Data / Research funding / Polycystic Kidney Disease
Polycystic Kidney Disease: 163 NIH awards ($164.7M) to 65 organizations
163 NIH awards ($164.7M) in the NIH spending category Polycystic Kidney Disease, to 65 organizations, read 2026-11-03. NIH fiscal years 2021 to 2025.
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163 awards in the window.
| Award | Agency | Institute or division | Fiscal year | Amount in window | Start | End | Principal investigator | Source |
|---|---|---|---|---|---|---|---|---|
| Central Coordinating Site for the Polycystic Kidney Disease (PKD) Research Core Centers | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2021 to 2025 | $4,824,202 | July 20, 2020 | August 31, 2030 | WATNICK, TERRY J | reporter.nih.gov |
| Maryland Polycystic Kidney Disease Research Core Center (MPKD-RCC) | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2021 to 2025 | $4,654,991 | August 24, 2020 | August 31, 2030 | WATNICK, TERRY J | reporter.nih.gov |
| UAB Childhood Cystic Kidney Disease Center (UAB-CCKDC) | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2021 to 2025 | $4,330,298 | July 20, 2020 | August 31, 2030 | YODER, BRADLEY K. | reporter.nih.gov |
| In vivo Pathway Discovery in Autosomal Dominant Polycystic Kidney Disease | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2021 to 2023 | $3,867,356 | September 9, 2019 | June 30, 2025 | SOMLO, STEFAN | reporter.nih.gov |
| ADPKD: Disease Spectrum & Genotype-Phenotype Correlations | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2021 to 2025 | $3,092,802 | August 1, 2001 | May 31, 2028 | HARRIS, PETER C. | reporter.nih.gov |
| Novel role of urinary urate in renal cystogenesis and water regulation | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2025 | $2,967,657 | September 1, 2025 | August 31, 2029 | CHEBIB, FOUAD T | reporter.nih.gov |
| Investigation of common disease mechanisms in nonsyndromic and syndromic PKD | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2021 to 2025 | $2,712,900 | April 15, 2002 | December 31, 2026 | HARRIS, PETER C. | reporter.nih.gov |
| Biomechanical drivers of cystogenesis | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2021 to 2024 | $2,696,798 | September 24, 2021 | July 31, 2025 | GUSELLA, GABRIELE LUCA | reporter.nih.gov |
| Daily Caloric Restriction in Overweight and Obese Adults with ADPKD | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2021 to 2025 | $2,687,567 | July 1, 2021 | May 31, 2027 | NOWAK, KRISTEN LYNN | reporter.nih.gov |
| A comprehensive map of polycystin channel regulation and its implications in polycystic kidney disease | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2021 to 2024 | $2,672,628 | September 15, 2021 | July 31, 2025 | DELLING, MARKUS G | reporter.nih.gov |
| Cell polarity and morphogenesis in Xenopus embryos | NIH | National Institute of General Medical Sciences | 2021 to 2025 | $2,595,273 | August 1, 2017 | June 30, 2027 | SOKOL, SERGEI | reporter.nih.gov |
| Polycystins, cilia, and extracellular vesicles in C. elegans | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2021 to 2025 | $2,467,492 | May 1, 2001 | June 30, 2027 | BARR, MAUREEN M | reporter.nih.gov |
| Role of homocysteine metabolism, endothelial function and microvascular rarefaction on renal disease severity and progression in ADPKD | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2021 to 2024 | $2,449,537 | May 1, 2021 | March 31, 2026 | IRAZABAL, MARIA V | reporter.nih.gov |
| PKD proteins in endothelial cells | NIH | National Heart, Lung, and Blood Institute | 2021 to 2024 | $2,397,306 | February 15, 2021 | January 31, 2026 | JAGGAR, JONATHAN H | reporter.nih.gov |
| Role of primary cilium-generated signaling in polycystic kidney disease | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2022 to 2025 | $2,373,193 | January 15, 2022 | November 30, 2026 | MUKHOPADHYAY, SAIKAT | reporter.nih.gov |
| Intraflagellar Transport Proteins in Mice | NIH | National Institute of General Medical Sciences | 2021 to 2025 | $2,358,960 | June 1, 2001 | January 31, 2027 | PAZOUR, GREGORY J | reporter.nih.gov |
| Kidney Stone Disease In ADPKD | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2021 to 2025 | $2,353,533 | September 22, 2021 | June 30, 2027 | CHONCHOL, MICHEL BENJAMIN | reporter.nih.gov |
| Safety and Efficacy of Human Clinical Trials Using Kidney-on-a-Chip Microphysiological Systems | NIH | National Center for Advancing Translational Sciences | 2022 to 2024 | $2,334,876 | July 15, 2020 | June 30, 2026 | FREEDMAN, BENJAMIN SOLOMON | reporter.nih.gov |
| Modulation of cystogenesis | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2022 to 2025 | $2,324,556 | May 1, 2022 | February 28, 2027 | ZHOU, JING | reporter.nih.gov |
| NPHP2 in ciliary function, renal fibrosis and cyst formation | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2021 to 2025 | $2,168,386 | September 15, 2017 | April 30, 2027 | SUN, ZHAOXIA | reporter.nih.gov |
| PKD1 derepression as a potential therapy for Polycystic Kidney Disease | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2022 to 2025 | $2,160,777 | September 1, 2022 | May 31, 2027 | PATEL, VISHAL | reporter.nih.gov |
| Ion Channel Function and Regulation of the Polycystin-1/2 Complex in Kidney Physiology and Polycystic Kidney Disease | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2021 to 2024 | $2,154,216 | July 1, 2020 | May 31, 2026 | QIAN, FENG | reporter.nih.gov |
| Dissecting and targeting lysosomal signaling in kidney tumorigenesis | NIH | National Cancer Institute | 2022 to 2025 | $2,144,296 | March 21, 2022 | February 28, 2027 | ZONCU, ROBERTO | reporter.nih.gov |
| Nephronophthisis-related ciliopathies and ciliary specialization | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2021 to 2025 | $2,071,959 | February 15, 2023 | December 31, 2026 | BARR, MAUREEN M | reporter.nih.gov |
| Molecular Mechanisms Regulating Epithelial Cell Apical Polarity and Ciliogenesis | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2021 to 2025 | $2,046,879 | January 15, 2004 | June 30, 2028 | PREKERIS, RYTIS | reporter.nih.gov |
| Identification of new therapeutic targets for ADPKD | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2021 to 2024 | $2,012,444 | September 1, 2021 | June 30, 2025 | SKOLNIK, EDWARD Y | reporter.nih.gov |
| Injury Response Mediated Pathogenesis in Renal Ciliopathies | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2021 to 2025 | $1,950,967 | February 1, 2023 | November 30, 2026 | YODER, BRADLEY K. | reporter.nih.gov |
| The crosstalk of DNA and lysine methyltransferases in ADPKD. | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2021 to 2024 | $1,917,952 | September 15, 2020 | July 31, 2026 | LI, XIAOGANG | reporter.nih.gov |
| ADPKD: Understanding immunosuppression mechanisms and discovering treatment | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2021 to 2024 | $1,841,779 | September 1, 2021 | June 30, 2025 | LI, XIAOGANG | reporter.nih.gov |
| Molecular and cellular basis of the renal diseases associated with Alagille Syndrome | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2021 to 2025 | $1,811,392 | May 1, 2021 | February 28, 2027 | SURENDRAN, KAMESWARAN | reporter.nih.gov |
| Ketosis as a therapy for polycystic kidney disease | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2021 to 2024 | $1,790,657 | April 1, 2020 | January 31, 2026 | WEIMBS, THOMAS | reporter.nih.gov |
| Regulation of Kidney-Specific Gene Expression | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2022 to 2025 | $1,731,451 | November 18, 2022 | June 30, 2027 | IGARASHI, PETER | reporter.nih.gov |
| The impact of RNA chemical modifications on polycystic kidney disease progression | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2021 to 2024 | $1,686,633 | May 11, 2015 | December 31, 2025 | PATEL, VISHAL | reporter.nih.gov |
| Impact of Phosphaturia on Renal Osteopontin Production and PKD Progression | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2021 to 2024 | $1,647,056 | September 23, 2021 | July 31, 2025 | STUBBS, JASON | reporter.nih.gov |
| Mechanisms driving cardiac dysfunction in Autosomal Dominant Polycystic Kidney Disease | NIH | National Heart, Lung, and Blood Institute | 2022 to 2025 | $1,615,000 | May 15, 2022 | April 30, 2027 | ALTAMIRANO, FRANCISCO | reporter.nih.gov |
| Cilia calcium dysregulation in polycystic kidney disease | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2022 to 2025 | $1,592,249 | September 1, 2022 | May 31, 2027 | DECAEN, PAUL GREGORY | reporter.nih.gov |
| Pannexin-1/P2X7 interaction promotes excessive ATP release in kidney cysts and ADPKD progression via reduced NaCl reabsorption | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2021 to 2024 | $1,581,990 | June 3, 2021 | April 30, 2026 | PAVLOV, TENGIS S | reporter.nih.gov |
| Mechanisms of immunosuppression in the development and progression of renal disease in Tuberous Sclerosis Complex | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2023 to 2025 | $1,569,410 | April 5, 2023 | March 31, 2028 | HENSKE, ELIZABETH P | reporter.nih.gov |
| Molecular Basis of Hair Cell Stereocilia Bundle Morphology | NIH | National Institute on Deafness and Other Communication Disorders | 2021 to 2022 | $1,559,148 | August 1, 2018 | July 31, 2024 | INDZHYKULIAN, ARTUR | reporter.nih.gov |
| Decoding reno-protective mechanisms in mouse Pkhd1 models: Implications for ARPKD therapeutics | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2021 to 2024 | $1,555,092 | July 1, 2020 | April 30, 2026 | CALDOVIC, LJUBICA MORIZONO | reporter.nih.gov |
| Dissecting the Diverse Roles of Importin α at the Plasma Membrane | NIH | National Institute of General Medical Sciences | 2022 to 2025 | $1,554,644 | August 1, 2022 | July 31, 2027 | BROWNLEE, CHRISTOPHER WILLIAM | reporter.nih.gov |
| Molecular dissection of the ciliary gate | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2021 to 2025 | $1,550,746 | August 15, 2014 | November 30, 2028 | HU, JINGHUA | reporter.nih.gov |
| Imaging Assessments of ARPKD Kidney Disease Progression | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2021 to 2025 | $1,546,644 | August 20, 2019 | February 28, 2029 | DELL, KATHERINE MACRAE | reporter.nih.gov |
| Cross talk between epithelial, inflammatory and mesenchymal cells in the development of portal fibrosis | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2021 to 2023 | $1,522,465 | May 1, 2015 | August 31, 2024 | STRAZZABOSCO, MARIO | reporter.nih.gov |
| Developing a New Therapeutic Approach for Autosomal Dominant Polycystic Kidney Disease. | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2021 to 2024 | $1,426,590 | July 1, 2020 | May 31, 2026 | CEBOTARU, LIUDMILA | reporter.nih.gov |
| Extracellular protease modulation of the cilium transition zone in kidney development and disease | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2022 to 2025 | $1,422,410 | January 1, 2022 | December 31, 2026 | NANDADASA, SUMEDA | reporter.nih.gov |
| Polycystin Dependent Mechanisms of Tubular Plasticity | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2021 to 2023 | $1,420,815 | September 1, 2019 | June 30, 2025 | SOMLO, STEFAN | reporter.nih.gov |
| Ciliary Disassembly, a modifier of Autosomal Dominant Polycystic Kidney Disease | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2021 to 2024 | $1,410,976 | March 15, 2021 | January 31, 2026 | TSIOKAS, LEONIDAS | reporter.nih.gov |
| Pathogenic reciprocal interplay between cyst epithelium and myofibroblasts in polycystic kidney disease | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2023 to 2025 | $1,405,970 | February 1, 2023 | November 30, 2026 | RAO, REENA | reporter.nih.gov |
| Advancing ADPKD Treatment with GLP-1RA: A Study of Glucagon-Like Peptide-1 Receptor Agonists' Efficacy, Safety, and Mechanism | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2024 to 2025 | $1,370,843 | August 15, 2024 | May 31, 2029 | NOWAK, KRISTEN LYNN | reporter.nih.gov |
| Structural Mechanisms of Polycystic Kidney Disease Proteins | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2024 to 2025 | $1,348,334 | July 22, 2024 | April 30, 2028 | CAO, ERHU | reporter.nih.gov |
| Kidney Tubular Damage and Dysfunction in Autosomal Dominant Polycystic Kidney Disease | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2024 to 2025 | $1,339,274 | June 1, 2024 | March 31, 2028 | GARIMELLA, PRANAV | reporter.nih.gov |
| Molecular modulators of polycystin signaling | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2021 to 2023 | $1,338,874 | March 1, 2019 | January 31, 2025 | SOMLO, STEFAN | reporter.nih.gov |
| Human-specific Abnormal Alternative Splicing of the Wild-type PKD1 Gene Induces Premature Termination of Polycystin-1 | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2021 to 2024 | $1,332,936 | September 15, 2020 | July 31, 2025 | WARD, CHRISTOPHER J | reporter.nih.gov |
| Screening for modifiers of PKD severity using ENU Mutagenesis | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2021 to 2022 | $1,263,682 | September 19, 2018 | July 31, 2024 | BEIER, DAVID R. | reporter.nih.gov |
| Targeting kidney resident macrophage niche filling to slow cystic kidney disease | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2022 to 2025 | $1,256,183 | September 15, 2022 | June 30, 2027 | ZIMMERMAN, KURT A | reporter.nih.gov |
| The mechanism of cell size regulation by polycystins | NIH | National Institute of General Medical Sciences | 2022 to 2025 | $1,254,880 | April 15, 2022 | March 31, 2027 | CHEN, QIAN | reporter.nih.gov |
| Tissue Chip Data to the Microphysiology Systems Database (MPS-Db) Supplement to A Microphysiological System for Kidney Disease Modeling and Drug Efficacy Testing | NIH | National Center for Advancing Translational Sciences | 2021 | $1,250,569 | July 25, 2017 | June 30, 2023 | HIMMELFARB, JONATHAN | reporter.nih.gov |
| Metabolic reprogramming and FGF21 signaling in kidney health and polycystic kidney diseases | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2023 to 2025 | $1,219,151 | December 18, 2023 | June 30, 2027 | DAI, DAO-FU | reporter.nih.gov |
| Modeling genetic contributions to biliary atresia | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2024 to 2025 | $1,197,376 | June 15, 2023 | April 30, 2027 | KARPEN, SAUL J. | reporter.nih.gov |
| Transition zone control of ciliary signaling | NIH | National Institute of Dental & Craniofacial Research | 2021 to 2022 | $1,184,783 | July 18, 2011 | August 31, 2023 | REITER, JEREMY F | reporter.nih.gov |
| The Role of Wheat-Gluten in Polycystic Kidney Disease | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2022 to 2025 | $1,175,661 | September 21, 2022 | June 30, 2027 | SAIGUSA, TAKAMITSU | reporter.nih.gov |
| Molecular dysregulation of primary cilia TRPP2 channels caused by Finger 1 variants | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2021 to 2023 | $1,136,005 | September 3, 2019 | July 31, 2024 | DECAEN, PAUL GREGORY | reporter.nih.gov |
| Pathobiology of Hepatic Epithelia | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2021 to 2023 | $1,073,250 | December 1, 1978 | March 31, 2024 | LARUSSO, NICHOLAS F. | reporter.nih.gov |
| Functional characterization of a novel key regulator of the distal nephron whose deficiency leads to renal fibrosis and cyst formation | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2021 to 2023 | $1,049,616 | December 17, 2018 | November 30, 2024 | MARNEROS, ALEXANDER GEORG | reporter.nih.gov |
| Trafficking and Sorting Mechanisms of Golgi Vesicles to Cilia | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2021 to 2023 | $1,043,820 | July 1, 2020 | April 30, 2025 | TAKEMARU, KEN-ICHI | reporter.nih.gov |
| Investigate the trafficking and function of polycystins in primary cilia and their implications for polycystic kidney disease | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2024 to 2025 | $1,032,322 | April 1, 2024 | January 31, 2028 | LING, KUN | reporter.nih.gov |
| Kidney Microphysiological Analysis Platforms (MAP) to Optimize Function and Model Disease | NIH | National Center for Advancing Translational Sciences | 2021 | $1,006,126 | July 25, 2017 | June 30, 2024 | BONVENTRE, JOSEPH VINCENT | reporter.nih.gov |
| Understanding Polycystin-1 Structure-GPCR Function for the Development of New Therapeutic Approaches in ADPKD | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2021 to 2023 | $1,000,938 | January 15, 2020 | November 30, 2024 | MASER, ROBIN LEE | reporter.nih.gov |
| Cyst induction and growth in ADPKD | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2024 to 2025 | $981,736 | August 15, 2024 | May 31, 2029 | CEBRIAN LIGERO, CRISTINA | reporter.nih.gov |
| Differentiating slow from rapidly progressive ADPKD by cell-specific mitochondrial and transcriptional profiles | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2024 to 2025 | $981,084 | April 1, 2024 | January 31, 2029 | LASSEIGNE, BRITTANY NICOLE | reporter.nih.gov |
| Role of FBW7 in cystic diseases of the kidney | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2024 to 2025 | $973,272 | August 15, 2024 | May 31, 2028 | TSIOKAS, LEONIDAS | reporter.nih.gov |
| Pattern formation and function of PKD2/polycystin-2 in motile cilia | NIH | National Institute of General Medical Sciences | 2021 to 2023 | $906,000 | September 18, 2020 | July 31, 2024 | LECHTRECK, KARL | reporter.nih.gov |
| Safety and Efficacy of Human Clinical Trials Using Kidney-on-a-Chip Microphysiological Systems | NIH | National Center for Advancing Translational Sciences | 2021 | $875,910 | July 15, 2020 | July 31, 2022 | HIMMELFARB, JONATHAN | reporter.nih.gov |
| Feasibility study of empagliflozin in patients with autosomal dominant polycystic kidney disease | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2022 to 2024 | $874,309 | August 15, 2022 | July 31, 2025 | CHONCHOL, MICHEL BENJAMIN | reporter.nih.gov |
| In vivo investigation of PKD1 upstream open reading frames as a therapeutic target in autosomal dominant polycystic kidney disease | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2024 to 2025 | $853,472 | December 15, 2023 | November 30, 2028 | BESSE, WHITNEY ELISE | reporter.nih.gov |
| Targeting Myosin to Treat Polycystic Kidney Disease | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2025 | $839,264 | April 12, 2023 | June 30, 2028 | FREEDMAN, BENJAMIN SOLOMON | reporter.nih.gov |
| A Model for Human Liver Fibrosis | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2022 | $772,327 | September 1, 2022 | August 31, 2025 | PELTZ, GARY A | reporter.nih.gov |
| Defective flow-dependent tubule transport in the pathogenesis of kidney disease | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2021 to 2022 | $754,089 | February 1, 2019 | November 30, 2023 | WANG, TONG WANG | reporter.nih.gov |
| QSM for detection of hemorrhaging cysts and risk stratification in ADPKD | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2025 | $728,513 | January 20, 2025 | November 30, 2029 | DIMOV, ALEXEY | reporter.nih.gov |
| A Human Organoid Model of Polycystic Kidney Disease | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2021 to 2022 | $706,000 | September 15, 2018 | June 30, 2023 | FREEDMAN, BENJAMIN SOLOMON | reporter.nih.gov |
| Genetic dissection of ciliary ARL13B in kidney cystogenesis | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2022 to 2024 | $688,325 | September 15, 2022 | June 30, 2025 | CASPARY, TAMARA J. | reporter.nih.gov |
| AKAP Modulation of Renal Signaling | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2021 to 2022 | $681,874 | July 1, 2019 | May 31, 2024 | SCOTT, JOHN D | reporter.nih.gov |
| Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP) IV: Prognosis for End-Stage Renal Disease and Biomarker Validation | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2021 | $674,302 | April 1, 2017 | March 30, 2023 | YU, ALAN S | reporter.nih.gov |
| Polycystin-1 C terminal tail cleavage: Mechanisms and meaning | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2025 | $640,001 | January 1, 2025 | November 30, 2028 | CAPLAN, MICHAEL J. | reporter.nih.gov |
| Mechanisms of Signaling Protein Retention in the Primary Cilium | NIH | National Institute of General Medical Sciences | 2021 to 2022 | $626,000 | May 24, 2019 | March 31, 2024 | JIANG, YU | reporter.nih.gov |
| Regulation of Kidney-Specific Gene Expression | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2021 to 2022 | $623,434 | April 15, 1991 | March 31, 2023 | IGARASHI, PETER | reporter.nih.gov |
| Molecular genetic bases of polycystic and tubulointerstitial kidney diseases | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2021 to 2023 | $601,785 | June 1, 2019 | October 31, 2024 | BESSE, WHITNEY ELISE | reporter.nih.gov |
| Renal Denervation to Treat Polycystic Kidney Disease: Mechanisms and Mediators | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2024 | $600,159 | December 15, 2023 | November 30, 2024 | BANEK, CHRISTOPHER T | reporter.nih.gov |
| Renal Denervation to Treat Polycystic Kidney Disease: Mechanisms and Mediators | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2025 | $594,574 | November 1, 2024 | November 30, 2028 | BANEK, CHRISTOPHER T | reporter.nih.gov |
| CDKN1A (p21) regulation of cyst growth | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2025 | $587,212 | January 1, 2025 | November 30, 2028 | YODER, BRADLEY K. | reporter.nih.gov |
| Understanding the physiology and pathophysiology of kidney-derived vasopressin | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2023 to 2025 | $537,861 | April 1, 2023 | March 31, 2028 | ARROYO ORNELAS, JUAN PABLO | reporter.nih.gov |
| Investigating intracellular cholesterol biosynthesis as a regulator of polycystic kidney disease progression | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2025 | $504,621 | January 1, 2025 | November 30, 2029 | LAKHIA, RONAK | reporter.nih.gov |
| High Urinary Phosphate Induces TLR4-mediated Inflammation and Cystogenesis in Polycystic Kidney Disease | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2023 | $469,500 | July 15, 2023 | July 14, 2026 | ZHANG, YAN | reporter.nih.gov |
| Investigation of urinary extracellular vesicles as novel and safe therapeutics for autosomal recessive polycystic kidney disease | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2023 | $465,690 | September 4, 2023 | August 31, 2025 | CHUNG, EUN JI PAIGE | reporter.nih.gov |
| Investigating CD4 T regulatory cells during rapid cystogenesis | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2021 to 2023 | $454,992 | May 1, 2020 | April 30, 2025 | ZIMMERMAN, KURT A | reporter.nih.gov |
| Theory of Solute and Water Transport Across Epithelia | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2021 to 2022 | $423,750 | June 19, 2018 | June 30, 2024 | WEINSTEIN, ALAN M | reporter.nih.gov |
| Noninvasive evaluation of the intrarenal microvasculature in ADPKD | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2021 to 2022 | $418,971 | August 1, 2021 | June 30, 2025 | IRAZABAL, MARIA V | reporter.nih.gov |
| CYTOSKELETAL AND SIGNALING MECHANISMS REGULATING CILIARY TRAFFIC | NIH | National Institute of General Medical Sciences | 2021 | $410,000 | September 1, 2018 | August 31, 2023 | AVASTHI, PRACHEE | reporter.nih.gov |
| Generate Zebrafish Conditional Knockout Model for Ciliopathy Research | NIH | Office of the Director, National Institutes of Health | 2021 to 2022 | $408,375 | July 15, 2021 | May 31, 2025 | PARANT, JOHN M | reporter.nih.gov |
| Metabolic reprogramming and FGF21 signaling in kidney health and polycystic kidney diseases | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2022 | $396,609 | September 15, 2022 | June 30, 2027 | DAI, DAO-FU | reporter.nih.gov |
| Novel signaling pathways in the ciliary inversin compartment | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2021 to 2022 | $393,120 | February 1, 2020 | June 30, 2022 | CZARNECKI, PETER G | reporter.nih.gov |
| The Molecular Mechanisms of Polycystin-1 Proteolytic Cleavage in Kidney Health and Polycystic Kidney Disease | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2021 | $380,777 | September 15, 2017 | May 31, 2024 | QIAN, FENG | reporter.nih.gov |
| Ultrasound-programmable gene editing in kidneys | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2021 to 2022 | $379,212 | September 24, 2021 | August 31, 2024 | MEDINA, SCOTT HAMMOND | reporter.nih.gov |
| NBCe1-mediated Regulation of HCO3- is a Novel Mechanism Underlying Metabolic Reprogramming and Cystogenesis | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2022 to 2025 | $369,035 | March 30, 2022 | March 29, 2027 | BROWN, MATTHEW | reporter.nih.gov |
| High-throughput dissection of transcriptional regulation in kidney disease | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2022 to 2025 | $354,621 | September 1, 2022 | August 31, 2026 | TYCKO, JOSH | reporter.nih.gov |
| Arginine-Polyamine Pathway Inhibitor for Treatment of ADPKD | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2025 | $349,325 | August 1, 2025 | July 31, 2027 | VITEK, MICHAEL PETER | reporter.nih.gov |
| Cellular tools for studying PKD1 regulation in autosomal dominant polycystic kidney disease | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2025 | $342,002 | September 15, 2025 | August 31, 2027 | LARSON, ERIK | reporter.nih.gov |
| Defining the functional role of T-cells in Autosomal Dominant Polycystic Kidney Disease pathology | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2021 to 2022 | $335,804 | August 1, 2018 | July 31, 2024 | HOPP, KATHARINA | reporter.nih.gov |
| Novel signaling pathways in the ciliary inversin compartment | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2023 to 2024 | $328,968 | February 1, 2020 | December 31, 2024 | CZARNECKI, PETER G | reporter.nih.gov |
| CRISPR-Cas Editing as a Genetic Cure for Autosomal Dominant Polycystic Kidney Disease | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2023 | $325,000 | September 19, 2023 | August 31, 2025 | MAXIM, DEMETRIOS S | reporter.nih.gov |
| Design of Calcium-sensing Receptor Targeted Thera(g)nostic Agents | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2024 | $323,743 | September 1, 2024 | August 31, 2025 | YANG, JENNY J. | reporter.nih.gov |
| Polycystin activators as novel therapeutic approach for ADPKD | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2021 to 2022 | $323,000 | July 1, 2021 | June 30, 2023 | DELLING, MARKUS G | reporter.nih.gov |
| The Role of Peroxisome Proliferator Activated Receptor Alpha in Autosomal Dominant Polycystic Kidney Disease | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2021 to 2022 | $319,680 | July 1, 2018 | April 30, 2024 | LAKHIA, RONAK | reporter.nih.gov |
| Targeting Myosin to Treat Polycystic Kidney Disease | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2023 | $298,326 | April 12, 2023 | March 31, 2025 | FU, HONGXIA | reporter.nih.gov |
| The Role of Fibronectin in ADPKD | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2021 | $285,230 | September 20, 2019 | July 31, 2022 | KREIDBERG, JORDAN A | reporter.nih.gov |
| Multi-parametric MRI of ARPKD liver disease | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2021 to 2022 | $252,386 | April 1, 2021 | February 28, 2025 | HARTUNG, ERUM AFTAB | reporter.nih.gov |
| Optimizing Small Molecule Mechanomimetics to Treat Age-related Osteoporosis. | NIH | National Institute on Aging | 2023 | $249,658 | September 30, 2023 | August 31, 2025 | QUARLES, L DARRYL | reporter.nih.gov |
| Therapeutic rescue of Polycystin-1 protein expression by targeting PKD1 upstream open reading frames | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2023 to 2024 | $246,225 | March 1, 2023 | February 28, 2025 | BESSE, WHITNEY ELISE | reporter.nih.gov |
| Measuring metabolically active kidney tissue in autosomal dominant polycystic kidney disease | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2021 | $242,061 | August 1, 2021 | July 31, 2023 | BJORNSTAD, PETTER | reporter.nih.gov |
| High-throughput Flow Culture of 3D Human PKD Models for Therapeutic Screening | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2023 | $234,978 | May 15, 2023 | May 14, 2025 | LIN, NEIL | reporter.nih.gov |
| Complement as a modulator of immunosuppression and progression in Polycystic Kidney Disease | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2021 to 2022 | $233,250 | August 1, 2021 | June 30, 2024 | HOPP, KATHARINA | reporter.nih.gov |
| Comprehensive Analysis of Polycystin Related Endothelial Cell Signaling Pathways | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2021 | $228,166 | September 30, 2012 | March 31, 2024 | WATNICK, TERRY J | reporter.nih.gov |
| Deciphering the role of long noncoding RNA Pvt1 in preclinical models of ADPKD | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2024 to 2025 | $227,288 | December 15, 2023 | November 30, 2025 | ABOUDEHEN, KARAM | reporter.nih.gov |
| Deregulation of Long Noncoding RNA in the Pathogenesis of Autosomal Dominant Polycystic Kidney Disease | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2021 to 2022 | $217,054 | May 15, 2019 | October 31, 2022 | ABOUDEHEN, KARAM | reporter.nih.gov |
| The critical ciliary role of ARL13B in kidney cystogenesis | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2021 to 2023 | $216,849 | September 30, 2020 | August 31, 2024 | VAN SCIVER, ROBERT E | reporter.nih.gov |
| Development of a fluidic chip model of PKD to elucidate cystogenic signals using kidney organoids | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2022 | $215,628 | September 15, 2022 | September 14, 2024 | MORIZANE, RYUJI | reporter.nih.gov |
| Developing a new platform to characterize and treat disease-associated polycystin variants | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2023 | $198,750 | September 1, 2023 | August 31, 2025 | GUERRIERO, CHRISTOPHER JAMES | reporter.nih.gov |
| Metabolic imaging of hyperpolarized 13C pyruvate in polycystic kidney disease | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2022 to 2023 | $193,617 | September 1, 2022 | June 30, 2025 | MAYER, DIRK | reporter.nih.gov |
| Anandamide in blood pressure control | NIH | National Heart, Lung, and Blood Institute | 2024 to 2025 | $189,000 | May 1, 2024 | April 30, 2027 | KLAWITTER, JELENA | reporter.nih.gov |
| Deciphering polycystin-dependent electric signaling of primary cilia in the renal system | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2022 to 2023 | $181,500 | September 2, 2022 | August 31, 2025 | HA, KOTDAJI | reporter.nih.gov |
| Regulation of GLIS3, a Ciliary Transcription Factor that Prevents Kidney Cysts | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2025 | $176,244 | June 15, 2025 | March 31, 2030 | LOEB, GABRIEL B | reporter.nih.gov |
| Impact of mitochondrial dynamics on the development of renal cysts in Tuberous Sclerosis Complex (TSC) | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2021 | $155,959 | September 15, 2018 | July 18, 2022 | LAM, HILAIRE COLLETTA | reporter.nih.gov |
| Develop enabling biochemical and structural tools for dissecting the roles of PKD2L2 in metabolism | NIH | National Center for Advancing Translational Sciences | 2022 | $153,500 | June 1, 2022 | May 31, 2023 | CAO, ERHU | reporter.nih.gov |
| Unraveling the Ciliary Driver of Polycystic Kidney Disease | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2024 | $142,902 | September 1, 2024 | July 31, 2029 | VAN SCIVER, ROBERT E | reporter.nih.gov |
| Unraveling the Ciliary Driver of Polycystic Kidney Disease | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2025 | $141,402 | September 1, 2024 | August 31, 2029 | VAN SCIVER, ROBERT E | reporter.nih.gov |
| Genetic dissection of fluid flow signaling in Left-Right patterning of zebrafish | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2022 to 2024 | $140,191 | July 1, 2022 | June 30, 2025 | FISHER, KATHERINE H | reporter.nih.gov |
| Immune Cell and Epithelial Cell Interactions in Autosomal Dominant Polycystic Kidney Disease | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2023 to 2025 | $137,809 | September 1, 2023 | May 15, 2026 | RAI, VICTORIA | reporter.nih.gov |
| Constructing Mouse and Human Single-cell Atlas in Autosomal Dominant Polycystic Kidney Disease | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2024 | $135,582 | September 1, 2024 | August 31, 2025 | ZIMMERMAN, KURT A | reporter.nih.gov |
| Super-Resolution Deep Learning Framework for Enhanced ADPKD Monitoring via Multi-Sequence Longitudinal MRI | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2025 | $124,284 | August 1, 2025 | November 12, 2025 | CHOOKHACHIZADEH MOGHADAM, MINA | reporter.nih.gov |
| Artificial Intelligence-Based Approaches for Renal Structure Characterization in Computed Tomography Images | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2021 | $119,250 | August 1, 2020 | October 31, 2022 | KLINE, TIMOTHY LEE | reporter.nih.gov |
| Proteostatic regulation of disease-causing polycystin 2 variants | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2021 | $117,375 | April 1, 2020 | March 31, 2022 | GUERRIERO, CHRISTOPHER JAMES | reporter.nih.gov |
| Elucidating the mechanisms of Glis3-regulated development in the pancreas and kidney | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2025 | $116,376 | September 15, 2025 | May 31, 2029 | ZERUTH, GARY T | reporter.nih.gov |
| Advanced MR Imaging and Image Analytics as a Precision Medicine Tool to Manage ADPKD | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2021 | $112,277 | September 15, 2017 | March 14, 2023 | KLINE, TIMOTHY LEE | reporter.nih.gov |
| Metabolome and Microbiome Profiling in Response to Dietary Interventions in Patients with ADPKD | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2022 to 2023 | $110,924 | July 1, 2022 | December 31, 2023 | STEELE, CORTNEY NICOLE | reporter.nih.gov |
| Deregulation of Long Noncoding RNA in the Pathogenesis of Autosomal Dominant Polycystic Kidney Disease | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2023 | $108,526 | May 15, 2019 | March 31, 2025 | ABOUDEHEN, KARAM | reporter.nih.gov |
| WNT signaling in Autosomal Dominant Polycystic Kidney Disease | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2022 to 2024 | $107,610 | February 1, 2022 | January 31, 2025 | HARDY, EMILY P | reporter.nih.gov |
| Cyst induction and growth in ADPKD | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2021 | $100,000 | September 15, 2021 | September 14, 2023 | CEBRIAN LIGERO, CRISTINA | reporter.nih.gov |
| MRI Risk Classification in Children and Young Adults with ADPKD | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2022 | $100,000 | September 15, 2022 | September 14, 2024 | CHAPMAN, ARLENE B | reporter.nih.gov |
| Mechanisms of Impaired Renal Hemodynamics after Spinal Cord Injury | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2022 | $100,000 | September 21, 2022 | September 20, 2023 | OSEI-OWUSU, PATRICK | reporter.nih.gov |
| Discovering ADPKD Modifier Genes and Therapies via Zebrafish Genetics | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2023 | $100,000 | September 20, 2023 | September 19, 2025 | XU, XIAOLEI | reporter.nih.gov |
| Circadian Clock Disruption in the Pathogenesis and Therapy of Polycystic Kidney Disease | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2021 | $99,998 | September 15, 2021 | March 14, 2023 | RAO, REENA | reporter.nih.gov |
| Cellular Mechanisms of Renal Cystic Disease | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2022 | $99,977 | September 21, 2022 | June 30, 2023 | LIEM, KAREL F | reporter.nih.gov |
| Utilization of Fasting Mimicking Diets to Treat and Prevent Clear Cell Renal Cell Carcinoma | NIH | National Cancer Institute | 2022 to 2023 | $95,946 | August 1, 2022 | February 29, 2024 | MURPHY, SEAN | reporter.nih.gov |
| Mechanisms of cyst progression driven by Na,K-ATPase in autosomal dominant polycystic kidney disease (ADPKD). | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2024 to 2025 | $77,593 | August 4, 2024 | August 3, 2028 | TRANT, JORDAN | reporter.nih.gov |
| Polycystin glycosylation regulation and dysregulation in ADPKD | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2024 | $76,756 | May 1, 2024 | April 30, 2025 | ESARTE PALOMERO, ORHI | reporter.nih.gov |
| Targeting kidney resident macrophage niche filling to slow cystic kidney disease | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2024 to 2025 | $64,886 | May 1, 2024 | December 18, 2025 | YASHCHENKO, ALEX | reporter.nih.gov |
| Molecular Basis of Renal Epithelial Cell-Cell Adhesion | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2021 to 2022 | $62,484 | April 1, 2020 | August 31, 2022 | VACHHARAJANI, VIPUL | reporter.nih.gov |
| Pharmacological inhibition of the cystic fibrosis transmembrane conductance regulator (CFTR) | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2025 | $54,538 | July 9, 2025 | July 8, 2029 | YOUNG, PAUL | reporter.nih.gov |
| How membrane lipids mediate ciliary signaling | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2025 | $47,781 | September 1, 2025 | August 31, 2028 | DERDERIAN, CAMILLE | reporter.nih.gov |
| High-throughput dissection of transcriptional regulation in kidney disease | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2021 | $38,721 | September 1, 2020 | August 31, 2022 | TYCKO, JOSH | reporter.nih.gov |
| Roles for Pkd1l1 in bile duct development | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2023 | $38,633 | September 1, 2023 | May 31, 2024 | HELLEN, DOMINICK | reporter.nih.gov |
| Myosin Activation as a Novel Therapeutic Strategy for Polycystic Kidney Disease | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2021 | $29,564 | September 1, 2021 | March 27, 2022 | HELMS, LOUISA M | reporter.nih.gov |
Organizations
Funding by fiscal year
| Fiscal year | NIH awards | NIH amount | NSF awards | NSF amount |
|---|---|---|---|---|
| 2025 | 64 | $30,780,565 | 0 | $0 |
| 2024 | 77 | $32,503,690 | 0 | $0 |
| 2023 | 84 | $33,569,278 | 0 | $0 |
| 2022 | 92 | $34,347,541 | 0 | $0 |
| 2021 | 83 | $33,481,819 | 0 | $0 |
Open federal funding opportunities
From Grants.gov: notices that funded awards in this table, and open notices on the same agency and assistance listing.
Updated November 3, 2026. Read from NIH RePORTER ExPORTER and NSF Award Search. Published by NIH and NSF as U.S. government data. NIH awards are fiscal years 2021 to 2025 (NIH files published to 2026-07-09); NSF awards are fiscal years 2022 to 2026 (NSF files published to 2026-11-02). NIH amounts are the total cost of each fiscal year in the window; NSF amounts are the funds obligated in the window. Organizations are matched on the UEI. Open opportunities come from Grants.gov and match on agency and assistance listing number, and on the notice number NIH prints on an award. Free to reuse with credit to SpecStream under CC BY 4.0. Spot a wrong value? Write to [email protected] with the link to this page.