Data / Drug companies / Folate Analog Metabolic Inhibitor
Folate Analog Metabolic Inhibitor drugs: 6 drugs from 56 companies in the FDA NDC directory
Updated November 6, 2026. Source: US Food and Drug Administration, National Drug Code Directory (openFDA).
Folate Analog Metabolic Inhibitor is an FDA established pharmacologic class. The FDA National Drug Code Directory lists 152 products in this class from 56 companies, covering 6 drugs by generic name. The main marketing category is generic drugs (ANDA), and the newest product started marketing on October 29, 2026.
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- 56Companies
- 152Products
- 6Drugs by generic name
Drugs in the Folate Analog Metabolic Inhibitor class
Ranked by number of companies that list the drug.
| Drug | Products here | Companies listing it |
|---|---|---|
| Methotrexate | 72 | 31 |
| Pemetrexed disodium | 44 | 14 |
| Pemetrexed | 22 | 9 |
| Methotrexate sodium | 6 | 5 |
| Pralatrexate | 6 | 3 |
| Pemetrexed dipotassium | 2 | 1 |
Companies with the most products in this class
| Company | Products | Main dosage forms | Main marketing category | Newest product started |
|---|---|---|---|---|
| Medexus Pharma, Inc. | 9 | injection, solution | New drug applications (NDA) | July 10, 2014 |
| BluePoint Laboratories | 8 | injection, powder, lyophilized, for solution | Generic drugs (ANDA) | February 28, 2023 |
| Meitheal Pharmaceuticals Inc. | 8 | injection, powder, lyophilized, for solution | Generic drugs (ANDA) | December 13, 2022 |
| Antares Pharma, Inc. | 7 | injection, solution | New drug applications (NDA) | October 11, 2013 |
| Eugia US LLC | 7 | injection, solution; injection, powder, lyophilized, for solution | Generic drugs (ANDA) | September 11, 2024 |
| Fresenius Kabi USA, LLC | 6 | injection, powder, lyophilized, for solution; injection, solution | Generic drugs (ANDA) | May 25, 2022 |
| Hikma Pharmaceuticals USA Inc. | 6 | solution; injection, powder, lyophilized, for solution | Generic drugs (ANDA) | January 5, 2018 |
| Hospira, Inc. | 6 | injection, solution | New drug applications (NDA) | November 4, 2024 |
| Hospira, Inc. | 6 | injection, solution, concentrate | New drug applications (NDA) | February 1, 2023 |
| Accord Healthcare Inc. | 5 | injection, powder, lyophilized, for solution; injection | Generic drugs (ANDA) | May 25, 2022 |
| Dr. Reddy's Laboratories Inc. | 5 | injection, powder, lyophilized, for solution; injection | Generic drugs (ANDA) | March 4, 2026 |
| Avyxa Pharma, LLC | 4 | injection, powder, lyophilized, for solution | New drug applications (NDA) | January 1, 2025 |
| Bryant Ranch Prepack | 4 | tablet | Generic drugs (ANDA) | August 24, 2020 |
| Teva Women's Health LLC | 4 | tablet, film coated | Generic drugs (ANDA) | May 3, 2001 |
| Alembic Pharmaceuticals Inc. | 3 | injection, solution; tablet | Generic drugs (ANDA) | April 15, 2026 |
| Alembic Pharmaceuticals Limited | 3 | injection, solution; tablet | Generic drugs (ANDA) | April 15, 2026 |
| Amneal Pharmaceuticals LLC | 3 | injection | New drug applications (NDA) | June 6, 2023 |
| Sandoz Inc | 3 | injection, solution | New drug applications (NDA) | June 8, 2022 |
| Shilpa Medicare Limited | 3 | injection | New drug applications (NDA) | January 1, 2024 |
| Teva Parenteral Medicines, Inc. | 3 | injection, solution | Generic drugs (ANDA) | August 1, 2012 |
| Teva Pharmaceuticals, Inc. | 3 | solution, concentrate | New drug applications (NDA) | June 1, 2022 |
| Acrotech Biopharma Inc | 2 | injection | New drug applications (NDA) | September 24, 2009 |
| Bryant Ranch Prepack | 2 | tablet | Generic drugs (ANDA) | June 4, 2024 |
| Camber Pharmaceuticals, Inc. | 2 | injection, powder, lyophilized, for solution | Generic drugs (ANDA) | June 14, 2024 |
| Eli Lilly and Company | 2 | injection, powder, lyophilized, for solution | New drug applications (NDA) | September 7, 2007 |
| Fresenius Kabi USA, LLC | 2 | injection | Authorized generics (NDA) | November 15, 2022 |
| NorthStar RxLLC | 2 | injection, powder, lyophilized, for solution | Generic drugs (ANDA) | October 1, 2024 |
| NuCare Pharmaceuticals,Inc. | 2 | tablet | Generic drugs (ANDA) | August 24, 2020 |
| Qilu Pharmaceutical Co., Ltd. | 2 | injection, powder, lyophilized, for solution | Generic drugs (ANDA) | May 25, 2022 |
| Sagent Pharmaceuticals | 2 | injection, powder, lyophilized, for solution | Generic drugs (ANDA) | December 15, 2024 |
| Somerset Therapeutics, LLC | 2 | injection, powder, lyophilized, for solution | Generic drugs (ANDA) | April 15, 2025 |
| Waverley Pharma Inc | 2 | injection, powder, lyophilized, for solution | Generic drugs (ANDA) | June 4, 2018 |
| A-S Medication Solutions | 1 | tablet | Generic drugs (ANDA) | November 1, 1990 |
| Acacia Pharma, Ltd. | 1 | injection | New drug applications (NDA) | June 22, 2026 |
| American Health Packaging | 1 | tablet | Generic drugs (ANDA) | October 29, 2026 |
| Aurobindo Pharma Limited | 1 | tablet | Generic drugs (ANDA) | January 30, 2020 |
| AvKARE | 1 | tablet | Generic drugs (ANDA) | November 20, 2014 |
| AvPAK | 1 | tablet | Generic drugs (ANDA) | January 29, 2026 |
| Azurity Pharmaceuticals, Inc. | 1 | solution | New drug applications (NDA) | May 1, 2017 |
| Chartwell RX, LLC | 1 | tablet | Generic drugs (ANDA) | January 30, 2020 |
| Coupler LLC | 1 | tablet | Generic drugs (ANDA) | February 27, 2025 |
| Eagle Pharmaceuticals, Inc. | 1 | injection | New drug applications (NDA) | February 1, 2022 |
| Elite Laboratories, Inc. | 1 | tablet | Generic drugs (ANDA) | May 16, 2024 |
| Golden State Medical Supply, Inc. | 1 | tablet | Generic drugs (ANDA) | May 15, 1992 |
| Hikma Pharmaceuticals USA Inc. | 1 | tablet | Generic drugs (ANDA) | August 1, 1994 |
| Major Pharmaceuticals | 1 | tablet | Generic drugs (ANDA) | February 9, 2017 |
| Mylan Institutional Inc. | 1 | tablet | Generic drugs (ANDA) | July 13, 1995 |
| Mylan Pharmaceuticals Inc. | 1 | tablet | Generic drugs (ANDA) | May 18, 1992 |
| Proficient Rx LP | 1 | tablet | Generic drugs (ANDA) | August 24, 2020 |
| Safecor Health, LLC | 1 | tablet | Generic drugs (ANDA) | January 19, 2026 |
| Shorla Oncology Inc. | 1 | solution | New drug applications (NDA) | December 15, 2023 |
| Solco Healthcare US, LLC | 1 | injection, powder, for solution | Generic drugs (ANDA) | July 1, 2024 |
| Sun Pharmaceutical Industries, Inc. | 1 | tablet | Generic drugs (ANDA) | November 10, 2017 |
| Teva Pharmaceuticals USA, Inc. | 1 | tablet | Generic drugs (ANDA) | November 1, 1990 |
| Zydus Lifesciences Limited | 1 | tablet | Generic drugs (ANDA) | February 9, 2017 |
| Zydus Pharmaceuticals USA Inc. | 1 | tablet | Generic drugs (ANDA) | February 9, 2017 |
Dosage forms
| Dosage form | Products | Share |
|---|---|---|
| Injection, powder, lyophilized, for solution | 50 | 32.9% |
| Injection, solution | 37 | 24.3% |
| Tablet | 30 | 19.7% |
| Injection | 15 | 9.9% |
| Solution | 6 | 3.9% |
| Injection, solution, concentrate | 6 | 3.9% |
| Tablet, film coated | 4 | 2.6% |
| Solution, concentrate | 3 | 2% |
| Injection, powder, for solution | 1 | 0.7% |
CC0 1.0 public domain dedication (openFDA). Counts are products in the FDA National Drug Code Directory on November 6, 2026: 138,262 products in commercial distribution, meaning without a marketing end date in the past. A company is a labeler code; one company can hold several codes, and the directory carries no address. Inclusion in the directory is not FDA approval, and the marketing category says under which kind of application or rule a product is sold. This page uses openFDA data and is not endorsed or certified by FDA. Free to reuse with credit to SpecStream under CC BY 4.0. Spot a wrong value? Write to [email protected] with the link to this page.