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Data / Research funding / Parkinson's Disease

Parkinson's Disease: 854 NIH awards ($952.4M) to 209 organizations

854 NIH awards ($952.4M) in the NIH spending category Parkinson's Disease, to 209 organizations, read 2026-11-03. NIH fiscal years 2021 to 2025.

SpecStream is the live web data engine for teams and agents. It reads the NIH and NSF award files each time the agencies update them, and this page is that reading, joined to the open federal funding opportunities on Grants.gov. Ask for the awards you track by topic, organization or state and new awards arrive in your sheet, CRM, Slack or agent as the agencies publish them.

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Awards

The 500 largest of 854 awards in the window.

AwardAgencyInstitute or divisionFiscal yearAmount in windowStartEndPrincipal investigatorSource
Prevention of Fractures in Patients with Parkinson's DiseaseNIHNational Institute on Aging2022 to 2024$13,269,734September 30, 2018February 28, 2026CUMMINGS, STEVEN RONreporter.nih.gov
Study in Parkinson Disease of Exercise Phase 3 Clinical Trial: SPARX3NIHNational Institute of Neurological Disorders and Stroke2023 to 2025$13,006,073September 25, 2019July 31, 2026CORCOS, DANIEL M.reporter.nih.gov
Parkinsons Disease Scalable iPSC Autologous Cell TherapyNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$7,528,144January 1, 2020December 31, 2025HALLETT, PENELOPE JANEreporter.nih.gov
Dementia with Lewy Bodies ConsortiumNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$6,563,373September 30, 2016August 31, 2027LEVERENZ, JAMES BRUCEreporter.nih.gov
Mechanistic Analysis of Genetic Modifiers in Parkinson's DiseaseNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$5,598,826May 1, 2021April 30, 2029KRAINC, DIMITRIreporter.nih.gov
Novel Protein Biomarkers of Corticolimbic Pathophysiology in Lewy body DementiaNIHNational Institute of Neurological Disorders and Stroke2022 to 2024$4,943,234September 15, 2022June 30, 2027SEYFRIED, NICHOLAS THOMASreporter.nih.gov
Web-based Automated Imaging Differentiation of ParkinsonismNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$4,837,150April 1, 2021March 31, 2027VAILLANCOURT, DAVID Ereporter.nih.gov
Achieving specificity in imaging neurodegeneration with visible light Optical Coherence TomographyNIHOffice of the Director, National Institutes of Health2024 to 2025$4,798,178September 15, 2024September 14, 2027SRINIVASAN, VIVEK JAYreporter.nih.gov
Structural Biology of Alpha-Synuclein in Lewy Body DementiaNIHNational Institute of Neurological Disorders and Stroke2023$4,231,530September 30, 2018August 31, 2026KOTZBAUER, PAUL Treporter.nih.gov
Dissecting Oligogenic Biomarkers in Ashkenazi Jews with Parkinson DiseaseNIHNational Institute of Neurological Disorders and Stroke2021 to 2023$4,228,325May 1, 2019March 31, 2025SAUNDERS-PULLMAN, RACHELreporter.nih.gov
Toxicant-induced neurotoxicity mediated by glia-neuron and gene-environment interactions in Parkinson's diseaseNIHNational Institute of Environmental Health Sciences2021 to 2025$4,217,249June 1, 2019April 30, 2027TIEU, KIMreporter.nih.gov
Peripheral Tissue Biomarker for Premortem Diagnosis of Lewy Body DementiaNIHNational Institute of Neurological Disorders and Stroke2022 to 2025$4,170,328December 15, 2021June 30, 2026CHEN, SHU G.reporter.nih.gov
Adaptive Neurostimulation to Restore Sleep in Parkinson's Disease: An Investigation of STN LFP Biomarkers in Sleep Dysregulation and RepairNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$4,098,597February 17, 2025June 30, 2026ABOSCH, AVIVAreporter.nih.gov
Neuro-exergaming for the Prevention and Remediation of Decline due to Parkinson's Disease: Clinical Trial of the Interactive Physical and Cognitive Exercise System (iPACES v3)NIHNational Institute of Neurological Disorders and Stroke2023 to 2025$4,081,293August 11, 2023July 31, 2027GILLEN, ROBERT WILLSONreporter.nih.gov
Discovery of Multimodal Biomarkers for Parkinsonian Syndromes, Their Progression, and Pathological RelevanceNIHNational Institute of Neurological Disorders and Stroke2021 to 2023$3,985,569June 1, 2019May 31, 2025MAILMAN, RICHARD Breporter.nih.gov
Skin biomarkers for diagnosing and characterizing AD and ADRDNIHNational Institute on Aging2021 to 2025$3,834,262September 30, 2021June 30, 2027KRAUS, ALLISON Lreporter.nih.gov
Synucleinopathies – Novel Targets in Early Diagnosis, Pathophysiology, and Therapeutic ApproachNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$3,826,830August 1, 2015June 30, 2027SINGER, WOLFGANGreporter.nih.gov
Elucidating the Biological Differences Between Distinct Fibrillar and Non-Fibrillar Alpha-Synuclein Inclusions in Human Stem-Cell ModelsNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$3,706,946July 1, 2020April 30, 2026KHURANA, VIKRAMreporter.nih.gov
Neurotoxic and neurodegenerative risks from chronic exposure to metal mixtures in e-cigarette aerosolNIHNational Institute of Environmental Health Sciences2021 to 2025$3,656,277September 8, 2021June 30, 2027RE, DIANE BERENGEREreporter.nih.gov
Basal Ganglia Cortical Coupling and Connectivity Changes in PD and DBSNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$3,646,454July 1, 1999January 31, 2029VITEK, JERROLD Lreporter.nih.gov
IND enabling CMC/safety/toxicology studies, submission of IND and pilot Phase 1 clinical trial with PV-1950R vaccine for Lewy Body Dementia (LBD)NIHNational Institute on Aging2024 to 2025$3,640,661June 5, 2024May 31, 2029AGADJANYAN, MICHAEL Greporter.nih.gov
Bilateral Closed Loop Deep Brain Stimulation for Freezing of Gait using Neural and Kinematic FeedbackNIHNational Institute of Neurological Disorders and Stroke2021 to 2023$3,624,489August 1, 2019July 31, 2025BRONTE-STEWART, HELENreporter.nih.gov
Determinants of Basal Ganglia Pathology in Parkinson's DiseaseNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$3,599,326April 15, 2021March 31, 2027SURMEIER, DALTON JAMESreporter.nih.gov
Dissect the mechanisms of selective regional vulnerability in Lewy Body Dementias via comparative snRNA-seq analysisNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$3,568,423July 15, 2021May 31, 2027ZHAO, GUOYANreporter.nih.gov
Region-Specific Vulnerability of the Lewy Body Dementia's BrainNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$3,557,900August 1, 2021June 30, 2027NA, CHAN-HYUNreporter.nih.gov
Advanced MRI studies of cerebrovascular and lymphatic abnormalities in LRRK2 mouse models of Parkinson's diseaseNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$3,536,285April 1, 2021March 31, 2027SMITH, WANLI Wreporter.nih.gov
Investigating neuroanatomical underpinnings of apathy in ADRD through neuroimaging and electrical manipulationNIHNational Institute of Mental Health2021 to 2025$3,513,225July 1, 2021June 30, 2027VANEGAS-ARROYAVE, NORAreporter.nih.gov
More than a Movement Disorder: Applying Palliative Care to Parkinson's Disease and Lewy Body DementiasNIHNational Institute of Nursing Research2021 to 2025$3,433,868September 15, 2016September 30, 2026KLUGER, BENZI Mreporter.nih.gov
Preclinical development of a novel therapeutic for Parkinson's diseaseNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$3,421,621September 30, 2021May 31, 2025BORDBAR, AARASHreporter.nih.gov
Modeling functional genomics of susceptibility to the persistent effects of environmental toxins in an elderly rural Indiana neurodegenerative cohortNIHNational Institute on Aging2022 to 2025$3,385,412September 15, 2022May 31, 2027BOWMAN, AARON Breporter.nih.gov
Deciphering innate immune signaling mechanisms in glial cells linking lifetime environmental exposures to neuroinflammation, protein aggregation and neurodegeneration in Parkinsons diseaseNIHNational Institute of Environmental Health Sciences2023 to 2025$3,351,160June 12, 2023March 31, 2031TJALKENS, RONALDreporter.nih.gov
The Role of Myeloid Cells in Parkinson's DiseaseNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$3,311,240April 1, 2021June 30, 2026RAJ, TOWFIQUEreporter.nih.gov
Preclinical trial for dysarthria treatment in Parkinson diseaseNIHNational Institute on Deafness and Other Communication Disorders2021 to 2025$3,266,069December 1, 2020November 30, 2025CIUCCI, MICHELLE RENEEreporter.nih.gov
A randomized, double blind, placebo-controlled study to evaluate the impact of Nilotinib treatment on safety, tolerability, pharmacokinetics and biomarkers in Dementia with Lewy Bodies (DLB)NIHNational Institute on Aging2021 to 2022$3,210,062July 1, 2019April 30, 2025MOUSSA, CHARBELreporter.nih.gov
Assessing Tele-Health Outcomes in Multiyear Extensions of Parkinson's Disease Trials-2 (AT-HOME PD-2)NIHNational Institute of Neurological Disorders and Stroke2023 to 2025$3,209,104May 1, 2023April 30, 2028SCHNEIDER, RUTHreporter.nih.gov
Directing Fate, Subtype Identity and Survival in Human Pluripotent-Derived Midbrain Dopamine NeuronsNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$3,203,281April 1, 2021March 31, 2027STUDER, LORENZ P.reporter.nih.gov
LRRK2 and inflammasome pathway in Parkinson's diseaseNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$3,192,206July 1, 2021June 30, 2027SMITH, WANLI Wreporter.nih.gov
Spatial organization and conformational ensembles of amyloids inside cellsNIHNational Institute of Neurological Disorders and Stroke2025$3,178,675August 13, 2025July 31, 2029FREDERICK, KENDRA KINGreporter.nih.gov
Deep Phenotypic Characterization of Prodromal Dementia with Lewy BodiesNIHNational Institute on Aging2022$3,171,435September 30, 2022August 31, 2025GALVIN, JAMES Ereporter.nih.gov
ENIGMA Parkinson’s Initiative: A Global Initiative for Parkinson’s DiseaseNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$3,159,326September 1, 2021August 31, 2026THOMPSON, PAUL Mreporter.nih.gov
Microbiome, Environment, and Parkinsons disease (MEP) PESTICIDE EXPOSURES AND THE GUT MICROBIOME IN PARKINSONS DISEASENIHNational Institute of Environmental Health Sciences2021 to 2025$3,143,396August 15, 2020June 30, 2026RITZ, BEATE R.reporter.nih.gov
Visual hallucinations and memory impairment in Parkinson's Disease: The role of hippocampal networksNIHNational Institute of Mental Health2021 to 2025$3,119,615September 1, 2021June 30, 2027BAKKER, ARNOLDreporter.nih.gov
Pesticides, Olfaction, and Neurodegeneration Among US FarmersNIHNational Institute of Environmental Health Sciences2021 to 2023$3,108,694February 1, 2019January 31, 2025CHEN, HONGLEIreporter.nih.gov
Neurophysiological Mechanisms Underlying Parkinsonian Motor SignsNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$3,106,163August 1, 2021June 30, 2027VITEK, JERROLD Lreporter.nih.gov
Preclinical Markers of ParkinsonismNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$3,073,020August 1, 2021June 30, 2027VAILLANCOURT, DAVID Ereporter.nih.gov
Production and Distribution of well-characterized polymorphic variants of alpha-synuclein aggregatesNIHNational Institute on Aging2022 to 2025$3,065,392September 30, 2022May 31, 2027SOTO, CLAUDIOreporter.nih.gov
Anxiety and depression in a nonhuman primate model of synucleinopathyNIHNational Institute of Neurological Disorders and Stroke2025$3,064,072August 4, 2025July 31, 2029EMBORG, MARINAreporter.nih.gov
Central cholinergic presbyvestibulopathy network changes and imbalance in Parkinson's disease and older personsNIHNational Institute on Aging2021 to 2025$3,043,334September 30, 2021May 31, 2027BOHNEN, NICOLAAS IDAreporter.nih.gov
Cutaneous Phosphorylated Alpha-Synuclein for Detection of Prodromal SynucleinopathiesNIHNational Institute of Neurological Disorders and Stroke2022 to 2024$3,000,000September 15, 2022August 31, 2025LEVINE, TODDreporter.nih.gov
Differential diagnosis of Parkinson's and multiple system atrophy in non-human primate models using a novel a-synuclein retinal contrast agent and AI-assisted analyticsNIHNational Institute of Neurological Disorders and Stroke2021 to 2022$2,977,682September 23, 2021August 31, 2024SARRAF, STELLAreporter.nih.gov
Single-Nuclei Multiomic Analysis of DLB ProgressionNIHNational Institute of Neurological Disorders and Stroke2022 to 2025$2,970,479August 17, 2022July 31, 2027KIM, YOON-SEONGreporter.nih.gov
Targeted Pathway Activation for PosturalInstability and Gait Disorder in Parkinson'sDiseaseNIHNational Institute of Neurological Disorders and Stroke2022 to 2025$2,952,277July 15, 2022June 30, 2027COOPER, SCOTT Ereporter.nih.gov
The effects of parkinsonism and deep brain stimulation on basal ganglia-thalamocortical circuitry during sleep-wake behaviorNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$2,950,204July 1, 2024March 31, 2029JOHNSON, LUKE AARONreporter.nih.gov
Systematic Study of Extracellular Vesicles and their Integrative Analysis with Parkinson's Organoids MAPNIHNational Institute of Neurological Disorders and Stroke2022 to 2025$2,931,350April 15, 2022March 31, 2027LEE, LUKE P.reporter.nih.gov
Development of a Blood-based Test for Identifying Synucleinopathy in Patients with DementiaNIHNational Institute of Neurological Disorders and Stroke2022 to 2025$2,919,989September 23, 2022August 31, 2026EITAN, EREZreporter.nih.gov
Brainstem-based imaging biomarkers of premanifest synucleinopathyNIHNational Institute on Aging2021 to 2024$2,913,904May 15, 2020April 30, 2026BIANCIARDI, MARTAreporter.nih.gov
Structural basis and physiological consequences of alpha-Synuclein binding to neurexin 1betaNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$2,894,995July 1, 2021June 30, 2027RHOADES, ELIZABETHreporter.nih.gov
Rehabilitation of Airway Protection in Parkinson's Disease: Comparing In-Person and Telehealth Service Delivery ModelsNIHNational Institute of Neurological Disorders and Stroke2022 to 2025$2,857,687September 1, 2022July 31, 2026TROCHE, MICHELLE Sreporter.nih.gov
Modeling and Mapping Human Action Regulation NetworksNIHNational Institute of Neurological Disorders and Stroke2023 to 2025$2,819,210August 15, 2023June 30, 2028POURATIAN, NADERreporter.nih.gov
An Integrated Biomarker Approach to Personalized, Adaptive Deep Brain Stimulation in Parkinson DiseaseNIHNational Institute of Neurological Disorders and Stroke2023 to 2025$2,778,905February 15, 2023January 31, 2027TURNER, DENNIS ALANreporter.nih.gov
Genetic Analysis of NeurodegenerationNIHNational Institute of Neurological Disorders and Stroke2023 to 2025$2,737,431May 1, 2023April 30, 2031FEANY, MEL Breporter.nih.gov
Simultaneous PET/phMR studies on interplay of mGlu/dopamine receptors in PD-like neurodegenerationNIHNational Institute of Neurological Disorders and Stroke2022 to 2025$2,725,861July 1, 2022June 30, 2027BROWNELL, ANNA-LIISAreporter.nih.gov
Vitamin K and D and Cognitive Impairment in Older AdultsNIHNational Institute on Aging2022 to 2025$2,723,572September 1, 2016March 31, 2027BOOTH, SARAH LOUISEreporter.nih.gov
Vesicular modulation of dopamine neuron toxicityNIHNational Institute of Environmental Health Sciences2021 to 2025$2,681,001November 17, 2014December 31, 2026MILLER, GARY Wreporter.nih.gov
A Computational Approach for Quantifying Motor Behaviors in Spinocerebellar Ataxias to Improve Early Detection of Motor Signs and Precisely Estimate Disease Severity and Disease ChangeNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$2,671,482April 15, 2021March 31, 2027GUPTA, ANOOPUM SATYAWANreporter.nih.gov
Identifying novel Parkinson'’s disease genes exploring understudied Latino populationsNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$2,667,664August 1, 2020July 31, 2025FERNANDEZ MATA, IGNACIOreporter.nih.gov
Mechanisms of LRRK2 Mediated NeurotoxicityNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$2,663,129September 1, 2010June 30, 2026WEST, ANDREW Breporter.nih.gov
Circuit-specific, chemogenetic neuromodulation in nonhuman primates.NIHNational Institute of Mental Health2023 to 2024$2,658,871June 15, 2023April 30, 2026SCHROEDER, CHARLES Ereporter.nih.gov
MULTIMODAL MRI TO PREDICT DBS MOTOR AND COGNITIVE OUTCOMES IN PARKINSON’S DISEASENIHNational Institute of Neurological Disorders and Stroke2022 to 2025$2,639,613September 19, 2022August 31, 2027MORRISON, MELANIE Areporter.nih.gov
Microbiome-gut-brain dysfunction in prodromal and symptomatic Lewy body diseasesNIHNational Institute of Neurological Disorders and Stroke2023 to 2025$2,637,479August 1, 2023July 31, 2028RYMAN, SEPHIRAreporter.nih.gov
The impact of early Tau pathology on cognitive progression and neuropsychiatric symptoms in Parkinson's diseaseNIHNational Institute of Neurological Disorders and Stroke2021 to 2023$2,609,788September 20, 2019August 31, 2025POSTON, KATHLEEN LOMBARDreporter.nih.gov
Racial Disparities in Parkinson Disease- Clinical Phenotype, Management and GeneticsNIHNational Institute of Neurological Disorders and Stroke2022 to 2025$2,609,599April 1, 2022March 31, 2027HALL, DEBORAH Areporter.nih.gov
Neuronal Activity in MC and SMA during STN and GPi DBS in the Parkinsonian MonkeyNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$2,604,080August 15, 2012July 31, 2025VITEK, JERROLD Lreporter.nih.gov
Biomarker discovery for parkinsonian diseases in extracellular vesicles from iPSC-derived neuronsNIHNational Institute of Neurological Disorders and Stroke2023 to 2024$2,555,369April 1, 2023March 31, 2026BITAN, GALreporter.nih.gov
Neurostimulation of the Nucleus Basalis of Meynert for the cognitive-motor syndrome in Parkinson's diseaseNIHNational Institute of Neurological Disorders and Stroke2024 to 2025$2,549,857August 19, 2022July 31, 2027BRONTE-STEWART, HELENreporter.nih.gov
Citalopram as a posterior cortical protective therapy in Parkinson diseaseNIHNational Institute on Aging2021 to 2024$2,545,093August 15, 2020April 30, 2026KOTAGAL, VIKASreporter.nih.gov
Acquisition of a FLUOstar Omega plate readerNIHNational Institute of General Medical Sciences2021 to 2024$2,541,466May 1, 2020April 30, 2026BAUM, JEAN Sreporter.nih.gov
Interrogating Maladaptive Serotonin Raphe-Striatal Plasticity in L-DOPA-Induced DyskinesiaNIHNational Institute of Neurological Disorders and Stroke2022 to 2025$2,540,892December 1, 2021November 30, 2026BISHOP, CHRISTOPHER Rreporter.nih.gov
Role of Glutamatergic Neurons in External Globus Pallidus in the Behavioral Deficits in Animal Models of Progressive Dopamine DepletionNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$2,533,610September 2, 2021June 30, 2027LIM, BYUNGKOOKreporter.nih.gov
Multi-tissue High-throughput Proteomic and Genomic Study in Parkinson's DiseaseNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$2,522,438September 30, 2020August 31, 2026BENITEZ, BRUNOreporter.nih.gov
Investigating physiologic and pathophysiologic connections between the Parkinson's disease protein alpha-synuclein and RNA binding proteinsNIHNational Institute of Neurological Disorders and Stroke2023 to 2025$2,493,768August 1, 2023July 31, 2028KHURANA, VIKRAMreporter.nih.gov
The role of a-synuclein accumulation in lysosomal hydrolase trafficking and functionNIHNational Institute of Neurological Disorders and Stroke2022 to 2025$2,474,168August 1, 2015April 30, 2027MAZZULLI, JOSEPH Rreporter.nih.gov
Characterizing the link between multiple environmental exposures and Parkinsons disease exacerbationNIHNational Institute of Environmental Health Sciences2022 to 2025$2,467,032September 20, 2022July 31, 2026ZANOBETTI, ANTONELLAreporter.nih.gov
Imaging epigenetic dysregulation in the Lewy body dementias with [11C]MartinostatNIHNational Institute on Aging2023 to 2025$2,463,125May 1, 2023March 31, 2028GOMPERTS, STEPHEN N.reporter.nih.gov
Optimizing coordinated reset deep brain stimulation for Parkinson's diseaseNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$2,462,398September 30, 2020June 30, 2026WANG, JINGreporter.nih.gov
Role of Subthalamic nucleus in Speech and Movement among people with Parkinson’s as Revealed by Intraoperative Recordings and Deep Brain StimulationNIHNational Institute on Deafness and Other Communication Disorders2021 to 2024$2,436,687July 1, 2020June 30, 2025GREENLEE, JEREMYreporter.nih.gov
Mechanisms of mitochondrial genome integrity in familial and idiopathic Parkinson's diseaseNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$2,430,578September 30, 2020August 31, 2025SANDERS, LAURIE Hreporter.nih.gov
Digital Markers of Mobility in Daily Life to Track Progression in Newly Diagnosed Parkinson's DiseaseNIHNational Institute on Aging2022 to 2025$2,430,381September 30, 2022May 31, 2027MANCINI, MARTINAreporter.nih.gov
Quantitative Imaging of Brain Glymphatic Function in HumansNIHNational Institute on Aging2021 to 2024$2,426,232April 15, 2020February 28, 2026DONAHUE, MANUS Jreporter.nih.gov
Comprehensive Augmented Reality Testing (CART) Platform for Parkinson’s diseaseNIHNational Institute of Neurological Disorders and Stroke2022 to 2025$2,416,358September 1, 2022July 31, 2027ALBERTS, JAY L.reporter.nih.gov
Spatiotemporal Optimization of Deep Brain Stimulation for Parkinson's DiseaseNIHNational Institute of Neurological Disorders and Stroke2022 to 2025$2,413,709July 15, 2016June 30, 2027JOHNSON, MATTHEW DOUGLASreporter.nih.gov
Neurofunctional Mechanisms of Changes in Cognition and Motor Function in Aging with HIV and Parkinson's DiseaseNIHNational Institute on Aging2023 to 2025$2,413,140May 15, 2023April 30, 2028SCHULTE, TILMANreporter.nih.gov
Innovating high-resolution novel imaging approaches to elucidate mechanisms of prion-like spreadingof neurodegenerative diseaseNIHNational Institute on Aging2021 to 2024$2,409,422May 1, 2020February 28, 2026LEE, JIN HYUNGreporter.nih.gov
TMEM106B in neurodegenerative diseaseNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$2,390,842July 15, 2013February 28, 2025CHEN-PLOTKIN, ALICE Sreporter.nih.gov
Development of a Microphysiological Organ-on-Chip System to Model AmyotrophicNIHNational Institute of Neurological Disorders and Stroke2021 to 2022$2,385,538September 15, 2017February 28, 2024SVENDSEN, CLIVE NIELSreporter.nih.gov
Dissecting the Etiology of The Lewy Body DementiasNIHNational Institute of Neurological Disorders and Stroke2022$2,383,188May 1, 2022April 30, 2025FINKBEINER, STEVEN Mreporter.nih.gov
Immunologic and Imaging studies with TNF Therapy in Prodromal SynucleinopathiesNIHNational Institute on Aging2025$2,361,361September 1, 2025August 31, 2030CEDARBAUM, JESSEreporter.nih.gov
Developmental underpinnings of substantia nigra vulnerabilityNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$2,358,716January 1, 2021December 31, 2026AWATRAMANI, RAJESHWAR Breporter.nih.gov
The Impact of Beta- and Gamma-synucleins on Alpha-synuclein's Synaptic FunctionNIHNational Institute of Neurological Disorders and Stroke2022 to 2023$2,342,275May 1, 2023March 31, 2024BURRE, JACQUELINEreporter.nih.gov
Neuroplasticity and the emergence of motor and cognitive deficits in prodromal synucleinopathyNIHNational Institute of Neurological Disorders and Stroke2022$2,336,166August 15, 2022July 31, 2025MACKINNON, COLUM Dreporter.nih.gov
Blinded Comparison of Different Alpha-Synuclein Seeding Assays as Cutaneous Biomarkers of Lewy Body DementiasNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$2,335,086September 15, 2021August 31, 2025BEACH, THOMAS Greporter.nih.gov
Investigations of Dementia in Parkinson DiseaseNIHNational Institute of Neurological Disorders and Stroke2023$2,332,494September 23, 2021August 31, 2026PERLMUTTER, JOEL SYNESreporter.nih.gov
Balance tele-rehabilitation with wearable technology for older adults with Parkinson diseaseNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2022 to 2025$2,320,587September 20, 2022June 30, 2027KING, LAURIEreporter.nih.gov
Protein Aggregation and Neurotransmitter Deficits in Parkinson DiseaseNIHNational Institute of Neurological Disorders and Stroke2022 to 2024$2,315,618August 1, 2016June 30, 2027KOTZBAUER, PAUL Treporter.nih.gov
LRRK2 Enzymatic Mechanisms of Neurodegeneration in Parkinson's DiseaseNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$2,313,250December 1, 2020November 30, 2025MOORE, DARREN JOHNreporter.nih.gov
Leveraging a Natural Experiment to Determine the Effects of Integrated Palliative Care on Health Service Outcomes and Disparities in Parkinson Disease and Lewy Body DementiaNIHNational Institute of Neurological Disorders and Stroke2023$2,307,536August 21, 2023July 31, 2026WILLIS, ALLISONreporter.nih.gov
Determine the role of atmospheric particulate matter pollutants in contributing to Lewy Body DementiaNIHNational Institute on Aging2023$2,296,059April 15, 2023March 31, 2026MAO, XIAOBOreporter.nih.gov
Resilience, Dysregulation, and Rescue of Basal Ganglia Indirect Pathway Function in Progressive ParkinsonismNIHNational Institute of Neurological Disorders and Stroke2022 to 2025$2,285,634April 1, 2001April 30, 2027BEVAN, MARK Dreporter.nih.gov
Novel fibril-selective nanobody-based agents targeting intracellular and extracellular α-synuclein aggregates and prion-like propagation induced dementiaNIHNational Institute of Neurological Disorders and Stroke2024$2,280,379September 19, 2024August 31, 2027WANG, WENJINGreporter.nih.gov
Discovery and characterization of selective D4R antagonists and their evaluation in preclinical models of PD-LIDsNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$2,271,548July 1, 2021June 30, 2027HOPKINS, COREY R.reporter.nih.gov
Propagation of Lewy pathology in Parkinson's and related disordersNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$2,263,224March 13, 2015November 30, 2026LUK, KELVIN Creporter.nih.gov
Heterochronic Blood Exchange Inhibits α?Synucleinopathy through Modulating Plasma Protein's Mediation on Pathological α?Synuclein SpreadingNIHNational Institute on Aging2021 to 2025$2,261,713September 30, 2021May 31, 2027MAO, XIAOBOreporter.nih.gov
Biomarkers and Risk Factors for Prodromal Parkinson's Disease and its ProgressionNIHNational Institute of Neurological Disorders and Stroke2022 to 2025$2,258,561April 1, 2022March 31, 2027ASCHERIO, ALBERTOreporter.nih.gov
Molecular and Network Analyses of Lewy Body Dementia PathogenesisNIHNational Institute on Aging2021$2,252,599September 5, 2021August 31, 2024CHIN, LIH-SHENreporter.nih.gov
A Large-scale Extracellular Vesicle RNA-seq Resource for Parkinsons DiseaseNIHNational Institute of Neurological Disorders and Stroke2023$2,250,030June 1, 2023May 31, 2025CRAIG, DAVID Wreporter.nih.gov
A Novel Instrument to Address Freezing of Gait in Parkinson's PatientsNIHNational Institute on Aging2024 to 2025$2,249,502September 15, 2021May 31, 2027CLARK, BRIAN Rreporter.nih.gov
Worldwide Tractometry Initiative to Investigate Brain Microstructure, Cognitive Impairment & Dementia in Parkinsons DiseaseNIHNational Institute of Neurological Disorders and Stroke2024$2,243,095June 1, 2024May 31, 2027THOMPSON, PAUL Mreporter.nih.gov
Vulnerability of the ascending arousal network to alpha-synuclein pathologyNIHNational Institute of Neurological Disorders and Stroke2024$2,234,905September 18, 2024August 31, 2027ALDRIDGE, GEORGINAreporter.nih.gov
Axonal Transport of mRNA for Mitochondrial ProteinsNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$2,224,546August 1, 2018April 30, 2025SCHWARZ, THOMAS L.reporter.nih.gov
Peripheral Biomarkers for Early Diagnosis of Mixed Pathologies in AD/ADRDNIHNational Institute on Aging2023 to 2025$2,219,859June 1, 2023February 29, 2028CHEN, SHU G.reporter.nih.gov
Role of DJ1 in mitochondrial biogenergetics and neuronal metabolismNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$2,212,107July 1, 2021June 30, 2026JONAS, ELIZABETH ANNreporter.nih.gov
Identification and Verification of S-Nitrosylated Proteins in Bodily Fluids as Biomarkers for Parkinson's Disease and Lewy Body DementiaNIHNational Institute of Neurological Disorders and Stroke2021$2,199,931July 1, 2021June 30, 2025NAKAMURA, TOMOHIROreporter.nih.gov
Neurostimulation of the Nucleus Basalis of Meynert for the cognitive-motor syndrome in Parkinson's diseaseNIHNational Institute of Neurological Disorders and Stroke2022 to 2023$2,192,915August 19, 2022July 31, 2024BRONTE-STEWART, HELENreporter.nih.gov
How Serine-129 Phosphorylation Status Affects the Spreading of α-Synuclein Pathology in Vivo: a Study in Knock-in AnimalsNIHNational Institute of Neurological Disorders and Stroke2023$2,192,716August 1, 2023July 31, 2026DETTMER, ULFreporter.nih.gov
Molecular Segregation of Parkinson’s Disease by Patient-Derived NeuronsNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$2,183,720June 1, 2020May 31, 2026FENG, JIANreporter.nih.gov
Mechanisms of gene regulation and RNA processing in synucleinopathiesNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$2,181,405July 1, 2020June 30, 2025MAZZULLI, JOSEPH Rreporter.nih.gov
Gene therapy targeting striatal dysfunction for Parkinson’s diseaseNIHNational Institute of Neurological Disorders and Stroke2022 to 2025$2,153,443February 1, 2022January 31, 2027PAPA, STELLA Mreporter.nih.gov
DBS Protocols for Long-Lasting Therapeutic Benefit in Mouse and Primate Models of Parkinson's DiseaseNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$2,148,826April 15, 2020February 28, 2026GITTIS, ARYN HILARYreporter.nih.gov
Biomarkers of cognitive decline in Parkinson's DiseaseNIHNational Institute of Neurological Disorders and Stroke2021 to 2023$2,148,559September 19, 2019June 30, 2024CHEN-PLOTKIN, ALICE Sreporter.nih.gov
Assessing skin biomarkers for preclinical diagnosis of PD and non-PD ParkinsonismNIHNational Institute of Neurological Disorders and Stroke2021 to 2023$2,147,422August 15, 2019May 31, 2025KONG, QINGZHONGreporter.nih.gov
α-Synuclein strain properties are associated with diagnosis of and progression to Parkinson's disease with dementiaNIHNational Institute of Neurological Disorders and Stroke2022$2,133,267March 1, 2022February 28, 2025MAO, XIAOBOreporter.nih.gov
Polo-like-kinase-2-dependent α-Synuclein Serine-129 Phosphorylation: a Physiological RoleDuring Synaptic ActivityNIHNational Institute of Neurological Disorders and Stroke2022$2,121,853July 15, 2022April 30, 2025DETTMER, ULFreporter.nih.gov
The Gut Brain Parkinson's Disease Consortium (GBPDC): Coordinating and Data Management Center (CDMC)NIHNational Institute of Diabetes and Digestive and Kidney Diseases2024 to 2025$2,119,283August 15, 2024June 30, 2029WRUCK, LISA Mreporter.nih.gov
Slow wave sleep as a biomarker of rehabilitation-induced cognitive improvement in Parkinson's diseaseNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2022 to 2025$2,113,374April 1, 2021March 31, 2027AMARA, AMY WILLISreporter.nih.gov
Molecular Mechanism of the Parkinson's Disease-associated protein LRRK2NIHNational Institute on Aging2022 to 2025$2,105,974August 1, 2022May 31, 2027HOANG, QUYEN QUOCreporter.nih.gov
Single-nucleus transcriptome profiling across multiple brain regions in Parkinson's DiseaseNIHNational Institute of Neurological Disorders and Stroke2021$2,099,553September 20, 2021August 31, 2023ROUSSOS, PANAGIOTISreporter.nih.gov
Comprehensive assessment of speech physiology and acoustics in Parkinson's disease progressionNIHNational Institute on Deafness and Other Communication Disorders2023 to 2025$2,093,716February 2, 2023January 31, 2028STEPP, CARA E.reporter.nih.gov
Mechanisms of Synaptic Dysfunction in Parkinson's and Other Synuclein-Linked DiseasesNIHNational Institute of Neurological Disorders and Stroke2022 to 2024$2,092,085June 1, 2022May 31, 2025MORGAN, JENNIFER REBECCAreporter.nih.gov
Differentiation and characterization of conformational alpha-synuclein strains associated with Parkinson's disease and related synucleinopathiesNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$2,090,020August 15, 2021May 31, 2027SHAHNAWAZ, MOHAMMADreporter.nih.gov
Superoxide-sensitive radiotracer as a predictive biomarker of Parkinson's disease progressionNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$2,077,197February 1, 2020December 31, 2025MCMANUS, MEAGAN JOYreporter.nih.gov
Decoding the BETA-arrestin2-LMBRD2 cascade in ALPHA-synuclein pathogenesis.NIHNational Institute of Neurological Disorders and Stroke2024$2,069,215August 6, 2024July 31, 2027WOO, JUNGA "ALEXA"reporter.nih.gov
Early Onset Parkinson’s disease subtypes and pathogenic mechanismsNIHNational Institute of Neurological Disorders and Stroke2023 to 2025$2,066,422September 1, 2023July 31, 2028RIBOLDI, GIULIETTA MARIAreporter.nih.gov
Peripheral Tissue Biomarker for Premorten Diagnosis of Lewy Body DementiaNIHNational Institute of Neurological Disorders and Stroke2021$2,065,446September 1, 2020June 30, 2025CHEN, SHU G.reporter.nih.gov
Human iPSC-Based Personalized Cell Therapy of PDNIHNational Institute of Neurological Disorders and Stroke2023 to 2025$2,062,628July 1, 2023April 30, 2028KIM, KWANG-SOOreporter.nih.gov
VTA dopamine neurons and cognitive symptoms of Parkinson’s diseaseNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$2,043,714April 1, 2021March 31, 2027NARAYANAN, NANDAKUMARreporter.nih.gov
Corticosubthalamic Plasticity in the Parkinsonian StateNIHNational Institute of Neurological Disorders and Stroke2021 to 2023$2,040,666September 18, 2019June 30, 2025SMITH, YOLANDreporter.nih.gov
Neuronal quality control and neuroprotection in tauopathiesNIHNational Institute on Aging2021 to 2024$2,040,301August 1, 2007April 30, 2026CHU, CHARLEEN Treporter.nih.gov
Mobility in Daily Life and Falls in Parkinson's Disease: Potential for RehabilitationNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2021 to 2024$2,033,210June 1, 2020May 31, 2026HORAK, FAY BAHLINGreporter.nih.gov
In vivo synaptic and dopamine transporter imaging in Parkinson's diseaseNIHNational Institute of Neurological Disorders and Stroke2022 to 2025$2,029,333August 1, 2022January 31, 2027MATUSKEY, DAVID Areporter.nih.gov
MicroRNAs in CNS-derived extracellular microvesicles as peripheral blood biomarkers for Alzheimer diseaseNIHNational Institute on Aging2021 to 2023$2,025,805March 1, 2019June 30, 2025SHI, MINreporter.nih.gov
Pathways, mechanisms, and treatments of vocal communication deficits in a Parkinson rat modelNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$2,018,747September 1, 2020June 30, 2030KELM-NELSON, CYNTHIA Areporter.nih.gov
Circuit-Inspired Strategies to Restore Basal Ganglia Function in Mouse Models of Parkinson’s DiseaseNIHNational Institute of Neurological Disorders and Stroke2023 to 2025$2,015,497May 1, 2023April 30, 2031GITTIS, ARYN HILARYreporter.nih.gov
Autophagon: an Autophagy-Functionalizing Gene Therapy Tool for Neurodegenerative DiseasesNIHNational Institute on Aging2023 to 2025$1,972,119March 15, 2022December 31, 2026YAKOUB, ABRAAM M.reporter.nih.gov
Neuroinflammatory Biomarkers for Nigrostriatal InjuryNIHNational Institute of Neurological Disorders and Stroke2021 to 2023$1,968,811June 1, 2019May 31, 2025PERLMUTTER, JOEL SYNESreporter.nih.gov
Human Dopamine Grafts in Alpha-Synuclein Models of Parkinson DiseaseNIHNational Institute of Neurological Disorders and Stroke2023 to 2025$1,967,447July 1, 2023June 30, 2028TABAR, VIVIANEreporter.nih.gov
Prospective memory impairment in Parkinson disease-related cognitive decline: Intervention and mechanismsNIHNational Institute on Aging2021 to 2024$1,964,673September 15, 2020May 31, 2026FOSTER, ERINreporter.nih.gov
Resolving the paradoxical effects of subthalamic deep-brain stimulation on inhibitory motor controlNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$1,959,489July 1, 2020August 31, 2030WESSEL, JAN Rreporter.nih.gov
Investigating the role of lipid metabolism in protein aggregation and neurodegenerative disease progressionNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$1,957,052December 1, 2020November 30, 2026DAVIS, MARIE YNEZreporter.nih.gov
Determining the circuits and signals of sleep dysfunction in Parkinson's disease through chronic intracranial recordings and closed-loop Deep Brain StimulationNIHNational Institute of Neurological Disorders and Stroke2023 to 2025$1,956,339April 1, 2023February 29, 2028LITTLE, SIMONreporter.nih.gov
The Pathophysiology of Network Synchrony in Parkinson's DiseaseNIHNational Institute of Neurological Disorders and Stroke2023 to 2025$1,956,329September 30, 2016July 31, 2028POURATIAN, NADERreporter.nih.gov
Optimizing Patient-Specific Deep Brain Stimulation Models Using ElectrophysiologyNIHNational Institute of Neurological Disorders and Stroke2022 to 2025$1,955,899January 1, 2022December 31, 2026MIOCINOVIC, SVJETLANAreporter.nih.gov
Mouse model studies of TMEM230-linked Parkinson's diseaseNIHNational Institute of Neurological Disorders and Stroke2022 to 2025$1,954,066September 30, 2016November 30, 2026DENG, HAN-XIANGreporter.nih.gov
Elucidating the role of NK cells in Lewy body diseasesNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$1,936,429February 1, 2021March 31, 2027LEE, JAE-KYUNG JAMISEreporter.nih.gov
Development of selective amyloid-responsive fluorescent probesNIHNational Institute on Aging2022$1,934,347June 1, 2022May 31, 2025YANG, JERRYreporter.nih.gov
The impact of synaptic vesicle-binding of alpha-synuclein on neuron function and neuropathologyNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$1,932,509June 1, 2020May 31, 2026BURRE, JACQUELINEreporter.nih.gov
Molecular Genetic Analysis of TORC1 and TORC2 Signaling in Neuronal MaintenanceNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$1,926,179December 15, 2013November 30, 2029LU, BINGWEIreporter.nih.gov
Striatal Mechanisms of Dyskinesia and Impulse Control in Parkinson’s DiseaseNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$1,915,009July 1, 2018April 30, 2028NELSON, ALEXANDRAreporter.nih.gov
Voltage Imaging Analysis of Striatal Network Dynamics Related to Movement, Parkinson's Disease and Deep Brain StimulationNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$1,912,300April 1, 2020March 31, 2026HAN, XUEreporter.nih.gov
Role of GlcSph in cognitive deficits in Lewy body dementiasNIHNational Institute on Aging2023 to 2025$1,911,743May 15, 2023March 31, 2028VOLPICELLI-DALEY, LAURA A.reporter.nih.gov
ProSAAS-mediated neuroprotective mechanisms in Alzheimer's and Parkinson's diseases: the role of secretory chaperones in neurodegenerationNIHNational Institute on Aging2021 to 2023$1,900,986February 1, 2019November 30, 2024LINDBERG, IRISreporter.nih.gov
Mechanisms and indicators of inflammasome signaling in Parkinson’s diseaseNIHNational Institute of Environmental Health Sciences2021 to 2023$1,896,582September 21, 2021August 31, 2025HAVRDA, MATTHEW CHARLESreporter.nih.gov
Exploiting New Fibril Structures to Understand the Biophysical Basis for Oligomerization and Toxicity of Alpha-SynucleinNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$1,895,793September 30, 2020August 31, 2025SACHS, JONATHAN Nreporter.nih.gov
The role of VAMP2 in alpha-synuclein function and pathologyNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$1,885,097April 15, 2021March 31, 2027DIAO, JIAJIEreporter.nih.gov
Towards Generating a Multimodal and Multivariate Classification Model from Imaging and Non-Imaging Measures for Accurate Diagnosis and Monitoring of Dementia in Parkinsons diseaseNIHNational Institute of Neurological Disorders and Stroke2022 to 2024$1,881,677September 1, 2020June 30, 2026MISHRA, VIRENDRA Rreporter.nih.gov
A theranostic system for ultrasound-facilitated blood-brain barrier openingNIHNational Institute of Biomedical Imaging and Bioengineering2021 to 2023$1,879,799March 1, 2020December 31, 2023KONOFAGOU, ELISA E.reporter.nih.gov
Linear predictive coding of EEG Activity for Diagnosis of Parkinson's Disease (LEAD-PD)NIHNational Institute of Neurological Disorders and Stroke2023$1,876,731June 1, 2023May 31, 2026UC, ERGUN Yreporter.nih.gov
Neuronal roles of Parkinsons Disease Vps13C in regulating autophagy and calcium dynamicsNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$1,856,046September 30, 2020January 31, 2026CARAVEOPISO, GABRIELAreporter.nih.gov
Understanding Cell-type Vulnerability and Oxidative Stress Pathology in Parkinson's Disease Using Isogenic Human Dopaminergic NeuronsNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$1,850,776September 1, 2020August 31, 2025BLANCHARD, JOEL WILLIAMreporter.nih.gov
Identifying Circuit Dynamics Underlying Motor Dysfunction in Parkinson’s Disease Using Real-Time Neural ControlNIHNational Institute of Neurological Disorders and Stroke2023 to 2025$1,831,432July 1, 2023June 30, 2028ESCOBAR SANABRIA, DAVIDreporter.nih.gov
Studying Aggregation in Neurodegenerative Disease using Synthetic ProteinsNIHNational Institute of Neurological Disorders and Stroke2023$1,825,919February 15, 2019July 31, 2026PETERSSON, ERNEST JAMESreporter.nih.gov
Chloride Homeostasis in Lysosomal Function and Parkinson's DiseaseNIHNational Institute of Neurological Disorders and Stroke2022 to 2025$1,813,734July 1, 2022April 30, 2028MAO, ZIXUreporter.nih.gov
Proteostasis dysregulation and alpha-synucleinNIHNational Institute of Neurological Disorders and Stroke2021 to 2023$1,813,410May 1, 2020April 30, 2025QI, XINreporter.nih.gov
Novel roles of VGLUT in sex differences in dopamine neuron vulnerability to environmental toxicant-induced neurodegenerationNIHNational Institute of Environmental Health Sciences2023 to 2025$1,811,672March 6, 2023December 31, 2027FREYBERG, ZACHARYreporter.nih.gov
Chemogenetic Inactivation of the Primate Internal Globus Pallidus as a Treatment for ParkinsonismNIHNational Institute of Neurological Disorders and Stroke2022 to 2025$1,806,350September 27, 2022August 31, 2027GALVAN, ADRIANAreporter.nih.gov
Sleep-specific DBS therapy in Parkinson's diseaseNIHNational Institute of Neurological Disorders and Stroke2023 to 2025$1,806,248April 1, 2023March 31, 2028JOHNSON, LUKE AARONreporter.nih.gov
Regulation of PINK1 and PARKIN-Dependent MitophagyNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$1,796,738September 25, 2013April 30, 2026HARPER, JEFFREY Wreporter.nih.gov
The contribution of the vermiform appendix to Parkinson's diseaseNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$1,785,152July 1, 2020June 30, 2025BRUNDIN, LENA CECILIAreporter.nih.gov
BIOMARKER DISCOVERY AND VALIDATION IN PSPNIHNational Institute of Neurological Disorders and Stroke2021 to 2022$1,775,155August 1, 2018April 30, 2025PANTELYAT, ALEXANDER Y.reporter.nih.gov
Precision-Mapping Functional Connectivity in Parkinson's DiseaseNIHNational Institute of Neurological Disorders and Stroke2023 to 2025$1,773,631February 1, 2023December 31, 2027CAMPBELL, MEGHAN Creporter.nih.gov
Epigenetic contributions to symptom asymmetry in Parkinson's diseaseNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$1,772,605April 1, 2020March 31, 2025COETZEE, GERHARD Areporter.nih.gov
Exploring mechanisms of Parkinson's disease-linked D620N VPS35 in rat modelsNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$1,772,605July 1, 2020June 30, 2025MOORE, DARREN JOHNreporter.nih.gov
Neuromechanical modeling of postural responses: Cortical mechanisms of balance impairments in Parkinson's diseaseNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2021 to 2025$1,771,273April 1, 2004August 31, 2029TING, LENA Hreporter.nih.gov
Neurovascular Effects of Dopamine Replacement Therapy in Parkinson's DiseaseNIHNational Institute of Neurological Disorders and Stroke2021 to 2023$1,769,883September 16, 2019May 31, 2025EIDELBERG, DAVIDreporter.nih.gov
Role of APOE in endosomal processing of alpha-synucleinNIHNational Institute on Aging2023 to 2024$1,757,895September 1, 2023August 31, 2025DAVIS, ALBERT Areporter.nih.gov
Parkinson Disease Neural Circuitry and Gastrointestinal PathobiologyNIHNational Institute of Diabetes and Digestive and Kidney Diseases2023 to 2025$1,756,788August 1, 2023May 31, 2027CAMILLERI, MICHAEL L.reporter.nih.gov
CYClical Lower Extremity exercise for Parkinsons trial (CYCLE Trial)NIHNational Institute of Neurological Disorders and Stroke2021 to 2023$1,752,215September 1, 2011April 30, 2026ALBERTS, JAY L.reporter.nih.gov
Cortical Network Modulation by Subthalamic Nucleus Deep Brain StimulationNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$1,739,970September 6, 2019June 30, 2025HERSHEY, TAMARA Greporter.nih.gov
Compensatory Mitochondrial Protective Mechanisms Against Oxidative Stress in PDNIHNational Institute of Neurological Disorders and Stroke2022 to 2025$1,730,971April 15, 2022March 31, 2027KANTHASAMY, ANUMANTHA GOUNDERreporter.nih.gov
Fluorescent IRE sensor for synucleinopathy drug discoveryNIHNational Institute of Neurological Disorders and Stroke2022 to 2023$1,728,231September 22, 2022August 31, 2025SHEN, WENreporter.nih.gov
Genetic and Molecular Basis of LongevityNIHNational Institute on Aging2022 to 2025$1,719,200April 1, 1999May 31, 2027RUVKUN, GARY Breporter.nih.gov
Synergistic Enhancement of ER proteostasis, trafficking, and lysosomes as treatments for Dementia with Lewy bodies and Parkinson’s disease-dementiaNIHNational Institute of Neurological Disorders and Stroke2024$1,707,089August 15, 2024July 31, 2027MAZZULLI, JOSEPH Rreporter.nih.gov
Combinatorial effects of PTMs on a-Synuclein structure, function and aggregationNIHNational Institute of Neurological Disorders and Stroke2022$1,706,062April 15, 2022March 31, 2025RHOADES, ELIZABETHreporter.nih.gov
Molecular Mechanisms of Oxidation Resistance 1 in Parkinson's disease and Lewy Body DementiaNIHNational Institute of Neurological Disorders and Stroke2023 to 2025$1,704,192August 1, 2023May 31, 2028THOMAS, BOBBYreporter.nih.gov
Role of N-terminal acetylation in alpha synuclein stability, function, and therapeutic targeting in synucleinopathiesNIHNational Institute of Neurological Disorders and Stroke2024 to 2025$1,693,159September 13, 2024July 31, 2029RHOADES, ELIZABETHreporter.nih.gov
Tissue Engineered Nigrostriatal Pathway for Anatomical Tract Reconstruction in Parkinson's DiseaseNIHNational Institute of Neurological Disorders and Stroke2023 to 2025$1,690,151September 1, 2023July 31, 2028CULLEN, DANIEL KACYreporter.nih.gov
Cortical Alpha-Synuclein in DementiaNIHNational Institute of Neurological Disorders and Stroke2023 to 2025$1,683,467February 15, 2023January 31, 2028ALDRIDGE, GEORGINAreporter.nih.gov
Cortical correlates of gait in Parkinson's disease: impact of medication and cueingNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2023 to 2025$1,677,923February 23, 2023January 31, 2028MANCINI, MARTINAreporter.nih.gov
Reciprocal interactions between cortical circuit dysfunction and α-synuclein pathologyNIHNational Institute of Neurological Disorders and Stroke2023 to 2025$1,674,295February 1, 2023January 31, 2028ZEIGER, WILLIAM ABELreporter.nih.gov
Advancing personalized medicine in PD using harmonized multi-site clinical dataNIHNational Institute of Neurological Disorders and Stroke2022 to 2024$1,666,423September 30, 2020August 31, 2025ERTEFAIE, ASHKANreporter.nih.gov
Cholinergic Mechanisms in Lewy Body DementiaNIHNational Institute of Neurological Disorders and Stroke2023 to 2025$1,653,870April 1, 2023March 31, 2028MOEHLE, MARK Sreporter.nih.gov
Alpha-Synuclein aberrantly modifies the nanoscale distribution and function of ion channels to promote neuronal cytotoxicityNIHNational Institute of Neurological Disorders and Stroke2023$1,650,534April 1, 2023March 31, 2028DICKSON, EAMONN JAMESreporter.nih.gov
A Dose Selection Trial of Light Therapy for Impaired Sleep in Parkinson's DiseaseNIHNational Institute of Neurological Disorders and Stroke2021$1,648,972September 15, 2019June 30, 2024VIDENOVIC, ALEKSANDARreporter.nih.gov
Parkinson Disease Clinical Subtypes: Validation, Clinical Utility, and Biological CorrelatesNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$1,648,353April 1, 2017April 30, 2028CAMPBELL, MEGHAN Creporter.nih.gov
Clinical performance testing of neuropacs in Parkinsonism diagnosisNIHNational Institute of Neurological Disorders and Stroke2024 to 2025$1,647,650June 15, 2023August 31, 2026BARMPOUTIS, ANGELOSreporter.nih.gov
Biophysical determination of the underlying cause of α-Syn oligomer toxicityNIHNational Institute of General Medical Sciences2021 to 2025$1,625,052August 15, 2021July 31, 2027KUROUSKI, DMITRYreporter.nih.gov
Mechanisms of Low-Dose Ketamine Treatment for Parkinson's DiseaseNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$1,624,779July 1, 2021June 30, 2025FALK, TORSTENreporter.nih.gov
The cross-talk between a-Synucleinopathies and T cell immunity in ADRDNIHNational Institute on Aging2024 to 2025$1,621,812August 15, 2024April 30, 2030MAO, XIAOBOreporter.nih.gov
MIF Nuclease actions in Synuclein DementiasNIHNational Institute on Aging2024 to 2025$1,620,473December 1, 2023November 30, 2028DAWSON, VALINA L.reporter.nih.gov
Analytical validation of a biochemical test for alpha-synuclein aggregates in biological fluids for the diagnosis of Parkinson's DiseaseNIHNational Institute of Neurological Disorders and Stroke2021 to 2022$1,619,186May 1, 2021April 30, 2023MACLEOD, KARENreporter.nih.gov
STRUCTURAL BIOLOGY OF ALPHA-SYNUCLEIN IN LEWY BODY DEMENTIANIHNational Institute of Neurological Disorders and Stroke2021 to 2022$1,611,362September 30, 2018August 31, 2023KOTZBAUER, PAUL Treporter.nih.gov
Dendrite regulation by the mitochondrial kinase PINK1: Implications for PD/LBDNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$1,596,950September 1, 2017June 30, 2029CHU, CHARLEEN Treporter.nih.gov
Genetic Silencing of Striatal CaV1.3 Calcium Channels as a Potent Antidyskinetic Therapy for PDNIHNational Institute of Neurological Disorders and Stroke2024 to 2025$1,596,160September 30, 2018May 31, 2029STEECE-COLLIER, KATHYreporter.nih.gov
Multi-scale functional connectivity in preclinical models of Parkinson's diseaseNIHNational Institute of Neurological Disorders and Stroke2022 to 2025$1,585,539January 1, 2022November 30, 2026STOKES, ASHLEY Mreporter.nih.gov
CSF Oligomeric α-synuclein targeted nano scavengers as a Parkinson's disease theranosticNIHNational Institute of Neurological Disorders and Stroke2024 to 2025$1,585,446September 18, 2024June 30, 2029TANIFUM, ERICreporter.nih.gov
Brain and Behavioral Indicators of Risk for Parkinsonism among Adolescents with Early Pesticide ExposureNIHNational Institute of Environmental Health Sciences2021 to 2022$1,583,679January 15, 2019December 31, 2024RAUH, VIRGINIA Areporter.nih.gov
Autoimmune features of neurodegenerative disordersNIHNational Institute of Neurological Disorders and Stroke2021 to 2022$1,580,796September 30, 2018July 31, 2024SULZER, DAVIDreporter.nih.gov
Investigations of Dementia in Parkinson DiseaseNIHNational Institute of Neurological Disorders and Stroke2021$1,574,996May 1, 2011August 31, 2023PERLMUTTER, JOEL SYNESreporter.nih.gov
Changes across the lifespan in the use of heuristics to guide decision-makingNIHNational Institute on Aging2022 to 2023$1,573,961May 1, 2019February 28, 2026BASSO, MICHELE Areporter.nih.gov
Role of arginylation in prevention of alpha synuclein-driven neurodegenerationNIHNational Institute of Neurological Disorders and Stroke2021 to 2023$1,573,670April 15, 2019March 31, 2025KASHINA, ANNA Sreporter.nih.gov
Effect of Agent and Host Factors on Alpha-Synuclein Strain PathogenesisNIHNational Institute of Neurological Disorders and Stroke2023 to 2025$1,572,020January 15, 2022July 31, 2027WOERMAN, AMANDA L.reporter.nih.gov
Metabolic Vulnerability of Synapses in Neurodegenerative DiseaseNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$1,571,619February 1, 2020January 31, 2026RYAN, TIMOTHY AIDANreporter.nih.gov
Microglial Hv1 Proton Channel as a Mediator of Environmentally-Induced Neuroinflammation and NeurodegenerationNIHNational Institute of Environmental Health Sciences2022 to 2023$1,566,923March 4, 2022July 31, 2023RICHARDSON, JASON Rreporter.nih.gov
Molecular Assessment of Cause and Consequence of Cellular Senescence in Diverse Midbrain Cell Types in Parkinson's DiseaseNIHNational Institute of Neurological Disorders and Stroke2022 to 2025$1,562,350July 15, 2022June 30, 2027RIESSLAND, MARKUSreporter.nih.gov
Genome-wide Prediction of Dementia in Parkinson DiseaseNIHNational Institute of Neurological Disorders and Stroke2021 to 2022$1,554,981September 20, 2019December 31, 2023SCHERZER, CLEMENS Rreporter.nih.gov
Mechanisms of pesticide-induced neuroinflammation and parkinsonism in aging mice.NIHNational Institute of Environmental Health Sciences2022 to 2025$1,553,785February 9, 2022May 14, 2025HAVRDA, MATTHEW CHARLESreporter.nih.gov
Daily Experiences and Well-being among Caregivers for Older Adults Experiencing Lewy Body Dementia.NIHNational Institute on Aging2024 to 2025$1,553,585May 1, 2024February 28, 2029FINGERMAN, KAREN Lreporter.nih.gov
Tele-Health Extension for Phase 3 Parkinson's Disease Trial CohortsNIHNational Institute of Neurological Disorders and Stroke2021 to 2022$1,552,312July 1, 2018April 30, 2024SCHWARZSCHILD, MICHAEL Areporter.nih.gov
The Role of KCa3.1 in Microglial function and in Parkinsons disease pathogenesisNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$1,547,582July 15, 2021April 30, 2027KANTHASAMY, ARTHIreporter.nih.gov
Investigating the Neurobiology of Early Cognitive ImpairmentNIHNational Institute of Neurological Disorders and Stroke2024 to 2025$1,547,395February 1, 2024January 31, 2029HUNTLEY, GEORGE W.reporter.nih.gov
Elucidating the Pathomechanisms of APOE4 in Lewy Body DementiaNIHNational Institute on Aging2024 to 2025$1,538,709July 1, 2024March 31, 2029ZHAO, NAreporter.nih.gov
Lewy Body Dementia BiomarkersNIHNational Institute of Neurological Disorders and Stroke2021 to 2022$1,536,368September 25, 2016November 30, 2023FREY, KIRK A.reporter.nih.gov
Direct CNS Delivery System for BDNF AntagoNATs using Heterotopic Mucosal Grafting for the Treatment of Parkinson's DiseaseNIHNational Institute of Neurological Disorders and Stroke2021 to 2023$1,535,794January 1, 2019August 31, 2024BLEIER, BENJAMINreporter.nih.gov
NOVEL PET MARKERS OF COGNITIVE IMPAIRMENT IN MANGANESE NEUROTOXICITYNIHNational Institute of Environmental Health Sciences2021 to 2022$1,525,888September 12, 2019May 31, 2024CRISWELL, SUSANreporter.nih.gov
Sing for Your Saunter: Using Self-Generated Rhythmic Cues to Enhance Gait in Parkinson'sNIHNational Center for Complementary & Integrative Health2023 to 2025$1,517,088September 15, 2019June 30, 2026EARHART, GAMMON M.reporter.nih.gov
Mechanisms of spreading proteinopathy in Lewy Body DementiaNIHNational Institute of Neurological Disorders and Stroke2021$1,512,234September 15, 2021August 31, 2024UNNI, VIVEKreporter.nih.gov
The Function of SynucleinNIHNational Institute of Neurological Disorders and Stroke2021 to 2023$1,510,563February 1, 2019January 31, 2024EDWARDS, ROBERT Hreporter.nih.gov
Glial Involvement in REDOX Homeostasis in the Substantia NigraNIHNational Institute of Neurological Disorders and Stroke2023 to 2025$1,509,712July 1, 2021April 30, 2027COWELL, RITA MARIEreporter.nih.gov
Mapping Synaptic Density in Prodromal and Manifest Lewy Body DementiaNIHNational Institute on Aging2024 to 2025$1,505,046September 25, 2024July 31, 2030GALLAGHER, CATHERINE L.reporter.nih.gov
Mitochondrial Sirtuin 3 in Parkinson's diseaseNIHNational Institute of Neurological Disorders and Stroke2021 to 2023$1,499,835June 1, 2019May 31, 2025MCLEAN, PAMELA Jreporter.nih.gov
Enhancing Physical Therapy with Brain Stimulation for Treating Postural InstabilityNIHNational Institute of Neurological Disorders and Stroke2021 to 2022$1,499,766September 1, 2021August 31, 2024WAGNER, TIMOTHY ANDREWreporter.nih.gov
Quantitative MR Imaging of Vascular Factors in Parkinsons DiseaseNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$1,494,509September 30, 2020June 30, 2026HERNANDEZ-GARCIA, LUISreporter.nih.gov
Genome-Wide Prediction of Dementia in Parkinson's DiseaseNIHNational Institute of Neurological Disorders and Stroke2022 to 2025$1,487,365September 20, 2019December 31, 2026SCHERZER, CLEMENS Rreporter.nih.gov
Understanding biomarkers of cognitive decline in Lewy body diseasesNIHNational Institute of Neurological Disorders and Stroke2024 to 2025$1,481,568September 19, 2019June 30, 2026CHEN-PLOTKIN, ALICE Sreporter.nih.gov
NINDS CENTER FOR CLINICAL RESEARCHNIHNational Institute on Drug Abuse2021 to 2022$1,478,090September 30, 2017September 29, 2022CLEMONS, TRACI Ereporter.nih.gov
Anti-inflammatory signals and neurodegenerationNIHNational Institute of Neurological Disorders and Stroke2024 to 2025$1,467,006September 1, 2024June 30, 2028CONTI, BRUNOreporter.nih.gov
SCH: Enabling Data Outsourcing and Sharing for AI-powered Parkinson's ResearchNIHNational Library of Medicine2021 to 2024$1,453,331September 3, 2021May 31, 2026CHEN, SHIGANGreporter.nih.gov
LEGENNDS: Linking Epidemiology and GEnetics of Neurodevelopmental and Neurodegenerative Disorders StudyNIHNational Institute of Neurological Disorders and Stroke2023 to 2024$1,448,091May 1, 2023April 30, 2028LEE, BRIAN KANEreporter.nih.gov
Molecular and Network Analyses of Lewy Body Dementia PathogenesisNIHNational Institute on Aging2024 to 2025$1,448,065September 5, 2021August 31, 2027CHIN, LIH-SHENreporter.nih.gov
A cross-sectional and longitudinal study of gut microbiota in Parkinson's diseaseNIHNational Institute of Diabetes and Digestive and Kidney Diseases2024 to 2025$1,444,898August 15, 2024June 30, 2029XIE, TAOreporter.nih.gov
The Bidirectional Gut-Microbiota-Brain Axis in Parkinson’s disease: integrating mechanistic biomarkers of disease severity and progressionNIHNational Institute of Diabetes and Digestive and Kidney Diseases2024 to 2025$1,441,314August 15, 2024June 30, 2029KESHAVARZIAN, ALIreporter.nih.gov
Effects of deep brain stimulation (DBS) on laryngeal function and associated behaviors in Parkinson DiseaseNIHNational Institute on Deafness and Other Communication Disorders2023 to 2025$1,439,077August 10, 2023July 31, 2028HEGLAND, KAREN Wreporter.nih.gov
Role of Rab27b in synucleinopathiesNIHNational Institute of Neurological Disorders and Stroke2021$1,433,631September 1, 2021August 31, 2024YACOUBIAN, TALENE ALENEreporter.nih.gov
A causal framework of communicative participation in people with Parkinson's disease.NIHNational Institute on Deafness and Other Communication Disorders2023 to 2025$1,432,497June 15, 2023May 31, 2028BORRIE, STEPHANIE ANNAreporter.nih.gov
S-Nitrosylation-Dependent Pathological Spread of Abnormal Proteins in Frontotemporal Dementia and Lewy Body DementiaNIHNational Institute of Neurological Disorders and Stroke2024 to 2025$1,431,052August 1, 2021July 31, 2027NAKAMURA, TOMOHIROreporter.nih.gov
Calcium homeostasis in organellesNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$1,430,661July 1, 2020May 31, 2025KRISHNAN, YAMUNAreporter.nih.gov
Dopaminergic and Muscarinic Signaling in the StriatumNIHNational Institute of Neurological Disorders and Stroke2024 to 2025$1,430,223July 1, 2024June 30, 2027SURMEIER, DALTON JAMESreporter.nih.gov
Motor cortical circuitry adaptations in experimental Parkinson's diseaseNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$1,430,012April 15, 2021March 31, 2024CHU, HONG-YUANreporter.nih.gov
14-3-3 phosphorylation in Parkinson's diseaseNIHNational Institute of Neurological Disorders and Stroke2021 to 2023$1,428,181September 15, 2019May 31, 2025YACOUBIAN, TALENE ALENEreporter.nih.gov
Mayo Clinic Consortium for Gut Brain Communication in Parkinson (Administrative Supplement)NIHNational Institute of Diabetes and Digestive and Kidney Diseases2024 to 2025$1,425,498September 1, 2024June 30, 2029BHARUCHA, ADIL E.reporter.nih.gov
Molecular Regulation of LRRK2 in Parkinson's DiseaseNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$1,424,238December 1, 2019November 30, 2025XIONG, YULANreporter.nih.gov
Simplified, Scalable 24-hour adaptive deep brain stimulation for Parkinson’s diseaseNIHNational Institute of Neurological Disorders and Stroke2025$1,419,954January 15, 2025December 31, 2025STARR, PHILIP ANDREWreporter.nih.gov
Mechanistic Dissection of Lipase (LIPE) Regulation of Fatty Acid Homeostasis as a Parkinson's Disease and Lewy Body Dementia Therapeutic StrategyNIHNational Institute of Neurological Disorders and Stroke2024 to 2025$1,408,421June 1, 2024May 31, 2029FANNING, SARANNAreporter.nih.gov
Consultative Physical Therapy: A Physical Activity and Exercise Implementation Strategy in Parkinson'sNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2023 to 2025$1,404,802June 13, 2023May 31, 2028RAFFERTY, MIRIAM ROSEreporter.nih.gov
NADPH Oxidase 2 in Parkinson's Disease PathogenesisNIHNational Institute of Neurological Disorders and Stroke2023 to 2025$1,403,816December 5, 2022November 30, 2027DI MAIO, ROBERTOreporter.nih.gov
Identification of mechanisms by which cytisine and estrogen inhibit ER stress and exert neuroprotection in Parkinson's diseaseNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$1,398,086February 15, 2020January 31, 2026SRINIVASAN, RAHULreporter.nih.gov
Interaction of Pyrethroid Exposure and the Microbiome on Parkinson's Disease related PathologiesNIHNational Institute of Environmental Health Sciences2022 to 2025$1,391,256February 9, 2022November 30, 2026SAMPSON, TIMOTHY ROBERTreporter.nih.gov
Towards a comprehensive understanding of the neurotoxic spread of α-synuclein from gut to brain in Parkinson's diseaseNIHNational Institute of Neurological Disorders and Stroke2024$1,386,000September 17, 2024August 31, 2027MOR, DANIELLE EMILLEreporter.nih.gov
Stimulus-evoked directional field potentials to guide subthalamic and pallidal DBS for PDNIHNational Institute of Neurological Disorders and Stroke2025$1,382,351December 18, 2023November 30, 2028WALKER, HARRISON CARROLLreporter.nih.gov
An Application of Advanced Imaging and Visualization to Clinical Deep Brain StimulationNIHNational Institute of Neurological Disorders and Stroke2022 to 2025$1,380,785January 1, 2021January 31, 2026MCINTYRE, CAMERONreporter.nih.gov
TMEM230 and Neurodegeneration in Parkinson's DiseaseNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$1,376,101September 30, 2020August 31, 2025XIA, XUGANGreporter.nih.gov
The Role of Aberrant Histone Acetylation in the Pathogenesis of Parkinson’s Disease and Related Synucleinopathies.NIHNational Institute of Neurological Disorders and Stroke2024 to 2025$1,366,666July 17, 2024June 30, 2028SOLDNER, FRANKreporter.nih.gov
Defining mechanisms of AAA+ disaggregasesNIHNational Institute of General Medical Sciences2021 to 2024$1,366,630January 1, 2013May 31, 2025SHORTER, JAMESreporter.nih.gov
Effects of 14-3-3θ phosphorylation vesicular transport and alpha-synuclein aggregationNIHNational Institute of Neurological Disorders and Stroke2025$1,361,977June 1, 2025May 31, 2027YACOUBIAN, TALENE ALENEreporter.nih.gov
Biophysical Characterization of Subthalamic Local Field Potentials in Parkinson's DiseaseNIHNational Institute of Neurological Disorders and Stroke2022 to 2024$1,360,496February 1, 2021January 31, 2025MCINTYRE, CAMERONreporter.nih.gov
Structural analysis of the human LRRK2NIHNational Institute of Neurological Disorders and Stroke2023 to 2025$1,351,350May 17, 2023April 30, 2028LEE, CHIA-HSUEHreporter.nih.gov
Noninvasive Biomarkers to Advance Emerging DBS Electrode Technologies in Parkinson's DiseaseNIHNational Institute of Neurological Disorders and Stroke2021$1,349,258September 30, 2016June 30, 2023WALKER, HARRISON CARROLLreporter.nih.gov
The Pallidohabenular System in ParkinsonismNIHNational Institute of Neurological Disorders and Stroke2024 to 2025$1,344,615January 4, 2024December 31, 2028SMITH, YOLANDreporter.nih.gov
Biologically Novel Mouse Models of PD with Progressive Synucleinopathy and Early-Onset Tremor and Motor Deficits Responsive to L-DOPANIHNational Institute of Neurological Disorders and Stroke2024$1,344,552May 15, 2019June 30, 2027NUBER, SILKEreporter.nih.gov
Role of altered gut immune response in Lewy Body DiseaseNIHNational Institute of Diabetes and Digestive and Kidney Diseases2024 to 2025$1,338,898September 1, 2024June 30, 2029POSTON, KATHLEEN LOMBARDreporter.nih.gov
Crosstalk Between Nurr1 and Risk Factors of Parkinson's Disease and its Regulation by Nurr1's LigandsNIHNational Institute of Neurological Disorders and Stroke2023 to 2025$1,331,032May 1, 2023April 30, 2027KIM, KWANG-SOOreporter.nih.gov
Striatal Trans-Synaptic Signaling Mechanism in ParkinsonismNIHNational Institute of Neurological Disorders and Stroke2024 to 2025$1,328,422September 1, 2024August 31, 2029DRAVID, SHASHANK MANOHARreporter.nih.gov
Glial Involvement in REDOX Homeostasis in the Substantia NigraNIHNational Institute of Neurological Disorders and Stroke2021 to 2022$1,326,101July 1, 2021November 30, 2022COWELL, RITA MARIEreporter.nih.gov
ATP13A2 and Susceptibility to NeurodegenerationNIHNational Institute of Environmental Health Sciences2021 to 2024$1,324,559September 28, 2020June 30, 2025FLEMING, SHEILAreporter.nih.gov
The Role of GPNMB in Parkinson's Disease.NIHNational Institute of Neurological Disorders and Stroke2024 to 2025$1,312,338August 1, 2024June 30, 2029SOLDNER, FRANKreporter.nih.gov
Phase I Cell Therapy for Maintaining Cholinergic Circuits in the Spectrum of Alzheimer’s DiseaseNIHNational Institute on Aging2024 to 2025$1,310,770June 15, 2024May 31, 2029GERHARDT, GREG A.reporter.nih.gov
Identifying Targets for Fall-prevention Rehabilitation in People with Parkinson’s DiseaseNIHNational Institute on Aging2024 to 2025$1,293,402September 1, 2024June 30, 2029PETERSON, DANIEL SORENreporter.nih.gov
Intrinsically disordered domains of α-synuclein: effect of fibril formation and fibril polymorphsNIHNational Institute of Neurological Disorders and Stroke2024 to 2025$1,287,494April 1, 2024March 31, 2029SIEMER, ANSGAR Breporter.nih.gov
Regulation of Motor Function in Parkinson's DiseaseNIHNational Institute of Neurological Disorders and Stroke2021 to 2022$1,286,670March 1, 2004May 31, 2025PAPA, STELLA Mreporter.nih.gov
Analysis of Cutaneous Phosphorylated alpha-Synuclein to Identify Patients at Risk of Progressing from Essential Tremor to Parkinson's DiseaseNIHNational Institute of Neurological Disorders and Stroke2025$1,276,662September 5, 2025August 31, 2028GIBBONS, CHRISTOPHER Hreporter.nih.gov
Synaptic Dysfunction and Energy Failure in Parkinson's DiseaseNIHNational Institute of Neurological Disorders and Stroke2023 to 2025$1,274,048June 15, 2022March 31, 2027ZHANG, HUIreporter.nih.gov
Systematic investigation of disease-associated, regulatory variation; illuminating their prediction, molecular consequences and mechanisms contributing to risk of Parkinson disease (PD)NIHNational Institute of Neurological Disorders and Stroke2024 to 2025$1,260,922July 22, 2024June 30, 2029MCCALLION, ANDREW Sreporter.nih.gov
Targeting the FBXW7/PGC1 Pathway as a Therapeutic Strategy for Parkinson's DiseaseNIHNational Institute of Neurological Disorders and Stroke2024 to 2025$1,256,193March 15, 2024February 28, 2029SIMON, DAVID K.reporter.nih.gov
Deciphering Neuronal Control of Behavioral Initiation and SuppressionNIHOffice of the Director, National Institutes of Health2023 to 2025$1,252,500September 22, 2023July 31, 2028FERENCZI, EMILY ANNEreporter.nih.gov
Dieldrin-induced differential gene methylation and parkinsonian toxicity (R01ES031237)NIHNational Institute of Environmental Health Sciences2023 to 2025$1,247,552November 10, 2022October 31, 2026BERNSTEIN, ALISONreporter.nih.gov
Striatal Neuroplasticity Mechanisms that Preserve Motor Behavior in a model of Parkinson’s DiseaseNIHNational Institute of Neurological Disorders and Stroke2021 to 2023$1,246,445April 1, 2013July 31, 2024SEAL, REBECCA Preporter.nih.gov
Retinal Determinants of Circadian Function and Sleep-Wake Cycles in Parkinson's DiseaseNIHNational Institute of Neurological Disorders and Stroke2023 to 2024$1,244,735September 1, 2023May 31, 2029VIDENOVIC, ALEKSANDARreporter.nih.gov
Role of pathogenic Parkinsonian mutations in the seeding and propagation of alpha-synuclein in the CNSNIHNational Institute of Neurological Disorders and Stroke2021 to 2023$1,239,324April 1, 2019March 31, 2024SMEYNE, RICHARD Jreporter.nih.gov
Mimicking synuclein toxicity in plant cells to identify novel neuroprotective leadsNIHNational Institute of Neurological Disorders and Stroke2021 to 2022$1,235,033September 1, 2018August 31, 2025HUANG, CHIFUreporter.nih.gov
Stimulus-evoked directional field potentials to guide subthalamic and pallidal DBS for PDNIHNational Institute of Neurological Disorders and Stroke2024$1,232,410December 18, 2023November 30, 2024WALKER, HARRISON CARROLLreporter.nih.gov
Microglial Hv1 Proton Channel as a Mediator of Environmentally-Induced Neuroinflammation and NeurodegenerationNIHNational Institute of Environmental Health Sciences2024 to 2025$1,232,074February 14, 2024December 31, 2026RICHARDSON, JASON Rreporter.nih.gov
Understanding the Mechanism of Pathological alpha-Synuclein TransmissionNIHNational Institute of Neurological Disorders and Stroke2021 to 2023$1,228,125September 17, 2019June 30, 2024MAO, XIAOBOreporter.nih.gov
Which mechanisms of pollutant-induced mitochondrial dysfunction cause dopaminergic neurodegeneration?NIHNational Institute of Environmental Health Sciences2023 to 2025$1,226,895January 1, 2023October 31, 2025MEYER, JOEL NEWMANreporter.nih.gov
Controlling Bacterial Amyloid Formation and the Influence of Curli Subunits on Pathogenic Alpha-synuclein AggregationNIHNational Institute of General Medical Sciences2021 to 2025$1,226,404April 1, 2016March 31, 2029CHAPMAN, MATTHEW RICHARDreporter.nih.gov
The role of Lamp1 and lipid transport in the regulation of vesicle identityNIHNational Institute on Aging2024 to 2025$1,216,748February 1, 2024January 31, 2029JENNY, ANDREASreporter.nih.gov
Dementia with Lewy Bodies ConsortiumNIHNational Institute of Neurological Disorders and Stroke2025$1,215,498September 1, 2025August 31, 2028LEVERENZ, JAMES BRUCEreporter.nih.gov
A Consortium for Gut-Brain Communication in Parkinson's DiseaseNIHNational Institute of Diabetes and Digestive and Kidney Diseases2024 to 2025$1,215,100September 1, 2024June 30, 2029KUO, BRADENreporter.nih.gov
2023 NINDS Landis Mentoring AwardNIHNational Institute of Neurological Disorders and Stroke2021 to 2023$1,212,183September 30, 2014March 31, 2024STARR, PHILIP ANDREWreporter.nih.gov
The Interplay between Genetics and Aerobic Exercise to Slow Parkinson's disease (GEARS) TrialNIHNational Institute of Neurological Disorders and Stroke2024 to 2025$1,210,130January 18, 2024December 31, 2028ALBERTS, JAY L.reporter.nih.gov
PHS 2019-02 Omnibus Solicitation of the NIH, CDC, and FDA for SmallBusiness Innovation Research Grant Applications (Parent SBIR [R43/R44] ClinicalTrial Not AllowedNIHNational Institute of Neurological Disorders and Stroke2021$1,198,087September 30, 2020August 31, 2023LEVINE, TODDreporter.nih.gov
Neurophysiological Biomarkers of Movement Facilitation in Parkinson’s DiseaseNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$1,184,732September 1, 2021August 31, 2026CROSS, KATHRYN AMYreporter.nih.gov
Identifying and targeting the neural basis of depression in Parkinson's diseaseNIHNational Institute of Neurological Disorders and Stroke2024 to 2025$1,184,648April 1, 2024March 31, 2029HOLMES, SOPHIEreporter.nih.gov
SCH: An Augmented Reality Neurorehabilitation System for Monitoring and Management of Motor Symptoms of Parkinson's DiseaseNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2022 to 2025$1,183,447August 1, 2022July 31, 2027FUCHS, HENRYreporter.nih.gov
Reducing falls with Varenicline in Hypocholinergic Parkinson diseaseNIHNational Institute of Neurological Disorders and Stroke2024$1,180,332September 19, 2024August 31, 2025KOTAGAL, VIKASreporter.nih.gov
Investigate neuroinflammation in the brain of PD using S1P1 radioligandsNIHNational Institute of Neurological Disorders and Stroke2024 to 2025$1,174,036February 20, 2024January 31, 2029TU, ZHUDEreporter.nih.gov
High-throughput neurovascular-unit-on-a-chip with OASIS for modeling Parkinson's diseaseNIHNational Institute of Neurological Disorders and Stroke2024 to 2025$1,171,566April 1, 2024March 31, 2029KIM, DEOK-HOreporter.nih.gov
Characterizing the pathophysiological role of the pallido-thalamocortical motor pathway in Parkinson's diseaseNIHNational Institute of Neurological Disorders and Stroke2024 to 2025$1,169,275January 1, 2024December 31, 2028AMAN, JOSHUA Ereporter.nih.gov
Urate-LRRK2 interactions in Parkinson's diseaseNIHNational Institute of Neurological Disorders and Stroke2021 to 2023$1,165,465August 1, 2019May 31, 2025SCHWARZSCHILD, MICHAEL Areporter.nih.gov
Frontal midline delta/theta rhythms and cognitive control in PDNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$1,156,742September 25, 2017December 31, 2029NARAYANAN, NANDAKUMARreporter.nih.gov
Studies of SLC41A1, a Mg2+-Transporting Protein Linked to Parkinson's DiseaseNIHNational Institute of Neurological Disorders and Stroke2023 to 2025$1,142,880August 1, 2023May 31, 2028ZUBCEVIC, LEJLAreporter.nih.gov
Biologically novel mouse models of PD with progressive synucleinopathy and early-onset tremor and motor deficits responsive to L-DOPANIHNational Institute of Neurological Disorders and Stroke2021 to 2023$1,141,509May 15, 2019March 31, 2024NUBER, SILKEreporter.nih.gov
Walking and mHealth to Increase Participation in Parkinson Disease (WHIP-PD)NIHEunice Kennedy Shriver National Institute of Child Health & Human Development2021 to 2022$1,138,081June 15, 2018April 30, 2024ELLIS, THERESAreporter.nih.gov
Functional Magnetic Resonance Imaging and Deep Learning to Improve Deep Brain Stimulation TherapyNIHNational Institute of Neurological Disorders and Stroke2023 to 2025$1,135,169September 19, 2023November 30, 2028AJALA, AFISreporter.nih.gov
DBS-Expert Pro: Automated Deep Brain Stimulation Programming Using Functional MappingNIHNational Institute of Neurological Disorders and Stroke2025$1,134,607August 21, 2025June 30, 2027HELDMAN, DUSTIN A.reporter.nih.gov
Prevention of complement and immune-mediated Lewy body dementiaNIHNational Institute on Aging2021 to 2022$1,133,146August 15, 2018April 30, 2023ISACSON, OLEreporter.nih.gov
Closed Loop Deep Brain Stimulation for Parkinson's DiseaseNIHNational Institute of Neurological Disorders and Stroke2021 to 2022$1,131,593July 1, 2022June 30, 2023STARR, PHILIP ANDREWreporter.nih.gov
Listener training for improved intelligibility of people with Parkinson's diseaseNIHNational Institute on Deafness and Other Communication Disorders2024 to 2025$1,128,236September 1, 2024May 31, 2029BORRIE, STEPHANIE ANNAreporter.nih.gov
Intersection of GBA and LRRK2 in Lewy Body DementiaNIHNational Institute on Aging2024 to 2025$1,127,274July 15, 2024April 30, 2029LAVOIE, MATTHEW Jreporter.nih.gov
Molecular mechanisms of alpha-synuclein induction and spread of pathobiologyNIHNational Institute of Neurological Disorders and Stroke2023$1,123,395March 1, 2023February 28, 2026GIASSON, BENOIT Ireporter.nih.gov
Mechanisms of Synaptic Dysfunction in Parkinson s and Other Synuclein-Linked DiseasesNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$1,117,086January 15, 2012May 31, 2027MORGAN, JENNIFER REBECCAreporter.nih.gov
Innovative systemic gene therapy for treating Parkinson's diseaseNIHNational Institute of Neurological Disorders and Stroke2021 to 2023$1,110,485May 15, 2019August 28, 2023SUK, JUNG SOOreporter.nih.gov
Development of S-PCT3010 to treat cognitive impairment in Alzheimers DiseaseNIHNational Institute of Neurological Disorders and Stroke2021$1,108,765March 1, 2021February 28, 2022SIELECKI, THAISreporter.nih.gov
Benefits of Exercise on Nigrostriatal Dopamine and Motor BehaviorNIHNational Institute of Neurological Disorders and Stroke2024 to 2025$1,107,146January 1, 2024December 31, 2028RICE, MARGARET Ereporter.nih.gov
Impaired sensory filtering as a mechanism of Parkinson's diseaseNIHNational Institute of Neurological Disorders and Stroke2022 to 2024$1,102,613August 1, 2022July 31, 2025IRWIN, ZACHARY THOMASreporter.nih.gov
Tau-dependent cognitive deficits in alpha-synucleinopathiesNIHNational Institute of Neurological Disorders and Stroke2021 to 2022$1,101,680May 15, 2018February 28, 2025LEE, MICHAEL Kreporter.nih.gov
Clinical trial readiness in X-linked dystonia parkinsonism: assessment of sensor-based and blood biomarkers for early detection and monitoring disease progressionNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$1,098,495September 1, 2021July 31, 2026STEPHEN, CHRISTOPHER Dreporter.nih.gov
Gut-brain axis in Parkinson's diseaseNIHNational Institute of Diabetes and Digestive and Kidney Diseases2022 to 2025$1,093,005July 1, 2020June 30, 2027SUBRAMANIAN, THYAGARAJANreporter.nih.gov
The role of lysosomal impairment in trichloroethylene induced Parkinsonian neurodegenerationNIHNational Institute of Environmental Health Sciences2024 to 2025$1,086,866February 25, 2024December 31, 2028DE MIRANDA, BRIANAreporter.nih.gov
Neurophysiology of movement transitions in Parkinson's disease with freezing of gaitNIHNational Institute of Neurological Disorders and Stroke2024 to 2025$1,059,572September 1, 2024May 31, 2029HUFFMASTER, SOMMER Lreporter.nih.gov
Quantitative Mapping of Substantia Nigra Iron in Parkinson's DiseaseNIHNational Institute of Neurological Disorders and Stroke2021 to 2022$1,053,052April 1, 2016January 31, 2024WANG, YIreporter.nih.gov
Continuous wearable monitor for the detection and release of Freezing of GaitNIHNational Institute on Aging2021$1,044,365September 15, 2017May 31, 2025CONDON, JOHN PAULreporter.nih.gov
CRCNS: US-France-Israel Research Proposal: A personalized approach to brain stimulationNIHNational Institute of Biomedical Imaging and Bioengineering2022 to 2024$1,042,872September 30, 2020June 30, 2026LEE, JIN HYUNGreporter.nih.gov
Genetic Silencing of Striatal CaV1.3 Calcium Channels as a Potent Antidyskinetic Therapy for PDNIHNational Institute of Neurological Disorders and Stroke2021 to 2022$1,036,735September 30, 2018May 31, 2024STEECE-COLLIER, KATHYreporter.nih.gov
LRRK2 in Parkinson's Disease NeurodegenerationNIHNational Institute of Neurological Disorders and Stroke2022 to 2024$1,034,567January 15, 2022December 31, 2027MARTIN, IANreporter.nih.gov
PROTEOMIC MAPPING OF PATHOLOGICAL INTERACTIONS ACROSS THE SYNUCLEINOPATHY BRAINNIHNational Institute of Neurological Disorders and Stroke2022 to 2024$1,027,000August 15, 2022November 30, 2025KILLINGER, BRYANreporter.nih.gov
Mechanisms of spreading proteinopathy in Lewy Body DementiaNIHNational Institute of Neurological Disorders and Stroke2024 to 2025$1,026,156September 15, 2021August 31, 2027UNNI, VIVEKreporter.nih.gov
Impact of Dysfunctional BDNF on Dopamine Terminal Remodeling in the Parkinsonian StriatumNIHNational Institute of Neurological Disorders and Stroke2021 to 2023$1,024,635January 1, 2019December 31, 2023STEECE-COLLIER, KATHYreporter.nih.gov
The role of the free energy landscape in Parkin's function and dysfunction in health and diseaseNIHNational Institute of General Medical Sciences2021 to 2023$1,022,433March 1, 2020February 28, 2025WAND, A. JOSHUAreporter.nih.gov
Impact of human disease-causing mutation on striatal synaptic and behavioral plasticityNIHNational Institute of Neurological Disorders and Stroke2021 to 2022$1,019,333May 15, 2019March 31, 2023HUNTLEY, GEORGE W.reporter.nih.gov
A novel gene therapy approach to reduce neurotoxicity in Parkinson's diseaseNIHNational Institute of Neurological Disorders and Stroke2025$1,009,212July 4, 2025June 30, 2027BRUNDIN, LENA CECILIAreporter.nih.gov
Voice and Speech Sensorimotor Control in Parkinsons DiseaseNIHNational Institute on Deafness and Other Communication Disorders2021 to 2022$1,006,715March 16, 2018February 29, 2024STEPP, CARA E.reporter.nih.gov
Dieldrin-induced differential gene methylation and parkinsonian toxicityNIHNational Institute of Environmental Health Sciences2021 to 2022$1,004,112January 21, 2021August 31, 2022BERNSTEIN, ALISONreporter.nih.gov
Microfluidic cell squeezing platform for the transdifferentiation of somatic cells for efficient generation of a cell replacement therapy for Parkinsons DiseaseNIHNational Institute of General Medical Sciences2022$1,001,356March 14, 2022December 15, 2022BRIDGEN, DEVINreporter.nih.gov
Regulation of lysosomal potassium channelsNIHNational Institute of General Medical Sciences2021 to 2025$1,001,049April 1, 2019March 31, 2029REN, DEJIANreporter.nih.gov
Simple, Home-use, neurostimulAtion tReatment for Parkinson's disease dEmeNtia (SHARPEN)NIHNational Institute of Neurological Disorders and Stroke2023 to 2024$994,322July 15, 2023April 2, 2025FOSTER, KRISTEN KATHLEENreporter.nih.gov
Alpha-Synuclein Assemblies and Metal-Mediated Redox MechanismsNIHNational Institute of General Medical Sciences2021 to 2023$989,164September 23, 2019July 31, 2025LUCAS, HEATHER Rreporter.nih.gov
Chaperone-mediated Autophagy and Synaptic Dysfunction in Parkinson's DiseaseNIHNational Institute of Neurological Disorders and Stroke2021 to 2022$986,946August 1, 2018May 31, 2023MAO, ZIXUreporter.nih.gov
LRRK2 and Oxidative Stress in Parkinson’s DiseaseNIHNational Institute of Neurological Disorders and Stroke2024 to 2025$981,320August 23, 2024July 31, 2028GREENAMYRE, J TIMOTHYreporter.nih.gov
Discovery of Chemical Factors in the Gut Microbiome that Control Alpha-Synuclein Aggregation in Parkinson's DiseaseNIHNational Institute of Neurological Disorders and Stroke2024 to 2025$973,617September 1, 2024August 31, 2029BESS, ELIZABETH NANCYreporter.nih.gov
Investigating Inhibitory Control Networks in Parkinson's DiseaseNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$964,696April 1, 2021March 31, 2026BENTLEY, JESSICA NICOLEreporter.nih.gov
Towards Generating a Multimodal and Multivariate Classification Model from Imaging and Non-Imaging Measures for Accurate Diagnosis and Monitoring of Dementia in Parkinsons disease.NIHNational Institute of Neurological Disorders and Stroke2021 to 2022$956,383September 1, 2020September 30, 2022MISHRA, VIRENDRA Rreporter.nih.gov
Selective autophagy in Parkinson'sdiseaseNIHNational Institute of Neurological Disorders and Stroke2021 to 2022$950,899July 1, 2018March 31, 2024YAMAMOTO, AIreporter.nih.gov
Role of the endolysosomal pathway in Lewy body dementia - from population genomics to single cellsNIHNational Institute on Aging2021$949,468July 1, 2021June 30, 2023BRAS, JOSEreporter.nih.gov
Substantia nigra circuits in instrumental actionNIHNational Institute of Neurological Disorders and Stroke2024 to 2025$942,223September 4, 2024August 31, 2029HOLLON, NICK GARBERreporter.nih.gov
Regulation of Dendrite Homeostasis by PINK1 and PKA in Models of Parkinson's DiseaseNIHNational Institute of Neurological Disorders and Stroke2021 to 2022$937,155April 1, 2018March 31, 2024DAGDA, RUBEN Kreporter.nih.gov
Structures and biological activity of alpha-synuclein aggregationNIHNational Institute on Aging2021 to 2023$933,114August 15, 2019April 30, 2024JIANG, LINreporter.nih.gov
Toward a speech rehabilitation model for linguistically and culturally minor groups: Foreign born immigrantsNIHNational Institute on Deafness and Other Communication Disorders2023 to 2025$932,094March 1, 2023February 28, 2027KIM, YUNJUNGreporter.nih.gov
Pesticide-Mediated Generation of a Toxic Neurotransmitter MetaboliteNIHNational Institute of Environmental Health Sciences2021 to 2022$927,227September 30, 2018August 31, 2024DOORN, JONATHAN Areporter.nih.gov
The Nigral Molecular Clock and Vulnerability to NeurodegenerationNIHNational Institute of Neurological Disorders and Stroke2021 to 2022$924,485July 15, 2018April 30, 2024GAMBLE, KAREN Lreporter.nih.gov
Oscillatory Neural Correlates of Motor Phenotypes in Parkinson DiseaseNIHNational Institute of Neurological Disorders and Stroke2023 to 2025$910,626September 1, 2022July 31, 2028INCE, NURI FIRATreporter.nih.gov
Gut-brain axis in Parkinson's diseaseNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021$908,901July 1, 2020June 30, 2022SUBRAMANIAN, THYAGARAJANreporter.nih.gov
a-Synuclein vulnerability mechanisms and therapeutics in Alzheimer's DiseaseNIHNational Institute on Aging2021$901,300September 1, 2001May 31, 2023RISSMAN, ROBERTreporter.nih.gov
Development of High-Speed and Quantitative Neuro MRI Technologies for Challenging Patient PopulationsNIHNational Institute of Neurological Disorders and Stroke2021 to 2022$857,446July 1, 2018March 31, 2025CHEN, NAN-KUEIreporter.nih.gov
RNA Targeted Drug Discovery and Development for Parkinson DiseaseNIHNational Institute of Neurological Disorders and Stroke2021$851,067June 1, 2021May 31, 2023MOURADIAN, M. MARALreporter.nih.gov
The Role of SYNJ1 in Dysregulating the Basal Ganglia FunctionNIHNational Institute of Neurological Disorders and Stroke2021 to 2022$845,248September 15, 2019May 31, 2023PAN, PING-YUEreporter.nih.gov
Slow wave sleep as a biomarker of rehabilitation-induced cognitive improvement in Parkinson's diseaseNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2021 to 2022$843,021April 1, 2021October 31, 2022AMARA, AMY WILLISreporter.nih.gov
Alpha-Synuclein Induced Network Hyperexcitability in Lewy Body DementiasNIHNational Institute on Aging2021$840,282September 30, 2021August 31, 2023VOSSEL, KEITH ALANreporter.nih.gov
Effect of agent and host factors on alpha-synuclein strain pathogenesisNIHNational Institute of Neurological Disorders and Stroke2022 to 2023$839,348January 15, 2022December 31, 2026WOERMAN, AMANDA L.reporter.nih.gov
Alpha-synuclein Regulates Dopamine Transporter FunctionsNIHNational Institute of Neurological Disorders and Stroke2021 to 2022$834,074September 15, 2010July 31, 2024KHOSHBOUEI, HABIBEHreporter.nih.gov
Pathological and cognitive correlations of real time quaking induced conversion in LBD and ADNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$828,489July 15, 2021June 30, 2027COUGHLIN, DAVID Greporter.nih.gov
Integrating pathogenic mechanisms in Parkinson's diseaseNIHNational Institute of Neurological Disorders and Stroke2021 to 2022$822,378June 15, 2018May 31, 2024SWANSON, RAYMOND Areporter.nih.gov
An in vivo multiplex model to study gene-environment interaction in Parkinson's DiseaseNIHNational Institute of Environmental Health Sciences2023 to 2025$809,767July 1, 2023June 30, 2026SARKAR, SOUVARISHreporter.nih.gov
Uncovering the neurophysiology of motivation in Parkinson™s disease with implanted adaptive brain stimulationNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$809,112March 1, 2021February 28, 2025LITTLE, SIMONreporter.nih.gov
DiSCERN: Advanced PD Therapy Candidacy and Evaluation SystemNIHNational Institute on Minority Health and Health Disparities2021$802,719September 20, 2018June 30, 2024HADLEY, AARON JOHNreporter.nih.gov
Molecular Mechanisms of Tubulin Polymerization Promoting Protein in Mitochondrial Function and Neuronal SurvivalNIHNational Institute of Neurological Disorders and Stroke2024 to 2025$795,678July 1, 2024June 30, 2029BANERJEE, SWATIreporter.nih.gov
Determining the mechanism of alpha-synuclein dependent innate immune responses in the brainNIHNational Institute of Neurological Disorders and Stroke2022 to 2023$794,078April 1, 2022June 30, 2023BECKHAM, JOHN DAVIDreporter.nih.gov
Changes in synaptic vesicle-binding of alpha-synuclein as an early biomarker for synucleinopathiesNIHNational Institute of Neurological Disorders and Stroke2025$793,535December 1, 2024November 30, 2029BURRE, JACQUELINEreporter.nih.gov
The Role of Alzheimer's Disease Genetic Risk in Predicting Parkinson's Disease DementiaNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$793,430September 15, 2020June 30, 2025TROPEA, THOMAS FRANCISreporter.nih.gov
Neuroplasticity and the emergence of motor and cognitive deficits in prodromal synucleinopathyNIHNational Institute of Neurological Disorders and Stroke2025$787,249August 15, 2022July 31, 2027MACKINNON, COLUM Dreporter.nih.gov
Contribution of transcriptional mutagenesis of oxidative DNA lesions to generatingnew mutant alpha-synuclein species and aggregation toward the pathogenesis of Parkinson'sdiseaseNIHNational Institute of Neurological Disorders and Stroke2021 to 2022$785,000May 15, 2018April 30, 2024KIM, YOON-SEONGreporter.nih.gov
The Impact of Beta- and Gamma-Synucleins on Alpha-Synuclein's Synaptic FunctionNIHNational Institute of Neurological Disorders and Stroke2025$783,258April 15, 2022March 31, 2027BURRE, JACQUELINEreporter.nih.gov
Neuron death in Parkinson's disease: The role of Trib3NIHNational Institute of Neurological Disorders and Stroke2021 to 2022$782,774June 1, 2012December 31, 2023GREENE, LLOYD Areporter.nih.gov
Imaging Epigenetic Mechanisms in the Lewy Body Dementias with [11C]MartinostatNIHNational Institute on Aging2021$776,355September 30, 2021August 31, 2023GOMPERTS, STEPHEN N.reporter.nih.gov
Cognitive and Affective Network Dysfunction and Neuromodulation in Aging and SynucleinopathyNIHNational Institute on Aging2021 to 2025$772,200May 1, 2021April 30, 2026BURNS, MATTHEW ROBERTreporter.nih.gov
Efficacy and Mechanisms of a Metacognitive Strategy Intervention for Parkinson disease-related Cognitive DeclineNIHNational Institute on Aging2025$771,627September 1, 2025August 31, 2030FOSTER, ERINreporter.nih.gov
Development and testing of Carbon Quantum Dot architectures to arrest neurotoxicant-insult- related outcomesNIHNational Institute of General Medical Sciences2022 to 2025$769,011August 1, 2022June 30, 2027NARAYAN, MAHESHreporter.nih.gov
Cortical-Subcortical Network Dynamics of Anesthesia and ConsciousnessNIHNational Institute of General Medical Sciences2021 to 2024$766,805April 1, 2020December 31, 2025POURATIAN, NADERreporter.nih.gov
Novel Re-engineered L DOPA Probiotic Therapy for Parkinson's DiseaseNIHNational Institute of Neurological Disorders and Stroke2022 to 2023$765,114September 1, 2021August 31, 2025KANTHASAMY, ANUMANTHA GOUNDERreporter.nih.gov
Dissecting the Etiology of The Lewy Body DementiasNIHNational Institute of Neurological Disorders and Stroke2025$764,836May 1, 2022April 30, 2027FINKBEINER, STEVEN Mreporter.nih.gov
Enhancing Cognitive Resilience In Parkinson's Disease: Role Of Antiaging Protein KlothoNIHNational Institute of Neurological Disorders and Stroke2022 to 2025$760,801September 1, 2022August 31, 2027LUTHRA, NIJEEreporter.nih.gov
Prion and non-prion induction mechanisms of alpha-synuclein pathologyNIHNational Institute of Neurological Disorders and Stroke2021 to 2022$759,146September 15, 2018June 30, 2025GIASSON, BENOIT Ireporter.nih.gov
The Role of a Neural Mechanism for Inhibitory Control in Cognitive FlexibilityNIHNational Institute of Neurological Disorders and Stroke2021 to 2022$756,864April 1, 2018March 31, 2024WESSEL, JAN Rreporter.nih.gov
The functional role of MAST1 in mediating a-synucleinopathies and related dementiaNIHNational Cancer Institute2021$749,756February 10, 2020December 31, 2021JIN, LINGTAOreporter.nih.gov
Mapping neurochemical activity of the basal ganglia in pathological behaviorsNIHNational Institute of Neurological Disorders and Stroke2021 to 2023$747,000August 1, 2018June 30, 2025SCHWERDT, HELEN Nreporter.nih.gov
ASC oligomerization and transmission as an initiating event for protein aggregation in Synucleinopathy DementiasNIHNational Institute on Aging2022 to 2024$746,997September 1, 2022August 31, 2025PANICKER, NIKHILreporter.nih.gov
Cerebellar TMS for postural instability in progressive supranuclear palsyNIHNational Institute of Neurological Disorders and Stroke2022 to 2025$745,023May 1, 2022April 30, 2027DALE, MARIAN LIVINGSTONreporter.nih.gov
Anxiety in Parkinson’s disease: using fMRI to evaluate amygdala networks in the on and off dopamine stateNIHNational Institute of Mental Health2025$742,576July 1, 2025April 30, 2026PONTONE, GREGORY MICHAELreporter.nih.gov
Role of presynaptic targeting of alpha-synuclein in the pathogenesis of Parkinson's Disease and Dementia with Lewy BodiesNIHNational Institute of Neurological Disorders and Stroke2021 to 2022$742,500May 1, 2018February 28, 2023VOLPICELLI-DALEY, LAURA A.reporter.nih.gov
Pathological striatopallidal neuronalensembles in learned motor impairment in PDNIHNational Institute of Neurological Disorders and Stroke2021 to 2022$741,562September 1, 2018May 31, 2024KANG, UN JUNGreporter.nih.gov
Higher Order Convolutional Neural Network for Classification of Lewy-body Diseases and Alzheimers DiseaseNIHNational Institute of Neurological Disorders and Stroke2024 to 2025$735,100February 15, 2022January 31, 2027VEMURI, BABA Creporter.nih.gov
Cerebellar cholinergic connections as a biomarker of dementia and gait impairment in Parkinson diseaseNIHNational Institute of Neurological Disorders and Stroke2022 to 2025$734,434March 1, 2022February 28, 2027MAITI, BAIJAYANTAreporter.nih.gov
Motor cortical circuitry adaptations in experimental Parkinson's diseaseNIHNational Institute of Neurological Disorders and Stroke2024 to 2025$729,300April 15, 2021January 31, 2027CHU, HONG-YUANreporter.nih.gov
Investigating Novel Genetic Variants that Confer Susceptibility to Pesticide-induced Parkinson's DiseaseNIHNational Institute of Environmental Health Sciences2025$728,408January 17, 2025November 30, 2029KAYE, JULIA ANNreporter.nih.gov
Elucidation of mitochondrial mechanisms critical to mediating PFAS neurotoxicityNIHNational Institute of Environmental Health Sciences2023 to 2025$727,893April 1, 2023March 31, 2026SAMMI, SHREESH RAJreporter.nih.gov
Studying Aggregation in Neurodegenerative Disease Using Synthetic ProteinsNIHNational Institute of Neurological Disorders and Stroke2021 to 2022$721,970February 15, 2019August 6, 2023PETERSSON, ERNEST JAMESreporter.nih.gov
Prediction of outcomes for deep brain stimulation using multimodal MRINIHNational Institute of Neurological Disorders and Stroke2023 to 2025$717,986December 1, 2021November 30, 2026YOUNCE, JOHN ROBERTreporter.nih.gov
Moving Mindfully: A MBSR-Centered Approach to Freezing in Parkinson DiseaseNIHNational Center for Complementary & Integrative Health2021 to 2023$717,792September 15, 2021June 30, 2024EARHART, GAMMON M.reporter.nih.gov
Single domain antibodies for diagnosis and treatment of synucleinopathiesNIHNational Institute on Aging2023$717,491September 30, 2023August 31, 2025SIGURDSSON, EINAR Mreporter.nih.gov
Immune System Aging in Parkinson’s and Alzheimer’s disease: Epigenetics, biologic aging, and heightened immune states in a population-based studyNIHNational Institute on Aging2021 to 2025$717,120May 1, 2021January 31, 2026PAUL, KIMBERLYreporter.nih.gov
The role of NOD2/RIPK2 signaling in the pathogenesis of Parkinson's DiseaseNIHNational Institute of Neurological Disorders and Stroke2021 to 2022$716,406July 15, 2018April 30, 2024KO, HANSEOKreporter.nih.gov
Investigating Subcortical Contributions to Speech Sequencing in Deep Brain Stimulator RecipientsNIHNational Institute on Deafness and Other Communication Disorders2025$715,574September 1, 2025August 30, 2030GUENTHER, FRANK Hreporter.nih.gov
Changes across the lifespan in the use of heuristics to guide decision-makingNIHNational Institute on Aging2021$711,784May 1, 2019October 15, 2021BASSO, MICHELE Areporter.nih.gov
Impact of nigral and extranigral neurodegeneration on aerodigestive discoordination in a pesticide model of Parkinson's diseaseNIHNational Institute of Environmental Health Sciences2024 to 2025$709,261September 1, 2024June 30, 2029GOULD, FRANCOISreporter.nih.gov
Cellular and Molecular Basis for Cognitive Impairment Associated with Glucocerebrosidase (GBA1) MutationNIHNational Institute of Neurological Disorders and Stroke2021 to 2022$708,750September 30, 2018January 31, 2025TANG, GUOMEIreporter.nih.gov
MC1R Basis of Melanoma-Parkinson's Link and Neuroprotective Potential of MC1RNIHNational Institute of Neurological Disorders and Stroke2021 to 2022$703,272April 1, 2018March 31, 2025CHEN, XIQUNreporter.nih.gov
PATHOLOGIC LRRK2 SIGNALING IN FAMILIAL AND IDIOPATHIC PARKINSON'S DISEASENIHNational Institute of Neurological Disorders and Stroke2021 to 2022$702,426September 30, 2018June 30, 2024LAVOIE, MATTHEW Jreporter.nih.gov
Higher Order Convolutional Neural Network for Classification of Lewy-body Diseases and Alzheimers DiseaseNIHNational Institute of Neurological Disorders and Stroke2022$702,265February 15, 2022January 31, 2024VEMURI, BABA Creporter.nih.gov
IND-enabling studies for cell therapy in Parkinson's diseaseNIHNational Institute of Neurological Disorders and Stroke2023 to 2024$700,000September 20, 2023February 28, 2026DAADI, MARCELreporter.nih.gov
In vivo Evaluation of USP30 Inhibitors in Models Relevant to Parkinson's DiseaseNIHNational Institute of Neurological Disorders and Stroke2023 to 2024$699,225September 19, 2023August 31, 2025BEHROUZ, BAHAREHreporter.nih.gov
The Neuroimmune Hypothesis of Paraquat: Connecting the Periphery and BrainNIHNational Institute of Environmental Health Sciences2021 to 2022$696,470February 1, 2018January 31, 2024BLOCK, MICHELLE Lreporter.nih.gov
Polo-like-kinase-2-dependent α-Synuclein Serine-129 Phosphorylation: a Physiological RoleDuring Synaptic ActivityNIHNational Institute of Neurological Disorders and Stroke2025$694,072July 15, 2022April 30, 2027DETTMER, ULFreporter.nih.gov
Pum2-dependent translational regulation of a-SYN near mitochondria and contribution to the pathogenesis of Parkinson's diseaseNIHNational Institute of Neurological Disorders and Stroke2021 to 2022$686,876September 15, 2018May 31, 2024KIM, YOON-SEONGreporter.nih.gov
Gene Therapy for Idiopathic Parkinson's DiseaseNIHNational Institute of Neurological Disorders and Stroke2024 to 2025$686,284September 1, 2024August 31, 2026BOLOTINA, VICTORIA Mreporter.nih.gov
A Thermoreversible 3D Manufacturing Platform for Scalable Production of Dopaminergic Neurons for Parkinson's Disease TherapyNIHNational Institute of Neurological Disorders and Stroke2021 to 2022$685,839August 1, 2021January 31, 2024MUCKOM, RIYAreporter.nih.gov
Progression Subtyping and Drug Target Identification for Parkinson's Disease with Integrative Machine LearningNIHNational Institute of Neurological Disorders and Stroke2025$684,451December 1, 2024November 30, 2029SU, CHANGreporter.nih.gov
Expanding Mentorship and Neuroimaging Expertise in Patient-Oriented Studies of Brain, Behavior, and Age-Related DementiasNIHNational Institute on Aging2021 to 2024$684,120September 10, 2020April 30, 2026CLAASSEN, DANIEL OLIVERreporter.nih.gov
Synthetic biology for controlled releaseNIHNational Institute of Biomedical Imaging and Bioengineering2021 to 2022$683,638May 4, 2019January 31, 2024ELLINGTON, ANDREW Dreporter.nih.gov
Theta burst subthalamic nucleus deep brain stimulation for cognitive and motor improvements in Parkinson's DiseaseNIHNational Institute of Neurological Disorders and Stroke2024$682,922September 18, 2024August 31, 2029LEE, DARRIN JASONreporter.nih.gov
Theta burst subthalamic nucleus deep brain stimulation for cognitive and motor improvements in Parkinson's DiseaseNIHNational Institute of Neurological Disorders and Stroke2025$678,336September 1, 2025August 31, 2029LEE, DARRIN JASONreporter.nih.gov
Cell-based Platform for Gene Delivery to the BrainNIHNational Institute of Neurological Disorders and Stroke2021 to 2022$677,159March 1, 2018November 30, 2023BATRAKOVA, ELENAreporter.nih.gov
Evaluating cell type-specific non-dopaminergics as a Parkinson's treatment paradigmNIHNational Institute of Neurological Disorders and Stroke2021 to 2022$676,957September 30, 2018June 30, 2024TADROSS, MICHAEL Rreporter.nih.gov
Autophagon: an Autophagy-Functionalizing Gene Therapy Tool for Neurodegenerative DiseasesNIHNational Institute on Aging2022 to 2023$676,932March 15, 2022July 31, 2023YAKOUB, ABRAAM M.reporter.nih.gov
α-Synuclein strain properties are associated with diagnosis of and progression to Parkinson's disease with dementiaNIHNational Institute of Neurological Disorders and Stroke2025$673,092March 1, 2022February 28, 2027MAO, XIAOBOreporter.nih.gov
The role of microglia in Parkinson's disease cognitive and motor impairmentNIHNational Institute of Neurological Disorders and Stroke2025$670,600January 1, 2025December 31, 2029MILLS, KELLY ALEXANDERreporter.nih.gov
LRRK in Autophagy Function and Dopaminergic Neuron SurvivalNIHNational Institute of Neurological Disorders and Stroke2021$670,490September 15, 2010October 31, 2023SHEN, JIEreporter.nih.gov
Neural Mechanisms underlying the benefits of Aerobic Exercise in Advanced Parkinson's diseaseNIHNational Institute on Aging2025$665,118September 15, 2025August 31, 2030ALBERTS, JAY L.reporter.nih.gov
Analytical Tools for Light-Initiated Zn2+ Signaling in Neurodegenerative DiseaseNIHNational Institute on Aging2025$661,537December 15, 2024November 30, 2029JOHNSON, MICHAEL A.reporter.nih.gov
Temporal Patterns of Deep Brain StimulationNIHNational Institute of Neurological Disorders and Stroke2021$660,715September 30, 2000August 31, 2024GRILL, WARREN M.reporter.nih.gov
Modulating Inhibitory Action Control Systems With Subthalamic Nucleus StimulationNIHNational Institute of Neurological Disorders and Stroke2021 to 2022$655,492January 15, 2018December 31, 2023VAN WOUWE, NELLEKE C.reporter.nih.gov
Characterization and targeting of a novel pathway promoting Parkinson’s DiseaseNIHNational Institute of Neurological Disorders and Stroke2023$647,116August 15, 2023July 31, 2025LAWRENCE, DANIEL Areporter.nih.gov
Anti-inflammatory signals and neurodegenerationNIHNational Institute of Neurological Disorders and Stroke2023$646,104September 21, 2023August 31, 2025CONTI, BRUNOreporter.nih.gov
Examining the role of phosphatidylethanolamine and autophagic disruption in Lewy Body Dementias and Parkinson's diseaseNIHNational Institute of Neurological Disorders and Stroke2021$642,408August 1, 2021January 31, 2024WITT, STEPHAN N.reporter.nih.gov
NeuroVision™: A Smartphone Application for Neurology and TelemedicineNIHNational Institute of Neurological Disorders and Stroke2022 to 2023$641,779July 15, 2022February 28, 2025SHIWANI, BHAWNAreporter.nih.gov
Exploiting Dopamine Receptor Functional Selectivity as an Approach to Treat Parkinson's SymptomsNIHNational Institute of Neurological Disorders and Stroke2021$636,146May 15, 2017June 30, 2022CARON, MARC G.reporter.nih.gov
HBI-002 to Treat Parkinson’s DiseaseNIHNational Institute of Neurological Disorders and Stroke2021 to 2022$633,912September 20, 2021August 31, 2024GOMPERTS, EDWARDreporter.nih.gov
Advancing personalized medicine in PD using harmonized multi-site clinical dataNIHNational Institute of Neurological Disorders and Stroke2021$631,099September 30, 2020August 31, 2022ERTEFAIE, ASHKANreporter.nih.gov
Glymphatic MR Imaging and Biomarker Discovery in Aging with HIV InfectionNIHNational Institute on Aging2025$629,712September 15, 2025August 31, 2027MULLER-OEHRING, EVA Mreporter.nih.gov
Protein Palmitoylation in Synuclein PathophysiologyNIHNational Institute of Neurological Disorders and Stroke2021 to 2023$626,910July 1, 2019June 30, 2024HO, GARY P. H.reporter.nih.gov
Dysregulation of Histone Acetylation in Parkinson's DiseaseNIHNational Institute of Neurological Disorders and Stroke2023$624,231July 11, 2023June 30, 2025SOLDNER, FRANKreporter.nih.gov
Brain Health Equity Research CollaborativeNIHNational Institute of Neurological Disorders and Stroke2025$617,687December 15, 2024November 30, 2029SHARRIEF, ANJAIL Zreporter.nih.gov
Influence of neuromelanin on single dopaminergic neurons in Parkinson's disease.NIHNational Institute of Neurological Disorders and Stroke2025$616,200February 1, 2025December 31, 2029BECKSTEAD, MICHAEL Jreporter.nih.gov
Neuroimaging of PDE10ANIHNational Institute of Neurological Disorders and Stroke2021$615,283September 15, 2017August 31, 2024PERLMUTTER, JOEL SYNESreporter.nih.gov
Investigating environmental and gene-environment contributors to Parkinson's disease risk by coupling quantitative environmental exposure data to iPSC modelingNIHNational Institute of Environmental Health Sciences2023 to 2025$615,207December 1, 2022November 30, 2027KROLEWSKI, RICHARD CARLreporter.nih.gov
Precision mapping of Parkinson's Disease pathophysiology in the Somato-Cognitive Action Network’s DBS targetsNIHNational Institute of Neurological Disorders and Stroke2025$613,897January 1, 2025December 31, 2029GORDON, EVAN M.reporter.nih.gov
Determining the mechanism of alpha-synuclein dependent innate immune responses in the brainNIHNational Institute of Neurological Disorders and Stroke2024 to 2025$607,778September 2, 2023March 31, 2027BECKHAM, JOHN DAVIDreporter.nih.gov
Rescuing ⍺-synuclein toxicity through neuron-specific enhancement of autophagyNIHNational Institute of Neurological Disorders and Stroke2023 to 2025$605,880May 15, 2023April 30, 2028CHUA, JASON PAULreporter.nih.gov
Build-up of beta-amyloid in the brain in Parkinson's diseaseNIHNational Institute of General Medical Sciences2022 to 2025$605,764July 1, 2022December 31, 2026INYUSHIN, MIKHAILreporter.nih.gov
SCH: AI-empowered wearable multimodal sensors (AI-MEDALLION) for noninvasive monitoringNIHNational Library of Medicine2024 to 2025$603,985September 18, 2024August 31, 2028ZHANG, CHIreporter.nih.gov
Investigation of non-invasive brain stimulation for the treatment of apathyNIHNational Institute of Mental Health2023 to 2025$603,648July 17, 2023June 30, 2027SKLEROV, MIRIAMreporter.nih.gov
Encephalitic viral infection and susceptibility to dopaminergic neurotoxinsNIHNational Institute of Environmental Health Sciences2021$603,534September 20, 2019August 31, 2024TJALKENS, RONALDreporter.nih.gov
Molecular Mechanisms of Diabetic Retinal Ganglion Cell Dysfunction and Neurovascular Crosstalk in Early Diabetic RetinopathyNIHNational Eye Institute2021 to 2023$598,239March 1, 2019February 28, 2025SACHDEVA, MIRA MENONreporter.nih.gov
Feasibility of Objective Measures and Outpatient Washout in Disease-Modifying Trials for Parkinson's DiseaseNIHNational Institute on Aging2021 to 2025$595,536June 1, 2021May 31, 2027HACKER, MALLORY L.reporter.nih.gov
Perception and Production of Speech Timing in Parkinson's DiseaseNIHNational Institute on Deafness and Other Communication Disorders2025$590,026September 18, 2025August 31, 2028FRANKFORD, SAULreporter.nih.gov
In vitro pharmacology and In vivo neuroprotective effects of CMPI analogues in an optimized Zebrafish model of Parkinsons diseaseNIHNational Institute of Neurological Disorders and Stroke2022 to 2025$588,000May 20, 2022April 30, 2026HAMOUDA, AYMAN K.reporter.nih.gov
Genome Wide Analysis of Alpha-Synuclein NeurotoxicityNIHNational Institute of Neurological Disorders and Stroke2021$585,729September 25, 2017June 30, 2024FEANY, MEL Breporter.nih.gov
Arousal and Timekeeping in a Mouse Model of Parkisonism (Supplement)NIHNational Institute of Neurological Disorders and Stroke2022 to 2024$583,993April 1, 2022March 31, 2026BUHUSI, CATALIN V.reporter.nih.gov
Leveraging invasive recordings and immersive virtual reality to characterize freezing of gait mechanisms in Parkinson diseaseNIHNational Institute of Neurological Disorders and Stroke2025$578,329April 1, 2025March 31, 2030CROSS, KATHRYN AMYreporter.nih.gov
Novel Systemic Delivery of Peptide-Mediated Anti-Sense Oligonucleotides for Dementia with Lewy BodiesNIHNational Institute on Aging2024$578,101May 15, 2021June 1, 2024RISSMAN, ROBERTreporter.nih.gov
Development of selective amyloid-responsive fluorescent probesNIHNational Institute on Aging2025$572,646June 1, 2022May 31, 2027YANG, JERRYreporter.nih.gov
Advancing Palliative Care for Older Adults Affected by Neurodegenerative Disease: Parkinsons disease, Alzheimers disease and Related DementiasNIHNational Institute on Aging2021 to 2024$568,772September 15, 2020May 31, 2025KLUGER, BENZI Mreporter.nih.gov
Speech markers of cognitive impairment in Parkinson's diseaseNIHNational Institute on Deafness and Other Communication Disorders2021 to 2023$567,618March 4, 2019February 28, 2025SMITH, KARA MICHELLEreporter.nih.gov
Parkinson's disease susceptibility in carriers of lysosomal storage disorder genesNIHNational Institute of Neurological Disorders and Stroke2021 to 2023$558,615September 19, 2019August 31, 2024ROBAK, LAURIE Areporter.nih.gov
LRRK2 and oxidative stress in Parkinson’s diseaseNIHNational Institute of Neurological Disorders and Stroke2023$556,500June 1, 2023May 31, 2024GREENAMYRE, J TIMOTHYreporter.nih.gov
A multiplexable in vivo perturbation toolkit to identify genes affecting neurodegeneration in a model of synucleinopathyNIHNational Institute on Aging2023 to 2024$554,302September 30, 2023September 29, 2025PRZEDBORSKI, SERGE Ereporter.nih.gov
Screening for Compounds that Lower Intracellular Alpha-Synuclein LevelsNIHNational Institute on Aging2021 to 2022$553,315May 15, 2021April 30, 2024JOHN, VARGHESEreporter.nih.gov
Bright light modulation of non-motor symptoms in Parkinson's diseaseNIHNational Institute of Neurological Disorders and Stroke2021$550,736December 1, 2016November 30, 2023VIDENOVIC, ALEKSANDARreporter.nih.gov
Linking Synucleinopathy and Dysfunction of Olfactory PathwaysNIHNational Institute on Deafness and Other Communication Disorders2021$544,426July 1, 2017June 30, 2022MOORE, DARREN JOHNreporter.nih.gov
Multi-site DBS with precise timing control focusing on synaptic plasticityNIHNational Institute on Alcohol Abuse and Alcoholism2025$539,237September 15, 2025June 30, 2030LUJAN, LUISreporter.nih.gov
Oscillatory Neural Correlates of Motor Phenotypes in Parkinson DiseaseNIHNational Institute of Neurological Disorders and Stroke2022 to 2023$536,427September 1, 2022August 14, 2023INCE, NURI FIRATreporter.nih.gov
Lysosomal dysregulation contributes to HANDNIHNational Institute on Aging2023$534,644September 1, 2023August 31, 2025SANTERRE, MARYLINEreporter.nih.gov
Neuron- and Circuit-Specific Mechanisms and Adaptations Regulating Motor Function in Parkinson Disease ModelsNIHNational Institute of Neurological Disorders and Stroke2021 to 2022$532,141July 1, 2009July 31, 2022KREITZER, ANATOLreporter.nih.gov

Organizations

OrganizationPlaceNIH awardsNIH amountNSF awardsNSF amount
Northwestern University at ChicagoChicago, IL22$41 million0$0
Johns Hopkins UniversityBaltimore, MD32$36.6 million0$0
Washington UniversitySaint Louis, MO26$35.6 million0$0
University of MinnesotaMinneapolis, MN19$31 million0$0
Brigham and Women's HospitalBoston, MA23$29.1 million0$0
University of PennsylvaniaPhiladelphia, PA26$28.5 million0$0
Emory UniversityAtlanta, GA23$27.8 million0$0
University of Alabama at BirminghamBirmingham, AL27$27.6 million0$0
University of FloridaGainesville, FL29$24.7 million0$0
Massachusetts General HospitalBoston, MA18$24 million0$0
Cleveland Clinic Lerner Com-CwruCleveland, OH10$19.3 million0$0
Stanford UniversityStanford, CA11$19 million0$0
Duke UniversityDurham, NC14$17 million0$0
University of IowaIowa City, IA13$16.2 million0$0
University of California Los AngelesLos Angeles, CA19$16.1 million0$0
University of California, San FranciscoSan Francisco, CA19$15.5 million0$0
Icahn School of Medicine at Mount SinaiNew York, NY14$14.9 million0$0
Oregon Health & Science UniversityPortland, OR14$14.6 million0$0
Columbia University Health SciencesNew York, NY11$14.5 million0$0
University of Michigan at Ann ArborAnn Arbor, MI10$14.4 million0$0
California Pacific Med CTR Res InstituteSan Francisco, CA1$13.3 million0$0
Van Andel Research InstituteGrand Rapids, MI13$13.2 million0$0
Mclean HospitalBelmont, MA6$13 million0$0
Case Western Reserve UniversityCleveland, OH7$12.8 million0$0
University of RochesterRochester, NY12$12.1 million0$0
Yale UniversityNew Haven, CT15$11.8 million0$0
University of Pittsburgh at PittsburghPittsburgh, PA14$11.4 million0$0
University of Wisconsin-MadisonMadison, WI10$10.8 million0$0
New York University School of MedicineNew York, NY9$10.7 million0$0
Ut Southwestern Medical CenterDallas, TX7$9.8 million0$0
Weill Medical Coll of Cornell UnivNew York, NY9$9.7 million0$0
Michigan State UniversityEast Lansing, MI12$9.1 million0$0
University of Southern CaliforniaLos Angeles, CA8$8.9 million0$0
University of California, San DiegoLa Jolla, CA9$8.6 million0$0
University of Georgia Research Foundation IncAthens, GA6$8.5 million0$0
Mayo Clinic RochesterRochester, MN5$8.5 million0$0
Florida International UniversityMiami, FL3$7.2 million0$0
Trustees of Boston UniversityBoston, MA8$7 million0$0
University of Nebraska Medical CenterOmaha, NE2$6.4 million0$0
Rush University Medical CenterChicago, IL6$6.1 million0$0
Pennsylvania State Univ Hershey Med CTRHershey, PA6$5.9 million0$0
Baylor College of MedicineHouston, TX5$5.9 million0$0
University of Texas HLTH Sci CTR HoustonHouston, TX3$5.8 million0$0
Colorado State UniversityFort Collins, CO3$5.5 million0$0
CND Life Sciences, Inc.Scottsdale, AZ3$5.5 million0$0
Beth Israel Deaconess Medical CenterBoston, MA6$5.2 million0$0
Sloan-Kettering Inst Can ResearchNew York, NY2$5.2 million0$0
Harvard University D/b/a Harvard School of Public HealthBoston, MA3$5.1 million0$0
J. David Gladstone InstitutesSan Francisco, CA5$4.8 million0$0
Rutgers Biomedical and Health SciencesNewark, NJ4$4.7 million0$0
University of WashingtonSeattle, WA5$4.7 million0$0
Albert Einstein College of MedicineBronx, NY5$4.6 million0$0
Purdue UniversityWest Lafayette, IN5$4.6 million0$0
Carnegie Mellon UniversityPittsburgh, PA3$4.3 million0$0
University of Colorado DenverAurora, CO5$4.3 million0$0
Rbhs-Robert Wood Johnson Medical SchoolPiscataway, NJ7$4.2 million0$0
Scripps Research Institute, theLa Jolla, CA3$4.1 million0$0
Georgetown UniversityWashington, DC4$4.1 million0$0
Ipaces, LLCClifton Park, NY1$4.1 million0$0
Vanderbilt University Medical CenterNashville, TN4$3.9 million0$0
Univ of North Carolina Chapel HillChapel Hill, NC6$3.7 million0$0
Institute for Molecular MedicineHuntington Beach, CA1$3.6 million0$0
Seattle Inst for Biomedical/clinical ResSeattle, WA3$3.5 million0$0
Thomas Jefferson UniversityPhiladelphia, PA7$3.5 million0$0
SUNY at BuffaloAmherst, NY5$3.5 million0$0
Marine Biological LaboratoryWoods Hole, MA3$3.5 million0$0
Dartmouth CollegeHanover, NH2$3.5 million0$0
Sinopia Biosciences, Inc.San Diego, CA1$3.4 million0$0
University of Maryland BaltimoreBaltimore, MD5$3.3 million0$0
Medical University of South CarolinaCharleston, SC6$3.3 million0$0
University of Miami School of MedicineCoral Gables, FL1$3.2 million0$0
Utah State UniversityLogan, UT3$3.1 million0$0
Mayo Clinic JacksonvilleJacksonville, FL4$3.1 million0$0
Sri InternationalMenlo Park, CA2$3 million0$0
Lovelace Biomedical Research InstituteAlbuquerque, NM2$3 million0$0
Amydis Diagnostics, Inc.La Jolla, CA1$3 million0$0
Neurodex INCArlington, MA1$2.9 million0$0
University of ArizonaTucson, AZ3$2.9 million0$0
University of ChicagoChicago, IL2$2.9 million0$0
Teachers College, Columbia UniversityNew York, NY1$2.9 million0$0
ST. Joseph's Hospital and Medical CenterPhoenix, AZ4$2.9 million0$0
Indiana University IndianapolisIndianapolis, IN2$2.8 million0$0
Texas A&m University Health Science CTRCollege Station, TX3$2.8 million0$0
Tufts University BostonBoston, MA1$2.7 million0$0
Nathan S. Kline Institute for Psych ResOrangeburg, NY1$2.7 million0$0
Texas A&m Agrilife ResearchCollege Station, TX2$2.6 million0$0
Rutgers University New BrunswickNew Brunswick, NJ3$2.6 million0$0
Barron Associates, Inc.Charlottesville, VA2$2.5 million0$0
University of Texas at AustinAustin, TX3$2.5 million0$0
SUNY at BinghamtonBinghamton, NY1$2.5 million0$0
Boston Children's HospitalBoston, MA2$2.5 million0$0
Cedars-Sinai Medical CenterLos Angeles, CA1$2.4 million0$0
University of Connecticut SCH of Med/dntFarmington, CT3$2.3 million0$0
Banner HealthPhoenix, AZ1$2.3 million0$0
Translational Genomics Research InstPhoenix, AZ1$2.3 million0$0
San Diego Biomedical Research InstituteSan Diego, CA2$2.1 million0$0
Children's Hosp of PhiladelphiaPhiladelphia, PA1$2.1 million0$0
Great Lakes NeurotechnologiesIndependence, OH2$1.9 million0$0
Automated Imaging Diagnostics, LLCGainesville, FL2$1.9 million0$0
Harvard Medical SchoolBoston, MA3$1.9 million0$0

Funding by fiscal year

Fiscal yearNIH awardsNIH amountNSF awardsNSF amount
2025358$184,057,6490$0
2024390$194,578,8170$0
2023385$205,469,4250$0
2022373$191,703,3430$0
2021360$176,632,8380$0

Open federal funding opportunities

From Grants.gov: notices that funded awards in this table, and open notices on the same agency and assistance listing.

Open opportunityNumberAgencyListingClosesAward ceilingWhy it matches
Change of Recipient Organization (Type 7 Parent Clinical Trial Optional)PA-24-254NIHJuly 12, 2027Not listedNotice number printed on 6 awards here
Mentored Clinical Scientist Research Career Development Award (Parent K08 Independent Clinical Trial Not Allowed)PA-24-182NIHMay 8, 2027Not listedNotice number printed on 2 awards here
Mentored Patient-Oriented Research Career Development Award (Parent K23 Independent Clinical Trial Required)PA-24-184NIHMay 8, 2027Not listedNotice number printed on 1 award here
NIDCD Early Career Research(ECR) Award (R21 Clinical Trial Optional)PAR-25-120NIHOctober 15, 2027Not listedNotice number printed on 1 award here
Functional Target Validation for Alzheimer's Disease-Related DementiasRFA-NS-26-034NIH93.853November 6, 2026Not listedSame assistance listing 93.853 as 574 awards here
Clinical Trials and Ancillary Studies Conducted within NIH-Funded Clinical Trial Research Networks (UG3/UH3 - Clinical Trial Required)PAR-27-007NIH93.853November 10, 2026Not listedSame assistance listing 93.853 as 574 awards here
Amyotrophic Lateral Sclerosis (ALS) Intermediate Patient Population Expanded Access (U01 Clinical Trial Required)RFA-NS-26-001NIH93.853November 10, 2026Not listedSame assistance listing 93.853 as 574 awards here
Genomic and Biologic Therapies for ADRD (U01 Clinical Trial Optional)RFA-NS-26-030NIH93.853November 10, 2026Not listedSame assistance listing 93.853 as 574 awards here
Ethical, Legal and Social Implications (ELSI) Exploratory/Developmental Research Grant (R21 Clinical Trial Optional)PAR-25-369NIH93.853November 18, 2026Not listedSame assistance listing 93.853 as 574 awards here
Ethical, Legal and Social Implications (ELSI) Research (R01 Clinical Trial Optional)PAR-25-371NIH93.853November 18, 2026Not listedSame assistance listing 93.853 as 574 awards here
NIH StrokeNet Clinical Trials and Biomarker Studies for Stroke Treatment, Recovery, and Prevention (UG3/UH3 Clinical Trial Optional)PAR-25-052NIH93.853November 19, 2026Not listedSame assistance listing 93.853 as 574 awards here
HEAL Initiative: Pain Research Enhancement Program (PREP) (R15 Clinical Trial Optional)RFA-AT-25-003NIH93.853November 23, 2026$375,000Same assistance listing 93.853 as 574 awards here
Maximizing the Scientific Value of Data Generated by the Environmental Influences on Child Health Outcomes (ECHO) Program: Ruth L. Kirschstein National Research Service Award (NRSA) Individual Postdoctoral Fellowship (F32)RFA-OD-27-008NIH93.853December 2, 2026Not listedSame assistance listing 93.853 as 574 awards here
Emerging Global Leader Award (K43 Independent Clinical Trial Required)PAR-24-295NIH93.853December 3, 2026Not listedSame assistance listing 93.853 as 574 awards here
Emerging Global Leader Award (K43 Independent Clinical Trial Not Allowed)PAR-24-296NIH93.853December 3, 2026Not listedSame assistance listing 93.853 as 574 awards here
NIH Research Software Engineer (RSE) Award (R50 Clinical Trials Not Allowed)RFA-OD-24-011NIH93.853December 4, 2026Not listedSame assistance listing 93.853 as 574 awards here
Academic Research Enhancement Award (AREA) for Undergraduate-Focused Institutions (R15 Clinical Trial Required)PAR-24-214NIH93.853January 7, 2027$375,000Same assistance listing 93.853 as 574 awards here
HEAL Initiative: Studies to Enable Analgesic Discovery (R61/R33 - Clinical Trial Not Allowed)RFA-NS-25-023NIH93.853January 15, 2027$350,000Same assistance listing 93.853 as 574 awards here
HEAL Initiative: Integrative Management of Chronic Pain and OUD for Whole Recovery (IMPOWR): Research Centers (RM1 Clinical Trial Required)RFA-DA-28-011NIH93.853January 26, 2027Not listedSame assistance listing 93.853 as 574 awards here
HEAL Initiative: Integrative Management of chronic Pain and OUD for Whole Recovery (IMPOWR) - Building Engagement, Assistance, Capacity, Outreach, and Networks (BEACON) Center (U2C Clinical Trial Not Allowed)RFA-DA-28-012NIH93.853January 26, 2027Not listedSame assistance listing 93.853 as 574 awards here

Updated November 3, 2026. Read from NIH RePORTER ExPORTER and NSF Award Search. Published by NIH and NSF as U.S. government data. NIH awards are fiscal years 2021 to 2025 (NIH files published to 2026-07-09); NSF awards are fiscal years 2022 to 2026 (NSF files published to 2026-11-02). NIH amounts are the total cost of each fiscal year in the window; NSF amounts are the funds obligated in the window. Organizations are matched on the UEI. Open opportunities come from Grants.gov and match on agency and assistance listing number, and on the notice number NIH prints on an award. Free to reuse with credit to SpecStream under CC BY 4.0. Spot a wrong value? Write to [email protected] with the link to this page.