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Data / Research funding / Stem Cell Research - Induced Pluripotent Stem Cell

Stem Cell Research - Induced Pluripotent Stem Cell: 1,451 NIH awards ($1.4B) to 303 organizations

1,451 NIH awards ($1.4B) in the NIH spending category Stem Cell Research - Induced Pluripotent Stem Cell, to 303 organizations, read 2026-11-03. NIH fiscal years 2021 to 2025.

SpecStream is the live web data engine for teams and agents. It reads the NIH and NSF award files each time the agencies update them, and this page is that reading, joined to the open federal funding opportunities on Grants.gov. Ask for the awards you track by topic, organization or state and new awards arrive in your sheet, CRM, Slack or agent as the agencies publish them.

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Awards

The 500 largest of 1,451 awards in the window.

AwardAgencyInstitute or divisionFiscal yearAmount in windowStartEndPrincipal investigatorSource
Limited Competition: Continuation of the Center for Genomic Studies on Mental DisordersNIHNational Institute of Mental Health2021 to 2024$39,202,732July 1, 2003February 28, 2026KNOWLES, JAMES Areporter.nih.gov
UCCC P30 Supplement: Human Endogenous Retrovirus-H as a Target for Early-Onset Colorectal CancerNIHNational Cancer Institute2021 to 2025$21,851,455September 1, 2025August 31, 2026SCHULICK, RICHARD Dreporter.nih.gov
Nebraska Research Network in Functional GenomicsNIHNational Institute of General Medical Sciences2021 to 2025$20,833,603September 30, 2001April 30, 2026SORGEN, PAUL Lreporter.nih.gov
CWRU Center for Excellence on the Impact of Substance Use on HIVNIHNational Institute on Drug Abuse2021 to 2025$16,213,687September 15, 2021May 31, 2027LEVINE, ALAN DAVIDreporter.nih.gov
The Alzheimer's Disease Research Center at the University of California, IrvineNIHNational Institute on Aging2021 to 2025$16,032,156June 15, 2020March 31, 2030LAFERLA, FRANK Mreporter.nih.gov
Therapeutic gene editing and multimodal imaging in juvenile macular degenerationNIHNational Eye Institute2021 to 2024$8,710,741June 1, 2020May 31, 2026TSANG, STEPHEN Hreporter.nih.gov
Parkinsons Disease Scalable iPSC Autologous Cell TherapyNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$7,528,144January 1, 2020December 31, 2025HALLETT, PENELOPE JANEreporter.nih.gov
IGF::OT::IGFEMMES NEIS-VNIHOffice of the Director, National Institutes of Health2021$7,315,897November 1, 2016October 31, 2021HAMMEL, KERIreporter.nih.gov
Functional Interrogation of T2D-associated genes in human stem cell-derived models and miceNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2024$6,998,766August 20, 2020June 30, 2025SEALE, PATRICKreporter.nih.gov
FMRP-mediated Regulation in Human Brain Development and Therapeutic AdvancementNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2021 to 2024$6,546,370September 25, 2020June 30, 2025JIN, PENGreporter.nih.gov
From proteins to cells to tissues: A multi-scale assessment of biomechanical regulation by the myosin molecular motorNIHNational Institute of General Medical Sciences2021 to 2023$6,459,020May 15, 2019April 30, 2025BERNSTEIN, DANIELreporter.nih.gov
Molecular Circuits in the Hematopoietic Stem Cell NicheNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2024$6,422,507August 15, 2020May 31, 2025DALEY, GEORGE Qreporter.nih.gov
Metals and Metal Mixtures: Cognitive Aging, Remediation and Exposure Sources (MEMCARE)NIHNational Institute of Environmental Health Sciences2021 to 2024$6,396,550February 21, 2020May 9, 2025LU, QUANreporter.nih.gov
Development of PU.1 Inhibitory Modulators as Novel Therapeutics for Alzheimer's DiseaseNIHNational Institute on Aging2021 to 2024$6,353,055May 15, 2020April 30, 2026TSAI, LI-HUEIreporter.nih.gov
Integrating large scale genomics and functional studies to accelerate FSGS/NS discoveryNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2024$5,901,662August 15, 2020May 31, 2026POLLAK, MARTIN R.reporter.nih.gov
A Human iPSC-based Cell Therapy for Canavan DiseaseNIHNational Institute of Neurological Disorders and Stroke2021 to 2023$5,276,950June 15, 2021May 31, 2027SHI, YANHONGreporter.nih.gov
Microphysiological systems to interrogate the Islet-Liver-Adipose Axis in normal physiology and Type-2 Diabetes MellitusNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2022$4,582,323September 20, 2018July 31, 2024STAHL, ANDREASreporter.nih.gov
Illuminating Function of the Understudied Druggable KinomeNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2022$4,503,990September 15, 2017December 31, 2024JOHNSON, GARY L.reporter.nih.gov
UAB Childhood Cystic Kidney Disease Center (UAB-CCKDC)NIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2025$4,330,298July 20, 2020August 31, 2030YODER, BRADLEY K.reporter.nih.gov
Human Microphysiology Systems Disease Model of Type 2 Diabetes Starting with Liver and pancreatic IsletsNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2022$4,324,679September 20, 2018July 31, 2023TAYLOR, D. LANSINGreporter.nih.gov
Development and Expansion of the Human Cerebral CortexNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$4,211,732December 1, 2016November 30, 2024KRIEGSTEIN, ARNOLDreporter.nih.gov
Genetic neuroscience: How human genes and alleles shape neuronal phenotypesNIHNational Institute of Mental Health2021$4,026,586September 20, 2017July 31, 2023MCCARROLL, STEVEN ANDREWreporter.nih.gov
BIOREPOSITORY OF HUMAN INDUCED PLURIPOTENT STEM CELLSFORCARDIOVASCULAR DISEASES (BHIPSC-CVD)- TASK A. CORE STUDY OPERATIONSNIHNational Heart, Lung, and Blood Institute2021 to 2024$3,969,819September 1, 2020August 31, 2025WU, JOSEPHreporter.nih.gov
Basic Investigation and Translational Applications Concerning the Cell and Molecular Biology of Blood and Vascular CellsNIHNational Heart, Lung, and Blood Institute2021 to 2024$3,926,545March 1, 2018February 28, 2026NEWMAN, PETER Jreporter.nih.gov
Study of cell-type specific Alzheimer's disease genetic variants using a novel bioengineered model of iPSC-derived neural tissueNIHNational Institute on Aging2021 to 2024$3,903,556May 1, 2020April 30, 2026TESCO, GIUSEPPINAreporter.nih.gov
Perturbing the LXR/SREBP axis to decipher protective and pathogenic AD/ADRD microglial phenotypesNIHNational Institute on Aging2024$3,840,870May 1, 2024April 30, 2027GLASS, CHRISTOPHER Kreporter.nih.gov
A two-pronged approach to generating novel models of photoreceptor degeneration for regenerative cell therapyNIHNational Eye Institute2021 to 2024$3,781,701September 30, 2021July 31, 2026FU, YINGBINreporter.nih.gov
Elucidating the Biological Differences Between Distinct Fibrillar and Non-Fibrillar Alpha-Synuclein Inclusions in Human Stem-Cell ModelsNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$3,706,946July 1, 2020April 30, 2026KHURANA, VIKRAMreporter.nih.gov
Cellular consequences and convergent biology of schizophrenia-associated rare variants in the diverse GPC cohortNIHNational Institute of Mental Health2022 to 2024$3,678,769August 1, 2022May 31, 2027MULLE, JENNIFER GLADYSreporter.nih.gov
Construction of an Integrated Immune - Vascular Brain - Chip as a Platform for the Study, Drug Screening, and Treatments of Alzheimer's DiseaseNIHNational Institute of Neurological Disorders and Stroke2021 to 2023$3,475,569September 20, 2019May 31, 2024TSAI, LI-HUEIreporter.nih.gov
Functional roles of genetic risk factors for brain disorders in neurogenesis and neurodevelopmentNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$3,437,163December 1, 2016November 30, 2024MING, GUO-LIreporter.nih.gov
Novel Network Biology Approaches to Reposition FDA-approved Drugs for Alzheimer's DiseaseNIHNational Institute on Aging2021 to 2024$3,386,194September 15, 2020May 31, 2026ZHANG, BINreporter.nih.gov
Microphysiological systems for modeling autoimmunity in type 1 diabetesNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2023$3,372,768August 2, 2019July 31, 2025STANGER, BEN Zreporter.nih.gov
Genetic Control of Cardiac Development: Congenital Heart Disease Gene Discovery in DrosophilaNIHNational Heart, Lung, and Blood Institute2021 to 2024$3,338,929August 1, 1995June 30, 2025BODMER, ROLFreporter.nih.gov
Enhancer-based Immune and Beta Cell Dysregulation Underlying T1D RiskNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2023$3,303,112September 15, 2020June 30, 2025SUH, YOUSINreporter.nih.gov
Cell specific delivery of novel therapies to enhance glomerular regeneration and repairNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2024$3,199,320September 1, 2020May 31, 2025SHANKLAND, STUART JAMESreporter.nih.gov
Aging, Polypharmacy and Neurotoxicity in Adults Living with HIVNIHNational Institute on Aging2021 to 2024$3,183,836May 1, 2020February 28, 2026MA, QINGreporter.nih.gov
Ex Vivo Generation of Functional Kidney Tissues for TransplantationNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2024$3,161,308September 1, 2020May 14, 2025LEWIS, JENNIFER A.reporter.nih.gov
Modeling diabetes using an integrated plate systemNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2022$3,092,998September 20, 2018July 31, 2024WELLS, JAMES Mreporter.nih.gov
Genetic determinants of 4D genome folding in human cardiac developmentNIHNational Heart, Lung, and Blood Institute2021 to 2024$3,069,960September 21, 2020August 31, 2025BRUNEAU, BENOIT GAETANreporter.nih.gov
Retinal Ganglion Cell Replacement in Clinically Relevant Models of Optic NeuropathyNIHNational Eye Institute2021 to 2022$3,026,491September 30, 2018August 31, 2024REX, TONIA Sreporter.nih.gov
Investigating the role of adipose tissue in mobility and aging (SOMMA-AT)NIHNational Institute on Aging2021 to 2024$3,021,652September 15, 2020May 31, 2025SPARKS, LAUREN MARIEreporter.nih.gov
Towards a better understanding of genetic architecture of Alzheimer's disease with human iPSC modelsNIHNational Institute on Aging2021 to 2024$3,018,880August 15, 2020April 30, 2026WEN, ZHEXINGreporter.nih.gov
A 3D vascularized islet biomimetic to model type 1 diabetesNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2023$3,017,660August 1, 2019January 31, 2025SANDER, MAIKEreporter.nih.gov
Harnessing human brain and liver microphysiological systems for testing therapeutics for metastatic melanomaNIHNational Center for Advancing Translational Sciences2021 to 2022$3,003,024August 1, 2018July 31, 2024WIKSWO, JOHN PETERreporter.nih.gov
BRITE-Eye: An integrated discovery engine for CNS therapeutic targets driven by high throughput genetic screens, functional readouts in human neurons, and machine learningNIHNational Institute of Mental Health2023 to 2024$2,999,997September 19, 2023August 31, 2025WILLIAMS, LUIS ALBERTOreporter.nih.gov
Impact of peripheral nerves on mesenchymal cell fate in extremity traumaNIHNational Institute of Arthritis and Musculoskeletal and Skin Diseases2021 to 2024$2,991,689August 1, 2017April 30, 2026LEVI, BENJAMINreporter.nih.gov
Defining Genetic Architecture and Pathways of DCMNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,976,096April 1, 2005January 31, 2026SEIDMAN, JONATHAN Greporter.nih.gov
TREM2-mediated microglial dynamic function in Alzheimer diseaseNIHNational Institute on Aging2021 to 2024$2,968,448February 1, 2020December 31, 2025ZHAO, NAreporter.nih.gov
Defining disease mechanisms in SLC35A2 epilepsyNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$2,951,492July 1, 2020April 30, 2025HEINZEN, ERIN Lreporter.nih.gov
Defining the Mechanistic Basis for Neurofibromatosis-1 Nervous System Disease HeterogeneityNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$2,950,878December 1, 2016November 30, 2024GUTMANN, DAVID Hreporter.nih.gov
Cell and Network Disruptions and Associated Pathogenenesis in Tauopathy and Down SyndromeNIHNational Institute on Aging2021 to 2024$2,943,744April 15, 2020March 31, 2026FINKBEINER, STEVEN Mreporter.nih.gov
Polyunsaturated fatty acids as anti-arrhythmic agents.NIHNational Heart, Lung, and Blood Institute2021 to 2024$2,942,029September 15, 2016March 31, 2026BARRO-SORIA, RENEreporter.nih.gov
Mechanistic Basis of Cardiac LaminopathyNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,934,243September 16, 2021June 30, 2026WORMAN, HOWARD Jreporter.nih.gov
Identifying Alzheimer’s Disease Causal Variants and Target Genes Using iPSC-derived MicrogliaNIHNational Institute on Aging2021 to 2024$2,922,756April 15, 2020March 31, 2025PHANSTIEL, DOUGLAS H.reporter.nih.gov
Induced neuronal cells: A novel tool to study neuropsychiatric diseasesNIHNational Institute of Mental Health2021 to 2024$2,918,957September 29, 2010August 31, 2025WERNIG, MARIUSreporter.nih.gov
Dissecting the role of NOTCH2NL genes in human brain development and neurological disorders associated with chromosome 1q21.1 distal duplications and deletions.NIHNational Institute of Mental Health2021 to 2024$2,907,904April 15, 2020January 31, 2026SALAMA, SOFIE REDAreporter.nih.gov
Retinal disease models for translational photoreceptor replacementNIHNational Eye Institute2021 to 2022$2,898,123September 30, 2018May 31, 2025WOLFE, JOHN Hreporter.nih.gov
Study the Protective Roles of ApoE2 in Alzheimer's Disease Using Reprogrammed Isogenic CellsNIHNational Institute on Aging2021 to 2024$2,897,144May 1, 2020March 31, 2025HUANG, YADONGreporter.nih.gov
Implementing a coupled system of integrative ML modeling and data validation for elucidating microglial therapeutic targets in neurodegenerative diseaseNIHNational Institute of Mental Health2023 to 2024$2,885,988September 15, 2023August 31, 2025SACHS, KARENreporter.nih.gov
The Pathogenesis of RNA Splicing Factor Associated Retinal DegenerationNIHNational Eye Institute2021 to 2024$2,874,308April 1, 2011March 31, 2026PIERCE, ERIC Areporter.nih.gov
Translational assessment of brain bioenergetic function in schizophreniaNIHNational Institute of Mental Health2021 to 2024$2,863,277December 1, 2019October 31, 2025MARANO, CHRISTOPHERreporter.nih.gov
Phenotyping Genetic Disorders of Hepatic Lipid and Lipoprotein Metabolism in Cells, Mice, and MenNIHNational Heart, Lung, and Blood Institute2021 to 2023$2,861,646January 1, 2017December 31, 2024GINSBERG, HENRY Nreporter.nih.gov
Single Cell Transciptomics of the Opioid Use Disorder and HIV Syndemic in the Human BrainNIHNational Institute on Drug Abuse2022 to 2024$2,859,989September 1, 2022August 31, 2025CHENG, CHRISTINEreporter.nih.gov
Beyond the Barrier: Alveolar Epithelial Cell Biology in Health and DiseaseNIHNational Heart, Lung, and Blood Institute2021 to 2023$2,844,000August 15, 2021June 30, 2025BOROK, ZEAreporter.nih.gov
Developing Cone-Dominant Retinal Disease Models as a Resource for Translational Vision ResearchNIHNational Eye Institute2021 to 2022$2,820,106September 30, 2018August 31, 2022CARROLL, JOSEPHreporter.nih.gov
Genotype-guided therapy for atrial fibrillationNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,771,945July 15, 2020June 30, 2026DARBAR, DAWOODreporter.nih.gov
Combined Cardiomyopathy, e.g., of Cancer Chemotherapeutics, and Proarrhythmia for Cardiotoxicity Clinical Trials-in-a-Dish (CTiD) with iPSC-Derived CardiomyocytesNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,764,144June 1, 2021July 31, 2025PRICE, JEFFREY H.reporter.nih.gov
Defining mechanisms of aortic root aneurysm in Loeys-Dietz syndrome using patients’ induced pluripotent stem cells and genome editingNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,760,413May 1, 2020April 30, 2026YANG, BOreporter.nih.gov
Ethnically Diverse iPSC-Cardiomyocyte Panel for Pharmacogenomics and Drug Safety TestingNIHNational Heart, Lung, and Blood Institute2023 to 2024$2,741,939September 5, 2023August 31, 2025AHMED, SYED MUKHTARreporter.nih.gov
Sex-specific Molecular Profiling to Understand Pathology and Identify Causal Genes and Drug Targets for Alzheimer's DiseaseNIHNational Institute on Aging2021$2,740,705September 30, 2021August 31, 2024SUNG, YUNJUreporter.nih.gov
Synergistic Mechanisms of chronic Innate Immune Activation in Microglia by Opiates and HIV InfectionNIHNational Institute on Drug Abuse2021 to 2024$2,732,942July 15, 2020April 30, 2026GUMMULURU, SURYARAMreporter.nih.gov
Charting the 3D epigenome in human brain development and diseasesNIHNational Institute on Drug Abuse2021 to 2024$2,724,871September 30, 2020August 31, 2025SHEN, YINreporter.nih.gov
1/7 Collaborative Genomic Studies of Tourette Disorder.NIHNational Institute of Mental Health2021 to 2023$2,683,588June 15, 2018March 31, 2025HEIMAN, GARY A.reporter.nih.gov
Defining Characteristics of Cortical Progenitor Cells over Time in Mouse and HumanNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$2,620,540December 15, 2016November 30, 2025TEMPLE, SALLYreporter.nih.gov
Contributions of cell type and exosome signaling to prodromal synaptic and circuit changes in Alzheimer's Disease modelsNIHNational Institute on Aging2022$2,618,631August 15, 2022July 31, 2025CLINE, HOLLIS T.reporter.nih.gov
Synthetic gene sensors and effectors to redirect organoid developmentNIHNational Institute of Biomedical Imaging and Bioengineering2021 to 2024$2,608,452May 1, 2021July 31, 2025WEISS, RONreporter.nih.gov
Pharmacologic Lysosomal Flux Activators to Ameliorate Alzheimer's Disease and Related DementiasNIHNational Institute on Aging2021$2,601,749September 1, 2021August 31, 2024KELLY, JEFFERY Wreporter.nih.gov
NATIONAL BIOREPOSITORY OF LUNG DISEASE-SPECIFIC HUMAN INDUCED PLURIPOTENT STEM CELLS:THE PURPOSE OF THIS RESOURCE IS TO BUILD AND SUPPORT A CRITICALNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,600,000May 1, 2020April 30, 2025N/A, N/Areporter.nih.gov
Probing the Cardiac PGC-1 Regulatory CascadeNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,593,540April 1, 1998March 31, 2025KELLY, DANIEL PATRICKreporter.nih.gov
Pediatric Heart Disease: Getting from Mutations to TherapeuticsNIHNational Heart, Lung, and Blood Institute2021 to 2023$2,582,324February 15, 2017January 31, 2025GELB, BRUCE Dreporter.nih.gov
Identifying cell type-specific autonomous and non-autonomous interactions in ADNIHNational Institute on Aging2022$2,567,371May 1, 2022April 30, 2025MENON, VILASreporter.nih.gov
Neuronal excitability and copy number variation disordersNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$2,563,265September 1, 2020May 31, 2026PENZES, PETERreporter.nih.gov
Cellular models of fetal neurodevelopment in maternal SARS-CoV-2 infectionNIHNational Institute of Mental Health2022$2,560,905September 15, 2022September 14, 2025EDLOW, ANDREA GOLDBERGreporter.nih.gov
Biomarker discovery for parkinsonian diseases in extracellular vesicles from iPSC-derived neuronsNIHNational Institute of Neurological Disorders and Stroke2023 to 2024$2,555,369April 1, 2023March 31, 2026BITAN, GALreporter.nih.gov
Three-dimensional conformation changes associated with T cell memory and autoimmunityNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2024$2,550,277September 15, 2020June 30, 2025HAWKINS, RAYMOND DAVIDreporter.nih.gov
A Human iPSC-Based Chimeric Mouse Model of Alzheimers Disease in Down SyndromeNIHNational Institute on Aging2021 to 2024$2,549,299September 30, 2021August 31, 2026JIANG, PENGreporter.nih.gov
Functional roles of lymphatics in organogenesis and tissue repairNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,543,362January 7, 2021December 31, 2025OLIVER, GUILLERMO Creporter.nih.gov
1/2 Cell Type and Region-Specific Regulatory Networks in Human Brain Development and DisordersNIHNational Institute of Mental Health2021 to 2022$2,541,620July 6, 2018March 31, 2024SESTAN, NENADreporter.nih.gov
Cellular and Molecular Analysis of the Psychiatric Risk Gene Transcription Factor 4 (TCF4)NIHNational Institute of Mental Health2021 to 2024$2,540,401September 2, 2016May 31, 2026MAHER, BRADY Jreporter.nih.gov
Investigating Pathogenic Mechanisms of Frontotemporal Dementia Caused by Mutations in CHMP2B and TBK1NIHNational Institute of Neurological Disorders and Stroke2021 to 2024$2,537,267January 1, 2018November 30, 2025GAO, FEN-BIAOreporter.nih.gov
Gaining insight into psychiatric disease by engineering piece by piece the human brain in vitro.NIHNational Institute of Mental Health2021 to 2024$2,536,379August 1, 2015May 31, 2025PASCA, SERGIUreporter.nih.gov
Improving transfusion therapy for patients with sickle cell disease with pluripotent stem cell-derived red cellsNIHNational Heart, Lung, and Blood Institute2021 to 2022$2,528,360September 15, 2016May 31, 2025CHOU, STELLA Treporter.nih.gov
Prenatal Origins of Neurometabolic ConsequencesNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2021 to 2024$2,517,422September 1, 2021July 31, 2026DEVASKAR, SHERIN Ureporter.nih.gov
Molecular and Cellular Dissection of the Pathogenesis of Herpes Simplex Encephalitis with iPSC-Derived CNS and PNS CellsNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$2,509,626September 20, 2010March 31, 2025CASANOVA, JEAN-LAURENTreporter.nih.gov
Editing Alveolar Progenitor Cells for Correction of Monogenic DiseaseNIHNational Heart, Lung, and Blood Institute2021 to 2022$2,504,499September 23, 2016May 31, 2025WHITSETT, JEFFREY Areporter.nih.gov
Single-cell dissection of chromatin architecture mechanisms connecting pathologic instability and transcriptional silencingNIHNational Institute on Drug Abuse2021 to 2024$2,498,183September 30, 2020August 31, 2025PHILLIPS-CREMINS, JENNIFER ELIZABETHreporter.nih.gov
Beyond Gene Dosage: Understanding Down Syndrome via 4D Genome OrganizationNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,496,816September 18, 2020August 31, 2025LI, WENBOreporter.nih.gov
Brain cPLA2 as a mechanism for neuroinflammation in AD/ADRD with and without APOE4 Diversity SupplementNIHNational Institute on Aging2022 to 2024$2,493,260May 15, 2022April 30, 2025YASSINE, HUSSEIN Nreporter.nih.gov
Defining the pathogenic relationship of TDP-43 inclusions and cytoplasmic double stranded RNA in AD and FTDNIHNational Institute on Aging2022$2,481,834August 2, 2022July 31, 2025ALBERS, MARK Wreporter.nih.gov
Developing a patient-specific organoid model of pulmonary fibrosis using iPSCsNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,476,283December 15, 2020November 30, 2025KOTTON, DARRELL N.reporter.nih.gov
Personalizing Class I anti-Arrhythmic Drug TherapyNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,473,840April 1, 2020March 31, 2026SILVA, JONATHAN Rreporter.nih.gov
HIV, Methamphetamine and Human iPSC-derived Microglia-containing Cerebral OrganoidsNIHNational Institute on Drug Abuse2021 to 2024$2,470,488July 1, 2020April 30, 2026HO, WENZHEreporter.nih.gov
Regulation of endothelial cell specificationNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,466,084February 15, 2021January 31, 2025PU, WILLIAM TSWENCHINGreporter.nih.gov
Identifying pathways required for integration of kidney organoid and host epitheliaNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2024$2,461,009September 1, 2020May 31, 2025DRUMMOND, IAIN A.reporter.nih.gov
Role of central and peripheral immune crosstalk in FTD-Grn neurodegenerationNIHNational Institute of Neurological Disorders and Stroke2022$2,446,942August 17, 2022July 30, 2025TANSEY, MARIA DE LOURDES GAMEZreporter.nih.gov
Higher Order Chromatin and Genetic Risk for SchizophreniaNIHNational Institute of Mental Health2021 to 2023$2,446,779January 15, 2015July 31, 2025AKBARIAN, SCHAHRAMreporter.nih.gov
Humanized Mouse Avatars for T1DNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2023$2,439,759September 25, 2014May 31, 2024GREINER, DALE LESLIEreporter.nih.gov
Cell-Type Specific Vulnerability to Tauopathy and Its Prevention in Multiple ModelsNIHNational Institute of Neurological Disorders and Stroke2021$2,438,130February 1, 2021January 31, 2024SIGURDSSON, EINAR Mreporter.nih.gov
Stem cells for therapeutics discovery in genetic blood disordersNIHNational Heart, Lung, and Blood Institute2021 to 2022$2,429,809September 23, 2016May 31, 2025DALEY, GEORGE Qreporter.nih.gov
Function of Putative Determinant in HematopoiesisNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2024$2,418,427August 1, 1993June 30, 2026BIEKER, JAMES Jreporter.nih.gov
Novel tools for in vitro electrophysiology and neurotrauma modelingNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$2,414,021August 17, 2020January 31, 2026FINAN, JOHN Dreporter.nih.gov
Gene regulatory networks for heart developmentNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,410,652January 1, 2021December 31, 2025BRUNEAU, BENOIT GAETANreporter.nih.gov
Alzheimer's disease-specific extracellular vesicles: from pathology to novel biomarker discoveryNIHNational Institute on Aging2023$2,399,582September 1, 2023August 31, 2026MACHAIRAKI, VASILIKIreporter.nih.gov
Alzheimer's Disease and Related Dementia-like Sequelae of SARS-CoV-2 Infection: Virus-Host Interactome, Neuropathobiology, and Drug RepurposingNIHNational Institute on Aging2023$2,394,473May 15, 2023April 30, 2026CHENG, FEIXIONGreporter.nih.gov
Epithelial stem/progenitor cells as repair agents in diffuse alveolar damageNIHNational Heart, Lung, and Blood Institute2021 to 2022$2,388,592September 21, 2016May 31, 2025CHAPMAN, HAROLD Areporter.nih.gov
Development of a Microphysiological Organ-on-Chip System to Model AmyotrophicNIHNational Institute of Neurological Disorders and Stroke2021 to 2022$2,385,538September 15, 2017February 28, 2024SVENDSEN, CLIVE NIELSreporter.nih.gov
Multi-organ-on-chip device for modeling opioid reinforcement and withdrawal, and the negative affective component of pain: a therapeutic screening tool.NIHNational Center for Advancing Translational Sciences2022 to 2024$2,380,820September 26, 2019July 31, 2025MAIDMENT, NIGEL Treporter.nih.gov
Discovering Wdfy3 as a novel regulator of macrophage efferocytosis by genome-wide CRISPR screenNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,375,761May 1, 2020April 30, 2026ZHANG, HANRUIreporter.nih.gov
Genome Wide Association Study for Childhood ObesityNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2021 to 2024$2,372,606July 15, 2008June 30, 2026GRANT, STRUAN F Areporter.nih.gov
Validation of an in vitro model of progressive fibrosis that mimics Idiopathic Pulmonary FibrosisNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,367,083February 15, 2021January 31, 2026GOMPERTS, BRIGITTE Nreporter.nih.gov
C9orf72 frontotemporal dementia (FTD) and amyotrophic lateral sclerosis(ALS): using patient cells and CRISPR to reveal therapeutic approachesNIHNational Institute on Aging2021 to 2022$2,365,559May 1, 2021April 30, 2024CONKLIN, BRUCE Rreporter.nih.gov
Synaptopathy and Pathogenesis in Frontotemporal Dementia: Role of CYLDNIHNational Institute on Aging2023$2,364,013June 1, 2023May 31, 2026YAO, WEI-DONGreporter.nih.gov
Regulation of HIV latency by microglial-neuronal interactionsNIHNational Institute on Drug Abuse2021 to 2023$2,363,459September 15, 2019July 31, 2025KARN, JONATHANreporter.nih.gov
Modeling the impact of regulatory and splicing variants on cellular function in Alzheimer's diseaseNIHNational Institute on Aging2021$2,360,820March 1, 2021February 29, 2024RAJ, TOWFIQUEreporter.nih.gov
Generation of four-chambered hearts through organoid fusionsNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,358,480September 1, 2024August 31, 2026LI, GUANGreporter.nih.gov
Integrated Microphysiological System of Cerebral Organoid and Blood Vessel for Disease Modeling and Neuropsychiatric Drug screeningNIHNational Center for Advancing Translational Sciences2021 to 2022$2,355,934February 15, 2018January 31, 2025LEONG, KAM Wreporter.nih.gov
Investigating the molecular mechanisms of HIV/AIDS associated neurological disorders using microglia and cerebral organoids derived from induced pluripotent stem cellsNIHNational Institute on Drug Abuse2021 to 2023$2,348,133September 1, 2019July 31, 2025RANA, TARIQ Mreporter.nih.gov
Dark GPCR signaling underlying the Microbiome-Gut-Brain Axis for Alzheimer's Disease and Related DementiaNIHNational Institute of Neurological Disorders and Stroke2023$2,344,291August 18, 2023July 31, 2026CHENG, FEIXIONGreporter.nih.gov
Targeting the genotype to phenotype link in HCM as a therapeutic strategyNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,339,175March 1, 2021February 28, 2026MERCOLA, MARKreporter.nih.gov
Developmental Origin, Injury and Epigenomic Regulation of NF1-Associated Peripheral Nerve Sheath TumorsNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$2,339,120April 15, 2021June 30, 2024ZHU, YUANreporter.nih.gov
2/7-Collaborative genomic studies of Tourette DisorderNIHNational Institute of Mental Health2021 to 2022$2,333,736July 27, 2018September 30, 2023STATE, MATTHEW W.reporter.nih.gov
Integrated Cellular and Tissue Engineering for Ischemic Heart DiseaseNIHNational Heart, Lung, and Blood Institute2021 to 2022$2,333,316September 15, 2016May 31, 2025ZHANG, JIANYIreporter.nih.gov
Determining the mechanism of IFIH1 disease-associated variants on beta-cell and immune responses in Type 1 diabetesNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2022$2,332,346September 15, 2020December 31, 2022TSE, HUBERT Mreporter.nih.gov
Targeting Aging to prevent Alzheimer's Disease: the Geroscience ApproachNIHNational Institute on Aging2021 to 2024$2,327,496April 15, 2020September 30, 2025LITHGOW, GORDON Jreporter.nih.gov
Nextgen AD Models, Endotypes, and ScreeningNIHNational Institute on Aging2024$2,319,456June 1, 2024May 31, 2027SUBRAMANIAM, SHANKARreporter.nih.gov
Novel roles for p27 as transcriptional co-regulator of cJun in stem cells and developmentNIHNational Cancer Institute2021 to 2024$2,319,039September 1, 2020August 31, 2025SLINGERLAND, JOYCE MARIEreporter.nih.gov
Cell-type-specific NRXN1alpha alternative splicing changes in psychiatric diseaseNIHNational Institute of Mental Health2021 to 2023$2,314,430July 18, 2019April 30, 2025FANG, GANGreporter.nih.gov
Transplantation of MHC Homozygous Vascular Progenitors in PrimatesNIHNational Heart, Lung, and Blood Institute2021 to 2022$2,302,970September 20, 2016May 31, 2025SLUKVIN, IGOR I.reporter.nih.gov
Joint Pain on a Chip: Mechanistic Analysis Therapeutic Targets and an Empirical Strategy for Personalized Pain ManagementNIHNational Center for Advancing Translational Sciences2021$2,287,391September 26, 2019July 31, 2025GOLD, MICHAEL Sreporter.nih.gov
ApoE, lipid and immune mechanisms of human neurons and gliaNIHNational Institute on Aging2023$2,284,296December 15, 2022November 30, 2025ISACSON, OLEreporter.nih.gov
Uncovering treatment targets for peripheral nerve sheath tumor progression in NF1NIHNational Institute of Neurological Disorders and Stroke2021 to 2024$2,281,119September 1, 2020June 30, 2025LARGAESPADA, DAVID ANDREWreporter.nih.gov
Determining the Intrinsic and Environmental Signal Contributing to Early T1D ProgressionNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2023$2,260,661September 15, 2020June 30, 2025CHEN, SHUIBINGreporter.nih.gov
Loss of TDP-43 disrupts the prefrontal neural activity and circuitry: relevance for TDP-43 linked ADRDNIHNational Institute of Neurological Disorders and Stroke2022$2,255,378September 19, 2022August 31, 2025LI, YUNreporter.nih.gov
Functional Genomics of Tibetan AdaptationsNIHNational Heart, Lung, and Blood Institute2021 to 2023$2,246,453April 1, 2014June 30, 2025DI RIENZO, ANNAreporter.nih.gov
Functional Validation of TDP-43 splicing repression for frontotemporal degenerationNIHNational Institute of Neurological Disorders and Stroke2021 to 2022$2,237,856September 1, 2021August 31, 2023WONG, PHILIP Creporter.nih.gov
PCTC Administrative Coordinating CenterNIHNational Heart, Lung, and Blood Institute2021 to 2022$2,233,284September 20, 2016May 31, 2025TERRIN, MICHAEL Lreporter.nih.gov
Genetic Regulation of Nonalcoholic Fatty Liver DiseaseNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2024$2,221,739June 8, 2021March 31, 2026MEDINA, MARISA WONGreporter.nih.gov
Development of a Synthetic, Cell-Permeable Peptide for the Inhibition of CDK5-p25 Hyperactivity in Amyotrophic Lateral SclerosisNIHNational Institute of Neurological Disorders and Stroke2021 to 2022$2,210,678September 22, 2021August 31, 2024WERNER, JOHN KENTreporter.nih.gov
Development of Brain Organoids to Study the Impact of HIV-1, Drugs of Abuse and Aging on Cognitive ImpairmentNIHNational Institute on Drug Abuse2021 to 2024$2,208,551July 15, 2020May 2, 2024NIXON, DOUGLAS Freporter.nih.gov
Cell autonomous and non-cell autonomous phenotypes due to genetic risk for late onset Alzheimers diseaseNIHNational Institute on Aging2021$2,207,391May 1, 2021April 30, 2024POON, WAYNE Wreporter.nih.gov
Mechanisms of epithelial repair and remodeling in pulmonary fibrosisNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,193,295July 15, 2020June 30, 2025KROPSKI, JONATHAN ANDREWreporter.nih.gov
A Novel Role for NFATC1 in Modulating Cardiac ExcitabilityNIHNational Heart, Lung, and Blood Institute2021 to 2023$2,192,974July 1, 2020June 30, 2025TRISTANI-FIROUZI, MARTINreporter.nih.gov
Molecular Segregation of Parkinson’s Disease by Patient-Derived NeuronsNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$2,183,720June 1, 2020May 31, 2026FENG, JIANreporter.nih.gov
Mechanisms of gene regulation and RNA processing in synucleinopathiesNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$2,181,405July 1, 2020June 30, 2025MAZZULLI, JOSEPH Rreporter.nih.gov
Novel patient-derived 3D platform for detecting TDP-43 proteinopathy and associated biomarkers for ALS/FTDNIHNational Institute of Neurological Disorders and Stroke2022 to 2023$2,175,360February 15, 2022January 31, 2025GHAFFARI, LAYLAreporter.nih.gov
Resilience to Alzheimer's disease by targeting adult hippocampal neurogenesisNIHNational Institute on Aging2024$2,173,794September 1, 2024August 31, 2027CHOI, SE HOONreporter.nih.gov
A microphysiological system of tendon inflammation and fibrosis for drug screening and efficacy testingNIHNational Center for Advancing Translational Sciences2022 to 2024$2,172,600August 15, 2020July 31, 2025AWAD, HANI Areporter.nih.gov
Sox Proteins Modulate Genomic Specificity of B-catenin Regulated Transcription in the Developing GutNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2024$2,163,911January 15, 2021December 31, 2025ZORN, AARON Mreporter.nih.gov
The µSiM-hNVU - a human BBB platform for the study of brain injury mechanisms during systemic infectionNIHNational Heart, Lung, and Blood Institute2022 to 2024$2,162,325September 3, 2020August 31, 2025MCGRATH, JAMES Lreporter.nih.gov
Neurotoxicity of particulate matter and its interaction with APOE in neurodegenerationNIHNational Institute of Neurological Disorders and Stroke2022$2,159,148September 20, 2022August 31, 2025KITAZAWA, MASASHIreporter.nih.gov
Role of SCN1B in Inherited EpilepsyNIHNational Institute of Neurological Disorders and Stroke2021 to 2023$2,149,827February 1, 2011January 31, 2025ISOM, LORI L.reporter.nih.gov
Readily Available Stem Cell-Based Vascular Grafts for Emergent Surgical CareNIHNational Heart, Lung, and Blood Institute2021 to 2023$2,141,117July 1, 2020June 30, 2025QYANG, YIBINGreporter.nih.gov
Methylglyoxal drives astrocyte senescence to mediate neurodegeneration in Alzheimer's diseaseNIHNational Institute on Aging2021 to 2024$2,135,509August 1, 2020July 31, 2025KAPAHI, PANKAJreporter.nih.gov
Toward Understanding the Role of the Polycomb Complex in Skin ControlNIHNational Institute of Arthritis and Musculoskeletal and Skin Diseases2021 to 2024$2,130,652February 1, 2016August 31, 2025EZHKOVA, ELENAreporter.nih.gov
Manganese exposure susceptibility as a modifier of excitotoxicity in Alzheimer's DiseaseNIHNational Institute of Environmental Health Sciences2021 to 2024$2,124,884February 1, 2020October 31, 2025HARRISON, FIONA EDITHreporter.nih.gov
Development of CRISPR/Cas9-based exon-skipping strategies for the treatment of USH-associated deafnessNIHNational Institute on Deafness and Other Communication Disorders2022 to 2024$2,113,099August 22, 2022June 30, 2027LIU, XUE Zreporter.nih.gov
Modeling Alzheimer's disease genetic variants in hiPSCNIHNational Institute on Aging2021 to 2023$2,102,361May 1, 2019February 28, 2025DUAN, JUBAOreporter.nih.gov
Genetic Regulation of Inner, Middle and Outer Ear DevelopmentNIHNational Institute on Deafness and Other Communication Disorders2021 to 2024$2,101,738March 22, 2013November 30, 2025GROVES, ANDREW Kreporter.nih.gov
Cardiac Mechanisms of Sudden Unexpected Death in EpilepsyNIHNational Heart, Lung, and Blood Institute2021 to 2023$2,101,543July 1, 2020June 30, 2025ISOM, LORI L.reporter.nih.gov
Targeting Dyrk1a to Promote Donor-independent Platelet ProductionNIHNational Heart, Lung, and Blood Institute2021 to 2023$2,097,567February 20, 2020January 31, 2025GOLDFARB, ADAM N.reporter.nih.gov
Mini-Livers Derived from Human IPS Cells for Modeling Steatosis and TherapyNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2024$2,096,374August 1, 2014May 31, 2025SOTO-GUTIERREZ, ALEJANDROreporter.nih.gov
Mechanisms and Regulation of Brain Iron UptakeNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$2,095,116December 1, 2019November 30, 2025CONNOR, JAMES ROBERTreporter.nih.gov
Cell Type and Regional Vulnerability in Frontotemporal DementiaNIHNational Institute of Neurological Disorders and Stroke2021$2,094,351August 1, 2021July 31, 2024TEMPLE, SALLYreporter.nih.gov
Understanding Frontotemporal Dementia Using Drosophila and iPSC ModelsNIHNational Institute of Neurological Disorders and Stroke2022$2,086,468April 15, 2017March 31, 2025GAO, FEN-BIAOreporter.nih.gov
Modeling CNS dynamics in HIV infection and cannabinoids with forebrain organoidsNIHNational Institute on Drug Abuse2021 to 2023$2,085,642August 1, 2019June 30, 2025JORDAN-SCIUTTO, KELLY Lreporter.nih.gov
Resolving the Role of Neuronal STING in Amyotrophic Lateral Sclerosis and Frontotemporal DementiaNIHNational Institute of Neurological Disorders and Stroke2023$2,085,362January 5, 2023December 31, 2025WAINGER, BRIAN JASONreporter.nih.gov
Interplay between AMPK and Hippo Signaling Regulates Ocular Antiviral Response to Zika virus infectionNIHNational Eye Institute2021 to 2024$2,079,783January 1, 2021December 31, 2025ARUMUGASWAMI, VAITHILINGARAJAreporter.nih.gov
Connecting 3D genome misfolding to transcriptional silencing in fragile X syndromeNIHNational Institute of Mental Health2021 to 2024$2,066,257August 15, 2019January 31, 2029PHILLIPS-CREMINS, JENNIFER ELIZABETHreporter.nih.gov
Neuronal ABCA7 loss of function and Alzheimer’s diseaseNIHNational Institute on Aging2023$2,063,098June 1, 2023May 31, 2026KANEKIYO, TAKAHISAreporter.nih.gov
The Role of PRDM16 in Cardiac Development and CardiomyopathyNIHNational Heart, Lung, and Blood Institute2021 to 2023$2,054,619July 15, 2020May 31, 2025BOUDINA, SIHEMreporter.nih.gov
Bone marrow-targeted extracellular vesicles as a novel non-viral gene editor delivery platformNIHNational Center for Advancing Translational Sciences2022 to 2023$2,051,588July 1, 2022May 31, 2025THON, JONATHAN Nreporter.nih.gov
Cancer patient on a chipNIHNational Cancer Institute2021 to 2024$2,041,238July 15, 2020June 30, 2025VUNJAK-NOVAKOVIC, GORDANAreporter.nih.gov
Neuronal quality control and neuroprotection in tauopathiesNIHNational Institute on Aging2021 to 2024$2,040,301August 1, 2007April 30, 2026CHU, CHARLEEN Treporter.nih.gov
Aortic Valve Disease: Mechanisms and Therapeutic ApproachesNIHNational Heart, Lung, and Blood Institute2021 to 2023$2,037,372February 10, 2020January 31, 2025SRIVASTAVA, DEEPAKreporter.nih.gov
Structure function relationships from deep mutational scanning in human cardiomyopathyNIHNational Heart, Lung, and Blood Institute2021 to 2023$2,035,543January 1, 2020December 31, 2024ASHLEY, EUAN Areporter.nih.gov
Investigating epigenetic mechanisms in Down syndrome using human cellular modelsNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2023$2,034,753April 5, 2023March 31, 2026BARRETT, LINDY ELISEreporter.nih.gov
Predictive assessment of acute and chronic cardiotoxicity using combinatorially matured hPSC-CMsNIHNational Heart, Lung, and Blood Institute2021 to 2023$2,034,388December 1, 2022August 31, 2024GEISSE, NICHOLAS ANDREWreporter.nih.gov
Dissecting the role of tau glycosylation in Alzheimer's diseaseNIHNational Institute on Aging2023$2,031,054April 15, 2023March 31, 2026WALCZAK, MACIEJreporter.nih.gov
Functional implications of CPVT1-associated RyR2 mutations in human cardiomyocytesNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,028,489September 1, 2021July 31, 2026MORAD, MARTINreporter.nih.gov
Functional analysis of mammalian midbody RNA in post-mitotic signaling functionsNIHNational Institute of General Medical Sciences2021 to 2024$2,023,221September 16, 2021August 31, 2025SKOP, AHNA RENEEreporter.nih.gov
A stress-induced promoter pause release program in cardiomyocytes protecting against myocardial infarctionNIHNational Heart, Lung, and Blood Institute2021 to 2023$2,021,907December 15, 2019November 30, 2024ROSENFELD, MICHAEL Greporter.nih.gov
Genetic Analysis of MicroRNA Functions in Skin Stem Cells In VivoNIHNational Institute of Arthritis and Musculoskeletal and Skin Diseases2021 to 2024$2,013,300July 1, 2014November 30, 2025YI, RUIreporter.nih.gov
iPSC-derived Neurovascular OrganoidsNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$2,012,834April 15, 2020March 31, 2026LIPPMANN, ETHANreporter.nih.gov
Genome Editing of Human iPSCs to Study Inherited Hypertrophic CardiomyopathyNIHNational Heart, Lung, and Blood Institute2021 to 2022$2,008,113March 10, 2015June 30, 2024WU, JOSEPH C.reporter.nih.gov
The role of APP in neurogenesis and AD in Down syndromeNIHNational Institute on Aging2022$2,005,131September 15, 2022August 31, 2025LAZAROV, ORLYreporter.nih.gov
Rab GTPases-mediated mitochondrial clearance in diabetic cardiomyopathyNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,003,229April 1, 2020March 31, 2026ONG, SANG GINGreporter.nih.gov
Psychosis-related Physiological and Neuronal Phenotypes in 22q11 Deletion SyndromeNIHNational Institute of Mental Health2021 to 2023$1,997,858September 1, 2019September 30, 2024CUBELLS, JOSEPH F.reporter.nih.gov
Generation of human skin organoids from pluripotency (Admin Supplement)NIHNational Institute of Arthritis and Musculoskeletal and Skin Diseases2021 to 2023$1,996,696September 17, 2019August 31, 2025KOEHLER, KARL RUSSELLreporter.nih.gov
Role of Siglec-1 in HIV Interactions with Microglia and AstrocytesNIHNational Institute on Drug Abuse2021 to 2024$1,981,204July 15, 2020April 30, 2026SPEARMAN, PAUL W.reporter.nih.gov
Human Microphysiological Model of Afferent Nociceptive SignalingNIHNational Center for Advancing Translational Sciences2021$1,978,863September 26, 2019January 31, 2025MOORE, MICHAEL Jreporter.nih.gov
Genomic Effects on Right Ventricular Function, Clinical Features and Outcomes in CHDNIHNational Heart, Lung, and Blood Institute2021 to 2024$1,948,211September 30, 2009July 31, 2025NEWBURGER, JANE W.reporter.nih.gov
Define the effect of CLU SNP on the risk to Alzheimer's diseaseNIHNational Institute on Aging2022$1,942,962August 1, 2022July 31, 2025SHI, YANHONGreporter.nih.gov
A Novel Approach to Molecular Cell Pathologies of Human Down Syndrome and DS-ADNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2021 to 2023$1,938,999September 12, 2017March 31, 2026LAWRENCE, JEANNE BENTLEYreporter.nih.gov
Human iPSC model of Cerebro-Vascular Interactions in ADRDNIHNational Institute of Neurological Disorders and Stroke2024$1,931,965August 15, 2024July 31, 2027TEMPLE, SALLYreporter.nih.gov
Rare Variant Whole Genome Analysis and iPSC Validation of Putative Genetic Modifiers of Huntington DiseaseNIHNational Institute of Neurological Disorders and Stroke2021 to 2023$1,931,388April 1, 2017March 31, 2024FINKBEINER, STEVEN Mreporter.nih.gov
Derivation of Functional Spermatogonia Stem Cells from Rhesus Macaque iPSCsNIHOffice of the Director, National Institutes of Health2021 to 2022$1,921,633September 9, 2019June 30, 2024EASLEY, CHARLES A.reporter.nih.gov
Construction of the integrated human cortical organoids to investigate neurodevelopmental disordersNIHNational Institute of Mental Health2021 to 2023$1,916,931September 9, 2019July 31, 2025PARK, IN-HYUNreporter.nih.gov
The hCNS-HIV/ARV assay system, a platform utilizing human iPSC-neurons/-microglia/-astrocytes to test HIV/AIDS therapeutics for neurotoxicity related to HIV-associated cognitive disroder (HAND)NIHNational Institute of Mental Health2021 to 2022$1,916,189September 10, 2018April 30, 2024MCDONOUGH, PATRICK Mreporter.nih.gov
Human iPSC-derived atrial cardiomyocytes to model atrial fibrillation in a dishNIHNational Heart, Lung, and Blood Institute2021 to 2023$1,914,578January 17, 2020December 31, 2024DARBAR, DAWOODreporter.nih.gov
Assessing the effects of peripheral immune activation on the NVU following TBI using avascularized and perfused human blood/BBB model.NIHNational Heart, Lung, and Blood Institute2021 to 2022$1,914,338September 15, 2021August 31, 2023AGALLIU, DRITANreporter.nih.gov
Functional Studies of Novel Genes Mutated in Primary Ciliary Dyskinesia II: Genotype to PhenotypeNIHNational Heart, Lung, and Blood Institute2021 to 2023$1,901,730August 15, 2013February 28, 2025OSTROWSKI, LAWRENCE Ereporter.nih.gov
Modulating microglial function to restore A-beta proteostasis in Alzheimer's DiseaseNIHNational Institute on Aging2021$1,894,783September 30, 2021August 31, 2024TOURTELLOTTE, WARREN Greporter.nih.gov
UNDERSTANDING HEPATIC PROTEOSTASIS IN SYSTEMIC AMYLOID DISEASESNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2023$1,891,335July 14, 2020March 31, 2024WISEMAN, ROCKLAND LUKEreporter.nih.gov
A 2D Intestinal Crypt Platform for Compound ScreensNIHNational Institute of Diabetes and Digestive and Kidney Diseases2022 to 2023$1,888,698July 1, 2021July 31, 2025SIMS, CHRISTOPHER ELDRIDGEreporter.nih.gov
Optimized Ratiometric Voltage-Sensitive Dyes for Cardiac Research, Safety PharmacologyNIHNational Institute of General Medical Sciences2023 to 2024$1,888,402September 8, 2023August 31, 2025ACKER, COREYreporter.nih.gov
Optimization of the engineered 3D hepatic microenvironment enhances pluripotent stem cell derived hepatocyteNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2024$1,887,016February 1, 2020January 31, 2026SCHWARTZ, ROBERT Ereporter.nih.gov
Genomic Studies in Charcot-Marie-Tooth DiseaseNIHNational Institute of Neurological Disorders and Stroke2021 to 2023$1,886,243September 15, 2019July 31, 2025ZUCHNER, STEPHANreporter.nih.gov
Microenvironmental Control of Liver Progenitor Cell Differentiation and Spatial PatterningNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2024$1,882,996April 15, 2021March 31, 2026UNDERHILL, GREGORY Hreporter.nih.gov
Effects of HSV-1 infection on neural progenitor cell biology in vitro and in vivoNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$1,871,397July 1, 2020April 30, 2026D'AIUTO, LEONARDOreporter.nih.gov
CGG repeat associated translation in Fragile X-associated Tremor/Ataxia SyndromeNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$1,869,734April 1, 2014December 31, 2025TODD, PETER Kreporter.nih.gov
3-Dimensional Retinal Organoid Platform for the Study of RetinoblastomaNIHNational Cancer Institute2021 to 2024$1,863,510September 15, 2020June 30, 2025PELAEZ, DANIELreporter.nih.gov
Neuronal roles of Parkinsons Disease Vps13C in regulating autophagy and calcium dynamicsNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$1,856,046September 30, 2020January 31, 2026CARAVEOPISO, GABRIELAreporter.nih.gov
Identifying the role of notch3 in brain pericyte function in health and Alzheimer's diseaseNIHNational Institute of Neurological Disorders and Stroke2023$1,838,781April 15, 2023March 31, 2026SHUSTA, ERIC Vreporter.nih.gov
Patient-derived Models of Synaptic Pruning in SchizophreniaNIHNational Institute of Mental Health2021 to 2023$1,832,595July 19, 2019April 30, 2025PERLIS, ROY H.reporter.nih.gov
Planar culture of gastrointestinal stem cells for screening pharmaceuticals for adverse event riskNIHNational Center for Advancing Translational Sciences2023 to 2024$1,827,318July 1, 2023June 30, 2025SIMS, CHRISTOPHER ELDRIDGEreporter.nih.gov
Validation of Novel Pathogenic Post-Translational Modifications of Huntingtin, and of Modifying Enzymes as Therapeutic Targets for Huntington's DiseaseNIHNational Institute of Neurological Disorders and Stroke2021 to 2023$1,815,246April 1, 2014January 31, 2025ROSS, CHRISTOPHER Areporter.nih.gov
Molecular dissection of synaptic dysfunction in mental disordersNIHNational Institute of Mental Health2021 to 2024$1,815,127April 1, 2020January 31, 2026PAK, CHANGHUIreporter.nih.gov
Targeting Tau Proteoforms in Frontotemporal DementiaNIHNational Institute of Neurological Disorders and Stroke2021$1,815,043August 1, 2021July 31, 2024KARCH, CELESTE MARIEreporter.nih.gov
Towards a preclinical model for overcoming infertility with induced pluripotent stem cellsNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2021 to 2023$1,802,832June 1, 2019May 31, 2025CLARK, AMANDERreporter.nih.gov
Modeling Frontotemporal Dementia in Rhesus MacaquesNIHNational Institute of Neurological Disorders and Stroke2022 to 2024$1,789,771September 30, 2019May 31, 2026EMBORG, MARINAreporter.nih.gov
2/2 Discovery and validation of neuronal enhancers associated with the development of psychiatric disordersNIHNational Institute of Mental Health2021 to 2022$1,780,670August 17, 2018April 30, 2025GESCHWIND, DANIEL Hreporter.nih.gov
Integrating epigenomics with DNA breathing dynamics for human non-coding disease variantsNIHNational Institute of Mental Health2021 to 2023$1,777,464April 8, 2019January 31, 2025DUAN, JUBAOreporter.nih.gov
TAOK2 Kinase Signaling in Human Neural Stem Cell DevelopmentNIHNational Institute of Mental Health2021 to 2024$1,777,371December 2, 2019November 30, 2025YADAV, SMITAreporter.nih.gov
Resilience pathways modeling human longevity-promoting ApoE variants in induced pluripotent stem cellsNIHNational Institute on Aging2021 to 2022$1,759,184September 30, 2018May 31, 2025ELLERBY, LISA Mreporter.nih.gov
Use of iPSC systems to define roles of microglial TREM2/DAP12 and CR3/DAP12 complexes and their genetic variants in specifying risk for late onset sporadic Alzheimer's diseaseNIHNational Institute on Aging2021 to 2022$1,754,492September 30, 2018April 30, 2025FOSSATI, VALENTINAreporter.nih.gov
Study of melanocyte lineage through SASH1 and associated proteinsNIHNational Institute of Arthritis and Musculoskeletal and Skin Diseases2021 to 2024$1,751,055April 13, 2020March 31, 2026SHELLMAN, YIQUN Greporter.nih.gov
Kindlin-3 signaling in plateletsNIHNational Heart, Lung, and Blood Institute2022 to 2024$1,742,425February 10, 2022January 31, 2026MA, YAN-QINGreporter.nih.gov
REGULATION OF SKELETAL MUSCLE DEVELOPMENT AND MAINTENANCE BY PROTEIN O-GLUCOSYLTRANSFERASE 1 (POGLUT1)NIHNational Institute of Arthritis and Musculoskeletal and Skin Diseases2021 to 2024$1,740,283July 8, 2020June 30, 2025JAFAR-NEJAD, HAMEDreporter.nih.gov
Using hiPSCs to develop physiologically-relevant outer retina tissue mimeticsNIHNational Eye Institute2022 to 2024$1,738,353September 30, 2022August 31, 2025SINGH, RUCHIRAreporter.nih.gov
Molecular underpinnings of Prader-Willi syndromeNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2021 to 2023$1,733,926September 9, 2019June 30, 2025CARMICHAEL, GORDON Greporter.nih.gov
Novel Regulation and Function of the lncRNA Gomafu in Human NeuronsNIHNational Institute of Neurological Disorders and Stroke2021 to 2023$1,731,019July 15, 2019May 31, 2025FENG, YUEreporter.nih.gov
Multi-Scale In Vitro 3D Tissue Model of Vascularized Bone-Cartilage InteractionsNIHNational Institute of Arthritis and Musculoskeletal and Skin Diseases2021 to 2022$1,730,750September 21, 2017August 31, 2024ROEHM, KEVINreporter.nih.gov
Genome-wide mapping and integrative analysis of DNA 6mA methylome in human AD brainNIHNational Institute on Aging2021 to 2023$1,730,272September 1, 2019January 6, 2025ZHAO, JINYINGreporter.nih.gov
Human Disease-Specific Induced Pluripotent Stem Cells For Preclinical Drug Testing and Drug DiscoveryNIHNational Heart, Lung, and Blood Institute2022$1,728,439March 4, 2022February 28, 2023BUI, LYNNE Areporter.nih.gov
ANKS1B haploinsufficiency in a novel brain disorderNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$1,727,744September 15, 2020August 31, 2025JORDAN, BRYEN ALEXANDERreporter.nih.gov
Rescue of Lesch-Nyhan DiseaseNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$1,719,066September 1, 2021June 30, 2026JINNAH, HYDER Areporter.nih.gov
Functional consequences of FHC mutations in cardiac MyBPCNIHNational Heart, Lung, and Blood Institute2021 to 2023$1,718,806February 1, 2013March 31, 2025STELZER, JULIANreporter.nih.gov
Hydrogel-enabled self-assembled human brain organoids for neurotoxicity applicationsNIHNational Institute of Environmental Health Sciences2021 to 2022$1,713,966May 15, 2019February 29, 2024LEBAKKEN, CONNIE Sreporter.nih.gov
Functional analysis of autism risk genes during neural development using single cell seqNIHNational Institute of Mental Health2021 to 2023$1,710,471March 15, 2019January 31, 2025GIRALDEZ, ANTONIO Jreporter.nih.gov
Mechanisms of tau- and aging-induced neurological dysfunction: Focus on the nucleusNIHNational Institute on Aging2021 to 2023$1,709,738February 15, 2019November 30, 2024FROST, BESSreporter.nih.gov
Therapeutic Development of Osteogenic Oxysterol, Oxy133, for Spine FusionNIHNational Institute of Arthritis and Musculoskeletal and Skin Diseases2021 to 2022$1,707,540September 1, 2021August 31, 2024PARHAMI, FARHADreporter.nih.gov
Synergistic Enhancement of ER proteostasis, trafficking, and lysosomes as treatments for Dementia with Lewy bodies and Parkinson’s disease-dementiaNIHNational Institute of Neurological Disorders and Stroke2024$1,707,089August 15, 2024July 31, 2027MAZZULLI, JOSEPH Rreporter.nih.gov
Embryonic natural killer cell development and functionNIHNational Heart, Lung, and Blood Institute2021 to 2023$1,702,824May 1, 2021April 30, 2025STURGEON, CHRISTOPHER MICHAELreporter.nih.gov
Determining stathmin-2 function and potential as a therapeutic target in ALS/FTDNIHNational Institute of Neurological Disorders and Stroke2023 to 2024$1,692,971April 1, 2020March 31, 2025CLEVELAND, DON Wreporter.nih.gov
Development and Evaluation of Rosette Array Technology for HumanNeurodevelopmental Toxicity ScreeningNIHNational Institute of Environmental Health Sciences2022 to 2023$1,683,587January 1, 2022December 31, 2024ASHTON, RANDOLPH SCOTTreporter.nih.gov
Regulation and function of hematopoietic stem cell nichesNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2023$1,682,486March 1, 2000December 31, 2024GRITSMAN, KIRAreporter.nih.gov
Defining the Mechanisms by Which MS4A Genes Regulate TREM2 in Alzheimer DiseaseNIHNational Institute on Aging2021 to 2023$1,679,487September 1, 2019May 31, 2025KARCH, CELESTE MARIEreporter.nih.gov
Development of HLA engineered universal vascular grafts from human iPSCsNIHNational Heart, Lung, and Blood Institute2021 to 2024$1,675,000August 1, 2021July 31, 2025QYANG, YIBINGreporter.nih.gov
Functional Validation of Gene Modifications that Protect Beta Cells against Autoimmunity Identified by Genome-Wide CRISPR Cas9 ScreeningNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2024$1,673,100September 30, 2018February 28, 2025YI, PENGreporter.nih.gov
Understanding Down Syndrome Brain Development Using Human iPSC-Based Mouse ChimerasNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$1,671,510March 1, 2021December 31, 2026JIANG, PENGreporter.nih.gov
Impact of coding and non-coding variation in progressive supranuclear palsyNIHNational Institute of Neurological Disorders and Stroke2021$1,664,308September 25, 2017July 31, 2023GESCHWIND, DANIEL Hreporter.nih.gov
Nucleus Accumbens-Associated Protein-1 in Melanoma ImmunotherapyNIHNational Cancer Institute2021 to 2023$1,663,168July 3, 2018November 30, 2024YANG, JIN-MINGreporter.nih.gov
Stem cell-loaded microgels to treat discogenic low back painNIHNational Institute of Neurological Disorders and Stroke2021$1,655,677September 27, 2021August 31, 2024SHEYN, DMITRIYreporter.nih.gov
Protective role of Neuregulin-1 against cerebral malaria-induced neuronal injury and behavioral sequelaeNIHNational Institute of Neurological Disorders and Stroke2022 to 2024$1,644,196January 1, 2022December 31, 2027STILES, JONATHAN K.reporter.nih.gov
Biomechanical Activation of Yap Induces Hematopoietic Stem Cell ProductionNIHNational Heart, Lung, and Blood Institute2021 to 2023$1,632,318April 1, 2020March 31, 2026NORTH, TRISTA E.reporter.nih.gov
A phenotypic screen for compounds that differentially affect excitatory and inhibitory neuronal signalingNIHNational Institute of Mental Health2022 to 2023$1,630,701August 8, 2019October 31, 2024RYAN, STEVEN JOHNreporter.nih.gov
Control of cardiomyocyte cell cycle by REST in heart failure and regenerationNIHNational Heart, Lung, and Blood Institute2021 to 2023$1,630,521July 15, 2020September 30, 2023ZHOU, BINreporter.nih.gov
Epigenetic Pathology and Therapy in Huntington's DiseaseNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$1,621,733April 1, 2015May 31, 2025FRAENKEL, ERNESTreporter.nih.gov
Structure-guided and high-throughput engineering of genetically encoded sensors for reactive oxygen speciesNIHNational Institute of General Medical Sciences2021 to 2024$1,614,963February 1, 2021January 31, 2026BERNDT, ANDREreporter.nih.gov
A multi-modular approach for human pluripotent stem cell-based liver regenerationNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2023$1,608,063September 15, 2020July 31, 2025GOUON-EVANS, VALERIE Breporter.nih.gov
Identifying the origins of resilience through human single cell molecular networks, then testing them in diverse, resilient, human IPS linesNIHNational Institute on Aging2022 to 2023$1,607,217September 30, 2018May 31, 2025GAITERI, CHRISTOPHER A.reporter.nih.gov
Developmental Activation of the Inflammasome Controls Hematopoietic Stem Cell ProductionNIHNational Heart, Lung, and Blood Institute2021 to 2023$1,599,382August 1, 2020July 31, 2025NORTH, TRISTA E.reporter.nih.gov
Determining stathmin-2 function and potential as a therapeutic target in ALS/FTDNIHNational Institute of Neurological Disorders and Stroke2021 to 2022$1,595,758April 1, 2020March 31, 2025CLEVELAND, DON Wreporter.nih.gov
Mechanotransduction by Melusin in Cardiac HypertrophyNIHNational Heart, Lung, and Blood Institute2021 to 2023$1,594,551July 1, 2020June 30, 2025SNIADECKI, NATHAN JOHNreporter.nih.gov
Phosphoinositide signaling in glaucoma: rescue strategies for Lowe syndromeNIHNational Eye Institute2021 to 2024$1,593,733June 1, 2021May 31, 2025SUN, YANGreporter.nih.gov
Apolipoprotein E glycosylation and its role in Alzheimer's disease pathogenesisNIHNational Institute on Aging2021 to 2023$1,593,459April 1, 2021June 30, 2023FLOWERS, SARAH ANNreporter.nih.gov
Identifying the origins of resilience through human single cell molecular networks, then testing them in diverse, resilient, human IPS linesNIHNational Institute on Aging2021 to 2022$1,590,436September 30, 2018August 31, 2022GAITERI, CHRISTOPHER A.reporter.nih.gov
Precision models of ARX-associated neurodevelopmental disordersNIHNational Institute of Neurological Disorders and Stroke2021 to 2023$1,588,474June 1, 2019May 31, 2025HSIEH, JENNYreporter.nih.gov
Editing CG and non-CG DNA methylation to identify genomic elements that regulate gene expressionNIHNational Human Genome Research Institute2021 to 2024$1,588,081September 10, 2021June 30, 2025GOODARZI, HANIreporter.nih.gov
The Role of 3-Dimensional Genome Integrity In Cardiac LaminopathiesNIHNational Heart, Lung, and Blood Institute2021 to 2023$1,585,451August 1, 2020May 31, 2025KARAKIKES, IOANNISreporter.nih.gov
Cellular and Molecular Mechanisms of Brain Dysfunction in NF1NIHNational Institute of Neurological Disorders and Stroke2021 to 2024$1,581,350April 15, 2020January 31, 2025YANG, NANreporter.nih.gov
Identification of Genetic and Molecular Bases of Derived Phenotypes in Primate Brain DevelopmentNIHNational Human Genome Research Institute2021 to 2023$1,574,253May 16, 2023June 30, 2024SESTAN, NENADreporter.nih.gov
Dynamic Biomaterial Design to Probe the Cellular Response to Fibrotic StiffeningNIHNational Heart, Lung, and Blood Institute2021 to 2024$1,574,063August 15, 2021July 31, 2025BLAU, HELEN Mreporter.nih.gov
An Alternative Isoform of RRM2B as a Genetic Modifier in Huntington's DiseaseNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$1,567,356July 1, 2020April 30, 2026SEONG, IHN SIKreporter.nih.gov
Effects of ABCD1 Deficiency on Endothelial Function and Permeability to Leukocytes in Cerebral X-linked AdrenoleukodystrophyNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$1,567,356September 1, 2020June 30, 2025MUSOLINO, PATRICIA Lreporter.nih.gov
Atypical TDP43 isoforrms driving neurodegeneration in FTD/ALSNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$1,560,000December 1, 2019November 30, 2025BARMADA, SAMIreporter.nih.gov
HNF1A in human endocrine cell development and functionNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2023$1,556,784July 20, 2020June 30, 2025GADUE, PAUL Jreporter.nih.gov
Epigenomic, transcriptional and cellular dissection of Alzheimer's variantsNIHNational Institute on Aging2021$1,552,886June 15, 2018May 31, 2022KELLIS, MANOLISreporter.nih.gov
IDOL and dyslipidemia in cardiovascular diseasesNIHNational Heart, Lung, and Blood Institute2021 to 2022$1,547,876September 1, 2019July 31, 2024CHEN, YUQING EUGENEreporter.nih.gov
Biodistribution and PK modeling of rat vs. human systemsNIHNational Institute of Environmental Health Sciences2021 to 2022$1,543,653September 11, 2020February 28, 2025SHULER, MICHAEL Lreporter.nih.gov
Role of VGLL1 in human placental development and trophoblast specificationNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2021 to 2023$1,539,133February 1, 2019January 31, 2025SONCIN, FRANCESCAreporter.nih.gov
Defining the Human Articular Chondrocyte LineageNIHNational Institute of Arthritis and Musculoskeletal and Skin Diseases2021 to 2023$1,537,754April 1, 2019February 28, 2025CRAFT, APRIL MARIEreporter.nih.gov
Cardiomyocyte phenotype and mechanotransduction in Filamin C gene variants causing arrhythmogenic cardiomyopathyNIHNational Heart, Lung, and Blood Institute2021 to 2023$1,528,574January 1, 2020December 31, 2024MESTRONI, LUISAreporter.nih.gov
Modulating an Astrocyte Hemichannel to Delay Spatial and Temporal Progression in ALS.NIHNational Institute of Neurological Disorders and Stroke2021 to 2024$1,527,714July 1, 2020June 30, 2025MARAGAKIS, NICHOLAS Jreporter.nih.gov
Mechanism of apicosome-driven lumen formation during human and mouse embryogenesisNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2021 to 2024$1,525,138September 1, 2020June 30, 2025TANIGUCHI, KENICHIROreporter.nih.gov
Neurxtem Neural Organoid Human Platform Development for Substance and Opioid Use DisordersNIHNational Institute on Drug Abuse2021 to 2022$1,516,917May 1, 2020January 31, 2023ANAND, RENEreporter.nih.gov
Senescence-Induced Progression of Alzheimer's DiseaseNIHNational Institute on Aging2021 to 2024$1,508,646September 15, 2020May 31, 2026WANG, GAVIN YONGreporter.nih.gov
One-compound, one-islet: A high-throughput platform for small-molecule discoveryNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2022$1,507,666September 20, 2019July 31, 2023WAGNER, BRIDGET Kreporter.nih.gov
Microscale models of inflammation and its resolutionNIHNational Institute of Allergy and Infectious Diseases2021 to 2022$1,504,556April 25, 2018March 31, 2024BEEBE, DAVID Jreporter.nih.gov
Leveraging Human iPSC-derived beta-cells to Probe Antigen Specificity of Anti-islet Memory T Cells in T1DNIHNational Institute of Diabetes and Digestive and Kidney Diseases2023 to 2024$1,503,173February 1, 2023July 31, 2025TEYTON, LUCreporter.nih.gov
Fine-mapping psychiatricdisease variants that affect post-transcriptional gene regulationNIHNational Institute of Mental Health2021 to 2022$1,501,550July 5, 2021June 30, 2024KNOWLES, DAVID ARTHURreporter.nih.gov
Combinatorial Actions of Genetic Variants and Gender Bias of Alzherimer's DiseaseNIHNational Institute on Aging2021$1,501,262September 30, 2017May 31, 2023ROSENFELD, MICHAEL Greporter.nih.gov
An integrative cellular blueprint of vertebrate tissue developmentNIHOffice of the Director, National Institutes of Health2021 to 2022$1,500,000September 15, 2018August 31, 2024TRAVER, DAVIDreporter.nih.gov
Chromatin dynamics in the regulation of herpes simplex virus 1 gene expression.NIHNational Institute of Allergy and Infectious Diseases2021 to 2024$1,498,123May 11, 2020April 30, 2025SCHANG, LUIS M.reporter.nih.gov
HiDef B8: Commercialization and scaled production of defined, robust, and cost-effective media for iPSCsNIHNational Institute of General Medical Sciences2021 to 2022$1,495,522May 17, 2021March 31, 2024REES, STEVEN Dreporter.nih.gov
Uncover the role of glia-neuron crosstalk in hereditary spastic paraplegiasNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$1,491,787June 1, 2020May 31, 2026LI, XUE-JUNreporter.nih.gov
A micromachining fluidic cantilever for single cell advanced patch clamping and cellular characterization using atomic force microscopyNIHNational Institute of General Medical Sciences2022 to 2023$1,485,554May 1, 2022April 30, 2025CHAND, AMIreporter.nih.gov
Rare mutations in Cystic Fibrosis: Overcoming barriers to personalized medicineNIHNational Heart, Lung, and Blood Institute2021 to 2022$1,482,032August 1, 2018April 30, 2025SORSCHER, ERIC Jreporter.nih.gov
Gene expression profiling of IPSC derived neurons in Autism Spectrum DisorderNIHNational Institute of Mental Health2021 to 2022$1,478,393April 6, 2018December 31, 2022HALLMAYER, JOACHIM Freporter.nih.gov
Novel epigenetic mechanisms in neuronal development and cognitive functionNIHNational Institute of Mental Health2021 to 2022$1,473,810August 10, 2012August 31, 2023POMEROY, SCOTT LORENreporter.nih.gov
Modular Platform for Combinatorial Epigenome ManipulationNIHNational Human Genome Research Institute2021 to 2022$1,469,440January 1, 2018December 31, 2023ADAMS, MARK Dreporter.nih.gov
Transcriptional Factor SOX2, LncRNA HBL1, microRNA1 and PRC2 Epigenetic Complex Compose a Network to Orchestrate Cardiac Differentiation from Human Pluripotent Stem CellsNIHNational Heart, Lung, and Blood Institute2021 to 2023$1,465,719July 1, 2019June 30, 2025YANG, LEIreporter.nih.gov
Genetic Pathways in Ceramide-Associated Lipotoxic Cardiomyopathy and Heart FailureNIHNational Heart, Lung, and Blood Institute2021 to 2023$1,462,500December 10, 2019May 31, 2024BODMER, ROLFreporter.nih.gov
Tuberous Sclerosis Complex Patients iPSC-derived NPCs and NCCs as Human Model Systems to Identify Novel TargetsNIHNational Institute of Neurological Disorders and Stroke2021 to 2023$1,460,553June 15, 2019May 30, 2025RAMESH, VIJAYAreporter.nih.gov
Novel pro-healing scaffolds for cell therapiesNIHNational Institute of General Medical Sciences2021 to 2023$1,460,064May 1, 2020February 28, 2025CRISA, LAURAreporter.nih.gov
Beyond Pseudotime: Enhanced Single-cell Genomics Tools for Understanding the Temporal Dynamics of Development and DiseaseNIHNational Institute of General Medical Sciences2021 to 2024$1,458,360September 1, 2020August 31, 2025CUSANOVICH, DARREN Areporter.nih.gov
Identifying mTOR Dependent Periods During Brain DevelopmentNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$1,451,078September 1, 2020August 31, 2024IHRIE, REBECCA Areporter.nih.gov
Functional and molecular basis of ineffective erythropoiesis in SF3B1-mutant myelodysplastic syndromesNIHNational Heart, Lung, and Blood Institute2021 to 2023$1,444,574June 1, 2020May 31, 2025BRADLEY, ROBERT Kreporter.nih.gov
Engineered Human Heart Slice for Testing Drug-Induced ArrhythmiaNIHNational Heart, Lung, and Blood Institute2021 to 2022$1,436,457April 1, 2020March 31, 2024BOHELER, KENNETH RICHARDreporter.nih.gov
Altered inflammatory response associated with acquired DNMT3A mutationsNIHNational Heart, Lung, and Blood Institute2021 to 2022$1,432,778May 1, 2021September 30, 2022BYUN, MINJIreporter.nih.gov
Predicting the multi-omic impact of psychiatric GWAS associationsNIHNational Institute of Mental Health2021 to 2022$1,431,911February 1, 2019June 30, 2022HUCKINS, LAURA MARIANNEreporter.nih.gov
Characterization of ApoE4 Induced Phospholipid Dysregulation in AD PathogenesisNIHNational Institute on Aging2021$1,431,396June 15, 2015July 29, 2023CAI, DONGMINGreporter.nih.gov
SMCHD1 Pathways as Candidate Targets for FSHDNIHNational Institute of Arthritis and Musculoskeletal and Skin Diseases2022 to 2024$1,429,596April 25, 2014June 30, 2025TAPSCOTT, STEPHEN Jreporter.nih.gov
Harnessing stem cells and synthetic gene circuits to repair glomerular injuryNIHNational Institute of Diabetes and Digestive and Kidney Diseases2023$1,425,761September 1, 2023August 31, 2026MUSAH, SAMIRAreporter.nih.gov
Alzheimer's disease-replicated brain microphysiological system to model AD physiopathology and its influenceon gliovasculature and immune systemNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$1,423,803February 1, 2021January 31, 2026YUN, YEOHEUNGreporter.nih.gov
Sphingolipid Signaling and Chemotherapy-Induced Peripheral NeurotoxicityNIHNational Cancer Institute2021 to 2023$1,422,549April 1, 2021August 31, 2023KROETZ, DEANNA Lreporter.nih.gov
Investigating mechanisms of vertebrate myoblast fusion using zebrafish as a modelNIHNational Institute of Arthritis and Musculoskeletal and Skin Diseases2021 to 2024$1,417,766August 1, 2020May 31, 2025CHEN, ELIZABETH Hreporter.nih.gov
Molecular Mechanisms of Epilepsy-Causing Mutations in IKM channels: anti-epileptic effect of Lipophilic compounds.NIHNational Institute of Neurological Disorders and Stroke2021 to 2024$1,409,055January 1, 2020March 31, 2025BARRO-SORIA, RENEreporter.nih.gov
Use of IPSC to define role of astrocytes in specifying risk for onset of cerebral adrenoleukodystrophyNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$1,404,090July 1, 2021June 30, 2026SINGH, JASPREETreporter.nih.gov
DNA repair pathway choice mediates somatic cell reprogrammingNIHNational Institute of General Medical Sciences2021 to 2023$1,401,318September 1, 2020May 31, 2025EGLI, DIETER MEINRADreporter.nih.gov
Mechanisms of mTOR-independent axon growth and guidance defects in TSC2 mutant human neuronsNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$1,400,852May 1, 2020April 30, 2026GOMEZ, TIMOTHY Mreporter.nih.gov
Define the mechanisms of aortopathy in bicuspid aortic valve patientsNIHNational Heart, Lung, and Blood Institute2021 to 2022$1,393,504April 13, 2018March 31, 2024YANG, BOreporter.nih.gov
Pathogenesis of Emery-Dreifuss Muscular DystrophyNIHNational Institute of Arthritis and Musculoskeletal and Skin Diseases2021 to 2024$1,385,343May 15, 2003June 30, 2026WORMAN, HOWARD Jreporter.nih.gov
Decoding the Spatial Grammar of Developmental SignalingNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2023$1,383,800September 20, 2023August 31, 2026LORD, NATHAN DALEreporter.nih.gov
Transcriptional regulation of cardiac pathological remodeling by REV-ERBαNIHNational Heart, Lung, and Blood Institute2021 to 2023$1,381,290May 8, 2019April 30, 2025ZHANG, LILEIreporter.nih.gov
Human pluripotent stem cells for the study of gastrointestinal dysmotilityNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2024$1,380,385April 15, 2020March 31, 2025FATTAHI, FARANAKreporter.nih.gov
Distinct contributions of mesenchymal cell niches in the therapeutic potential of the hedgehog pathway in triple negative breast cancerNIHNational Institute of General Medical Sciences2021 to 2023$1,379,794August 1, 2020July 31, 2025DOMENECH, MARIBELLAreporter.nih.gov
Role of SUMOylation in Mitochondrial/Synaptic Axis Dysfunction Induced by Abnormal Tau in FTDNIHNational Institute of Neurological Disorders and Stroke2023 to 2024$1,376,782September 19, 2023August 31, 2028QUINZII, CATARINA M.reporter.nih.gov
Protection of early embryogenesis and pluripotent stem cells against genetic parasites through a primitive immune systemNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2021 to 2024$1,375,266March 23, 2020February 28, 2025ZWAKA, THOMAS P.reporter.nih.gov
Developing a microfluidic human neurovascular unit system to investigate genetic and age-related risk factors in Alzheimer's diseaseNIHNational Institute on Aging2022 to 2024$1,372,731September 30, 2022August 31, 2025SPROUL, ANDREW ALEXANDERreporter.nih.gov
Protein Homeostasis and Proteotoxicity MechanismsNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$1,365,060February 1, 2015May 31, 2026LIN, JONATHANreporter.nih.gov
Gene-environment interactions in epithelial morphogenesisNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2021 to 2023$1,364,784April 9, 2019March 31, 2026XIA, YINGreporter.nih.gov
Molecular mechanisms and genetic drivers of reciprocal genomic disordersNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2021 to 2022$1,364,240September 15, 2018June 30, 2024TALKOWSKI, MICHAEL Ereporter.nih.gov
Scalable platform for optimizing human cardiac tissue engineering via optical pacing and on-demand oxygenationNIHNational Heart, Lung, and Blood Institute2021 to 2022$1,364,129January 1, 2019December 31, 2024ENTCHEVA, EMILIAreporter.nih.gov
Quantitative Cu-Homeostasis in Live Mammalian Cells at the Single-Molecule LevelNIHNational Institute of General Medical Sciences2021 to 2023$1,362,518August 15, 2019May 31, 2025CHEN, TAI-YENreporter.nih.gov
Microbiome-triggered reprogramming and mutation of colon epithelial cells leading to tumor stem-like cellsNIHNational Cancer Institute2021 to 2023$1,358,184April 1, 2019March 31, 2025HUYCKE, MARK Mreporter.nih.gov
Multi-scale modeling of inherited pediatric cardiomyopathiesNIHNational Heart, Lung, and Blood Institute2021$1,355,405September 1, 2017January 31, 2023PARKER, KEVIN KITreporter.nih.gov
Cardiac Revascularization with Direct Reprogramming ApproachesNIHNational Heart, Lung, and Blood Institute2021 to 2023$1,347,408February 12, 2020January 31, 2025YOON, YOUNG-SUPreporter.nih.gov
Study of Selective Cell and System Vulnerability in Alzheimer's DiseaseNIHNational Institute on Aging2022$1,344,626September 1, 2022April 30, 2023LI, YUNreporter.nih.gov
Stem cell-based tissue engineering for myotendinous junction modeling and repairNIHNational Institute of Arthritis and Musculoskeletal and Skin Diseases2021 to 2024$1,344,008April 1, 2020January 31, 2026SUZUKI, MASATOSHIreporter.nih.gov
Id3 and VSMC in Murine and Human AtherosclerosisNIHNational Heart, Lung, and Blood Institute2021 to 2022$1,342,034August 28, 2019June 30, 2023MCNAMARA, COLEEN Areporter.nih.gov
Immunomyoblasts in muscle regenerationNIHNational Institute of Arthritis and Musculoskeletal and Skin Diseases2021 to 2023$1,336,330May 10, 2021April 30, 2024KUANG, SHIHUANreporter.nih.gov
Microphysiological Human Tissue Systems for Monitoring of Genome Editing OutcomesNIHNational Heart, Lung, and Blood Institute2021 to 2022$1,336,300September 1, 2019August 31, 2024GERSBACH, CHARLES A.reporter.nih.gov
Loss-of-Function Analyses of SETD1A in Human Neural ModelsNIHNational Institute of Mental Health2021 to 2022$1,335,252July 1, 2021April 30, 2023PANG, ZHIPING P.reporter.nih.gov
Common schizophrenia variants functioning in developmental human cortical interneuronsNIHNational Institute of Mental Health2023 to 2024$1,324,075July 1, 2023August 29, 2024CHUNG, SANGMIreporter.nih.gov
Epigenetic control of muscle stem cell function by PASK-Wdr5 signalingNIHNational Institute of Arthritis and Musculoskeletal and Skin Diseases2021 to 2024$1,322,588February 25, 2020November 30, 2025KIKANI, CHINTAN Kreporter.nih.gov
Functional genetics of tissue factor in bleeding and thrombotic riskNIHOffice of the Director, National Institutes of Health2021 to 2023$1,312,500September 16, 2019August 31, 2025SCHULMAN, SOLreporter.nih.gov
Cellular and Molecular Basis of Human Primordial Germ Cell SpecificationNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2021 to 2024$1,311,481December 20, 2014April 30, 2026CLARK, AMANDERreporter.nih.gov
Elucidating the FOXF1 gene regulatory network in human alveologenesisNIHNational Heart, Lung, and Blood Institute2023 to 2024$1,307,495February 15, 2023January 31, 2028GU, MINGXIAreporter.nih.gov
Identification of therapeutic targets for leukemia stem cells in AML-iPSC modelsNIHNational Cancer Institute2021 to 2022$1,306,690March 1, 2018February 28, 2023PAPAPETROU, EIRINIreporter.nih.gov
A Translational Bioinformatics Approach to Rescuing Synaptic and Neurophysiologic Dysfunction in Alzheimer's DiseaseNIHNational Institute on Aging2021 to 2022$1,305,180September 15, 2018May 31, 2025TEICH, ANDREW FRANKLINreporter.nih.gov
The Spatiotemporal Landscape of the Human Brain EpitranscriptomeNIHNational Institute of Mental Health2021 to 2022$1,303,579July 1, 2018March 31, 2025MASON, CHRISTOPHER EDWARDreporter.nih.gov
Intersection of HIV, Opiods, and Amyloid Fibrils in a CNS Organoid ModelNIHNational Institute on Drug Abuse2021 to 2024$1,302,196July 1, 2020March 31, 2026SWANSTROM, RONALD Ireporter.nih.gov
Zika Virus Capsid Protein Mediated Blockage of host microRNA machineryNIHNational Institute of Neurological Disorders and Stroke2021 to 2023$1,302,099May 1, 2019February 28, 2025ZHAO, ZHENreporter.nih.gov
Functional drug fingerprinting with all-optical electrophysiologyNIHNational Institute of Mental Health2022$1,296,058September 20, 2019June 30, 2023HARWOOD, BENJAMIN NATHANIELreporter.nih.gov
Probing the role of SORL1 and endosomal network genetic variation on Alzheimer's disease phenotypes in human neurons.NIHNational Institute on Aging2021 to 2022$1,294,076September 30, 2018May 31, 2025YOUNG, JESSICA ELAINEreporter.nih.gov
Systematic elucidation of endosomal trafficking as a therapeutic opportunity in AD using CRISPR-based functional genomicsNIHNational Institute on Aging2021 to 2022$1,292,532September 30, 2018May 31, 2023KAMPMANN, MARTINreporter.nih.gov
Tissue Chip Models for Cardiovascular Development and DiseaseNIHNational Heart, Lung, and Blood Institute2021 to 2023$1,275,636February 20, 2020January 31, 2025SETHU, PALANIAPPANreporter.nih.gov
Skeletal Muscle Stem Cells Derived from TeratomasNIHNational Institute of Arthritis and Musculoskeletal and Skin Diseases2021 to 2023$1,274,254May 1, 2019April 30, 2024KYBA, MICHAELreporter.nih.gov
A High Content Chemical Screen to Identify the Drug Candidates Promoting Human Beta Cell ProliferationNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2023$1,271,250April 1, 2020February 29, 2024CHEN, SHUIBINGreporter.nih.gov
Astrocyte dysfunction in idiopathic autismNIHNational Institute of Mental Health2021 to 2023$1,271,250July 1, 2019April 30, 2025COLAK, DILEKreporter.nih.gov
Metabolism of AMD iPSC-derived RPENIHNational Eye Institute2022 to 2024$1,268,628September 30, 2022August 31, 2025CHAO, JENNIFER RAYMINGreporter.nih.gov
Molecular Quiescence and Cardiomyocyte MaturationNIHNational Heart, Lung, and Blood Institute2021 to 2023$1,267,500April 5, 2020March 31, 2024LEE, RICHARD Treporter.nih.gov
Highly Specific ZFN-Based HSC Gene Editing Therapies Identified By In Vivo Barcode Nanoparticle Screens and Rationally Designed mRNANIHNational Center for Advancing Translational Sciences2022 to 2023$1,264,949September 16, 2019August 31, 2024DAHLMAN, JAMESreporter.nih.gov
IDENTIFICATION AND PRECLINICAL EVALUATION OF NOVEL THERAPEUTIC APPROACHES TO DYSKERATOSIS CONGENITANIHNational Heart, Lung, and Blood Institute2021 to 2022$1,260,063July 1, 2019June 30, 2024JOHNSON, F. BRADreporter.nih.gov
Translational control in neurogenesis by ZNF804ANIHNational Institute of Mental Health2021 to 2024$1,239,705April 1, 2020January 30, 2026MAO, YINGWEIreporter.nih.gov
Functional 3D tissue-engineering models of the cerebrovasculature incorporating stem cell-derived brain microvascular endothelial cells, pericytes, and astrocytesNIHNational Institute of Neurological Disorders and Stroke2021 to 2023$1,233,416April 1, 2019December 31, 2024SEARSON, PETER Creporter.nih.gov
Identification of the specific risk allele responsible for oxidative stress in ARMS2/HTRA1-related AMDNIHNational Eye Institute2022 to 2024$1,225,973September 30, 2022August 31, 2025TSANG, STEPHEN Hreporter.nih.gov
A Human iPSC-based 3D Microphysiological System for Modeling Cardiac Dysfunction in MicrogravityNIHNational Center for Advancing Translational Sciences2021 to 2022$1,222,769July 1, 2022June 30, 2023KIM, DEOK-HOreporter.nih.gov
In vivo development and reactivity of human autoreactive T cellsNIHNational Institute of Allergy and Infectious Diseases2021 to 2023$1,215,000November 15, 2018October 31, 2024CREUSOT, REMI Jreporter.nih.gov
Investigating the co-transcriptional impact of genetic variation on gene regulation and diseaseNIHNational Institute of General Medical Sciences2021 to 2023$1,215,000May 1, 2019April 30, 2024LI, YANGreporter.nih.gov
Whole genome sequencing consortium on Frontotemporal dementia with underlying TDP-43 pathologyNIHNational Institute of Neurological Disorders and Stroke2021$1,213,868September 25, 2017August 31, 2024RADEMAKERS, ROSAreporter.nih.gov
Uncovering the Genetic Mechanisms Behind Joint-Specific OsteoarthritisNIHNational Institute of Arthritis and Musculoskeletal and Skin Diseases2021 to 2022$1,202,184April 1, 2018January 31, 2024CAPELLINI, TERENCE Dreporter.nih.gov
Modeling Inherited Neurodevelopmental Disorders with Human Induced Pluripotent Stem CellsNIHNational Institute of Neurological Disorders and Stroke2021 to 2022$1,198,680July 1, 2019April 30, 2024JINNAH, HYDER Areporter.nih.gov
Mechanistic insights into the role of mitochondrial iron in doxorubicin-induced cardiomyopathy using human induced pluripotent stem cellsNIHNational Heart, Lung, and Blood Institute2021 to 2023$1,196,250March 15, 2020February 28, 2025ARDEHALI, HOSSEINreporter.nih.gov
Live imaging of stem cell dynamics in cornea regenerationNIHNational Eye Institute2021 to 2023$1,194,375September 1, 2019July 31, 2025ROMPOLAS, PANTELEIMONreporter.nih.gov
Stromal cell therapy as a treatment against Gastrointestinal Acute Radiation Syndrome (GI-ARS)NIHNational Institute of Allergy and Infectious Diseases2021 to 2022$1,193,484March 9, 2018February 29, 2024GUHA, CHANDANreporter.nih.gov
Determining the mechanism of IFIH1 disease-associated variants on beta-cell and immune responses in Type 1 diabetesNIHNational Institute of Diabetes and Digestive and Kidney Diseases2023$1,192,518July 1, 2023June 30, 2025TSE, HUBERT Mreporter.nih.gov
Development of Mass Spectrometry Strategies to Decipher Dynamic Lysosomal Dysfunctions in Frontotemporal DementiaNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$1,188,229April 15, 2021August 31, 2024HAO, LINGreporter.nih.gov
Depositing Data Generated from Drug Test on microJoint Model into the Microphysiology Systems DatabaseNIHNational Center for Advancing Translational Sciences2021$1,186,687August 20, 2017June 30, 2023LIN, HANGreporter.nih.gov
Transcriptional and Epigenetic Control of Pluripotency and Self-Renewal by Honey Bee Royalactin and its human structural analogNIHNational Institute of General Medical Sciences2021 to 2023$1,186,613August 15, 2020January 18, 2024WANG, KEVIN CHUN-KAIreporter.nih.gov
Gene Editing vs Neutrophil Elastase Inhibitors for Treatment of ELANE Associated NeutropeniaNIHNational Heart, Lung, and Blood Institute2021 to 2022$1,184,117April 15, 2020March 31, 2025DALE, DAVID CHANDLERreporter.nih.gov
Subcellular RNA-Proteome Mapping in Subtype- and Circuit-Specific Growth Cones: Development, Cell Biology, Disease, and RegenerationNIHNational Institute of Neurological Disorders and Stroke2021$1,183,000September 30, 2017July 31, 2024MACKLIS, JEFFREY Dreporter.nih.gov
Multicomponent solutions for the preservation of cell therapy productsNIHNational Heart, Lung, and Blood Institute2021 to 2023$1,174,641August 3, 2017June 30, 2025HUBEL, ALLISONreporter.nih.gov
Deciphering the mechanisms associated with high-risk AMD genotypes for ARMS2/HTRA1 andComplement Factor HNIHNational Eye Institute2022 to 2024$1,174,621September 30, 2022August 31, 2025FERRINGTON, DEBORAH ANNreporter.nih.gov
Functional drug fingerprinting with all-optical electrophysiologyNIHNational Institute of Mental Health2023 to 2024$1,171,510September 20, 2019October 31, 2025HARWOOD, BENJAMIN NATHANIELreporter.nih.gov
Inhibiting Cell Death for Protecting Cardiac InjuryNIHNational Heart, Lung, and Blood Institute2021 to 2023$1,170,000July 1, 2020June 30, 2024ZHU, HUAreporter.nih.gov
AMPK/SIRT1/PGC-1α, a critical pathway in dry AMDNIHNational Eye Institute2021 to 2023$1,169,908April 1, 2019March 31, 2025GOLESTANEH, NADYreporter.nih.gov
Synaptic Pruning and Complement Gene in Schizophrenia: Imaging & Cellular StudiesNIHNational Institute of Mental Health2021 to 2022$1,167,870July 12, 2018April 30, 2024PRASAD, KONASALE Mreporter.nih.gov
Selective interactome vulnerability across the Alzheimer’s disease spectrumNIHNational Institute on Aging2021$1,162,517May 15, 2021April 30, 2023CHIOSIS, GABRIELAreporter.nih.gov
Cellular and Molecular Mechanisms of FUS-related ALS/FTDNIHNational Institute of Neurological Disorders and Stroke2021 to 2023$1,161,739April 15, 2013January 31, 2025PANDEY, UDAI Breporter.nih.gov
CD4 T cell stemness and inflammatory bowel diseaseNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2023$1,157,862September 1, 2020May 31, 2025HARRINGTON, LAURIE ELLENreporter.nih.gov
Tead1 and Cardiac AdaptationNIHNational Heart, Lung, and Blood Institute2021 to 2023$1,150,020July 1, 2019June 30, 2025MOULIK, MOUSUMIreporter.nih.gov
Magnetic Steering and Longitudinal Visualization of Stem Cells for Trabecular Meshwork Therapy in GlaucomaNIHNational Eye Institute2021 to 2022$1,149,852July 1, 2019June 30, 2024ETHIER, C ROSSreporter.nih.gov
Drug development for tuberous sclerosis complex and other pediatric epileptogenic diseases using neurovascular and cardiac microphysiological modelsNIHNational Center for Advancing Translational Sciences2021$1,149,180July 21, 2017June 30, 2023WIKSWO, JOHN PETERreporter.nih.gov
Mechanisms of TL1A-driven Paneth Cell dysfunction in IBDNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2023$1,147,500January 1, 2020December 31, 2024TARGAN, STEPHAN R.reporter.nih.gov
Mitochondria and TFAM in Osteoblast BiologyNIHNational Institute of Arthritis and Musculoskeletal and Skin Diseases2022 to 2024$1,147,343July 15, 2019November 30, 2024SCHIPANI, ERNESTINAreporter.nih.gov
Neuroinflammation and vascular development in GMHNIHNational Institute of Neurological Disorders and Stroke2023 to 2024$1,143,982August 1, 2023July 31, 2028HUANG, ERIC Jreporter.nih.gov
Defining molecular mechanisms by which stimulant evoked dopamine drives inflammation and neuronal dysfunction in neuroHIVNIHNational Institute on Drug Abuse2023 to 2024$1,142,172July 1, 2023June 30, 2025GASKILL, PETER JESSEreporter.nih.gov
Modeling Hepatoblastoma using pluripotent stem cell derived hepatocyte-like cellsNIHNational Cancer Institute2021 to 2023$1,140,447August 19, 2019July 31, 2025SCHWARTZ, ROBERT Ereporter.nih.gov
SPOTs: Optical Technologies for Instantly Quantifying Multicellular Response ProfilesNIHNational Institute of General Medical Sciences2021 to 2023$1,137,513June 1, 2020March 31, 2025CHIOU, PEI-YUreporter.nih.gov
Lung epithelial cell specification in human pluripotent stem cellsNIHNational Heart, Lung, and Blood Institute2021 to 2022$1,135,872April 1, 2019March 31, 2023SNOECK, HANS-WILLEM Ereporter.nih.gov
Gene Regulatory Non-Coding RNAs in the Human HeartNIHNational Heart, Lung, and Blood Institute2021 to 2022$1,120,487August 17, 2019July 31, 2023MOSKOWITZ, IVAN PAULreporter.nih.gov
R01 Renewal: Collaboration of chromatin remodeling and signaling pathways in pluripotencyNIHNational Institute of General Medical Sciences2021 to 2023$1,119,364July 10, 2015July 31, 2024SRIDHARAN, RUPAreporter.nih.gov
Translational Epigenetics with XIST: Silencing Trisomy in Human Organoid and Mouse Models of Down SyndromeNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2021 to 2022$1,118,382September 19, 2018June 30, 2025LAWRENCE, JEANNE BENTLEYreporter.nih.gov
Using human iPSC derived microglia and chimeric models to examine the role of PLCG2 in Alzheimers diseaseNIHNational Institute on Aging2021 to 2022$1,117,111September 30, 2018May 31, 2024DAVTYAN, HAYKreporter.nih.gov
Single Cell Transcriptomics of the Opioid Use Disorder and HIV Syndemic in the Human BrainNIHNational Institute on Drug Abuse2021$1,105,894November 5, 2020January 31, 2022CHENG, CHRISTINEreporter.nih.gov
Brain-region-specific humanized cortical interneuron miceNIHNational Institute of Mental Health2023 to 2024$1,102,988July 1, 2023August 29, 2024CHUNG, SANGMIreporter.nih.gov
CFTR modulates innate immune response in biliary epithelium: Role in the pathogenesis and treatment of Cystic-Fibrosis-related liver disease.NIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2022$1,093,088May 1, 2013July 31, 2024STRAZZABOSCO, MARIOreporter.nih.gov
Epigenetic Regulation of Chondrogenesis and Cartilage DevelopmentNIHNational Institute of Arthritis and Musculoskeletal and Skin Diseases2021 to 2023$1,092,641March 5, 2021February 28, 2024WU, CHIA-LUNGreporter.nih.gov
Dysregulation of p97/VCP disease mutants in IBM and FTLD-UNIHNational Institute of Neurological Disorders and Stroke2021 to 2022$1,088,809July 1, 2018April 30, 2024CHOU, TSUI-FENreporter.nih.gov
Develop GABAergic Neuron Protectors for Treating ApoE4-Related Alzheimer's DiseaseNIHNational Institute on Aging2021$1,086,082May 1, 2019November 30, 2021MAHLEY, ROBERT W.reporter.nih.gov
Analysis of non-canonical functions of microRNAsNIHNational Institute of General Medical Sciences2021 to 2023$1,085,053March 2, 2023February 28, 2025CIFUENTES, DANIELreporter.nih.gov
Structural Mechanisms Underlying the Activity Regulation of the Receptor-like Protein Tyrosine Phosphatase, CD148/PTPRJNIHNational Institute of General Medical Sciences2021 to 2023$1,080,500May 1, 2020April 30, 2025ZHU, JIEQINGreporter.nih.gov
Signal Integration During Eye FormationNIHNational Eye Institute2021 to 2023$1,077,805September 1, 2020August 31, 2025BROWN, NADEAN Lreporter.nih.gov
Bone Marrow Spatial Transcriptomics to Enhance In Vitro Platelet ProductionNIHNational Heart, Lung, and Blood Institute2021 to 2023$1,076,177August 1, 2021July 31, 2025CANTOR, ALAN B.reporter.nih.gov
Genetic Signals in Ventricular HypertrophyNIHNational Heart, Lung, and Blood Institute2021 to 2022$1,071,326February 1, 2007July 31, 2024SEIDMAN, JONATHAN Greporter.nih.gov
Regulation of cardiac power output in health and diseaseNIHNational Heart, Lung, and Blood Institute2021 to 2022$1,070,114April 1, 2018March 31, 2024GREENBERG, MICHAEL Jreporter.nih.gov
A 3D IN VITRO DISEASE MODEL OF ATRIAL CONDUCTIONNIHNational Heart, Lung, and Blood Institute2021$1,065,481September 1, 2017July 31, 2023GEORGE, STEVEN CARLreporter.nih.gov
DISEASE MODELING AND PHENOTYPIC DRUG SCREENING FOR DYSTROPHIC CARDIOMYOPATHYNIHNational Heart, Lung, and Blood Institute2021 to 2022$1,063,408May 15, 2020April 30, 2024KIM, DEOK-HOreporter.nih.gov
HIF-2alpha, a Novel Regulator of OsteoblastogenesisNIHNational Institute of Arthritis and Musculoskeletal and Skin Diseases2021 to 2023$1,057,667January 11, 2019December 31, 2023SCHIPANI, ERNESTINAreporter.nih.gov
Role of L-type Calcium Channels in Human Interneuron Migration and IntegrationNIHNational Institute of Mental Health2021 to 2022$1,055,351August 10, 2018April 30, 2024PASCA, SERGIUreporter.nih.gov
T-Cell Targeting for GVHDNIHNational Heart, Lung, and Blood Institute2021 to 2022$1,054,732August 1, 1995December 31, 2023BLAZAR, BRUCE Rreporter.nih.gov
Mechanisms of Hedgehog Regulation of Intestinal Villus MorphogenesisNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2023$1,053,000March 1, 2019February 28, 2025WALTON, KATHERINE DEMPSEYreporter.nih.gov
Function of MLL in transcription regulationNIHNational Institute of General Medical Sciences2021 to 2023$1,052,562April 1, 2009April 30, 2025DOU, YALIreporter.nih.gov
Distal enhancers controlling motor neuron gene expression programNIHNational Institute of Neurological Disorders and Stroke2021 to 2022$1,043,568December 1, 2018November 30, 2023WICHTERLE, HYNEKreporter.nih.gov
A Genetically Engineered Human Fetal Liver Niche as a Novel Platform for Biomanufacturing of Hematopoietic Stem CellsNIHNational Heart, Lung, and Blood Institute2021 to 2022$1,037,088July 1, 2019June 30, 2025EBRAHIMKHANI, MO REZAreporter.nih.gov
Essential requirements of Eif4a3 in brain development and diseaseNIHNational Institute of Neurological Disorders and Stroke2021 to 2023$1,035,767June 1, 2013May 31, 2025SILVER, DEBRAreporter.nih.gov
Transcription Factor Control of Liver Development and FunctionNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2023$1,032,346January 1, 2020June 30, 2024CIRILLO, LISA Areporter.nih.gov
Viscoelastic Properties of Normal and OA ChondronsNIHNational Institute on Aging2021 to 2022$1,027,495January 1, 1998March 31, 2025GUILAK, FARSHIDreporter.nih.gov
A Neurovascular Microphysiological SystemNIHNational Institute of Neurological Disorders and Stroke2021 to 2023$1,020,468July 1, 2019June 30, 2024MURPHY, WILLIAM L.reporter.nih.gov
Identifying therapeutic strategies for the multisystem genetic disorder Pseudoxanthoma ElasticumNIHNational Institute of Arthritis and Musculoskeletal and Skin Diseases2021 to 2023$1,015,872February 1, 2020November 30, 2024DEB, ARJUNreporter.nih.gov
Structure-Function Analysis of SarcospanNIHNational Institute of Arthritis and Musculoskeletal and Skin Diseases2021 to 2023$1,015,872September 24, 2001May 31, 2025CROSBIE, RACHELLE HOPEreporter.nih.gov
Modeling Anthracycline-Induced Cognitive Impairment Using iPSC-Derived Brain-On-ChipsNIHNational Heart, Lung, and Blood Institute2021$1,003,658August 5, 2014March 31, 2023WU, JOSEPH C.reporter.nih.gov
Microfluidic cell squeezing platform for the transdifferentiation of somatic cells for efficient generation of a cell replacement therapy for Parkinsons DiseaseNIHNational Institute of General Medical Sciences2022$1,001,356March 14, 2022December 15, 2022BRIDGEN, DEVINreporter.nih.gov
RIGERR: Resources for Investigating Genetic and Epigenetic Regulation of Renal DiseaseNIHNational Institute of Diabetes and Digestive and Kidney Diseases2022$999,999September 15, 2022July 31, 2027LIANG, MINGYUreporter.nih.gov
Pioneer transcription factors in aging and neurodegenerationNIHNational Institute on Aging2021 to 2023$994,263August 15, 2021July 31, 2023WEBB, ASHLEY Ereporter.nih.gov
Mechanisms of Shear Induction of Blood-Brain Barrier Phenotypes in Human iPSC-derived Brain Endothelial ProgenitorsNIHNational Institute of Neurological Disorders and Stroke2021 to 2023$993,822February 15, 2019January 31, 2025PALECEK, SEAN Preporter.nih.gov
1/2 Cross modal integration of molecular and physiological networks in ASDNIHNational Institute of Mental Health2021$993,129September 21, 2017July 31, 2023GESCHWIND, DANIEL Hreporter.nih.gov
Study and Treatment of Mitochondrial DNA Depletion Syndrome 3 Using iPSCsNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2022$989,672January 15, 2019December 31, 2023DUNCAN, STEPHEN Areporter.nih.gov
Targeting PTEN to ameliorate muscular dystrophy in a mouse modelNIHNational Institute of Arthritis and Musculoskeletal and Skin Diseases2022 to 2024$989,224January 27, 2022December 31, 2024KUANG, SHIHUANreporter.nih.gov
Chaperone-mediated Autophagy and Synaptic Dysfunction in Parkinson's DiseaseNIHNational Institute of Neurological Disorders and Stroke2021 to 2022$986,946August 1, 2018May 31, 2023MAO, ZIXUreporter.nih.gov
Functional consequences of mutations in spliceosomal small nuclear RNAsNIHNational Institute of General Medical Sciences2021 to 2022$968,639August 1, 2019July 31, 2024PADGETT, RICHARD Areporter.nih.gov
Thyroid Hormone Signaling in Human HepatocytesNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2022$965,058April 1, 2019November 14, 2022HOLLENBERG, ANTHONY Nreporter.nih.gov
CRISPR-Cas9 editing in C9orf72 patient derived iPSCNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$961,200July 1, 2020June 30, 2025CLELLAND, CLAIREreporter.nih.gov
Transplantation of Testis Stem Cells in Large AnimalsNIHOffice of the Director, National Institutes of Health2021 to 2024$956,232September 1, 2013February 28, 2026DOBRINSKI, INAreporter.nih.gov
PLT+ Characterization and IND-Enabling StudiesNIHNational Heart, Lung, and Blood Institute2021$952,100April 1, 2016June 30, 2023DYKSTRA, BRADFORDreporter.nih.gov
Non-Invasive Tracking of Genome-Corrected iPS cells in ALSNIHNational Institute of Biomedical Imaging and Bioengineering2021 to 2022$950,463September 1, 2019July 31, 2025BULTE, JEFF W.reporter.nih.gov
Determining the role of CLN3 in the eyeNIHNational Eye Institute2021 to 2022$949,115April 1, 2019January 31, 2025SINGH, RUCHIRAreporter.nih.gov
Dynamic double network hydrogel for generating pancreatic organoids from induced pluripotent stem cellsNIHNational Institute of Diabetes and Digestive and Kidney Diseases2022 to 2023$936,976August 1, 2022June 30, 2024LIN, CHIEN-CHIreporter.nih.gov
Microphysiology Systems Database Supplement to Tissue Chips for Precision Treatment of Catecholaminergic Polymorphic Ventricular Tachycardia-SupplementNIHNational Center for Advancing Translational Sciences2021$932,065August 1, 2020June 30, 2022PU, WILLIAM TSWENCHINGreporter.nih.gov
Notch-enriched Mesenchymal Stromal Cells for Bone Allograft RepairNIHNational Institute of Arthritis and Musculoskeletal and Skin Diseases2022 to 2024$932,010January 1, 2019December 31, 2025DONG, YUFENGreporter.nih.gov
Explore the APOE e4-mediated p53 activation in Alzheimer's DiseaseNIHOffice of the Director, National Institutes of Health2021 to 2022$928,125February 1, 2019January 31, 2024ZHAO, RUIreporter.nih.gov
Optimization of electromechanical monitoring of engineered heart tissuesNIHNational Heart, Lung, and Blood Institute2023 to 2024$924,063April 1, 2023March 31, 2025MCNALLY, ELIZABETH Mreporter.nih.gov
Establishing and benchmarking advanced methods to comprehensively characterize somatic genome variation in single human cellsNIHNational Institute of Neurological Disorders and Stroke2023 to 2024$922,052April 19, 2023March 31, 2025URBAN, ALEXANDER ECKEHARTreporter.nih.gov
The Role of MDM2 in FMRP regulation of neuronal developmentNIHNational Institute of Mental Health2021 to 2022$917,272July 9, 2018April 30, 2024ZHAO, XINYUreporter.nih.gov
Exploring the Pathophysiology of AD and ADRDs with 3D Asteroid ModelsNIHNational Institute on Aging2021$916,247September 15, 2021August 31, 2024WOLOZIN, BENJAMIN Lreporter.nih.gov
Effect of Microgravity on Drug Responses Using Engineered Heart TissuesNIHNational Center for Advancing Translational Sciences2021 to 2022$911,144July 22, 2022January 31, 2023WU, JOSEPH C.reporter.nih.gov
Cell and Molecular Consequences of Alzheimer's Disease Genetic Variants on BBB Integrity and FunctionNIHNational Institute of Neurological Disorders and Stroke2024$908,817September 15, 2020August 31, 2025YOUNG-PEARSE, TRACY Lreporter.nih.gov
High throughput platform for simultaneous multiparametric assessment of cardiac physiology for heart failure drug developmentNIHNational Heart, Lung, and Blood Institute2023 to 2024$908,049September 1, 2023June 30, 2026MERCOLA, MARKreporter.nih.gov
Development and validation of a novel bioprinted, human-diabetic cardiac organoid modelNIHNational Heart, Lung, and Blood Institute2021 to 2023$906,000September 15, 2020August 31, 2025HAN, KYUNG-ANreporter.nih.gov
Development of Pharmacological Treatment of OsteochondromasNIHNational Institute of Arthritis and Musculoskeletal and Skin Diseases2021 to 2023$905,493February 1, 2019January 31, 2025ENOMOTO-IWAMOTO, MOTOMIreporter.nih.gov
2/2 - Cell Type and Region-Specific Regulatory Networks in Human Brain Development and DisordersNIHNational Institute of Mental Health2021 to 2022$903,832August 15, 2018May 31, 2023STATE, MATTHEW W.reporter.nih.gov
The Cdk5/35 KinaseNIHNational Institute of Neurological Disorders and Stroke2021 to 2022$903,600April 1, 1996June 30, 2023TSAI, LI-HUEIreporter.nih.gov
Do we need Y chromosome for successful reproduction?NIHEunice Kennedy Shriver National Institute of Child Health & Human Development2021 to 2022$886,145August 25, 2012March 31, 2024WARD, MONIKA Areporter.nih.gov
Development and Maintenance of the Human Photoreceptor-Bipolar Cell Synapse.NIHNational Eye Institute2021 to 2024$884,824June 1, 2020May 31, 2025NAGIEL, AARONreporter.nih.gov
Nonsense-Mediated mRNA Decay and Nonsense-Mediated mRNA Decay FactorsNIHNational Institute of General Medical Sciences2021 to 2022$884,498August 1, 1999July 31, 2023MAQUAT, LYNNE Ereporter.nih.gov
Connecting TDP-43 Pathology to the Molecular Profiles of NeurodegenerationNIHNational Institute of Neurological Disorders and Stroke2024$879,816August 15, 2020July 31, 2025GALE HAMMELL, MOLLYreporter.nih.gov
Safety and Efficacy of Human Clinical Trials Using Kidney-on-a-Chip Microphysiological SystemsNIHNational Center for Advancing Translational Sciences2021$875,910July 15, 2020July 31, 2022HIMMELFARB, JONATHANreporter.nih.gov
AI-guided miniproteins driving the production and functional endurance of pancreatic islet tissue from pluripotent stem cells.NIHNational Institute of Diabetes and Digestive and Kidney Diseases2024$875,714September 1, 2024August 31, 2025CIRULLI, VINCENZINOreporter.nih.gov
lncRNAs and Anesthetic-Induced Developmental NeurotoxicityNIHNational Institute of General Medical Sciences2021 to 2022$871,546May 15, 2014May 31, 2024BAI, XIAOWENreporter.nih.gov
Regulation of diverse microglial phenotypes in neurodegenerationNIHNational Institute on Aging2023$871,419September 15, 2023August 31, 2025JAYADEV, SUMANreporter.nih.gov
REGULATION OF NICHE CELL DIFFERENTIATION TO SUSTAIN INTESTINAL STEM CELL REGENERATION AGAINST GUT INFLAMMATIONNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2023$870,194January 1, 2020December 31, 2024HAN, XIAONANreporter.nih.gov
Optimization of CRISPR genome editor and its delivery strategy for C9orf72 frontotemporal dementiaNIHNational Institute of Neurological Disorders and Stroke2023$869,959August 18, 2023July 31, 2025CLELLAND, CLAIREreporter.nih.gov
Targeting the Mutant H3.3 Pathway in GliomaNIHNational Institute of Neurological Disorders and Stroke2021 to 2022$868,352September 30, 2018June 30, 2024KNOEPFLER, PAUL Sreporter.nih.gov
Engineering human islet-like organoids for transplantationNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021$865,040September 30, 2018May 31, 2022EVANS, RONALD Mreporter.nih.gov
Integration of systems and synthetic biology to advance development of human tissues ex vivoNIHNational Institute of Biomedical Imaging and Bioengineering2021 to 2022$852,965September 30, 2019June 30, 2024EBRAHIMKHANI, MO REZAreporter.nih.gov
Determining the role of OXR1 in aging and Alzheimer's diseaseNIHNational Institute on Aging2021$851,414September 30, 2021August 31, 2023KAPAHI, PANKAJreporter.nih.gov
Molecular Basis of Human Hepatic Progenitor Cell FormationNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2022$846,782July 1, 2014June 30, 2024DUNCAN, STEPHEN Areporter.nih.gov
Gene Therapy for Hearing and Balance DisordersNIHNational Institute on Deafness and Other Communication Disorders2021 to 2022$846,072August 1, 2018July 31, 2023COREY, DAVID Preporter.nih.gov
Regulation of UBE3A Imprinted ExpressionNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2021 to 2022$833,150September 1, 2018August 31, 2025GRAVELEY, BRENTON R.reporter.nih.gov
Functional characterization of Alzheimer's disease associated genetic variantsNIHNational Institute on Aging2021$831,005September 30, 2017May 31, 2023SHEN, YINreporter.nih.gov
microRNA therapies for advanced brain tumorsNIHNational Cancer Institute2022 to 2024$828,287April 1, 2020December 31, 2025BHERE, DEEPAKreporter.nih.gov
Myocardial Repair with a Novel Engineered Cardiac Muscle PatchNIHNational Heart, Lung, and Blood Institute2021 to 2022$825,686September 1, 2019August 31, 2025ZHU, WUQIANGreporter.nih.gov
Mechanisms and Treatment of Cardiac and Skeletal Muscular Dysfunction in Barth SyndromeNIHNational Heart, Lung, and Blood Institute2021 to 2022$823,560February 6, 2021April 30, 2024PACAK, CHRISTINA A.reporter.nih.gov
Genomic Prediction of Doxorubicin-Induced CardiotoxicityNIHNational Cancer Institute2021 to 2022$822,880September 13, 2018August 31, 2023BURRIDGE, PAUL W.reporter.nih.gov
iPSC-Derived Airway Basal Cells to Model Human Airway Development and DiseaseNIHNational Heart, Lung, and Blood Institute2021 to 2022$822,064September 1, 2018August 31, 2024HAWKINS, FINNreporter.nih.gov
Diversity Supplement -- Vertebrate Photoreceptor Development and RegenerationNIHNational Eye Institute2021 to 2022$817,376August 1, 2012July 31, 2024MORRIS, ANN Creporter.nih.gov
Molecular Diagnostics using a Nanopore to Analyze Secretions from Single CellsNIHNational Institute of General Medical Sciences2021 to 2022$809,222March 1, 2019February 28, 2025TIMP, GREGORY LOUISreporter.nih.gov

Organizations

OrganizationPlaceNIH awardsNIH amountNSF awardsNSF amount
Rutgers University New BrunswickNew Brunswick, NJ8$48.4 million0$0
Stanford UniversityStanford, CA58$48.1 million0$0
Columbia University Health SciencesNew York, NY35$46.4 million0$0
Icahn School of Medicine at Mount SinaiNew York, NY35$35.2 million0$0
University of California, San DiegoLa Jolla, CA40$34.1 million0$0
University of California, San FranciscoSan Francisco, CA45$32.3 million0$0
University of PennsylvaniaPhiladelphia, PA31$31.4 million0$0
University of California Los AngelesLos Angeles, CA32$29.3 million0$0
Boston Children's HospitalBoston, MA25$28.7 million0$0
Emory UniversityAtlanta, GA28$28.5 million0$0
University of Colorado DenverAurora, CO11$27.7 million0$0
University of Pittsburgh at PittsburghPittsburgh, PA22$27 million0$0
University of California-IrvineIrvine, CA12$24.4 million0$0
Johns Hopkins UniversityBaltimore, MD37$24.4 million0$0
University of WashingtonSeattle, WA31$24 million0$0
Case Western Reserve UniversityCleveland, OH8$22.8 million0$0
University of Nebraska Medical CenterOmaha, NE4$22.7 million0$0
University of Wisconsin-MadisonMadison, WI28$21.7 million0$0
Northwestern University at ChicagoChicago, IL28$21.6 million0$0
Washington UniversitySaint Louis, MO29$21 million0$0
Massachusetts General HospitalBoston, MA21$20.5 million0$0
University of Michigan at Ann ArborAnn Arbor, MI27$20.3 million0$0
Massachusetts Institute of TechnologyCambridge, MA16$20.3 million0$0
J. David Gladstone InstitutesSan Francisco, CA11$18.7 million0$0
Univ of North Carolina Chapel HillChapel Hill, NC16$17.5 million0$0
Cincinnati Childrens Hosp Med CTRCincinnati, OH15$15.6 million0$0
Weill Medical Coll of Cornell UnivNew York, NY14$15 million0$0
Boston University Medical CampusBoston, MA23$14.8 million0$0
Univ of Massachusetts Med SCH WorcesterWorcester, MA14$14.4 million0$0
University of MinnesotaMinneapolis, MN27$14.1 million0$0
Yale UniversityNew Haven, CT11$13.8 million0$0
University of Alabama at BirminghamBirmingham, AL8$13.3 million0$0
University of Illinois at ChicagoChicago, IL7$13.1 million0$0
Children's Hosp of PhiladelphiaPhiladelphia, PA12$12.8 million0$0
Medical College of WisconsinMilwaukee, WI15$12.4 million0$0
Baylor College of MedicineHouston, TX11$10.8 million0$0
University of Miami School of MedicineCoral Gables, FL7$10.8 million0$0
Mclean HospitalBelmont, MA3$10.6 million0$0
University of RochesterRochester, NY10$10.6 million0$0
Vanderbilt UniversityNashville, TN12$10.6 million0$0
Vanderbilt University Medical CenterNashville, TN7$9.6 million0$0
Harvard UniversityCambridge, MA10$9.3 million0$0
Cedars-Sinai Medical CenterLos Angeles, CA10$9 million0$0
University of Maryland BaltimoreBaltimore, MD9$8.7 million0$0
Scripps Research Institute, theLa Jolla, CA5$8.7 million0$0
Broad Institute, Inc.Cambridge, MA8$8.3 million0$0
Harvard Medical SchoolBoston, MA10$8.2 million0$0
Beckman Research Institute/city of HopeDuarte, CA3$7.8 million0$0
Beth Israel Deaconess Medical CenterBoston, MA3$7.7 million0$0
Albert Einstein College of MedicineBronx, NY8$7.6 million0$0
Buck Institute for Research on AgingNovato, CA5$7.3 million0$0
The Emmes Company, LLCRockville, MD1$7.3 million0$0
Regenerative Research FoundationAlbany, NY4$7 million0$0
Cleveland Clinic Lerner Com-CwruCleveland, OH8$7 million0$0
Indiana University IndianapolisIndianapolis, IN12$7 million0$0
University of ChicagoChicago, IL11$7 million0$0
Versiti Blood Health, Inc.Milwaukee, WI3$6.7 million0$0
Ut Southwestern Medical CenterDallas, TX12$6.7 million0$0
University of Southern CaliforniaLos Angeles, CA8$6.6 million0$0
Brigham and Women's HospitalBoston, MA9$6.5 million0$0
SUNY at BuffaloAmherst, NY5$6.5 million0$0
Harvard University D/b/a Harvard School of Public HealthBoston, MA1$6.4 million0$0
Mayo Clinic JacksonvilleJacksonville, FL5$6.4 million0$0
Sanford Burnham Prebys Medical Discovery InstituteLa Jolla, CA5$5.9 million0$0
Quiver Bioscience Inc.Cambridge, MA3$5.8 million0$0
University of Connecticut SCH of Med/dntFarmington, CT9$5.7 million0$0
University of UtahSalt Lake City, UT6$5.6 million0$0
Upstate Medical UniversitySyracuse, NY5$5.5 million0$0
Rutgers Biomedical and Health SciencesNewark, NJ5$5.1 million0$0
Georgetown UniversityWashington, DC3$5.1 million0$0
Vala Sciences, Inc.San Diego, CA4$5.1 million0$0
Temple Univ of the CommonwealthPhiladelphia, PA7$5 million0$0
University of California-BerkeleyBerkeley, CA3$4.9 million0$0
Duke UniversityDurham, NC7$4.7 million0$0
University of VirginiaCharlottesville, VA6$4.7 million0$0
University of FloridaGainesville, FL4$4.6 million0$0
University of KentuckyLexington, KY5$4.5 million0$0
Tufts University BostonBoston, MA2$4.4 million0$0
University of IowaIowa City, IA11$4.2 million0$0
University of California at DavisDavis, CA8$4.2 million0$0
Altis Biosystems, Inc.Durham, NC3$4.1 million0$0
University of South Carolina at ColumbiaColumbia, SC4$4 million0$0
New York University School of MedicineNew York, NY4$3.9 million0$0
Endeavor Health Clinical OperationsEvanston, IL2$3.9 million0$0
Medical University of South CarolinaCharleston, SC4$3.5 million0$0
Stem Pharm, Inc.Madison, WI4$3.4 million0$0
University of California-Santa CruzSanta Cruz, CA2$3.4 million0$0
Sloan-Kettering Inst Can ResearchNew York, NY5$3.3 million0$0
Rockefeller UniversityNew York, NY3$3.2 million0$0
Adventhealth OrlandoOrlando, FL2$3.2 million0$0
Lieber Institute, Inc.Baltimore, MD3$3.1 million0$0
Children's Research InstituteWashington, DC3$3.1 million0$0
University of Colorado at BoulderBoulder, CO5$3 million0$0
New York Medical CollegeValhalla, NY3$3 million0$0
University of Texas HLTH Sci CTR HoustonHouston, TX3$3 million0$0
Arizona State UniversityScottsdale, AZ7$3 million0$0
Thomas Jefferson UniversityPhiladelphia, PA8$2.9 million0$0
Modulo Bio, Inc.San Diego, CA1$2.9 million0$0
Massachusetts Eye and Ear InfirmaryBoston, MA1$2.9 million0$0
Fred Hutchinson Cancer CenterSeattle, WA2$2.9 million0$0

Funding by fiscal year

Fiscal yearNIH awardsNIH amountNSF awardsNSF amount
20255$16,425,3780$0
2024442$204,238,8720$0
2023682$316,562,0000$0
2022837$395,972,0250$0
2021920$460,114,0100$0

Open federal funding opportunities

From Grants.gov: notices that funded awards in this table, and open notices on the same agency and assistance listing.

Open opportunityNumberAgencyListingClosesAward ceilingWhy it matches
Change of Recipient Organization (Type 7 Parent Clinical Trial Optional)PA-24-254NIHJuly 12, 2027Not listedNotice number printed on 1 award here
Functional Target Validation for Alzheimer's Disease-Related DementiasRFA-NS-26-034NIH93.853November 6, 2026Not listedSame assistance listing 93.853 as 283 awards here
Clinical Trials and Ancillary Studies Conducted within NIH-Funded Clinical Trial Research Networks (UG3/UH3 - Clinical Trial Required)PAR-27-007NIH93.853November 10, 2026Not listedSame assistance listing 93.853 as 283 awards here
Amyotrophic Lateral Sclerosis (ALS) Intermediate Patient Population Expanded Access (U01 Clinical Trial Required)RFA-NS-26-001NIH93.853November 10, 2026Not listedSame assistance listing 93.853 as 283 awards here
Genomic and Biologic Therapies for ADRD (U01 Clinical Trial Optional)RFA-NS-26-030NIH93.853November 10, 2026Not listedSame assistance listing 93.853 as 283 awards here
Ethical, Legal and Social Implications (ELSI) Exploratory/Developmental Research Grant (R21 Clinical Trial Optional)PAR-25-369NIH93.853November 18, 2026Not listedSame assistance listing 93.853 as 283 awards here
Ethical, Legal and Social Implications (ELSI) Research (R01 Clinical Trial Optional)PAR-25-371NIH93.853November 18, 2026Not listedSame assistance listing 93.853 as 283 awards here
NIH StrokeNet Clinical Trials and Biomarker Studies for Stroke Treatment, Recovery, and Prevention (UG3/UH3 Clinical Trial Optional)PAR-25-052NIH93.853November 19, 2026Not listedSame assistance listing 93.853 as 283 awards here
HEAL Initiative: Pain Research Enhancement Program (PREP) (R15 Clinical Trial Optional)RFA-AT-25-003NIH93.853November 23, 2026$375,000Same assistance listing 93.853 as 283 awards here
Maximizing the Scientific Value of Data Generated by the Environmental Influences on Child Health Outcomes (ECHO) Program: Ruth L. Kirschstein National Research Service Award (NRSA) Individual Postdoctoral Fellowship (F32)RFA-OD-27-008NIH93.853December 2, 2026Not listedSame assistance listing 93.853 as 283 awards here
Emerging Global Leader Award (K43 Independent Clinical Trial Required)PAR-24-295NIH93.853December 3, 2026Not listedSame assistance listing 93.853 as 283 awards here
Emerging Global Leader Award (K43 Independent Clinical Trial Not Allowed)PAR-24-296NIH93.853December 3, 2026Not listedSame assistance listing 93.853 as 283 awards here
NIH Research Software Engineer (RSE) Award (R50 Clinical Trials Not Allowed)RFA-OD-24-011NIH93.853December 4, 2026Not listedSame assistance listing 93.853 as 283 awards here
Academic Research Enhancement Award (AREA) for Undergraduate-Focused Institutions (R15 Clinical Trial Required)PAR-24-214NIH93.853January 7, 2027$375,000Same assistance listing 93.853 as 283 awards here
HEAL Initiative: Studies to Enable Analgesic Discovery (R61/R33 - Clinical Trial Not Allowed)RFA-NS-25-023NIH93.853January 15, 2027$350,000Same assistance listing 93.853 as 283 awards here
HEAL Initiative: Integrative Management of Chronic Pain and OUD for Whole Recovery (IMPOWR): Research Centers (RM1 Clinical Trial Required)RFA-DA-28-011NIH93.853January 26, 2027Not listedSame assistance listing 93.853 as 283 awards here
HEAL Initiative: Integrative Management of chronic Pain and OUD for Whole Recovery (IMPOWR) - Building Engagement, Assistance, Capacity, Outreach, and Networks (BEACON) Center (U2C Clinical Trial Not Allowed)RFA-DA-28-012NIH93.853January 26, 2027Not listedSame assistance listing 93.853 as 283 awards here
Biomedical Research Environment and Sponsored Programs Administration Development (BRE-SPAD) Program (UC2- Clinical Trial Not Allowed)PAR-24-268NIH93.853January 27, 2027$500,000Same assistance listing 93.853 as 283 awards here
Translational Neural Devices (R61/R33 - Clinical Trial Optional)PAR-25-053NIH93.853January 28, 2027Not listedSame assistance listing 93.853 as 283 awards here
BRAIN Initiative: Preclinical Proof of Concept for Novel Recording and Modulation Technologies in the Human CNS (R18 - Clinical Trial Not Allowed)RFA-NS-24-031NIH93.853January 28, 2027$750,000Same assistance listing 93.853 as 283 awards here

Updated November 3, 2026. Read from NIH RePORTER ExPORTER and NSF Award Search. Published by NIH and NSF as U.S. government data. NIH awards are fiscal years 2021 to 2025 (NIH files published to 2026-07-09); NSF awards are fiscal years 2022 to 2026 (NSF files published to 2026-11-02). NIH amounts are the total cost of each fiscal year in the window; NSF amounts are the funds obligated in the window. Organizations are matched on the UEI. Open opportunities come from Grants.gov and match on agency and assistance listing number, and on the notice number NIH prints on an award. Free to reuse with credit to SpecStream under CC BY 4.0. Spot a wrong value? Write to [email protected] with the link to this page.