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Data / Research funding / Vascular Contributions to Cognitive Impairment and Dementia (VCID)

Vascular Contributions to Cognitive Impairment and Dementia (VCID): 790 NIH awards ($1.9B) to 179 organizations

790 NIH awards ($1.9B) in the NIH spending category Vascular Contributions to Cognitive Impairment and Dementia (VCID), to 179 organizations, read 2026-11-04. NIH fiscal years 2021 to 2025.

SpecStream is the live web data engine for teams and agents. It reads the NIH and NSF award files each time the agencies update them, and this page is that reading, joined to the open federal funding opportunities on Grants.gov. Ask for the awards you track by topic, organization or state and new awards arrive in your sheet, CRM, Slack or agent as the agencies publish them.

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NIH spending category

Awards

The 500 largest of 790 awards in the window.

AwardAgencyInstitute or divisionFiscal yearAmount in windowStartEndPrincipal investigatorSource
Alzheimer's Disease and Alzheimer's Disease Related Dementias in Prediabetes and Type 2 Diabetes: The Diabetes Prevention Program Outcomes Study AD/ADRD ProjectNIHNational Institute on Aging2022 to 2025$66,521,567September 1, 2022August 31, 2027LUCHSINGER, JOSE ALEJANDROreporter.nih.gov
ADRC Consortium for Clarity in ADRD Research Through ImagingNIHNational Institute on Aging2023 to 2024$60,357,563September 15, 2023August 31, 2028JOHNSON, STERLING Creporter.nih.gov
Alzheimer's Disease Sequencing Project Phenotype Harmonization ConsortiumNIHNational Institute on Aging2021 to 2025$37,497,984September 30, 2021August 31, 2026HOHMAN, TIMOTHY Jreporter.nih.gov
Cognitive training to reduce incidence of cognitive impairment in older adultsNIHNational Institute on Aging2021 to 2024$37,326,564February 1, 2021January 31, 2027O'BRIEN, JENNIFER LEEreporter.nih.gov
US POINTER Neuroimaging Ancillary StudyNIHNational Institute on Aging2021 to 2025$24,762,483August 1, 2019March 31, 2027LANDAU, SUSAN Mreporter.nih.gov
Metformin in Alzheimer's dementia Prevention (MAP)NIHNational Institute on Aging2021 to 2025$24,224,790August 15, 2019April 30, 2027LUCHSINGER, JOSE ALEJANDROreporter.nih.gov
Wisconsin Registry for Alzheimer's PreventionNIHNational Institute on Aging2023 to 2025$21,491,270June 1, 2023February 29, 2028JOHNSON, STERLING Creporter.nih.gov
Unraveling the earliest phases of vascular cognitive impairment and dementia using CADASIL--a monogenic form of small vessel cerebrovascular diseaseNIHNational Institute on Aging2021 to 2025$21,188,740September 30, 2021August 31, 2027PAULSEN, JANE Sreporter.nih.gov
Epidemiology of Age-related Dementia, Mild Cognitive Impairment and Brain Pathology in Cohort of Oldest-OldNIHNational Institute on Aging2022 to 2025$20,680,832September 15, 2017June 30, 2027WHITMER, RACHEL Areporter.nih.gov
Study of Latinos-Investigation of Neurocognitive Aging-Alzheimer's diseaseNIHNational Institute on Aging2022 to 2025$17,997,906May 15, 2022January 31, 2028GONZALEZ, HECTOR Mreporter.nih.gov
Subclinical Vascular Contributions to Alzheimer's Disease: The Multi-Ethnic Study of Atherosclerosis (MESA) Multisite Study of AD (Renewal)NIHNational Institute on Aging2021 to 2025$17,112,209August 15, 2018May 31, 2029HUGHES, TIMOTHY M.reporter.nih.gov
Offspring Study of Mechanisms for Racial Disparities in Alzheimer's DiseaseNIHNational Institute on Aging2021 to 2025$17,095,138September 1, 2016May 31, 2027MANLY, JENNIFER JAIEreporter.nih.gov
Diabetes and brain amyloid in middle aged HispanicsNIHNational Institute on Aging2021 to 2025$16,383,484September 1, 2015May 31, 2027LUCHSINGER, JOSE ALEJANDROreporter.nih.gov
Understanding Cohort Effects on Stroke, VCID, and Cognition After Major Epidemiologic TransitionsNIHNational Institute of Neurological Disorders and Stroke2024$16,244,011September 24, 2001August 31, 2026JUDD, SUZANNE Ereporter.nih.gov
Alzheimer's Disease Research CentersNIHNational Institute on Aging2021 to 2025$14,719,450September 1, 2020March 31, 2030CHUI, HELENA CHANGreporter.nih.gov
Integrative Pathways to Cognitive, Affective, and Brain HealthNIHNational Institute on Aging2022 to 2025$14,488,542September 30, 2022August 31, 2028RYFF, CAROL D.reporter.nih.gov
Mild Cognitive Impairment: A Prospective Community StudyNIHNational Institute on Aging2021 to 2025$14,337,476September 1, 2005April 30, 2026GANGULI, MARYreporter.nih.gov
Study of Healthy Aging in African AmericansNIHNational Institute on Aging2023 to 2025$14,240,222January 1, 2017May 31, 2028WHITMER, RACHEL Areporter.nih.gov
MACS/WIHS Combined Cohort Study: Brooklyn Clinical Research Site (Bklyn CRS)NIHNational Heart, Lung, and Blood Institute2021 to 2025$14,117,524April 1, 2019September 30, 2026GUSTAFSON, DEBORAH R.reporter.nih.gov
Vanderbilt Memory & Aging ProjectNIHNational Institute on Aging2021 to 2025$14,019,775March 15, 2011March 31, 2027JEFFERSON, ANGELA L.reporter.nih.gov
Epidemiological and Genetic Investigations of Blood-Based Biomarkers for Alzheimer's Disease in the Multiethnic, Washington Heights, Inwood, Columbia Aging Project (WHICAP)NIHNational Institute on Aging2021 to 2025$13,310,071June 1, 2021March 31, 2027MAYEUX, RICHARD Preporter.nih.gov
ARIC Neurocognitive Study (ARIC-NCS) Renewal 2023-2028NIHNational Heart, Lung, and Blood Institute2024 to 2025$13,305,831July 7, 2010March 31, 2029CORESH, JOSEFreporter.nih.gov
MIND DIET AND DEMENTIA PREVENTION IN ISCHEMIC STROKE PATIENTSNIHNational Institute on Aging2021 to 2025$13,186,351September 1, 2020May 31, 2027AGGARWAL, NEELUM T.reporter.nih.gov
Testing Hypothesized Pathways Linking Infection, Physical Activity, Apoe Genotype, And Biological Sex To Low Dementia Prevalence And Reduced Brain Atrophy In Two Native American PopulationsNIHNational Institute on Aging2022 to 2025$12,690,286April 15, 2017April 30, 2027KAPLAN, HILLARD Sreporter.nih.gov
Exploring Cognitive Aging Using Reference Ability Neural NetworksNIHNational Institute on Aging2021 to 2025$12,167,937September 1, 2011June 30, 2027STERN, YAAKOVreporter.nih.gov
I3C DECADE: Developmental Epidemiology of Childhood Cardiovascular Exposures and Alzheimer’s DementiaNIHNational Institute on Aging2022 to 2025$11,889,015July 1, 2022April 30, 2028MACLEHOSE, RICHARD Freporter.nih.gov
Estrogens, Cardiometabolic Health, and Female Cognitive AgingNIHNational Institute on Aging2022 to 2025$11,521,268March 1, 2022February 28, 2027DANIEL, JILL Mreporter.nih.gov
Sleep in Neurocognitive Aging and Alzheimers Research (SANAR)NIHNational Institute on Aging2021 to 2025$11,494,462February 1, 2021January 31, 2027RAMOS, ALBERTO RAFAELreporter.nih.gov
Impact of Neuroinflammation on AD Occurrence: A Bi-Generational Population StudyNIHNational Institute on Aging2021 to 2025$11,418,675September 1, 2021May 31, 2027RAJAN, KUMAR B.reporter.nih.gov
Racial Differences in Late-Life Cognitive decline and risk of Alzheimer's DiseaseNIHNational Institute on Aging2021 to 2025$11,402,108September 30, 2004May 31, 2027BARNES, LISA Lreporter.nih.gov
VCID Biomarkers Coordinating CenterNIHNational Institute of Neurological Disorders and Stroke2022 to 2025$10,493,954September 30, 2016June 30, 2027GREENBERG, STEVEN Mreporter.nih.gov
Vermont Center for Cardiovascular and Brain HealthNIHNational Institute of General Medical Sciences2021 to 2024$10,185,844August 6, 2020May 31, 2026CUSHMAN, MARYreporter.nih.gov
Longitudinal Relationships Among Sleep, Cognition and Alzheimer's Disease Biomarkers: Discerning Causal Associations, Mediators and SusceptibilityNIHNational Institute on Aging2021 to 2024$9,901,034May 1, 2021February 28, 2026REDLINE, SUSAN S.reporter.nih.gov
Impact of Intensive Treatment of Systolic Blood Pressure on Brain Perfusion, Amyloid and Tau in Older Adults (IPAT-study)NIHNational Institute on Aging2022 to 2025$9,488,371August 1, 2022July 31, 2027ZHANG, RONGreporter.nih.gov
BEACH: Biomarker and Edema Attenuation in IntraCerebral Hemorrhage Phase 2a TrialNIHNational Institute on Aging2021 to 2025$9,481,336February 15, 2021November 30, 2026HANLEY, DANIEL Freporter.nih.gov
The San Antonio Heart and Mind StudyNIHNational Institute on Aging2023 to 2025$9,286,743July 1, 2023March 31, 2029SATIZABAL, CLAUDIA Lreporter.nih.gov
African Americans Fighting Alzheimer’s in Midlife (AA-FAIM)NIHNational Institute on Aging2021 to 2025$9,250,399August 1, 2016November 30, 2027GLEASON, CAREY Ereporter.nih.gov
Assessing the role of cerebrovascular brain injury and dysfunction in Alzheimer’s disease pathogenesis in the BEACoN CohortNIHNational Institute on Aging2021 to 2025$9,240,061August 1, 2017December 31, 2027YASSA, MICHAEL Areporter.nih.gov
Investigating the Functional Impact of AD Risk Genes on Neuro-Vascular InteractionsNIHNational Institute on Aging2021 to 2025$8,654,669July 1, 2021June 30, 2027TEMPLE, SALLYreporter.nih.gov
P-CARRS-BRAIN: Multi-domain (genetic, socio-behavioral, vascular) risk factors and prediction of Alzheimer’s Disease continuum in South Asians in IndiaNIHNational Institute on Aging2024 to 2025$8,548,820September 15, 2024August 31, 2029NARAYAN, KABAYAM M VENKATreporter.nih.gov
Race / Ethncicity, Hypertension and Prevention of VCID and Stroke after Intracerebral HemmorrhageNIHNational Institute of Neurological Disorders and Stroke2022 to 2025$8,210,604February 1, 2016July 31, 2027ROSAND, JONATHANreporter.nih.gov
THE NIH PRECISION BRAIN HEALTH NETWORK: Open and Inclusive Measurement of Neuropsychological Change for AD/ADRD Primary Prevention TrialsNIHNational Institute on Aging2025$7,948,867August 1, 2025July 31, 2030SLIWINSKI, MARTIN Jreporter.nih.gov
ERICH-GENENIHNational Institute of Neurological Disorders and Stroke2021 to 2024$7,768,356August 1, 2010June 30, 2025DEMEL, STACIEreporter.nih.gov
The POINTER Neurovascular Ancillary StudyNIHNational Institute on Aging2021 to 2024$7,761,498April 15, 2020December 31, 2025BRINKLEY, TINA Ereporter.nih.gov
Vietnamese Insights into Cognitive Aging Program (VIP)NIHNational Institute on Aging2021 to 2025$7,598,841February 15, 2021May 31, 2026MEYER, OANH Lreporter.nih.gov
Look AHEAD Sleep: Sleep-disordered breathing, circadian rest/activity rhythms, and the risk of Alzheimer's disease and related dementias in Look AHEADNIHNational Institute on Aging2021 to 2025$7,592,411August 15, 2021May 31, 2027UDEH-MOMOH, CHINEDU THERESAreporter.nih.gov
REpeated ASseSsmEnt of SurvivorS in ICH (REASSESS ICH)NIHNational Institute of Neurological Disorders and Stroke2022 to 2025$7,516,765January 1, 2022December 31, 2027ZIAI, WENDY Creporter.nih.gov
Multidimensional Assessment of Brain Health as A Marker of Dementia Risk and ResilienceNIHNational Institute on Aging2021 to 2024$7,413,273September 15, 2020May 31, 2025SESHADRI, SUDHAreporter.nih.gov
CYCLE-AD: Randomized Controlled Trial to Assess the Efficacy of Indoor Cycling in Slowing Disease Progression in Healthy Older Persons at Genetic Risk for Alzheimer’s DiseaseNIHNational Institute on Aging2021 to 2025$7,389,501January 15, 2021December 31, 2026RAO, STEPHEN MARKreporter.nih.gov
Predictors of Altered CNS Structure, Function, and Connectomics in the Elderly using a Health Disparities FrameworkNIHNational Institute on Aging2022 to 2025$7,350,257February 15, 2022November 30, 2027COHEN, ANN D.reporter.nih.gov
Leveraging the 24-hour movement paradigm to preserve cognitive function and prevent Alzheimer's disease: The Multi-Ethnic Study of Atherosclerosis (MESA) 24H-ACT StudyNIHNational Institute on Aging2021 to 2024$7,263,372May 1, 2021April 30, 2026DIAZ, KEITH Mreporter.nih.gov
The VETSA Longitudinal MRI Twin Study of Aging (VETSA MRI 4)NIHNational Institute on Aging2022 to 2025$7,252,240June 1, 2022March 31, 2027ELMAN, JEREMY Areporter.nih.gov
A Pragmatic Trial of the UCSF Brain Health Assessment for the Detection of Cognitive Impairment in Primary CareNIHNational Institute of Neurological Disorders and Stroke2022 to 2025$6,593,404September 15, 2022August 31, 2027POSSIN, KATHERINE LAURELreporter.nih.gov
Extracranial Carotid Atherosclerosis Contributions to Cognitive Impairment and Alzheimer's Disease RiskNIHNational Institute on Aging2021 to 2025$6,475,434August 15, 2021May 31, 2027WEINKAUF, CRAIG Creporter.nih.gov
The biological underpinnings of Motoric Cognitive Risk syndrome: a multi-center studyNIHNational Institute on Aging2021 to 2024$6,442,962June 15, 2020March 31, 2025VERGHESE, JOEreporter.nih.gov
Moderation of Aging Trajectories of Cognition and Neuropathology by Diet Composition in Middle-aged Nonhuman PrimatesNIHNational Institute on Aging2025$6,424,607September 15, 2025September 14, 2029BAXTER, MARK Greporter.nih.gov
Contributions of stress reactivity to risk of Alzheimer's disease and related dementia's in a community-based cohortNIHNational Institute on Aging2021 to 2025$6,416,931September 30, 2021May 31, 2027KERSHAW, KIARRI Nreporter.nih.gov
Validation of the Remote Cognitive Aging and Alzheimer’s Disease REsearch (R-CARE) Toolbox for Diverse PopulationsNIHNational Institute on Aging2023 to 2025$6,381,700August 15, 2023May 31, 2028LIPTON, RICHARD B.reporter.nih.gov
Cerebral small vessel disease burden and racial disparity in vascular cognitive impairment and Alzheimer’s disease and its related dementiasNIHNational Institute on Aging2021 to 2025$6,336,090September 15, 2021May 31, 2027HYACINTH, HYACINTH IDUreporter.nih.gov
A Life Course Approach to Integrating Trauma and Cognitive Aging: A Cohort of 9/11 RespondersNIHNational Institute on Aging2021 to 2024$6,329,240May 15, 2015April 30, 2026CLOUSTON, SEANreporter.nih.gov
Validation of Biomarkers of Small Vessel Injury in VCIDNIHNational Institute of Neurological Disorders and Stroke2021 to 2023$6,258,167September 29, 2021July 31, 2026ROSENBERG, GARY ALLENreporter.nih.gov
Washington University University of Texas Southwestern VCID Consortium SiteNIHNational Institute of Neurological Disorders and Stroke2021 to 2023$6,224,729September 29, 2021July 31, 2026LEE, JIN-MOOreporter.nih.gov
IND Enabling Studies for a Novel Mas Receptor Agonist for Treatment of Cognitive Impairment in Patients at Risk for Alzheimer's Disease Related DementiaNIHNational Institute on Aging2021 to 2023$6,168,197April 15, 2020March 31, 2024HAY, MEREDITHreporter.nih.gov
The University of Kentucky MarkVCID Biomarker Validation Cohort: Development of a Toolbox to Advance VCID Interventional StudiesNIHNational Institute of Neurological Disorders and Stroke2021 to 2023$6,120,000September 29, 2021July 31, 2026JICHA, GREGORY Areporter.nih.gov
MarkVCID Validation in the General CommunityNIHNational Institute of Neurological Disorders and Stroke2021 to 2023$6,100,999September 23, 2021July 31, 2026PETERSEN, RONALD Creporter.nih.gov
VCID CWOW: Identifying Novel Targets to Treat Cerebral Amyloid AngiopathyNIHNational Institute of Neurological Disorders and Stroke2024$5,949,022September 18, 2024August 31, 2027HOWELL, GARETH Rreporter.nih.gov
URBAn Native Elders (URBANE): Risk and Protective Factors for Alzheimer's and Related DementiasNIHNational Institute on Aging2021 to 2024$5,941,036September 1, 2019May 31, 2026NELSON, LONNIE A.reporter.nih.gov
PNA5: A Novel Mas Receptor Agonist for Treatment of Cognitive Impairment in Patients at Risk for Vascular Dementia and Alzheimer's Disease Related Dementia: an FDA required Toxicology StudyNIHNational Institute on Aging2023 to 2025$5,906,221September 1, 2023August 31, 2027HAY, MEREDITHreporter.nih.gov
Examining Effects of Intensive BP Control on MCI/Dementia and Plasma Biomarker Trajectories by AD Pathology: Elucidating neuroprotective effects in the racially and ethnically diverse SPRINT trialNIHNational Institute on Aging2025$5,789,766September 30, 2025June 30, 2030BRESS, ADAM Preporter.nih.gov
Cerebral tau deposition and comorbid cerebrovascular disease across the Alzheimer's disease continuum in Mexican AmericansNIHNational Institute on Aging2024 to 2025$5,730,361August 15, 2024August 31, 2029HABES, MOHAMADreporter.nih.gov
Brain pathologies, reserve and cognition in aging and dementiaNIHNational Institute on Aging2022 to 2025$5,694,414March 1, 2009March 31, 2027TOMASZEWSKI-FARIAS, SARAH Ereporter.nih.gov
Reducing Disparities in Dementia and VCID Outcomes in a Multicultural Rural PopulationNIHNational Institute of Neurological Disorders and Stroke2021 to 2023$5,484,212March 6, 2020March 21, 2025GALVIN, JAMES Ereporter.nih.gov
Vascular-immune mechanisms of cerebral amyloid angiopathy and Alzheimer's pathologyNIHNational Institute of Neurological Disorders and Stroke2024$5,423,836September 19, 2024August 31, 2027YANG, ANDREW CHRISreporter.nih.gov
Environmental Exposures and Brain HealthNIHNational Institute on Aging2025$5,164,012September 1, 2025August 31, 2029JAMES, PETERreporter.nih.gov
Microbial Impact on NeuroDegeneration in Alzheimer's Dementia: MIND-ADNIHNational Institute on Aging2021 to 2025$5,121,493September 30, 2021May 31, 2027SPIRA, ADAM PETERreporter.nih.gov
A Precision Medicine Approach for the Study of Targetable Pathways in Vascular DementiaNIHNational Institute on Aging2022 to 2025$5,086,657February 1, 2022November 30, 2026GOATE, ALISON Mreporter.nih.gov
Brain Health and Ethnic Disparities in ADRD Risk: The Case of Arab AmericansNIHNational Institute on Aging2021 to 2025$5,040,162April 1, 2021March 31, 2027ANTONUCCI, TONI CLAUDETTEreporter.nih.gov
Multi-scale and multi-modality imaging of neuropathology in VCIDNIHNational Institute of Neurological Disorders and Stroke2023 to 2025$4,964,481September 22, 2023August 31, 2028GE, YULINreporter.nih.gov
Characterizing Cognitive Decline in Late Life Depression: The ADNI-D ProjectNIHNational Institute of Mental Health2022 to 2025$4,842,533August 1, 2013May 31, 2027MACKIN, ROBERT SCOTTreporter.nih.gov
Vasculo-neuronal pathophysiological interface in Alzheimer’s and AtherosclerosisNIHNational Institute of Neurological Disorders and Stroke2024$4,815,513September 18, 2024August 31, 2027IRUELA-ARISPE, M. LUISAreporter.nih.gov
Novel retinal higher-order capillary hemodynamics imaging for detecting cerebral small vessel diseaseNIHOffice of the Director, National Institutes of Health2024 to 2025$4,719,171September 15, 2024September 14, 2027WANG, JIANHUAreporter.nih.gov
Defining the molecular spectrum of white matter vascular lesionsNIHNational Institute of Neurological Disorders and Stroke2024$4,693,249September 17, 2024August 31, 2027HINMAN, JASON Dreporter.nih.gov
An Acquisition and Analysis Pipeline for Integrating MRI and Neuropathology in TBI-related Dementia and VCIDNIHNational Institute of Neurological Disorders and Stroke2023 to 2025$4,539,313September 22, 2023August 31, 2028VAN DER KOUWE, ANDRE JAN WILLEMreporter.nih.gov
Capillaries as a Sensory Web that Controls Cerebral Blood Flow in Health and DiseaseNIHNational Heart, Lung, and Blood Institute2021 to 2025$4,511,697January 1, 2019December 31, 2026NELSON, MARK Treporter.nih.gov
A global epidemiology of cognitive impairment and dementia due to Alzheimer's disease and related disorders: the COSMIC CollaborationNIHNational Institute on Aging2023 to 2025$4,445,528September 15, 2017June 30, 2028SACHDEV, PERMINDER Sreporter.nih.gov
Cognitive Impairment and Dementia, Vascular Brain Injury, and Atrial Myopathy: Implications for Prevention of Alzheimer's Disease-Related DementiasNIHNational Institute of Neurological Disorders and Stroke2023$4,390,219September 20, 2023August 31, 2026CHEN, LIN YEEreporter.nih.gov
Precursors of Stroke Incidence and PrognosisNIHNational Institute of Neurological Disorders and Stroke2023 to 2025$4,368,194December 1, 1981August 31, 2028ROMERO, JOSE RAFAELreporter.nih.gov
VCID Center Without Walls for Understanding and Leveraging Small Vessel Cerebrovascular Disease Mechanisms in ADRDNIHNational Institute of Neurological Disorders and Stroke2024$4,361,625September 24, 2024August 31, 2027LEE, JIN-MOOreporter.nih.gov
Spreading Tau Pathology in Non-Amnestic Alzheimer's DiseaseNIHNational Institute on Aging2021 to 2025$4,306,312July 1, 2018June 30, 2028PHILLIPS, JEFFREY Sreporter.nih.gov
Leveraging novel mouse models to investigate toxic metal exposures on brain aging and Alzheimer's diseaseNIHNational Institute on Aging2024 to 2025$4,141,255September 30, 2024August 31, 2029GOLDSTEIN, LEE E.reporter.nih.gov
Structural and diffusion changes of perivascular space in aging, cognitive decline and Alzheimer's diseaseNIHNational Institute on Aging2021 to 2025$4,101,683September 5, 2021June 30, 2027CHOUPAN, JEIRANreporter.nih.gov
Validation of small vessel vascular contributions to cognitive impairment and dementia (VCID) biomarkersNIHNational Institute of Neurological Disorders and Stroke2023 to 2025$4,093,112September 30, 2016July 31, 2027LU, HANZHANGreporter.nih.gov
Vascular Pathology in Early and Asymptomatic Cerebral Amyloid AngiopathyNIHNational Institute on Aging2021 to 2025$3,993,325September 30, 2014March 31, 2027VISWANATHAN, ANANDreporter.nih.gov
Building an unbiased pooled cohort for the study of lifecourse social and vascular determinants of Alzheimer's Disease and Related DisordersNIHNational Institute on Aging2021 to 2025$3,985,562June 15, 2021March 31, 2027ZEKI AL HAZZOURI, ADINAreporter.nih.gov
Preeclampsia and the Brain: Small vessel disease and cognitive function in early midlifeNIHNational Institute on Aging2022 to 2025$3,960,160February 1, 2022November 30, 2026CATOV, JANET Mreporter.nih.gov
Burden and change in Alzheimers disease neuropathology in aging World Trade Center respondersNIHNational Institute on Aging2021 to 2025$3,952,934March 15, 2021February 28, 2027CLOUSTON, SEANreporter.nih.gov
Synergistic white matter injury from diesel exhaust particulate and chronic cerebral hypoperfusion exposures: Interaction between the Nogo/NgR1 receptor pathway and extravascular fibrinogen toxicityNIHNational Institute of Neurological Disorders and Stroke2022 to 2025$3,929,367September 20, 2022August 31, 2027MACK, WILLIAM Jreporter.nih.gov
Depression treatment and Aβ dynamics: A study of Alzheimer’s disease riskNIHNational Institute on Aging2021 to 2025$3,865,122August 15, 2021July 31, 2027POMARA, NUNZIOreporter.nih.gov
Validation of Imaging and Blood-based Small Vessel VCID Biomarkers in Multiethnic PopulationNIHNational Institute of Neurological Disorders and Stroke2023 to 2025$3,859,697September 30, 2021July 31, 2027WANG, DANNY JJreporter.nih.gov
PRE3BAD: Preclinical Research on Emerging Environmental Exposures, Brain Aging, and DementiaNIHNational Institute on Aging2024 to 2025$3,859,319September 30, 2024August 31, 2029CAMPEN, MATTHEW Jreporter.nih.gov
Perivascular fibroblasts, vascular fibrosis, and their contributions to cerebral amyloid angiopathyNIHNational Institute of Neurological Disorders and Stroke2022 to 2025$3,851,096September 19, 2022July 31, 2027LIPPMANN, ETHANreporter.nih.gov
Menopausal Vasomotor Symptoms and Brain Aging in WomenNIHNational Institute on Aging2021 to 2025$3,849,407August 15, 2016June 30, 2027THURSTON, REBECCA Creporter.nih.gov
Resilience to Cognitive Decline and Resistance to Alzheimer's Disease and Related Neurodegenerative Diseases in Individuals from Colombia with Autosomal Dominant DementiasNIHNational Institute of Neurological Disorders and Stroke2023$3,821,618August 15, 2023July 31, 2026QUIROZ, YAKEEL T.reporter.nih.gov
Alzheimer's Disease Pathology in a Primate ModelNIHNational Institute on Aging2021 to 2025$3,764,077February 15, 2021January 31, 2027HOPKINS, WILLIAM Dreporter.nih.gov
Digital Biomarkers for Vascular Cognitive Decline in Patients with Minor StrokeNIHNational Institute on Aging2022 to 2025$3,752,944September 10, 2022August 31, 2027MARSH, ELISABETH BREESEreporter.nih.gov
Neurocognition and Greater Maintenance of Sinus Rhythm in AF (NOGGIN AF)NIHNational Institute on Aging2021 to 2025$3,724,610September 1, 2021May 31, 2027MATHEW, JOSEPH Preporter.nih.gov
Digital Accessible Remote Olfactory Mediated Health Assessments forPreclinical ADNIHNational Institute on Aging2021 to 2025$3,718,193September 30, 2018June 30, 2027REINEKE, SEANreporter.nih.gov
TRP channels as fundamental sensors of the cerebral microcirculationNIHNational Heart, Lung, and Blood Institute2021 to 2024$3,709,945February 1, 2021July 31, 2024EARLEY, SCOTTreporter.nih.gov
Reducing African Americans' Alzheimer's Disease Risk Through Exercise-MCI Cohort (RAATE-MCI)NIHNational Institute on Aging2021 to 2025$3,689,143July 1, 2020March 31, 2027NEWTON, ROBERT LEEreporter.nih.gov
Lymphatics-Glymphatics in CNS Fluid HomeostasisNIHNational Center for Complementary & Integrative Health2021 to 2025$3,644,017April 1, 2021March 31, 2026BENVENISTE, HELENE Dreporter.nih.gov
Molecular and Physiological Mechanisms of Hypertensive Cerebral MicroangiopathyNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$3,627,088July 1, 2020April 30, 2026GUROL, MAHMUT EDIPreporter.nih.gov
Immunovascular interactions in postoperative delirium superimposed on dementia (DSD).NIHNational Institute on Aging2022 to 2025$3,624,866September 15, 2022August 31, 2027TERRANDO, NICCOLOreporter.nih.gov
Advanced MRI studies of cerebrovascular and lymphatic abnormalities in LRRK2 mouse models of Parkinson's diseaseNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$3,536,285April 1, 2021March 31, 2027SMITH, WANLI Wreporter.nih.gov
Assessing the Role of Sex-Specific Genetic Drivers of Cerebrovascular Disease in the Alzheimer's Disease BrainNIHNational Institute on Aging2025$3,531,593September 1, 2025August 31, 2029DUMITRESCU, LOGAN Creporter.nih.gov
SPRINT MIND 2020NIHNational Institute on Aging2021 to 2023$3,485,934June 15, 2017May 31, 2025REBOUSSIN, DAVID Mreporter.nih.gov
Longitudinal validation of cerebral small vessel disease biomarkers in diverse community-based older adults without dementiaNIHNational Institute of Neurological Disorders and Stroke2023 to 2025$3,480,622September 29, 2021July 31, 2027ARFANAKIS, KONSTANTINOSreporter.nih.gov
Construction of an Integrated Immune - Vascular Brain - Chip as a Platform for the Study, Drug Screening, and Treatments of Alzheimer's DiseaseNIHNational Institute of Neurological Disorders and Stroke2021 to 2023$3,475,569September 20, 2019May 31, 2024TSAI, LI-HUEIreporter.nih.gov
Role of Fibrinogen in Alzheimer's DiseaseNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$3,431,479April 1, 2018July 31, 2028STRICKLAND, SIDNEYreporter.nih.gov
The Role of PAI-1 in Cerebral Microvascular Dysfunction and the Development of Alzheimer’s Disease NeuropathologyNIHNational Institute on Aging2021 to 2025$3,397,256September 1, 2021June 30, 2027LAWRENCE, DANIEL Areporter.nih.gov
Metabolic and neural activity normalization by cerebral blood flow increase in AD/ADRD modelsNIHNational Institute on Aging2023 to 2025$3,391,148April 15, 2023January 31, 2028SCHAFFER, CHRIS Breporter.nih.gov
Sex Differences in Inflammation Across the LifespanNIHNational Institute of Neurological Disorders and Stroke2023 to 2025$3,353,112May 1, 2023April 30, 2031MCCULLOUGH, LOUISE D.reporter.nih.gov
BRain Aging and Cognition in Epilepsy (BRACE): A longitudinal investigation of vascular, genetic, and biomarker risk profiles in elderly patients with epilepsyNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$3,346,371September 1, 2021February 28, 2027MCDONALD, CARRIE Rreporter.nih.gov
Multiethnic Validation of VCID Biomarkers in South TexasNIHNational Institute of Neurological Disorders and Stroke2023 to 2025$3,325,938September 30, 2021July 31, 2027SATIZABAL, CLAUDIA Lreporter.nih.gov
Locus Coeruleus Imaging Markers in Preclinical Alzheimers disease, Cerebrovascular Disease and Cognitive DeclineNIHNational Institute on Aging2024 to 2025$3,322,482April 1, 2023March 31, 2029NATION, DANIEL Areporter.nih.gov
Innate Immunity Stimulation Effects on Biomarkers, Cognition, and the Vascular Amyloid Proteome in a Squirrel Monkey Model of Sporadic CAANIHNational Institute of Neurological Disorders and Stroke2022 to 2025$3,321,272July 15, 2022June 30, 2027SCHOLTZOVA, HENRIETAreporter.nih.gov
Brain Effects of Lifetime Racial/Ethnic Discrimination on the LC-NE Function and the Risk for Alzheimer's DiseaseNIHNational Institute on Aging2021 to 2024$3,312,473September 5, 2021June 30, 2026DING, YU-SHINreporter.nih.gov
Low Neurophysiologic Resistance to Anesthetics as a Marker of Preclinical/Prodromal Alzheimer's Disease and Neurovascular Pathology, Delirium risk and InattentionNIHNational Institute on Aging2022 to 2025$3,308,332August 1, 2022April 30, 2027DEVINNEY, MICHAEL JOSEPHreporter.nih.gov
Role of GPR39 in Aging-Related Vascular Cognitive Impairment (VCI)NIHNational Institute on Aging2022 to 2025$3,287,439September 15, 2022August 31, 2027ALKAYED, NABIL Jreporter.nih.gov
Microglia-Amyloid interactions in delirium superimposed on dementiaNIHNational Institute on Aging2021 to 2025$3,246,663September 15, 2017December 31, 2027TERRANDO, NICCOLOreporter.nih.gov
Role of endothelium in pathogenesis of cerebral amyloid angiopathyNIHNational Institute on Aging2021 to 2025$3,245,352September 1, 2021June 30, 2026KATUSIC, ZVONIMIR Sreporter.nih.gov
ApoE4, Neurovascular Injury and Cognitive ImpairmentNIHNational Institute of Neurological Disorders and Stroke2022 to 2025$3,244,519April 1, 2022March 31, 2027IADECOLA, COSTANTINOreporter.nih.gov
Cerebral hemodynamic impairment in symptomatic and asymptomatic Alzheimer's DiseaseNIHNational Institute on Aging2022 to 2025$3,221,061February 1, 2022January 31, 2027QIU, DEQIANGreporter.nih.gov
Vascular contribution to white matter lesions and motor dysfunction in AD and ADRDNIHNational Institute on Aging2022 to 2025$3,210,645September 15, 2022August 31, 2027AHN, HYUNG JINreporter.nih.gov
RCT Targeting Cognition in Early Alzheimer's Disease by Improving Sleep with Trazodone (Rest)NIHNational Institute on Aging2021 to 2024$3,203,115September 15, 2021August 31, 2026GREENBERG, BARRY DAVIDreporter.nih.gov
Characterization of relationship between tau pathology and neurodegeneration in Alzheimer's disease using multimodal imagingNIHNational Institute on Aging2022 to 2025$3,200,041April 15, 2022January 31, 2027DAS, SANDHITSUreporter.nih.gov
Effects of vascular risk factors on risk for dementia and stroke after late-onset epilepsy (EpilepsyCOG)NIHNational Institute on Aging2022 to 2025$3,188,533July 1, 2022March 31, 2027CHOI, HYUNMIreporter.nih.gov
Novel Imaging and Biofluid Biomarkers of Small Vessel Cerebrovascular DiseaseNIHNational Institute of Neurological Disorders and Stroke2023 to 2025$3,180,774September 29, 2021July 31, 2027KRAMER, JOEL Hreporter.nih.gov
Cerebrovascular Remodeling and Neurodegenerative Changes in Alzheimer's DiseaseNIHNational Institute on Aging2022 to 2025$3,178,600February 1, 2022January 31, 2027ZHANG, YANHANG KATHERINEreporter.nih.gov
Contributions of modifiable physical attributes to cognitive and brain agingNIHNational Institute on Aging2021 to 2025$3,167,967May 15, 2021April 30, 2027HAYES, SCOTT Mreporter.nih.gov
Carotid Revascularization and Medical Management for Asymptomatic CarotidStenosis Trial - Hemodynamics (CREST-H)NIHNational Institute of Neurological Disorders and Stroke2021 to 2025$3,153,445May 15, 2017July 31, 2027MARSHALL, RANDOLPH Sreporter.nih.gov
POINTER-zzz: Sleep Ancillary to U.S. Study to Protect Brain Health through Lifestyle Intervention to Reduce Risk of Alzheimer's DiseaseNIHNational Institute on Aging2021 to 2023$3,144,541August 15, 2019May 31, 2025BAKER, LAURA D.reporter.nih.gov
Role of vascular KATP channels in Alzheimer’s neurodegeneration and dementiaNIHNational Heart, Lung, and Blood Institute2021 to 2023$3,134,584January 1, 2018December 31, 2023NICHOLS, COLIN Greporter.nih.gov
Investigating Resistance and Resilience Mechanisms in Alzheimer’s DiseaseNIHNational Institute on Aging2021 to 2025$3,131,976September 15, 2017February 29, 2028VEMURI, PRASHANTHIreporter.nih.gov
Alzheimer's Abeta, Tau, Apolipoproteins and Blood-brain barrierNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$3,119,037September 1, 1995February 28, 2026YASSINE, HUSSEIN Nreporter.nih.gov
Longitudinal MRI Investigation of Traumatic Microvascular InjuryNIHNational Institute of Neurological Disorders and Stroke2022 to 2025$3,116,729February 15, 2022January 31, 2027WARE, JEFFREY Breporter.nih.gov
Impairment of Ischemia-induced Vascular Functions by PS1 FAD MutantsNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$3,116,100January 15, 2021December 31, 2025GEORGAKOPOULOS, ANASTASIOSreporter.nih.gov
Alzheimer's Disease Hallmark Pathology and Associated Inflammation in the RetinaNIHNational Institute on Aging2021 to 2025$3,113,565April 1, 2018June 30, 2028KORONYO-HAMAOUI, MAYAreporter.nih.gov
Recovery of StrokE - Longitudinal Assessment With Neuroimaging (ROSE LAWN)NIHNational Institute of Neurological Disorders and Stroke2021 to 2024$3,104,674December 15, 2020November 30, 2025WOO, DANIELreporter.nih.gov
Advanced MR Imaging of Olfactory Impairment in Prodromal Alzheimer's DiseaseNIHNational Institute on Aging2021 to 2024$3,102,717May 1, 2020February 28, 2026HUA, JUNreporter.nih.gov
Immune Cells in Alzheimer’s Disease and Related Dementias in the Jackson Heart StudyNIHNational Institute on Aging2022 to 2025$3,079,808March 1, 2022November 30, 2026RAFFIELD, LAURA Mreporter.nih.gov
Covert Cerebrovascular Disease Detected by Artificial Intelligence (C2D2AI): A Platform for Pragmatic Evidence Generation for Stroke and Dementia PreventionNIHNational Institute of Neurological Disorders and Stroke2023 to 2025$3,076,281February 1, 2023January 31, 2026KENT, DAVID Mreporter.nih.gov
Novel Volumetric Optical Microscopy to Unravel Cerebral Microvascular Architecture and the Role in Functional Neuroimaging in Human Alzheimer's DiseaseNIHNational Institute of Neurological Disorders and Stroke2022 to 2025$3,069,316August 1, 2022July 31, 2027WANG, HUIreporter.nih.gov
Efflux Route Responses of Cerebral Waste Clearance During Progression of Alzheimer’s DiseaseNIHNational Institute on Aging2025$3,062,355September 15, 2025August 31, 2029JIANG, QUANreporter.nih.gov
The Amylin Dyshomeostasis Hypothesis of Vascular Contributions to Cognitive Impairment and Dementia (VCID)NIHNational Institute of Neurological Disorders and Stroke2021 to 2024$3,056,084April 1, 2020March 31, 2026DESPA, FLORINreporter.nih.gov
Intracranial arterial compliance, cerebral blood flow, and dementia risk in older adults with type 2 diabetesNIHNational Institute on Aging2021 to 2024$3,038,302May 1, 2020February 28, 2026BANGEN, KATHERINEreporter.nih.gov
Aging Research Characterizing Health Equity via Social determinants (ARCHES)NIHNational Institute on Aging2021 to 2024$3,033,223September 1, 2021May 31, 2026BABULAL, GANESH Mreporter.nih.gov
Noninvasive sensory stimulation to promote glymphatic-lymphatic clearance for the treatment of Alzheimer’s DiseaseNIHNational Center for Complementary & Integrative Health2021 to 2025$3,032,391May 15, 2021April 30, 2026TSAI, LI-HUEIreporter.nih.gov
Gas-free cerebrovascular reactivity (CVR) MRI in vascular cognitive impairmentNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$2,984,490August 16, 2021July 31, 2027LIU, PEIYINGreporter.nih.gov
Safety and Tolerability Studies for an Anti-Fibrin P2 Monoclonal Antibody for the Treatment of Alzheimer's DiseaseNIHNational Institute on Aging2021 to 2023$2,970,786September 30, 2021August 31, 2024KANTOR, AARON Breporter.nih.gov
Dementia prevalence, APOE, and blood-based biomarkers of AD in Native American communitiesNIHNational Institute on Aging2022 to 2025$2,961,521August 15, 2022April 30, 2027MANTYH, WILLIAM Greporter.nih.gov
Air pollution and early signs of dementiaNIHNational Institute on Aging2022 to 2025$2,959,713September 30, 2022August 31, 2027HUELS, ANKEreporter.nih.gov
Brain signature of SARS-CoV-2 Infection and its impact on long-term cognitive functioning in older adultsNIHNational Institute on Aging2022 to 2025$2,954,828July 1, 2022June 30, 2027SCHIFITTO, GIOVANNIreporter.nih.gov
Development and Evaluation of Portable Compendium of Psychophysical and Physiological Tests for Alzheimer's Disease and Related Dementias (ADRD)NIHNational Institute on Aging2023 to 2025$2,947,375August 1, 2023April 30, 2026NWAOKOBIA, CHARLES CHIEDUreporter.nih.gov
Global Brain Health Predictors of Post-Stroke Sensorimotor Recovery using AI-Enhanced Clinical MRIsNIHNational Institute of Neurological Disorders and Stroke2025$2,942,690April 1, 2020June 30, 2029LIEW, SOOK-LEIreporter.nih.gov
Stroke Connectome MRI Biomarkers for VCID Risk AssessmentNIHNational Institute of Neurological Disorders and Stroke2022 to 2025$2,928,784April 1, 2022March 31, 2027NAIR, VEENA Areporter.nih.gov
Longitudinal multi-omic biomarkers for neurocognitive decline prior to dementia onsetNIHNational Institute on Aging2024 to 2025$2,904,500September 30, 2024June 30, 2029HARRIS, SARAH ELIZABETHreporter.nih.gov
Dietary Sodium, Neurovascular Dysfunction and Cerebrovascular RiskNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$2,895,400December 1, 2015June 30, 2027IADECOLA, COSTANTINOreporter.nih.gov
Roles of Gray Matter Brain Aging and Small Vessel Disease in AD PathophysiologyNIHNational Institute on Aging2024 to 2025$2,872,909March 1, 2005February 28, 2027AIZENSTEIN, HOWARD Jreporter.nih.gov
Multiethnic machine learning brain signatures of ADRDNIHNational Institute on Aging2022 to 2025$2,860,890September 1, 2022June 30, 2027HABES, MOHAMADreporter.nih.gov
Elucidating Molecular Drivers of Aging and Alzheimer's Disease via Multimodal Imaging Mass SpectrometryNIHNational Institute on Aging2022 to 2025$2,856,050September 1, 2022June 30, 2027SPRAGGINS, JEFFREY Mreporter.nih.gov
Auracle: An AI-Enabled Telecare System to Support the Independence and Safety of Individuals with AD/ADRD and Other DementiasNIHNational Institute on Aging2021 to 2023$2,851,310September 1, 2021August 31, 2025FAUCI, MARK Areporter.nih.gov
The relationship between ocus-coeruleus-norepinephrine network and neurovascular coupling in health and diseaseNIHNational Institute of Neurological Disorders and Stroke2025$2,813,759August 15, 2025July 31, 2029TRAN, CAM HA THAIreporter.nih.gov
An Epidemiologic Study of Disparities in Sleep and Cognition in Older Adults (DISCO)NIHNational Institute on Aging2021 to 2023$2,797,984July 1, 2019March 31, 2024KNUTSON, KRISTENreporter.nih.gov
Pathological mechanisms of white matter hyperintensitiesNIHNational Institute on Aging2021 to 2024$2,796,704September 1, 2021January 15, 2025RANE LEVENDOVSZKY, SWATIreporter.nih.gov
Modeling and Therapeutic Approaches for Genetic VasculopathiesNIHNational Institute of Neurological Disorders and Stroke2022 to 2025$2,784,876September 20, 2022July 31, 2027MUSOLINO, PATRICIA Lreporter.nih.gov
Investigating the Microvascular Mechanisms of O2 Supply-Demand Mismatch in Small Vessel Disease using Novel High-Resolution Optical ImagingNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$2,778,545May 1, 2020April 30, 2026SAKADZIC, SAVAreporter.nih.gov
BBB Dysfunction in Post-Stroke DementiaNIHNational Institute of Neurological Disorders and Stroke2022 to 2025$2,776,180September 15, 2022August 31, 2027BUCKWALTER, MARION Sreporter.nih.gov
Favorable cardiovascular health, connectome integrity, and ADRD clinical outcomes and pathologic underpinnings in a diverse cohort.NIHNational Institute on Aging2022 to 2025$2,728,963August 1, 2022July 31, 2028LAMAR, MELISSAreporter.nih.gov
Metabolic and Vascular Factors in tau pathogenesisNIHNational Institute on Aging2021 to 2024$2,720,466September 15, 2020May 31, 2025FRAUTSCHY, SALLY ANNreporter.nih.gov
Metabolic and Hormonal Mechanisms of VCIDNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$2,707,906April 15, 2019August 31, 2029ZULOAGA, KRISTEN LEANNEreporter.nih.gov
Role of Endothelial K+ Channels in Age-Related DementiaNIHNational Institute on Aging2022 to 2025$2,707,384May 1, 2022April 30, 2027BEHRINGER, ERIK J.reporter.nih.gov
Establishment of a Human Microphysiological System to Elucidate Cellular Mechanisms Underlying Vulnerability to ADNIHNational Institute of Neurological Disorders and Stroke2025$2,683,965May 1, 2025April 30, 2028YOUNG-PEARSE, TRACY Lreporter.nih.gov
Enhancing gamma band response to improve working memory in individuals with mild cognitive impairmentNIHNational Institute on Aging2021 to 2024$2,658,625April 1, 2020March 31, 2026SINGH, FIZAreporter.nih.gov
Underlying Mechanisms in CADASILNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,643,847April 20, 2021March 31, 2026IRUELA-ARISPE, M. LUISAreporter.nih.gov
24-hour Activity Cycles to Optimize Cognitive Resilience to Alzheimer's Disease in African Americans: The Jackson Heart StudyNIHNational Institute on Aging2021 to 2023$2,629,362September 15, 2020May 31, 2026GABRIEL, KELLEY PETTEEreporter.nih.gov
Development and validation of novel models for cerebral small vessel disease and vascular cognitive impairmentNIHNational Institute of Neurological Disorders and Stroke2021 to 2023$2,624,637September 18, 2019August 31, 2025GOULD, DOUGLASreporter.nih.gov
Diversity Supplement for Jenny LutshumbaNIHNational Institute on Aging2023 to 2024$2,600,455September 1, 2023August 31, 2026STOWE, ANN MARIEreporter.nih.gov
Cerebral Microvascular Signaling and Neurovascular Coupling: An Integrated Approach to Investigate VCIDNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$2,597,866August 1, 2021June 30, 2026TSOUKIAS, NIKOLAOS MICHAELreporter.nih.gov
Sex differences in the contribution of cerebrovascular injury and immune activation to neurocognitive impairment in HIV infectionNIHNational Institute of Neurological Disorders and Stroke2022 to 2025$2,594,711May 15, 2022February 28, 2027CHOW, FELICIA C.reporter.nih.gov
Role of Peripheral Immune Cells in Cognitive Aging: The Framingham Offspring StudyNIHNational Institute on Aging2021 to 2024$2,594,669April 15, 2020March 31, 2026MURABITO, JOANNE Mreporter.nih.gov
Human 3D Neuro-Vascular Interaction and Meningeal Lymphatic Models with Application to Alzheimer’s DiseaseNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$2,593,927May 1, 2021April 30, 2026KAMM, ROGER Dreporter.nih.gov
Blood-Brain Barrier Disruption as a Biomarker for Perioperative Neurocognitive Disorder:Cognitive Recovery after Elective SurgeryNIHNational Institute on Aging2021 to 2024$2,592,630May 1, 2019February 28, 2026DAIELLO, LORI Areporter.nih.gov
Using AI on Routine Clinical and Imaging Data from Acute Stroke Encounter to Predict Post-Stroke Vascular Contributions to Cognitive Impairment (AI - RESPECT)NIHNational Institute of Neurological Disorders and Stroke2024 to 2025$2,575,013September 1, 2024July 31, 2027HU, XIAOreporter.nih.gov
Investigating the Role and the therapeutic potential of Perlecan in experimental vascular dementiaNIHNational Institute of Neurological Disorders and Stroke2024$2,573,724June 12, 2024April 30, 2027BIX, GREGORY JAYEreporter.nih.gov
Transferring Speed of Processing Gains to Everyday Cognitive Tasks after StrokeNIHNational Institute on Aging2021 to 2024$2,570,286September 5, 2021August 31, 2025USWATTE, GITENDRAreporter.nih.gov
Pericyte control of capillary perfusion in the Alzheimer's disease brainNIHNational Institute on Aging2023 to 2025$2,557,000April 15, 2023January 31, 2028SHIH, ANDY Yreporter.nih.gov
Neuropathology and inflammation in a nonhuman primate model of insulin resistance/metabolic syndromeNIHNational Institute on Aging2024 to 2025$2,556,565February 15, 2024November 30, 2028HAVEL, PETER Jreporter.nih.gov
Impact of SARS-CoV-2 on the cerebrovasculature as a risk factor for VCID: Role of Wnt/beta-cateninNIHNational Institute of Neurological Disorders and Stroke2025$2,549,080August 11, 2025July 31, 2029LUTZ, SARAH ELIZABETHreporter.nih.gov
Citalopram as a posterior cortical protective therapy in Parkinson diseaseNIHNational Institute on Aging2021 to 2024$2,545,093August 15, 2020April 30, 2026KOTAGAL, VIKASreporter.nih.gov
Non-Invasive Imaging Markers to Elicit the Role of Vascular Involvement in Alzheimer’s DiseaseNIHNational Institute on Aging2022 to 2025$2,534,541February 15, 2022January 31, 2027JOHNSON, KEVIN MICHAELreporter.nih.gov
The role of brain border-associated macrophages in aging and cerebral amyloid angiopathyNIHNational Institute on Aging2022 to 2025$2,534,516January 15, 2022December 31, 2026LAFAILLE, JUANreporter.nih.gov
BRAIN HEALTH TOGETHER: A LIVE-STREAMING GROUP-BASED DIGITAL PROGRAMNIHNational Institute on Aging2021 to 2023$2,534,108September 30, 2021November 30, 2024BENJAMIN, CYNTHIA LOUISEreporter.nih.gov
Effects of NAD restoration on neurovascular coupling in community dwelling older adultsNIHNational Institute on Aging2022 to 2025$2,531,921August 15, 2022April 30, 2027YABLUCHANSKIY, ANDRIYreporter.nih.gov
Activated protein C mechanisms of brain white matter protection and new therapies for brain white matter ischemic injuryNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$2,531,008July 15, 2020April 30, 2026MACK, WILLIAM Jreporter.nih.gov
Vascular Contributions to Cognitive Impairment after Adverse Pregnancy Outcomes: the nuMoM2b-Heart Health StudyNIHNational Institute of Neurological Disorders and Stroke2021 to 2023$2,523,397July 15, 2021June 30, 2027MILLER, ELIZA Creporter.nih.gov
Sex-specific cognitive expression and risk in preclinical Alzheimer's diseaseNIHNational Institute on Aging2021 to 2023$2,519,693September 15, 2019May 31, 2025BANKS, SARAHreporter.nih.gov
Effects of global brain health on sensorimotor recovery after strokeNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$2,507,791April 1, 2020March 31, 2026LIEW, SOOK-LEIreporter.nih.gov
Use of Healthcare Across the Full Continuum of Cognitive Health and Decline in Older AdultsNIHNational Institute on Aging2022 to 2025$2,505,518September 30, 2022June 30, 2027GRODSTEIN, FRANCINEreporter.nih.gov
Global Blood-Brain Barrier Disruption and Post-Stroke Cognitive DeclineNIHNational Institute of Neurological Disorders and Stroke2022 to 2025$2,499,958April 1, 2022August 31, 2027LEIGH, RICHARDreporter.nih.gov
Early Detection of Mild Cognitive Impairment, Alzheimer's Disease and Other Dementias using EHRNIHNational Institute on Aging2021 to 2025$2,490,121September 15, 2020May 31, 2027SOHN, SUNGHWANreporter.nih.gov
Imaging Cerebral Small Vessels in Vascular Cognitive Impairment and Dementia (VCID)NIHNational Institute on Aging2023$2,487,668September 1, 2023August 31, 2026WANG, DANNY JJreporter.nih.gov
Gene therapy for disorders of the extracellular matrixNIHNational Institute of Neurological Disorders and Stroke2023$2,481,348April 1, 2023March 31, 2026GOULD, DOUGLASreporter.nih.gov
Reducing African Americans' Alzheimer's Disease Risk Through Exercise (RAATE)NIHNational Institute on Aging2021 to 2025$2,465,845February 15, 2019November 30, 2025NEWTON, ROBERT LEEreporter.nih.gov
Leveraging Electronic Health Records and artificial IntelligeNce to improve Dementia Screening and early Detection in primary care (LEARN-DSD)NIHNational Institute on Aging2023 to 2025$2,462,815September 21, 2023July 31, 2028RAZAVIAN, NARGESreporter.nih.gov
Brain lymphatic activation for craniosynostosis and Alzheimer’s diseaseNIHNational Institute of Neurological Disorders and Stroke2024$2,461,369June 1, 2024May 31, 2027CHEN, JIANFUreporter.nih.gov
Angiogenic Therapy: Novel Approaches to Enhance Bone Regeneration in Aging - AD/ADRDNIHNational Institute on Aging2021 to 2023$2,458,774April 1, 2019January 31, 2025KACENA, MELISSA Areporter.nih.gov
Velocity-Selective Arterial Spin Labeling based Perfusion Mapping for Alzheimer's diseaseNIHNational Institute on Aging2023$2,448,470May 1, 2023April 30, 2026QIN, QINreporter.nih.gov
Vascular contributions to HIV-associated Neurocognitive Disorders (HAND)NIHNational Institute on Aging2022 to 2024$2,441,402August 1, 2022July 31, 2027GUTIERREZ, JOSEreporter.nih.gov
Development of perivascular space mapping toolset as a diagnostic aid for Alzheimer's diseaseNIHNational Institute on Aging2024 to 2025$2,439,170August 1, 2024July 31, 2027CHOUPAN, JEIRANreporter.nih.gov
Role of Microglia in Cerebral Small Vessel Disease (CSVD)/Vascular Cognitive Impairment (VCI)NIHNational Institute of Neurological Disorders and Stroke2022 to 2025$2,430,570July 15, 2022June 30, 2027WEINSTEIN, JONATHAN Rreporter.nih.gov
Revitalizing Cognition in Older Adults at Risk for Alzheimer's Disease with Near-Infrared PhotobiomodulationNIHNational Institute on Aging2021 to 2023$2,427,515August 1, 2019April 30, 2026BOWERS, DAWNreporter.nih.gov
Inspiring Healthy Engagement and Learning for Vascular Dementia (I-HEAL)NIHNational Institute of Neurological Disorders and Stroke2025$2,421,629September 1, 2025August 31, 2029CABAN-HOLT, ALLISON MERCEDESreporter.nih.gov
Human cerebral blood flow regulation: sex, mechanism, and stress differencesNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,414,516June 1, 2020May 31, 2025SCHRAGE, WILLIAM Greporter.nih.gov
REACH-EpiVCIDNIHNational Institute of Neurological Disorders and Stroke2024$2,403,545August 5, 2024July 31, 2027ANDERSON, CHRISTOPHER DAVIDreporter.nih.gov
Mechanisms of APOE-Induced Preclinical Alzheimer's Pathophysiology in Human Olfactory SystemNIHNational Institute on Aging2021 to 2023$2,398,805August 15, 2019May 31, 2025NWULIA, EVARISTUS Areporter.nih.gov
Brain capillary endothelial cell energetics and neurovascular uncoupling in dementiaNIHNational Institute of Neurological Disorders and Stroke2024$2,398,590September 24, 2024August 31, 2026DABERTRAND, FABRICEreporter.nih.gov
Role of TREX1 in age-related hereditary leukoencephalopathyNIHNational Institute of Neurological Disorders and Stroke2023 to 2025$2,381,292September 20, 2023June 30, 2028MINER, JONATHAN Jreporter.nih.gov
Type 2 Diabetes Mellitus and Vascular Contributions to Cognitive Impairment and Dementia (T2DM-VCID)NIHNational Institute of Neurological Disorders and Stroke2024$2,380,018September 18, 2024August 31, 2027LEVINE, DEBORAH ALLISONreporter.nih.gov
Mechanisms of Vasomotion-mediated Perivascular Clearance in Cerebral Amyloid AngiopathyNIHNational Institute of Neurological Disorders and Stroke2022 to 2025$2,376,712August 1, 2022July 31, 2027GREENBERG, STEVEN Mreporter.nih.gov
Alzheimer Pathology and Neurovascular DysfunctionNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$2,375,220July 1, 1998December 31, 2027IADECOLA, COSTANTINOreporter.nih.gov
Genetic and Environmental Risk Factors for Hemorrhagic Stroke – VNIHNational Institute of Neurological Disorders and Stroke2024$2,374,719September 12, 1997July 31, 2027WOO, DANIELreporter.nih.gov
Investigating the role of Alpha5Beta1 integrin in cognitive dysfunctionNIHNational Institute on Aging2023 to 2024$2,373,215April 1, 2023March 31, 2026BIX, GREGORY JAYEreporter.nih.gov
Identifying A Skeleton-Derived Factor for Vascular AgingNIHNational Institute on Aging2021 to 2025$2,368,758April 1, 2021December 31, 2026WAN, MEIreporter.nih.gov
Epigenetic Aging Cognitive Function and Exercise in Older AdultsNIHNational Institute on Aging2024$2,358,537September 1, 2024August 31, 2027CONLEY, YVETTE Preporter.nih.gov
SPAK-NKCC1 complex and the blood-CSF barrier dysregulation in VCIDNIHNational Institute of Neurological Disorders and Stroke2025$2,353,206September 8, 2025June 30, 2029SUN, DANDANreporter.nih.gov
CSF Clearance in Sporadic Alzheimer's DiseaseNIHNational Institute on Aging2021 to 2023$2,348,572August 15, 2019April 30, 2025LI, YIreporter.nih.gov
Imaging of cerebral microvascular pulsatility in cerebral small vessel diseaseNIHNational Institute of Neurological Disorders and Stroke2024$2,346,270August 1, 2024June 30, 2027YAN, LIRONGreporter.nih.gov
Adverse Cerebrovascular Responses to Antibodies Targeting Beta-AmyloidNIHNational Institute of Neurological Disorders and Stroke2024$2,342,415June 1, 2024May 31, 2027CRIBBS, DAVID HASTINGSreporter.nih.gov
COVID-19-related blood-brain barrier and microstructural brain injury; Sex differences and synergy with Alzheimer's disease riskNIHNational Institute on Aging2023 to 2025$2,337,162December 15, 2022November 30, 2027REAS, EMILIE T.reporter.nih.gov
Common mechanistic biomarkers of vascular and neuro-degenerationNIHNational Institute on Aging2023 to 2025$2,330,263January 1, 2023December 31, 2027LIU, YONGMEIreporter.nih.gov
Building a Platform for Precision Anesthesia for the Geriatric Surgical PatientNIHNational Institute on Aging2022 to 2024$2,319,904September 1, 2020August 31, 2025DROVER, DAVID RAYMONDreporter.nih.gov
Map Paravascular Fluid Dynamic Signatures of Key Aging and AD Processes Using Dynamics Diffusion-Weighted ImagingNIHNational Institute on Aging2023$2,317,887September 15, 2023August 31, 2026WEN, QIUTINGreporter.nih.gov
CAPSTONE: Central And Peripheral STrOke inflammatioN with ExosomesNIHNational Institute of Neurological Disorders and Stroke2022 to 2024$2,297,999July 19, 2022June 30, 2027WALSH, KYLE BRENDANreporter.nih.gov
Investigating and targeting apolipoprotein E4 in Down syndrome-associated Alzheimer's diseaseNIHNational Institute on Aging2023$2,282,487July 15, 2023June 30, 2026JOHNSON, NOAH RAYreporter.nih.gov
The effect of circadian rhythm disruptions on the angiogenic response to hypoperfusion in the AD brainNIHNational Institute on Aging2023 to 2025$2,278,875May 1, 2023January 31, 2028ARAI, KENreporter.nih.gov
Simultaneous EEG/fMRI to disentangle neural and vascular mechanisms of Alzheimer's disease pathologyNIHNational Institute on Aging2022 to 2025$2,274,229August 15, 2022July 31, 2027SITNIKOVA, TATIANAreporter.nih.gov
Role of cerebral vasculature in brain ischemia in HIV infectionNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,266,377September 15, 2014July 31, 2026TOBOREK, MICHALreporter.nih.gov
Exercise Mimetics for Dementia and Alzheimer's DiseaseNIHNational Institute on Aging2023$2,262,938February 1, 2023January 31, 2026BURRIS, THOMAS Preporter.nih.gov
Elucidating microvascular contributions to cognitive impairment at single-cell resolutionNIHNational Institute of Neurological Disorders and Stroke2023 to 2025$2,262,548December 3, 2024June 30, 2028YANG, ANDREW CHRISreporter.nih.gov
Reproductive history and later-life brain health: The Bogalusa Heart StudyNIHNational Institute on Aging2023$2,258,605September 1, 2023August 31, 2026HARVILLE, EMILY WHEELERreporter.nih.gov
Midlife cardiovascular stress physiology and preclinical cerebrovascular diseaseNIHNational Heart, Lung, and Blood Institute2023 to 2025$2,248,100July 1, 2023June 30, 2028GIANAROS, PETER Jreporter.nih.gov
GPR39 as a Therapeutic Target in Aging-Related Vascular Cognitive Impairment and DementiaNIHNational Institute on Aging2023$2,244,471September 1, 2023August 31, 2026ALKAYED, NABIL Jreporter.nih.gov
Diversity Supplement to 1RF1 NS128963NIHNational Institute of Neurological Disorders and Stroke2022 to 2023$2,240,090August 15, 2022June 30, 2025NELSON, MARK Treporter.nih.gov
Neurological and digital correlates of cognition in Older Mandarin-speaking AdultsNIHNational Institute on Aging2023$2,236,070December 15, 2022November 30, 2025HU, WILLIAM TZU-LUNGreporter.nih.gov
Identification of plasma lipoprotein proteins and lipids as biomarkers of innate-immunity and vascular contributions to Alzheimer's disease and Alzheimer's disease-related dementias in older adultsNIHNational Institute on Aging2023$2,232,476June 1, 2023May 31, 2026LI, DANNIreporter.nih.gov
Transcranial Magnetic Stimulation for MCI: A Phase II Dose-Response StudyNIHNational Institute on Aging2023 to 2025$2,230,431May 15, 2023April 30, 2028BENITEZ, ANDREANAreporter.nih.gov
Novel Biomarkers of Small Vessel Contributions to Vascular Cognitive Impairment and Dementia (VCID)NIHNational Institute of Neurological Disorders and Stroke2021 to 2023$2,230,406August 15, 2019June 30, 2025DETRE, JOHN Areporter.nih.gov
Imaging Advancements in Small Vessel and CSF Flow Pathophysiology of Pre-clinical Alzheimer's DiseaseNIHNational Institute on Aging2021 to 2023$2,224,084April 15, 2019January 31, 2026IBRAHIM, TAMER Sreporter.nih.gov
Identifying the Genetic Etiology of Neuropathology for Alzheimer Disease and Related DementiasNIHNational Institute on Aging2021 to 2023$2,223,810June 15, 2019March 31, 2026BEECHAM, GARY WAYNEreporter.nih.gov
Adaptive Neuromodulation of Working Memory Networks in Aging and DementiaNIHNational Institute on Aging2022 to 2024$2,223,690September 15, 2022May 31, 2027DAVIS, SIMON Wreporter.nih.gov
An Imaging Repository for the Cerebrovascular Disease Knowledge Portal (iCDKP)NIHNational Institute of Neurological Disorders and Stroke2023 to 2025$2,195,574September 1, 2023August 31, 2028ROSAND, JONATHANreporter.nih.gov
Glymphatic impairment as a crucial factor in particulate matter exposure related development of Alzheimer's disease pathologyNIHNational Institute on Aging2023 to 2025$2,180,411September 1, 2023May 31, 2028HUSSAIN, RASHADreporter.nih.gov
Early Detection of Vascular Dysfunction Using Biomarkers from Lagrangian Carotid Strain ImagingNIHNational Heart, Lung, and Blood Institute2021 to 2023$2,172,540July 15, 2020June 30, 2025VARGHESE, TOMYreporter.nih.gov
IL-6 Trans-signaling increases vulnerability to Postoperative Cognitive Decline in Aging and Alzheimers DiseaseNIHNational Institute on Aging2024 to 2025$2,167,099September 15, 2024May 31, 2029MAZE, MERVYNreporter.nih.gov
The role of blood and brain 5-hydroxymethylcytosine in linking vascular risk factors to ADRD in older White and Black personsNIHNational Institute on Aging2024 to 2025$2,159,342August 15, 2021July 31, 2027ARVANITAKIS, ZOEreporter.nih.gov
Fine particulate matter exposure and small cerebrovascular inflammationNIHNational Institute of Neurological Disorders and Stroke2023$2,151,314September 19, 2023August 31, 2026LIU, ZHENGUOreporter.nih.gov
Elucidating the Role of Endothelial Dysfunction in Alzheimer Disease: Towards A New Data-Driven Disease ModelNIHNational Institute on Aging2023$2,140,130September 1, 2023August 31, 2026TARAWNEH, RAWANreporter.nih.gov
Metabolic Interventions for Sleep, Anesthesia-related Neurocognitive Disorders and Alzheimer's DiseaseNIHNational Institute on Aging2022 to 2025$2,137,648June 15, 2022February 28, 2027NEHS, CHRISTA JOYreporter.nih.gov
Neurovascular Consequences of Non-Pulsatile Flow from Left Ventricular Assist DevicesNIHNational Institute of Neurological Disorders and Stroke2022 to 2025$2,135,855January 1, 2022December 31, 2026WILLEY, JOSHUA ZEBADIAHreporter.nih.gov
Post-stroke normal appearing white matter diffusion properties and cognitive trajectories across ageNIHNational Institute of Neurological Disorders and Stroke2023 to 2025$2,126,325February 1, 2023January 31, 2028INGO, CARSON Jreporter.nih.gov
Cerebrospinal fluid exchange in Alzheimer's disease characterized by advanced MRI techniquesNIHNational Institute on Aging2023 to 2025$2,119,671December 15, 2022November 30, 2027XU, JIADIreporter.nih.gov
Contribution of Cerebral Iron Load to Cognitive Function in Older Adults with High Risk to Develop Alzheimer's DiseaseNIHNational Institute on Aging2021 to 2024$2,115,944September 15, 2020May 31, 2026QIAO, YEreporter.nih.gov
Early Life Cardiovascular Disease Risk Factors, Epigenetic Age Acceleration, and Alzheimer's Disease Related Brain HealthNIHNational Institute on Aging2023 to 2025$2,111,649April 1, 2022January 31, 2027KELLY, TANIKA NICOLEreporter.nih.gov
AQP4 and glymphatic function in post-stroke recoveryNIHNational Institute of Neurological Disorders and Stroke2022 to 2024$2,108,706July 1, 2022June 30, 2027YU, XINreporter.nih.gov
Investigating Pathways from Adverse Pregnancy Outcomes to Alzheimer's Disease and Related Dementias: the nuMoM2b-Brain StudyNIHNational Institute on Aging2024$2,090,311July 15, 2024February 28, 2025MILLER, ELIZA Creporter.nih.gov
Dementia Risk Prediction Pooling ProjectNIHNational Institute of Neurological Disorders and Stroke2022 to 2024$2,083,833September 30, 2020August 31, 2025ALLEN, NORRINA BAIreporter.nih.gov
Psychosocial Stress-Induced Vascular Contributions To Cognitive Impairment And Alzheimer's Disease: The Role of Xanthine OxidaseNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$2,079,585September 1, 2021July 31, 2025CHANTLER, PAUL Dreporter.nih.gov
Ex Vivo Imaging of the Aging Brain to Discover Morphology/Pathology AssociationsNIHNational Institute on Aging2023$2,077,693April 15, 2023March 31, 2026YUSHKEVICH, PAUL A.reporter.nih.gov
Sleep-dependent mechanisms of improving cerebral blood flow and reducing Alzheimer's disease progression by photobiomodulation with near-infrared lightNIHNational Institute on Aging2023 to 2025$2,074,140May 15, 2023January 31, 2028GERASHCHENKO, DMITRYreporter.nih.gov
Oligodendrocyte Progenitors and Mechanisms of Human Vascular White Matter InjuryNIHNational Institute of Neurological Disorders and Stroke2021 to 2023$2,066,705July 15, 2019April 30, 2026BACK, STEPHEN ARTHURreporter.nih.gov
tPA and Cerebrovascular Regulation in a Model of ß-amyloid PathologyNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$2,065,728April 1, 2018March 31, 2028PARK, LAIBAIKreporter.nih.gov
Predictors and Biomarkers for VCID versus Cognitive Recovery after Stroke Thrombectomy in Rural AppalachiaNIHNational Institute of Neurological Disorders and Stroke2023 to 2025$2,063,623April 15, 2023March 31, 2028HARP, JORDAN PATRICKreporter.nih.gov
THE SENDEP STUDY: LINKING MOLECULAR SENESCENCE CHANGES TO DEPRESSION AND COGNITIVE IMPAIRMENT IN LATE LIFENIHNational Institute of Mental Health2021 to 2023$2,057,113February 15, 2019December 31, 2024DINIZ, BRENO SATLERreporter.nih.gov
A New Molecular Target to Enhance Poststroke Cognitive RecoveryNIHNational Institute of Neurological Disorders and Stroke2023 to 2025$2,054,575May 1, 2023April 30, 2028LI, GUOHONGreporter.nih.gov
Stroke Minimization through Additive Anti-atherosclerotic Agents in Routine Treatment II StudyNIHNational Institute of Neurological Disorders and Stroke2022 to 2025$2,050,132September 1, 2022August 31, 2027OVBIAGELE, BRUCEreporter.nih.gov
A Drug Discovery Platform to Prioritize Development of Natural Product Neuromodulators for Treating Cognitive ImpairmentNIHNational Institute on Aging2024 to 2025$2,019,940December 1, 2023March 31, 2027BROWN, JEFFREY M.reporter.nih.gov
Astrocyte regulation of cerebral blood flow at the intersection of ischemia and Alzheimer's diseaseNIHNational Institute of Neurological Disorders and Stroke2023 to 2025$2,018,852September 22, 2023August 31, 2028MISHRA, ANUSHAreporter.nih.gov
Inflammation and delayed cognitive dysfunction after strokeNIHNational Institute of Neurological Disorders and Stroke2023$2,016,915March 15, 2023February 28, 2026DOYLE, KRISTIAN PAULreporter.nih.gov
iPSC-derived Neurovascular OrganoidsNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$2,012,834April 15, 2020March 31, 2026LIPPMANN, ETHANreporter.nih.gov
Astrocytes as governing pathological drivers of neurovascular dysfunction in ADNIHNational Institute on Aging2021 to 2025$2,005,277March 1, 2017February 29, 2028BACSKAI, BRIAN Jreporter.nih.gov
Microglial-Neurovascular Dynamics and Regulation of Neurovascular Structure and FunctionNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$1,994,764August 1, 2021May 31, 2026EYO, UKPONG BASSEYreporter.nih.gov
Non-contrast MR imaging of blood-brain-barrier permeability in Alzheimer's diseaseNIHNational Institute on Aging2021 to 2023$1,991,093May 1, 2020April 30, 2025LU, HANZHANGreporter.nih.gov
The blood-brain barrier and Alzheimer pathologyNIHNational Institute on Aging2023 to 2025$1,986,144September 30, 2023May 31, 2028JAGUST, WILLIAM J.reporter.nih.gov
Immunometabolic regulation after CNS injuryNIHNational Institute of Neurological Disorders and Stroke2023$1,975,262September 21, 2023August 31, 2026DHANDAPANI, KRISHNAN M.reporter.nih.gov
Modifying endothelial Piezo 1 function to improve brain perfusion in AD/ADRDNIHNational Institute on Aging2023 to 2025$1,974,645June 1, 2023February 29, 2028MARRELLI, SEAN Preporter.nih.gov
Lifespan and Cardiovascular Health Effects on The Brain in Humans and Great ApeNIHNational Institute on Aging2024 to 2025$1,966,730September 17, 2024May 31, 2029HOF, PATRICK Rreporter.nih.gov
Neurovascular circadian oscillation in health and Alzheimer's diseaseNIHNational Institute on Aging2023$1,966,145May 1, 2023April 30, 2026DANEMAN, RICHARDreporter.nih.gov
Chronic Alcohol, Dementia, and CNS Fluid HomeostasisNIHNational Institute on Alcohol Abuse and Alcoholism2022 to 2025$1,959,740September 20, 2022August 31, 2027MASON, GRAEME Freporter.nih.gov
Kerala-Einstein Aging StudyNIHNational Institute on Aging2021 to 2023$1,956,088August 1, 2011May 31, 2025VERGHESE, JOEreporter.nih.gov
Extracellular Mitochondria Transfer in Gray and White Matter for Ameliorating Sensorimotor and Cognitive Deficits After StrokeNIHNational Institute of Neurological Disorders and Stroke2022 to 2025$1,948,682February 15, 2022January 31, 2027HAYAKAWA, KAZUHIDEreporter.nih.gov
Imaging of brain oxygen extraction fraction in vascular contributions to dementiaNIHNational Institute of Neurological Disorders and Stroke2023 to 2025$1,944,714April 15, 2023March 31, 2028FAN, AUDREY PEIWENreporter.nih.gov
Deciphering the role of junctional adhesion molecule-A in neutrophil-driven inflammatory response in Alzheimer diseaseNIHNational Institute on Aging2023 to 2025$1,930,446August 15, 2023April 1, 2028ANDJELKOVIC-ZOCHOWSKA, ANUSKA V.reporter.nih.gov
APOE Allele Switching as a Therapeutic Approach for Alzheimer's DiseaseNIHNational Institute on Aging2023 to 2025$1,914,100December 1, 2022November 30, 2027JOHNSON, LANCE ALLENreporter.nih.gov
A Vascularized Micro-Organ platform for the study of Brain-BBB-Blood interactionNIHNational Heart, Lung, and Blood Institute2022 to 2024$1,904,995September 3, 2020August 31, 2025HUGHES, CHRISTOPHER C. W.reporter.nih.gov
Epidemiology of blood pressure responses to perturbations: Correlates and prognosis for vascular risk, end-organ damage, cognitive aging and preclinical Alzheimer's diseaseNIHNational Institute on Aging2023 to 2025$1,880,104June 1, 2022February 28, 2027RAMACHANDRAN, VASANreporter.nih.gov
Large artery stiffness and cerebrovascular dysfunction: Implications for cognitive impairment and neuropathologyNIHNational Institute on Aging2021 to 2024$1,864,502April 15, 2020February 28, 2026WALKER, ASHLEY ELIZABETHreporter.nih.gov
Modeling Alzheimer's Disease Related Dementias in the MarmosetNIHNational Institute of Neurological Disorders and Stroke2022 to 2023$1,851,822September 16, 2019August 31, 2025LEE, KUO-FENreporter.nih.gov
The Role of Pericytes in Brain Hypoperfusion in Alzheimer's Disease DevelopmentNIHNational Institute on Aging2023 to 2025$1,849,689April 15, 2023January 31, 2028FAN, HONGKUANreporter.nih.gov
Airborne metals, neurodegeneration, and dementia in the Adult Changes in Thought studyNIHNational Institute of Environmental Health Sciences2023 to 2025$1,847,274September 15, 2023June 30, 2028SUH, HELENreporter.nih.gov
Enlarged Perivascular Spaces as Markers of Vascular and Alzheimer pathology: predictors, pathophysiology and clinical consequencesNIHNational Institute on Aging2021 to 2023$1,846,394August 1, 2019April 30, 2026ROMERO, JOSE RAFAELreporter.nih.gov
Leveraging omics data to understand sleep health and its consequences among diverse Hispanics/LatinosNIHNational Heart, Lung, and Blood Institute2023 to 2025$1,844,341July 1, 2022June 30, 2027SOFER, TAMARreporter.nih.gov
Changes in Cerebrovascular Function with Aging in Normal and AD BrainNIHNational Institute on Aging2021 to 2024$1,840,772March 1, 2020December 31, 2025SONTHEIMER, HARALD Wreporter.nih.gov
ARCADIA CSI (Cognition and Silent Infarcts)NIHNational Institute of Neurological Disorders and Stroke2021 to 2023$1,817,706July 1, 2019September 30, 2024LANSBERG, MAARTEN Greporter.nih.gov
Capillary control of cerebral blood flow, and its disruption in small vessel diseaseNIHNational Heart, Lung, and Blood Institute2021 to 2025$1,817,568February 1, 2017February 28, 2027DABERTRAND, FABRICEreporter.nih.gov
Investigating Pathways from Adverse Pregnancy Outcomes to Alzheimer's Disease and Related Dementias: the nuMoM2b-Brain StudyNIHNational Institute on Aging2025$1,806,846July 15, 2024April 30, 2029MILLER, ELIZA Creporter.nih.gov
The role of microglia Nek6 in myocardial infarction-induced cognitive impairmentNIHNational Heart, Lung, and Blood Institute2021 to 2023$1,805,517July 1, 2020June 30, 2025DUTTA, PARTHAreporter.nih.gov
Understanding the Impact of Youth Onset Obesity and Type 2 Diabetes on the Neurovascular UnitNIHNational Institute of Neurological Disorders and Stroke2022 to 2025$1,797,545February 1, 2022January 31, 2027SHAH, AMY SANGHAVIreporter.nih.gov
The Effect of Sex Hormones on Cardiometabolic Outcomes in Men and Women with Diabetes: The Look AHEAD (Action for Health in Diabetes) StudyNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2024$1,796,808September 15, 2020June 30, 2025BENNETT, WENDY LYNETreporter.nih.gov
Proteomic Profiling of Patent Foramen Ovale Related Neurovascular InjuryNIHNational Institute of Neurological Disorders and Stroke2024$1,795,134July 1, 2010June 30, 2027NING, MINGMINGreporter.nih.gov
The role of IGF-1 signaling in vascular smooth muscle cells in age-related vascular cognitive impairment and dementiaNIHNational Institute on Aging2021 to 2025$1,778,358September 30, 2021May 31, 2027CONLEY, SHANNON Mreporter.nih.gov
Premenopausal bilateral oophorectomy and biomarkers of Alzheimer’s and cerebrovascular diseasesNIHNational Institute on Aging2025$1,775,401May 15, 2025April 30, 2030KANTARCI, KEJALreporter.nih.gov
Role of impaired cognitive states & risk factors in conversion to mixed dementiasNIHNational Institute on Aging2021 to 2023$1,771,960September 1, 2011January 31, 2025KRYSCIO, RICHARD J.reporter.nih.gov
Lasting Impacts: Dynamic, Fully Natural Bioprinted 3D Human Neurovascular Biomimetic Model to Study Traumatic Brain Injury PathophysiologyNIHNational Heart, Lung, and Blood Institute2023 to 2025$1,766,629September 15, 2021December 31, 2026MOYA, MONICA LIZETreporter.nih.gov
Cerebral Vascular Redox Regulation in StrokeNIHNational Institute of Neurological Disorders and Stroke2023 to 2025$1,746,383July 15, 2023April 30, 2028STRAUB, ADAM CARLreporter.nih.gov
Progressive Post-Stroke Cognitive Impairment: Mechanisms & InterventionNIHNational Institute of Neurological Disorders and Stroke2024$1,745,096September 15, 2018August 31, 2027ERGUL, ADVIYEreporter.nih.gov
Understanding the role of the cerebral microvasculature in brain agingNIHNational Institute on Aging2023 to 2025$1,718,194August 1, 2023April 30, 2028RUTKAI-GREEN, IBOLYAreporter.nih.gov
Genetic Architecture of Aging-Related TDP-43 and Mixed Pathology DementiaNIHNational Institute on Aging2023$1,714,473April 15, 2023March 31, 2026FARDO, DAVID WILLIAMreporter.nih.gov
Mechanisms underlying Sex differences in Cerebral Amyloid Angiopathy: The Fibrin-Microglia CrosstalkNIHNational Institute on Aging2023 to 2025$1,713,060April 1, 2023March 31, 2029MANWANI, BHARTIreporter.nih.gov
Clarifying the association of depressive symptoms with cortico-limbic tau, cerebral blood flow, neurodegeneration, and longitudinal cognitive decline in individuals with mild cognitive impairmentNIHNational Institute on Aging2025$1,711,908April 15, 2025March 31, 2030MACKIN, ROBERT SCOTTreporter.nih.gov
Systemic and dietary advanced glycation end products in type 2 diabetes-related cognitive decline and incident dementia: effects on Alzheimer's pathology and cerebrovascular diseaseNIHNational Institute on Aging2021 to 2023$1,702,136February 1, 2019November 30, 2023SCHNAIDER BEERI, MICHALreporter.nih.gov
Alzheimer's Disease-Related Dementia Models by Precision Editing and Relevant Genetic x Environmental ExposuresNIHNational Institute of Neurological Disorders and Stroke2023 to 2024$1,699,708September 16, 2019August 31, 2025O'CONNELL, KRISTEN Mreporter.nih.gov
Gut Immunity, Neurovascular Dysregulation and Cognitive ImpairmentNIHNational Institute of Neurological Disorders and Stroke2022 to 2025$1,695,000September 18, 2022August 31, 2027FARACO, GIUSEPPEreporter.nih.gov
Neuronal and vascular interactions in the CNSNIHNational Heart, Lung, and Blood Institute2021 to 2023$1,693,594July 15, 2020June 30, 2024GU, CHENGHUAreporter.nih.gov
Nicotinamide riboside supplementation for treating arterial stiffness and elevated systolic blood pressure in patients with moderate to severe CKDNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2023$1,693,290May 23, 2019March 31, 2025CHONCHOL, MICHEL BENJAMINreporter.nih.gov
Neuroinflammatory Mechanisms of Vascular Cognitive ImpairmentNIHNational Institute on Aging2023$1,659,018September 15, 2017August 31, 2026ALKAYED, NABIL Jreporter.nih.gov
Mechanisms of cognitive impairment caused by atherosclerosis and red blood cell released ATPNIHNational Institute of Neurological Disorders and Stroke2024 to 2025$1,653,797August 1, 2024July 31, 2029HE, PINGNIANreporter.nih.gov
Race/ethnicity and Environmental Stressors: POtential drivers of Dementia and stroke inequities RESPOnDNIHNational Institute of Neurological Disorders and Stroke2024 to 2025$1,644,642July 15, 2024June 30, 2029PESCADOR JIMENEZ, MARCIA IXCHELreporter.nih.gov
Microvascular Stress as a Pathway to Neurodegeneration in Alzheimer'sNIHNational Institute on Aging2022 to 2025$1,641,575February 1, 2022January 31, 2027BENNETT, RACHEL ELISEreporter.nih.gov
Age-related Hypertension and Vascular Cognitive ImpairmentNIHNational Institute on Aging2022 to 2023$1,638,234February 1, 2022May 31, 2023WAINFORD, RICHARD DAVIDreporter.nih.gov
Post-stroke Cognitive Impairment and DementiaNIHNational Institute on Aging2024 to 2025$1,629,398September 15, 2024July 31, 2029XIAN, YINGreporter.nih.gov
Digital Cognitive Assessment of Preclinical Alzheimer's Disease and Related DementiasNIHNational Institute on Aging2024 to 2025$1,628,248August 1, 2024April 30, 2029AU, RHODAreporter.nih.gov
Modeling Cerebral Microbleeds and Striatal Brain Iron in Adult Congenital Heart Disease in Relationship to Differential Genetic Risk for Alzheimer DiseaseNIHNational Heart, Lung, and Blood Institute2021 to 2023$1,626,747June 1, 2020May 31, 2025CESCHIN, RAFAEL Creporter.nih.gov
Late Pathologies of Exposure to Repetitive Head Impacts from Contact Sports: White Matter and Vascular Contributions to Cognitive Impairment, Dementia, and Neuropsychiatric SymptomsNIHNational Institute of Neurological Disorders and Stroke2024 to 2025$1,626,188September 15, 2021August 31, 2027ALOSCO, MICHAELreporter.nih.gov
Locus Coeruleus Imaging Markers in Preclinical Alzheimers disease, Cerebrovascular Disease and Cognitive DeclineNIHNational Institute on Aging2023$1,623,978April 1, 2023July 31, 2023NATION, DANIEL Areporter.nih.gov
Understanding and Mitigating Vascular Side-Effects Associated with Anti-Amyloid ImmunotherapyNIHNational Institute of Neurological Disorders and Stroke2024 to 2025$1,615,518June 1, 2024May 31, 2029LEMERE, CYNTHIA Areporter.nih.gov
Gut microbiome-related metabolites and cognitive impairmentNIHNational Institute on Aging2024 to 2025$1,606,250September 15, 2024July 31, 2029KIMBERLY, WILLIAM TAYLORreporter.nih.gov
A Squirrel Monkey Model of Alzheimer’s Disease: Developing Behavioral, Blood, and CSF BiomarkersNIHNational Institute on Aging2024 to 2025$1,605,066September 15, 2021May 31, 2027HOPKINS, WILLIAM Dreporter.nih.gov
Pathophysiological mechanisms of hypoperfusion in mouse models of Alzheimer?s disease and small vessel diseaseNIHNational Institute on Aging2023 to 2025$1,597,303May 15, 2023January 31, 2028WEI, ZHILIANGreporter.nih.gov
Elucidating the Link Between Oral Health and Dementia Subtypes: A Multifaceted Study on the Biological Pathways and Social DeterminantsNIHNational Institute on Aging2024 to 2025$1,594,142August 15, 2024April 30, 2029QI, XIANGreporter.nih.gov
Establishing a Brain Health IndexNIHNational Institute of Neurological Disorders and Stroke2024 to 2025$1,593,534January 7, 2023April 30, 2027THOMAS, ROBERT JOSEPHreporter.nih.gov
Preclinical evaluation of tacrolimus in a canine model of Alzheimer's diseaseNIHNational Institute on Aging2021 to 2025$1,593,298September 15, 2017May 31, 2027HEAD, ELIZABETHreporter.nih.gov
An Integrative Computational Multimodal approach to disentangle Pathophysiologic Heterogeneity of age-related White Matter HyperintensitiesNIHNational Institute on Aging2024 to 2025$1,585,301September 1, 2024May 31, 2029PHUAH, CHIA-LINGreporter.nih.gov
Regulation of Flt 1 Splicing by Fibronectin and Integrin Signaling During AgingNIHNational Institute of Neurological Disorders and Stroke2023$1,583,383September 19, 2023August 31, 2026MURPHY, PATRICK ANDRIESreporter.nih.gov
Stem Cell-Derived Exosomes, MrgD and Vascular Cognitive Impairment in AgingNIHNational Institute on Aging2021 to 2025$1,582,923September 15, 2017April 30, 2028JARAJAPU, YAGNAreporter.nih.gov
Na/H Exchanger in Microglial Metabolism and FunctionNIHNational Institute of Neurological Disorders and Stroke2022 to 2025$1,578,265February 4, 2005June 30, 2027SUN, DANDANreporter.nih.gov
Meningeal Stem Cell Signals for Improving Sensorimotor and Cognitive Outcomes After StrokeNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$1,564,073February 1, 2020November 30, 2025HAYAKAWA, KAZUHIDEreporter.nih.gov
Integrated Cerebral Blood Flow RegulationNIHNational Institute of Neurological Disorders and Stroke2022 to 2025$1,562,976December 1, 2021November 30, 2026TRAN, CAM HA THAIreporter.nih.gov
Cofilin Signaling in Hemorrhagic StrokeNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$1,560,785June 15, 2020March 31, 2026SHAH, ZAHOOR AHMADreporter.nih.gov
MenoBrain: A Longitudinal Investigation of Menopause and Brain HealthNIHNational Institute on Aging2025$1,558,726January 1, 2025December 31, 2029THURSTON, REBECCA Creporter.nih.gov
Peripheral immunity and the aging brain: Studying the relationship of platelet and neutrophil activity with markers of vascular contributions to cognitive decline and dementiaNIHNational Institute on Aging2025$1,552,000September 15, 2025May 31, 2030RAMOS-CEJUDO, JAIMEreporter.nih.gov
Vascular Imaging Biomarker Relationships to Alzheimer’s disease (VIBRA)NIHNational Institute on Aging2024 to 2025$1,551,084September 15, 2024May 31, 2029HABES, MOHAMADreporter.nih.gov
Altered Microglia States and Microglia-Endothelial Cell Axis in Relation to White Matter Disease Progression in VCIDNIHNational Institute of Neurological Disorders and Stroke2023 to 2025$1,549,664September 18, 2023August 31, 2028HORSBURGH, KARENreporter.nih.gov
Physiological imaging markers in vascular contributions to cognitive impairment and dementia (VCID)NIHNational Institute on Aging2024 to 2025$1,541,901December 5, 2023November 30, 2028LU, HANZHANGreporter.nih.gov
Stalled capillary flow: a novel mechanism for hypoperfusion in Alzheimer diseaseNIHNational Institute on Aging2024 to 2025$1,537,776May 15, 2015April 30, 2026SCHAFFER, CHRIS Breporter.nih.gov
Adiponectin on cerebrovascular regulation in vascular cognitive impairment and dementia (VCID)NIHNational Institute of Neurological Disorders and Stroke2022 to 2025$1,535,200January 1, 2022December 31, 2026HU, XIAOMINGreporter.nih.gov
Effects of the renin angiotensin system on MRI volumetric measures and cognitive function in the Alzheimer's disease process: the LookAHEAD studyNIHNational Institute on Aging2022 to 2024$1,534,661July 1, 2022March 31, 2026YASAR, SEVILreporter.nih.gov
Longitudinal impact of midlife cerebrovascular pulsatility on brain tissue integrity and cognitive agingNIHNational Institute on Aging2024 to 2025$1,532,721September 15, 2024May 31, 2029MARTENS, CHRISTOPHERreporter.nih.gov
Multimodal in Vivo and Postmortem Analysis of ARIA-Relevant PathophysiologyNIHNational Institute of Neurological Disorders and Stroke2025$1,531,729August 1, 2025July 31, 2030KOFLER, JULIA Kreporter.nih.gov
Humanization of a Notch 3 Agonist Antibody for Pre-Clinical Development of a CADASIL TreatmentNIHNational Institute of Neurological Disorders and Stroke2024 to 2025$1,529,075January 15, 2021December 31, 2025ARBOLEDA-VELASQUEZ, JOSEPHreporter.nih.gov
Remote ischemic Conditioning Promotes Cerebrovascular Recovery after Intracerebral HemorrhageNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$1,523,768September 1, 2020July 31, 2025DHANDAPANI, KRISHNAN M.reporter.nih.gov
Air pollution and noise exposures in relation to dementia: from brain imaging markers to clinical diseaseNIHNational Institute on Aging2021 to 2023$1,521,542February 1, 2020July 31, 2025WEUVE, JENNIFERreporter.nih.gov
A New Informatics Approach for Detection of Cerebrovascular AbnormalitiesNIHNational Library of Medicine2022 to 2025$1,521,500August 15, 2022May 31, 2027YOUNG, GEOFFREYreporter.nih.gov
Cerebrovascular reactivity as a VCID biomarker in CADASILNIHNational Institute on Aging2024 to 2025$1,521,356September 30, 2024June 30, 2029BARNES, JILL NICOLEreporter.nih.gov
Lymphatic drainage dysfunction in chronic hypertensionNIHNational Heart, Lung, and Blood Institute2024 to 2025$1,520,151July 15, 2024May 31, 2028BENVENISTE, HELENE Dreporter.nih.gov
Amyloid-β Disruption of Pericyte Control of Capillary HemodynamicsNIHNational Institute on Aging2023 to 2025$1,519,812April 1, 2023March 31, 2028GONZALES, ALBERT LOUISreporter.nih.gov
Protein Arginine Methyltransferases in Alzheimer's diseaseNIHNational Institute on Aging2024 to 2025$1,518,787May 1, 2024April 30, 2029LIN, HUNG WEN (KEVIN)reporter.nih.gov
Elucidating the role of placental growth factor in diffuse white matter diseaseNIHNational Institute of Neurological Disorders and Stroke2021 to 2023$1,517,370April 1, 2020July 15, 2023WILCOCK, DONNA Mreporter.nih.gov
Ion Channel Dysfunction in Small Vessel Disease of the BrainNIHNational Institute of Neurological Disorders and Stroke2021 to 2023$1,516,504April 15, 2019March 31, 2026NELSON, MARK Treporter.nih.gov
Role of Monocyte Delta Like-4 (Dll4) in HIV-Associated Cerebral Small Vessel DiseaseNIHNational Institute of Neurological Disorders and Stroke2024 to 2025$1,514,509August 1, 2024June 30, 2029SCHIFITTO, GIOVANNIreporter.nih.gov
Intrinsic CSF outflow metrics for mild cognitive impairment and Alzheimer's diseaseNIHNational Institute on Aging2024 to 2025$1,513,078May 15, 2024January 31, 2029MIYAZAKI, MITSUEreporter.nih.gov
The impact of blood pressure variability on neurovascular functionNIHNational Institute of Neurological Disorders and Stroke2023 to 2025$1,512,730August 15, 2023May 31, 2028FILOSA, JESSICA Areporter.nih.gov
Covert Cerebrovascular Disease Detected by Artificial Intelligence (C2D2AI): Pragmatic Neuroimaging Biomarkers for Future Stroke and Dementia RiskNIHNational Institute of Neurological Disorders and Stroke2024 to 2025$1,504,012February 15, 2024January 31, 2028KENT, DAVID Mreporter.nih.gov
Using a Natural Experiment to Evaluate the Long-Term Effects of Neighborhood Deprivation on Alzheimer's Disease and Vascular Risk FactorsNIHNational Institute on Aging2021 to 2023$1,498,177May 1, 2019February 29, 2024HAMAD, RITAreporter.nih.gov
Multi-Ethnic Study of Atherosclerosis- Cellular Exosomes in Neurodegeneration and Dementia (MESA-CEND)NIHNational Institute on Aging2024 to 2025$1,486,033August 15, 2021July 31, 2026DEEP, GAGANreporter.nih.gov
Structural analysis of tau associated with parenchymal and vascular prion protein amyloidosisNIHNational Institute on Aging2024 to 2025$1,476,148April 1, 2021March 31, 2026VIDAL, RUBENreporter.nih.gov
Chemogenetic Neurovascular Oxidative Stress: Neurodegeneration and Cardiac RemodelingNIHNational Institute of Neurological Disorders and Stroke2024 to 2025$1,475,301February 2, 2024January 31, 2029MICHEL, THOMASreporter.nih.gov
A TIMEM252-dependent Microvascular Endophenotype in Alzheimer’s DiseaseNIHNational Institute of Neurological Disorders and Stroke2024 to 2025$1,466,564April 1, 2021March 31, 2026ZHAO, ZHENreporter.nih.gov
Age-related vascular cognitive impairment: role of endothelial senescenceNIHNational Institute on Aging2021 to 2024$1,450,000August 1, 2020July 31, 2025CSISZAR, ANNAreporter.nih.gov
Central noradrenergic mechanisms of cerebrovascular pathology in Alzheimer's diseaseNIHNational Institute on Aging2021 to 2023$1,445,578April 1, 2019January 31, 2025COUNTS, SCOTT Ereporter.nih.gov
Non-Invasive MRI Markers to Elicit the Role of Vascular Disease in CADASIL Compared to Normal AgingNIHNational Institute on Aging2024 to 2025$1,438,740February 15, 2024January 31, 2029EISENMENGER, LAURA BURNSreporter.nih.gov
Exploring the origins of myelin abnormalities in normal ageing and in vascular dementiaNIHNational Institute on Aging2024 to 2025$1,434,950May 1, 2021April 30, 2026POPKO, BRIAN Jreporter.nih.gov
Cerebral Small Vessels in Motor and Cognitive Decline: Neuroimaging Signatures of Vulnerability & ResilienceNIHNational Institute of Neurological Disorders and Stroke2024 to 2025$1,434,665June 1, 2014March 31, 2027SOROND, FARZANEH Areporter.nih.gov
Oligodendrocyte Precursor Cells Regulate White Matter Remodeling in Vascular Cognitive Impairment and DementiaNIHNational Institute of Neurological Disorders and Stroke2021 to 2023$1,434,255July 1, 2019June 30, 2026ARAI, KENreporter.nih.gov
The protective role of microglia in preventing hypoxic disruption of blood-brain barrier integrity and VCIDNIHNational Institute of Neurological Disorders and Stroke2024 to 2025$1,423,377February 15, 2021January 31, 2027MILNER, D. RICHARDreporter.nih.gov
7T Vascular and Molecular Imaging of SVD: Sex, Equol, and Risk of Alzheimer’s DiseaseNIHNational Institute on Aging2024 to 2025$1,419,249September 1, 2024May 31, 2029WU, MINJIEreporter.nih.gov
Hypoperfusion, Hemodynamic Control Domains and Neurovascular Dysregulation in AD brain pathologyNIHNational Institute on Aging2023 to 2025$1,414,971May 15, 2023January 31, 2027TURNER, DENNIS ALANreporter.nih.gov
Investigating the combined role of APOE4 and ketogenic diets in Alzheimer's diseaseNIHNational Institute on Aging2024 to 2025$1,410,026August 15, 2024April 30, 2029BLANCHARD, JOEL WILLIAMreporter.nih.gov
Social Reward Processing Across the Lifespan: Identifying Risk Factors for Financial ExploitationNIHNational Institute on Aging2024 to 2025$1,406,995April 15, 2021March 31, 2027SMITH, DAVID VICTORreporter.nih.gov
Pathways between OSA and cognitive decline in older women and men: a longitudinal population-based studyNIHNational Institute on Aging2021 to 2024$1,404,000August 15, 2021April 30, 2026BRALEY, TIFFANY JOYreporter.nih.gov
The Role of Pericytes in the Vascular Dysfunction of SepsisNIHNational Institute of General Medical Sciences2023 to 2025$1,381,815May 1, 2023March 31, 2028FAN, HONGKUANreporter.nih.gov
Non-invasive MRI mapping of BBB water exchange rate and permeabilityNIHNational Institute of Neurological Disorders and Stroke2024 to 2025$1,380,588August 1, 2024May 31, 2029WANG, DANNY JJreporter.nih.gov
Cerebrovascular involvement in Alzheimer's Disease: PAR4 AntagonismNIHNational Institute on Aging2024 to 2025$1,376,756May 15, 2021April 30, 2026HAMM, HEIDI Ereporter.nih.gov
Cortical Complications of Perimenopause and Obstructive Sleep Apnea in Underrepresented Middle-Aged Women with Type 2 DiabetesNIHNational Institute on Aging2023 to 2024$1,358,585September 20, 2023August 31, 2025GORNIAK, STACEY LYNNreporter.nih.gov
White Matter Injury and Repair in Vascular Cognitive Impairment and DementiaNIHNational Institute of Neurological Disorders and Stroke2023$1,357,361April 1, 2023March 31, 2026HU, XIAOMINGreporter.nih.gov
A QUANTITATIVE, PREDICTIVE MODEL OF VASCULAR REMODELING IN HEALTH AND DISEASENIHNational Heart, Lung, and Blood Institute2024 to 2025$1,356,041July 10, 2024May 31, 2028SCHWARTZ, MARTIN Areporter.nih.gov
Astrocytic WNK-SPAK-NKCC1 Cascade in White Matter Astrogliosis and InjuryNIHNational Institute of Neurological Disorders and Stroke2022 to 2024$1,349,563April 15, 2022September 1, 2024BHUIYAN, MOHAMMAD IQBAL HOSSAINreporter.nih.gov
Examining a dose-dependent exercise intervention on cerebrovascular plasticity in late adulthoodNIHNational Institute on Aging2023 to 2025$1,348,549September 1, 2023May 31, 2027KIM, TAEreporter.nih.gov
Chemogenetic Mouse Models for Cerebral Hypoperfusion and VCIDNIHNational Institute of Neurological Disorders and Stroke2024 to 2025$1,334,981July 1, 2024June 30, 2026SHIH, ANDY Yreporter.nih.gov
Endothelial progenitor cells and neurovascular injury in the aging brainNIHNational Institute on Aging2021 to 2023$1,321,673September 1, 2019August 1, 2023NATION, DANIEL Areporter.nih.gov
Targeting Kruppel-like Transcription Factor for White and Grey Matter Protection in Vascular Cognitive Impairment and DementiaNIHNational Institute of Neurological Disorders and Stroke2023 to 2025$1,316,276July 1, 2023April 30, 2029YIN, KEJIEreporter.nih.gov
O-glycosylation of cysteine-rich modulesNIHNational Institute of General Medical Sciences2023 to 2025$1,313,700January 1, 2023November 30, 2027HALTIWANGER, ROBERT S.reporter.nih.gov
CRCNS: Waste-clearance flows in the brain measured using physics-informed neural networkNIHNational Center for Complementary & Integrative Health2022 to 2025$1,284,101September 19, 2022June 30, 2027KELLEY, DOUGLAS Hreporter.nih.gov
Endothelial progenitor cells and neurovascular injury in the agingNIHNational Institute on Aging2023 to 2025$1,282,491September 1, 2019June 30, 2030NATION, DANIEL Areporter.nih.gov
Large-Scale Genomic Analysis of Aging-Related Cognitive Change Prior to Dementia OnsetNIHNational Institute on Aging2024 to 2025$1,278,361August 15, 2021July 31, 2027TUCKER-DROB, ELLIOT MAXreporter.nih.gov
Long non-coding RNAs mediate white and grey matter integrity in vascular cognitive impairment and dementiaNIHNational Institute of Neurological Disorders and Stroke2024 to 2025$1,267,624April 16, 2024March 31, 2029YIN, KEJIEreporter.nih.gov
Pathogenic exosomes during herpes zoster mediate increased vascular dementia riskNIHNational Institute on Aging2024 to 2025$1,264,545September 20, 2024July 31, 2029BUBAK, ANDREW Nreporter.nih.gov
Mapping the perivascular reticular network in health, aging, and ADNIHNational Institute on Aging2023$1,246,362September 1, 2023August 31, 2026MEHTA, RUPAL I.reporter.nih.gov
Single domain antibody development for improving vascular dysfunction in Alzheimer’s diseaseNIHNational Institute on Aging2025$1,244,775September 20, 2025May 31, 2027HUSSAIN, SAZIDreporter.nih.gov
A Cerebrovascular Basis for Sex Differences in Alzheimer's Disease RiskNIHNational Institute on Aging2021 to 2023$1,237,040April 15, 2020March 31, 2026WU, MINJIEreporter.nih.gov
Neutrophil-driven vascular inflammation in VCID and Mixed Alzheimer's DiseaseNIHNational Institute of Neurological Disorders and Stroke2024 to 2025$1,235,417September 17, 2024August 31, 2029BRACKO, OLIVERreporter.nih.gov
The roles of pericyte-derived laminin in neurovascular function and neurodegenerationNIHNational Institute on Aging2024 to 2025$1,221,061September 30, 2021August 31, 2026YAO, YAOreporter.nih.gov
Using Photobiomodulation to Alleviate Brain Hypoperfusion in Alzheimer's DiseaseNIHNational Institute on Aging2024 to 2025$1,190,898May 15, 2023January 31, 2028LIN, HUNG WEN (KEVIN)reporter.nih.gov
Molecular Markers of Cerebrovascular Pathologies in Alzheimer's Disease and Related DementiasNIHNational Institute of Neurological Disorders and Stroke2024 to 2025$1,188,426September 1, 2024August 31, 2028OBENAUS, ANDREreporter.nih.gov
Heparan sulfate proteoglycan in the brain vascular clearance of amyloid-β and Alzheimer's diseaseNIHNational Institute on Aging2024 to 2025$1,187,855August 15, 2021July 31, 2027WANG, LIANCHUNreporter.nih.gov
Cardiovascular and Cerebrovascular Risk Factors for Mobility Limitation in the Jackson Heart StudyNIHNational Institute on Aging2021 to 2023$1,169,210May 1, 2020February 28, 2026ODDEN, MICHELLE CHRISTINAreporter.nih.gov
Imaging cerebral waste clearance responses during exosome treatment of diabetesNIHNational Institute of Diabetes and Digestive and Kidney Diseases2024 to 2025$1,164,662April 15, 2024March 31, 2029JIANG, QUANreporter.nih.gov
Adducin, actin cytoskeleton and cognitive impairmentsNIHNational Institute on Aging2021 to 2023$1,162,500April 1, 2019January 31, 2025WILLIAMS, JAN MICHAELreporter.nih.gov
Cerebral microhemorrhages and gait abnormalities in agingNIHNational Institute on Aging2021 to 2025$1,154,620September 15, 2024June 30, 2030CSISZAR, ANNAreporter.nih.gov
Neurocognitive Impairment Assessment in Symptomatic Carotid Occlusion Recanalized Endovascularly: NIA SCORENIHNational Institute on Aging2022 to 2023$1,147,757April 15, 2020March 31, 2024HASAN, DAVID M.reporter.nih.gov
StAtins Use in intRacereberal hemorrhage patieNts MRI (SATURN MRI) Ancillary StudyNIHNational Institute of Neurological Disorders and Stroke2025$1,144,357August 15, 2021August 31, 2027SELIM, MAGDY Hreporter.nih.gov
Effect of diabetes and AD pathology on brain imaging and cognition in Latino adultsNIHNational Institute on Aging2025$1,134,850September 30, 2022August 31, 2027YASSINE, HUSSEIN Nreporter.nih.gov
Mechanistic inquiry of GPR68-mediated neuroprotection against post-stroke deficits and VCIDNIHNational Institute of Neurological Disorders and Stroke2023 to 2025$1,131,657September 25, 2023August 31, 2029ZHA, XIANGMINGreporter.nih.gov
Interactions between the chronic sequelae of stroke and Alzheimer's diseaseNIHNational Institute on Aging2021 to 2023$1,130,696September 1, 2019May 31, 2025DOYLE, KRISTIAN PAULreporter.nih.gov
Vasculotide promotes cognitive improvement in rats with vascular dementiaNIHNational Institute on Aging2021 to 2023$1,128,750August 1, 2019April 30, 2025CHOPP, MICHAELreporter.nih.gov
Clinical Spectrum and Societal Impact of Cognitive Impairment with HIV in UgandaNIHNational Institute on Aging2024$1,103,953September 15, 2024August 31, 2025SIEDNER, MARK Jreporter.nih.gov
Blood Pressure and ADRD in African Americans: the Jackson Heart StudyNIHNational Institute on Aging2023$1,102,700September 15, 2019May 31, 2026PALTA, PRIYAreporter.nih.gov
The Contribution of Late Onset Unexplained Epilepsy to Cognitive Decline and its Interaction with Vascular and Alzheimer's Disease PathologiesNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$1,098,488September 1, 2021June 30, 2027SARKIS, RANIreporter.nih.gov
Epigenetic Aging Biomarkers of Mild Cognitive Impairment, Alzheimer's Disease and Related Dementias, and Brain AgingNIHNational Institute on Aging2024 to 2025$1,084,069August 1, 2021July 31, 2027SHADYAB, ALADDINreporter.nih.gov
Elucidating the role of placental growth factor in diffuse white matter diseaseNIHNational Institute of Neurological Disorders and Stroke2023 to 2024$1,084,034June 1, 2023March 31, 2026WILCOCK, DONNA Mreporter.nih.gov
Novel regulation of vascular dementiaNIHNational Institute on Aging2024 to 2025$1,067,631August 1, 2023April 30, 2027CHEN, YABINGreporter.nih.gov
Contributions of educational quality and occupational complexity on racial and ethnic inequities in brain health and Alzheimer's disease and related dementiaNIHNational Institute on Aging2021 to 2023$1,059,807September 15, 2019May 31, 2025GILSANZ, PAOLAreporter.nih.gov
Targeting RBC dysfunction in VCIDNIHNational Institute of Neurological Disorders and Stroke2024 to 2025$1,043,628July 15, 2021June 30, 2027HESS, DAVID C.reporter.nih.gov
Elucidating microvascular contributions to cognitive impairment at single-cell resolutionNIHNational Institute of Neurological Disorders and Stroke2022 to 2023$1,042,742July 1, 2022December 31, 2023YANG, ANDREW CHRISreporter.nih.gov
Enhanced APOE2 Expression into Brain for Therapeutic Strategy for Alzheimer's DiseaseNIHNational Institute on Aging2024 to 2025$1,040,909May 15, 2021April 30, 2027SINGH, JAGDISHreporter.nih.gov
Single-cell multi-region transcriptional and epigenomic dissection of VCID.NIHNational Institute of Neurological Disorders and Stroke2025$1,034,087September 15, 2022August 31, 2027KELLIS, MANOLISreporter.nih.gov
Blood-brain-barrier and white matter mechanisms underlying dementiaNIHNational Institute of Neurological Disorders and Stroke2024 to 2025$1,032,543February 1, 2021January 31, 2027LIAO, FRANCESCA-FANGreporter.nih.gov
The role of PFAS in lipid-mediated vascular contributions to cognitive impairment and dementia: PFAS VascCog Longitudinal StudyNIHNational Institute on Aging2024 to 2025$1,032,220May 15, 2024January 31, 2029GARDENER, HANNAHreporter.nih.gov
The Role of the Hippocampal Vasculature in Vascular Cognitive Impairment and DementiaNIHNational Institute of Neurological Disorders and Stroke2024 to 2025$1,029,468April 1, 2022March 31, 2027CHAPMAN, ABBIE Creporter.nih.gov
Accelerated Age-related Cognitive Decline: Impact of Exercise on Executive Function and Neuroplasticity (EXEC-study)NIHNational Institute on Aging2022 to 2023$1,028,240May 1, 2022June 30, 2023BRONAS, ULF Greporter.nih.gov
Targeting Receptor Interacting Protein Kinase-1 in the Chronic Period of Intracerebral HemorrhageNIHNational Institute of Neurological Disorders and Stroke2024 to 2025$1,018,126January 1, 2024December 31, 2028WHALEN, MICHAEL Jreporter.nih.gov
Validation of Novel Plasma Biomarkers for Mixed Etiology DementiaNIHNational Institute on Aging2021 to 2025$1,005,750September 10, 2021May 31, 2026VANDEVREDE, LAWRENreporter.nih.gov
Characterizing white matter injury in Alzheimer's diseaseNIHNational Institute on Aging2025$1,001,700September 15, 2025August 31, 2029ROYSE, SARAH KOLIBASHreporter.nih.gov
The effects of HIV-associated extracellular vesicles on mitochondrial dysfunction in brain microvesselsNIHNational Institute of Neurological Disorders and Stroke2024 to 2025$984,666July 10, 2024June 30, 2029CHANDRA, PARTHAreporter.nih.gov
BBB Permeability Imaging in CADASILNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$982,575February 1, 2020January 31, 2026WANG, DANNY JJreporter.nih.gov
Cerebrovascular resistance in cognitive aging and Alzheimer's disease riskNIHNational Institute on Aging2021 to 2023$979,298August 1, 2019August 1, 2023NATION, DANIEL Areporter.nih.gov
The Role of the Hippocampal Vasculature in Vascular Cognitive Impairment and DementiaNIHNational Institute of Neurological Disorders and Stroke2022 to 2023$959,269April 1, 2022December 31, 2023CHAPMAN, ABBIE Creporter.nih.gov
The mediating role of Slow Wave Sleep and Vascular Risk Factors on Alzheimer Disease related disparity between African-Americans and non-Hispanic WhitesNIHNational Institute on Aging2021 to 2025$957,738May 15, 2021April 30, 2026BUBU, OMONIGHO A MICHAELreporter.nih.gov
Stroke Disordered Breathing and its Impact on Cognitive Decline in Aging, Alzheimer's Disease and Cerebral Amyloid AngiopathyNIHNational Institute on Aging2024$953,252September 11, 2020August 31, 2025LI, JUNreporter.nih.gov
Cognitive Aging Brain Morphology and Arrhythmias in Hispanics/Latinos: Implications for Prevention and Management of Alzheimer's Disease-Related DementiasNIHNational Institute of Neurological Disorders and Stroke2025$947,878April 1, 2022March 31, 2027CHEN, LIN YEEreporter.nih.gov
Silent Brain Infarcts in Spontaneous Intracerebral Hemorrhage as a Prognostic Biomarker for Vascular contributions to Cognitive Impairment and Dementia (VCID)NIHNational Institute of Neurological Disorders and Stroke2024 to 2025$942,355September 17, 2024August 31, 2029GARG, RAJEEV KUMARreporter.nih.gov
Simultaneous PET/MR Imaging of Brain Glucose and Oxygen Metabolism to Assess Energy Deficits Related to Alzheimer's Disease and the Response to InterventionNIHNational Institute of Neurological Disorders and Stroke2024 to 2025$924,806March 26, 2024February 29, 2028WEHRLI, FELIX Wreporter.nih.gov
TRP channels as fundamental sensors of the cerebral microcirculationNIHNational Heart, Lung, and Blood Institute2025$924,000February 1, 2021December 31, 2027EARLEY, SCOTTreporter.nih.gov
Establishing Mechanisms Between Traumatic Brain Injury and Dementia Using Epidemiology, Clinical Studies, Blood-Based Biomarkers, and Neuroimaging BiomarkersNIHNational Institute of Neurological Disorders and Stroke2022 to 2025$883,830May 1, 2022April 30, 2027SCHNEIDER, ANDREA LAUREN CHRISTMANreporter.nih.gov
Cerebromicrovascular rejuvenation by heterochronic blood exchangeNIHNational Institute on Aging2024 to 2025$875,461June 1, 2021May 31, 2027UNGVARI, ZOLTAN ISTVANreporter.nih.gov
Cognitive decline and dementia in older Kerala AmericansNIHNational Institute on Aging2024$855,415May 1, 2024February 28, 2029VERGHESE, JOEreporter.nih.gov
Endothelial complement C3a receptor mediated cerebral injury in a murine stroke model.NIHNational Institute of Neurological Disorders and Stroke2024$853,135September 1, 2024August 31, 2029DUCRUET, ANDREW FREDERICKreporter.nih.gov
The Impact of High Fat Diet on Brainstem Vagal RegulationNIHNational Heart, Lung, and Blood Institute2022 to 2023$837,791April 1, 2022March 31, 2027BOYCHUK, CARIE RENEEreporter.nih.gov
Therapeutic effects of APOE regulation via LNP-RNA formulations in Alzheimer's diseaseNIHNational Institute on Aging2025$835,417June 1, 2025March 31, 2030DONG, YIZHOUreporter.nih.gov
Characterizing microvascular impairment in adults with elevated genetic risk for Alzheimer's DiseaseNIHNational Institute on Aging2025$831,583March 15, 2025January 31, 2030JUTTUKONDA, MEHER Rreporter.nih.gov
PET imaging for in-vivo quantification of demyelination and cerebral perfusion in Alzheimer's DiseaseNIHNational Institute on Aging2024 to 2025$829,125September 30, 2024May 31, 2029GUEHL, NICOLAS JEANreporter.nih.gov
Aerobic Exercise for Optimizing Cognitive and Brain Health In Remitted Late-Life DepressionNIHNational Institute of Mental Health2021 to 2025$828,059December 14, 2020November 30, 2026GUJRAL, SWATHIreporter.nih.gov
Cognitive decline and dementia in older Kerala AmericansNIHNational Institute on Aging2025$820,874May 1, 2024February 28, 2029VERGHESE, JOEreporter.nih.gov
Cognitive heterogeneity in those with high Alzheimer's Disease RiskNIHNational Institute on Aging2025$817,404September 30, 2018November 30, 2028AU, RHODAreporter.nih.gov
GPR4 in blood brain barrier dysfunction in brain ischemiaNIHNational Institute of Neurological Disorders and Stroke2022 to 2023$815,761July 1, 2022August 1, 2024ZHA, XIANGMINGreporter.nih.gov
Identifying compounds that target APOE4 associated brain endothelial dysfunctionNIHNational Institute of Neurological Disorders and Stroke2023 to 2024$809,521February 3, 2022July 31, 2026TAI, LEON MAINGreporter.nih.gov
Marmosets as a Model for Understanding Social, Neuroendocrine, and Vascular Contributions to Cognitive AgingNIHNational Institute on Aging2021 to 2023$804,994August 1, 2019April 30, 2025PHILLIPS, KIMBERLEY ANNreporter.nih.gov
Dysfunction of brain microvascular and lymphatic vessels in obesity-linked cognitive impairmentNIHNational Institute on Aging2025$801,348June 1, 2025February 28, 2030SMITH, WANLI Wreporter.nih.gov
Targeting cerebrovascular Wnt/beta-catenin signaling to reverse brain endothelial damage induced by SARS-CoV-2 infectionNIHNational Institute of Neurological Disorders and Stroke2025$801,329December 1, 2024November 30, 2029LUTZ, SARAH ELIZABETHreporter.nih.gov
Vascular dysfunction in glaucomaNIHNational Eye Institute2022 to 2023$797,500April 1, 2022March 31, 2027MUIR, ERIC RAYMONDreporter.nih.gov
Blood-brain barrier and microstructural brain biomarkers of ARIA and treatment outcomes with anti-amyloid immunotherapy for Alzheimer's diseaseNIHNational Institute on Aging2025$794,981January 1, 2025December 31, 2029REAS, EMILIE T.reporter.nih.gov
Age-related Hypertension and Vascular Cognitive ImpairmentNIHNational Institute on Aging2024$793,084February 1, 2022January 31, 2027WAINFORD, RICHARD DAVIDreporter.nih.gov
Computational Speech Analysis in Alzheimer's Disease and Other Neurocognitive DisordersNIHNational Institute on Aging2021 to 2024$791,456May 1, 2020April 30, 2026PRESSMAN, PETER SCOTTreporter.nih.gov
High-Speed Imaging of Cortical and White Matter Microvascular Flow in AD/ADRD ModelsNIHNational Institute of Neurological Disorders and Stroke2025$791,262August 15, 2022July 31, 2027SCHAFFER, CHRIS Breporter.nih.gov
Blood-brain barrier dysfunction in Alzheimer's disease: from humans to animal modelsNIHNational Institute on Aging2024$788,363May 1, 2021April 30, 2027LU, HANZHANGreporter.nih.gov
Systemic and dietary advanced glycation end products in type 2 diabetes-related cognitive decline and incident dementia: effects on Alzheimer's pathology and cerebrovascular diseaseNIHNational Institute on Aging2024$787,175July 18, 2023November 30, 2025SCHNAIDER BEERI, MICHALreporter.nih.gov
Vascular Mechanisms of Dementia: Cell-Type Specific Therapeutic and Imaging StrategiesNIHNational Institute of Neurological Disorders and Stroke2025$784,245July 1, 2022June 30, 2027GRUTZENDLER, JAIMEreporter.nih.gov
Brain cPLA2 as a mechanism for neuroinflammation in AD/ADRD with and without APOE4NIHNational Institute on Aging2025$780,961May 15, 2022April 30, 2027YASSINE, HUSSEIN Nreporter.nih.gov
B Cells Directly Alter Adaptive Plasticity to Support Functional Recovery After StrokeNIHNational Institute of Neurological Disorders and Stroke2024 to 2025$779,321February 1, 2015June 30, 2027STOWE, ANN MARIEreporter.nih.gov
Perivascular Inflammation and Vascular Remodeling: A Common Cause of Hemorrhage in Cerebral Small Vessel Diseases?NIHNational Institute of Neurological Disorders and Stroke2023$776,503August 1, 2023July 31, 2025VAN VELUW, SUSANNE JANNEKEreporter.nih.gov
Quantitative cerebral blood vessel imaging biomarkers for AD and VCIDNIHNational Institute on Aging2025$775,949April 1, 2021March 31, 2027YAN, LIRONGreporter.nih.gov
Endothelial protocadherins in vascular development and diseaseNIHNational Heart, Lung, and Blood Institute2025$775,720August 15, 2025May 31, 2029SCHWARTZ, MARTIN Areporter.nih.gov
Endothelial cell senescence and APOE4 in vascular cognitive impairment and dementiaNIHNational Institute on Aging2024 to 2025$774,675March 15, 2021February 28, 2026KANEKIYO, TAKAHISAreporter.nih.gov
Role of Sox18 in neurovascular dysfunction in Alzheimer's diseaseNIHNational Institute on Aging2025$772,581January 1, 2025November 30, 2029DANEMAN, RICHARDreporter.nih.gov
Mechanistic and Functional Evaluation of a Model of Cerebral Small Vessel DiseaseNIHNational Institute of Neurological Disorders and Stroke2025$770,502May 1, 2025April 30, 2030GOULD, DOUGLASreporter.nih.gov
Lifespan Vascular Biology on White MatterNIHNational Institute of Neurological Disorders and Stroke2024$770,374August 15, 2020August 14, 2025MITCHELL, BRAXTON Dreporter.nih.gov
Repurposing of R-etodolac for Alzheimer's disease and related disordersNIHNational Institute of Neurological Disorders and Stroke2025$768,262September 1, 2023August 31, 2027KHALIL KADDOUMI, AMAL Freporter.nih.gov
Mechanism of ARIA following Anti-Amyloid ImmunotherapyNIHNational Institute on Aging2025$766,133January 1, 2025November 30, 2029URAYAMA, AKIHIKOreporter.nih.gov
STAT3 activation in astrocytes as a driver of neurovascular dysfunction in Alzheimer's disease and related dementiasNIHNational Institute of Neurological Disorders and Stroke2025$765,645September 19, 2022August 31, 2027LIPPMANN, ETHANreporter.nih.gov
Brain Drain: In Vivo Optical Interrogation of Venular Function in Gray and White MatterNIHNational Institute on Aging2025$762,178May 15, 2022April 30, 2027SHIH, ANDY Yreporter.nih.gov
Longitudinal transdisciplinary Neuropalliative care Support for Patients with Severe Stroke and their FamiliesNIHNational Institute on Aging2024$761,403August 15, 2024July 31, 2026CREUTZFELDT, CLAIRE JOHANNAreporter.nih.gov

Organizations

OrganizationPlaceNIH awardsNIH amountNSF awardsNSF amount
Columbia University Health SciencesNew York, NY22$179.5 million0$0
University of Wisconsin-MadisonMadison, WI14$141.4 million0$0
Massachusetts General HospitalBoston, MA35$73 million0$0
University of Pittsburgh at PittsburghPittsburgh, PA36$65.5 million0$0
University of California at DavisDavis, CA10$59 million0$0
Johns Hopkins UniversityBaltimore, MD25$58.5 million0$0
Vanderbilt University Medical CenterNashville, TN9$56.9 million0$0
University of Southern CaliforniaLos Angeles, CA19$54.2 million0$0
Wake Forest University Health SciencesWinston-Salem, NC12$50.5 million0$0
Rush University Medical CenterChicago, IL11$50.2 million0$0
University of California, San DiegoLa Jolla, CA14$46.1 million0$0
University of South FloridaTampa, FL7$41.6 million0$0
New York University School of MedicineNew York, NY10$36.8 million0$0
Tulane University of LouisianaNew Orleans, LA9$34.6 million0$0
University of Texas HLTH Science CenterSan Antonio, TX8$32.9 million0$0
University of California, San FranciscoSan Francisco, CA17$32.1 million0$0
University of Miami School of MedicineCoral Gables, FL11$28.9 million0$0
Northwestern University at ChicagoChicago, IL13$28.3 million0$0
University of California-BerkeleyBerkeley, CA3$27.2 million0$0
Boston University Medical CampusBoston, MA15$24.4 million0$0
University of KentuckyLexington, KY14$23.1 million0$0
University of Alabama at BirminghamBirmingham, AL6$23 million0$0
University of ArizonaTucson, AZ8$22.8 million0$0
University of CincinnatiCincinnati, OH6$22.3 million0$0
Duke UniversityDurham, NC11$22.2 million0$0
University of Vermont & ST Agric CollegeBurlington, VT9$21.3 million0$0
Brigham and Women's HospitalBoston, MA8$21.1 million0$0
University of California-IrvineIrvine, CA11$20.9 million0$0
University of PennsylvaniaPhiladelphia, PA11$20.6 million0$0
University of Michigan at Ann ArborAnn Arbor, MI11$19.3 million0$0
Emory UniversityAtlanta, GA7$18.9 million0$0
Washington UniversitySaint Louis, MO8$18.5 million0$0
Mayo Clinic RochesterRochester, MN7$17.9 million0$0
Albert Einstein College of MedicineBronx, NY4$15.6 million0$0
Weill Medical Coll of Cornell UnivNew York, NY7$15.2 million0$0
Oregon Health & Science UniversityPortland, OR11$14.9 million0$0
University of Texas HLTH Sci CTR HoustonHouston, TX13$14.7 million0$0
SUNY Downstate Medical CenterBrooklyn, NY1$14.1 million0$0
Icahn School of Medicine at Mount SinaiNew York, NY6$14.1 million0$0
Yale UniversityNew Haven, CT13$13.6 million0$0
University of New Mexico Health Scis CTRAlbuquerque, NM4$12.9 million0$0
SUNY at Stony BrookStony Brook, NY6$12.7 million0$0
Chapman UniversityOrange, CA1$12.7 million0$0
University of MinnesotaMinneapolis, MN7$11.8 million0$0
Vanderbilt UniversityNashville, TN10$11.7 million0$0
Ut Southwestern Medical CenterDallas, TX3$11.5 million0$0
University of Colorado DenverAurora, CO9$11.2 million0$0
Massachusetts Institute of TechnologyCambridge, MA6$10.4 million0$0
University of Oklahoma HLTH Sciences CTROklahoma City, OK10$9.8 million0$0
University of RochesterRochester, NY7$9.7 million0$0
Board of Regents, NSHE, obo University of Nevada, RenoReno, NV4$9.6 million0$0
Regenerative Research FoundationAlbany, NY2$8.9 million0$0
Stanford UniversityStanford, CA9$8.8 million0$0
Indiana University IndianapolisIndianapolis, IN8$8.6 million0$0
University of California Los AngelesLos Angeles, CA5$8.4 million0$0
University of Illinois at ChicagoChicago, IL9$8.4 million0$0
Jackson LaboratoryBar Harbor, ME4$8.1 million0$0
Cleveland Clinic Lerner Com-CwruCleveland, OH2$8 million0$0
Pennsylvania State Univ University ParkUniversity Park, PA1$7.9 million0$0
J. David Gladstone InstitutesSan Francisco, CA2$7.7 million0$0
Medical University of South CarolinaCharleston, SC4$7.2 million0$0
Augusta UniversityAugusta, GA6$6.9 million0$0
University of WashingtonSeattle, WA4$6.6 million0$0
Rutgers Biomedical and Health SciencesNewark, NJ5$6.5 million0$0
University of UtahSalt Lake City, UT2$6.3 million0$0
LSU Pennington Biomedical Research CTRBaton Rouge, LA2$6.2 million0$0
University of FloridaGainesville, FL6$6.1 million0$0
Washington State UniversityPullman, WA2$6.1 million0$0
Cornell UniversityIthaca, NY3$5.7 million0$0
Hugo W. Moser Res Inst Kennedy KriegerBaltimore, MD3$5.6 million0$0
University of TX MD Anderson Can CTRHouston, TX2$5.4 million0$0
Beth Israel Deaconess Medical CenterBoston, MA4$5.1 million0$0
Seattle Children's HospitalSeattle, WA4$4.9 million0$0
Henry Ford Health + Michigan State University Health SciencesEast Lansing, MI3$4.7 million0$0
Univ of North Carolina Chapel HillChapel Hill, NC3$4.6 million0$0
Tufts Medical CenterBoston, MA2$4.6 million0$0
University of EdinburghEdinburgh2$4.5 million0$0
University of New South WalesSydney1$4.4 million0$0
University of VirginiaCharlottesville, VA3$4.3 million0$0
University of Maryland BaltimoreBaltimore, MD4$4.3 million0$0
Ohio State UniversityColumbus, OH4$4.2 million0$0
Magee-Women's Res Inst and FoundationPittsburgh, PA1$4 million0$0
Aromha, Inc.Potomac, MD1$3.7 million0$0
Pennsylvania State Univ Hershey Med CTRHershey, PA2$3.7 million0$0
University of Connecticut SCH of Med/dntFarmington, CT3$3.7 million0$0
Rockefeller UniversityNew York, NY1$3.4 million0$0
Trustees of Boston UniversityBoston, MA2$3.3 million0$0
Cedars-Sinai Medical CenterLos Angeles, CA1$3.1 million0$0
Therini Bio, Inc.Sacramento, CA1$3 million0$0
Evon Medics, LLCElkridge, MD1$2.9 million0$0
Gen-9, Inc.Mountain View, CA1$2.9 million0$0
West Virginia University Research CorporationMorgantown, WV3$2.8 million0$0
Albany Medical CollegeAlbany, NY1$2.7 million0$0
Loma Linda UniversityLoma Linda, CA1$2.7 million0$0
North Dakota State University FargoFargo, ND2$2.6 million0$0
Florida International UniversityMiami, FL1$2.6 million0$0
Rhode Island HospitalProvidence, RI1$2.6 million0$0
Together Senior Health, Inc.New York, NY1$2.5 million0$0
Neuroscope Inc.Scarsdale, NY1$2.4 million0$0
ST. Joseph's Hospital and Medical CenterPhoenix, AZ2$2.4 million0$0

Funding by fiscal year

Fiscal yearNIH awardsNIH amountNSF awardsNSF amount
2025479$456,863,6200$0
2024494$497,599,2380$0
2023468$480,414,5820$0
2022289$288,343,7100$0
2021193$225,247,2200$0

Open federal funding opportunities

From Grants.gov: notices that funded awards in this table, and open notices on the same agency and assistance listing.

Open opportunityNumberAgencyListingClosesAward ceilingWhy it matches
Change of Recipient Organization (Type 7 Parent Clinical Trial Optional)PA-24-254NIHJuly 12, 2027Not listedNotice number printed on 9 awards here
Mentored Clinical Scientist Research Career Development Award (Parent K08 Independent Clinical Trial Not Allowed)PA-24-182NIHMay 8, 2027Not listedNotice number printed on 1 award here
Mentored Patient-Oriented Research Career Development Award (Parent K23 Independent Clinical Trial Not Allowed)PA-24-185NIHMay 7, 2027Not listedNotice number printed on 1 award here
Secondary Analysis and Integration of Existing Data to Elucidate Cancer Risk and Related Outcomes (R01 Clinical Trial Not Allowed)PAR-25-095NIH93.866November 6, 2026$350,000Same assistance listing 93.866 as 468 awards here
Data Coordinating Center for the Aging and Alzheimer’s Disease Mouse Brain Atlas (AD-MBA) (U24 Clinical Trial Not Allowed)RFA-AG-27-010NIH93.866November 10, 2026Not listedSame assistance listing 93.866 as 468 awards here
Secondary Analysis and Integration of Existing Data to Elucidate Cancer Risk and Related Outcomes (R21 Clinical Trials Not Allowed)PAR-25-096NIH93.866November 17, 2026$200,000Same assistance listing 93.866 as 468 awards here
HEAL Initiative: Pain Research Enhancement Program (PREP) (R15 Clinical Trial Optional)RFA-AT-25-003NIH93.866November 23, 2026$375,000Same assistance listing 93.866 as 468 awards here
Competing Revisions to Existing NIH Single Project Research Grants and Cooperative Agreements (Clinical Trial Optional)PA-23-317NIH93.866November 24, 2026Not listedSame assistance listing 93.866 as 468 awards here
Emerging Global Leader Award (K43 Independent Clinical Trial Required)PAR-24-295NIH93.866December 3, 2026Not listedSame assistance listing 93.866 as 468 awards here
Emerging Global Leader Award (K43 Independent Clinical Trial Not Allowed)PAR-24-296NIH93.866December 3, 2026Not listedSame assistance listing 93.866 as 468 awards here
NIH Research Software Engineer (RSE) Award (R50 Clinical Trials Not Allowed)RFA-OD-24-011NIH93.866December 4, 2026Not listedSame assistance listing 93.866 as 468 awards here
Small Business Transition Grant for New Entrepreneurs (Parent R43/R44 Clinical Trial Optional)PAR-27-039NIH93.866January 5, 2027Not listedSame assistance listing 93.866 as 468 awards here
Small Business Transition Grant for New Entrepreneurs (Parent R41/R42 Clinical Trial Optional)PAR-27-040NIH93.866January 5, 2027Not listedSame assistance listing 93.866 as 468 awards here
Academic Research Enhancement Award (AREA) for Undergraduate-Focused Institutions (R15 Clinical Trial Required)PAR-24-214NIH93.866January 7, 2027$375,000Same assistance listing 93.866 as 468 awards here
Intervention Research to Improve Native American Health (R34 Clinical Trial Optional)PAR-25-378NIH93.866January 7, 2027Not listedSame assistance listing 93.866 as 468 awards here
Intervention Research to Improve Native American Health (R01 Clinical Trial Optional)PAR-25-379NIH93.866January 7, 2027Not listedSame assistance listing 93.866 as 468 awards here
HEAL Initiative: Studies to Enable Analgesic Discovery (R61/R33 - Clinical Trial Not Allowed)RFA-NS-25-023NIH93.866January 15, 2027$350,000Same assistance listing 93.866 as 468 awards here
Precision and Systems Biology to Uncover the Link Between Chronic and Infectious DiseasesRFA-AI-28-014NIH93.866January 22, 2027Not listedSame assistance listing 93.866 as 468 awards here
HEAL Initiative: Integrative Management of Chronic Pain and OUD for Whole Recovery (IMPOWR): Research Centers (RM1 Clinical Trial Required)RFA-DA-28-011NIH93.866January 26, 2027Not listedSame assistance listing 93.866 as 468 awards here
HEAL Initiative: Integrative Management of chronic Pain and OUD for Whole Recovery (IMPOWR) - Building Engagement, Assistance, Capacity, Outreach, and Networks (BEACON) Center (U2C Clinical Trial Not Allowed)RFA-DA-28-012NIH93.866January 26, 2027Not listedSame assistance listing 93.866 as 468 awards here

Updated November 4, 2026. Read from NIH RePORTER ExPORTER and NSF Award Search. Published by NIH and NSF as U.S. government data. NIH awards are fiscal years 2021 to 2025 (NIH files published to 2026-07-09); NSF awards are fiscal years 2022 to 2026 (NSF files published to 2026-11-04). NIH amounts are the total cost of each fiscal year in the window; NSF amounts are the funds obligated in the window. Organizations are matched on the UEI. Open opportunities come from Grants.gov and match on agency and assistance listing number, and on the notice number NIH prints on an award. Free to reuse with credit to SpecStream under CC BY 4.0. Spot a wrong value? Write to [email protected] with the link to this page.