 2013 | $35.9 million | $61.8 million | 2025-06 |
| Sunbelt Human Advancement Resources Inc | 501(c)(3) | 1966 | $34.4 million | $19.6 million | 2025-09 |
| Legacy Early College | 501(c)(3) | 2008 | $24.3 million | $17.7 million | 2025-06 |
| Building Equity Sooner for Tomarrow | 501(c)(3) | 2006 | $14.2 million | $294.4 million | 2025-06 |
| First Presbyterian Academy Inc | 501(c)(3) | 2019 | $7.4 million | $10 million | 2025-06 |
| Greenville Technical Charter High School | 501(c)(3) | 1999 | $7.1 million | $9.6 million | 2025-06 |
| Lead Academy | 501(c)(3) | 2009 | $6 million | $16.7 million | 2025-06 |
| Camperdown Academy Inc | 501(c)(3) | 1987 | $5.4 million | $12.7 million | 2025-06 |
| Langston Charter Middle School Inc | 501(c)(3) | 2006 | $5.2 million | $4.1 million | 2025-06 |
| Greenville Tech Foundation Inc | 501(c)(3) | 1974 | $5.1 million | $48.5 million | 2024-12 |
| University Center of Greenville Inc | 501(c)(3) | 2010 | $3.5 million | $3.9 million | 2025-06 |
| East Link Academy | 501(c)(3) | 2018 | $3.2 million | $1.1 million | 2025-06 |
| Veritas Preparatory School Inc | 501(c)(3) | 2014 | $3 million | $1.4 million | 2025-06 |
| National Christian College Athletic Association | 501(c)(3) | 1985 | $2.5 million | $3.5 million | 2025-12 |
| Center for Courage & Renewal | 501(c)(3) | 2003 | $2.2 million | $2.6 million | 2025-06 |
| Furman University Foundation Inc | 501(c)(3) | 2016 | $1.8 million | $22.9 million | 2025-06 |
| Chandler School | 501(c)(3) | 2020 | $1.5 million | $3 million | 2025-06 |
| Upstate Father Hood Coalition | 501(c)(3) | 2004 | $1.2 million | $1.3 million | 2025-09 |
| Peru Mission USA Inc | 501(c)(3) | 2004 | $1.1 million | $550,105 | 2025-09 |
| CP Now | 501(c)(3) | 2015 | $1.1 million | $746,525 | 2024-12 |
| Carolina International Preparatory School | 501(c)(3) | 2011 | $1 million | $1.6 million | 2025-06 |
| Kings Classical School | 501(c)(3) | 2025 | $1 million | $961,091 | 2025-06 |
| Greenville Literacy Association Inc | 501(c)(3) | 1974 | $913,934 | $1.7 million | 2025-06 |
| Public Education Partners | 501(c)(3) | 1985 | $781,387 | $1.6 million | 2025-06 |
| Poe Mill Achievement Center | 501(c)(3) | 2018 | $744,901 | $978,867 | 2025-12 |
| BC Corp | 501(c)(3) | 2019 | $740,538 | $86,568 | 2024-12 |
| Compass of Carolina Inc | 501(c)(3) | 1964 | $684,418 | $3.8 million | 2024-12 |
| Bel-Aire Community Partners | 501(c)(3) | 2020 | $641,036 | $560,569 | 2025-12 |
| Legacy Advancement | 501(c)(3) | 2015 | $608,039 | $2.5 million | 2024-12 |
| Feed & Seed Co | 501(c)(3) | 2016 | $599,669 | $2.3 million | 2024-12 |
| Flourish Adoption Ministries Inc | 501(c)(3) | 2017 | $586,153 | $197,375 | 2025-12 |
| Greenville High Red Raider Sports Booster Club Inc | 501(c)(3) | 2005 | $556,496 | $233,651 | 2025-06 |
| Dream Preparatory Academy Inc | 501(c)(3) | 2023 | $534,731 | $33,758 | 2025-12 |
| Langston Foundation Inc | 501(c)(3) | 2009 | $506,995 | $4.2 million | 2025-06 |
| Uu World of Children | 501(c)(3) | 2007 | $503,903 | $902,048 | 2025-06 |
| J L Mann Athletic Booster Club Inc | 501(c)(3) | 1999 | $454,376 | $407,960 | 2025-06 |
| Greenville Woodworkers Guild Incorporated | 501(c)(3) | 2004 | $400,495 | $2.1 million | 2025-08 |
| Christian Learning Centers of Greenville County | 501(c)(3) | 1998 | $395,229 | $159,217 | 2024-06 |
| Greenville Country Club Scholarship Foundation | 501(c)(3) | 2022 | $366,499 | $600,302 | 2025-12 |
| South Carolina Athletic Administrators Association | 501(c)(4) | 2005 | $258,664 | $274,815 | 2025-12 |
| Harold C Jennings Foundation | 501(c)(3) | 1977 | $244,763 | $1.8 million | 2025-12 |
| Best Skills Academy | 501(c)(3) | 2019 | $244,315 | $180,825 | 2025-12 |
| Our Saviour Community Ministries | 501(c)(3) | 2015 | $236,826 | $314,755 | 2025-06 |
| Charis Language Immersion Academy | 501(c)(3) | 2023 | $199,376 | $47,613 | 2025-12 |
| Kind of the Upstate | 501(c)(3) | 2021 | $163,435 | $143,929 | 2025-12 |
| Roots and Wings Nature School | 501(c)(3) | 2024 | $156,374 | $40,382 | 2025-12 |
| Echoes of Emma Inc | 501(c)(3) | 2023 | $117,531 | $120,845 | 2025-12 |
| Powdersville High School Athletic Booster Club Inc | 501(c)(3) | 2011 | $112,674 | $52,331 | 2025-07 |
| Greenville County Schools Foundation | 501(c)(3) | 2014 | $112,065 | $181,481 | 2024-12 |
| Systematic Tutoring Resulting in Development of Essential Skills | 501(c)(3) | 2005 | $90,082 | $49,542 | 2025-12 |
| Parent Booster USA Inc | 501(c)(3) | 2005 | $88,138 | $14,709 | 2026-05 |
| Asociacion Hispano Americana de Mujeres | 501(c)(3) | 2000 | $71,853 | $177,369 | 2025-12 |
| Einstein Learning Center Inc | 501(c)(3) | 2007 | $61,024 | $84,867 | 2025-08 |
| Center for Educational Equity | 501(c)(3) | 2001 | $58,825 | $196,906 | 2025-12 |
| South Carolina Congress of Parents and Teachers | 501(c)(3) | 1979 | $49,656 | $37,351 | 2025-06 |
| Powdersville Elementary Ptso | 501(c)(3) | 2022 | $44,507 | $64,984 | 2025-07 |
| Rice Vinskus Scholarship | 501(c)(3) | 2009 | $37,078 | $77,586 | 2025-12 |
| Wade Hampton Football Booster Club | 501(c)(3) | 2020 | $37,016 | $29,023 | 2025-12 |
| Church Street Choral Academy | 501(c)(3) | 2024 | $29,118 | $38,353 | 2025-12 |
| Sterling High School Alumni Association | 501(c)(3) | 2024 | $25,647 | $188,405 | 2025-12 |
| South Carolina Military Scholarship & Family Care Association Inc | 501(c)(3) | 2003 | $12,695 | $318,370 | 2024-12 |
| Powdersville Middle School Ptso | 501(c)(3) | 2012 | $7,547 | $15,372 | 2025-07 |
| Blue Ridge Orchid Society of South Carolina | 501(c)(3) | 1997 | $2,980 | $10,239 | 2026-06 |
| 500 Foundation Inc | 501(c)(3) | 2024 | $500 | $500 | 2024-12 |
| Ace Mentor Program of the Upstate I NC | 501(c)(3) | 2026 | | | |
| Adult Summer Music Camp | 501(c)(3) | 2026 | | | |
| Adulting 101 Org | 501(c)(3) | 2020 | $0 | $0 | 2025-12 |
| American Inns of Court Foundation | 501(c)(3) | 2024 | $0 | $0 | 2025-06 |
| Arete Group Inc | 501(c)(3) | 2023 | $0 | $0 | 2025-12 |
| Asher Mills Memorial | 501(c)(3) | 2017 | $0 | $0 | 2025-12 |
| Association of War Zone Contractors | 501(c)(3) | 2025 | | | |
| Berea Early College | 501(c)(3) | 2021 | $0 | $0 | 2026-06 |
| Bju Scholarship Fund | 501(c)(3) | 2005 | $0 | $0 | 2025-05 |
| Bridge Corporation | 501(c)(3) | 2005 | $0 | $0 | 2026-02 |
| Bruins Foundation | 501(c)(3) | 2013 | $0 | $0 | 2025-12 |
| Bubba and Bleeker Cannon Student-Athlete Scholarship | 501(c)(3) | 2020 | $0 | $0 | 2025-12 |
| Building A Better Tomorrow Global Foundation | 501(c)(3) | 2026 | | | |
| Cannabis Forward | 501(c)(3) | 2016 | $0 | $0 | 2025-12 |
| Carlo and Nika White Foundation | 501(c)(3) | 2019 | | $95,399 | 2025-12 |
| Carolina Literacy Project Inc | 501(c)(3) | 2022 | $0 | $0 | 2025-12 |
| Carolina Marsh Tacky Association | 501(c)(3) | 2014 | $0 | $0 | 2025-12 |
| Carolina Prep Scholarship Foundation | 501(c)(3) | 2015 | $0 | $0 | 2025-06 |
| Champion for Christ Foundation Inc | 501(c)(3) | 1997 | | $2.4 million | 2025-12 |
| Chapman Foundation | 501(c)(3) | 2004 | | $2.8 million | 2025-12 |
| Clemson Elementary School Tigerfund | 501(c)(3) | 2007 | $0 | $0 | 2025-06 |
| Colin Christopher Kittrell Scholarship Foundation | 501(c)(3) | 2023 | $0 | $0 | 2025-12 |
| Community and Family Network | 501(c)(3) | 2023 | $0 | $0 | 2025-12 |
| Creative Intelligence Associates | 501(c)(3) | 2026 | | | |
| Dawn Retreat Center | 501(c)(3) | 2021 | $0 | $0 | 2025-12 |
| Foothills Piecemakers Quilting Guild Inc | 501(c)(3) | 1994 | $0 | $0 | 2026-06 |
| Foundation for Academic Excellence | 501(c)(3) | 2011 | $0 | $0 | 2026-06 |
| Founder Education Scholarships | 501(c)(3) | 2026 | | | |
| Friends in Responder Education | 501(c)(3) | 2024 | $0 | $0 | 2025-06 |
| Georgia Kids First Scholarship Program Inc | 501(c)(3) | 2020 | $0 | $0 | 2025-06 |
| Global Autonomous Vehicle Partnership | 501(c)(3) | 2016 | $0 | $0 | 2024-12 |
| Green Charter School of Greenville Parent Volunteer Organization | 501(c)(3) | 2019 | $0 | $0 | 2024-06 |
| Green Charter Simpsonville Pto | 501(c)(3) | 2024 | | | |
| Greenville Forward | 501(c)(3) | 2006 | $0 | $0 | 2025-06 |
| Greenville High School Band Booster Club | 501(c)(3) | 2014 | $0 | $0 | 2026-05 |
| Grove Collective | 501(c)(3) | 2024 | $0 | $0 | 2026-06 |
| Hampton University | 501(c)(3) | 1994 | $0 | $0 | 2025-06 |
| Hope for the Home Inc | 501(c)(3) | 1997 | $0 | $0 | 2023-12 |
| Ians Orbit Foundation | 501(c)(3) | 2025 | | | |
| Iota Nu Chapter Sigma Chi Fraternity | 501(c)(7) | 2019 | $0 | $0 | 2025-12 |
| Ivybrook Academy Greenville Pto | 501(c)(3) | 2026 | $0 | $0 | 2025-12 |
| Keep Greenville County Beautiful | 501(c)(3) | 2011 | $0 | $0 | 2025-12 |
| Kingdom Learning School of Excellence | 501(c)(3) | 2021 | $0 | $0 | 2026-06 |
| Kiss Foundation | 501(c)(3) | 2020 | $0 | $0 | 2023-12 |
| Las Amigas Inc Greenville Chapter | 501(c)(3) | 2019 | $0 | $0 | 2025-12 |
| Leading the Way Academy Foundation | 501(c)(3) | 2026 | | | |
| MRS Donnetta H Martin Memorial Fund Service and Scholarship | 501(c)(3) | 2012 | $0 | $0 | 2025-12 |
| Memories in Writing Foundation Inc | 501(c)(3) | 2024 | | | |
| Mother of Pearl Inc | 501(c)(3) | 2004 | $0 | $0 | 2024-12 |
| National Advisory Board for Motorsports Education | 501(c)(3) | 2026 | | | |
| National Association of Teachers of Singing Inc | 501(c)(3) | 2009 | $0 | $0 | 2025-12 |
| Omega Limited Scholarship Foundation of Greenville SC | 501(c)(3) | 2015 | $0 | $0 | 2025-12 |
| Operation English | 501(c)(3) | 2023 | $0 | $1 | 2025-12 |
| Palmetto Chapter - Us Naval Academy Alumni Association Inc | 501(c)(3) | 2018 | $0 | $0 | 2025-12 |
| Palmetto Financial Freedom Initiative Inc | 501(c)(3) | 2025 | $0 | $0 | 2025-12 |
| Parent Booster USA Inc | 501(c)(3) | 2005 | $0 | $0 | 2025-06 |
| Parent Booster USA Inc | 501(c)(3) | 2005 | $0 | $0 | 2025-06 |
| Parent Teacher Organization of Green Charter Elementary School GR | 501(c)(3) | 2023 | $0 | $0 | 2025-06 |
| Parent Teachers Association | 501(c)(3) | 2024 | $0 | $0 | 2026-06 |
| Partners in Literacy Haiti | 501(c)(3) | 2021 | $0 | $0 | 2025-12 |
| Patricia -Nurse Pat- Edwards Nursing Scholarship | 501(c)(3) | 2024 | $0 | $0 | 2025-12 |
| Peabody Foundation | 501(c)(3) | 1998 | | $353,831 | 2024-12 |
| Penn State Alumni Association | 501(c)(3) | 2001 | $0 | $0 | 2026-06 |
| Pericles Lenardis Scholarship Fund | 501(c)(3) | 2026 | | | |
| Phi Eta Sigma National Honor Society Inc | 501(c)(3) | 2014 | | | |
| Piedmont Home Educators Association Inc | 501(c)(3) | 2019 | $0 | $0 | 2026-07 |
| Provence Foundation | 501(c)(3) | 1996 | | $150,099 | 2025-11 |
| Pta South Carolina Congress | 501(c)(3) | 2026 | | | |
| Pta South Carolina Congress Cherrydale Elementary | 501(c)(3) | 2024 | $0 | $0 | 2026-06 |
| Purple Garage | 501(c)(3) | 2025 | $0 | $0 | 2025-12 |
| Pursue Cyber | 501(c)(3) | 2026 | | | |
| Reaching Our Youth Upstate | 501(c)(3) | 2016 | $0 | $0 | 2024-12 |
| Rejuvenating Lives | 501(c)(3) | 2026 | $0 | $0 | 2021-12 |
| Restorative Scholars Initiative | 501(c)(3) | 2025 | $0 | $0 | 2025-12 |
| Rollin Readers Inc | 501(c)(3) | 2017 | $0 | $0 | 2025-12 |
| SC Section of Ite | 501(c)(3) | 2021 | $0 | $0 | 2025-12 |
| Sam Stitt Foundation | 501(c)(3) | 2022 | $0 | $0 | 2025-12 |
| Sarvam Trust USA Inc | 501(c)(3) | 2013 | $0 | $0 | 2025-12 |
| Short Strides Inc | 501(c)(3) | 2024 | $0 | $0 | 2025-12 |
| Social Evolution Inc | 501(c)(3) | 2017 | $0 | $0 | 2025-12 |
| South Carolina Congress of Parents and Teachers | 501(c)(3) | 1979 | $0 | $0 | 2026-06 |
| South Carolina Hispanic Chamber of Commerce Foundation | 501(c)(3) | 2011 | $0 | $0 | 2025-12 |
| South Carolina Phi Chapter of Sigma Alpha Epsilon Fraternity | 501(c)(7) | 2025 | $0 | $0 | 2025-12 |
| South Carolina State University National Alumni Association | 501(c)(3) | 2001 | $0 | $0 | 2026-05 |
| St Pauls Christian School | 501(c)(3) | 2000 | | | |
| Steam Junction | 501(c)(3) | 2024 | $0 | $0 | 2025-12 |
| Sterling Pride 72 | 501(c)(3) | 2022 | $0 | $0 | 2025-08 |
| Streams of Blessings | 501(c)(3) | 2025 | | | |
| Total Empowerment CDC | 501(c)(3) | 2009 | $0 | $0 | 2023-12 |
| Transformed Futures Education & Training | 501(c)(3) | 2024 | | | |
| Trauma Links Foundation | 501(c)(3) | 2025 | $0 | $0 | 2025-12 |
| United Patriots Alliance Inc | 501(c)(3) | 2024 | $0 | $0 | 2024-08 |
| Upstate Interfaith Coalition for African American Policy | 501(c)(3) | 2024 | | | |
| Voorhees University National Alumni Association | 501(c)(3) | 2025 | $0 | $0 | 2025-06 |
| Yolanda L Dillard Memorial Scholarship Fund | 501(c)(3) | 2023 | $0 | $0 | 2025-12 |
| Zeta Phi Beta Sorority | 501(c)(7) | 1960 | $0 | $0 | 2026-06 |
| Zeta Phi Beta Sorority Incorporated Epsilon Iota Zeta Chapter | 501(c)(7) | 2024 | | | |
| Next School | 501(c)(3) | 2015 | $-83,410 | $0 | 2023-06 |