Data / Research funding / Primary Immunodeficiencies

Primary Immunodeficiencies: 223 NIH awards ($309M) to 85 organizations

Name: NIH and NSF awards on Primary Immunodeficiencies
Creator: SpecStream
License: https://creativecommons.org/licenses/by/4.0/

223 NIH awards ($309M) in the NIH spending category Primary Immunodeficiencies, to 85 organizations, read 2026-11-03. NIH fiscal years 2021 to 2025.

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Topic: NIH spending category

Awards

223 awards in the window.

Award	Agency	Institute or division	Fiscal year	Amount in window	Start	End	Principal investigator	Source
IPP: AUTOIMMUNE DISEASES STATISTICAL AND CLINICAL COORDINATING CENTER (ADSCCC)	NIH	National Institute of Allergy and Infectious Diseases	2022 to 2025	$32,128,916	February 1, 2025	January 31, 2026	MILLIN, CHRISTINA	reporter.nih.gov
USIDNET: A resource for clinical immunologists	NIH	National Institute of Allergy and Infectious Diseases	2022 to 2025	$5,578,391	August 24, 2022	July 31, 2027	SULLIVAN, KATHLEEN E	reporter.nih.gov
Multi-racial genetic analysis of hidradenitis suppurativa	NIH	National Institute of Arthritis and Musculoskeletal and Skin Diseases	2021 to 2025	$4,095,633	July 16, 2021	June 30, 2026	LIAO, WILSON	reporter.nih.gov
Collaborative multi-site project to speed the identification and management of rare genetic immune diseases	NIH	National Institute of Allergy and Infectious Diseases	2021 to 2025	$3,948,415	February 25, 2021	January 31, 2027	BUTTE, MANISH J	reporter.nih.gov
Inborn errors of immunity in patients with life-threatening COVID-19	NIH	National Institute of Allergy and Infectious Diseases	2021 to 2025	$3,707,765	July 12, 2021	June 30, 2026	CASANOVA, JEAN-LAURENT	reporter.nih.gov
Primary Immune Deficiency Treatment Consortium (PIDTC): A resource to drive scientific and clinical advances related to the treatment of inborn errors of immunity	NIH	National Institute of Allergy and Infectious Diseases	2024 to 2025	$3,580,422	September 1, 2025	August 31, 2029	DVORAK, CHRISTOPHER CRAIG	reporter.nih.gov
Gene therapy for SCID-X1 with low dose busulfan and a SIN-lentiviral vector	NIH	National Institute of Allergy and Infectious Diseases	2021 to 2025	$3,369,470	July 7, 2016	December 31, 2029	WILLIAMS, DAVID A	reporter.nih.gov
Second-Generation Novel Liver Stage Active Antimalarials	NIH	National Institute of Allergy and Infectious Diseases	2021 to 2025	$3,320,110	April 1, 2021	March 31, 2027	KELLY, JANE X	reporter.nih.gov
Developing second generation SCID pig models: filling the gaps to improve translation of therapeutics in regenerative medicine	NIH	Office of the Director, National Institutes of Health	2021 to 2025	$3,219,338	February 15, 2020	July 31, 2029	TUGGLE, CHRISTOPHER	reporter.nih.gov
GENETIC, IMMUNOLOGIC AND MECHANISTIC BASIS OF HUMAN NK CELL DEFICIENCY	NIH	National Institute of Allergy and Infectious Diseases	2021 to 2024	$3,093,388	January 19, 2016	August 31, 2026	ORANGE, JORDAN SCOTT	reporter.nih.gov
Genetic modifiers of congenital heart disease in 22q11.2 deletion syndrome	NIH	National Heart, Lung, and Blood Institute	2022 to 2025	$3,070,980	February 1, 2022	January 31, 2027	MORROW, BERNICE E	reporter.nih.gov
The molecular and cellular mechanisms of the STAT3 mutation-mediated pulmonary disorder in Autosomal Dominant Hyper IgE Syndrome (AD-HIES)	NIH	National Heart, Lung, and Blood Institute	2022 to 2025	$2,990,146	March 5, 2022	February 28, 2026	BOUCHER, RICHARD CHARLES	reporter.nih.gov
Identification of metabolic alterations during cortical development in a human cellular model for 22q11.2 deletion syndrome	NIH	National Institute of Mental Health	2022 to 2025	$2,912,854	January 18, 2022	October 31, 2026	PASCA, ANCA MIRABELA	reporter.nih.gov
Mechanisms of mucosal autoinflammation elucidated by a novel monogenic transcription factor defect	NIH	National Institute of Allergy and Infectious Diseases	2021 to 2025	$2,902,111	April 15, 2021	March 31, 2026	LUCAS, CARRIE L.	reporter.nih.gov
Mechanisms of STING-associated autoinflammation	NIH	National Institute of Allergy and Infectious Diseases	2021 to 2025	$2,866,706	March 1, 2019	January 31, 2029	MINER, JONATHAN J	reporter.nih.gov
Pathobiology of VPS45 severe congenital neutropenia	NIH	National Institute of Allergy and Infectious Diseases	2021 to 2024	$2,830,535	February 7, 2020	January 31, 2026	NEWBURGER, PETER E	reporter.nih.gov
WAVE Regulatory Complex in Primary Immunodeficiency Disease and autoimmunity	NIH	National Institute of Allergy and Infectious Diseases	2021 to 2025	$2,801,318	February 10, 2021	January 31, 2026	IRITANI, BRIAN M	reporter.nih.gov
Strawberry notch homologues in T cell homeostasis and function	NIH	National Institute of Allergy and Infectious Diseases	2021 to 2025	$2,783,309	January 21, 2021	December 31, 2026	ZHONG, XIAOPING	reporter.nih.gov
Restoring Immune Balance in Hiddradenitis Suppurativa	NIH	National Institute of Arthritis and Musculoskeletal and Skin Diseases	2021 to 2024	$2,776,428	May 1, 2020	April 30, 2026	ROSENBLUM, MICHAEL DAVID	reporter.nih.gov
Phage/Salmonella interactions during oxidative stress	NIH	National Institute of Allergy and Infectious Diseases	2025	$2,727,148	September 4, 2025	August 31, 2029	VAZQUEZ-TORRES, ANDRES	reporter.nih.gov
Regulation of 22q11 Genes in Embryonic and Adult Forebrain	NIH	Eunice Kennedy Shriver National Institute of Child Health & Human Development	2022 to 2025	$2,688,826	April 1, 2003	June 30, 2027	LAMANTIA, ANTHONY S	reporter.nih.gov
Unraveling the molecular mechanisms of impaired central tolerance in COPA syndrome	NIH	National Institute of Allergy and Infectious Diseases	2022 to 2025	$2,664,560	March 1, 2022	February 28, 2027	SHUM, ANTHONY	reporter.nih.gov
Lead optimization and target identification of drugs targeting hypnozoites	NIH	National Institute of Allergy and Infectious Diseases	2021 to 2024	$2,647,674	August 7, 2020	July 31, 2025	KYLE, DENNIS E	reporter.nih.gov
Cell fate choices by Tbx1 in forming the mammalian heart	NIH	National Heart, Lung, and Blood Institute	2021 to 2025	$2,603,457	August 20, 2020	April 30, 2029	MORROW, BERNICE E	reporter.nih.gov
The Genetics of Personalized Functional MRI Networks	NIH	National Institute of Mental Health	2023 to 2025	$2,562,033	June 16, 2023	March 31, 2026	ALEXANDER-BLOCH, AARON FELIX	reporter.nih.gov
Inborn errors of immunity in children with herpes simplex encephalitis	NIH	National Institute of Allergy and Infectious Diseases	2021 to 2024	$2,560,389	April 6, 2010	March 31, 2026	CASANOVA, JEAN-LAURENT	reporter.nih.gov
Genome-Wide Dissection of Mendelian Susceptibility to Mycobacterial Disease	NIH	National Institute of Allergy and Infectious Diseases	2021 to 2025	$2,542,500	May 1, 2011	April 30, 2027	CASANOVA, JEAN-LAURENT	reporter.nih.gov
Novel Multiple-Stage Active Antimalarials	NIH	National Institute of Allergy and Infectious Diseases	2021 to 2025	$2,520,964	June 14, 2019	August 31, 2030	KANCHARLA, PAPIREDDY	reporter.nih.gov
New York Regional Inborn Errors of Immunity Resource Initiative League (NY-ROYAL)	NIH	National Institute of Allergy and Infectious Diseases	2023 to 2025	$2,501,144	September 1, 2023	August 31, 2028	MILNER, JOSHUA D.	reporter.nih.gov
Mechanisms of STING-driven autoinflammation	NIH	National Heart, Lung, and Blood Institute	2023 to 2025	$2,494,975	May 15, 2023	April 30, 2027	FITZGERALD, KATHERINE A.	reporter.nih.gov
Genome-wide search for inborn errors of IL-17 immunity underlying chronic mucocutaneous candidiasis	NIH	National Institute of Allergy and Infectious Diseases	2021 to 2025	$2,457,750	November 14, 2016	February 28, 2027	CASANOVA, JEAN-LAURENT	reporter.nih.gov
Adenylate Kinase 2 Deficiency and the Failure of Myelopoiesis	NIH	National Heart, Lung, and Blood Institute	2022 to 2025	$2,449,815	April 1, 2022	March 31, 2027	WEINACHT, KATJA GABRIELE	reporter.nih.gov
Hermansky-Pudlak syndrome and melanosome formation	NIH	National Eye Institute	2022 to 2025	$2,448,434	May 1, 2004	June 30, 2027	MARKS, MICHAEL S	reporter.nih.gov
Intracellular nucleic acid detection in autoimmunity	NIH	National Institute of Allergy and Infectious Diseases	2021 to 2024	$2,440,748	May 15, 2010	April 30, 2025	STETSON, DANIEL B	reporter.nih.gov
Molecular Genetics of the Telomere Biology Disorders	NIH	National Heart, Lung, and Blood Institute	2022 to 2025	$2,421,352	May 15, 2016	June 30, 2026	BERTUCH, ALISON A	reporter.nih.gov
Washington University in St. Louis UDN Diagnostic Center of Excellence	NIH	National Institute of Neurological Disorders and Stroke	2023 to 2025	$2,411,983	September 21, 2018	July 31, 2028	DICKSON, PATRICIA I	reporter.nih.gov
Underdiagnosis of primary immunodeficiency disorders among racial and ethnic minorities: Recognize and Educate	NIH	National Institute on Minority Health and Health Disparities	2022 to 2024	$2,386,620	September 19, 2022	May 31, 2027	ONG, MEI-SING	reporter.nih.gov
Regulation of Ribosome Biogenesis in Hematopoietic Stem Cells	NIH	National Institute of Diabetes and Digestive and Kidney Diseases	2021 to 2024	$2,385,337	September 18, 2020	August 31, 2025	TONG, WEI	reporter.nih.gov
Hematopoietic Regulation via GATA Switches	NIH	National Institute of Diabetes and Digestive and Kidney Diseases	2021 to 2025	$2,385,213	February 1, 2006	November 30, 2029	BRESNICK, EMERY H.	reporter.nih.gov
Omics, mice and men: Development of precision transfusion medicine	NIH	National Heart, Lung, and Blood Institute	2023 to 2025	$2,341,220	September 18, 2009	July 31, 2028	GLADWIN, MARK T	reporter.nih.gov
Molecular Dissection of the 22q11.2 Deletion Syndrome	NIH	National Institute of General Medical Sciences	2021 to 2024	$2,272,016	August 15, 2018	August 31, 2025	EMANUEL, BEVERLY S	reporter.nih.gov
Neurodevelopmental defects of the thalamocortical pathway as a convergent feature of psychiatric disorders	NIH	National Institute of Mental Health	2023 to 2025	$2,271,274	May 1, 2023	January 31, 2028	NOWAKOWSKI, TOMASZ	reporter.nih.gov
Survival Function of the Fadd-Caspase-8-Flip Complex - MERIT Extension	NIH	National Institute of Allergy and Infectious Diseases	2021 to 2025	$2,268,750	May 1, 2022	April 30, 2027	GREEN, DOUGLAS R.	reporter.nih.gov
Tafazzin and metabolic reprogramming during cardiomyopathy	NIH	National Heart, Lung, and Blood Institute	2021 to 2024	$2,259,577	September 1, 2021	August 31, 2025	CONWAY, SIMON JAMES	reporter.nih.gov
Regulation of SAMHD1 antiviral activity	NIH	National Institute of Allergy and Infectious Diseases	2021 to 2024	$2,242,957	September 20, 2016	June 30, 2025	DIAZ-GRIFFERO, FELIPE	reporter.nih.gov
Mechanisms driving extrafollicular polyreactive B cell lineages in partial RAG deficiency	NIH	National Institute of Allergy and Infectious Diseases	2021 to 2025	$2,232,177	September 22, 2021	August 31, 2027	WALTER, JOLAN ESZTER	reporter.nih.gov
Molecular and cellular mechanisms in food anaphylaxis	NIH	National Institute of Allergy and Infectious Diseases	2021 to 2024	$2,192,068	June 1, 2020	May 31, 2025	GEHA, RAIF SALIM	reporter.nih.gov
Molecular Pathogenesis of Fanconi Anemia	NIH	National Heart, Lung, and Blood Institute	2021 to 2025	$2,183,099	August 1, 1994	December 31, 2027	D'ANDREA, ALAN D.	reporter.nih.gov
Neurodevelopment and Psychosis in the 22q11.2 Copy Number Variants	NIH	National Institute of Mental Health	2023 to 2025	$2,163,535	December 14, 2009	April 30, 2028	BEARDEN, CARRIE E	reporter.nih.gov
Clinical and mechanistic studies defining optimal preparative approaches to infants with IL2RG/JAK3/RAG1/RAG2 SCID: a randomized trial of busulfan dosage	NIH	National Institute of Allergy and Infectious Diseases	2024 to 2025	$2,149,845	August 13, 2024	May 31, 2029	AULETTA, JEFFERY J	reporter.nih.gov
Site-Specific Recombination in Human Health & Disease	NIH	National Institute of General Medical Sciences	2021 to 2025	$2,145,000	June 1, 2016	May 31, 2027	LIEBER, MICHAEL R	reporter.nih.gov
Mechanism and regulation of DNA interstrand cross-link repair	NIH	National Heart, Lung, and Blood Institute	2021 to 2025	$2,138,165	February 1, 2010	July 31, 2028	WALTER, JOHANNES	reporter.nih.gov
Curation of genetic defects causing combined immunodeficiency and infections in children	NIH	Eunice Kennedy Shriver National Institute of Child Health & Human Development	2021 to 2025	$2,115,359	July 1, 2021	June 30, 2028	CHINN, IVAN KINGYUE	reporter.nih.gov
Epigenetic dysregulation of muscle differentiation in Kabuki syndrome	NIH	National Institute of Arthritis and Musculoskeletal and Skin Diseases	2022 to 2025	$2,111,652	February 2, 2022	December 31, 2026	GUSSONI, EMANUELA	reporter.nih.gov
Mechanistic elucidation of pathogenic CBM complex mutations associated with atopic disease	NIH	National Institute of Allergy and Infectious Diseases	2023 to 2025	$2,100,471	July 5, 2023	June 30, 2028	SNOW, ANDREW L	reporter.nih.gov
Innate immune defenses against a cytosolic capsule	NIH	National Institute of Allergy and Infectious Diseases	2021 to 2025	$2,085,271	December 1, 2018	April 30, 2030	MIAO, EDWARD A	reporter.nih.gov
Biochemistry and molecular physiology of the mitochondrial calcium uniporter	NIH	National Institute of Arthritis and Musculoskeletal and Skin Diseases	2021 to 2025	$2,072,213	September 1, 2018	June 30, 2029	GRABAREK, ZENON	reporter.nih.gov
Olfactory and facial markers of developmental risk for psychosis in 22q11 deletion syndrome	NIH	National Institute of Mental Health	2021 to 2024	$2,059,648	September 24, 2019	January 31, 2025	ROALF, DAVID R	reporter.nih.gov
Thymic medullary epithelial cell turnover and control of immune tolerance	NIH	National Institute of Allergy and Infectious Diseases	2021 to 2025	$2,051,250	December 1, 2011	June 30, 2027	ANDERSON, MARK S	reporter.nih.gov
Dissecting the role of acetaldehyde in oral carcinogenesis	NIH	National Institute on Alcohol Abuse and Alcoholism	2022 to 2025	$2,048,776	September 20, 2022	August 31, 2027	BALBO, SILVIA	reporter.nih.gov
Skin probiotics to treat Netherton Syndrome	NIH	National Institute of Arthritis and Musculoskeletal and Skin Diseases	2024 to 2025	$2,033,762	September 15, 2022	August 30, 2026	ZARGAR, AMIN	reporter.nih.gov
Neutrophil Extracellular Traps and Host Immunity	NIH	National Institute of Allergy and Infectious Diseases	2021 to 2025	$2,025,000	March 4, 2021	February 28, 2027	SHARMA, JYOTIKA	reporter.nih.gov
Structural Mechanisms of DNA Damage Sensing and Activation of the ATR, Fanconi Anemia, and ATM Checkpoints	NIH	National Institute of General Medical Sciences	2023 to 2025	$2,017,785	August 1, 2023	April 30, 2027	PAVLETICH, NIKOLA P	reporter.nih.gov
Molecular mechanisms and treatment of cardiomyopathy in Barth Syndrome	NIH	National Heart, Lung, and Blood Institute	2021 to 2025	$1,974,688	April 1, 2021	March 31, 2026	FANG, XI	reporter.nih.gov
The role of SERPINB1 in T cell function and its contribution to human diseases	NIH	National Institute of Allergy and Infectious Diseases	2023 to 2025	$1,957,554	July 5, 2023	June 30, 2028	MARTINEZ BARRICARTE, RUBEN	reporter.nih.gov
Inflammation Phenotypes in Pediatric Sepsis Induced Multiple Organ Failure Renewal	NIH	National Institute of General Medical Sciences	2021 to 2025	$1,842,526	March 1, 2014	June 30, 2028	CARCILLO, JOSEPH A	reporter.nih.gov
The role of inflammation in driving leukemogenesis in germline predisposition syndromes	NIH	National Cancer Institute	2023 to 2025	$1,807,914	May 1, 2022	April 30, 2026	GODLEY, LUCY ANN	reporter.nih.gov
Genome Stability in Glia & Disease	NIH	National Institute of Neurological Disorders and Stroke	2022 to 2025	$1,806,350	July 1, 2022	June 30, 2027	MCKINNON, PETER J	reporter.nih.gov
Targeting CHI3L1 and its receptors in Hermansky-Pudlak Syndrome-associated lung disease	NIH	National Heart, Lung, and Blood Institute	2021 to 2024	$1,769,742	March 20, 2020	February 28, 2026	ZHOU, YANG	reporter.nih.gov
In vivo hematopoietic stem cell genetic modification by viral particles	NIH	National Heart, Lung, and Blood Institute	2024 to 2025	$1,764,905	September 9, 2024	May 31, 2028	BAUER, DANIEL EVAN	reporter.nih.gov
Kindlin-3 signaling in platelets	NIH	National Heart, Lung, and Blood Institute	2022 to 2024	$1,742,425	February 10, 2022	January 31, 2026	MA, YAN-QING	reporter.nih.gov
Common Regulatory Pathways for the Genesis of Lysosome-Related Organelles and Dynamics of Microtubules during Development	NIH	National Institute of Neurological Disorders and Stroke	2021 to 2024	$1,738,337	September 30, 2020	August 31, 2025	GLOVER, DAVID M	reporter.nih.gov
Coding and Noncoding RNA Contributions to 22q11.2 Deletion Syndrome	NIH	National Institute of Allergy and Infectious Diseases	2021 to 2024	$1,737,187	July 1, 2015	June 30, 2026	VAN OERS, NICOLAI STANISLAS CYRILLE	reporter.nih.gov
Safety and Efficacy of Itacitinib in treatment of JAK/STAT pathway disorders with activating mutations	NIH	National Center for Advancing Translational Sciences	2024 to 2025	$1,700,517	September 1, 2021	July 31, 2028	FORBES, LISA	reporter.nih.gov
Aire, a zinc-finger protein that controls autoimmunity	NIH	National Institute of Diabetes and Digestive and Kidney Diseases	2022 to 2025	$1,678,050	March 1, 2002	April 30, 2027	MATHIS, DIANE J	reporter.nih.gov
Defining WASp-dependent pathways in replication stress	NIH	National Institute of Allergy and Infectious Diseases	2023 to 2025	$1,636,788	August 7, 2023	July 31, 2026	VYAS, YATIN M	reporter.nih.gov
Investigation of Self-Nucleic Acids as a Trigger for Neuroinflammation	NIH	National Institute of Neurological Disorders and Stroke	2022 to 2025	$1,626,825	June 1, 2022	May 31, 2027	CHUNG, HACHUNG	reporter.nih.gov
1/2: Neurodevelopmental Trajectories in 22q11.2 Deletion Syndrome in Adolescence and Young Adulthood	NIH	National Institute of Mental Health	2024 to 2025	$1,580,588	February 13, 2024	December 31, 2028	GUR, RAQUEL E	reporter.nih.gov
Dissecting the Molecular Role of TBX1 in the Context of Human Pharyngeal Endoderm Development	NIH	National Heart, Lung, and Blood Institute	2022 to 2025	$1,574,000	May 1, 2022	October 31, 2025	SEBASTIANO, VITTORIO	reporter.nih.gov
Molecular and cellular basis of epidermodysplasia verruciformis	NIH	National Institute of Allergy and Infectious Diseases	2021 to 2024	$1,557,826	February 10, 2020	January 31, 2026	CASANOVA, JEAN-LAURENT	reporter.nih.gov
Identification of Specific Immune Responses in African American Female Patients with Hidradenitis Suppurativa	NIH	National Institute of Arthritis and Musculoskeletal and Skin Diseases	2024 to 2025	$1,553,425	September 18, 2024	August 31, 2029	MI, QING-SHENG	reporter.nih.gov
Characterizing the natural history of sphingosine phosphate lyase insufficiency syndrome (SPLIS): a fundamental step in the development of a targeted cure for this novel atypical sphingolipidosis	NIH	Eunice Kennedy Shriver National Institute of Child Health & Human Development	2024 to 2025	$1,535,635	September 10, 2024	June 30, 2029	SABA, JULIE D	reporter.nih.gov
Mechanism and Regulation of eIF6 in Translation	NIH	National Institute of General Medical Sciences	2022 to 2025	$1,493,845	July 7, 2022	April 30, 2027	ORIGANTI, SOFIA	reporter.nih.gov
Nqo2 in Primaquine-Induced Hemolysis of G6PD-deficient RBCs	NIH	National Heart, Lung, and Blood Institute	2024 to 2025	$1,463,166	May 15, 2024	April 30, 2028	GOLDFARB, ADAM N.	reporter.nih.gov
Enhancer activation mechanisms in cranial neural crest osteoblast differentiation	NIH	National Institute of Dental & Craniofacial Research	2021 to 2024	$1,444,084	September 1, 2021	July 31, 2026	SHPARGEL, KARL BRYAN	reporter.nih.gov
Selective inhibitors of MLCL/CytC Peroxidase in Barth Syndrome	NIH	National Heart, Lung, and Blood Institute	2024 to 2025	$1,430,854	July 1, 2024	June 30, 2028	KAGAN, VALERIAN E	reporter.nih.gov
Modeling and treating T cell immunodeficiency in CHARGE syndrome by ESC- and iPSC-derived thymic epithelial cells	NIH	National Institute of Allergy and Infectious Diseases	2023 to 2025	$1,352,273	February 1, 2023	January 31, 2028	LAI, LAIJUN	reporter.nih.gov
Investigating and targeting the translational landscape of DBA	NIH	National Institute of Diabetes and Digestive and Kidney Diseases	2024 to 2025	$1,351,443	August 1, 2024	May 31, 2029	BARNA, MARIA	reporter.nih.gov
Development, Optimization and Preclinical Modeling of Hematopoietic Stem Cell Gene Editing for the Treatment of RAG1 Immunodeficiency	NIH	National Institute of Allergy and Infectious Diseases	2023 to 2025	$1,327,500	June 8, 2021	May 31, 2026	GENOVESE, PIETRO	reporter.nih.gov
Ion channels regulating plasma cell differentiation and humoral immunity	NIH	National Institute of Allergy and Infectious Diseases	2024 to 2025	$1,317,151	December 13, 2023	October 31, 2028	FESKE, STEFAN	reporter.nih.gov
Linking mitochondrial and synaptic weakness to schizophrenia	NIH	National Institute of Mental Health	2024 to 2025	$1,300,778	July 19, 2024	January 31, 2027	ANDERSON, STEWART A	reporter.nih.gov
Hypoxia's role in regulating stressed hematopoietic stem cells	NIH	National Institute of Diabetes and Digestive and Kidney Diseases	2024 to 2025	$1,300,278	March 1, 2024	December 31, 2027	KAPUR, REUBEN	reporter.nih.gov
Development of real-world motor outcome measures in ataxia-telangiectasia	NIH	National Institute of Neurological Disorders and Stroke	2024 to 2025	$1,275,758	December 15, 2023	November 30, 2028	GUPTA, ANOOPUM SATYAWAN	reporter.nih.gov
Mechanisms of R loop-mediated genome instability in Wiskott-Aldrich syndrome	NIH	National Institute of Allergy and Infectious Diseases	2022 to 2024	$1,273,819	February 7, 2020	January 31, 2026	VYAS, YATIN M	reporter.nih.gov
Redox Regulation of Gingival Inflammation	NIH	National Institute of Dental & Craniofacial Research	2022 to 2024	$1,257,475	December 9, 2019	November 30, 2025	BAGAITKAR, JUHI	reporter.nih.gov
Mechanistic dissection of 22q11.2DS in zebrafish	NIH	National Heart, Lung, and Blood Institute	2024 to 2025	$1,242,466	March 1, 2024	February 29, 2028	BURNS, CAROLINE E	reporter.nih.gov
Defining cerebellar pathophysiology in Ataxia Telangiectasia	NIH	National Institute of Neurological Disorders and Stroke	2024 to 2025	$1,223,426	January 15, 2024	December 31, 2028	MATHEWS, PAUL JAMES	reporter.nih.gov
Mechanisms of Plk1 at the mitotic centromere	NIH	National Institute of General Medical Sciences	2021 to 2024	$1,222,450	April 1, 2021	March 31, 2025	WEAVER, BETH A	reporter.nih.gov
Mechanisms of genetic variants in TH2 autoimmunity	NIH	National Institute of Allergy and Infectious Diseases	2024 to 2025	$1,212,458	July 5, 2024	May 31, 2029	GORONZY, JORG J	reporter.nih.gov
Combined Photoacoustic and Ultrasound Imaging for Enabling Quantitative Evaluation of Hidradenitis Suppurativa	NIH	National Institute of Arthritis and Musculoskeletal and Skin Diseases	2024 to 2025	$1,207,758	March 15, 2024	January 31, 2028	AVANAKI, KAMRAN	reporter.nih.gov
Defining the mechanistic basis of ATM’s impact on VDJ recombination	NIH	National Institute of Allergy and Infectious Diseases	2021 to 2024	$1,162,500	May 20, 2019	April 30, 2026	MEEK, KATHERYN D	reporter.nih.gov
LUBAC-dependent regulation of cell death	NIH	National Institute of General Medical Sciences	2022 to 2025	$1,153,501	September 1, 2021	May 31, 2026	LOPEZ-MOSQUEDA, JAIME	reporter.nih.gov
Molecular and cellular mechanisms in cardiac outflow tract formation and defects	NIH	National Heart, Lung, and Blood Institute	2024	$1,107,221	September 1, 2021	August 31, 2025	ZHOU, BIN	reporter.nih.gov
Mitochondrial influences on blood brain barrier function and neuropsychiatric illness	NIH	National Institute of Mental Health	2024 to 2025	$1,100,197	April 1, 2024	October 31, 2027	ALVAREZ, JORGE IVAN	reporter.nih.gov
Efficacy and mechanisms of anti-IFN drugs in AGS treatment	NIH	National Institute of Neurological Disorders and Stroke	2024 to 2025	$1,079,864	February 1, 2024	January 31, 2029	BILLIAR, TIMOTHY R	reporter.nih.gov
Genomic Clinical Variant Expert Curation Panel for Monogenic Diabetes: A Gateway to Precision Medicine in Diabetes Mellitus	NIH	Eunice Kennedy Shriver National Institute of Child Health & Human Development	2023 to 2025	$1,042,875	June 1, 2023	May 31, 2026	POLLIN, TONI I.	reporter.nih.gov
Leveraging a novel human inborn error of immunity to understand B cell development and function	NIH	National Institute of Allergy and Infectious Diseases	2024 to 2025	$1,028,494	July 2, 2024	May 31, 2029	MARKLE, JANET G	reporter.nih.gov
The adaptor protein Crk in immune responses	NIH	National Institute of Allergy and Infectious Diseases	2024 to 2025	$1,006,108	February 13, 2018	January 31, 2029	LIU, DONGFANG	reporter.nih.gov
Analyzing Genes for Autoimmune Thyroiditis and Diabetes: Translation to Therapy	NIH	National Institute of Diabetes and Digestive and Kidney Diseases	2021 to 2025	$981,321	March 1, 2005	November 30, 2029	TOMER, YARON	reporter.nih.gov
Novel sources of endogenous DNA damage in hematopoietic stem progenitor cells	NIH	National Heart, Lung, and Blood Institute	2021 to 2024	$942,040	September 20, 2021	February 28, 2025	JUNG, MOONJUNG	reporter.nih.gov
Molecular Basis of Coats Plus Disease	NIH	National Institute of General Medical Sciences	2024 to 2025	$910,185	January 1, 2023	December 31, 2026	CHAI, WEIHANG	reporter.nih.gov
Mechanisms of Chromosome Shattering from Defective DNA Replication	NIH	National Cancer Institute	2024 to 2025	$903,640	April 1, 2024	March 31, 2029	LY, PETER	reporter.nih.gov
Human ISG15 and USP18 Deficiencies Underlying Type I Interferonopathies	NIH	National Institute of Allergy and Infectious Diseases	2024 to 2025	$897,474	April 16, 2024	May 31, 2027	BOGUNOVIC, DUSAN	reporter.nih.gov
2/2 - Neurodevelopmental Trajectories in 22q11.2 Deletion Syndrome in Adolescence and Young Adulthood	NIH	National Institute of Mental Health	2024 to 2025	$895,979	February 13, 2024	December 31, 2028	MCDONALD-MCGINN, DONNA MARIE	reporter.nih.gov
The role of cortisol synthesis in pathogenesis of Hidradenitis suppurativa tunnels	NIH	National Institute of Arthritis and Musculoskeletal and Skin Diseases	2024 to 2025	$885,777	September 2, 2024	July 31, 2029	TOMIC-CANIC, MARJANA	reporter.nih.gov
Determining the Genetic Basis of Hidradenitis Suppurativa	NIH	National Institute of Arthritis and Musculoskeletal and Skin Diseases	2024 to 2025	$855,689	August 22, 2024	July 31, 2029	SAYED, CHRISTOPHER J	reporter.nih.gov
Role of the brain-immune axis in neuropsychiatric disease	NIH	National Institute of Mental Health	2024 to 2025	$831,339	November 15, 2023	October 31, 2028	ALVAREZ, JORGE IVAN	reporter.nih.gov
Use of Tiered Genetic Sequencing and Specialty Referral for Identifying and Managing Rare Genetic Causes of Chronic Suppurative Respiratory Disease	NIH	National Heart, Lung, and Blood Institute	2024 to 2025	$826,852	January 15, 2024	December 31, 2027	OLIVIER, KENNETH N.	reporter.nih.gov
Genetic determinates of SPI1 expression and activity in human germinal center B cells	NIH	National Institute of Allergy and Infectious Diseases	2025	$820,623	February 1, 2025	January 31, 2030	ROMBERG, NEIL DAVID	reporter.nih.gov
CRISPR Editing of Primary Human Cells to Model and Correct Primary Immunodeficiency Mutations	NIH	National Institute of Allergy and Infectious Diseases	2021 to 2024	$794,940	July 1, 2020	June 30, 2025	NGUYEN, DAVID-HUY NHU	reporter.nih.gov
Genetic, Immunologic and Mechanistic Basis of Human NK Cell Deficiency	NIH	National Institute of Allergy and Infectious Diseases	2025	$789,847	January 19, 2016	August 31, 2026	ORANGE, JORDAN SCOTT	reporter.nih.gov
Regulation of coagulation and thrombosis by C1 inhibitor	NIH	National Heart, Lung, and Blood Institute	2025	$788,721	August 1, 2025	July 31, 2029	GROVER, STEVEN P.	reporter.nih.gov
The molecular circuits controlling human T follicular regulatory cell development	NIH	National Institute of Allergy and Infectious Diseases	2025	$781,685	December 9, 2024	November 30, 2029	ROMBERG, NEIL DAVID	reporter.nih.gov
Differential regulation of cell cycle entry and apoptosis in cytolytic lymphocytes informed by primary immunodeficiency	NIH	National Institute of Allergy and Infectious Diseases	2025	$764,591	August 1, 2025	July 31, 2030	MACE, EMILY MARGARET	reporter.nih.gov
Ribosomal RNA modification in nucleoli and disease	NIH	National Heart, Lung, and Blood Institute	2024	$755,156	September 13, 2024	August 31, 2025	MEIER, U THOMAS	reporter.nih.gov
Pain in Hidradenitis Suppurativa: Phenotypes and Stakeholder Perspectives	NIH	National Institute of Arthritis and Musculoskeletal and Skin Diseases	2022 to 2025	$743,903	July 8, 2022	June 30, 2027	ORENSTEIN, LAUREN ANNE VIGIL	reporter.nih.gov
Cooperative dysfunction of thalamocortical and cerebellar inputs to the auditory cortex in 22q11.2 deletion syndrome model of schizophrenia.	NIH	National Institute of Mental Health	2025	$731,035	June 1, 2025	March 31, 2030	ZAKHARENKO, STANISLAV S	reporter.nih.gov
Mechanisms of control of allergic skin inflammation by T regulatory cells	NIH	National Institute of Allergy and Infectious Diseases	2025	$716,281	July 24, 2025	June 30, 2030	GEHA, RAIF SALIM	reporter.nih.gov
Understanding Cardiac Mitochondrial Quality Control Through the Lens of Barth Syndrome	NIH	National Heart, Lung, and Blood Institute	2025	$704,913	May 1, 2025	February 28, 2029	VERNON, HILARY	reporter.nih.gov
Genetic Dissection of Stress Responses in Shwachman-Diamond Syndrome	NIH	National Institute of Diabetes and Digestive and Kidney Diseases	2023 to 2025	$701,158	June 22, 2023	May 31, 2026	COREY, SETH JOEL	reporter.nih.gov
Establishing the contributions of monogenic etiologies to hidradenitis suppurativa pathogenesis	NIH	National Institute of Arthritis and Musculoskeletal and Skin Diseases	2024	$700,744	June 1, 2024	May 31, 2029	PETUKHOVA, LYNN	reporter.nih.gov
Regulation of coagulation and thrombosis by C1 inhibitor	NIH	National Heart, Lung, and Blood Institute	2024	$685,884	September 1, 2024	July 31, 2029	GROVER, STEVEN P.	reporter.nih.gov
The role of Rpl5 haploinsufficiency in hematopoietic stem/progenitor cell function in Diamond Blackfan anemia	NIH	National Institute of Diabetes and Digestive and Kidney Diseases	2022 to 2025	$679,740	March 1, 2022	February 28, 2027	SINGH, SHARON A	reporter.nih.gov
Causes and consequences of Blm-dependent DNA replication challenges	NIH	National Institute of General Medical Sciences	2022 to 2025	$675,000	September 1, 2022	August 31, 2027	STOFFREGEN, ERIC PAUL	reporter.nih.gov
Preparing for a Clinical Trial in Kabuki Syndrome- Characterization of Cognitive and Neuroanatomical Features and Pilot Treatment Trial	NIH	Eunice Kennedy Shriver National Institute of Child Health & Human Development	2021 to 2024	$673,942	July 20, 2020	June 30, 2025	HARRIS, JACQUELINE	reporter.nih.gov
Modeling CHARGE Syndrome with Human Inner Ear Organoids	NIH	National Institute on Deafness and Other Communication Disorders	2025	$670,318	December 1, 2024	November 30, 2029	HASHINO, ERI	reporter.nih.gov
Developing Innovative Cell and Gene Therapy Strategies to Treat Fanconi Anemia	NIH	National Heart, Lung, and Blood Institute	2025	$662,949	September 15, 2025	June 30, 2030	CZECHOWICZ, AGNIESZKA	reporter.nih.gov
A generic and immunological investigation of JAK-STAT in the pathogenesis of Celiac	NIH	National Institute of Diabetes and Digestive and Kidney Diseases	2022 to 2025	$661,824	September 1, 2021	April 30, 2026	KONG, XIAO-FEI	reporter.nih.gov
Chronic STAT3 signaling in STAT3 GOF causes CD8 T cell dysfunction via CD39 upregulation	NIH	National Institute of Allergy and Infectious Diseases	2025	$658,426	December 20, 2024	November 30, 2029	HENRICKSON, SARAH E	reporter.nih.gov
Donor Red Blood Cell Survival in Recipients with Sickle Cell Disease	NIH	National Heart, Lung, and Blood Institute	2025	$646,383	September 15, 2025	June 30, 2030	YEE, MARIANNE ELAINE MCPHERSON	reporter.nih.gov
Ribosomes and growth regulation	NIH	National Institute of General Medical Sciences	2024 to 2025	$628,000	September 8, 2016	August 31, 2027	BAKER, NICHOLAS E	reporter.nih.gov
Uncovering Novel Regulatory Pathways and Functions of the Telomerase RNA Component in the Hematopoietic System	NIH	National Heart, Lung, and Blood Institute	2025	$623,874	December 15, 2024	November 30, 2025	BATISTA, LUIS FRANCISCO ZIRNBERGER	reporter.nih.gov
Leveraging human iPSC technology to understand the role of neuroinflammation in 22q11.2 deletion syndrome	NIH	National Institute of Mental Health	2025	$610,784	April 4, 2025	January 31, 2030	WEN, ZHEXING	reporter.nih.gov
Hematopoietic consequences of gain-of-function SAMD9 and SAMD9L mutations	NIH	National Heart, Lung, and Blood Institute	2021 to 2024	$594,864	November 1, 2020	January 31, 2025	SCHWARTZ, JASON ROSS	reporter.nih.gov
A C. Elegans Model of Fanconi Anemia Neurological Syndrome	NIH	National Institute of Neurological Disorders and Stroke	2025	$544,854	June 1, 2025	May 31, 2028	HOWLETT, NIALL GEORGE	reporter.nih.gov
Glutathione reductase (Gsr) regulates cell metabolism and signaling during neutrophil-pathogen interactions	NIH	National Institute of Allergy and Infectious Diseases	2025	$527,960	August 18, 2025	July 31, 2030	LIU, YUSEN	reporter.nih.gov
Mechanism of inflammation in deficiency of adenosine deaminase 2	NIH	National Institute of Allergy and Infectious Diseases	2025	$522,524	July 25, 2025	June 30, 2030	LEE, PUI YUEN	reporter.nih.gov
Multilevel factors influencing racial, ethnic, and socioeconomic disparities in hidradenitis suppurativa	NIH	National Institute of Arthritis and Musculoskeletal and Skin Diseases	2023 to 2025	$501,876	September 15, 2023	August 31, 2028	CHANG, AILEEN YENTING	reporter.nih.gov
Targeting the immunoproteasome as a novel therapeutic strategy for hemophagocytic lymphohistiocytosis	NIH	National Institute of Allergy and Infectious Diseases	2023 to 2024	$500,500	July 5, 2023	June 30, 2026	NICHOLS, KIM ERIKA	reporter.nih.gov
miRNA buffering mechanisms and phenotypic variability in genetic syndromes	NIH	Eunice Kennedy Shriver National Institute of Child Health & Human Development	2024 to 2025	$500,500	July 17, 2024	June 30, 2026	ZOHN, IRENE E	reporter.nih.gov
Inborn Errors of Immunity Leading to Autoinflammatory Syndromes	NIH	National Institute of Allergy and Infectious Diseases	2024	$498,911	April 20, 2024	June 30, 2025	BOGUNOVIC, DUSAN	reporter.nih.gov
Genetic Variants of Immune Dysregulation and Thrombotic Microangiopathy in Severe Pediatric Sepsis Induced Organ Dysfunction	NIH	National Institute of General Medical Sciences	2023 to 2025	$489,244	June 1, 2023	May 31, 2027	KERNAN, KATHRYN MARY	reporter.nih.gov
Antigen specificity of plasma cells in Hidradenitis suppurativa skin lesions	NIH	National Institute of Allergy and Infectious Diseases	2024 to 2025	$482,076	July 17, 2024	May 31, 2027	JACOB, JOSHY	reporter.nih.gov
Mitochondrial mechanisms underlying neural stem and progenitor cell proliferation deficits in 22q11.2 deletion syndrome	NIH	National Institute of Neurological Disorders and Stroke	2024 to 2025	$462,510	March 1, 2024	February 28, 2029	CAMPBELL, PHILIP	reporter.nih.gov
Validating interferon score and phospho-STING level as disease biomarkers of COPA syndrome	NIH	National Center for Advancing Translational Sciences	2025	$462,188	July 17, 2025	June 30, 2027	SHUM, ANTHONY	reporter.nih.gov
Investigating abnormalities in top-down cortical processing and behavior in a model of the 22q11.2 deletion	NIH	National Institute of Mental Health	2023 to 2024	$462,000	May 1, 2023	April 30, 2025	BATISTA-BRITO, RENATA	reporter.nih.gov
Radioresistant Innate Immunity in SAVI Tissue-Specific Autoinflammation	NIH	National Institute of Allergy and Infectious Diseases	2023 to 2024	$460,625	August 4, 2023	July 31, 2025	MARSHAK-ROTHSTEIN, ANN	reporter.nih.gov
Vaccine-induced SARS-CoV-2-specific T cell responses in patients with X-linked Agammaglobulinemia	NIH	National Institute of Allergy and Infectious Diseases	2023 to 2024	$445,633	January 9, 2023	December 31, 2025	DE PARIS, KRISTINA	reporter.nih.gov
Novel mitochondria-targeting peptides (MTPs) as therapeutic intervention in Barth syndrome	NIH	National Heart, Lung, and Blood Institute	2025	$445,500	January 15, 2025	December 31, 2027	SANDLERS, YANA I	reporter.nih.gov
Mechanisms of Impaired Granulopoiesis Due to CLPB Mutations	NIH	National Heart, Lung, and Blood Institute	2025	$445,000	July 1, 2025	June 30, 2028	WARREN, JULIA THERESE	reporter.nih.gov
Mechanism of radial chromosome formation in human premature aging syndrome cells	NIH	National Institute on Aging	2023 to 2024	$444,124	December 1, 2022	November 30, 2024	HENDRICKSON, ERIC A	reporter.nih.gov
Utilization of JAK inhibitor therapy in a transplant model of STAT1 GOF disease	NIH	National Institute of Allergy and Infectious Diseases	2025	$441,375	August 22, 2025	July 31, 2027	FORBES, LISA	reporter.nih.gov
FOXN1 variant regulation of T cell production	NIH	National Institute of Allergy and Infectious Diseases	2025	$436,466	July 2, 2025	June 30, 2027	VAN OERS, NICOLAI STANISLAS CYRILLE	reporter.nih.gov
FANCC mutation correction using homology-independent targeted integration for gene therapy of Fanconi Anemia group C	NIH	National Heart, Lung, and Blood Institute	2023 to 2024	$435,875	July 15, 2023	June 30, 2025	TRAN, NGOC TUNG	reporter.nih.gov
Investigation of a Novel Inborn Error of Immunity with B Cell Deficiency	NIH	National Institute of Allergy and Infectious Diseases	2024 to 2025	$421,794	December 12, 2023	October 31, 2025	COOPER, MEGAN ANNE	reporter.nih.gov
Genetic Variation and Inflammation-Dependent Hematopoietic Regulatory Networks	NIH	National Institute of Allergy and Infectious Diseases	2024 to 2025	$421,794	January 1, 2024	November 30, 2025	BRESNICK, EMERY H.	reporter.nih.gov
In vivo and ex vivo gene editing for Artemis-deficient SCID	NIH	National Institute of Allergy and Infectious Diseases	2025	$420,771	July 7, 2025	June 30, 2027	MCIVOR, R. SCOTT	reporter.nih.gov
New insight into innate immune regulation through mechanistic studies of a novel oligoadenylate synthetase-like (OASL) gain-of-function variant	NIH	National Institute of Allergy and Infectious Diseases	2024 to 2025	$419,075	June 1, 2024	April 30, 2027	CONN, GRAEME L	reporter.nih.gov
Molecular mechanisms of ribosome biogenesis by force-producing enzymes	NIH	National Institute of General Medical Sciences	2025	$392,500	January 1, 2025	December 31, 2029	MICKOLAJCZYK, KEITH JOSEPH	reporter.nih.gov
Mechanisms of Impaired Granulopoiesis Due to CLPB Mutations	NIH	National Heart, Lung, and Blood Institute	2022 to 2024	$390,017	July 1, 2021	June 30, 2025	WARREN, JULIA THERESE	reporter.nih.gov
Rewiring of RNA Polymerase II in a Novel Taspase1- Mediated Marrow Failure.	NIH	National Institute of Diabetes and Digestive and Kidney Diseases	2025	$390,000	September 15, 2025	June 30, 2030	FORESTER, CRAIG M.	reporter.nih.gov
Mechanisms Contributing to T Cell Immune Dysregulation in STAT3 Gain-of-Function	NIH	National Institute of Allergy and Infectious Diseases	2024 to 2025	$389,412	August 6, 2024	July 31, 2029	SCHMITT, ERICA G	reporter.nih.gov
Crosstalk of Immune Dysregulation and Impaired Wound Healing in inherited STAT4-mediated Autoinflammatory Disease	NIH	National Institute of Allergy and Infectious Diseases	2025	$385,575	February 1, 2025	January 31, 2030	BRODERICK, LORI	reporter.nih.gov
Protection of hematopoietic stem progenitor cells from endogenous DNA damage	NIH	National Heart, Lung, and Blood Institute	2025	$380,383	April 21, 2025	March 31, 2028	JUNG, MOONJUNG	reporter.nih.gov
Bespoke Micellar Nanoparticles (MNPs) for In Vivo Delivery of Digital Base Editor Treatments for Primary Immunodeficiency Disease	NIH	National Institute of Allergy and Infectious Diseases	2025	$380,000	September 11, 2025	August 31, 2026	REINEKE, THERESA M	reporter.nih.gov
Impact of novel, non-classical type I interferon in HS pathophysiology	NIH	National Institute of Arthritis and Musculoskeletal and Skin Diseases	2025	$366,053	August 1, 2025	June 30, 2027	NELSON, AMANDA MARIE	reporter.nih.gov
Active non-viral nuclear delivery of DNA templates independent of mitosis	NIH	National Institute of General Medical Sciences	2025	$349,952	September 1, 2025	August 31, 2026	ENGELHARDT, FLORIS ALASKA SILVIA	reporter.nih.gov
BMT Core - Pediatric Transplantation and Cellular Therapy Consortium (PTCTC): Providing Clinical Trial Access For Children With Life Threatening Diseases	NIH	National Heart, Lung, and Blood Institute	2024 to 2025	$349,037	August 15, 2024	June 30, 2031	STEFANSKI, HEATHER E	reporter.nih.gov
Role of GM-CSF and impaired lipid metabolism in the pathogenesis of PAP	NIH	National Heart, Lung, and Blood Institute	2024 to 2025	$341,064	September 18, 2024	July 31, 2029	LEE, ELINOR	reporter.nih.gov
Targeting cutaneous nociceptors to reduce Type-17 inflammation in hidradenitis suppurativa	NIH	National Institute of Arthritis and Musculoskeletal and Skin Diseases	2024 to 2025	$336,916	May 1, 2024	April 30, 2028	WHITLEY, SARAH KERN	reporter.nih.gov
Insights from somatic genomics lead to novel therapeutic targets in inherited bone marrow failure syndromes: Shwachman-Diamond Syndrome as a model	NIH	National Institute of Diabetes and Digestive and Kidney Diseases	2024 to 2025	$336,722	July 1, 2021	March 31, 2026	KENNEDY, ALYSSA	reporter.nih.gov
Anti-CD38 isatuximab Immunotherapy in Hidradenitis Suppurativa: a randomized, double-blinded, placebo-controlled, seamless phase 2a/2b trial	NIH	National Institute of Arthritis and Musculoskeletal and Skin Diseases	2025	$333,625	August 1, 2025	August 31, 2026	MI, QING-SHENG	reporter.nih.gov
Using Bioinformatics Methodologies to Explore the Role of Short Interspersed Elements in the Pathogenesis of Idiopathic Inflammatory Myopathies	NIH	National Institute of Arthritis and Musculoskeletal and Skin Diseases	2024 to 2025	$329,616	April 1, 2024	March 31, 2029	NAJJAR, RAYAN	reporter.nih.gov
G6PD Deficiency and Atherosclerosis	NIH	National Heart, Lung, and Blood Institute	2025	$323,000	March 4, 2025	December 31, 2027	MCNAMARA, COLEEN A	reporter.nih.gov
Gene Regulatory Mechanisms of Mll4 in Tooth Enamel Development	NIH	National Institute of Dental & Craniofacial Research	2025	$320,200	July 15, 2025	July 14, 2027	LEE, JUNG-MI	reporter.nih.gov
Testing MALT1 inhibitors as a treatment for the rare pediatric inborn error of immunity CARD11 gain of function	NIH	National Institute of Allergy and Infectious Diseases	2025	$313,176	September 22, 2025	February 28, 2027	HOU, ANDREW	reporter.nih.gov
Evaluating a Novel Enzymatic Modality for the Treatment of Fanconi Anemia	NIH	National Heart, Lung, and Blood Institute	2024	$306,870	August 20, 2024	July 31, 2026	CAO, MINGJU	reporter.nih.gov
Preclinical Development of LCTG-001, a Human Secretory IgA Replacement Therapy for CVID Patients	NIH	National Institute of Allergy and Infectious Diseases	2025	$304,629	January 24, 2025	December 31, 2025	MANE, VIRAJ PRAMOD	reporter.nih.gov
Development of sIgA from human milk as a therapeutic for Inflammatory bowel disease	NIH	National Institute of Diabetes and Digestive and Kidney Diseases	2025	$303,427	September 1, 2025	August 31, 2026	MANE, VIRAJ PRAMOD	reporter.nih.gov
In vivo targeted delivery of nucleic acids to hematopoietic stem cells for treating primary immunodeficiencies	NIH	National Institute of Allergy and Infectious Diseases	2025	$300,000	August 19, 2025	July 31, 2027	CHUNG, ALLEN	reporter.nih.gov
Safety of AAV-mediated C1 Esterase Inhibitor Gene Therapy for Hereditary Angioedema	NIH	National Institute of Allergy and Infectious Diseases	2024	$275,737	March 15, 2024	November 30, 2025	CRYSTAL, RONALD G	reporter.nih.gov
Mitochondrial influences on blood brain barrier function and neuropsychiatric illness	NIH	National Institute of Mental Health	2024	$257,399	November 20, 2023	March 31, 2024	ALVAREZ, JORGE IVAN	reporter.nih.gov
A novel circuit underlying amotivation in a mouse model of 22q11DS	NIH	National Institute of Mental Health	2025	$249,000	December 12, 2022	May 31, 2028	PATTON, MARY H.	reporter.nih.gov
A Proactive Missense Variant Atlas for the Autoimmune Regulator	NIH	National Institute of Allergy and Infectious Diseases	2024	$238,500	February 13, 2023	January 31, 2025	ROTH, FREDERICK P	reporter.nih.gov
Non-genotoxic HSCT for ATM	NIH	National Heart, Lung, and Blood Institute	2024 to 2025	$234,750	September 1, 2024	August 31, 2026	CHANDRAKASAN, SHANMUGANATHAN	reporter.nih.gov
Modulation of neutrophil-endothelial interactions by ADAM10	NIH	National Institute of Allergy and Infectious Diseases	2025	$226,253	January 23, 2025	December 31, 2026	BUBECK WARDENBURG, JULIANE	reporter.nih.gov
Autologous Non-viral CRISPR/Cas Homology-directed Repair for Artemis-deficient Severe Combined Immunodeficiency	NIH	National Institute of Allergy and Infectious Diseases	2025	$200,016	May 8, 2025	April 30, 2030	KAN, MATTHEW J	reporter.nih.gov
The role of GATA2 in myeloid malignancies and MonoMAC syndrome	NIH	National Cancer Institute	2025	$194,688	January 1, 2025	December 31, 2027	KATERNDAHL, CASEY DUNCAN SAUL	reporter.nih.gov
Hematopoietic stem cell defects in Diamond-Blackfan Anemia	NIH	National Institute of Diabetes and Digestive and Kidney Diseases	2024 to 2025	$179,880	April 1, 2024	March 31, 2026	BHOOPALAN, SENTHIL VELAN	reporter.nih.gov
A novel circuit underlying amotivation in a mouse model of 22q11DS	NIH	National Institute of Mental Health	2023 to 2024	$176,748	December 12, 2022	November 30, 2024	PATTON, MARY H.	reporter.nih.gov
Use of NLP to Extract Risk Indicators for Immunologic Disease from the Text of EHRs (UNIITE)	NIH	National Institute of Allergy and Infectious Diseases	2024	$169,779	February 18, 2022	January 31, 2026	RIDER, NICHOLAS L	reporter.nih.gov
Control of multilineage hematopoiesis by 5' cap-proximal modification	NIH	National Heart, Lung, and Blood Institute	2025	$164,160	August 1, 2025	May 31, 2030	LEVINE, ANDREW	reporter.nih.gov
A somatic hypermutation defective UNG mutant in antibody deficiency through destabilization of RPA interaction.	NIH	National Institute of Allergy and Infectious Diseases	2024 to 2025	$162,000	June 1, 2024	April 30, 2027	MCBRIDE, KEVIN MICHAEL	reporter.nih.gov
Genome-wide dysregulation of R-loops in Ataxia Telangiectasia neurological pathogenesis	NIH	National Institute of Neurological Disorders and Stroke	2023 to 2025	$141,408	March 13, 2023	January 12, 2026	WESTOVER, KATHERINE R.	reporter.nih.gov
Investigating the role of telomere failure on intestinal stem cell niche function	NIH	National Institute of Diabetes and Digestive and Kidney Diseases	2023 to 2025	$134,028	August 1, 2023	July 31, 2026	KIM, MELISSA	reporter.nih.gov
Non-canonical roles for ATM kinase in regulating mitochondrial function and redox homeostasis	NIH	National Cancer Institute	2022 to 2024	$126,223	June 1, 2022	May 31, 2025	BURRELL, PAIGE ELIZABETH	reporter.nih.gov
An Engineered Hydrogel Platform to Improve Neural Organoid Reproducibility for a Multi-Organoid Disease Model of 22q11.2 Deletion Syndrome	NIH	National Institute of Neurological Disorders and Stroke	2023 to 2025	$113,017	June 16, 2023	December 15, 2025	HUANG, MICHELLE S	reporter.nih.gov
Investigation of Chromatin Modifiers to Elucidate the Phenotypic Variability of Congenital Heart Disease in Patients with 22q11.2 Deletion Syndrome	NIH	National Heart, Lung, and Blood Institute	2024 to 2025	$108,512	January 16, 2024	July 15, 2027	MILLER, DANIELLA	reporter.nih.gov
Mapping functional brain connectivity, neurodevelopment, and imaging-genetic associations in individuals with genetic and clinical risk factors for neuropsychiatric illness	NIH	National Institute of Mental Health	2023 to 2024	$93,721	September 1, 2023	August 31, 2025	SCHLEIFER, CHARLES	reporter.nih.gov
The Role of Monoallelic Expression in Incomplete Penetrance of Primary Immunodeficiencies	NIH	National Institute of Allergy and Infectious Diseases	2023 to 2024	$85,521	June 22, 2023	December 22, 2024	STEWART, O'JAY	reporter.nih.gov
Identification of biologically relevant subtypes of hidradenitis suppurativa	NIH	National Institute of Arthritis and Musculoskeletal and Skin Diseases	2024	$83,905	June 1, 2024	May 31, 2026	PETUKHOVA, LYNN	reporter.nih.gov
Enhancer Hijacking of the IgH Locus as a Novel Genetic Mechanism of Inborn Errors of Immunity	NIH	National Institute of Allergy and Infectious Diseases	2024 to 2025	$68,733	August 1, 2024	June 30, 2026	TOBIN, JOSHUA	reporter.nih.gov
A novel genetic mutation reveals the molecular and cellular mechanisms of severe recurrent skin inflammation	NIH	National Institute of Arthritis and Musculoskeletal and Skin Diseases	2023 to 2024	$67,220	April 1, 2023	March 31, 2025	GIL, HWI (DEBORAH) M	reporter.nih.gov
Annual Primary Immune Deficiency Treatment Consortium (PIDTC) Workshop and Education Day	NIH	National Institute of Allergy and Infectious Diseases	2023 to 2025	$60,000	March 8, 2011	February 28, 2026	PUCK, JENNIFER M.	reporter.nih.gov
Dysregulation of Gamma Secretase in Common Acquired Hidradenitis Suppurativa	NIH	National Institute of Allergy and Infectious Diseases	2025	$54,538	May 15, 2025	May 14, 2028	MINSKY, HANA BLEICHER	reporter.nih.gov
Understanding how defects in the maternal epigenetic reprogramming function of LSD1/KDM1A contribute to inherited phenotypes	NIH	Eunice Kennedy Shriver National Institute of Child Health & Human Development	2025	$49,538	April 1, 2025	March 31, 2028	REEVES, MONICA	reporter.nih.gov
Determining the function of Tbx1 in the pharyngeal endoderm for aortic arch development	NIH	National Heart, Lung, and Blood Institute	2025	$49,538	June 16, 2025	June 15, 2028	JACKSON, KEVYN E	reporter.nih.gov
Investigating the roles of the H3K4 methyltransferases KMT2C and KMT2D in chondrocyte differentiation and endochondral ossification	NIH	National Institute of Dental & Craniofacial Research	2024	$43,374	August 1, 2024	October 31, 2026	QUICKSTAD, GABRIELLE ALAIR	reporter.nih.gov
Influence of Maternal IgA on Neonatal iNKT Cell Development and Gluten Sensitive Enteropathy.	NIH	National Institute of Allergy and Infectious Diseases	2025	$41,778	May 15, 2025	May 14, 2028	BALL, RYAN ALBERT WILLIAM	reporter.nih.gov
2024 Scientific and Medical Conference on Barth Syndrome: Benchtop to Treatments	NIH	National Heart, Lung, and Blood Institute	2024	$40,000	August 1, 2024	July 31, 2025	GREENBERG, MIRIAM L	reporter.nih.gov
Linking GATA2 deficiency to innate immune signaling	NIH	National Institute of Diabetes and Digestive and Kidney Diseases	2024	$36,306	December 1, 2024	April 28, 2025	TRAN, VU LE-HUY	reporter.nih.gov
In vivo hematopoietic stem cell gene therapy in a novel genetically humanized murine model of SCID-A	NIH	National Institute of Allergy and Infectious Diseases	2025	$36,093	September 22, 2025	October 21, 2027	EATON, ELLA JOY	reporter.nih.gov
Single-Cell Analysis of Somatic Mutation Rates, Mechanisms, and Impacts in Human Ataxia Telangiectasia Cerebellum	NIH	National Institute of Neurological Disorders and Stroke	2025	$34,454	May 1, 2025	October 31, 2028	CLASS, BRADLEY	reporter.nih.gov

Organizations

Organization	Place	NIH awards	NIH amount	NSF amount
Rho Federal Systems Division, Inc.	Durham, NC	1	$32.1 million	$0
Children's Hosp of Philadelphia	Philadelphia, PA	13	$21.3 million	$0
University of California, San Francisco	San Francisco, CA	13	$21.2 million	$0
Boston Children's Hospital	Boston, MA	8	$13.2 million	$0
Rockefeller University	New York, NY	5	$12.8 million	$0
Albert Einstein College of Medicine	Bronx, NY	8	$10.3 million	$0
Columbia University Health Sciences	New York, NY	6	$9.4 million	$0
University of Pennsylvania	Philadelphia, PA	8	$9.3 million	$0
Stanford University	Stanford, CA	6	$9.1 million	$0
Univ of North Carolina Chapel Hill	Chapel Hill, NC	7	$7.3 million	$0
Baylor College of Medicine	Houston, TX	4	$6.7 million	$0
University of California Los Angeles	Los Angeles, CA	4	$6.5 million	$0
Univ of Massachusetts Med SCH Worcester	Worcester, MA	5	$6.2 million	$0
ST. Jude Children's Research Hospital	Memphis, TN	7	$6 million	$0
Portland State University	Portland, OR	2	$5.8 million	$0
University of Washington	Seattle, WA	3	$5.6 million	$0
University of Pittsburgh at Pittsburgh	Pittsburgh, PA	5	$5.1 million	$0
Duke University	Durham, NC	3	$5 million	$0
Indiana University Indianapolis	Indianapolis, IN	5	$4.9 million	$0
Washington University	Saint Louis, MO	6	$4.1 million	$0
University of Wisconsin-Madison	Madison, WI	4	$4.1 million	$0
Harvard Medical School	Boston, MA	2	$3.8 million	$0
Ut Southwestern Medical Center	Dallas, TX	4	$3.7 million	$0
Vanderbilt University Medical Center	Nashville, TN	3	$3.6 million	$0
University of Maryland Baltimore	Baltimore, MD	2	$3.4 million	$0
Massachusetts General Hospital	Boston, MA	2	$3.3 million	$0
Emory University	Atlanta, GA	8	$3.3 million	$0
Pennsylvania State Univ Hershey Med CTR	Hershey, PA	3	$3.3 million	$0
Iowa State University	Ames, IA	1	$3.2 million	$0
University of Colorado Denver	Aurora, CO	2	$3.1 million	$0
Yale University	New Haven, CT	1	$2.9 million	$0
University of Minnesota	Minneapolis, MN	4	$2.9 million	$0
Virginia Polytechnic Institute and State University	Blacksburg, VA	2	$2.9 million	$0
University of Georgia Research Foundation Inc	Athens, GA	1	$2.6 million	$0
National Marrow Donor Program	Minneapolis, MN	2	$2.5 million	$0
Harvard Pilgrim Health Care, Inc.	Canton, MA	1	$2.4 million	$0
University of California, San Diego	La Jolla, CA	2	$2.4 million	$0
University of South Florida	Tampa, FL	1	$2.2 million	$0
University of Virginia	Charlottesville, VA	3	$2.2 million	$0
University of TX MD Anderson Can CTR	Houston, TX	2	$2.2 million	$0
Dana-Farber Cancer Inst	Boston, MA	1	$2.2 million	$0
University of Southern California	Los Angeles, CA	1	$2.1 million	$0
New York University School of Medicine	New York, NY	3	$2.1 million	$0
Henry M. Jackson FDN for the Adv Mil/med	Bethesda, MD	1	$2.1 million	$0
Johns Hopkins University	Baltimore, MD	4	$2.1 million	$0
Resvita Bio, Inc.	Berkeley, CA	1	$2 million	$0
Sloan-Kettering Inst Can Research	New York, NY	1	$2 million	$0
Henry Ford Health + Michigan State University Health Sciences	East Lansing, MI	2	$1.9 million	$0
Northwestern University at Chicago	Chicago, IL	1	$1.8 million	$0
Research Inst Nationwide Children's Hosp	Columbus, OH	2	$1.8 million	$0
Brown University	Providence, RI	1	$1.8 million	$0
Versiti Blood Health, Inc.	Milwaukee, WI	1	$1.7 million	$0
California Institute of Technology	Pasadena, CA	1	$1.7 million	$0
Saint Louis University	Saint Louis, MO	1	$1.5 million	$0
Rutgers Biomedical and Health Sciences	Newark, NJ	2	$1.4 million	$0
University of Connecticut	Storrs, CT	1	$1.4 million	$0
Lundquist Institute for Biomedical Innovation at Harbor-Ucla Medical Center	Torrance, CA	1	$1.2 million	$0
Mayo Clinic Rochester	Rochester, MN	1	$1.2 million	$0
University of Illinois at Chicago	Chicago, IL	1	$1.2 million	$0
Michigan State University	East Lansing, MI	1	$1.2 million	$0
University of Texas at Austin	Austin, TX	1	$1.2 million	$0
University of Chicago	Chicago, IL	1	$1.1 million	$0
Rosalind Franklin Univ of Medicine & Sci	North Chicago, IL	1	$910,185	$0
University of Miami School of Medicine	Coral Gables, FL	1	$885,777	$0
Beth Israel Deaconess Medical Center	Boston, MA	1	$788,721	$0
Cleveland Clinic Lerner Com-Cwru	Cleveland, OH	1	$701,158	$0
University of Michigan at Ann Arbor	Ann Arbor, MI	1	$679,740	$0
Lewis-Clark State College	Lewiston, ID	1	$675,000	$0
Hugo W. Moser Res Inst Kennedy Krieger	Baltimore, MD	1	$673,942	$0
University of California-Irvine	Irvine, CA	1	$628,000	$0
Lactiga US Inc.	North Brunswick, NJ	2	$608,056	$0
University of Rhode Island	Kingston, RI	1	$544,854	$0
Children's Research Institute	Washington, DC	1	$500,500	$0
Cleveland State University	Cleveland, OH	1	$445,500	$0
Kano Therapeutics INC	Cambridge, MA	1	$349,952	$0
SUNY at Buffalo	Amherst, NY	1	$320,200	$0
Rarefied Biosciences, Inc.	Santa Monica, CA	1	$313,176	$0
Kinetiq Therapeutics LLC	Fort Worth, TX	1	$306,870	$0
Optimeos Life Sciences, Inc.	Princeton, NJ	1	$300,000	$0
Enyx Therapeutics, LLC	New York, NY	1	$275,737	$0
University of Tennessee Health Sci CTR	Memphis, TN	1	$249,000	$0
Icahn School of Medicine at Mount Sinai	New York, NY	1	$85,521	$0
Vanderbilt University	Nashville, TN	1	$67,220	$0
University of South Carolina at Columbia	Columbia, SC	1	$41,778	$0
Barth Syndrome Foundation	Larchmont, NY	1	$40,000	$0

Funding by fiscal year

Fiscal year	NIH awards	NIH amount	NSF amount
2025	170	$92,393,110	$0
2024	167	$85,631,666	$0
2023	107	$58,631,210	$0
2022	76	$45,825,458	$0
2021	51	$26,547,654	$0

Open federal funding opportunities

From Grants.gov: notices that funded awards in this table, and open notices on the same agency and assistance listing.

Open opportunity	Number	Agency	Listing	Closes	Award ceiling	Why it matches
Change of Recipient Organization (Type 7 Parent Clinical Trial Optional)	PA-24-254	NIH		July 12, 2027	Not listed	Notice number printed on 5 awards here
Mentored Clinical Scientist Research Career Development Award (Parent K08 Independent Clinical Trial Not Allowed)	PA-24-182	NIH		May 8, 2027	Not listed	Notice number printed on 1 award here
Infectious Diseases Clinical Trials Network (IDCTN) (UM1 Clinical Trial Required)	RFA-AI-27-002	NIH	93.855	November 10, 2026	Not listed	Same assistance listing 93.855 as 81 awards here
Clinical Research Network on Antimicrobial Resistance (UM1 Clinical Trial Required)	RFA-AI-27-005	NIH	93.855	November 10, 2026	Not listed	Same assistance listing 93.855 as 81 awards here
Ethical, Legal and Social Implications (ELSI) Small Research Grant (R03 Clinical Trial Optional)	PAR-25-370	NIH	93.855	November 16, 2026	$50,000	Same assistance listing 93.855 as 81 awards here
Ethical, Legal and Social Implications (ELSI) Exploratory/Developmental Research Grant (R21 Clinical Trial Optional)	PAR-25-369	NIH	93.855	November 18, 2026	Not listed	Same assistance listing 93.855 as 81 awards here
Ethical, Legal and Social Implications (ELSI) Research (R01 Clinical Trial Optional)	PAR-25-371	NIH	93.855	November 18, 2026	Not listed	Same assistance listing 93.855 as 81 awards here
Intervention Research to Improve Native American Health (R01 Clinical Trial Optional)	PAR-25-379	NIH	93.855	January 7, 2027	Not listed	Same assistance listing 93.855 as 81 awards here
HIV/AIDS Clinical Trials Network Leadership and Operations Centers	RFA-AI-28-001	NIH	93.855	January 22, 2027	Not listed	Same assistance listing 93.855 as 81 awards here
HIV/AIDS Clinical Trials Network Laboratory Centers	RFA-AI-28-002	NIH	93.855	January 22, 2027	Not listed	Same assistance listing 93.855 as 81 awards here
HIV/AIDS Clinical Trials Network Statistical and Data Management Centers	RFA-AI-28-003	NIH	93.855	January 22, 2027	Not listed	Same assistance listing 93.855 as 81 awards here
HIV/AIDS Clinical Trials Network Clinical Trials Units	RFA-AI-28-004	NIH	93.855	January 22, 2027	Not listed	Same assistance listing 93.855 as 81 awards here
Precision and Systems Biology to Uncover the Link Between Chronic and Infectious Diseases	RFA-AI-28-014	NIH	93.855	January 22, 2027	Not listed	Same assistance listing 93.855 as 81 awards here
Immune Tolerance Network (UM1 Clinical Trial Required)	RFA-AI-28-005	NIH	93.855	January 29, 2027	Not listed	Same assistance listing 93.855 as 81 awards here
Translational Centers Using Microphysiological Systems for Infectious Diseases (U54 Clinical Trial Not Allowed)	RFA-AI-28-012	NIH	93.855	January 29, 2027	Not listed	Same assistance listing 93.855 as 81 awards here
Accelerating Research and Development of Next Generation Vaccines against Malaria - a Model for Mosquito-Borne Diseases (R61/R33 Clinical Trial Not Allowed)	RFA-AI-28-024	NIH	93.855	February 11, 2027	Not listed	Same assistance listing 93.855 as 81 awards here
NLM Institutional Grants for Research Training in Biomedical Informatics, Data Science, and AI (T15 Independent Clinical Trial Not Allowed)	RFA-LM-28-001	NIH	93.855	February 11, 2027	$775,000	Same assistance listing 93.855 as 81 awards here
NIH, CDC and FDA Small Business Innovation Research Grant (Parent SBIR [R43/R44] Clinical Trial Optional)	PA-27-100	NIH	93.855	April 5, 2027	Not listed	Same assistance listing 93.855 as 81 awards here
NIH Small Business Technology Transfer Grant (Parent STTR [R41/R42] Clinical Trial Optional)	PA-27-102	NIH	93.855	April 5, 2027	Not listed	Same assistance listing 93.855 as 81 awards here
Mentored Research Scientist Development Award (Parent K01 - Independent Clinical Trial Not Allowed)	PA-24-176	NIH	93.855	May 7, 2027	Not listed	Same assistance listing 93.855 as 81 awards here

Updated November 3, 2026. Read from NIH RePORTER ExPORTER and NSF Award Search. Published by NIH and NSF as U.S. government data. NIH awards are fiscal years 2021 to 2025 (NIH files published to 2026-07-09); NSF awards are fiscal years 2022 to 2026 (NSF files published to 2026-11-02). NIH amounts are the total cost of each fiscal year in the window; NSF amounts are the funds obligated in the window. Organizations are matched on the UEI. Open opportunities come from Grants.gov and match on agency and assistance listing number, and on the notice number NIH prints on an award. Free to reuse with credit to SpecStream under CC BY 4.0. Spot a wrong value? Write to [email protected] with the link to this page.