| Columbia Empowerment Zone Inc | 501(c)(3) | 2008 | $5.4 million | $17.8 million | 2025-06 |
| Investsc Inc | 501(c)(3) | 2007 | $5 million | $22.5 million | 2025-12 |
| South Carolina Dealer Services LLC | 501(c)(6) | 2021 | $4.6 million | $3.8 million | 2025-06 |
| Columbia Facilities Corporation | 501(c)(3) | 2026 | $2.5 million | $90.7 million | 2025-06 |
| Original Six Foundation | 501(c)(3) | 2012 | $2.5 million | $2.3 million | 2025-06 |
| South Carolina Council On Competitiveness | 501(c)(3) | 2005 | $2.4 million | $3.3 million | 2025-06 |
| Beta Zeta House Corporation | 501(c)(2) | 2003 | $2.4 million | $7.5 million | 2025-12 |
| Central Carolina Economic Development Alliance | 501(c)(3) | 1996 | $2.4 million | $3.3 million | 2025-06 |
| City Center Partnership Inc | 501(c)(6) | 2001 | $2.1 million | $1.2 million | 2025-06 |
| SC Uplift Community Outreach | 501(c)(3) | 2008 | $1.7 million | $546,928 | 2024-12 |
| Lambda Theta House Corporation of Phi Mu Fraternity | 501(c)(2) | 2019 | $1.7 million | $3.2 million | 2025-06 |
| National Organization of Rheumatology Managers | 501(c)(6) | 2012 | $1.6 million | $3.3 million | 2025-12 |
| Business and Industry Coalition Inc and the S Carolina Civil Just Coal | 501(c)(6) | 2003 | $1.4 million | $626,333 | 2025-12 |
| SC Launch Inc | 501(c)(3) | 2008 | $1.1 million | $36.6 million | 2025-06 |
| Together SC | 501(c)(3) | 1998 | $993,073 | $405,477 | 2025-06 |
| Usc Columbia Technology Incubator | 501(c)(3) | 2012 | $946,846 | $340,947 | 2024-12 |
| Pink & Green Community Service Foundation | 501(c)(3) | 2014 | $903,979 | $694,330 | 2025-12 |
| South Carolina Pharmaceutical Association | 501(c)(6) | 2003 | $796,589 | $2.1 million | 2025-12 |
| Black Pages International | 501(c)(3) | 2004 | $796,394 | $29,407 | 2024-12 |
| Wine and Spirits Wholesalers Association of South Carolina | 501(c)(6) | 2012 | $762,714 | $158,718 | 2025-12 |
| Rho Chapter Kappa Alpha Housing Corporation | 501(c)(2) | 2000 | $652,592 | $1.3 million | 2025-12 |
| New Capernaum Life Services | 501(c)(3) | 2020 | $646,000 | $4.9 million | 2025-12 |
| Congaree Vista Guild | 501(c)(6) | 2005 | $581,300 | $168,958 | 2025-06 |
| Certified Development Corporation of South Carolina | 501(c)(3) | 1996 | $569,341 | $1.3 million | 2025-12 |
| Limitless Community Development Corp | 501(c)(3) | 2011 | $508,341 | $121,516 | 2025-12 |
| Navigating From Good To Greatfoundation | 501(c)(3) | 2007 | $385,399 | $254,305 | 2025-08 |
| Growco Columbia Inc | 501(c)(3) | 2019 | $367,881 | $351,146 | 2024-12 |
| South Carolina Association of Governmental Organizations | 501(c)(3) | 2004 | $314,958 | $865,707 | 2025-06 |
| Central Midlands Justice Ministry | 501(c)(3) | 2017 | $250,221 | $45,450 | 2025-12 |
| Dyslexia Reseource Center | 501(c)(3) | 2001 | $238,966 | $127,789 | 2025-12 |
| Southeast Governmental Fleet Managers Association | 501(c)(6) | 2014 | $222,674 | $143,377 | 2025-12 |
| South Carolina Radiation Quality Standards Association | 501(c)(3) | 2001 | $218,997 | $611,743 | 2025-12 |
| SC Association of Technical College Commissioners Inc | 501(c)(6) | 2005 | $178,075 | $75,127 | 2026-06 |
| Midlands Business Leadership Group | 501(c)(6) | 2010 | $171,500 | $390,760 | 2025-12 |
| Carolinas Public Gas Association | 501(c)(6) | 2018 | $160,534 | $140,751 | 2025-12 |
| Trauma Association of South Carolina | 501(c)(6) | 1999 | $147,891 | $98,903 | 2026-06 |
| Columbia Executives and Owners Association Inc | 501(c)(6) | 2005 | $137,866 | $103,274 | 2025-12 |
| Midlands Mediation Center | 501(c)(3) | 1998 | $129,163 | $114,564 | 2025-06 |
| Koinonia of Columbia Inc | 501(c)(3) | 2017 | $124,683 | $159,166 | 2025-12 |
| Independent Textile Rental Association Inc | 501(c)(6) | 2006 | $123,753 | $75,570 | 2025-12 |
| Columbia Opportunity Resource | 501(c)(3) | 2007 | $117,098 | $46,668 | 2025-06 |
| Devine Street Association | 501(c)(6) | 2015 | $114,890 | $4,535 | 2024-12 |
| Greater Rosewood Merchants Association | 501(c)(6) | 2011 | $113,035 | $745 | 2026-06 |
| Esther Project Shop | 501(c)(3) | 2020 | $106,713 | $95,987 | 2025-12 |
| Acercamiento Hispano de Carolina Del Sur | 501(c)(3) | 1997 | $104,829 | $66,139 | 2025-12 |
| Made With Cola Love | 501(c)(3) | 2023 | $100,000 | $77,602 | 2025-06 |
| South Carolina Downtown Development Association Inc | 501(c)(3) | 1984 | $98,691 | $68,831 | 2025-12 |
| South Carolina Recyclers Association | 501(c)(6) | 2011 | $97,921 | $128,949 | 2025-12 |
| Womens Transportation Seminar WTS - South Carolina Chapter | 501(c)(6) | 2021 | $79,515 | $46,034 | 2024-12 |
| Allergy Asthma and Immunology Society of South Carolina Inc | 501(c)(6) | 2015 | $77,278 | $262,619 | 2024-12 |
| Columbia Society for Human Resource Management | 501(c)(6) | 2011 | $72,688 | $140,761 | 2025-12 |
| South Carolina Equality | 501(c)(3) | 2005 | $67,743 | $64,222 | 2025-12 |
| Benedict-Allen Community Corp | 501(c)(3) | 1996 | $63,491 | $525,982 | 2024-06 |
| South Carolina Brewers Guild | 501(c)(6) | 2017 | $58,979 | $46,945 | 2024-12 |
| South Carolina Mitigation Association | 501(c)(6) | 2020 | $51,638 | $64,152 | 2025-12 |
| Columbia Hebrew Benevolent Society | 501(c)(3) | 1952 | $50,810 | $458,772 | 2025-04 |
| North Columbia Business Association | 501(c)(6) | 2009 | $49,880 | $23 | 2023-12 |
| Delta House Inc | 501(c)(3) | 2012 | $46,019 | $21,934 | 2024-12 |
| Exchange Network | 501(c)(6) | 2017 | $45,021 | $39,979 | 2025-12 |
| South Carolina Electronic Security and Technology Association | 501(c)(6) | 2021 | $41,952 | $83,014 | 2025-12 |
| American Council of Engineering Cos of SC Infrastructure Works Instit | 501(c)(3) | 2025 | $36,285 | $84,158 | 2025-06 |
| Wog Community Development Corporation | 501(c)(3) | 2017 | $28,000 | $15,379 | 2024-06 |
| Edgewood Foundation | 501(c)(3) | 2001 | $15,838 | $8,362 | 2025-12 |
| Palmetto Paralegal Association Inc | 501(c)(6) | 2000 | $11,481 | $22,717 | 2025-12 |
| Rotary Club of Main Street | 501(c)(4) | 2019 | $11,019 | $22,636 | 2025-06 |
| BBC Community Development Corp Bethlehem Baptist Church | 501(c)(3) | 2021 | $10,950 | $3,224 | 2025-12 |
| South Carolina Equality Coalition | 501(c)(4) | 2005 | $10,415 | $11,843 | 2025-12 |
| American College of Healthcare Executives | 501(c)(6) | 1983 | $0 | $0 | 2025-12 |
| American Marketing Association Inc | 501(c)(3) | 1992 | $0 | $0 | 2024-06 |
| Association of Chapter Twelve Trustees | 501(c)(6) | 2022 | $0 | $0 | 2026-06 |
| Atlas RD Community Organization | 501(c)(3) | 2015 | $0 | $0 | 2024-12 |
| Brandon Acres Cedar Terrace Neighborhood Association | 501(c)(3) | 2024 | $0 | $0 | 2024-12 |
| Bridging the Gap Community Wellness Institute | 501(c)(3) | 2024 | $0 | $0 | 2025-12 |
| Changing Lives Christian Center Community Development Corporation | 501(c)(3) | 2022 | $0 | $0 | 2024-12 |
| Christ Teens | 501(c)(3) | 2007 | $0 | $0 | 2025-06 |
| Columbia Fire Family Association | 501(c)(3) | 2017 | $0 | $0 | 2025-12 |
| Columbia Resilience | 501(c)(3) | 2014 | $0 | $0 | 2025-12 |
| Columbias Insurance and Technology Services Cluster | 501(c)(6) | 2019 | $0 | $0 | 2025-06 |
| Community Resource Collective | 501(c)(3) | 2026 | | | |
| Conexion Empresarial Latina | 501(c)(3) | 2025 | | | |
| Creeklife Foundation Inc | 501(c)(3) | 2026 | | | |
| Crew Midlands South Carolina | 501(c)(6) | 2010 | $0 | $0 | 2024-12 |
| Decker Boulevard Business Coalition | 501(c)(3) | 2014 | $0 | $0 | 2024-12 |
| Earlewood Community Citizens Organization | 501(c)(3) | 2010 | $0 | $0 | 2026-06 |
| Executive Womens Golf Association Inc | 501(c)(6) | 1997 | $0 | $0 | 2025-12 |
| F U N D S Inc | 501(c)(3) | 1998 | $0 | $0 | 2025-12 |
| Forest Acres Beautification Foundation | 501(c)(3) | 2020 | | | |
| Foundation for Heathwood Hall Inc | 501(c)(3) | 1995 | $0 | $0 | 2024-12 |
| Friendly Atmosphere Mentoring | 501(c)(3) | 2020 | $0 | $0 | 2024-06 |
| Front Runnerz MC | 501(c)(3) | 2023 | $0 | $0 | 2025-09 |
| Galaxy Neighborhood Association | 501(c)(3) | 2023 | $0 | $0 | 2025-12 |
| Greater Historic Waverly Development Corporation | 501(c)(3) | 2023 | | | |
| Greater Lower Richland Chamber of C Ommerce | 501(c)(6) | 2026 | | | |
| Green Knoll Project | 501(c)(3) | 2017 | $0 | $0 | 2025-12 |
| Greenview Community Club | 501(c)(3) | 2024 | | | |
| Growth Collective Inc | 501(c)(3) | 2026 | | | |
| Hba CDC | 501(c)(3) | 2014 | $0 | $0 | 2025-12 |
| Here | 501(c)(3) | 2024 | $0 | $0 | 2025-12 |
| Historic Heathwood Neighborhood Association Inc | 501(c)(3) | 2009 | $0 | $0 | 2025-12 |
| Hollywood Rose Hill Neighborhood Association | 501(c)(3) | 2016 | $0 | $0 | 2025-12 |
| Hooping for Donte Inc | 501(c)(3) | 2023 | $0 | $0 | 2023-12 |
| Hopkins Chiefs | 501(c)(3) | 2024 | $0 | $0 | 2025-12 |
| Hyatt Park Keenan Terrace Neighborhood Association | 501(c)(3) | 2021 | $0 | $0 | 2024-12 |
| Iiba Palmetto Chapter Inc | 501(c)(6) | 2019 | $0 | $0 | 2025-12 |
| Independent Insurance Agents of South Carolina Foundation Incorpor | 501(c)(3) | 1985 | | $668,838 | 2025-12 |
| Janycois Building Community | 501(c)(3) | 2025 | $0 | $0 | 2025-12 |
| Jones Memorial CDC | 501(c)(3) | 2014 | $0 | $0 | 2024-12 |
| Kiwanis Club of Columbia Golden K Foundation | 501(c)(3) | 2017 | $0 | $0 | 2025-12 |
| Lakeview Foundation | 501(c)(3) | 2022 | $0 | $0 | 2026-06 |
| Lambda Psi Alpha | 501(c)(3) | 2021 | $0 | $0 | 2025-12 |
| Laugh for Life | 501(c)(3) | 2023 | $0 | $0 | 2025-12 |
| Living Cola Cares | 501(c)(3) | 2024 | $0 | $0 | 2025-12 |
| Mary L Jacobs Life Center | 501(c)(3) | 2020 | $0 | $0 | 2025-12 |
| Melius Forum | 501(c)(6) | 2023 | $0 | $0 | 2025-12 |
| Mentoring Individuals Nurturing Dre Ams | 501(c)(3) | 2026 | | | |
| Mighty Chariotwheel Stewardship & Learning Center | 501(c)(3) | 2021 | $0 | $0 | 2025-06 |
| Mud Color Inc | 501(c)(3) | 2023 | $0 | $0 | 2024-12 |
| National Coalition of 100 Black Women Inc -Columbia SC Chapter | 501(c)(3) | 2018 | $0 | $0 | 2025-09 |
| National Counc of Negro Women Inc | 501(c)(3) | 1966 | $0 | $0 | 2024-09 |
| Neighborhood Connection Outreach | 501(c)(3) | 2025 | | | |
| New Generation Thrift | 501(c)(3) | 2024 | $0 | $0 | 2023-12 |
| Noma Foundation | 501(c)(3) | 2024 | | | |
| Non Profit Assistants Inc | 501(c)(3) | 2011 | $0 | $0 | 2024-12 |
| Odis Ella Foundation | 501(c)(3) | 2023 | $0 | $0 | 2023-12 |
| Optus Community Capital | 501(c)(3) | 2024 | $0 | $0 | 2025-12 |
| Palmetto Family Alliance Inc | 501(c)(4) | 1999 | $0 | $0 | 2025-12 |
| Palmetto Progressive Community Development Corporation | 501(c)(3) | 2014 | $0 | $0 | 2025-01 |
| Pinewood Lake Park Foundation | 501(c)(3) | 2016 | $0 | $0 | 2025-12 |
| Positive Coalition Project | 501(c)(3) | 2024 | | | |
| Potters House Community Development Inc | 501(c)(3) | 2014 | $0 | $0 | 2025-12 |
| Qualified Plans Southeast Inc | 501(c)(6) | 2004 | $0 | $0 | 2023-12 |
| Real Life Ministries of America | 501(c)(3) | 2007 | $0 | $0 | 2024-12 |
| Responsible Growth for Kershaw County | 501(c)(3) | 2007 | $0 | $0 | 2025-12 |
| Richland County Economic Development Public Private Partner | 501(c)(3) | 2025 | | | |
| Richland County Neighborhood Council | 501(c)(3) | 2023 | $0 | $0 | 2025-06 |
| Ridgewood Foundation Inc | 501(c)(3) | 1991 | $0 | $0 | 2023-09 |
| Rotary Club of Columbia East | 501(c)(4) | 2025 | $0 | $0 | 2025-06 |
| Rural Growth Initiative | 501(c)(3) | 2023 | $0 | $0 | 2025-06 |
| SC Association of Farmers Markets | 501(c)(3) | 2009 | $0 | $0 | 2024-12 |
| Set Free Community Development Corporation | 501(c)(3) | 2017 | $0 | $0 | 2025-12 |
| Seyue Foundation | 501(c)(3) | 2022 | $0 | $0 | 2025-12 |
| Shandon Neighborhood Council | 501(c)(3) | 2017 | $0 | $0 | 2025-12 |
| Sigma Gamma Rho Sorority Inc | 501(c)(3) | 1982 | $0 | $0 | 2026-06 |
| Small Business Chamber Foundation | 501(c)(3) | 2010 | $0 | $0 | 2024-12 |
| South Carolina Administrative and Regulatory Law Association | 501(c)(6) | 2003 | $0 | $0 | 2025-06 |
| South Carolina Agritourism Association | 501(c)(6) | 2015 | $0 | $0 | 2025-12 |
| South Carolina Bar Advancement of T He Profession Foundation | 501(c)(3) | 2026 | | | |
| South Carolina Foundation for Agriculture | 501(c)(6) | 2025 | $0 | $0 | 2021-12 |
| South Carolina Pha York Rite Assembly | 501(c)(3) | 2025 | | | |
| South Carolina Society of Echocardiography | 501(c)(6) | 2019 | $0 | $0 | 2025-12 |
| South Carolina Society of Intrventional Pain Physicians Inc | 501(c)(6) | 2002 | $0 | $0 | 2025-12 |
| South Carolina Wrestling Officials Association | 501(c)(6) | 2003 | $0 | $0 | 2025-12 |
| Spread Love World Foundation | 501(c)(3) | 2024 | | | |
| Strength of A Woman By MS GG | 501(c)(3) | 2025 | $0 | $0 | 2025-12 |
| Surviving Against the Odds Community Development Group | 501(c)(3) | 2023 | $0 | $0 | 2025-12 |
| Talented Tenth | 501(c)(3) | 2018 | $0 | $0 | 2025-12 |
| Tee Professional Connections Network | 501(c)(3) | 2022 | $0 | $0 | 2025-12 |
| The Hi T Society | 501(c)(3) | 2018 | $0 | $0 | 2025-07 |
| The Waiting Well Project Inc | 501(c)(3) | 2026 | | | |
| Thriving Families Collaborative | 501(c)(3) | 2025 | | | |
| Turning Point Community Outreach | 501(c)(3) | 2025 | | | |
| Whaley Street Neighborhood Organization | 501(c)(3) | 2006 | $0 | $0 | 2025-12 |
| With This Purpose Missions | 501(c)(3) | 2021 | $0 | $0 | 2024-06 |
| Women On the Move SC | 501(c)(3) | 2023 | | $1 | 2025-12 |
| Woodlake Home & Garden Club | 501(c)(4) | 2009 | $0 | $0 | 2025-06 |