Data / Nonprofits / Iowa / Des Moines
Nonprofits in Des Moines, IA: 7,844 registered with the IRS
7,844 nonprofits are registered with the IRS in Des Moines, IA, 1,296 of them 501(c)(3) charities; the 704 that report revenue took in $7.34 billion. The largest by revenue: Wells Fargo & Company Employee Benefit Trust ($2.67 billion), Central Iowa Hospital Corporation ($1.36 billion), Catholic Health Initiatives-Iowa Corp ($1.05 billion). Most common causes: education (158), human services (116), religion-related (112).
SpecStream is the live web data engine for teams and agents. It reads the IRS register of exempt organizations as the IRS updates it, and this page is that reading. Ask for the nonprofits you need by place, cause and size, with their latest Form 990 figures and websites, and they arrive in your sheet, CRM, Slack or agent.
The 500 largest by revenue
| Organization | Category | Type | Since | Revenue | Assets | Filing |
|---|---|---|---|---|---|---|
| Wells Fargo & Company Employee Benefit Trust | 501(c)(9) | 1979 | $2.67 billion | $14.1 million | 2024-12 | |
| Central Iowa Hospital Corporation | Health care | 501(c)(3) | 1948 | $1.36 billion | $1.78 billion | 2024-12 |
| Catholic Health Initiatives-Iowa Corp | Health care | 501(c)(3) | 1946 | $1.05 billion | $1.42 billion | 2025-06 |
| Drake University | Education | 501(c)(3) | 1950 | $256.3 million | $628.3 million | 2025-06 |
| Community FDN of Greater Des Moines | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 1995 | $160.8 million | $918.7 million | 2024-12 |
| Wells Fargo & Company Short Term Disability Plan & Trust | Mutual and membership benefit | 501(c)(9) | 2019 | $121.4 million | $21.4 million | 2025-12 |
| The Principal Trust for Health Bens for Ees and Non-Medicare Elig Rets | 501(c)(9) | 1992 | $77.2 million | $201.7 million | 2024-12 | |
| Grand View University | Education | 501(c)(3) | 1939 | $66.1 million | $116.5 million | 2025-06 |
| Primary Health Care Inc | Health care | 501(c)(3) | 1994 | $65.7 million | $35.7 million | 2025-06 |
| Iowa Natural Heritage Foundation | Environment | 501(c)(3) | 1979 | $53.2 million | $156.1 million | 2025-06 |
| Food Bank of Iowa | Food, agriculture and nutrition | 501(c)(3) | 1982 | $50.8 million | $45.2 million | 2025-06 |
| Mercy Health Network Inc | 501(c)(3) | 1946 | $34.6 million | $443.4 million | 2025-06 | |
| Plumbers & Steamfitters H & W Trust Iowa State Bank Ttee | 501(c)(9) | 1977 | $32.5 million | $98 million | 2024-12 | |
| Iowa Laborers District Council Health and Welfare Plan | 501(c)(9) | 1977 | $32.2 million | $24.9 million | 2025-10 | |
| Habitat for Humanity International Inc | Housing and shelter | 501(c)(3) | 1986 | $30.8 million | $43.7 million | 2025-06 |
| Lutheran Services in Iowa Inc | Human services | 501(c)(3) | 1961 | $30.5 million | $27.4 million | 2025-12 |
| Visiting Nurse Services of Iowa | Health care | 501(c)(3) | 1942 | $30.4 million | $29.6 million | 2025-06 |
| Shell Oil Dental Assistance Plan | 501(c)(9) | 1982 | $26.6 million | $7.8 million | 2023-12 | |
| National Pork Producers Council | 501(c)(5) | 1970 | $26.2 million | $39.1 million | 2024-12 | |
| Des Moines Performing Arts | Community improvement and capacity building | 501(c)(3) | 1981 | $26.2 million | $51 million | 2025-06 |
| Iowa Health Foundation | Health care | 501(c)(3) | 1999 | $24.6 million | $223.4 million | 2024-12 |
| United Way of Central Iowa | 501(c)(3) | 1938 | $24 million | $37.5 million | 2025-06 | |
| Mercy College of Health Sciences | Religion-related | 501(c)(3) | 1946 | $23.2 million | $109.3 million | 2025-06 |
| Orchard Place | Mental health and crisis intervention | 501(c)(3) | 1997 | $22.8 million | $12.9 million | 2025-06 |
| P E O Foundation | Education | 501(c)(3) | 1962 | $21 million | $167.8 million | 2025-06 |
| Iowa Life and Health Insurance Guaranty Association | 501(c)(6) | 1988 | $20.6 million | $24.4 million | 2025-06 | |
| Eyerly-Ball Community Mental Health Services | Mental health and crisis intervention | 501(c)(3) | 1969 | $17.5 million | $13.2 million | 2024-12 |
| Iowa Jag Inc | Youth development | 501(c)(3) | 1999 | $17.2 million | $10.2 million | 2025-06 |
| Golf Charitable Foundation of Greater Des Moines | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 2017 | $16.4 million | $2.8 million | 2025-07 |
| Luther Park Health Center Inc | 501(c)(3) | 2014 | $16.4 million | $13.9 million | 2024-12 | |
| Young Mens Christian Association of Greater Des Moines | 501(c)(3) | 1938 | $16 million | $53.1 million | 2025-08 | |
| Institute for Community Alliances | Housing and shelter | 501(c)(3) | 1991 | $15.7 million | $6 million | 2025-06 |
| Iowa Hospital Association | 501(c)(6) | 1960 | $15.5 million | $19.3 million | 2024-12 | |
| Easter Seal Society of Iowa Inc | 501(c)(3) | 1953 | $15.3 million | $16.4 million | 2025-08 | |
| Children and Families of Iowa | Human services | 501(c)(3) | 1947 | $15.2 million | $26.4 million | 2025-06 |
| Iowa Legal Aid | Crime and legal-related | 501(c)(3) | 1977 | $14.3 million | $19 million | 2025-12 |
| Iowa State Education Association | 501(c)(5) | 1953 | $13.5 million | $19.5 million | 2025-08 | |
| Grand View Christian School Association Inc | Education | 501(c)(3) | 2014 | $13 million | $15.6 million | 2025-07 |
| Animal Rescue League of Iowa Incorporated | Animal-related | 501(c)(3) | 1949 | $13 million | $13.7 million | 2024-12 |
| Impact Community Action Partnership Inc | 501(c)(3) | 1977 | $12.9 million | $2 million | 2025-09 | |
| Scottish Rite Park Inc | 501(c)(3) | 1973 | $12.8 million | $32.5 million | 2025-10 | |
| Italian American Cultural Center | Arts, culture and humanities | 501(c)(3) | 1984 | $12.3 million | $14.7 million | 2025-12 |
| Blank Park Zoo Foundation Inc | Animal-related | 501(c)(3) | 1981 | $11.9 million | $28.5 million | 2025-03 |
| Greater Des Moines Botanical Garden | Environment | 501(c)(3) | 1970 | $11.8 million | $31.4 million | 2025-06 |
| Neighborhood Finance Corporation | Housing and shelter | 501(c)(3) | 1990 | $11.4 million | $114.2 million | 2024-12 |
| Greater Des Moines Partnership | Community improvement and capacity building | 501(c)(6) | 2000 | $11.1 million | $13.1 million | 2025-12 |
| Calvin Community | 501(c)(3) | 1967 | $11.1 million | $5.6 million | 2025-04 | |
| Mercy Foundation of Des Moines Iowa | Health care | 501(c)(3) | 1975 | $10.6 million | $99.4 million | 2025-06 |
| Invest DSM | Housing and shelter | 501(c)(3) | 2020 | $10.4 million | $27.1 million | 2025-12 |
| Iowa Confluence Water Trails | Environment | 501(c)(3) | 2023 | $10.4 million | $52.1 million | 2025-06 |
| Principal Trust for Life Insurance Benefits for Employees | Mutual and membership benefit | 501(c)(9) | 2004 | $10.2 million | $42.8 million | 2024-12 |
| Iowa Public Radio Inc | Arts, culture and humanities | 501(c)(3) | 2007 | $10.2 million | $16.5 million | 2025-06 |
| Central Iowa Sheet Metal Health Fund Trust | 501(c)(9) | 1994 | $9.6 million | $19.2 million | 2025-12 | |
| Edmundson Art Foundation Inc | Arts, culture and humanities | 501(c)(3) | 1949 | $9.4 million | $175.7 million | 2024-12 |
| Iowa Primary Care Association Inc | 501(c)(3) | 1989 | $9.2 million | $5 million | 2025-06 | |
| Bravo Greater Des Moines Inc | Arts, culture and humanities | 501(c)(3) | 2006 | $8.9 million | $11.3 million | 2025-06 |
| Peo Sisterhood International Chapter | 501(c)(4) | 1950 | $8.9 million | $95.1 million | 2025-06 | |
| Greater Des Moines Convention and Visitors Bureau Inc | 501(c)(6) | 1985 | $8.5 million | $5.4 million | 2025-06 | |
| Anawim Housing | 501(c)(3) | 1988 | $7.9 million | $12.7 million | 2024-12 | |
| Jensen Construction Company Group Trust | 501(c)(9) | 1988 | $7.8 million | $0 | 2025-09 | |
| Girl Scouts of Greater Iowa | 501(c)(3) | 1955 | $7.8 million | $15.5 million | 2025-09 | |
| House of Mercy | Mental health and crisis intervention | 501(c)(3) | 1989 | $7.8 million | $16.2 million | 2025-06 |
| Des Moines Area Religious Council | Human services | 501(c)(3) | 1989 | $7.5 million | $10.7 million | 2025-06 |
| Wakonda Club | 501(c)(7) | 1951 | $7.3 million | $14.7 million | 2025-12 | |
| Catholic Council for Social Concern Inc | 501(c)(3) | 1946 | $7.1 million | $7.9 million | 2025-06 | |
| Science Center of Iowa | Arts, culture and humanities | 501(c)(3) | 1966 | $7.1 million | $48.5 million | 2025-09 |
| Iowa State Fair Foundation | Recreation and sports | 501(c)(3) | 1992 | $7.1 million | $23.8 million | 2025-10 |
| Royal Ten Cate U S A Inc Health and Welfare Trust | 501(c)(9) | 1992 | $7 million | $82,920 | 2024-12 | |
| Bioconnect Iowa | Community improvement and capacity building | 501(c)(3) | 2013 | $6.9 million | $15.2 million | 2025-06 |
| Isu Veterinary Services Corporation | Education | 501(c)(3) | 2013 | $6.6 million | $8 million | 2025-06 |
| Iowa Insurance Guaranty Association | 501(c)(6) | 1973 | $6.6 million | $12.2 million | 2024-12 | |
| Proteus Inc | Employment | 501(c)(3) | 1983 | $6.4 million | $2.5 million | 2025-06 |
| Hoyt Sherman Place Foundation | Arts, culture and humanities | 501(c)(3) | 1995 | $6.1 million | $59 million | 2025-06 |
| Employee and Family Resources Inc | 501(c)(3) | 1965 | $6.1 million | $6.4 million | 2025-06 | |
| Iowa Individual Health Benefit Reinsurance Association | Mutual and membership benefit | 501(c)(26) | 2000 | $6 million | $8.4 million | 2024-12 |
| Iowa Association of Electric Cooperatives | 501(c)(6) | 1943 | $5.9 million | $3.7 million | 2025-08 | |
| Iowa Medical Education Collaborative | Education | 501(c)(3) | 2014 | $5.9 million | $0 | 2025-06 |
| Bridges of Iowa | Mental health and crisis intervention | 501(c)(3) | 2000 | $5.7 million | $10.6 million | 2025-12 |
| Anna K Meredith Endowment Trust | Arts, culture and humanities | 501(c)(3) | 1982 | $5.7 million | $59.3 million | 2025-12 |
| United Association of Journeymen & Apprentices of the Plumbing & Pipe | 501(c)(5) | 1941 | $5.7 million | $13.6 million | 2025-12 | |
| Aging Resources of Central Ia | Human services | 501(c)(3) | 1982 | $5.5 million | $2.5 million | 2025-06 |
| Bergman Academy | 501(c)(3) | 1979 | $5.5 million | $4.9 million | 2025-06 | |
| Iowa Jewish Senior Life Center | Health care | 501(c)(3) | 2020 | $5.5 million | $6.1 million | 2025-06 |
| P E O Educational Loan Fund | Education | 501(c)(3) | 1962 | $5.3 million | $99.2 million | 2025-06 |
| Central Iowa Shelter & Services | Housing and shelter | 501(c)(3) | 1998 | $5.1 million | $18.6 million | 2025-06 |
| Des Moines Symphony Association | Arts, culture and humanities | 501(c)(3) | 1959 | $5.1 million | $23 million | 2025-06 |
| Variety the Childrens Charity of Iowa | 501(c)(3) | 1965 | $5.1 million | $6.9 million | 2025-09 | |
| Hospice of North Iowa | Human services | 501(c)(3) | 1982 | $5.1 million | $27.1 million | 2025-06 |
| Des Moines Iron Workers Welfare Fund | 501(c)(9) | $5 million | $17.2 million | 2025-11 | ||
| Central Iowa Health Properties Corporation | 501(c)(2) | 1984 | $4.9 million | $22.7 million | 2024-12 | |
| Iowa Association of School Boards | 501(c)(4) | 1951 | $4.9 million | $7.9 million | 2025-06 | |
| Iowa Pipe Trades & Hvac Training Institute | 501(c)(5) | 1990 | $4.8 million | $7.7 million | 2024-12 | |
| International Brotherhood of Electrical Workers | Employment | 501(c)(5) | 1940 | $4.5 million | $21 million | 2026-06 |
| Des Moines Public Library Foundation | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 1999 | $4.4 million | $9.7 million | 2025-12 |
| Peo Program for Continuing Education | 501(c)(3) | 1974 | $4.3 million | $13.5 million | 2025-06 | |
| International Association for Food Protection Inc | 501(c)(3) | 1953 | $4 million | $5.8 million | 2025-08 | |
| Des Moines Metro Credit Union | 501(c)(1) | $4 million | $70.3 million | 2024-12 | ||
| International Union of Painters and Allied Trades | 501(c)(5) | 1941 | $3.9 million | $9.9 million | 2025-06 | |
| Joshua Christian Academy Inc | Education | 501(c)(3) | 2012 | $3.9 million | $3.9 million | 2025-12 |
| Hospice of Central Iowa Foundation | Human services | 501(c)(3) | 1984 | $3.9 million | $17.3 million | 2025-06 |
| Boys & Girls Clubs of Central Iowa Inc | Youth development | 501(c)(3) | 1964 | $3.9 million | $16.5 million | 2025-06 |
| Polk County Housing Trust Fund | Housing and shelter | 501(c)(3) | 2001 | $3.8 million | $14.2 million | 2025-06 |
| Beacon of Life | Housing and shelter | 501(c)(3) | 1986 | $3.8 million | $2.4 million | 2025-06 |
| In Concertcare | Health care | 501(c)(4) | 1997 | $3.8 million | $5.8 million | 2025-06 |
| Homes of Oakridge Human Services | Human services | 501(c)(3) | 1988 | $3.8 million | $7.1 million | 2025-12 |
| Des Moines Embassy Club | 501(c)(7) | 1948 | $3.7 million | $4.6 million | 2024-12 | |
| Dental Connections Inc | Health care | 501(c)(3) | 1951 | $3.5 million | $3.9 million | 2025-06 |
| Des Moines Community Playhouse | Arts, culture and humanities | 501(c)(3) | 1946 | $3.5 million | $13.5 million | 2025-08 |
| Peo Sisterhood International Chapter | 501(c)(4) | 1950 | $3.4 million | $5 million | 2026-03 | |
| Underground Plant Location Services Inc | 501(c)(6) | 1995 | $3.4 million | $6.1 million | 2025-12 | |
| Iowa State Bar Association | 501(c)(6) | 1953 | $3.3 million | $10 million | 2025-06 | |
| Center at Sixth | Community improvement and capacity building | 501(c)(3) | 2022 | $3.2 million | $6.1 million | 2024-12 |
| International Union of Operating Engineers-Local 234 | 501(c)(5) | 1966 | $3.2 million | $9.2 million | 2024-12 | |
| Ballet Theatre of Des Moines | Arts, culture and humanities | 501(c)(3) | 2002 | $3.1 million | $5.1 million | 2025-06 |
| Iowa Healthiest State Initiative | Health care | 501(c)(3) | 2013 | $3.1 million | $704,924 | 2025-09 |
| P E O Star Scholarship | Education | 501(c)(3) | 2010 | $3 million | $10.2 million | 2025-06 |
| Home Opportunities Made Easy Inc | Housing and shelter | 501(c)(3) | 1968 | $3 million | $4.7 million | 2025-06 |
| Iowa Rural Health Telecommunications Program | Community improvement and capacity building | 501(c)(6) | 2014 | $2.9 million | $4.6 million | 2024-12 |
| Portland General Electric Company Veba for Health Reimbursement Arra | Mutual and membership benefit | 501(c)(9) | 2005 | $2.9 million | $18.9 million | 2025-12 |
| Talent Collective DSM | Environment | 501(c)(3) | 1986 | $2.9 million | $11.4 million | 2025-06 |
| P E O Scholar Awards | Education | 501(c)(3) | 1996 | $2.9 million | $13.1 million | 2025-06 |
| Monsoon Asians & Pacific Islanders in Solidarity | Human services | 501(c)(3) | 2007 | $2.9 million | $4.1 million | 2025-09 |
| Downtown Des Moines Self-Supported Municipal Improvement District | Community improvement and capacity building | 501(c)(6) | 2003 | $2.8 million | $3.1 million | 2025-06 |
| Disability Rights Iowa | 501(c)(3) | 1985 | $2.6 million | $2.1 million | 2025-09 | |
| Iowa Association of Business & Industry | 501(c)(6) | 1942 | $2.5 million | $2 million | 2025-06 | |
| Iowa Motor Truck Assoc Inc 314 | 501(c)(6) | 1957 | $2.5 million | $4 million | 2025-09 | |
| Joppa | Human services | 501(c)(3) | 2010 | $2.5 million | $3.6 million | 2025-09 |
| P E O International Peace Scholarship Fund | International, foreign affairs and national security | 501(c)(3) | 1962 | $2.5 million | $9.2 million | 2025-06 |
| Freedom for Youth Ministries | Youth development | 501(c)(3) | 2004 | $2.5 million | $4.5 million | 2024-12 |
| Horizon Science Academy Des Moines | Education | 501(c)(3) | 2023 | $2.5 million | $1.6 million | 2025-06 |
| Iowa Migrant Movement for Justice | Crime and legal-related | 501(c)(3) | 2020 | $2.4 million | $1.1 million | 2025-12 |
| Iowa College Foundation | 501(c)(3) | 1953 | $2.3 million | $8.8 million | 2025-06 | |
| Riva Refugee & Immigrant Voices in Action | Human services | 501(c)(3) | 2013 | $2.3 million | $1.5 million | 2024-12 |
| Iowa Community Action Association | Human services | 501(c)(3) | 2021 | $2.3 million | $534,134 | 2025-09 |
| Kingdom Living Iowa | Human services | 501(c)(3) | 2020 | $2.3 million | $1.1 million | 2025-12 |
| Ronald McDonald House Charities of Central Iowa Inc | Health care | 501(c)(3) | 1979 | $2.3 million | $17.5 million | 2025-12 |
| Associated General Contractors of Iowa | 501(c)(6) | 1963 | $2.2 million | $3 million | 2025-12 | |
| Orchard Place Foundation | Human services | 501(c)(3) | 1983 | $2.2 million | $15.6 million | 2025-06 |
| Civic Music Association | Arts, culture and humanities | 501(c)(3) | 1974 | $2.2 million | $4 million | 2025-05 |
| Neighborhood Investment Corporation | Community improvement and capacity building | 501(c)(3) | 2002 | $2.2 million | $13.2 million | 2025-12 |
| Luther Park Apartments Inc | 501(c)(3) | 2014 | $2.2 million | $6.7 million | 2024-12 | |
| Iowa Coalition Against Sexual Assualt | 501(c)(3) | 1983 | $2.2 million | $931,534 | 2025-09 | |
| Junior Achievement of Central Iowa Inc | International, foreign affairs and national security | 501(c)(3) | 1994 | $2.2 million | $4.4 million | 2025-06 |
| Boy Scouts of America | Youth development | 501(c)(3) | 1965 | $2.1 million | $13.9 million | 2024-12 |
| International Association of Machinists & Aerospace Workers | 501(c)(5) | 1940 | $2.1 million | $794,021 | 2024-12 | |
| Iowa Scottish Rite Masonic Foundation | 501(c)(3) | 1962 | $2.1 million | $10.3 million | 2024-12 | |
| Foundation for Children and Families of Iowa | 501(c)(3) | 1984 | $2.1 million | $19.6 million | 2025-06 | |
| Families Forward | 501(c)(3) | 1986 | $2.1 million | $4.2 million | 2025-06 | |
| American Federation of State County & Municipal Employees | 501(c)(5) | 1957 | $2.1 million | $1.5 million | 2025-12 | |
| Unitypoint Broadlawns Psychiatry Education Foundation | Education | 501(c)(3) | 2019 | $2 million | $10,000 | 2025-06 |
| Big Brothers Big Sisters of Central Iowa Inc | 501(c)(3) | 1967 | $2 million | $4.3 million | 2025-06 | |
| Iowa Citizens for Community Improvement | Community improvement and capacity building | 501(c)(3) | 1979 | $2 million | $4.2 million | 2025-12 |
| Iowa Medical Society | 501(c)(6) | 1938 | $2 million | $8.8 million | 2024-12 | |
| Technology Association of Iowa | Community improvement and capacity building | 501(c)(6) | 2002 | $2 million | $1.9 million | 2024-12 |
| Iowa Soccer Association | Recreation and sports | 501(c)(3) | 1989 | $1.9 million | $795,750 | 2025-07 |
| Iowa Environmental Council | Environment | 501(c)(3) | 1996 | $1.9 million | $2.1 million | 2024-12 |
| International Association of Bridge Structural & Ornamental Iron Worke | 501(c)(5) | 1971 | $1.9 million | $9 million | 2026-06 | |
| American Civil Liberties Union Foundation of Iowa | Civil rights, social action and advocacy | 501(c)(3) | 1969 | $1.8 million | $3.1 million | 2025-03 |
| Roosevelt High School Foundation | Education | 501(c)(3) | 1985 | $1.8 million | $3.4 million | 2025-08 |
| Highland Perpetual Maintenance Society Inc | 501(c)(13) | 1952 | $1.8 million | $9.7 million | 2024-12 | |
| Iowa Area Development Group L C | 501(c)(6) | 2021 | $1.8 million | $3.1 million | 2025-12 | |
| Mainframe Studios | Arts, culture and humanities | 501(c)(3) | 2014 | $1.8 million | $9.4 million | 2025-12 |
| Consumer Credit of Des Moines | Human services | 501(c)(3) | 1997 | $1.7 million | $3 million | 2025-12 |
| Better Business Bureau of Des Moines Inc | 501(c)(6) | 1948 | $1.7 million | $2.3 million | 2024-12 | |
| Camp Fire | 501(c)(3) | 1969 | $1.7 million | $1.8 million | 2025-08 | |
| Iowa Oncology Research Association | Medical research | 501(c)(3) | 1978 | $1.7 million | $398,855 | 2025-07 |
| Peo Sisterhood International Chapter | 501(c)(4) | 1950 | $1.6 million | $761,064 | 2026-03 | |
| Iowa Association of Soil Conservation District Commission | Science and technology | 501(c)(3) | 1997 | $1.6 million | $307,885 | 2025-06 |
| Peo Sisterhood International Chapter | 501(c)(4) | 1971 | $1.6 million | $1.2 million | 2026-03 | |
| Cornerstone Family Church of Des Moines Iowa | 501(c)(3) | 1991 | $1.6 million | $2.8 million | 2023-12 | |
| Downtown Events Group Inc | Arts, culture and humanities | 501(c)(3) | 2005 | $1.6 million | $167,370 | 2025-12 |
| Des Moines Area Medical Education Consortium Inc | 501(c)(3) | 1994 | $1.5 million | $471,329 | 2025-06 | |
| Agribusiness Association of Iowa | 501(c)(5) | 1966 | $1.5 million | $1.2 million | 2025-09 | |
| International Association of Sheet Metal Air Rail & Transportation | Employment | 501(c)(5) | 2015 | $1.5 million | $1.8 million | 2026-06 |
| Latinas Unidas Por Un Nuevo Amanecer | Human services | 501(c)(3) | 2002 | $1.5 million | $398,872 | 2025-06 |
| Animal Rescue League of Iowa Foundation | 501(c)(3) | 2000 | $1.4 million | $14.5 million | 2024-12 | |
| Young Womens Resource Center | Human services | 501(c)(3) | 1976 | $1.4 million | $3.1 million | 2025-06 |
| Hispanic Educational Resources Inc | Education | 501(c)(3) | 2018 | $1.4 million | $846,691 | 2025-06 |
| Iowa Center for Economic Success | Community improvement and capacity building | 501(c)(3) | 2009 | $1.4 million | $1.7 million | 2025-06 |
| Peo Sisterhood International Chapter | 501(c)(4) | 1971 | $1.4 million | $1.1 million | 2026-03 | |
| Iowa Laborers-Employers Cooperation and Education Trust | 501(c)(5) | 1995 | $1.4 million | $2.3 million | 2024-12 | |
| Iowa Association of Community College Trustees | Education | 501(c)(4) | 1971 | $1.4 million | $3.4 million | 2025-06 |
| American Academy of Family Physicians | 501(c)(6) | 1950 | $1.4 million | $2.3 million | 2025-12 | |
| Peo Sisterhood International Chapter | 501(c)(4) | 1971 | $1.4 million | $1.2 million | 2026-03 | |
| Des Moines Art Festival Inc | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 1998 | $1.4 million | $486,844 | 2024-12 |
| Neighborhood Development Corp | Housing and shelter | 501(c)(3) | 2000 | $1.4 million | $7.4 million | 2025-12 |
| Abraham Lincoln High School Alumni Foundation | Education | 501(c)(3) | 1993 | $1.3 million | $4.6 million | 2026-05 |
| Des Moines Symphony Association Foundation | 501(c)(3) | 1985 | $1.3 million | $20 million | 2025-06 | |
| Peo Sisterhood International Chapter | 501(c)(4) | 1950 | $1.3 million | $1.3 million | 2026-03 | |
| Institute for Missionary Evangalism | Religion-related | 501(c)(3) | 1990 | $1.3 million | $802,210 | 2025-12 |
| Great Plains Action Society | Civil rights, social action and advocacy | 501(c)(3) | 2022 | $1.2 million | $1.2 million | 2024-12 |
| United Ways of Iowa | Community improvement and capacity building | 501(c)(3) | 2013 | $1.2 million | $401,842 | 2025-06 |
| Iowa Propane Education and Research Council | Community improvement and capacity building | 501(c)(6) | 2005 | $1.2 million | $562,680 | 2025-12 |
| East High School Alumni Foundation | 501(c)(3) | 1988 | $1.2 million | $7.1 million | 2024-12 | |
| Youth Law Center | Human services | 501(c)(3) | 1977 | $1.2 million | $1.3 million | 2025-06 |
| Coalition for Family & Childrens Services in Iowa Inc | 501(c)(3) | 1981 | $1.2 million | $838,283 | 2025-06 | |
| Lutheran Services in Iowa Charitable Foundation Inc | Human services | 501(c)(3) | 1985 | $1.2 million | $12.2 million | 2025-12 |
| United Auto Workers Local 450 | 501(c)(5) | 1941 | $1.1 million | $648,935 | 2025-12 | |
| Agape Pregnancy Center | Health care | 501(c)(3) | 1986 | $1.1 million | $3 million | 2025-12 |
| International Brotherhood of Teamsters | 501(c)(5) | 1941 | $1.1 million | $719,766 | 2025-12 | |
| Iowa Motor Carriers Foundation | 501(c)(3) | 1987 | $1.1 million | $7.9 million | 2025-09 | |
| Iowa Nutrient Research and Education Council | Environment | 501(c)(3) | 2016 | $1.1 million | $355,958 | 2025-12 |
| Des Moines Park & Recreation Foundation | Recreation and sports | 501(c)(3) | 1997 | $1.1 million | $5.3 million | 2024-12 |
| GDMCF Charitable Trust | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 2007 | $1.1 million | $106 | 2024-12 |
| National Alliance On Mental Illness-Iowa Inc | Mental health and crisis intervention | 501(c)(3) | 1971 | $1.1 million | $593,030 | 2025-12 |
| Premier Payee Inc | Human services | 501(c)(3) | 2012 | $1.1 million | $1.2 million | 2025-12 |
| Iowa Business Energy Coalition | Community improvement and capacity building | 501(c)(6) | 2016 | $1.1 million | $537,258 | 2025-12 |
| Coalition To Support Iowas Farmers | Community improvement and capacity building | 501(c)(6) | 2004 | $1.1 million | $278,437 | 2025-10 |
| Iowa Public Health Association Foundation | 501(c)(3) | 1974 | $1.1 million | $882,761 | 2025-12 | |
| Iowa Grocery Industry Association | 501(c)(6) | 1952 | $1 million | $2.1 million | 2025-12 | |
| Principal Trust for Medicare-Eligible Post-Retirement Medical Benefits | Mutual and membership benefit | 501(c)(9) | 2016 | $1 million | $25.1 million | 2024-12 |
| Children and Family Urban Ministries | Crime and legal-related | 501(c)(3) | 1994 | $1 million | $563,707 | 2024-12 |
| American Institute of Architects Iowa Chapter | 501(c)(6) | 1968 | $1 million | $1 million | 2025-12 | |
| American Federation of Labor & Congress of Industrial Orgs | 501(c)(5) | 1956 | $1 million | $118,456 | 2024-12 | |
| Homeward Iowa | Human services | 501(c)(3) | 2016 | $1 million | $998,766 | 2025-06 |
| Iowa Dental Association Genl Fund | 501(c)(6) | 1952 | $1 million | $1.9 million | 2025-06 | |
| Iupat District Council 81 Joint Apprenticeship and Training Trust | Education | 501(c)(3) | 2006 | $1 million | $3.2 million | 2025-06 |
| Peo Sisterhood International Chapter | 501(c)(4) | 1950 | $1 million | $632,318 | 2026-03 | |
| Childrens Learning Center | Human services | 501(c)(3) | 1985 | $974,578 | $370,165 | 2025-08 |
| Ethnic Minorities of Burma Advocacy and Resource Center of Iowa Inc | Human services | 501(c)(3) | 2024 | $970,126 | $790,456 | 2025-06 |
| Capital City Pride Des Moines | Human services | 501(c)(3) | 2018 | $961,034 | $332,714 | 2025-08 |
| Urban Dreams | Human services | 501(c)(3) | 1984 | $959,832 | $2.9 million | 2024-12 |
| Creative Visions | Employment | 501(c)(3) | 1997 | $946,629 | $232,252 | 2025-06 |
| Center for National Independence in Politics | 501(c)(3) | 1988 | $941,346 | $2.3 million | 2025-03 | |
| Peo Sisterhood International Chapter | 501(c)(4) | 1950 | $927,987 | $425,892 | 2026-03 | |
| American Legion | 501(c)(19) | 1946 | $911,170 | $741,865 | 2025-06 | |
| Peo Sisterhood International Chapter | 501(c)(4) | 1950 | $907,787 | $763,224 | 2026-03 | |
| Salisbury House Foundation | Arts, culture and humanities | 501(c)(3) | 1994 | $883,183 | $10.5 million | 2024-12 |
| Nisaa African Family Services | Arts, culture and humanities | 501(c)(3) | 2015 | $882,897 | $307,272 | 2025-06 |
| Peo Sisterhood International Chapter | 501(c)(4) | 1971 | $878,968 | $1.1 million | 2026-03 | |
| Camp Hertko Hollow Inc | Youth development | 501(c)(3) | 2003 | $860,254 | $2.3 million | 2025-12 |
| Building Fund of Cottey Jr College Intl CHPTR Peo Sisterhood | Education | 501(c)(3) | 1960 | $857,760 | $2.2 million | 2025-06 |
| By Degrees Foundation | 501(c)(3) | 1990 | $847,011 | $290,430 | 2025-06 | |
| Des Moines Film Society | Arts, culture and humanities | 501(c)(3) | 2015 | $837,959 | $3.6 million | 2024-12 |
| Iowa Legal Aid Foundation | Crime and legal-related | 501(c)(3) | 2006 | $833,718 | $1.7 million | 2025-12 |
| Luther Care Services | Human services | 501(c)(3) | 1976 | $829,849 | $2.8 million | 2024-12 |
| Jacobs Place | Housing and shelter | 501(c)(3) | 1983 | $794,140 | $2.4 million | 2024-12 |
| Holy Family School Innercity Youth Foundation | 501(c)(3) | 1946 | $782,231 | $20.9 million | 2026-06 | |
| Peo Sisterhood International Chapter | 501(c)(4) | 1950 | $776,119 | $492,326 | 2026-03 | |
| Ruth Harbor | Housing and shelter | 501(c)(3) | 1997 | $770,050 | $1.5 million | 2024-12 |
| Common Good Iowa | 501(c)(3) | 2021 | $767,432 | $407,565 | 2024-12 | |
| Iowa Association of Regional Councils Inc | 501(c)(6) | 1996 | $763,802 | $280,195 | 2025-06 | |
| Wonder Years Academy | 501(c)(3) | 2010 | $758,091 | $485,771 | 2024-12 | |
| Full Circle Recovery Community Center | Mental health and crisis intervention | 501(c)(3) | 2024 | $751,744 | $77,491 | 2025-06 |
| Peo Sisterhood International Chapter | 501(c)(4) | 1950 | $748,872 | $249,680 | 2026-03 | |
| The Arc of Iowa | 501(c)(3) | 1962 | $742,462 | $980,210 | 2025-12 | |
| International Union of Elevator Constructors | 501(c)(5) | 1967 | $740,062 | $1.8 million | 2025-06 | |
| Animal Lifeline of Iowa Inc | Animal-related | 501(c)(3) | 1993 | $725,966 | $2 million | 2025-12 |
| Peo Sisterhood International Chapter | 501(c)(4) | 1950 | $725,659 | $625,217 | 2026-03 | |
| American Legion Auxiliary | 501(c)(19) | 1946 | $723,301 | $242,051 | 2025-07 | |
| United Youth Academy Foundation Inc | Recreation and sports | 501(c)(3) | 2024 | $721,739 | $61,070 | 2024-12 |
| Iowa Independent Bankers | 501(c)(6) | 1973 | $721,142 | $1 million | 2025-12 | |
| Iowa Economic Alliance | Community improvement and capacity building | 501(c)(4) | 2021 | $718,611 | $675,294 | 2025-12 |
| Project Iowa | Human services | 501(c)(3) | 2011 | $717,404 | $1.9 million | 2025-06 |
| Peo Sisterhood International Chapter | 501(c)(4) | 1950 | $709,686 | $808,437 | 2026-03 | |
| Des Moines Skywalk Association | Community improvement and capacity building | 501(c)(4) | 1993 | $708,389 | $552,454 | 2025-12 |
| Rebuilding Together Greater Des | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 1997 | $705,491 | $128,951 | 2024-11 |
| Downtown Partnership Inc | 501(c)(6) | 1986 | $701,534 | $247,728 | 2025-12 | |
| Iowa Agriculture Literacy Foundation | Food, agriculture and nutrition | 501(c)(3) | 2014 | $700,685 | $284,385 | 2025-10 |
| Peo Sisterhood International Chapter | 501(c)(4) | 1967 | $696,506 | $480,594 | 2026-03 | |
| Safe Center of Iowa | Health care | 501(c)(3) | 2025 | $695,996 | $624,389 | 2025-12 |
| Central Iowa Sheet Metal Training Fund | 501(c)(5) | 1983 | $691,236 | $2.2 million | 2024-12 | |
| Iowa Biotechnology Association | 501(c)(6) | 1997 | $681,072 | $1.5 million | 2024-12 | |
| Wallace House Foundation-A Museum and Vice Presidential Library | Arts, culture and humanities | 501(c)(3) | 1989 | $679,587 | $2.2 million | 2025-12 |
| Iowa Safe Schools | Education | 501(c)(3) | 2016 | $677,289 | $183,705 | 2025-06 |
| Peo Sisterhood International Chapter | 501(c)(4) | 1971 | $664,317 | $318,510 | 2026-03 | |
| Central Iowa Trauma and Recovery Ce Nter | Mental health and crisis intervention | 501(c)(3) | 2018 | $663,233 | $125,895 | 2025-09 |
| Starts Right Here | Youth development | 501(c)(3) | 2018 | $661,943 | $1.7 million | 2025-06 |
| One Iowa | Civil rights, social action and advocacy | 501(c)(3) | 2008 | $661,063 | $517,827 | 2024-12 |
| Iowa Propane Gas Association | Community improvement and capacity building | 501(c)(6) | 1987 | $661,059 | $1.4 million | 2025-12 |
| Iowa Golf Association Foundation | Education | 501(c)(3) | 2010 | $657,184 | $5.6 million | 2024-12 |
| The Global Farmer Network Foundation | Food, agriculture and nutrition | 501(c)(3) | 2005 | $651,620 | $467,712 | 2025-12 |
| Des Moines Soccer Club | Recreation and sports | 501(c)(3) | 2021 | $649,112 | $498,752 | 2025-12 |
| Ancient & Accepted Scottish Rite of Free Masonry So Juris of USA | 501(c)(10) | 1940 | $647,243 | $5 million | 2024-12 | |
| Iowa Utility Association | 501(c)(6) | 1972 | $640,163 | $285,973 | 2024-12 | |
| Mid-America Regulatory Conference Inc | 501(c)(6) | 1965 | $634,739 | $541,280 | 2024-12 | |
| International Association of Fire Fighters | Employment | 501(c)(5) | 1959 | $627,225 | $585,304 | 2024-12 |
| Community Youth Concepts | Youth development | 501(c)(3) | 2009 | $624,461 | $2 million | 2025-06 |
| William G Stowe Memorial Foundation | Environment | 501(c)(3) | 2022 | $618,495 | $809,552 | 2025-12 |
| Federation of Iowa Insurers | 501(c)(6) | 1981 | $614,254 | $467,966 | 2025-11 | |
| Operative Plasterers & Cement Masons International Association | 501(c)(5) | 1953 | $613,869 | $844,942 | 2025-12 | |
| Peo Sisterhood International Chapter | 501(c)(4) | 1967 | $613,520 | $442,749 | 2026-03 | |
| St Johns Lutheran Foundation Inc | 501(c)(3) | 1982 | $601,205 | $6.3 million | 2025-12 | |
| Endowment Fund of Cottey Jr College CHPTR Peo Sisterhood | Education | 501(c)(3) | 1960 | $594,960 | $9.3 million | 2025-06 |
| Iowa Business Council | 501(c)(6) | 1987 | $580,198 | $797,372 | 2025-12 | |
| National Human Services Data Consortium | Science and technology | 501(c)(3) | 2014 | $578,736 | $486,779 | 2025-06 |
| Broadlawns Medical Center Foundation | Health care | 501(c)(3) | 2001 | $575,935 | $3.6 million | 2025-06 |
| Sckic Inc | Human services | 501(c)(3) | 2016 | $575,294 | $1.7 million | 2025-06 |
| Prevent Child Abuse Iowa | 501(c)(3) | 1980 | $570,080 | $457,557 | 2025-06 | |
| Greater Des Moines Public Art Foundation | Arts, culture and humanities | 501(c)(3) | 2004 | $558,675 | $3.5 million | 2025-12 |
| Peo Sisterhood International Chapter | 501(c)(4) | 1971 | $552,166 | $408,634 | 2026-03 | |
| Street Collective | Community improvement and capacity building | 501(c)(3) | 2009 | $548,333 | $490,795 | 2024-12 |
| Iowa Congolese Organization and Center for Healing | Human services | 501(c)(3) | 2018 | $548,318 | $91,206 | 2025-12 |
| Heavy Highway Contractors Association | 501(c)(5) | 1985 | $546,800 | $1.3 million | 2025-12 | |
| Peo Sisterhood International Chapter | 501(c)(4) | 1967 | $544,457 | $365,850 | 2026-03 | |
| Iowa Chiropractic Society Inc | 501(c)(6) | 1978 | $542,385 | $486,811 | 2024-12 | |
| Arts for the City Inc | Arts, culture and humanities | 501(c)(3) | 2009 | $538,003 | $355,835 | 2025-06 |
| American Mock Trial Association | Education | 501(c)(3) | 1993 | $533,939 | $824,734 | 2025-06 |
| Peo Sisterhood International Chapter | 501(c)(4) | 1950 | $529,471 | $258,074 | 2026-03 | |
| Iowa Hospital Education and Research Foundation | Health care | 501(c)(3) | 1972 | $528,500 | $5.3 million | 2024-12 |
| Iowa Council for International Understanding | International, foreign affairs and national security | 501(c)(3) | 1970 | $527,880 | $93,432 | 2025-06 |
| Polk County Medical Society | 501(c)(6) | 1948 | $519,308 | $1.1 million | 2025-12 | |
| Directors Council | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 2004 | $514,479 | $718,988 | 2025-09 |
| Grand View Child Development Center Inc | Human services | 501(c)(3) | 1996 | $511,329 | $377,050 | 2025-06 |
| Des Moines Water Works Park Foundation | Recreation and sports | 501(c)(3) | 2014 | $510,751 | $628,559 | 2024-12 |
| Ape Cognition & Communication Institute | Animal-related | 501(c)(3) | 2016 | $509,065 | $11 million | 2025-12 |
| Mission Cancer Foundation | Health care | 501(c)(3) | 2021 | $505,821 | $468,521 | 2024-12 |
| Mindspring Mental Health Alliance Inc | Arts, culture and humanities | 501(c)(3) | 1996 | $504,448 | $272,789 | 2025-12 |
| Urban & Community Forestry Society | 501(c)(6) | 1981 | $501,273 | $960,291 | 2025-12 | |
| Christ-Life Ministries Inc | Religion-related | 501(c)(3) | 2001 | $500,376 | $1.4 million | 2025-12 |
| Local 67 Training Program Trust | 501(c)(5) | 1976 | $499,656 | $1.4 million | 2025-11 | |
| Iowa Newspaper Foundation | 501(c)(3) | 1985 | $498,549 | $2.5 million | 2024-12 | |
| Holy Spirit Unity Church in America | Religion-related | 501(c)(3) | 2017 | $495,107 | $1.4 million | 2023-12 |
| Easter Seals Society of Iowa | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 1953 | $489,848 | $15 million | 2025-08 |
| Child Evangelism Fellowship Inc | Youth development | 501(c)(3) | 1972 | $478,255 | $755,706 | 2025-12 |
| Iowa Area Development Group L C | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 2003 | $475,985 | $3.8 million | 2025-12 |
| LCS Foundation | Human services | 501(c)(3) | 2017 | $472,429 | $121,395 | 2025-12 |
| JW Reed Christian Academy Inc | Education | 501(c)(3) | 2022 | $469,170 | $400,126 | 2024-12 |
| Iowa Dental Foundation | Education | 501(c)(3) | 1994 | $468,926 | $1 million | 2025-06 |
| Des Moines Educational Foundation | Education | 501(c)(3) | 2011 | $468,578 | $261,193 | 2025-06 |
| Des Moines Heritage Center | Arts, culture and humanities | 501(c)(3) | 2020 | $467,504 | $3.6 million | 2025-12 |
| American Civil Liberties Union | 501(c)(4) | 1970 | $467,329 | $946,621 | 2025-03 | |
| Iowa Arts in Education | Arts, culture and humanities | 501(c)(3) | 2014 | $464,535 | $178,858 | 2024-12 |
| Principal Trust for Post-Retirement Life Benefits for Employees | Mutual and membership benefit | 501(c)(9) | 2014 | $463,901 | $9.9 million | 2024-12 |
| Farm House Fraternity Inc | 501(c)(7) | 1977 | $460,541 | $3.2 million | 2025-09 | |
| Willkie House Incorporated | 501(c)(3) | 1949 | $458,389 | $1.1 million | 2025-06 | |
| Iowa Association of Business and Industry Foundation | Youth development | 501(c)(3) | 1985 | $458,044 | $1.2 million | 2025-06 |
| Interfaith Alliance of Iowa | Religion-related | 501(c)(3) | 1996 | $454,408 | $170,917 | 2025-12 |
| Genesis Inc | Youth development | 501(c)(3) | 2014 | $449,883 | $411,902 | 2024-12 |
| Central Iowa Center for Independent Living | Community improvement and capacity building | 501(c)(3) | 1991 | $448,514 | $127,575 | 2025-09 |
| Free Clinics of Iowa | Health care | 501(c)(3) | 1995 | $447,520 | $812,868 | 2025-06 |
| North High Alumni Foundation | Education | 501(c)(3) | 1996 | $447,458 | $2.8 million | 2025-06 |
| Run Genz | Civil rights, social action and advocacy | 501(c)(4) | 2021 | $441,089 | $68,048 | 2023-12 |
| Iowa Aces 360 | Mental health and crisis intervention | 501(c)(3) | 2020 | $440,312 | $160,957 | 2025-06 |
| Blank Park Endowment Corporation | Animal-related | 501(c)(3) | 2014 | $421,585 | $9.8 million | 2025-03 |
| Sherman Hill Association Inc | 501(c)(3) | 1977 | $418,925 | $142,360 | 2024-12 | |
| Peo Sisterhood International Chapter | 501(c)(4) | 1950 | $415,907 | $212,759 | 2026-03 | |
| Peo Sisterhood International Chapter | 501(c)(4) | 1950 | $415,046 | $207,874 | 2026-03 | |
| Peo Sisterhood International Chapter | 501(c)(4) | 1971 | $414,823 | $282,752 | 2026-03 | |
| Evergreen Terrace Inc | Housing and shelter | 501(c)(3) | 1995 | $411,455 | $1.4 million | 2025-06 |
| Knock and Drop Iowa | Food, agriculture and nutrition | 501(c)(3) | 2020 | $406,395 | $120,699 | 2024-12 |
| Peo Sisterhood International Chapter | 501(c)(4) | 1971 | $404,826 | $170,856 | 2026-03 | |
| Iowa State Fairgrounds Trust | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 2015 | $396,476 | $2.4 million | 2025-10 |
| Iowa Heavy Highway Labor Management Work Preservation Fund | 501(c)(5) | 1989 | $393,229 | $760,248 | 2026-06 | |
| Pursuit of Innovation | Youth development | 501(c)(3) | 2015 | $392,347 | $166,416 | 2025-12 |
| Latinas Latinos Al Exito Inc | 501(c)(3) | 2010 | $389,238 | $127,433 | 2025-06 | |
| Peo Sisterhood International Chapter | 501(c)(4) | 1950 | $387,526 | $414,357 | 2026-03 | |
| Johnston Urbandale Soccer Club LLC | Recreation and sports | 501(c)(3) | 1990 | $385,286 | $1.8 million | 2024-12 |
| Five Fires Foundation | Recreation and sports | 501(c)(3) | 2021 | $383,155 | $3.6 million | 2025-12 |
| Peo Sisterhood International Chapter | 501(c)(4) | 1950 | $376,506 | $244,425 | 2026-03 | |
| Jungle Vine Foundation Inc | Human services | 501(c)(3) | 2014 | $375,280 | $368,747 | 2024-12 |
| Iowa Center Loan Fund | Community improvement and capacity building | 501(c)(3) | 2022 | $369,185 | $2.1 million | 2025-06 |
| Polk County Credit Union | 501(c)(1) | $368,639 | $5.5 million | 2025-12 | ||
| American Postal Workers Union | 501(c)(5) | 1973 | $364,970 | $388,139 | 2024-12 | |
| Iowa State Bar Foundation | Crime and legal-related | 501(c)(3) | 1949 | $362,547 | $3.3 million | 2025-06 |
| Iowa Foundation for Agricultural Advancement | 501(c)(3) | 2023 | $359,608 | $626,369 | 2025-12 | |
| Patriots Foundation | Civil rights, social action and advocacy | 501(c)(3) | 2014 | $358,500 | $6,628 | 2024-12 |
| Ingersoll Grand Self-Supported Municipal Improvement District | Community improvement and capacity building | 501(c)(6) | 2017 | $354,444 | $154,631 | 2025-06 |
| Womens Reproductive Health Foundation | Medical research | 501(c)(3) | 2011 | $353,214 | $184,088 | 2024-12 |
| Iowa Manufactured Housing Association | 501(c)(6) | 1959 | $352,818 | $2.2 million | 2024-12 | |
| Iowa Center for Childrens Justice | Civil rights, social action and advocacy | 501(c)(3) | 2020 | $349,896 | $70,429 | 2025-12 |
| Stagewest Theater Company | Arts, culture and humanities | 501(c)(3) | 1999 | $349,243 | $323,637 | 2025-12 |
| Kick It Forward | Recreation and sports | 501(c)(3) | 2013 | $347,975 | $367,112 | 2024-12 |
| Peo Sisterhood International Chapter | 501(c)(4) | 1971 | $346,988 | $449,321 | 2026-03 | |
| Iowa Turfgrass Institute | Science and technology | 501(c)(3) | 1993 | $345,837 | $535,319 | 2026-03 |
| Amateur Athletic Union of the United States | 501(c)(3) | 1966 | $339,724 | $232,334 | 2025-08 | |
| Fraternal Order of Eagles | Mutual and membership benefit | 501(c)(8) | 1991 | $338,215 | $366,098 | 2025-05 |
| Home Builders Association of Iowa | 501(c)(6) | 1962 | $336,683 | $959,770 | 2025-12 | |
| Des Moines Wine Festival Foundation | Arts, culture and humanities | 501(c)(3) | 2003 | $335,832 | $246,553 | 2025-12 |
| Fairmount Park Senior Housing Inc | Housing and shelter | 501(c)(3) | 1997 | $335,510 | $1.1 million | 2025-06 |
| Latino Resources Inc | Human services | 501(c)(3) | 2003 | $335,259 | $97,439 | 2025-12 |
| Eat Greater Des Moines | Food, agriculture and nutrition | 501(c)(3) | 2016 | $332,554 | $226,929 | 2025-06 |
| Alliance for A Better Iowa | Civil rights, social action and advocacy | 501(c)(4) | 2022 | $332,280 | $141,402 | 2025-12 |
| Peo Sisterhood International Chapter | 501(c)(4) | 1950 | $331,138 | $364,888 | 2026-03 | |
| Iowa Taxpayers Association | 501(c)(4) | 1940 | $331,010 | $395,718 | 2024-12 | |
| Iowa Newspaper Association Inc | 501(c)(6) | 1951 | $326,783 | $635,693 | 2024-12 | |
| Veterans of Foreign Wars of the United States Dept of Iowa | 501(c)(19) | 1951 | $326,529 | $270,022 | 2023-06 | |
| Riverside Gardens Inc | Housing and shelter | 501(c)(3) | 1993 | $325,536 | $1 million | 2025-06 |
| Empower Tanzania | International, foreign affairs and national security | 501(c)(3) | 2009 | $324,554 | $287,617 | 2024-12 |
| Gamma Theta House Association of Kappa Kappa Gamma Fraternity | 501(c)(7) | 1994 | $323,846 | $713,658 | 2025-06 | |
| Lead DSM | Public and societal benefit | 501(c)(3) | 2006 | $322,564 | $181,587 | 2025-06 |
| Build Lincoln Higher Booster Club | Education | 501(c)(3) | 2023 | $315,321 | $353,139 | 2026-04 |
| Iowa Right To Life Committee Educational Fund | Civil rights, social action and advocacy | 501(c)(3) | 1988 | $315,053 | $437,684 | 2024-12 |
| Iowa Storm Water Education Partnership | Environment | 501(c)(3) | 2016 | $304,427 | $207,339 | 2025-06 |
| Disabled American Veterans Store Trustee Account | Human services | 501(c)(3) | 1994 | $301,383 | $2.6 million | 2025-06 |
| Alpha Womens Center | Health care | 501(c)(3) | 1994 | $300,196 | $440,711 | 2026-07 |
| Iowa Land Improvement Contractors Association | 501(c)(6) | 1966 | $299,404 | $665,814 | 2025-09 | |
| Love Inc Des Moines | Human services | 501(c)(3) | 2016 | $294,398 | $405,645 | 2025-12 |
| Iowa Board of Substance Abuse Certification | Mental health and crisis intervention | 501(c)(3) | 1993 | $289,509 | $228,357 | 2025-06 |
| Peo Sisterhood International Chapter | 501(c)(4) | 1971 | $288,763 | $136,520 | 2026-03 | |
| Apartments of River Trace Inc | Housing and shelter | 501(c)(3) | 2001 | $285,443 | $1.4 million | 2024-12 |
| Raise the Bar Initiative | Recreation and sports | 501(c)(3) | 2018 | $283,183 | $154,949 | 2026-06 |
| Tifereth Israel Synagogue Foundation | Mutual and membership benefit | 501(c)(3) | 2000 | $281,819 | $2.4 million | 2025-12 |
| Iowa Wholesale Beer Distributors Association | 501(c)(6) | $280,122 | $842,453 | 2024-12 | ||
| Iowa Great Lakes Foundation | Environment | 501(c)(3) | 2015 | $279,697 | $749,200 | 2024-12 |
| Iowa Lutheran Hospital Auxiliary | Health care | 501(c)(3) | 1965 | $274,028 | $372,686 | 2024-12 |
| Iowa Construction Career Institue Inc | 501(c)(3) | 1996 | $273,016 | $8.9 million | 2024-12 | |
| Dream Team Des Moines | Youth development | 501(c)(3) | 2020 | $272,104 | $259,375 | 2025-12 |
| Iowa Podiatry Society | 501(c)(6) | 1974 | $270,293 | $158,010 | 2025-04 | |
| American Water Works Association | Public and societal benefit | 501(c)(3) | 1969 | $269,740 | $410,148 | 2024-12 |
| Plymouth Nursery School | Education | 501(c)(3) | 1976 | $269,719 | $214,961 | 2026-06 |
| Heartland Youth Choir | Arts, culture and humanities | 501(c)(3) | 2004 | $267,370 | $92,481 | 2025-06 |
| Iowa Seed Assoc | 501(c)(6) | 1965 | $266,734 | $183,716 | 2025-09 | |
| Iowa Bird Rehabilitation | Animal-related | 501(c)(3) | 2018 | $263,670 | $123,909 | 2024-12 |
| Peo Sisterhood International Chapter | 501(c)(4) | 1950 | $263,097 | $242,994 | 2026-03 | |
| Harbor of Hope Mission | 501(c)(3) | 1984 | $262,236 | $212,850 | 2025-12 | |
| United Steelworkers | 501(c)(5) | 1940 | $261,551 | $1.1 million | 2025-12 | |
| Iowa Hunter Education Instructor Association | Public safety, disaster preparedness and relief | 501(c)(3) | 1999 | $260,141 | $150,230 | 2025-06 |
| Rotary International | 501(c)(4) | 1942 | $256,858 | $246,694 | 2025-06 | |
| Iowa Public Transit Association | 501(c)(6) | 1998 | $254,191 | $171,306 | 2025-06 | |
| Iowa Organic Association | Food, agriculture and nutrition | 501(c)(3) | 2008 | $253,138 | $63,206 | 2025-12 |
| Des Moines Consistory Building Trust | Education | 501(c)(3) | 1995 | $251,996 | $153,266 | 2024-12 |
| Iowa Library Association | 501(c)(6) | 1952 | $249,889 | $241,613 | 2024-12 | |
| Iowa Citizens for Community Improvement Action Fund | Food, agriculture and nutrition | 501(c)(4) | 2012 | $248,903 | $1.2 million | 2025-12 |
| Building Owners & Managers Association of Central Iowa | 501(c)(6) | 1950 | $245,588 | $443,953 | 2025-12 | |
| National Society To Prevent Blindness | 501(c)(3) | 1990 | $244,425 | $358,206 | 2025-03 | |
| Des Moines North High School Booster Club | Education | 501(c)(3) | 2015 | $243,744 | $194,462 | 2024-12 |
| Alliance for A Better Iowa Education Fund | Civil rights, social action and advocacy | 501(c)(3) | 2022 | $243,564 | $5,952 | 2025-12 |
| Fusedsm | 501(c)(6) | 1980 | $243,451 | $5,192 | 2024-12 | |
| Rams Baseball Club | Recreation and sports | 501(c)(3) | 2010 | $242,862 | $156,976 | 2025-12 |
| Des Moines Gay Mens Chorus | Arts, culture and humanities | 501(c)(3) | 2001 | $242,520 | $75,333 | 2025-06 |
| Greater Iowa Apartment Association | Community improvement and capacity building | 501(c)(6) | 2008 | $237,877 | $227,879 | 2024-12 |
| Iowa Interfaith Power and Light Iowa Faith and Climate Network | Environment | 501(c)(3) | 2009 | $236,374 | $207,538 | 2025-08 |
| American Postal Workers Union | 501(c)(5) | 1973 | $235,938 | $61,855 | 2024-12 | |
| National Association of Letter Carriers | 501(c)(5) | 1955 | $235,537 | $352,726 | 2025-12 | |
| Cfa Society of Iowa Inc | 501(c)(6) | 1981 | $232,842 | $248,490 | 2025-06 | |
| Peo Sisterhood International Chapter | 501(c)(4) | 1950 | $232,110 | $135,306 | 2026-03 | |
| 6TH Avenue Corridor | Community improvement and capacity building | 501(c)(3) | 2010 | $231,937 | $560,868 | 2025-12 |
| Iowa Independent School Tuition Organization | Education | 501(c)(3) | 2007 | $231,257 | $221,294 | 2025-12 |
| Rheumatology Association of Nevada Inc | Community improvement and capacity building | 501(c)(6) | 2018 | $229,778 | $335,855 | 2024-12 |
| Iowa Wild Life Federation | 501(c)(3) | 1973 | $229,350 | $216,656 | 2025-12 | |
| Grand View Christian School Foundation Inc | Education | 501(c)(3) | 2015 | $228,784 | $4.1 million | 2025-12 |
| Iowa Assisted Living Association | Community improvement and capacity building | 501(c)(6) | 2014 | $226,601 | $482,419 | 2025-12 |
| Peo Sisterhood International Chapter | 501(c)(4) | 1950 | $225,654 | $184,046 | 2026-03 | |
| National Association of Insurance and Financial Advisors-Iowa | 501(c)(6) | 1966 | $223,392 | $604,135 | 2024-12 | |
| Iowa Soccer Development Foundation Inc | Community improvement and capacity building | 501(c)(3) | 2020 | $221,568 | $4.2 million | 2024-12 |
| Des Moines Education Association | 501(c)(6) | 1965 | $220,347 | $453,266 | 2025-08 | |
| Rural School Advocates of Iowa | Education | 501(c)(4) | 2014 | $219,247 | $102,896 | 2025-06 |
| Des Moines Chapter of the Izaak Walton League of America | Environment | 501(c)(3) | 1972 | $218,955 | $351,835 | 2025-12 |
| Iowa County Attorneys Association Inc | 501(c)(6) | 1983 | $217,615 | $299,386 | 2025-06 | |
| American Federation of Labor & Congress of Industrial Orgs | 501(c)(5) | 1978 | $214,835 | $110,877 | 2026-06 | |
| Iowa Insurance Institute | 501(c)(6) | 1961 | $214,068 | $463,891 | 2024-12 | |
| Polk County Bar Association | 501(c)(6) | 1985 | $213,648 | $276,343 | 2024-12 | |
| Polk County Jail Ministries Inc | Religion-related | 501(c)(3) | 1995 | $213,244 | $409,872 | 2025-12 |
| Urban Education Network of Iowa | Education | 501(c)(4) | 2021 | $212,303 | $262,719 | 2025-06 |
| Landwerx | Food, agriculture and nutrition | 501(c)(3) | 2025 | $211,456 | $0 | 2024-12 |
| Peo Sisterhood International Chapter | 501(c)(4) | 1950 | $210,222 | $212,279 | 2026-03 | |
| B Well Foundation Inc | Education | 501(c)(3) | 2021 | $209,236 | $14,985 | 2024-06 |
| Faith Independent Assembly of God | 501(c)(3) | 1970 | $208,800 | $214,598 | 2024-12 | |
| Peo Sisterhood International Chapter | 501(c)(4) | 1971 | $208,009 | $137,995 | 2026-03 | |
| Society of Beta Sigma Psi | 501(c)(7) | 1966 | $205,633 | $1.5 million | 2025-03 | |
| Iowa Association of Christian Schools | Education | 501(c)(4) | 2019 | $205,486 | $154,326 | 2025-06 |
| Iowa Historical Foundation | Arts, culture and humanities | 501(c)(3) | 1989 | $202,563 | $662,375 | 2025-06 |
| Cross Outreach | Human services | 501(c)(3) | 2019 | $198,344 | $337,104 | 2025-12 |
| Sigma Alpha Epsilon Fraternity | 501(c)(7) | 1940 | $198,160 | $1.1 million | 2025-06 | |
| Des Moines Metropolitan Historical Buildings Preservation Trust | Arts, culture and humanities | 501(c)(3) | 1983 | $197,908 | $2.3 million | 2024-12 |
| Iowa Freedom of Information Council | Housing and shelter | 501(c)(3) | 1995 | $197,791 | $406,085 | 2024-12 |
| School of Mary-Montessori | Education | 501(c)(3) | 2013 | $196,878 | $119,231 | 2024-12 |
| Rheumatology Association of Minnesota and the Dakotas | Mutual and membership benefit | 501(c)(6) | 2019 | $196,475 | $426,580 | 2024-12 |
| Art House Convergence | Arts, culture and humanities | 501(c)(3) | 2024 | $195,888 | $375,397 | 2025-06 |
| Professional Developers of Iowa Inc | 501(c)(6) | 1989 | $193,975 | $144,516 | 2024-12 | |
| One Economy | Community improvement and capacity building | 501(c)(3) | 2019 | $193,720 | $528,871 | 2025-09 |
| Des Moines Womens Club Hoyt Sherman Place | 501(c)(3) | 1938 | $193,373 | $2.3 million | 2025-05 | |
| Peo Sisterhood International Chapter | 501(c)(4) | 1950 | $192,747 | $89,442 | 2026-03 | |
| Peo Sisterhood International Chapter | 501(c)(4) | 1950 | $190,381 | $132,602 | 2026-03 | |
| South Des Moines Girls Amateur Softball | Recreation and sports | 501(c)(3) | 2012 | $188,859 | $375,600 | 2025-12 |
| Des Moines Urban Experience | Community improvement and capacity building | 501(c)(3) | 2015 | $188,748 | $2,185 | 2024-12 |
| A M O S-A Metropolitan Organizing Strategy | Environment | 501(c)(4) | 1999 | $188,065 | $407,482 | 2026-06 |
| Iowa Dance Theatre | 501(c)(3) | 1983 | $186,905 | $303,991 | 2025-06 | |
| Empigo Academy Inc | Education | 501(c)(3) | 2024 | $183,107 | $17,145 | 2025-06 |
| Iowa Chamber Alliance | Community improvement and capacity building | 501(c)(6) | 2023 | $181,994 | $26,137 | 2025-12 |
| Iowa Medical Society Foundation | 501(c)(3) | 1954 | $181,694 | $2 million | 2024-12 | |
| Everybody Wins-Iowa Inc | Education | 501(c)(3) | 2004 | $180,819 | $152,728 | 2025-06 |
| Jewels Academy | Education | 501(c)(3) | 2013 | $179,244 | $126,578 | 2025-12 |
| Party On the Hill Inc | Arts, culture and humanities | 501(c)(3) | 2024 | $178,633 | $22,624 | 2025-12 |
| Rotary Club of Des Moines Foundation | International, foreign affairs and national security | 501(c)(3) | 1983 | $177,086 | $2.8 million | 2025-06 |
| Concepts Cares Foundation | Public and societal benefit | 501(c)(3) | 2016 | $176,384 | $39,213 | 2025-12 |
| Emmanuel Chin Baptist Church | Religion-related | 501(c)(3) | 1955 | $175,934 | $62,688 | 2022-12 |
| Pivotal Business Partners | 501(c)(4) | 1986 | $175,106 | $93,517 | 2024-06 | |
| Peo Sisterhood International Chapter | 501(c)(4) | 1950 | $173,070 | $193,830 | 2026-03 | |
| Plymouth Place Inc | Housing and shelter | 501(c)(3) | 1965 | $172,622 | $8.9 million | 2025-06 |
| Alano Society Inc | Arts, culture and humanities | 501(c)(3) | 2020 | $171,844 | $262,044 | 2026-04 |
| Wat Lao Buddhavath of Iowa | Religion-related | 501(c)(3) | 2005 | $171,208 | $146,178 | 2025-12 |
| Pony Express Riders of Iowa | 501(c)(3) | 1978 | $171,173 | $117,970 | 2025-05 | |
| Amos Institute of Public Life | Human services | 501(c)(3) | 2011 | $170,089 | $198,084 | 2025-06 |
| Eastview Community Center | Community improvement and capacity building | 501(c)(3) | 2022 | $169,559 | $150,948 | 2025-12 |
| International Alliance Theatrical Stage Employees & Moving Picture | 501(c)(5) | 1941 | $168,704 | $95,937 | 2025-12 | |
| Little League Baseball Inc | 501(c)(3) | 1967 | $168,509 | $73,589 | 2025-12 | |
| Westside Early Education | Education | 501(c)(3) | 2013 | $167,016 | $1 | 2026-06 |
| International Association of Heat & Frost Insulators & Allied Workers | 501(c)(5) | 1940 | $166,541 | $380,454 | 2024-12 | |
| Royal Order of Jesters | 501(c)(10) | 1941 | $165,492 | $57,158 | 2025-12 | |
| Iowa Nonprofit Alliance | Community improvement and capacity building | 501(c)(3) | 2022 | $165,287 | $29,113 | 2025-06 |
| Iowa Physicians Assistant Society | 501(c)(6) | 1979 | $164,791 | $397,500 | 2025-09 | |
| Forest Avenue Outreach | Youth development | 501(c)(3) | 2013 | $164,410 | $187,225 | 2024-12 |
| Des Moines Obedience Training Club | 501(c)(4) | 1997 | $164,014 | $616,459 | 2025-12 | |
| Crew Iowa | Community improvement and capacity building | 501(c)(6) | 2012 | $163,592 | $263,641 | 2025-12 |
| Polk County Bar Association Volunteer Lawyers Project | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 1997 | $163,228 | $14,972 | 2025-06 |
| Agc of Iowa Foundation | Education | 501(c)(3) | 1997 | $163,152 | $2.1 million | 2025-12 |
| Iowa Academy of Trial Lawyers | 501(c)(6) | 1967 | $163,109 | $164,970 | 2025-12 | |
| American Federation of Labor & Congress of Industrial Orgs | 501(c)(5) | 1978 | $162,940 | $230,832 | 2025-12 |
By cause in Des Moines, IA
- Education 158
- Human services 116
- Religion-related 112
- Arts, culture and humanities 108
- Community improvement and capacity building 99
- Recreation and sports 80
- Philanthropy, voluntarism and grantmaking foundations 65
- Youth development 45
- Health care 39
- Employment 35
- Housing and shelter 34
- Civil rights, social action and advocacy 28
- International, foreign affairs and national security 26
- Environment 24
- Public and societal benefit 24
- Mutual and membership benefit 22
- Mental health and crisis intervention 22
- Crime and legal-related 22
- Food, agriculture and nutrition 17
- Animal-related 17
- Public safety, disaster preparedness and relief 6
- Medical research 5
- Science and technology 5
- Diseases, disorders and medical disciplines 5
Nonprofits in every city of the state
Read from the IRS Exempt Organizations Business Master File, updated by the IRS on October 24, 2026 and rebuilt here every morning. Revenue and assets are from each organization's latest filing as the IRS lists it; the IRS record is the official one. Organizations only: no people are named on these pages.