| The University of Tennessee Foundat Ion Inc | 501(c)(3) | 2001 | $344.8 million | $1.26 billion | 2025-06 |
| Education Loan Finance Inc | 501(c)(3) | 1996 | $152.8 million | $2.03 billion | 2024-12 |
| Webb School of Knoxville | 501(c)(3) | 1957 | $41.1 million | $147.5 million | 2025-05 |
| University of Tennessee Athletics Foundation Inc | 501(c)(3) | 2025 | $40.1 million | $1.3 million | 2025-06 |
| Johnson University | 501(c)(3) | 2016 | $30.3 million | $281.3 million | 2025-06 |
| Christian Academy of Knoxville Inc | 501(c)(3) | 1978 | $21.3 million | $27.3 million | 2025-06 |
| College and University Professional Association for Human Resources | 501(c)(3) | 2008 | $9.6 million | $26.5 million | 2025-06 |
| Emerald Charter Schools | 501(c)(3) | 2014 | $7.2 million | $7.6 million | 2025-06 |
| Tnachieves | 501(c)(3) | 2011 | $6.6 million | $1.3 million | 2025-06 |
| The Tau Beta Pi Association Inc | 501(c)(3) | 1949 | $6.1 million | $51.3 million | 2025-07 |
| Rivers Edge Christian Academy | 501(c)(3) | 2000 | $3.8 million | $2.4 million | 2025-06 |
| Knox Education Foundation | 501(c)(3) | 2021 | $3.6 million | $7.9 million | 2025-06 |
| Pellissippi State Community College Foundation | 501(c)(3) | 1983 | $3.3 million | $29.4 million | 2025-06 |
| Paideia Academy | 501(c)(3) | 2004 | $2.4 million | $4.8 million | 2025-06 |
| Knoxville Jewish Alliance Inc | 501(c)(3) | 1967 | $2.4 million | $4.1 million | 2025-12 |
| Cherokee Farm Development Corporation | 501(c)(3) | 2014 | $1.9 million | $3.8 million | 2025-06 |
| Knoxville Montessori School | 501(c)(3) | 1966 | $1.6 million | $2.6 million | 2025-06 |
| Concensio Collective Inc | 501(c)(3) | 2015 | $1.4 million | $747,097 | 2024-12 |
| Leadership Knoxville Inc | 501(c)(3) | 1985 | $1.4 million | $2.8 million | 2025-06 |
| East Tennessee Economic Development Agency Inc | 501(c)(3) | 1986 | $1.4 million | $5.6 million | 2025-09 |
| West High School Athletic Council Inc | 501(c)(3) | 2017 | $1.1 million | $406,923 | 2025-06 |
| Knoxville College | 501(c)(3) | 1944 | $1.1 million | $3.1 million | 2024-06 |
| Knoxville Entrepreneur Center | 501(c)(3) | 2014 | $991,337 | $449,178 | 2025-06 |
| Three3 Inc | 501(c)(3) | 2014 | $956,892 | $115,656 | 2024-12 |
| Alpha Epsilon House Corporation of Kappa Delta Sorority | 501(c)(7) | 2014 | $926,562 | $5.6 million | 2025-06 |
| E3 School Support Inc | 501(c)(3) | 2019 | $803,500 | $954,584 | 2025-12 |
| Electrician Training Academy at Knoxville | 501(c)(3) | 1971 | $770,797 | $826,105 | 2024-12 |
| Peer Academy | 501(c)(3) | 2017 | $651,655 | $2.3 million | 2025-09 |
| Kids Place at Sequoyah Inc | 501(c)(3) | 1996 | $442,276 | $185,683 | 2025-06 |
| Pi Kappa Alpha Fraternity | 501(c)(7) | 1941 | $407,628 | $3,986 | 2025-06 |
| Chesterton Academy of Saint Margaret Clitherow | 501(c)(3) | 2023 | $391,881 | $178,931 | 2025-06 |
| Partners for Children | 501(c)(3) | 1989 | $381,606 | $412,864 | 2024-12 |
| West End Christian School | 501(c)(3) | 1988 | $354,882 | $389,311 | 2025-06 |
| Blue Grass Elementary Pto | 501(c)(3) | 2015 | $348,081 | $289,609 | 2026-06 |
| Two Bikes | 501(c)(3) | 2022 | $343,964 | $101,031 | 2025-12 |
| Knox Makers | 501(c)(3) | 2014 | $324,161 | $447,529 | 2025-12 |
| Jireh Homeschool Cooperative | 501(c)(3) | 2024 | $319,360 | $91,851 | 2026-06 |
| College Athletic Trainers Society | 501(c)(6) | 2003 | $291,405 | $695,516 | 2025-12 |
| Knox Forest School | 501(c)(3) | 2021 | $284,687 | $5,240 | 2024-12 |
| Giving Tree Montessori | 501(c)(3) | 1980 | $276,672 | $32,982 | 2025-12 |
| American Research Universities - Human Resource Institute | 501(c)(3) | 2019 | $270,369 | $368,324 | 2025-06 |
| Alpha Gamma Delta Fraternity | 501(c)(7) | 1941 | $263,785 | $34,042 | 2025-06 |
| Friends of Literacy Inc | 501(c)(3) | 1992 | $250,215 | $115,046 | 2025-12 |
| Rocky Hill Elementary School Foundation | 501(c)(3) | 2012 | $233,406 | $119,605 | 2026-06 |
| Hardin Valley Academy Athletic Council | 501(c)(3) | 2009 | $198,416 | $145,099 | 2025-06 |
| Knoxville Rotary Club Student Loan Fund Inc | 501(c)(3) | 1942 | $195,456 | $2 million | 2025-06 |
| A 1 Learning Connections | 501(c)(3) | 2014 | $192,772 | $54,239 | 2024-12 |
| Halls Band Boosters Inc | 501(c)(3) | 2005 | $177,455 | $62,001 | 2026-05 |
| Tennessee Alpha Alumni and Volunteer Corporation | 501(c)(7) | 2020 | $172,883 | $2 million | 2025-06 |
| Pavilion Society Charitable Foundation Inc | 501(c)(3) | 2013 | $158,024 | $1.3 million | 2025-12 |
| Sequoyah Elementary Foundation | 501(c)(3) | 2006 | $116,745 | $229,100 | 2024-05 |
| Northshore Elementary School Parent Teacher Organization Inc | 501(c)(3) | 2024 | $112,752 | $64,485 | 2025-06 |
| Immaculate Heart of Mary Hybrid Cooperative | 501(c)(3) | 2025 | $98,819 | $1,987 | 2025-06 |
| Sequoyah Elementary Parent-Teacher Organization | 501(c)(3) | 2018 | $96,906 | $66,699 | 2026-06 |
| West High School Foundation | 501(c)(3) | 1996 | $94,786 | $78,807 | 2025-06 |
| Immanuel Community School Inc | 501(c)(3) | 2024 | $94,666 | $68,569 | 2025-06 |
| Bearden High School Foundation | 501(c)(3) | 1997 | $89,316 | $134,385 | 2025-06 |
| Dayspring Christian Academy | 501(c)(3) | 2020 | $85,664 | $459,922 | 2026-06 |
| Parent Booster USA Inc | 501(c)(3) | 2005 | $85,108 | $94,864 | 2025-06 |
| Farragut High School Dance Team Boosters | 501(c)(3) | 2017 | $82,099 | $3,369 | 2025-06 |
| Mill Creek Elementary Pto | 501(c)(3) | 2023 | $81,214 | $65,720 | 2025-06 |
| Al Lotts Elementary Pto | 501(c)(3) | 2023 | $79,052 | $36,881 | 2025-06 |
| Bearden Middle School Foundation Inc | 501(c)(3) | 2018 | $78,745 | $101,966 | 2025-06 |
| Youth Outreach in Science Technology Engineering and Mathema | 501(c)(3) | 2018 | $78,338 | $22,796 | 2025-07 |
| Twentieth Street House Corporation | 501(c)(2) | 2014 | $76,497 | $2 million | 2025-06 |
| Thursday Connection | 501(c)(3) | 2004 | $71,559 | $87,566 | 2024-12 |
| Farragut Middle School Pto | 501(c)(3) | 2015 | $69,156 | $7,950 | 2026-06 |
| Hardin Valley Elementary School Pto | 501(c)(3) | 2018 | $67,575 | $8,855 | 2025-06 |
| Seed International Inc | 501(c)(3) | 2018 | $66,044 | $78,870 | 2024-12 |
| Farragut High School Education Foundation Inc | 501(c)(3) | 1996 | $64,774 | $50,956 | 2025-06 |
| Parent Booster USA Inc | 501(c)(3) | 2005 | $60,431 | $44,500 | 2026-06 |
| West Hills Elementary School Wolf Pack Foundation | 501(c)(3) | 2020 | $60,204 | $62,648 | 2025-06 |
| Cumberland Classical Home Centered Educators | 501(c)(3) | 2019 | $59,194 | $35,460 | 2025-12 |
| Knoxville Central High School Athletics Foundation | 501(c)(3) | 2016 | $47,165 | $18,560 | 2025-12 |
| Tates School of Discovery Foundation | 501(c)(3) | 2003 | $46,729 | $314,670 | 2024-12 |
| Brickey Elementary School Pto | 501(c)(3) | 2001 | $43,790 | $61,196 | 2025-06 |
| Rotary Club of Maryville Foundation | 501(c)(3) | 2013 | $43,411 | $70,641 | 2025-06 |
| Bearden High School Parent Teacher Student Organization | 501(c)(3) | 2007 | $42,772 | $70,902 | 2025-06 |
| Hardin Valley Middle School Parent Teacher Organization | 501(c)(3) | 2018 | $40,145 | $5,178 | 2026-06 |
| Bearden High School Band Boosters | 501(c)(3) | 2006 | $31,484 | $63,195 | 2026-06 |
| Veterinary Bookstore of Tennessee College of Veterinary Medicine | 501(c)(3) | 1981 | $29,253 | $61,080 | 2023-04 |
| Tennessee Art Education Association | 501(c)(3) | 2006 | $26,755 | $67,867 | 2025-07 |
| Ritta Elementary School Parent Teacher Organization | 501(c)(3) | 2016 | $26,475 | $51,616 | 2026-05 |
| Knox County Retired Teachers Association Scholarship Foundation | 501(c)(3) | 1994 | $25,493 | $169,374 | 2024-12 |
| Society of Fire Protection Engineers | 501(c)(3) | 2014 | $25,334 | $538,961 | 2024-12 |
| Vols in Turf Alumni | 501(c)(3) | 2024 | $12,340 | $8,510 | 2025-12 |
| Johnson University | 501(c)(3) | 2016 | $11,043 | $79,393 | 2025-06 |
| College and University Professional Association for Human Services | 501(c)(3) | 2008 | $7,750 | $45,143 | 2025-06 |
| Knox County Library Foundation | 501(c)(3) | 2007 | $7,739 | $303,674 | 2024-12 |
| Tennessee Geographic Alliance Inc | 501(c)(3) | 1988 | $4,849 | $173,558 | 2025-12 |
| Halls Alumni Association Inc | 501(c)(3) | 2011 | $4,326 | $7,609 | 2025-12 |
| West High School Ptso | 501(c)(3) | 2012 | $338 | $19,004 | 2025-06 |
| 1 Kidz Academy | 501(c)(3) | 2026 | | | |
| 5-Star Education Foundation | 501(c)(3) | 2016 | $0 | $0 | 2025-12 |
| 901 Reasons | 501(c)(3) | 2024 | $0 | $0 | 2024-12 |
| Access Cultural Diversity | 501(c)(3) | 2023 | | $4,990 | 2025-12 |
| Ace Mentor Program of America Inc | 501(c)(3) | 2006 | $0 | $0 | 2025-06 |
| Adopt-A-School Partnerships Inc | 501(c)(3) | 2017 | $0 | $0 | 2025-06 |
| Alpha Omega Epsilon | 501(c)(7) | 2022 | $0 | $0 | 2025-08 |
| Alpha Pi Omega Foundation | 501(c)(3) | 1993 | $0 | $0 | 2025-12 |
| Amherst Elementary School Parent Teacher Organization | 501(c)(3) | 2023 | $0 | $0 | 2026-06 |
| Anago Impact | 501(c)(3) | 2026 | | | |
| Anna Bell Frazier Memorial Foundati On | 501(c)(3) | 2026 | | | |
| Arthur Hale Trust Ua | 501(c)(3) | 1996 | | $1.5 million | 2025-12 |
| Assoc of Independent School Librarians Inc | 501(c)(3) | 2013 | $0 | $0 | 2025-12 |
| Beacon Academy of Knoxville | 501(c)(3) | 2026 | | | |
| Bearden Elementary Parent Student Organization | 501(c)(3) | 2004 | $0 | $0 | 2026-07 |
| Bearden Lady Bulldog Soccer | 501(c)(3) | 2020 | $0 | $0 | 2026-06 |
| Bearden Learning Center | 501(c)(3) | 2025 | | | |
| Beauty Professional Awards Foundati On | 501(c)(3) | 2026 | | | |
| Beta Housing of Knoxville Inc | 501(c)(7) | 2007 | $0 | $0 | 2025-12 |
| Beta Theta Boule Foundation | 501(c)(3) | 2011 | $0 | $0 | 2025-12 |
| Bill Cutright Scholarship Foundatio N | 501(c)(3) | 2026 | $0 | $0 | 2025-12 |
| Bobcat Pride & Tradition Inc | 501(c)(3) | 2016 | $0 | $0 | 2023-12 |
| CCV Foundation Inc | 501(c)(3) | 2025 | | | |
| Care 365 Christmas Care Fund | 501(c)(3) | 2006 | $0 | $0 | 2025-12 |
| Carolyn M Cate Foundation Inc | 501(c)(3) | 2014 | | $72,154 | 2025-12 |
| Carter Elementary Parent Teachers Organization Foundation | 501(c)(3) | 2017 | $0 | $0 | 2025-05 |
| Catholic Dads | 501(c)(3) | 2024 | $0 | $0 | 2025-12 |
| Cedar Bluff Kids Inc | 501(c)(3) | 2001 | | | |
| Center for English and Integration Services | 501(c)(3) | 2017 | $0 | $0 | 2025-12 |
| Central High School Foundation Inc | 501(c)(3) | 2001 | $0 | $0 | 2025-12 |
| Cheo of Greater Knoxville Area | 501(c)(3) | 2010 | $0 | $0 | 2025-12 |
| Chilhowee Intermediate Pto | 501(c)(3) | 2024 | $0 | $0 | 2026-06 |
| Christian Association for Deaf Education | 501(c)(3) | 2014 | $0 | $0 | 2025-12 |
| Christopher Willett Life Skills Partners | 501(c)(3) | 2023 | $0 | $0 | 2023-06 |
| Clinton Senior High Alumni Association Inc | 501(c)(3) | 2025 | | | |
| College Bound TN Inc | 501(c)(3) | 2026 | $0 | $0 | 2025-12 |
| College and University Professional Association for Human Resources | 501(c)(3) | 2008 | $0 | $0 | 2025-06 |
| College and University Professional Association for Human Resources | 501(c)(3) | 2008 | $0 | $0 | 2025-06 |
| College and University Professional Association for Human Resources | 501(c)(3) | 2008 | $0 | $0 | 2025-06 |
| College and University Professional Association for Human Resources | 501(c)(3) | 2008 | $0 | $0 | 2025-06 |
| College and University Professional Association for Human Resources | 501(c)(3) | 2008 | $0 | $0 | 2025-06 |
| College and University Professional Association for Human Resources | 501(c)(3) | 2008 | $0 | $0 | 2025-06 |
| College and University Professional Association for Human Resources | 501(c)(3) | 2008 | $0 | $0 | 2025-06 |
| College and University Professional Association for Human Resources | 501(c)(3) | 2008 | $0 | $0 | 2025-06 |
| College and University Professional Association for Human Resources | 501(c)(3) | 2008 | $0 | $0 | 2025-06 |
| College and University Professional Association for Human Resources | 501(c)(3) | 2008 | $0 | $0 | 2025-06 |
| College and University Professional Association for Human Resources | 501(c)(3) | 2008 | $0 | $0 | 2025-06 |
| College and University Professional Association for Human Resources | 501(c)(3) | 2008 | $0 | $0 | 2025-06 |
| College and University Professional Association for Human Resources | 501(c)(3) | 2008 | $0 | $0 | 2025-06 |
| College and University Professional Association for Human Resources | 501(c)(3) | 2008 | $0 | $0 | 2025-06 |
| College and University Professional Association for Human Services | 501(c)(3) | 2008 | $0 | $0 | 2025-06 |
| College and University Professional Association for Human Services | 501(c)(3) | 2008 | $0 | $0 | 2025-06 |
| College and University Professional Association for Human Services | 501(c)(3) | 2008 | $0 | $0 | 2025-06 |
| College and University Professional Association for Human Services | 501(c)(3) | 2008 | $0 | $0 | 2025-06 |
| College and Universtiy Professional Association for Human Resources | 501(c)(3) | 2008 | $0 | $0 | 2025-06 |
| Community Tutoring | 501(c)(3) | 2022 | $0 | $0 | 2025-12 |
| Council of Manorial Lords | 501(c)(3) | 2025 | | | |
| Dive Into the Ocean | 501(c)(3) | 2014 | $0 | $0 | 2024-12 |
| Dogwood Elementary School Pto | 501(c)(3) | 1998 | $0 | $0 | 2026-06 |
| East Tennessee Computer Society | 501(c)(3) | 1998 | $0 | $0 | 2025-12 |
| Education Excellence Initiative | 501(c)(3) | 2021 | $0 | $0 | 2025-12 |
| Experimental Aircraft Association | 501(c)(3) | 2017 | $0 | $0 | 2025-12 |
| Eythos Foundation | 501(c)(3) | 2025 | $0 | $0 | 2025-12 |
| Farragut High Njrotc Booster Club | 501(c)(3) | 2016 | $0 | $0 | 2024-05 |
| Farragut High School Golf Team | 501(c)(3) | 2018 | $0 | $0 | 2025-12 |
| Farragut High School Ptso | 501(c)(3) | 2006 | $0 | $0 | 2025-06 |
| Farragut High School Track Booster Club Inc | 501(c)(3) | 2017 | $0 | $0 | 2025-06 |
| Fbi Knoxville Citizens Academy Alumni Association | 501(c)(3) | 2014 | $0 | $0 | 2025-12 |
| First Chairs Club Inc | 501(c)(3) | 2016 | $0 | $0 | 2025-12 |
| Flagship Robotics 3140 Foundation Inc | 501(c)(3) | 2017 | $0 | $0 | 2026-06 |
| For the Love of Reading | 501(c)(3) | 2022 | $0 | $0 | 2025-12 |
| Fort Sanders School Pto | 501(c)(3) | 2018 | $0 | $0 | 2024-07 |
| Fountain City Elementary School Parent Teacher Organization Inc | 501(c)(3) | 2015 | $0 | $0 | 2026-06 |
| Freedom Christian Academy Inc | 501(c)(3) | 2009 | | | |
| Front Page Foundation | 501(c)(3) | 2014 | $0 | $0 | 2025-12 |
| Fulton High School Alumni Association | 501(c)(3) | 2012 | $0 | $0 | 2026-08 |
| GMS Ptso | 501(c)(3) | 2018 | $0 | $0 | 2025-12 |
| Green Hills Learning Center Inc | 501(c)(3) | 2002 | $0 | $0 | 2025-12 |
| Gresham Middle School Foundation Inc | 501(c)(3) | 2014 | $0 | $0 | 2025-12 |
| Gwendolyn Gives Foundation | 501(c)(3) | 2023 | $0 | $0 | 2023-12 |
| Halls Elementary School Parent Teacher Organization | 501(c)(3) | 2015 | $0 | $0 | 2023-12 |
| Halls High School Parent Teacher Organization | 501(c)(3) | 2020 | $0 | $0 | 2026-06 |
| Halls Swim Team | 501(c)(3) | 2018 | $0 | $0 | 2025-06 |
| Hardin Valley Academy Foundation Inc | 501(c)(3) | 2013 | $0 | $0 | 2025-12 |
| Heritage Ffa Alumni and Supporters | 501(c)(3) | 2023 | $0 | $0 | 2025-05 |
| Holston Middle School Parent Teacher Organization | 501(c)(3) | 2024 | $0 | $0 | 2026-06 |
| Honor Sociey of Phi Kappa Phi | 501(c)(3) | 1999 | $0 | $0 | 2026-06 |
| Institute of Spiritual Healing & Armoatherapy Inc | 501(c)(3) | 2023 | $0 | $0 | 2024-12 |
| Isha Foundation Inc | 501(c)(3) | 2007 | $0 | $0 | 2023-12 |
| Karns Elementary Pto | 501(c)(3) | 2024 | $0 | $0 | 2025-06 |
| Karns High School Foundation | 501(c)(3) | 2025 | $0 | $0 | 2025-12 |
| Karns Middle School Foundation | 501(c)(3) | 2019 | $0 | $0 | 2025-12 |
| Knox Climate Watch | 501(c)(3) | 2024 | $0 | $0 | 2025-12 |
| Knox County Schools Blended Preschool Foundation | 501(c)(3) | 2022 | $0 | $0 | 2025-06 |
| Knoxville Academy of Medicine Womans Auxiliary | 501(c)(4) | 1972 | $0 | $0 | 2025-05 |
| Knoxville East High School Alumni Association | 501(c)(7) | 2011 | $0 | $0 | 2025-12 |
| Knoxville Electric Vehicle Association | 501(c)(3) | 2021 | $0 | $0 | 2025-12 |
| Knoxville Rainbow Library | 501(c)(3) | 2025 | $0 | $0 | 2025-12 |
| Knoxville Suzuki Academy Foundation | 501(c)(3) | 2026 | | | |
| Knoxville Tva Employees Credit Union Foundation | 501(c)(3) | 2009 | | $175,807 | 2025-12 |
| Lance S Fund | 501(c)(3) | 2025 | $0 | $0 | 2025-12 |
| Larry Corum Scholarship Fund Inc | 501(c)(3) | 2016 | $0 | $0 | 2025-12 |
| Lewis Institute of Media & Entertainment Technology | 501(c)(3) | 2024 | | | |
| Lonsdale Elementary Ptfo | 501(c)(3) | 2024 | $0 | $0 | 2026-06 |
| Lumen Academy | 501(c)(3) | 2018 | $0 | $0 | 2025-12 |
| MR PS Foundation | 501(c)(3) | 2011 | $0 | $0 | 2025-12 |
| Mead Montessori Pto | 501(c)(3) | 2014 | $0 | $0 | 2026-05 |
| Mhes Rocket Foundation | 501(c)(3) | 2023 | $0 | $0 | 2025-06 |
| Michael Bradley Benton Memorial Educational Scholarship Fund | 501(c)(3) | 2007 | | $5,094 | 2025-12 |
| Midnight Discovery Inc | 501(c)(3) | 2018 | $0 | $0 | 2025-12 |
| Motorcycle Effect | 501(c)(3) | 2025 | | | |
| Mount Olive Elementary Pto | 501(c)(3) | 2017 | $0 | $0 | 2025-07 |
| Nanas Books Foundation | 501(c)(3) | 2022 | $0 | $0 | 2025-12 |
| National Accrediting Commission for Martial Arts Corp | 501(c)(3) | 2006 | $0 | $0 | 2025-12 |
| National Institute of Governmental Purchasing Inc | 501(c)(3) | 1945 | $0 | $0 | 2025-12 |
| National Society of Black Engineers University of TN KN Student Chap | 501(c)(3) | 2025 | $0 | $0 | 2025-07 |
| Negev Institue | 501(c)(3) | 2024 | | $26,430 | 2024-12 |
| North America Chinese Association for Nutrition | 501(c)(3) | 2021 | $0 | $0 | 2025-12 |
| Northwest Pto | 501(c)(3) | 2023 | $0 | $0 | 2026-06 |
| Oakmont Education Corporation | 501(c)(3) | 2019 | | | |
| Opportunity Youth Network TN | 501(c)(3) | 2026 | $0 | $0 | 2026-06 |
| Parent Booster USA Inc | 501(c)(3) | 2005 | $0 | $0 | 2025-08 |
| Phi Eta Sigma National Honor Society Inc | 501(c)(3) | 2014 | | | |
| Pta Tennessee Congress of Parents Teachers Inc | 501(c)(3) | 1980 | $0 | $0 | 2026-06 |
| Pto Bearden Middle | 501(c)(3) | 2023 | $0 | $0 | 2026-06 |
| Reach Them To Teach Them | 501(c)(3) | 2011 | $0 | $0 | 2025-12 |
| Reading League Tennessee | 501(c)(3) | 2024 | $0 | $0 | 2025-06 |
| Roadrunner Booster Club | 501(c)(3) | 2009 | $0 | $0 | 2023-12 |
| Rocky Top Chess Inc | 501(c)(3) | 2019 | $0 | $0 | 2026-08 |
| Rotary Club of Knoxville Volunteer Tennessee USA | 501(c)(3) | 2013 | $0 | $0 | 2025-06 |
| Scarecrow Foundation Inc | 501(c)(3) | 2011 | $0 | $0 | 2025-12 |
| Schools of Influence Education Foundation | 501(c)(3) | 2010 | $0 | $0 | 2025-12 |
| Scott Impellizeri Memorial Scholarship Inc | 501(c)(3) | 2014 | $0 | $0 | 2026-06 |
| Seniors for Creative Learning | 501(c)(3) | 2023 | $0 | $0 | 2025-12 |
| Shannondale Parent Teacher Organization | 501(c)(3) | 2012 | $0 | $0 | 2024-05 |
| Show Us Your Ways | 501(c)(3) | 2019 | $0 | $0 | 2025-12 |
| Smoky Mountain Home Education Association | 501(c)(3) | 2004 | $0 | $0 | 2025-12 |
| Society of Hispanic Professional Engineers University of Tennessee | 501(c)(3) | 2022 | $0 | $0 | 2024-06 |
| Society of Women Engineers | 501(c)(3) | 2012 | $0 | $0 | 2026-06 |
| Soldiers of Christ Ministries Inc | 501(c)(3) | 2010 | $0 | $0 | 2025-12 |
| Sons of Thunder Academy | 501(c)(3) | 2026 | | | |
| South College School of Pharamcy PH I Lambda Sigma Delta Psi | 501(c)(3) | 2026 | $0 | $0 | 2025-09 |
| South College System Foundation Inc | 501(c)(3) | 2021 | $0 | $0 | 2024-09 |
| South Doyle Band Boosters Association Inc | 501(c)(3) | 2009 | $0 | $0 | 2025-12 |
| South Doyle High School Chorus Booster Club | 501(c)(3) | 2018 | $0 | $0 | 2026-06 |
| South Doyle High School Soccer Booster Club | 501(c)(3) | 2025 | $0 | $0 | 2025-06 |
| South Doyle Middle School Ptso | 501(c)(3) | 2021 | $0 | $0 | 2026-06 |
| Southern Appalachian Science and Engineering Fair Incorporated | 501(c)(3) | 2006 | $0 | $0 | 2025-12 |
| Stanford Eisenberg Knoxville Jewishday School | 501(c)(3) | 2009 | | | |
| Stephen W Hackney Foundation Inc | 501(c)(3) | 2025 | $0 | $0 | 2025-12 |
| Sterchi Elementary School Pto | 501(c)(3) | 2024 | $0 | $0 | 2025-06 |
| Student Bar Association | 501(c)(7) | 2014 | $0 | $0 | 2025-06 |
| Sunnyview Primary Pto | 501(c)(3) | 2022 | $0 | $0 | 2026-06 |
| Sunrise Learning Foundation | 501(c)(3) | 2024 | $0 | $0 | 2025-12 |
| Sunshine Ambassadors Inc | 501(c)(3) | 2009 | $0 | $0 | 2025-12 |
| Tackle for Change | 501(c)(3) | 2025 | | | |
| Taiwanese Chamber of Commerce of Knoxville | 501(c)(3) | 2025 | $0 | $0 | 2025-12 |
| Teaming To Educate for Agricultural Mastery | 501(c)(3) | 2024 | $0 | $0 | 2025-12 |
| Tenn Assoc of Independence Liberal Art Colleges for Teachers Educatio | 501(c)(3) | 2024 | | | |
| Tennessee Alpha Alumni Association of Sigma Alpha Epsilon | 501(c)(7) | 2024 | $0 | $0 | 2025-10 |
| Tennessee Association for Student Success and Retention | 501(c)(3) | 2018 | $0 | $0 | 2025-06 |
| Tennessee Health Science Library Association | 501(c)(3) | 2024 | $0 | $0 | 2024-06 |
| Tennessee Lions Learning Retreat Inc | 501(c)(3) | 2008 | $0 | $0 | 2026-06 |
| Tennessee Senior America Pageant | 501(c)(3) | 2018 | $0 | $0 | 2025-12 |
| Tennessee Track and Cross Country Coaches Association | 501(c)(3) | 2023 | $0 | $0 | 2024-12 |
| The Beaumont Magnet Academy Foundation | 501(c)(3) | 2019 | $0 | $0 | 2023-12 |
| The Book Observer Limited | 501(c)(3) | 2022 | $0 | $0 | 2023-12 |
| The Healing Bridge | 501(c)(3) | 2026 | | | |
| The Karns High School Football Boosters Club | 501(c)(3) | 2009 | $0 | $0 | 2025-12 |
| Theodorus Chapter of Alpha Rho Chi Fraternity | 501(c)(7) | 2016 | $0 | $0 | 2023-12 |
| Thomas Tank Strickland Foundation | 501(c)(3) | 2015 | $0 | $0 | 2025-10 |
| Transactions the Tennessee Journal of Business Law Inc | 501(c)(3) | 2004 | $0 | $0 | 2025-12 |
| Treasures From the Sea | 501(c)(3) | 2022 | $0 | $0 | 2025-12 |
| United Class of 1968 | 501(c)(3) | 2022 | $0 | $0 | 2025-12 |
| University of Tennessee College of Veterinary Medicine Class of 2028 | 501(c)(3) | 2025 | $0 | $0 | 2024-12 |
| Urban Dove Tennessee | 501(c)(3) | 2025 | $0 | $0 | 2026-06 |
| Utcvm Class of 2024 | 501(c)(3) | 2021 | $0 | $0 | 2024-05 |
| Utcvm Class of 2029 | 501(c)(3) | 2026 | $0 | $0 | 2025-12 |
| Utig Inc | 501(c)(3) | 2018 | $0 | $0 | 2025-12 |
| Vaccination Information Awareness Initiative | 501(c)(3) | 2016 | $0 | $0 | 2023-04 |
| Virelia Foundation | 501(c)(3) | 2026 | | | |
| Virginia Beta Chapter of Sigma Phi Epsilon | 501(c)(7) | 2021 | $0 | $0 | 2025-06 |
| Virginia Research Institute | 501(c)(3) | 2015 | $0 | $0 | 2025-12 |
| Volunteers for Humanity Inc | 501(c)(3) | 2026 | | | |
| West Valley Middle School Education Foundation Inc | 501(c)(3) | 2016 | $0 | $0 | 2025-09 |
| West Valley Middle School Parent Teacher Organization | 501(c)(3) | 2020 | $0 | $0 | 2026-06 |
| Wisdom and Meaning Foundation Inc | 501(c)(3) | 2026 | | | |