Data / Nonprofits / Tennessee / Knoxville
Nonprofits in Knoxville, TN: 2,476 registered with the IRS
2,476 nonprofits are registered with the IRS in Knoxville, TN, 2,063 of them 501(c)(3) charities; the 829 that report revenue took in $6.39 billion. The largest by revenue: University Health System Inc ($1.62 billion), Parkwest Medical Center ($469.8 million), Fort Sanders Regional Medical Center ($423.2 million). Most common causes: religion-related (301), education (279), human services (196).
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The 500 largest by revenue
| Organization | Category | Type | Since | Revenue | Assets | Filing |
|---|---|---|---|---|---|---|
| University Health System Inc | Health care | 501(c)(3) | 1999 | $1.62 billion | $1.32 billion | 2024-12 |
| Parkwest Medical Center | Health care | 501(c)(3) | 1990 | $469.8 million | $289.9 million | 2024-12 |
| Fort Sanders Regional Medical Center | Health care | 501(c)(3) | 2007 | $423.2 million | $249.5 million | 2024-12 |
| East Tennessee Childrens Hospital Association Inc | Health care | 501(c)(3) | 1952 | $413.8 million | $740.4 million | 2025-06 |
| The University of Tennessee Foundat Ion Inc | Education | 501(c)(3) | 2001 | $344.8 million | $1.26 billion | 2025-06 |
| Knoxville Tva Employees Credit Unio | 501(c)(14) | 1952 | $331.4 million | $5.14 billion | 2025-12 | |
| Covenant Health | Health care | 501(c)(3) | 1996 | $235.7 million | $1.96 billion | 2024-12 |
| Methodist Medical Center | Health care | 501(c)(3) | 1960 | $184.4 million | $93.7 million | 2024-12 |
| Morristown Hamblen Hosp | Health care | 501(c)(3) | 1957 | $161.2 million | $109.8 million | 2024-12 |
| Leconte Medical Center | Health care | 501(c)(3) | 1981 | $160.4 million | $87.7 million | 2024-12 |
| Education Loan Finance Inc | Education | 501(c)(3) | 1996 | $152.8 million | $2.03 billion | 2024-12 |
| The Helen Ross McNabb Center | Mental health and crisis intervention | 501(c)(3) | 1953 | $121.1 million | $103.4 million | 2025-06 |
| Cumberland Medical Center Inc | Health care | 501(c)(3) | 1972 | $105.2 million | $82.7 million | 2024-12 |
| Vine International Inc | Health care | 501(c)(3) | 1994 | $58.2 million | $248,676 | 2024-12 |
| East Tenn Human Resource Agency Inc | 501(c)(3) | 1992 | $55.4 million | $27 million | 2025-06 | |
| Fort Loudoun Medical Center | Health care | 501(c)(3) | 1990 | $53.8 million | $27.8 million | 2024-12 |
| Knox Area Rescue Ministries | Housing and shelter | 501(c)(3) | 1964 | $50 million | $55.7 million | 2025-06 |
| Roane County Medical Center | Health care | 501(c)(3) | 2009 | $49.9 million | $49.1 million | 2024-12 |
| Retiree Resource Corp | Public safety, disaster preparedness and relief | 501(c)(3) | 2002 | $46.7 million | $4.4 million | 2025-09 |
| Hillcrest Healthcare Communities Inc | Health care | 501(c)(3) | 1962 | $43.3 million | $35.2 million | 2025-06 |
| Webb School of Knoxville | Education | 501(c)(3) | 1957 | $41.1 million | $147.5 million | 2025-05 |
| University of Tennessee Athletics Foundation Inc | Education | 501(c)(3) | 2025 | $40.1 million | $1.3 million | 2025-06 |
| Claiborne Medical Center | Health care | 501(c)(3) | 2014 | $37 million | $18.5 million | 2024-12 |
| Fort Sanders Perinatal Center | 501(c)(3) | 2007 | $33.3 million | $12.7 million | 2024-12 | |
| Johnson University | Education | 501(c)(3) | 2016 | $30.3 million | $281.3 million | 2025-06 |
| East Tennessee Foundation | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 1963 | $27.7 million | $282.5 million | 2024-12 |
| The H T Hackney Co Emloyee Benefit Plans Trust | 501(c)(9) | 1989 | $27.7 million | $9.5 million | 2025-06 | |
| Covenant Homecare | Health care | 501(c)(3) | 1997 | $25.4 million | $3.3 million | 2024-12 |
| Goodwill Industries - Knoxville Inc | Employment | 501(c)(3) | 1972 | $24.5 million | $51.8 million | 2025-12 |
| Collaborative Composite Solutions Corporation | Human services | 501(c)(3) | 2014 | $24.2 million | $13.8 million | 2025-06 |
| Medic Inc | Health care | 501(c)(3) | 1981 | $22.6 million | $31 million | 2025-04 |
| Thompson Oncology Group Dba Covenant Health Oncology Group | Health care | 501(c)(3) | 1997 | $22.4 million | $9.8 million | 2024-12 |
| Christian Academy of Knoxville Inc | Education | 501(c)(3) | 1978 | $21.3 million | $27.3 million | 2025-06 |
| Positively Living Inc | Human services | 501(c)(3) | 1998 | $21.2 million | $6.1 million | 2025-06 |
| Boys & Girls Clubs in Tennessee | Youth development | 501(c)(3) | 2009 | $19.9 million | $1.8 million | 2024-12 |
| Covenant Living at Shannondale | Human services | 501(c)(3) | 1965 | $19.2 million | $110.6 million | 2025-09 |
| Our Daily Bread of Tennessee Inc | Food, agriculture and nutrition | 501(c)(3) | 1997 | $18.3 million | $3.4 million | 2025-09 |
| Knoxville Leadership Foundation | Religion-related | 501(c)(3) | 1994 | $18.1 million | $22.7 million | 2025-12 |
| Historic Tennessee Theatre Foundation | Arts, culture and humanities | 501(c)(3) | 1996 | $17.9 million | $46.1 million | 2025-12 |
| Bush Brothers & Company Employees Benefit Trust | 501(c)(9) | 1993 | $17.2 million | $623,204 | 2024-12 | |
| Young Mens Christian Association of East Tennessee Inc | Human services | 501(c)(3) | 1938 | $16.9 million | $22 million | 2025-12 |
| Knoxville Zoological Gardens Inc | Animal-related | 501(c)(3) | 1980 | $16.5 million | $64.7 million | 2024-12 |
| Boys & Girls Clubs of the Tennessee Valley | Youth development | 501(c)(3) | 1947 | $15.6 million | $28.2 million | 2025-06 |
| Sertoma Center Inc | 501(c)(3) | 1972 | $15 million | $12.8 million | 2025-06 | |
| National Emergency Assistance Inc | Public safety, disaster preparedness and relief | 501(c)(3) | 2002 | $14.3 million | $2.9 million | 2025-09 |
| Cherokee Country Club | 501(c)(7) | 1942 | $14.2 million | $39.1 million | 2025-03 | |
| Knoxville Convention & Visitors Bureau Inc | Community improvement and capacity building | 501(c)(3) | 2005 | $13.5 million | $17.3 million | 2025-06 |
| Phillips & Jordan Veba Trust | Mutual and membership benefit | 501(c)(9) | 2007 | $13.1 million | $138,830 | 2024-12 |
| National Christian Charitable Foundation Inc | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 2001 | $12.4 million | $14.2 million | 2024-12 |
| Federal Defender Services of Eastern Tennessee | Human services | 501(c)(3) | 1992 | $12.4 million | $654,526 | 2025-09 |
| Shepherds Staff Mission Facilitators Inc | Religion-related | 501(c)(3) | 2002 | $11.8 million | $5.7 million | 2025-05 |
| Emerald Youth Foundation | Youth development | 501(c)(3) | 1992 | $10.6 million | $30.4 million | 2025-12 |
| Helen Ross McNabb Mental Health Foundation Inc | Mental health and crisis intervention | 501(c)(3) | 1972 | $10.5 million | $67.9 million | 2025-06 |
| Interfaith Health Center Inc | Health care | 501(c)(3) | 1991 | $10 million | $15.5 million | 2025-06 |
| College and University Professional Association for Human Resources | Education | 501(c)(3) | 2008 | $9.6 million | $26.5 million | 2025-06 |
| Three Roots Capital | Community improvement and capacity building | 501(c)(3) | 1996 | $9.4 million | $224.3 million | 2025-12 |
| Pat Summitt Foundation | Diseases, disorders and medical disciplines | 501(c)(3) | 2025 | $9.3 million | $8.8 million | 2025-12 |
| Catholic Charities of East Tennessee Inc | 501(c)(3) | 1946 | $8.6 million | $8.2 million | 2025-06 | |
| University of Tennessee Research Foundation | 501(c)(3) | 1958 | $8.5 million | $98.1 million | 2025-06 | |
| The Episcopal School of Knoxville Inc | 501(c)(3) | 1994 | $8.2 million | $19.3 million | 2025-06 | |
| Young-Williams Animal Center of East Tennessee | Animal-related | 501(c)(3) | 2012 | $8 million | $7 million | 2025-06 |
| Fox Den Country Club | 501(c)(7) | 1970 | $8 million | $8.7 million | 2025-12 | |
| The Thompson Cancer Survival Center | 501(c)(3) | 1986 | $7.9 million | $57 million | 2024-12 | |
| Young Womens Christian Association-Knoxville YWCA | Human services | 501(c)(3) | 1942 | $7.7 million | $12.5 million | 2025-12 |
| Harmony Family Center Inc | Human services | 501(c)(3) | 2001 | $7.5 million | $2.4 million | 2025-06 |
| Emerald Charter Schools | Education | 501(c)(3) | 2014 | $7.2 million | $7.6 million | 2025-06 |
| Tnachieves | Education | 501(c)(3) | 2011 | $6.6 million | $1.3 million | 2025-06 |
| Breakthrough Corporation | Housing and shelter | 501(c)(3) | 2000 | $6.6 million | $3.6 million | 2025-06 |
| Ted and Drama Russell Family Foundation | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 2016 | $6.4 million | $107.5 million | 2024-12 |
| Lakeshore Park Conservancy | Recreation and sports | 501(c)(3) | 1996 | $6.4 million | $17.1 million | 2025-06 |
| Habitat for Humanity International Inc | 501(c)(3) | 1987 | $6.2 million | $16.9 million | 2025-06 | |
| The Tau Beta Pi Association Inc | Education | 501(c)(3) | 1949 | $6.1 million | $51.3 million | 2025-07 |
| Legacy Parks Foundation | Recreation and sports | 501(c)(3) | 2006 | $6 million | $6.9 million | 2025-12 |
| City Employees-Knoxville | Public and societal benefit | 501(c)(14) | 1952 | $6 million | $119.1 million | 2025-12 |
| Crown Financial Ministries Inc | Religion-related | 501(c)(3) | 1976 | $5.9 million | $8 million | 2025-03 |
| Senior Citizens Home Assistance Service Inc | Human services | 501(c)(3) | 1972 | $5.8 million | $2.3 million | 2025-06 |
| Hospitality Pantries Inc | Food, agriculture and nutrition | 501(c)(3) | 1995 | $5.8 million | $5.3 million | 2025-12 |
| Southern Alliance for Clean Energy | Environment | 501(c)(3) | 1985 | $5.4 million | $12 million | 2025-12 |
| Greater Knoxville Chamber of Commerce | 501(c)(6) | 1942 | $5.4 million | $3.9 million | 2025-06 | |
| Alcoholism Services of Knoxville Inc | Mental health and crisis intervention | 501(c)(3) | 1978 | $5.3 million | $10.2 million | 2025-12 |
| Knoxville Symphony Society Inc | Arts, culture and humanities | 501(c)(3) | 1950 | $5.3 million | $2.1 million | 2025-05 |
| Knox Housing Partnership Inc | Housing and shelter | 501(c)(3) | 1991 | $5.2 million | $26.6 million | 2025-12 |
| Girl Scout Council of the Southern Appalachians Inc | Youth development | 501(c)(3) | 1934 | $5.1 million | $13.4 million | 2025-09 |
| Big Ears Festival | Arts, culture and humanities | 501(c)(3) | 2016 | $5 million | $3 million | 2025-06 |
| Tnconnect Credit Union | 501(c)(14) | 1952 | $4.8 million | $86 million | 2025-12 | |
| Saving Nature Inc | Environment | 501(c)(3) | 2019 | $4.8 million | $1.9 million | 2025-12 |
| Bicentennial Volunteers | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 1986 | $4.7 million | $29.2 million | 2025-09 |
| New South Credit Union | 501(c)(14) | 1952 | $4.7 million | $86.3 million | 2025-12 | |
| Orthoforum Inc | Community improvement and capacity building | 501(c)(6) | 2013 | $4.6 million | $6 million | 2025-12 |
| Nursing Center at Little Creek | Mental health and crisis intervention | 501(c)(3) | 1956 | $4.5 million | $2 million | 2025-05 |
| East Tennessee Public Communications Corporation | Arts, culture and humanities | 501(c)(3) | 1984 | $4.5 million | $12 million | 2025-06 |
| International Association of Sheet Metal Air Rail & Transportation | Employment | 501(c)(5) | 2015 | $4.4 million | $6.3 million | 2025-08 |
| Arts and Culture Alliance of Greater Knoxville | Arts, culture and humanities | 501(c)(3) | 1976 | $4.3 million | $3.9 million | 2025-06 |
| Restoration House of East Tennessee | Human services | 501(c)(3) | 2007 | $4.2 million | $7.7 million | 2025-12 |
| Clayton Foundation | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 2004 | $4.2 million | $193.5 million | 2024-12 |
| Tennessee 4-H Foundation Inc | 501(c)(3) | 1958 | $4.1 million | $21 million | 2024-12 | |
| Sunshine Services | Human services | 501(c)(3) | 1954 | $4.1 million | $3 million | 2025-06 |
| The Florence Crittenton Agency Inc | 501(c)(3) | 1964 | $4 million | $7.7 million | 2025-06 | |
| Boy Scouts of America | Youth development | 501(c)(3) | 1965 | $3.9 million | $11.8 million | 2025-12 |
| Rivers Edge Christian Academy | Education | 501(c)(3) | 2000 | $3.8 million | $2.4 million | 2025-06 |
| Karns Volunteer Fire Department | Public safety, disaster preparedness and relief | 501(c)(3) | 1979 | $3.8 million | $12.9 million | 2025-12 |
| Bijou Theater Center | 501(c)(3) | 1988 | $3.7 million | $6.8 million | 2025-06 | |
| YWCA Knoxville Real Estate Holding Co | Community improvement and capacity building | 501(c)(3) | 2025 | $3.6 million | $14.3 million | 2025-12 |
| National Christian Charitable Foundation Inc | 501(c)(3) | 2001 | $3.6 million | $17.8 million | 2025-12 | |
| Knox Education Foundation | Education | 501(c)(3) | 2021 | $3.6 million | $7.9 million | 2025-06 |
| Volunteer Ministry Center Inc | Housing and shelter | 501(c)(3) | 1990 | $3.5 million | $13.9 million | 2025-12 |
| Mission of Hope Inc | Human services | 501(c)(3) | 1999 | $3.4 million | $3.7 million | 2025-12 |
| Appalachian Community Fund Inc | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 1988 | $3.3 million | $7.1 million | 2025-06 |
| Pellissippi State Community College Foundation | Education | 501(c)(3) | 1983 | $3.3 million | $29.4 million | 2025-06 |
| Knoxville Museum of Art | Arts, culture and humanities | 501(c)(3) | 1963 | $3.3 million | $12.5 million | 2025-06 |
| Employees of Home Federal Bank of Tennessee F S B Trust | 501(c)(9) | 1996 | $3.1 million | $863,509 | 2024-12 | |
| Bridge Refugee Services Inc | 501(c)(3) | 1983 | $3 million | $1.1 million | 2024-12 | |
| Centro Hispano de East Tennessee | Human services | 501(c)(3) | 2005 | $2.9 million | $1.9 million | 2025-06 |
| International Brotherhood of Teamsters | 501(c)(5) | 1954 | $2.9 million | $2.4 million | 2025-12 | |
| Special Spaces Inc | Health care | 501(c)(3) | 2005 | $2.8 million | $2.6 million | 2025-12 |
| Tennessee Valley Agricultural & Industrial Fair | Food, agriculture and nutrition | 501(c)(3) | 1943 | $2.8 million | $2.5 million | 2025-12 |
| Susannahs House Inc | Mental health and crisis intervention | 501(c)(3) | 2015 | $2.8 million | $4.8 million | 2026-06 |
| Shades of Development | Human services | 501(c)(3) | 1997 | $2.7 million | $1.6 million | 2025-07 |
| First Choice Community Cu | 501(c)(14) | 1952 | $2.7 million | $48.8 million | 2025-12 | |
| Appalachian Home & Health Inc | Housing and shelter | 501(c)(3) | 2010 | $2.7 million | $4.3 million | 2024-12 |
| Ijams Nature Center Inc | Environment | 501(c)(3) | 1978 | $2.6 million | $4.9 million | 2024-12 |
| United Way of Greater Knoxville Inc | 501(c)(3) | 1960 | $2.5 million | $34.2 million | 2025-06 | |
| East Tennessee Lions Eye Bank | Health care | 501(c)(3) | 1972 | $2.5 million | $4.1 million | 2025-06 |
| FC Alliance Soccer Club | 501(c)(3) | 2020 | $2.5 million | $100,452 | 2025-12 | |
| Paideia Academy | Education | 501(c)(3) | 2004 | $2.4 million | $4.8 million | 2025-06 |
| Metro Drug Coalition Inc | Mental health and crisis intervention | 501(c)(3) | 1987 | $2.4 million | $5.3 million | 2024-09 |
| Freedom in Christ Ministries | Religion-related | 501(c)(3) | 2011 | $2.4 million | $1.4 million | 2025-12 |
| Knoxville Jewish Alliance Inc | Education | 501(c)(3) | 1967 | $2.4 million | $4.1 million | 2025-12 |
| East Tennessee Clean Fuels Coalition | Environment | 501(c)(3) | 2026 | $2.4 million | $1.1 million | 2025-09 |
| United Association of Journeymen & Apprentices of the Plumbing & Pipe | 501(c)(5) | 1941 | $2.3 million | $2.9 million | 2025-06 | |
| Community Coalition Against Human Trafficking | International, foreign affairs and national security | 501(c)(3) | 2013 | $2.3 million | $1.7 million | 2024-12 |
| Matthew 10 International Ministry Inc | Human services | 501(c)(3) | 2006 | $2.3 million | $577,810 | 2024-12 |
| International Union of Operating Engineers Local 917 | 501(c)(5) | 1945 | $2.3 million | $4.1 million | 2025-06 | |
| Alzheimers Tennessee Inc | Diseases, disorders and medical disciplines | 501(c)(3) | 2011 | $2.3 million | $2.1 million | 2025-06 |
| Knoxville Academy of Medicine Foundation | 501(c)(3) | 1989 | $2.2 million | $1.4 million | 2024-12 | |
| Steps House Inc | Mental health and crisis intervention | 501(c)(3) | 1998 | $2.2 million | $6.5 million | 2025-06 |
| Angelic Ministries International Inc | Human services | 501(c)(3) | 2002 | $2.2 million | $2.5 million | 2025-12 |
| Knoxville Christian School | 501(c)(3) | 1970 | $2.2 million | $4.6 million | 2025-06 | |
| Womens Basketball Hall of Fame Inc | Recreation and sports | 501(c)(3) | 1992 | $2.2 million | $5.7 million | 2024-12 |
| Knox County Farm Bureau | 501(c)(5) | 1969 | $2.1 million | $2.3 million | 2026-03 | |
| Ladies of Charity | Community improvement and capacity building | 501(c)(3) | 1973 | $2.1 million | $2.3 million | 2025-12 |
| Big Brothers-Big Sisters of East Tennessee | Youth development | 501(c)(3) | 1975 | $2 million | $1.8 million | 2025-06 |
| Covenant Health Foundation | Health care | 501(c)(3) | 1999 | $2 million | $18.4 million | 2024-12 |
| St Christopher Truckers Development & Relief Fund Inc | Health care | 501(c)(3) | 2008 | $1.9 million | $4.1 million | 2024-12 |
| Cherokee Farm Development Corporation | Education | 501(c)(3) | 2014 | $1.9 million | $3.8 million | 2025-06 |
| Girl Talk Inc | Youth development | 501(c)(3) | 2010 | $1.9 million | $2.8 million | 2025-12 |
| Dogwood Arts Festival Inc | Arts, culture and humanities | 501(c)(3) | 1968 | $1.8 million | $1.4 million | 2025-06 |
| Soar Youth Ministries | Human services | 501(c)(3) | 1998 | $1.8 million | $987,503 | 2025-07 |
| International Brotherhood of Electrical Workers | 501(c)(5) | 1940 | $1.8 million | $4.9 million | 2025-06 | |
| Cerebral Palsy Center for Handicapped Adults Inc | Health care | 501(c)(3) | 2026 | $1.7 million | $524,345 | 2026-06 |
| Muse Knoxville | Arts, culture and humanities | 501(c)(3) | 1969 | $1.7 million | $2.1 million | 2025-06 |
| Knoxville Racquet Club Inc | 501(c)(7) | 1962 | $1.7 million | $1.5 million | 2025-10 | |
| Knoxville Opera Company | Arts, culture and humanities | 501(c)(3) | 1978 | $1.7 million | $1.9 million | 2025-06 |
| A H R M A | 501(c)(4) | 1991 | $1.6 million | $372,179 | 2025-11 | |
| Knoxville Montessori School | Education | 501(c)(3) | 1966 | $1.6 million | $2.6 million | 2025-06 |
| Tennessee Aquatics Inc | Recreation and sports | 501(c)(3) | 1995 | $1.5 million | $526,450 | 2025-08 |
| Knoxville Area Urban League | Human services | 501(c)(3) | 1968 | $1.5 million | $8.2 million | 2025-06 |
| International Association of Fire Fighters | 501(c)(5) | 1966 | $1.5 million | $381,996 | 2025-12 | |
| River and Rail Theatre Company | Arts, culture and humanities | 501(c)(3) | 2015 | $1.5 million | $2.3 million | 2025-06 |
| Little Oaks Academy | Human services | 501(c)(3) | 2015 | $1.5 million | $771,664 | 2025-06 |
| Make A Wish Foundation of East Tennessee Inc | Health care | 501(c)(3) | 1988 | $1.5 million | $1.1 million | 2024-08 |
| Humane Society of the Tennessee Valley Inc | Animal-related | 501(c)(3) | 1983 | $1.5 million | $2.8 million | 2025-06 |
| International Association of Bridge Structural & Ornamental Iron Worke | 501(c)(5) | 1944 | $1.4 million | $2.7 million | 2025-06 | |
| Childrens Center of Knoxville Inc | Human services | 501(c)(3) | 1977 | $1.4 million | $1.1 million | 2025-06 |
| Builders Exchange of Tennessee Inc | 501(c)(6) | 1950 | $1.4 million | $2.8 million | 2024-12 | |
| Sheet Metal Workers Local Union 5 Joint Apprenticeship Training | 501(c)(5) | 1987 | $1.4 million | $2 million | 2025-12 | |
| Concensio Collective Inc | Education | 501(c)(3) | 2015 | $1.4 million | $747,097 | 2024-12 |
| Leadership Knoxville Inc | Education | 501(c)(3) | 1985 | $1.4 million | $2.8 million | 2025-06 |
| East Tennessee Economic Development Agency Inc | Education | 501(c)(3) | 1986 | $1.4 million | $5.6 million | 2025-09 |
| Global Infusion Inc | International, foreign affairs and national security | 501(c)(3) | 2003 | $1.4 million | $445,948 | 2024-12 |
| Knoxville Cbid Management Corporation | Community improvement and capacity building | 501(c)(3) | 1995 | $1.4 million | $2.1 million | 2025-06 |
| Alpha Delta Pi House Corp Alpha Kappa | 501(c)(7) | 1968 | $1.4 million | $2.4 million | 2025-06 | |
| E M Jellinek Center Inc | 501(c)(3) | 1974 | $1.3 million | $1.5 million | 2025-06 | |
| East Tennessee Housing Development Corporation | Housing and shelter | 501(c)(3) | 1994 | $1.3 million | $1.5 million | 2025-06 |
| Free Medical Clinic of America | Health care | 501(c)(3) | 2006 | $1.3 million | $2.2 million | 2025-06 |
| Plumbers & Steamfitters Joint Apprenticeship Training Committee | 501(c)(5) | 1971 | $1.3 million | $7.6 million | 2025-06 | |
| Neighborhood Housing Inc | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 1999 | $1.3 million | $437,198 | 2025-12 |
| Sacred Ground Hospice House | Health care | 501(c)(3) | 2019 | $1.3 million | $2.7 million | 2024-12 |
| William S & MRS W S Hughes Johnson Bible College Perpetual Trust Fund | 501(c)(91) | $1.2 million | $8.1 million | 2025-12 | ||
| Ronald McDonald House Charities of Knoxville Tennessee Inc | Health care | 501(c)(3) | 1983 | $1.2 million | $14.7 million | 2025-12 |
| Knoxville Center of the Deaf Inc | 501(c)(3) | 1977 | $1.2 million | $1.2 million | 2024-12 | |
| East Tennessee Historical Society Inc | Arts, culture and humanities | 501(c)(3) | 2010 | $1.2 million | $4.3 million | 2024-12 |
| Missio International | 501(c)(3) | 1996 | $1.2 million | $722,032 | 2025-12 | |
| West High School Athletic Council Inc | Education | 501(c)(3) | 2017 | $1.1 million | $406,923 | 2025-06 |
| Wesley House Community Center | Housing and shelter | 501(c)(3) | 1978 | $1.1 million | $3.4 million | 2025-07 |
| Better Business Bureau of Greater Knoxville Inc | 501(c)(6) | 1961 | $1.1 million | $2.4 million | 2025-09 | |
| Olive Tree Early Learning Academy | Human services | 501(c)(3) | 2023 | $1.1 million | $2.2 million | 2025-12 |
| The First Tee of Greater Knoxville | Recreation and sports | 501(c)(3) | 2001 | $1.1 million | $4 million | 2024-12 |
| North America Outdoors Inc | 501(c)(6) | 1983 | $1.1 million | $669,662 | 2025-12 | |
| Tennessee Kappa Chapter of Sigma Alpha Epsilon | 501(c)(7) | 2019 | $1.1 million | $71,810 | 2025-06 | |
| Conservation Fisheries Inc | Environment | 501(c)(3) | 1993 | $1.1 million | $1.1 million | 2025-09 |
| Knoxville College | Education | 501(c)(3) | 1944 | $1.1 million | $3.1 million | 2024-06 |
| Knoxville Botanical Gardens and Arboretum | Environment | 501(c)(3) | 2002 | $1 million | $3 million | 2024-12 |
| Knoxville Bar Association Inc | 501(c)(6) | 1981 | $1 million | $456,691 | 2025-12 | |
| Beck Cultural Exchange Center Inc | Arts, culture and humanities | 501(c)(3) | 1975 | $1 million | $3.8 million | 2025-06 |
| Volunteer Legacy Inc | Recreation and sports | 501(c)(3) | 2022 | $1 million | $219,536 | 2025-06 |
| Agape Outreach Home Inc | Human services | 501(c)(3) | 1985 | $1 million | $407,924 | 2025-03 |
| Tennessee Memory Disorders Foundation | Mental health and crisis intervention | 501(c)(3) | 2021 | $1 million | $455,443 | 2024-12 |
| Hope Resource Center | Health care | 501(c)(3) | 1985 | $1 million | $937,240 | 2025-06 |
| Fig Solutions | Housing and shelter | 501(c)(3) | 2020 | $1 million | $8 million | 2025-09 |
| Gap Connections Inc | Food, agriculture and nutrition | 501(c)(3) | 2024 | $999,363 | $715,204 | 2024-12 |
| Knoxville Entrepreneur Center | Education | 501(c)(3) | 2014 | $991,337 | $449,178 | 2025-06 |
| Pi Chapter Chi Omega Fraternity House Corp | 501(c)(7) | 1990 | $988,660 | $1 million | 2025-06 | |
| Southeastern Housing Foundation II | Housing and shelter | 501(c)(3) | 2010 | $978,134 | $14.3 million | 2025-12 |
| Seeed Inc | Community improvement and capacity building | 501(c)(3) | 2014 | $963,942 | $368,585 | 2025-12 |
| Cumberland Communities Communications Corporation | 501(c)(3) | 1992 | $962,976 | $708,329 | 2024-12 | |
| Three3 Inc | Education | 501(c)(3) | 2014 | $956,892 | $115,656 | 2024-12 |
| Community Shares Inc | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 1985 | $933,235 | $971,692 | 2025-06 |
| Alpha Epsilon House Corporation of Kappa Delta Sorority | Education | 501(c)(7) | 2014 | $926,562 | $5.6 million | 2025-06 |
| Road Runners Club of America | Recreation and sports | 501(c)(3) | 1976 | $923,633 | $511,469 | 2023-12 |
| Laborers International Union of North America | 501(c)(5) | 1944 | $917,598 | $2.1 million | 2025-06 | |
| Kappa Delta Sorority | 501(c)(7) | 1941 | $912,692 | $526,716 | 2025-06 | |
| International Association of Heat & Frost Insulators & Allied Workers | 501(c)(5) | 1967 | $909,996 | $2 million | 2025-05 | |
| Knoxville Symphony Foundation | Arts, culture and humanities | 501(c)(3) | 2002 | $903,963 | $13.8 million | 2025-05 |
| Prevention Alliance of Tennessee | Health care | 501(c)(3) | 2021 | $903,487 | $404,245 | 2025-06 |
| World Water Project | Religion-related | 501(c)(3) | 2011 | $897,190 | $101,834 | 2024-12 |
| Christ for You | Religion-related | 501(c)(3) | 2012 | $888,313 | $177,717 | 2025-12 |
| Joy of Music Youth Music School Corporation | Arts, culture and humanities | 501(c)(3) | 2001 | $877,779 | $5.6 million | 2025-06 |
| Community Television of Knoxville | Arts, culture and humanities | 501(c)(3) | 1986 | $873,698 | $1.3 million | 2024-06 |
| The Cancer Support Community East Tennessee | 501(c)(3) | 1989 | $869,244 | $5.7 million | 2024-12 | |
| Sheet Metal Workers Union Training Fund of NC | 501(c)(5) | 1977 | $868,854 | $1.7 million | 2025-12 | |
| Second Chance Global | Human services | 501(c)(3) | 2016 | $867,513 | $493,071 | 2025-06 |
| Trinity Health Foundation of East Tennessee | Health care | 501(c)(3) | 2012 | $855,868 | $32.6 million | 2024-12 |
| U T Hospital Auxiliary Gift Shop Fund | Health care | 501(c)(3) | 1972 | $853,348 | $1.1 million | 2024-12 |
| Statewide Organizing for Community Empowerment Resource Project | Environment | 501(c)(3) | 1984 | $844,141 | $541,691 | 2024-12 |
| Thompson Cancer Survival Foundation | Diseases, disorders and medical disciplines | 501(c)(3) | 1994 | $840,184 | $5 million | 2024-12 |
| Historic Tennessee Theatre Endowment Fund | Arts, culture and humanities | 501(c)(3) | 2009 | $826,672 | $12.6 million | 2025-12 |
| District Council of Knoxville Society of St Vincent de Paul | Human services | 501(c)(3) | 2019 | $822,850 | $392,432 | 2025-09 |
| Mental Health Association of East Tennessee Inc | Mental health and crisis intervention | 501(c)(3) | 1956 | $822,470 | $616,253 | 2025-06 |
| Tayseer Foundation | Religion-related | 501(c)(3) | 2013 | $815,015 | $3.8 million | 2024-12 |
| Knoxville Museum of Art Foundation | Arts, culture and humanities | 501(c)(3) | 1998 | $813,635 | $11.6 million | 2025-06 |
| Healthcaretn | Medical research | 501(c)(3) | 1998 | $803,631 | $1.9 million | 2024-12 |
| E3 School Support Inc | Education | 501(c)(3) | 2019 | $803,500 | $954,584 | 2025-12 |
| American Friends of Ruach Tova Inc | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 2009 | $800,118 | $26,291 | 2024-12 |
| Tennessee Valley Coalition To End Homelessness Inc | Human services | 501(c)(3) | 2008 | $794,082 | $207,756 | 2025-09 |
| Knoxville Childrens Theatre Inc | Arts, culture and humanities | 501(c)(3) | 2014 | $792,740 | $643,069 | 2024-12 |
| 4TH Purpose Foundation | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 2020 | $779,843 | $12.8 million | 2024-12 |
| Electrician Training Academy at Knoxville | Education | 501(c)(3) | 1971 | $770,797 | $826,105 | 2024-12 |
| M R Lovette Tuwc-McKinney Cem | 501(c)(91) | $763,790 | $6.6 million | 2025-12 | ||
| Knox Youth Sports Inc | Recreation and sports | 501(c)(3) | 1987 | $763,176 | $683,932 | 2025-06 |
| East Tennessee Community Design Center Inc | Community improvement and capacity building | 501(c)(3) | 1972 | $761,814 | $1.3 million | 2024-12 |
| Disability Resource Center Inc | Human services | 501(c)(3) | 1995 | $736,144 | $416,126 | 2025-06 |
| Nourish Knoxville | Food, agriculture and nutrition | 501(c)(3) | 2014 | $735,758 | $566,909 | 2024-12 |
| Knoxville Family Justice Center | Human services | 501(c)(3) | 2006 | $734,545 | $447,339 | 2025-06 |
| Epsilon Eta Chapter of Sigma Nu Fraternity | Recreation and sports | 501(c)(7) | 2019 | $723,286 | $17,306 | 2025-12 |
| Fort Loudoun Yacht Club Inc | 501(c)(7) | 1961 | $718,728 | $1.9 million | 2025-09 | |
| Hellbender Harm Reduction | Health care | 501(c)(3) | 2023 | $709,498 | $70,832 | 2025-12 |
| Knoxville Inner City Kids Outreach | Youth development | 501(c)(3) | 1996 | $701,627 | $939,308 | 2024-12 |
| Knoxville Jewish Community Family of Funds | Arts, culture and humanities | 501(c)(3) | 2000 | $699,159 | $5.7 million | 2024-12 |
| Knox County Employees Credit Union | Public and societal benefit | 501(c)(14) | 1952 | $696,477 | $13 million | 2025-12 |
| Chapman Learning Center Inc New Corp | Human services | 501(c)(3) | 1999 | $696,327 | $672,130 | 2024-12 |
| Davis Center for Child Development Inc | Human services | 501(c)(3) | 2014 | $684,694 | $67,712 | 2024-12 |
| Home Builders Association of Greater Knoxville | 501(c)(6) | 1967 | $669,032 | $977,531 | 2024-12 | |
| Knoxville Christian Community Foundation | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 1998 | $664,674 | $312,687 | 2025-12 |
| Sertoma Centers My Life Foundation Inc | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 1999 | $658,968 | $4.6 million | 2025-06 |
| Engineering Association Inc | 501(c)(5) | 1941 | $651,894 | $1.2 million | 2024-12 | |
| Peer Academy | Education | 501(c)(3) | 2017 | $651,655 | $2.3 million | 2025-09 |
| Knox County Other Post-Employment Disability Benefits Trust | Mutual and membership benefit | 501(c)(9) | 2023 | $645,219 | $2 million | 2021-06 |
| Renew Clinic | Mental health and crisis intervention | 501(c)(3) | 2019 | $641,342 | $271,186 | 2025-12 |
| New Direction Health Care Solutions | Health care | 501(c)(3) | 2021 | $639,262 | $206,729 | 2025-12 |
| Society for the Study of Social Problems | Social science | 501(c)(3) | 1973 | $634,685 | $1.1 million | 2025-12 |
| The Development Corporation of Knox County Tennessee | Community improvement and capacity building | 501(c)(3) | 1990 | $632,758 | $42.5 million | 2023-06 |
| Friends of the Knox County Public Library | 501(c)(3) | 1977 | $625,784 | $1.4 million | 2026-06 | |
| National Association To Protect Children-Education Fund Inc | Public safety, disaster preparedness and relief | 501(c)(3) | 2005 | $620,900 | $907,308 | 2025-09 |
| Yoke Youth Ministries | Religion-related | 501(c)(3) | 1979 | $602,049 | $197,198 | 2024-12 |
| Adopt A Golden Knoxville Inc | Animal-related | 501(c)(3) | 2011 | $598,648 | $729,786 | 2025-12 |
| The Dr Robert F Thomas Foundation Inc | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 2023 | $582,343 | $7.8 million | 2024-12 |
| The Love Kitchen Incorporated | Food, agriculture and nutrition | 501(c)(3) | 2020 | $577,666 | $1.4 million | 2025-12 |
| Cherokee Country Club Foundation | Public safety, disaster preparedness and relief | 501(c)(3) | 2023 | $571,333 | $884,582 | 2024-12 |
| Delta Sigma House Corporation of Delta Delta Delta | 501(c)(7) | 1964 | $566,345 | $5 million | 2025-06 | |
| National Association of Blind Merchants | Human services | 501(c)(3) | 2014 | $549,053 | $400,766 | 2024-12 |
| Associated General Contractors of Tennessee Inc-Knoxville | 501(c)(6) | 1977 | $547,312 | $1.3 million | 2024-12 | |
| Reap International Inc | Religion-related | 501(c)(3) | 1998 | $544,346 | $690,947 | 2025-12 |
| 4 Market Square | Religion-related | 501(c)(3) | 2001 | $541,701 | $7.6 million | 2025-06 |
| Fraternal Order of Police | Crime and legal-related | 501(c)(8) | 1952 | $538,128 | $1 million | 2025-12 |
| Trees Knoxville | Environment | 501(c)(3) | 2017 | $533,475 | $144,060 | 2025-12 |
| Turn Up Knox | Crime and legal-related | 501(c)(3) | 2024 | $533,151 | $177,290 | 2024-12 |
| Variety of Eastern Tennessee | Youth development | 501(c)(3) | 2003 | $526,644 | $1 million | 2025-09 |
| Construction Labor Research Council | 501(c)(6) | $523,905 | $852,420 | 2024-12 | ||
| Knoxville Amateur Hockey Association | 501(c)(3) | 1978 | $523,412 | $133,091 | 2025-03 | |
| Knoxville Iron Workers Local 384 Joint Apprenticeship Committee Tru | 501(c)(5) | 1988 | $515,507 | $693,737 | 2025-06 | |
| Hope Well Foundation | Mental health and crisis intervention | 501(c)(3) | 2022 | $512,332 | $654,284 | 2025-12 |
| The National Information Officers Association Incorporated | 501(c)(3) | 1990 | $505,898 | $272,513 | 2025-12 | |
| Asian Culture Center of Tennessee | Arts, culture and humanities | 501(c)(3) | 2015 | $505,044 | $400,061 | 2025-12 |
| Methodist Medical Center Foundation | Health care | 501(c)(3) | 1990 | $503,123 | $2.1 million | 2024-12 |
| Knox Heritage Inc | 501(c)(3) | 1977 | $501,671 | $3.3 million | 2025-12 | |
| Future Forward Inc | Human services | 501(c)(3) | 2024 | $496,752 | $319,342 | 2025-12 |
| Claws and Paws for A Cause | Religion-related | 501(c)(3) | 2014 | $491,073 | $0 | 2024-12 |
| Educator Resource Center | Community improvement and capacity building | 501(c)(3) | 2025 | $490,166 | $239,253 | 2025-12 |
| Community Reuse Organization of East Tennessee | Community improvement and capacity building | 501(c)(3) | 1997 | $486,897 | $6.4 million | 2025-09 |
| The Bottom | Arts, culture and humanities | 501(c)(3) | 2021 | $486,264 | $386,812 | 2024-12 |
| Infusion Ministries | Religion-related | 501(c)(3) | 2008 | $480,548 | $29,970 | 2025-12 |
| National Rural Letter Carriers Association | 501(c)(5) | 1972 | $477,058 | $619,059 | 2025-06 | |
| Renaissance Creations | Community improvement and capacity building | 501(c)(3) | 2019 | $470,144 | $503,852 | 2024-12 |
| Hand Up for Women | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 2002 | $469,073 | $633,398 | 2024-12 |
| E3 Elevating Education Everywhere Inc | Religion-related | 501(c)(3) | 2014 | $467,540 | $434,947 | 2025-12 |
| Raising A Voice | International, foreign affairs and national security | 501(c)(3) | 2018 | $466,714 | $1 million | 2024-12 |
| Tennessee Solar Energy Industries Association Inc | Community improvement and capacity building | 501(c)(6) | 2010 | $465,066 | $295,345 | 2025-12 |
| Carecuts Inc | Human services | 501(c)(3) | 2016 | $464,984 | $495,560 | 2025-12 |
| American Women Artists | Arts, culture and humanities | 501(c)(3) | 1998 | $464,067 | $422,953 | 2025-06 |
| Jesus Centered Ministries Inc | Religion-related | 501(c)(3) | 1995 | $463,360 | $180,088 | 2024-12 |
| One Vision International Inc | Religion-related | 501(c)(3) | 2006 | $456,368 | $66,983 | 2024-12 |
| Chi Omega Fraternity | 501(c)(7) | 1940 | $455,776 | $25,693 | 2026-06 | |
| Tennessee Valley Golden Retriever Rescue | Animal-related | 501(c)(3) | 2000 | $453,246 | $369,996 | 2025-12 |
| Keep the Tennessee River Beautiful | Environment | 501(c)(3) | 2018 | $453,131 | $255,789 | 2024-06 |
| Kids Place at Sequoyah Inc | Education | 501(c)(3) | 1996 | $442,276 | $185,683 | 2025-06 |
| Womens Fund of East Tenenssee | Human services | 501(c)(3) | 2015 | $439,271 | $233,566 | 2024-12 |
| Tristar Rowing | Recreation and sports | 501(c)(3) | 2019 | $438,564 | $173,217 | 2025-05 |
| PPS & Focus Group Ministries Inc | Religion-related | 501(c)(3) | 1999 | $438,160 | $515,898 | 2024-12 |
| Deeper Still | Religion-related | 501(c)(3) | 2003 | $438,120 | $195,900 | 2024-12 |
| A Step Ahead Foundation of East Tennessee Inc | Health care | 501(c)(3) | 2016 | $438,050 | $173,498 | 2025-06 |
| Mountain Valley Economic Opportunity Authority | Community improvement and capacity building | 501(c)(3) | 1975 | $431,765 | $206,872 | 2025-06 |
| Community Organization Networking Neighborhoods Encouraging Change | Human services | 501(c)(3) | 2009 | $431,591 | $534,228 | 2025-12 |
| Lambda Chi Alpha Fraternity Inc | 501(c)(7) | 1941 | $429,100 | $12,215 | 2024-06 | |
| Farragut Chamber of Commerce | 501(c)(6) | 1989 | $426,919 | $236,947 | 2025-06 | |
| Knoxville Dream Center Inc | Housing and shelter | 501(c)(3) | 2014 | $424,567 | $163,693 | 2025-12 |
| Shora Foundation | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 2008 | $421,459 | $41,347 | 2025-12 |
| Knox Haven | Human services | 501(c)(3) | 2023 | $419,259 | $141,075 | 2024-12 |
| National Embryo Adoption Center | Health care | 501(c)(3) | 2006 | $419,229 | $458,279 | 2025-06 |
| Rotary Zones 30 & 31 Inc | Mutual and membership benefit | 501(c)(3) | 2019 | $417,341 | $314,244 | 2025-06 |
| Orthopaedic Innovation Technology Center Inc | Medical research | 501(c)(3) | 2022 | $416,250 | $394,603 | 2025-12 |
| Camp Koinonia Foundation Inc | Human services | 501(c)(3) | 2002 | $414,086 | $1.8 million | 2025-06 |
| Keep Knoxville Beautiful Inc | Environment | 501(c)(3) | 1980 | $412,096 | $413,995 | 2025-06 |
| Community Mediation Center Inc | Civil rights, social action and advocacy | 501(c)(3) | 1995 | $411,118 | $178,092 | 2025-06 |
| Random Acts of Flowers | Health care | 501(c)(3) | 2009 | $409,065 | $481,591 | 2025-12 |
| Knox County Community Gardens and Growers Alliance | Food, agriculture and nutrition | 501(c)(3) | 2022 | $408,376 | $451,935 | 2024-12 |
| Pi Kappa Alpha Fraternity | Education | 501(c)(7) | 1941 | $407,628 | $3,986 | 2025-06 |
| Kappa Sigma Fraternity | 501(c)(7) | 1940 | $405,433 | $45,099 | 2025-05 | |
| Tennessee Christian Teen Convention | Religion-related | 501(c)(3) | 2000 | $398,954 | $71,480 | 2026-02 |
| Next Step Initiative Tennessee | Housing and shelter | 501(c)(3) | 2022 | $397,545 | $67,291 | 2025-06 |
| Lost Sheep Ministries Inc | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 1998 | $394,713 | $645,329 | 2025-12 |
| Chesterton Academy of Saint Margaret Clitherow | Education | 501(c)(3) | 2023 | $391,881 | $178,931 | 2025-06 |
| Widowed Parent Relief Project | Human services | 501(c)(3) | 2022 | $387,388 | $527,451 | 2025-12 |
| First Step II Inc | 501(c)(3) | 1993 | $385,019 | $764,571 | 2025-12 | |
| Homes of Love Inc | Housing and shelter | 501(c)(3) | 2002 | $382,447 | $315,372 | 2025-06 |
| Burger Family Foundation Inc | Human services | 501(c)(3) | 2025 | $382,268 | $325,557 | 2025-12 |
| Partners for Children | Education | 501(c)(3) | 1989 | $381,606 | $412,864 | 2024-12 |
| Forever Families Inc | Religion-related | 501(c)(3) | 1999 | $381,045 | $751,187 | 2025-12 |
| Operation Inasmuch Incorporated | Religion-related | 501(c)(3) | 2005 | $380,936 | $572,837 | 2024-12 |
| East Tennessee Equality Council Inc | Civil rights, social action and advocacy | 501(c)(3) | 2014 | $380,087 | $36,455 | 2025-12 |
| Tennessee Advanced Energy Business Council | Environment | 501(c)(3) | 2014 | $378,450 | $78,918 | 2024-12 |
| Knoxville Jazz Orchestra | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 2001 | $377,086 | $285,513 | 2026-06 |
| The Change Center | Youth development | 501(c)(3) | 2016 | $374,410 | $3.5 million | 2025-12 |
| The Cedar Bluff Farragut Optimist Youth Activities Organization Inc | Recreation and sports | 501(c)(3) | 1997 | $360,338 | $255,137 | 2025-09 |
| Conduc Inc | Diseases, disorders and medical disciplines | 501(c)(3) | 2023 | $357,810 | $161,689 | 2024-12 |
| West End Christian School | Education | 501(c)(3) | 1988 | $354,882 | $389,311 | 2025-06 |
| Tennessee Press Association | 501(c)(6) | 1949 | $352,399 | $130,410 | 2024-11 | |
| Family Promise of Knoxville | Housing and shelter | 501(c)(3) | 2004 | $349,354 | $987,584 | 2024-12 |
| Blue Grass Elementary Pto | Education | 501(c)(3) | 2015 | $348,081 | $289,609 | 2026-06 |
| Hope Redefined | Religion-related | 501(c)(3) | 2018 | $345,185 | $79,609 | 2024-12 |
| International Association of Sheet Metal Air Rail & Transportation | Employment | 501(c)(5) | 2015 | $344,309 | $145,019 | 2025-12 |
| Two Bikes | Education | 501(c)(3) | 2022 | $343,964 | $101,031 | 2025-12 |
| Southern Alliance for Clean Energy Sace | 501(c)(4) | 1981 | $343,599 | $2.3 million | 2025-12 | |
| Seeds & Bridges Inc | Public safety, disaster preparedness and relief | 501(c)(3) | 2024 | $342,469 | $416,229 | 2025-12 |
| Hope Springs Adult Day Care Center Inc | Human services | 501(c)(3) | 2019 | $337,357 | $85,627 | 2025-12 |
| Christ Is the Answer Ministries | International, foreign affairs and national security | 501(c)(3) | 2014 | $335,295 | $31,908 | 2024-12 |
| Farragut Baseball Inc | Recreation and sports | 501(c)(3) | 1996 | $331,967 | $2,517 | 2024-12 |
| Knox Makers | Education | 501(c)(3) | 2014 | $324,161 | $447,529 | 2025-12 |
| Knoxville History Project | Arts, culture and humanities | 501(c)(3) | 2015 | $323,431 | $489,035 | 2025-12 |
| Jireh Homeschool Cooperative | Education | 501(c)(3) | 2024 | $319,360 | $91,851 | 2026-06 |
| Family Investment Foundation Inc | Human services | 501(c)(3) | 2004 | $315,640 | $718,549 | 2025-06 |
| Knoxville Academy of Medicine | 501(c)(6) | 1966 | $312,172 | $1.3 million | 2024-12 | |
| Fountain City Recreation Commission Inc | Recreation and sports | 501(c)(3) | 2013 | $310,794 | $365,357 | 2025-12 |
| Arc Foundation Inc | International, foreign affairs and national security | 501(c)(3) | 2022 | $307,500 | $55,796 | 2025-12 |
| Concord Yacht Club Inc | 501(c)(7) | 1969 | $304,413 | $978,592 | 2025-12 | |
| The@mend House Sobor Living Community for Men | Mental health and crisis intervention | 501(c)(3) | 2020 | $303,690 | $0 | 2024-12 |
| Morristown-Hamblen Hospital | Health care | 501(c)(3) | 1998 | $300,197 | $2 million | 2024-12 |
| East Tennessee Supporting Foundation | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 1996 | $299,263 | $11.1 million | 2024-12 |
| Inner Path Center Inc | Religion-related | 501(c)(3) | 2014 | $296,303 | $523,501 | 2024-12 |
| Lasting Impressions Wilderness Training Corporation | International, foreign affairs and national security | 501(c)(3) | 2002 | $294,064 | $145,352 | 2025-12 |
| Provision Trust Inc | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 2019 | $292,196 | $64,217 | 2025-12 |
| College Athletic Trainers Society | Education | 501(c)(6) | 2003 | $291,405 | $695,516 | 2025-12 |
| Tennessee State Society of Anesthesiologists | Community improvement and capacity building | 501(c)(6) | 2017 | $290,401 | $513,406 | 2025-12 |
| Rotary International | 501(c)(4) | 1958 | $289,628 | $220,627 | 2025-06 | |
| Adolescent and Young Adult Cancer Alliance | Medical research | 501(c)(3) | 2022 | $287,605 | $74,359 | 2025-12 |
| Knox County Rescue | 501(c)(3) | 1960 | $286,755 | $1.1 million | 2025-06 | |
| Village Green Homeowners Association Inc | Community improvement and capacity building | 501(c)(4) | 2003 | $286,458 | $363,010 | 2024-12 |
| Governor William Blount Mansion Association | 501(c)(3) | 1956 | $285,470 | $1.2 million | 2025-06 | |
| Knox Forest School | Education | 501(c)(3) | 2021 | $284,687 | $5,240 | 2024-12 |
| Phi Kappa Psi Fraternity Tennessee Epsilon Chapter | 501(c)(7) | 2023 | $282,310 | $9,603 | 2025-05 | |
| Ancient & Accepted Scottish Rite of Free Masonry So Juris USA | 501(c)(10) | 1940 | $281,902 | $3.2 million | 2025-12 | |
| Peninsula Club Incorporated | 501(c)(7) | 1971 | $280,763 | $496,173 | 2025-10 | |
| Giving Tree Montessori | Education | 501(c)(3) | 1980 | $276,672 | $32,982 | 2025-12 |
| Phi Gamma Delta Fraternity | 501(c)(7) | 1940 | $273,653 | $2,243 | 2025-06 | |
| American Research Universities - Human Resource Institute | Education | 501(c)(3) | 2019 | $270,369 | $368,324 | 2025-06 |
| Edgewood Cemetery | Mutual and membership benefit | 501(c)(13) | 2008 | $268,739 | $870,875 | 2024-12 |
| Knox County Education Association | 501(c)(5) | 1981 | $267,258 | $917,805 | 2025-06 | |
| Community School of the Arts | Arts, culture and humanities | 501(c)(3) | 1992 | $265,611 | $256,898 | 2025-06 |
| Communication Workers of America | 501(c)(5) | 1953 | $264,909 | $812,100 | 2025-09 | |
| Alpha Gamma Delta Fraternity | Education | 501(c)(7) | 1941 | $263,785 | $34,042 | 2025-06 |
| Global Golf | Religion-related | 501(c)(3) | 2012 | $263,011 | $455,915 | 2024-12 |
| Water Angel Ministries Inc | Human services | 501(c)(3) | 2003 | $260,881 | $138,594 | 2024-12 |
| Never Alone Transitional | Mental health and crisis intervention | 501(c)(3) | 2020 | $260,415 | $46,607 | 2025-12 |
| PJ Parkinsons Support Group of Blount County | Diseases, disorders and medical disciplines | 501(c)(3) | 2015 | $258,224 | $277,001 | 2025-12 |
| Epperson Ministries | Mental health and crisis intervention | 501(c)(3) | 2019 | $258,093 | $5,858 | 2024-12 |
| International Medical Alliance of Tennessee | Human services | 501(c)(3) | 2008 | $257,861 | $110,929 | 2024-12 |
| Smoky Mountain Lions Charities Inc | 501(c)(3) | 2005 | $256,519 | $319,073 | 2025-06 | |
| Fallen Vol Foundation Inc | Recreation and sports | 501(c)(3) | 2024 | $256,000 | $257,025 | 2025-12 |
| Kerbela Shriners | 501(c)(10) | 1940 | $254,916 | $2.1 million | 2025-12 | |
| Fostering Hope TN Inc | Human services | 501(c)(3) | 2017 | $253,464 | $72,335 | 2025-12 |
| Casa of East Tennessee Inc | 501(c)(3) | 1987 | $253,259 | $322,991 | 2025-06 | |
| Techlaw Group Inc | 501(c)(6) | 1990 | $251,265 | $457,008 | 2025-12 | |
| Epilepsy Foundation of East Tennessee | Diseases, disorders and medical disciplines | 501(c)(3) | 1978 | $250,647 | $175,733 | 2025-06 |
| Kidtime Inc | Human services | 501(c)(3) | 1998 | $250,421 | $351,948 | 2025-12 |
| Hillcrest Healthcare Foundation | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 2005 | $250,326 | $1.6 million | 2025-06 |
| Friends of Literacy Inc | Education | 501(c)(3) | 1992 | $250,215 | $115,046 | 2025-12 |
| Tarlov Cyst Disease Foundation | Medical research | 501(c)(3) | 2007 | $249,987 | $3.1 million | 2025-12 |
| Project Help of East Tennessee Inc | Human services | 501(c)(3) | 2010 | $248,917 | $611,524 | 2025-12 |
| Georgia Chamber of Commerce Executives Assoc | 501(c)(6) | 1987 | $247,978 | $311,060 | 2025-06 | |
| Feral Feline Friends of East Tennessee | Animal-related | 501(c)(3) | 2009 | $242,094 | $37,473 | 2025-12 |
| Community Action for Affordable Neighborhoods | Housing and shelter | 501(c)(3) | 2010 | $239,652 | $213,488 | 2025-06 |
| Collegiate Abbey Inc | Religion-related | 501(c)(3) | 2016 | $237,497 | $14,443 | 2025-12 |
| No Athlete Left Behind Foundation Inc | Recreation and sports | 501(c)(3) | 2022 | $237,161 | $17,156 | 2025-12 |
| Fidelis Sisterhood | Religion-related | 501(c)(3) | 2019 | $236,860 | $130,999 | 2025-09 |
| Rocky Hill Elementary School Foundation | Education | 501(c)(3) | 2012 | $233,406 | $119,605 | 2026-06 |
| Word Players | 501(c)(3) | 1998 | $229,549 | $77,304 | 2025-07 | |
| Kosher Torah School Inc | Religion-related | 501(c)(3) | 2025 | $228,682 | $4,472 | 2025-12 |
| Cross Greek Christian Ministries Inc | Religion-related | 501(c)(3) | 2001 | $228,415 | $61,422 | 2025-06 |
| Foothills Resource Group | Arts, culture and humanities | 501(c)(3) | 1993 | $225,329 | $960,660 | 2024-12 |
| Dragonfly Aerial and Circus Arts Studio | Arts, culture and humanities | 501(c)(3) | 2014 | $224,318 | $100,394 | 2025-06 |
| Beta Sigma of Sigma Chi House Corporation | 501(c)(7) | 1994 | $223,775 | $1.3 million | 2025-06 | |
| Christian Hospitality Network Inc | Religion-related | 501(c)(3) | 2021 | $222,083 | $100,644 | 2026-06 |
| Nation Utility Contractors Association Inc | Community improvement and capacity building | 501(c)(6) | 2010 | $219,596 | $135,255 | 2024-12 |
| With Inc | Religion-related | 501(c)(3) | 2015 | $219,553 | $38,373 | 2025-12 |
| Jefferson County Festival Charities | Arts, culture and humanities | 501(c)(3) | 2020 | $219,131 | $52,597 | 2023-12 |
| Johnson Bible College Teachers Trust | 501(c)(91) | $218,975 | $1.4 million | 2025-12 | ||
| Gamma Beta Phi Society | 501(c)(3) | 1966 | $216,976 | $16,769 | 2025-06 | |
| Eternal Vision Ministries Inc | Religion-related | 501(c)(3) | 1996 | $215,491 | $5,021 | 2025-12 |
| Tennessee Mining Association A Tenn Non-Profit Mutual BNFT Corp | Community improvement and capacity building | 501(c)(6) | 2011 | $214,750 | $51,359 | 2024-12 |
| Anchor Learning Center | Religion-related | 501(c)(3) | 2024 | $214,359 | $172,993 | 2026-06 |
| Focus Congo USA | International, foreign affairs and national security | 501(c)(3) | 2024 | $213,290 | $224,835 | 2025-12 |
| Resource Valley Construction Training Council Inc | 501(c)(6) | 1992 | $212,950 | $264,821 | 2025-06 | |
| Greater Things | Religion-related | 501(c)(3) | 2015 | $211,442 | $514,716 | 2025-12 |
| Tennessee Society of Allergy Asthma and Immunology | Diseases, disorders and medical disciplines | 501(c)(6) | 2001 | $210,903 | $310,249 | 2025-12 |
| James Whites Fort Association Inc | Arts, culture and humanities | 501(c)(3) | 1969 | $210,761 | $587,820 | 2024-12 |
| Eternal Lifes Restoration Outreach | Religion-related | 501(c)(3) | 1989 | $210,699 | $2.2 million | 2024-12 |
| Knoxville News-Sentinel Charities Inc | Human services | 501(c)(3) | 1975 | $210,433 | $565,153 | 2025-12 |
| Ralph E Madden Trust B Uw | 501(c)(91) | $209,253 | $1.6 million | 2025-12 | ||
| Message of Life Ministries | Religion-related | 501(c)(3) | 2006 | $205,805 | $798,806 | 2025-12 |
| Lake Erie Sports Alliance | Recreation and sports | 501(c)(3) | 2023 | $204,168 | $73,283 | 2024-12 |
| National Association of Letter Carriers | Employment | 501(c)(5) | 1944 | $203,856 | $181,961 | 2025-12 |
| International Brotherhood of Teamsters | 501(c)(5) | 1963 | $198,839 | $867,723 | 2025-12 | |
| Tennessee Association of Plumbing-Heating-Cooling Contracto | 501(c)(6) | 1961 | $198,626 | $212,939 | 2025-06 | |
| Hardin Valley Academy Athletic Council | Education | 501(c)(3) | 2009 | $198,416 | $145,099 | 2025-06 |
| Loyal Order of the Moose 1560 | Mutual and membership benefit | 501(c)(8) | 2024 | $198,125 | $526,033 | 2026-04 |
| Knoxville Rotary Club Student Loan Fund Inc | Education | 501(c)(3) | 1942 | $195,456 | $2 million | 2025-06 |
| Pilot Light Incorporated | Arts, culture and humanities | 501(c)(3) | 2017 | $194,593 | $4,394 | 2024-12 |
| A 1 Learning Connections | Education | 501(c)(3) | 2014 | $192,772 | $54,239 | 2024-12 |
| Apartment Association of Greater Knoxville Inc | 501(c)(6) | 1995 | $191,564 | $85,632 | 2024-12 | |
| Halls Community Park Incorporated | Recreation and sports | 501(c)(3) | 2010 | $187,522 | $109,421 | 2025-12 |
| Knoxville Post No 2 American Legion | Public and societal benefit | 501(c)(19) | 2025 | $186,651 | $601,738 | 2024-06 |
| Progressive Media Inc | Religion-related | 501(c)(3) | 2004 | $184,830 | $0 | 2025-12 |
| Knoxville Internationals Network - Kin | Religion-related | 501(c)(3) | 2014 | $183,479 | $102,663 | 2025-12 |
| Appalachian Equality Chorus | Arts, culture and humanities | 501(c)(3) | 2014 | $183,218 | $38,567 | 2026-06 |
| Breast Connect Inc | Health care | 501(c)(3) | 2015 | $182,116 | $194,085 | 2025-12 |
| Justice Knox | Mental health and crisis intervention | 501(c)(3) | 2018 | $179,867 | $50,030 | 2025-12 |
| Halls Band Boosters Inc | Education | 501(c)(3) | 2005 | $177,455 | $62,001 | 2026-05 |
| Bike Walk Tennessee | Recreation and sports | 501(c)(3) | 2011 | $174,667 | $201,463 | 2025-12 |
| East Tennessee Kidney Foundation Inc | Diseases, disorders and medical disciplines | 501(c)(3) | 2010 | $174,597 | $292,015 | 2025-06 |
| Country Dance & Song Society Inc | Arts, culture and humanities | 501(c)(3) | 1993 | $173,957 | $92,917 | 2025-09 |
| Rotary International | 501(c)(4) | 1942 | $173,045 | $76,825 | 2025-06 | |
| Jubilee Community Arts Inc | Arts, culture and humanities | 501(c)(3) | 1980 | $173,010 | $196,384 | 2024-12 |
| Tennessee Alpha Alumni and Volunteer Corporation | Education | 501(c)(7) | 2020 | $172,883 | $2 million | 2025-06 |
| Good Samaritan Center of Hope | Religion-related | 501(c)(3) | 2014 | $172,546 | $152,252 | 2025-12 |
| Compassion Ministry Inc | Human services | 501(c)(3) | 2019 | $171,204 | $510,829 | 2025-12 |
| Chairmans Club | Human services | 501(c)(3) | 2019 | $170,281 | $6,279 | 2025-12 |
| National Academy Championship Finals Inc | Medical research | 501(c)(3) | 2006 | $169,193 | $32,072 | 2024-12 |
| Tva Retirees Association | Employment | 501(c)(4) | 2017 | $167,798 | $149,892 | 2025-12 |
| International Association of Lions Clubs | 501(c)(3) | 1991 | $166,693 | $655,115 | 2024-12 | |
| Autism Opened Door Project | Diseases, disorders and medical disciplines | 501(c)(3) | 2011 | $166,286 | $97,587 | 2025-12 |
| Farm House Fraternity Inc | 501(c)(7) | 1977 | $164,522 | $9,974 | 2025-12 | |
| YWCA Knoxville Foundation | Human services | 501(c)(3) | 2017 | $163,294 | $1.8 million | 2025-12 |
| Tennessee Recovery Alliance | Mental health and crisis intervention | 501(c)(3) | 2019 | $161,397 | $25,487 | 2025-12 |
| Strategic Cities Foundation | Religion-related | 501(c)(3) | 2016 | $160,855 | $106,799 | 2025-12 |
| Knoxville Scottish Rite Foundation Inc | Human services | 501(c)(3) | 1989 | $160,212 | $1.2 million | 2025-12 |
| Cattywampus Puppet Council | Arts, culture and humanities | 501(c)(3) | 2024 | $159,379 | $56,727 | 2025-12 |
| Carolinas Association of Chamber of Commmerce Executives Inc | 501(c)(6) | 1995 | $158,120 | $155,895 | 2025-12 | |
| Pavilion Society Charitable Foundation Inc | Education | 501(c)(3) | 2013 | $158,024 | $1.3 million | 2025-12 |
| East Tennessee Historical Society Foundation | Arts, culture and humanities | 501(c)(3) | 2008 | $157,780 | $4.3 million | 2024-12 |
| Knoxville Football Club | Recreation and sports | 501(c)(3) | 2016 | $153,350 | $281,770 | 2024-12 |
| Nativity Pageant of Knoxville Inc | Arts, culture and humanities | 501(c)(3) | 2022 | $152,181 | $208,525 | 2025-03 |
| Society of the Holy Family | Religion-related | 501(c)(3) | 2022 | $152,057 | $167,360 | 2025-12 |
| Farragut High School Football Boosters Club Inc | 501(c)(3) | 1993 | $151,741 | $40,923 | 2025-12 | |
| Redeem All Ministries Inc | Religion-related | 501(c)(3) | 2018 | $151,287 | $54,869 | 2025-12 |
| Athletes Table | Recreation and sports | 501(c)(3) | 2021 | $150,947 | $29,831 | 2024-12 |
| Koinonia Network Inc | Religion-related | 501(c)(3) | 2023 | $150,516 | $125,501 | 2025-07 |
| Girls On the Run of Greater Knoxville Inc | Youth development | 501(c)(3) | 2005 | $149,017 | $65,471 | 2025-12 |
| Hazen Historical Museum Foundation Inc | 501(c)(3) | 1989 | $148,745 | $1.4 million | 2024-12 | |
| Battlefield Farm & Gardens | Food, agriculture and nutrition | 501(c)(3) | 2024 | $146,839 | $244,583 | 2025-12 |
| General Federation of Womens Club | Community improvement and capacity building | 501(c)(3) | 1985 | $146,766 | $882,625 | 2025-04 |
| Honorair - Knoxville Inc | Public and societal benefit | 501(c)(3) | 2010 | $145,584 | $151,277 | 2025-12 |
| Resources for the Blind International Inc | International, foreign affairs and national security | 501(c)(3) | 1994 | $142,061 | $69,703 | 2025-12 |
| Chainfree USA | Animal-related | 501(c)(3) | 2021 | $141,964 | $102,278 | 2024-12 |
| The Partnership Initiatives Fund | 501(c)(3) | 1988 | $141,566 | $1.3 million | 2025-06 | |
| The Tennessee Association of Community Action | 501(c)(3) | 1987 | $141,507 | $173,038 | 2025-06 | |
| Governor John Sevier Memorial Association | 501(c)(3) | 1980 | $141,315 | $108,093 | 2025-06 | |
| Fountain City Ministry Center Inc | Food, agriculture and nutrition | 501(c)(3) | 2004 | $140,380 | $287,082 | 2024-12 |
| Kappa Sigma Fraternity | 501(c)(2) | 1975 | $140,119 | $506,640 | 2025-06 | |
| Down Syndrome Awareness Group of East Tennessee | 501(c)(3) | 1992 | $139,169 | $224,261 | 2025-06 | |
| International Alliance Theatrical Stage Employees & Moving Picture | 501(c)(5) | 1967 | $139,100 | $78,283 | 2023-12 |
By cause in Knoxville, TN
- Religion-related 301
- Education 279
- Human services 196
- Recreation and sports 147
- Arts, culture and humanities 136
- Philanthropy, voluntarism and grantmaking foundations 111
- Community improvement and capacity building 91
- Health care 69
- Youth development 67
- Animal-related 44
- Mental health and crisis intervention 42
- Public and societal benefit 36
- Housing and shelter 35
- Environment 32
- International, foreign affairs and national security 32
- Mutual and membership benefit 26
- Food, agriculture and nutrition 25
- Diseases, disorders and medical disciplines 23
- Employment 18
- Crime and legal-related 16
- Medical research 15
- Civil rights, social action and advocacy 15
- Public safety, disaster preparedness and relief 14
- Science and technology 13
- Social science 5
Nonprofits in every city of the state
Read from the IRS Exempt Organizations Business Master File, updated by the IRS on October 24, 2026 and rebuilt here every morning. Revenue and assets are from each organization's latest filing as the IRS lists it; the IRS record is the official one. Organizations only: no people are named on these pages.