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Data / Research funding / Fragile X Syndrome

Fragile X Syndrome: 150 NIH awards ($184.4M) to 68 organizations

150 NIH awards ($184.4M) in the NIH spending category Fragile X Syndrome, to 68 organizations, read 2026-11-03. NIH fiscal years 2021 to 2025.

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Awards

150 awards in the window.

AwardAgencyInstitute or divisionFiscal yearAmount in windowStartEndPrincipal investigatorSource
South Carolina IDeA Networks of Biomedical Research Excellence (SC INBRE)NIHNational Institute of General Medical Sciences2021 to 2025$19,943,827September 30, 2001August 31, 2026GOLDSMITH, EDIE Creporter.nih.gov
FMRP-mediated Regulation in Human Brain Development and Therapeutic AdvancementNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2021 to 2024$6,546,370September 25, 2020June 30, 2025JIN, PENGreporter.nih.gov
Translational medicine and mechanistic studies of brain neurophysiology in Fragile X SyndromeNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2021 to 2024$6,538,717September 25, 2020June 30, 2025ERICKSON, CRAIGreporter.nih.gov
Translational Control in Memory and Brain DisordersNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$5,426,946May 1, 2021April 30, 2029KLANN, ERICreporter.nih.gov
New mechanisms and technologies for understanding post-transcriptional gene regulation in neuronsNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$5,391,456June 1, 2019May 31, 2027JAFFREY, SAMIE Rreporter.nih.gov
Mechanisms of Synaptic Transmission in Healthy and Disease StatesNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$4,140,156May 1, 2019April 30, 2027KLYACHKO, VITALY Areporter.nih.gov
A Family Genetic Study of Autism and Fragile X SyndromeNIHNational Institute of Mental Health2021 to 2025$3,842,448May 1, 2012April 30, 2026LOSH, MOLLY Creporter.nih.gov
Gene editing in the brain with CRISPR-PEGNIHNational Institute of Mental Health2021 to 2025$3,288,527April 1, 2021January 31, 2027LEE, HYE YOUNGreporter.nih.gov
Investigating mechanisms underlying impaired social and spatial cognition in rodent models of Fragile X syndromeNIHNational Institute of Mental Health2022 to 2025$3,047,204August 1, 2022May 31, 2027COLGIN, LAURA Lreporter.nih.gov
BRITE-Eye: An integrated discovery engine for CNS therapeutic targets driven by high throughput genetic screens, functional readouts in human neurons, and machine learningNIHNational Institute of Mental Health2023 to 2024$2,999,997September 19, 2023August 31, 2025WILLIAMS, LUIS ALBERTOreporter.nih.gov
Association of the Fragile X Premutation with Cognitive and Behavioral Skills in ChildrenNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2021 to 2025$2,944,001September 1, 2021August 31, 2027HINTON, VERONICA Jreporter.nih.gov
Aging Symptom Trajectories in Mother Carriers of the FMR1 PremutationNIHNational Institute on Aging2022 to 2025$2,847,621July 15, 2022March 31, 2027KLUSEK, JESSICAreporter.nih.gov
Autonomic and Sensory Dysfunctions in FMR1 Conditions: Development, Mechanisms and ConsequencesNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2022 to 2025$2,731,934July 8, 2022April 30, 2027ROBERTS, JANE Ereporter.nih.gov
The relationship between language and executive function in DLD and FXS over timeNIHNational Institute on Deafness and Other Communication Disorders2021 to 2025$2,672,873August 15, 2021May 31, 2027STERLING, AUDRA MARIEreporter.nih.gov
Genotype-Phenotype Relationships in Fragile X FamiliesNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2021 to 2025$2,496,604June 15, 1998May 31, 2028HAGERMAN, RANDI J.reporter.nih.gov
Postnatal Oxytocin Treatment and Cognitive Function in Fragile XNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2021 to 2025$2,479,522April 5, 2021September 30, 2026GALL, CHRISTINE Mreporter.nih.gov
Cerebellum and cerebellar-regulated circuit contribution to Fragile X SyndromeNIHNational Institute of Mental Health2021 to 2024$2,436,836July 1, 2020April 30, 2025TSAI, PETER T.reporter.nih.gov
Trajectories and Markers of Neurodegeneration in Carriers of the Fragile X PremutationNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$2,395,710June 1, 2007December 31, 2029HESSL, DAVID Rreporter.nih.gov
A molecular investigation of retinoic acid-dependent homeostatic synaptic plasticityNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$2,319,440May 1, 2020April 30, 2025CHEN, LUreporter.nih.gov
Language and Executive Function in Females with ASD or FXSNIHNational Institute on Deafness and Other Communication Disorders2023 to 2025$2,299,215September 1, 2023June 30, 2028STERLING, AUDRA MARIEreporter.nih.gov
Nonsense-mediated mRNA decay and beyondNIHNational Institute of General Medical Sciences2023 to 2025$2,298,136August 1, 2023July 31, 2028MAQUAT, LYNNE Ereporter.nih.gov
Mechanism of Gp1 mGluR-dependent translation and plasticityNIHNational Institute of Mental Health2021 to 2025$2,269,230December 1, 2020October 31, 2026TSAI, NIEN-PEIreporter.nih.gov
Novel therapy for Fragile X syndromeNIHNational Institute of Mental Health2021 to 2022$2,206,174September 15, 2017March 31, 2025TUCCI, FABIO COHENreporter.nih.gov
Emergence, stability, and predictors of anxiety in Fragile X syndromeNIHNational Institute of Mental Health2023 to 2025$2,150,560September 1, 2016May 31, 2028HOGAN, ABIGAIL LEEreporter.nih.gov
FX ENTRAIN: Perturbation of neurodynamics underlying sensory hyperarousal and statistical learning in Youth with FXSNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2023 to 2025$2,143,187August 7, 2023July 31, 2028PEDAPATI, ERNEST VIJAYreporter.nih.gov
Mechanisms of olfactory signal processingNIHNational Institute on Deafness and Other Communication Disorders2021 to 2025$2,072,411April 1, 2005March 31, 2027SCHOPPA, NATHAN ERICreporter.nih.gov
Connecting 3D genome misfolding to transcriptional silencing in fragile X syndromeNIHNational Institute of Mental Health2021 to 2024$2,066,257August 15, 2019January 31, 2029PHILLIPS-CREMINS, JENNIFER ELIZABETHreporter.nih.gov
Axonal FMRP in Synaptic DevelopmentNIHNational Institute of Mental Health2021 to 2025$2,040,040September 20, 2021June 30, 2027WANG, YUANreporter.nih.gov
Cortical Interneuron Dysfunction in Fragile X SyndromeNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2022 to 2025$1,989,137April 1, 2022February 28, 2027PORTERA-CAILLIAU, CARLOSreporter.nih.gov
Mechanism of Protein Synthesis and Translational ControlNIHNational Institute of General Medical Sciences2021 to 2025$1,962,066June 1, 2021May 31, 2027JOSEPH, SIMPSONreporter.nih.gov
CGG repeat associated translation in Fragile X-associated Tremor/Ataxia SyndromeNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$1,869,734April 1, 2014December 31, 2025TODD, PETER Kreporter.nih.gov
Characterization of the role of Fmr1 in oxytocin neuronal subtypesNIHNational Institute of Mental Health2021 to 2024$1,866,744February 1, 2020November 30, 2025DOLEN, GULreporter.nih.gov
Deciphering the roles of FXR1 in health and myopathyNIHNational Heart, Lung, and Blood Institute2023 to 2025$1,854,831August 1, 2022July 31, 2026GREGORIO, CAROL Creporter.nih.gov
Circuit Defects Underlying Deficits in Social Touch in Fragile X SyndromeNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2021 to 2025$1,833,033August 1, 2024April 30, 2029PORTERA-CAILLIAU, CARLOSreporter.nih.gov
Circuit Disruptions Underlying Atypical Sensory Processing in Fragile X SyndromeNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$1,820,216July 15, 2020March 31, 2025PORTERA-CAILLIAU, CARLOSreporter.nih.gov
FXS: Late Adolescence and Early AdulthoodNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2022 to 2025$1,801,993April 1, 2016June 30, 2027BRADY, NANCY CAROLINEreporter.nih.gov
FMRP Regulation of Gene ExpressionNIHNational Institute of General Medical Sciences2021 to 2023$1,796,124September 1, 2020August 31, 2025RICHTER, JOEL Dreporter.nih.gov
Mitochondrial control of protein translation in Fragile XNIHNational Institute of Neurological Disorders and Stroke2021 to 2023$1,782,377June 1, 2019March 31, 2025JONAS, ELIZABETH ANNreporter.nih.gov
RNA Control of Neural FunctionNIHNational Institute of General Medical Sciences2023 to 2025$1,773,265May 1, 2023February 29, 2028RICHTER, JOEL Dreporter.nih.gov
Neural Mechanisms of Predictive Impairments in AutismNIHNational Institute of Mental Health2021 to 2025$1,768,787September 20, 2017February 29, 2028CHUBYKIN, ALEXANDERreporter.nih.gov
Adults with Fragile X Syndrome: Health and Life Course TrajectoriesNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2023 to 2025$1,709,403September 1, 2015May 31, 2028DAWALT, LEANN SMITHreporter.nih.gov
Dopamine regulation of infant perceptual motor development and communicationNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2023 to 2025$1,695,044September 1, 2023June 30, 2028O'CONNELL, LAUREN Areporter.nih.gov
Mitochondrial dysfunction in Fragile X: Mechanisms and treatmentsNIHNational Institute of Neurological Disorders and Stroke2023 to 2025$1,572,277June 1, 2023May 31, 2028JONGENS, THOMAS Areporter.nih.gov
Postnatal transient connectivity in brain development and implications in fragile x syndromeNIHNational Institute of Mental Health2024 to 2025$1,476,039July 1, 2024January 31, 2029POUCHELON, GABRIELLEreporter.nih.gov
Myelination Deficits Underlying Auditory Issues in Fragile X SyndromeNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2021 to 2025$1,449,156September 9, 2021July 31, 2028MCCULLAGH, ELIZABETH ANNEreporter.nih.gov
Defining post-transcriptional gene regulation in FMRP-deficiency usingmiRNA:target chimerasNIHNational Institute of Mental Health2023 to 2025$1,447,055January 1, 2023November 30, 2027MEFFERT, MOLLIE KATHERINEreporter.nih.gov
Interrogate FMRP functions in primate brain developmentNIHNational Institute of Mental Health2024 to 2025$1,435,409May 1, 2024February 28, 2029ZHAO, XINYUreporter.nih.gov
Astroglia-Mediated Pathogenic Mechanisms in Fragile X Syndrome (FXS)NIHNational Institute of Mental Health2023 to 2025$1,432,014May 15, 2016April 30, 2026YANG, YONGJIEreporter.nih.gov
A lipid-induced RNA-binding protein in atherosclerosisNIHNational Heart, Lung, and Blood Institute2021 to 2023$1,401,825April 1, 2020March 31, 2025DIMAYUGA, PAUL C.reporter.nih.gov
The Role of Astrocytes in the Fragile X PathogenesisNIHNational Institute of Neurological Disorders and Stroke2021 to 2023$1,371,795January 1, 2019December 31, 2024DUNAEVSKY, ANNAreporter.nih.gov
Nonconventional role of ADCY in Gq-mediated neuronal signaling and neuroplasticityNIHNational Institute of Mental Health2021 to 2023$1,343,860April 1, 2019January 31, 2025WANG, HONGBINGreporter.nih.gov
Identifying Convergent Circuit Disruptions Across Genetically-Distinct Models of AutismNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2023 to 2025$1,251,466September 22, 2023May 31, 2028AUERBACH, BENJAMIN Dreporter.nih.gov
Therapeutic Potential of Rescued FMR1 Mis-Splicing in Fragile X SyndromeNIHNational Institute of Neurological Disorders and Stroke2023 to 2025$1,243,688June 1, 2023May 31, 2028RICHTER, JOEL Dreporter.nih.gov
Fragile X-associated tremor/ataxia syndrome (FXTAS) pathology and anatomy: imaging and clinical correlatesNIHNational Institute of Neurological Disorders and Stroke2021 to 2022$1,212,893September 1, 2018May 31, 2024MARTINEZ-CERDENO, VERONICAreporter.nih.gov
Language Development in Fragile X SyndromeNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2021 to 2022$1,199,669September 1, 1987May 31, 2024ABBEDUTO, LEONARD J.reporter.nih.gov
FMRP regulation of mitochondria and metabolism in mammalian brain developmentNIHNational Institute of Neurological Disorders and Stroke2024 to 2025$1,199,340September 1, 2024May 31, 2029ZHAO, XINYUreporter.nih.gov
Mechanisms and biomarkers of disease progression in Fragile X-associated tremor/ataxia syndrome (FXTAS)NIHNational Institute of Neurological Disorders and Stroke2024 to 2025$1,198,205January 26, 2024November 30, 2028MOSCONI, MATTHEW Wreporter.nih.gov
Molecular Basis of rCGG-Mediated NeurodegenerationNIHNational Institute of Neurological Disorders and Stroke2021 to 2023$1,180,305January 1, 2006January 31, 2025NELSON, DAVID LORENreporter.nih.gov
Physiological mechanisms underlying disrupted hippocampal function in Fragile X syndromeNIHNational Institute of Mental Health2021 to 2022$1,173,890November 16, 2020October 31, 2023COLGIN, LAURA Lreporter.nih.gov
Clinical Outcome Assessment and Treatment Monitoring Markers for Clinical Trial Readiness in FXTASNIHNational Institute of Neurological Disorders and Stroke2025$1,169,064July 15, 2025June 30, 2030HESSL, DAVID Rreporter.nih.gov
FXTAS Key Molecular Pathways Converge with Other Neurodegenerative DisordersNIHNational Institute of Neurological Disorders and Stroke2022 to 2025$1,104,854April 15, 2022March 31, 2027LOZANO, REYMUNDOreporter.nih.gov
Crosstalk between DNA repair pathways in repeat instabilityNIHNational Institute of General Medical Sciences2023 to 2025$1,075,966February 1, 2023December 31, 2026PLUCIENNIK, ANNAreporter.nih.gov
Developmental trajectory of anxiety, avoidance, and arousal in girls with the FMR1 full mutationNIHNational Institute of Mental Health2021 to 2022$918,068May 1, 2022August 31, 2023REISS, ALLAN Lreporter.nih.gov
The Role of MDM2 in FMRP regulation of neuronal developmentNIHNational Institute of Mental Health2021 to 2022$917,272July 9, 2018April 30, 2024ZHAO, XINYUreporter.nih.gov
Nonsense-Mediated mRNA Decay and Nonsense-Mediated mRNA Decay FactorsNIHNational Institute of General Medical Sciences2021 to 2022$884,498August 1, 1999July 31, 2023MAQUAT, LYNNE Ereporter.nih.gov
Glial roles in experience-dependent critical period remodelingNIHNational Institute of Neurological Disorders and Stroke2024 to 2025$815,738April 1, 2024March 31, 2029BROADIE, KENDALreporter.nih.gov
Lymphatic dysfunction in neurodevelopmental disorders and associated behaviorsNIHNational Institute of Mental Health2023 to 2024$805,000September 1, 2023December 15, 2024LOUVEAU, ANTOINEreporter.nih.gov
Neural Markers of Language Development in Fragile X Syndrome and Autism Spectrum DisorderNIHNational Institute on Deafness and Other Communication Disorders2021 to 2024$687,216April 1, 2020March 31, 2025WILKINSON, CAROL LEEreporter.nih.gov
Mechanisms of sound hypersensitivity in a rat model of autismNIHNational Institute on Deafness and Other Communication Disorders2021 to 2024$649,145April 10, 2020March 31, 2026AUERBACH, BENJAMIN Dreporter.nih.gov
Tracking early emergence of sound perception impairments in FXS with multimodal fNIRS/EEGNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2022 to 2025$608,612September 1, 2022August 31, 2027SMITH, ELIZABETH GAYLEreporter.nih.gov
Deciphering the roles of FXR1 in health and myopathyNIHNational Heart, Lung, and Blood Institute2022$601,489August 1, 2022April 30, 2023GREGORIO, CAROL Creporter.nih.gov
Connecting 3D genome misfolding to transcriptional silencing in fragile X syndromeNIHNational Institute of Mental Health2025$555,605August 15, 2019January 31, 2029PHILLIPS-CREMINS, JENNIFER ELIZABETHreporter.nih.gov
Genetic and Developmental Analyses of Fragile X Mental Retardation ProteinNIHNational Institute of Mental Health2023$516,155August 15, 2009November 30, 2024BROADIE, KENDALreporter.nih.gov
Contribution of Glia to Sleep/Wake Disturbances in FXSNIHNational Institute of Neurological Disorders and Stroke2025$515,898April 1, 2025February 28, 2030DUNAEVSKY, ANNAreporter.nih.gov
Biochemical characterization of a novel Fragile X Mental Retardation Protein nuclease functionNIHNational Institute of General Medical Sciences2021 to 2023$514,000July 1, 2005August 31, 2025MIHAILESCU, MIHAELA Rreporter.nih.gov
Unraveling the Impact of Extracellular Vesicle-Loaded FXR1 mRNA on Re-educating Cancer MicroenvironmentNIHNational Cancer Institute2025$494,160September 11, 2025August 31, 2030CHALUVALLY-RAGHAVAN, PRADEEPreporter.nih.gov
Attenuation of atherosclerosis by regulation of VSMC inflammatory gene mRNA stabilityNIHNational Heart, Lung, and Blood Institute2021$491,772February 1, 2018January 31, 2024AUTIERI, MICHAEL Vreporter.nih.gov
Role of Fragile X Mental Retardation Protein on Gene Expression in Auditory Brainstem DevelopmentNIHNational Institute on Deafness and Other Communication Disorders2023 to 2025$489,542April 1, 2021March 31, 2026SAKANO, HITOMIreporter.nih.gov
Human cerebral organoids as a model system for neural development and diseaseNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2021 to 2022$488,040August 1, 2020July 31, 2024WATANABE, MOMOKOreporter.nih.gov
Electrophysiological Biomarkers of Neurocognitive Deficits in Fragile X SyndromeNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2021 to 2024$482,280April 1, 2020December 2, 2024SCHMITT, LAURENreporter.nih.gov
Genetic and Developmental Analyses of Fragile X Mental Retardation ProteinNIHNational Institute of Mental Health2021$476,491August 15, 2009November 30, 2022BROADIE, KENDALreporter.nih.gov
Neurodegenerative mechanisms of motor, executive, and memory decline in females with Fragile X-associated tremor/ataxia syndrome (FXTAS)NIHNational Institute on Aging2023 to 2024$465,831February 15, 2023January 31, 2025MOSCONI, MATTHEW Wreporter.nih.gov
Elucidating Fragile X Syndrome by Investigating FMRP Molecular FunctionNIHNational Institute of Mental Health2023$460,625July 7, 2023July 6, 2025RICHTER, JOEL Dreporter.nih.gov
A new diagnostic tool for rapid detection and characterization of REPEAT SEQUENCES in inherited diseasesNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2022 to 2023$459,016August 15, 2022December 31, 2024REED, JASON Creporter.nih.gov
Understanding the Genome Maintenance Function of the Fragile X Protein (FMRP)NIHNational Institute of Mental Health2022 to 2023$448,250July 15, 2022June 30, 2025FENG, WENYIreporter.nih.gov
Molecular mechanisms of glial-mediated synapse alterations in Fragile X syndromeNIHNational Institute of Neurological Disorders and Stroke2021$445,500April 1, 2021September 30, 2023MASON, CAROL A.reporter.nih.gov
Localized translational dysregulation in an autism spectrum disorder model using in situ cryo-EMNIHNational Institute of Neurological Disorders and Stroke2024$443,121July 1, 2024June 30, 2026LOERCH, SARAHreporter.nih.gov
Multilevel Analysis of Cortical Interneuron Dysfunction in Fragile X SyndromeNIHNational Institute of Mental Health2023 to 2024$442,160December 1, 2022November 30, 2025AU, EDMUNDreporter.nih.gov
Defining Plasticity and Homeostasis in Fragile X SyndromeNIHNational Institute of Mental Health2021$439,297July 1, 2021June 30, 2023HUNTSMAN, MOLLY-MAUREENreporter.nih.gov
Determining whether metabolic and mitochondrial pathophysiology are a common feature of three distinct genetic models of ASDNIHNational Institute of Mental Health2022 to 2023$439,263December 3, 2021November 30, 2024JONGENS, THOMAS Areporter.nih.gov
Contributors to FXTAS ProgressionNIHNational Institute of Neurological Disorders and Stroke2022$439,250July 1, 2022June 30, 2025GIULIVI, CECILIAreporter.nih.gov
Transcriptional Mechanism underlying Neuronal Hyperexcitability in FXSNIHNational Institute of Neurological Disorders and Stroke2023$436,150June 1, 2023May 31, 2026TSAI, NIEN-PEIreporter.nih.gov
Fmr1 Function and Repeat Expansion in the Developing GermlineNIHNational Institute of General Medical Sciences2021$435,875December 26, 2017November 30, 2022LAIRD, DIANA Jreporter.nih.gov
Developing an Astroglial Model for Fragile X SyndromeNIHNational Institute of Neurological Disorders and Stroke2021$434,385August 1, 2021January 31, 2025DUNAEVSKY, ANNAreporter.nih.gov
A Novel Role of Fragile-X Mental Retardation Protein in Mitochondrial Calcium HomeostasisNIHNational Institute of Mental Health2022 to 2023$432,850May 1, 2022April 30, 2024LU, BINGWEIreporter.nih.gov
Interrogating neurogenic defects in complex assembloid models of fragile X syndromeNIHNational Institute of Mental Health2023$430,375August 15, 2023August 14, 2025RAJ, NISHAreporter.nih.gov
Single-Molecule Imaging of Ubiquitination Dynamics in NeuronsNIHNational Institute of Neurological Disorders and Stroke2023$430,375September 15, 2023August 31, 2025BASSELL, GARY Jreporter.nih.gov
Membrane trafficking impairments in fragile x syndromeNIHNational Institute of Neurological Disorders and Stroke2025$430,375July 1, 2025June 30, 2027BASSELL, GARY Jreporter.nih.gov
Discovery of small molecule activators of the Slack potassium channel for use as cell-based probes for the study of fragile X syndromeNIHNational Institute of Mental Health2021 to 2022$428,348December 1, 2020October 31, 2023EMMITTE, KYLE Areporter.nih.gov
Unraveling the role of satellite glial cells in sensory hypersensitivity in Fragile X syndromeNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2023$427,625September 6, 2023August 31, 2025CAVALLI, VALERIAreporter.nih.gov
Unraveling satellite glial cells dysfunctions in spiral ganglia of a mouse model of Fragile X syndromeNIHNational Institute on Deafness and Other Communication Disorders2024 to 2025$427,625March 1, 2024February 28, 2026CAVALLI, VALERIAreporter.nih.gov
Pathophysiology and treatment of fragile X and related disordersNIHNational Institute of Neurological Disorders and Stroke2022 to 2023$426,523March 1, 2022February 29, 2024BEAR, MARK Freporter.nih.gov
Role of Fragile X Mental Retardation Protein on Gene Expression in Auditory Brainstem DevelopmentNIHNational Institute on Deafness and Other Communication Disorders2021 to 2023$425,749April 1, 2021July 31, 2023SAKANO, HITOMIreporter.nih.gov
Mechanisms of FMR1 gene-mediated reproductive disordersNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2025$425,628August 1, 2025July 31, 2027COSS, DJURDJICAreporter.nih.gov
Establishing Drosophila melanogaster as a model for developmental neurotoxicity assessment of air pollutants using diesel exhaustNIHNational Institute of Environmental Health Sciences2024$421,705June 13, 2024May 31, 2027MILLER-SCHULZE, JUSTIN P.reporter.nih.gov
Reactivation of Epigenetically Silenced FMR1 as a Therapeutic Approach for Fragile X SyndromeNIHNational Institute of Mental Health2021$418,750July 1, 2017June 30, 2022GREEN, MICHAEL Rreporter.nih.gov
Dysregulation of mTORC2 and cofilin signaling in Fragile X SyndromeNIHNational Institute of Mental Health2021$417,500January 1, 2011April 30, 2023ZUKIN, R. SUZANNEreporter.nih.gov
Language as a Candidate Marker of FXTAS in FMR1 Premutation CarriersNIHNational Institute on Deafness and Other Communication Disorders2023 to 2024$373,437September 16, 2022July 31, 2025MALTMAN, ALEXIS NELLreporter.nih.gov
Neural coordination and discoordination in Fmr1 null miceNIHNational Institute of Neurological Disorders and Stroke2021$343,384August 15, 2017April 30, 2022FENTON, ANDRE ANTONIOreporter.nih.gov
Impact of Child and Maternal Gestures on Word Learning in Fragile X SyndromeNIHNational Institute on Deafness and Other Communication Disorders2021 to 2022$303,114August 1, 2020July 31, 2025MATTIE, LAURA Jreporter.nih.gov
The Histone Code of Neuronal Function and DysfunctionNIHNational Institute of Mental Health2021$247,106January 1, 2019November 30, 2021KORB, ERICA MEGANreporter.nih.gov
Lymphatic dysfunction in neurodevelopmental disorders and associated behaviorsNIHNational Institute of Mental Health2025$241,500December 16, 2024November 30, 2029LOUVEAU, ANTOINEreporter.nih.gov
Mechanisms of microRNA dysregulation in Fragile X SyndromeNIHNational Institute of Mental Health2023 to 2025$226,480September 13, 2023September 12, 2026KOSTI, ADAMreporter.nih.gov
Sensory Hypersensitivity in Fragile X Syndrome Due to Deficits in Tonic Inhibition Reversed by Neuroactive SteroidsNIHNational Institute of Neurological Disorders and Stroke2021$204,300April 1, 2020March 31, 2022DAVIES, PAUL ANDREWreporter.nih.gov
Mechanisms of Loudness Intolerance in a Rat Model of Fragile XNIHNational Institute on Deafness and Other Communication Disorders2021$199,375April 1, 2020March 31, 2022SALVI, RICHARD Jreporter.nih.gov
Metabolic Dysregulation in FXTAS PathogenesisNIHNational Institute on Aging2021$197,700August 1, 2020April 30, 2023ALLEN, EMILY GRAVESreporter.nih.gov
Language as a Candidate Marker of FXTAS in FMR1 Premutation CarriersNIHNational Institute on Deafness and Other Communication Disorders2022 to 2023$196,875September 16, 2022August 31, 2023MALTMAN, ALEXIS NELLreporter.nih.gov
Reelin and Fragile X SyndromeNIHNational Institute of Neurological Disorders and Stroke2025$187,500January 3, 2025December 31, 2026NASH, KEVIN RONreporter.nih.gov
Anomalous Sensorimotor Physiology in Fragile X SyndromeNIHNational Institute of Mental Health2021$179,583April 7, 2017March 31, 2022PEDAPATI, ERNEST VIJAYreporter.nih.gov
The Role of Astrocyte BMP Signaling in Fragile X SyndromeNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2021 to 2024$174,515September 1, 2021August 31, 2025DENG, JAMES DERONGreporter.nih.gov
Mechanistic underpinnings of pragmatics in ASD: Insights from FMR1-mutation conditionsNIHNational Institute on Deafness and Other Communication Disorders2024$160,000September 24, 2024August 31, 2026LOSH, MOLLY Creporter.nih.gov
Fragile X messenger ribonucleoprotein-1 mediated regulation of the Clathrin-Associated Adaptor Complex Protein-2 (AP2)NIHNational Institute of Mental Health2024$156,500January 1, 2024December 31, 2025BASSELL, GARY Jreporter.nih.gov
Defining the Language Phenotype of the FMR1 PremutationNIHNational Institute on Deafness and Other Communication Disorders2021$146,500April 1, 2019March 31, 2024KLUSEK, JESSICAreporter.nih.gov
Vocabulary Acquisition in a Meaningful Context: Differentiating Learning Profiles for Autism Spectrum Disorder and Fragile X SyndromeNIHNational Institute on Deafness and Other Communication Disorders2021$145,674September 1, 2019August 31, 2024KOVER, SARA TERESAreporter.nih.gov
Elucidating the RNA-mediated mechanisms governing H3K9me3 deposition in fragile X syndromeNIHNational Institute of Neurological Disorders and Stroke2022 to 2024$143,420September 1, 2022December 29, 2025MALACHOWSKI, THOMAS ERNSTreporter.nih.gov
Understanding the role of the frontal cortex during cognitive flexibility in Fmr1 knock outsNIHNational Institute of Mental Health2023 to 2024$143,408March 1, 2023February 28, 2026PLAKKE ANDERSON, BETHANYreporter.nih.gov
Establishing Drosophila melanogaster as a model for determining gene-environment interactions that confer risk of autism using bisphenols and the autism risk gene, fragile x mental retardation 1NIHNational Institute of General Medical Sciences2021$142,000June 10, 2019May 31, 2024MULLIGAN, KIMBERLY ANNEreporter.nih.gov
ISRIB as a promising therapeutic for Fragile X syndromeNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2021 to 2022$140,296July 17, 2020July 16, 2023COULSON, ROCHELLE LYNNreporter.nih.gov
Examining the role of specific NMDA receptor subunits in cortical circuit dysfunction in Fragile X SyndromeNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2023 to 2025$118,420September 1, 2023August 31, 2026SHEDD, ALEYA MICHELLEreporter.nih.gov
Astrocyte-neuron interactions in Rett Syndrome and Fragile X SyndromeNIHNational Institute of Neurological Disorders and Stroke2025$118,395August 7, 2025February 28, 2027LYON, KRISTINE ANNEreporter.nih.gov
Elucidating the spatially coordinated mechanisms of transcriptional silencing in fragile X syndromeNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2024 to 2025$108,512March 1, 2024February 28, 2028PHAM, KENNETHreporter.nih.gov
Characterizing the regulatory roles of microRNA on mitochondria in the mammalian CNSNIHNational Institute of Mental Health2024 to 2025$104,512September 5, 2024March 4, 2027EISS, EMILYreporter.nih.gov
Characterization of Fragile X Syndrome 3D Cortical OrganoidsNIHNational Institute of Mental Health2024 to 2025$90,739March 8, 2024February 28, 2026SANDOVAL, SORAYA OROZCOreporter.nih.gov
Mechanisms underlying impaired hippocampal physiology in Fragile X SyndromeNIHNational Institute of Mental Health2022 to 2023$87,990June 1, 2022July 31, 2024DONAHUE, MARGARET MCNEILreporter.nih.gov
Maternal-Child RSA Synchrony in Infants with Fragile X SyndromeNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2024 to 2025$85,712February 1, 2024January 31, 2027HANTMAN, RACHELreporter.nih.gov
Mechanisms of Setd2 in cortical circuit function: Convergence with Fragile X SyndromeNIHNational Institute of Neurological Disorders and Stroke2024 to 2025$81,576January 5, 2024November 4, 2026POPE, ALEXANDERreporter.nih.gov
Health Disparities of Patients with Fragile X from Diverse Racial & Ethnic GroupsNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2023$77,750April 6, 2023November 13, 2023MOVAGHAR, AREZOOreporter.nih.gov
Health Disparities of Patients with Fragile X from Diverse Racial & Ethnic GroupsNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2024$75,501April 6, 2023March 31, 2026MOVAGHAR, AREZOOreporter.nih.gov
Characterization of the Attentional Profile in Women and Girls with a Fragile X Premutation AlleleNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2023 to 2025$68,232June 1, 2024February 14, 2027RUSSELL-GILLER, SHIRAreporter.nih.gov
Impact of Cognitive function on Balance and Gait Markers for FXTASNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2021$62,465July 7, 2016June 30, 2022O'KEEFE, JOAN Areporter.nih.gov
Elucidating the interplay between cohesin-mediated loop extrusion and heterochromatin in single cells.NIHNational Human Genome Research Institute2025$48,974January 1, 2025December 31, 2027PATEL, ROHAN DIPAKreporter.nih.gov
CGG repeat associated translation in Fragile X gene function and diseaseNIHNational Institute of Neurological Disorders and Stroke2021 to 2022$46,030May 1, 2020July 31, 2022WRIGHT, SHANNONreporter.nih.gov
The cadence of social communication: Unraveling speech rhythm and underlying neural, motor, and genetic mechanisms.NIHNational Institute on Deafness and Other Communication Disorders2025$44,751December 1, 2025May 31, 2027ETHRIDGE, SARAHreporter.nih.gov
Network mechanisms underlying core behavioral features in Fragile X SyndromeNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2024$42,574August 16, 2024August 15, 2026NORRIS, JORDANreporter.nih.gov
The roles of Fragile-X related protein 1 in cardiomyocyte and heart biologyNIHNational Heart, Lung, and Blood Institute2024$41,627December 1, 2024November 30, 2027BAIS, GABRIELLEreporter.nih.gov
Language, physiology, and anxiety across contexts in autism spectrum disorder and fragile X syndromeNIHNational Institute on Deafness and Other Communication Disorders2021$38,124July 1, 2020June 30, 2022LORANG, EMILY KATHRYNreporter.nih.gov
FXR1 Regulates Blood Pressure by Altering Contraction of Smooth MuscleNIHNational Heart, Lung, and Blood Institute2022$31,586July 1, 2022June 8, 2023ST. PAUL, AMANDAreporter.nih.gov
Trinucleotide repeat disorders and the 3D genomeNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2021$25,721September 1, 2019May 16, 2022ZHOU, LINDAreporter.nih.gov
Cellular and molecular mechanisms of auditory processing deficits in a mouse model of Fragile X SyndromeNIHNational Institute of Neurological Disorders and Stroke2021$18,944April 1, 2020June 25, 2021RAIS, MAHAMreporter.nih.gov
2024 Fragile X and Autism-Related Disorders Gordon Research Conference and Gordon Research SeminarNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2024$15,000April 1, 2024March 31, 2025HUBER, KIMBERLY M.reporter.nih.gov

Organizations

OrganizationPlaceNIH awardsNIH amountNSF awardsNSF amount
University of South Carolina at ColumbiaColumbia, SC6$27.9 million0$0
University of Wisconsin-MadisonMadison, WI10$10.6 million0$0
Cincinnati Childrens Hosp Med CTRCincinnati, OH5$10 million0$0
University of California at DavisDavis, CA6$8.9 million0$0
Emory UniversityAtlanta, GA7$8.4 million0$0
New York UniversityNew York, NY2$5.8 million0$0
Univ of Massachusetts Med SCH WorcesterWorcester, MA5$5.7 million0$0
University of California Los AngelesLos Angeles, CA3$5.6 million0$0
Stanford UniversityStanford, CA5$5.5 million0$0
Weill Medical Coll of Cornell UnivNew York, NY1$5.4 million0$0
University of PennsylvaniaPhiladelphia, PA9$5.2 million0$0
Washington UniversitySaint Louis, MO3$5 million0$0
University of Illinois at Urbana-ChampaignUrbana, IL5$4.9 million0$0
University of Texas at AustinAustin, TX3$4.3 million0$0
Northwestern UniversityChicago, IL2$4 million0$0
University of RochesterRochester, NY3$3.6 million0$0
University of Kansas Center for Research IncLawrence, KS3$3.5 million0$0
Johns Hopkins UniversityBaltimore, MD3$3.4 million0$0
University of Texas HLTH Science CenterSan Antonio, TX1$3.3 million0$0
Ut Southwestern Medical CenterDallas, TX4$3.1 million0$0
Quiver Bioscience Inc.Cambridge, MA1$3 million0$0
University of California-IrvineIrvine, CA2$3 million0$0
Icahn School of Medicine at Mount SinaiNew York, NY2$3 million0$0
CUNY Queens CollegeFlushing, NY1$2.9 million0$0
University of Colorado DenverAurora, CO2$2.5 million0$0
University of Nebraska Medical CenterOmaha, NE3$2.3 million0$0
Epigen Biosciences, Inc.San Diego, CA1$2.2 million0$0
University of California, San DiegoLa Jolla, CA2$2.1 million0$0
Florida State UniversityTallahassee, FL1$2 million0$0
University of Michigan at Ann ArborAnn Arbor, MI2$1.9 million0$0
Vanderbilt UniversityNashville, TN3$1.8 million0$0
Yale UniversityNew Haven, CT1$1.8 million0$0
Purdue UniversityWest Lafayette, IN1$1.8 million0$0
Tufts University BostonBoston, MA2$1.6 million0$0
Cold Spring Harbor LaboratoryCold Spring Harbor, NY1$1.5 million0$0
Oklahoma State UniversityStillwater, OK1$1.4 million0$0
Cedars-Sinai Medical CenterLos Angeles, CA1$1.4 million0$0
Michigan State UniversityEast Lansing, MI1$1.3 million0$0
Baylor College of MedicineHouston, TX1$1.2 million0$0
Thomas Jefferson UniversityPhiladelphia, PA1$1.1 million0$0
Cleveland Clinic Lerner Com-CwruCleveland, OH2$1 million0$0
University of ArizonaTucson, AZ2$974,9260$0
Columbia University Health SciencesNew York, NY2$887,6600$0
Boston Children's HospitalBoston, MA1$687,2160$0
University Enterprises, IncorporatedSacramento, CA2$563,7050$0
Temple Univ of the CommonwealthPhiladelphia, PA2$523,3580$0
Duquesne UniversityPittsburgh, PA1$514,0000$0
Medical College of WisconsinMilwaukee, WI1$494,1600$0
Virginia Commonwealth UniversityRichmond, VA1$459,0160$0
Upstate Medical UniversitySyracuse, NY1$448,2500$0
University of California-RiversideRiverside, CA2$444,5720$0
University of California-Santa CruzSanta Cruz, CA1$443,1210$0
University of California, San FranciscoSan Francisco, CA1$435,8750$0
University of North Texas HLTH Sci CTRFort Worth, TX1$428,3480$0
Massachusetts Institute of TechnologyCambridge, MA1$426,5230$0
Albert Einstein College of MedicineBronx, NY1$417,5000$0
SUNY at BuffaloAmherst, NY1$199,3750$0
University of South FloridaTampa, FL1$187,5000$0
University of WashingtonSeattle, WA1$145,6740$0
Kansas State UniversityManhattan, KS1$143,4080$0
Salk Institute for Biological StudiesLa Jolla, CA1$118,3950$0
Wake Forest University Health SciencesWinston-Salem, NC1$75,5010$0
CUNY Graduate School University CenterNew York, NY1$68,2320$0
Rush University Medical CenterChicago, IL1$62,4650$0
Northwestern University at ChicagoChicago, IL1$44,7510$0
University of Oklahoma Norman CampusNorman, OK1$42,5740$0
Univ of North Carolina Chapel HillChapel Hill, NC1$41,6270$0
Gordon Research ConferencesEast Greenwich, RI1$15,0000$0

Funding by fiscal year

Fiscal yearNIH awardsNIH amountNSF awardsNSF amount
202565$34,771,7010$0
202478$39,217,3270$0
202382$41,547,5140$0
202265$34,065,2010$0
202171$34,824,1140$0

Open federal funding opportunities

From Grants.gov: notices that funded awards in this table, and open notices on the same agency and assistance listing.

Open opportunityNumberAgencyListingClosesAward ceilingWhy it matches
Developing novel theory and methods for understanding the genetic architecture of complex human traits (R01 Clinical Trial Not Allowed)PAR-25-255NIH93.242November 5, 2026Not listedSame assistance listing 93.242 as 43 awards here
Advancing Real-World Effectiveness Evidence for Rapid-Acting Psychotropic Interventional Drugs (RAPIDs)RFA-MH-27-150NIH93.242November 13, 2026Not listedSame assistance listing 93.242 as 43 awards here
Ethical, Legal and Social Implications (ELSI) Small Research Grant (R03 Clinical Trial Optional)PAR-25-370NIH93.242November 16, 2026$50,000Same assistance listing 93.242 as 43 awards here
Ethical, Legal and Social Implications (ELSI) Exploratory/Developmental Research Grant (R21 Clinical Trial Optional)PAR-25-369NIH93.242November 18, 2026Not listedSame assistance listing 93.242 as 43 awards here
Ethical, Legal and Social Implications (ELSI) Research (R01 Clinical Trial Optional)PAR-25-371NIH93.242November 18, 2026Not listedSame assistance listing 93.242 as 43 awards here
Seamless Early-Stage Clinical Drug Development (Phase 1 to 2a) for Novel therapeutic Agents for the Spectrum of Alzheimer's Disease (AD) and AD-related Dementias (ADRD) (UG3/UH3 Clinical Trial Required)PAR-25-226NIH93.242November 19, 2026Not listedSame assistance listing 93.242 as 43 awards here
Competing Revisions to Existing NIH Single Project Research Grants and Cooperative Agreements (Clinical Trial Optional)PA-23-317NIH93.242November 24, 2026Not listedSame assistance listing 93.242 as 43 awards here
Emerging Global Leader Award (K43 Independent Clinical Trial Required)PAR-24-295NIH93.242December 3, 2026Not listedSame assistance listing 93.242 as 43 awards here
Emerging Global Leader Award (K43 Independent Clinical Trial Not Allowed)PAR-24-296NIH93.242December 3, 2026Not listedSame assistance listing 93.242 as 43 awards here
NIH Research Software Engineer (RSE) Award (R50 Clinical Trials Not Allowed)RFA-OD-24-011NIH93.242December 4, 2026Not listedSame assistance listing 93.242 as 43 awards here
Academic Research Enhancement Award (AREA) for Undergraduate-Focused Institutions (R15 Clinical Trial Required)PAR-24-214NIH93.242January 7, 2027$375,000Same assistance listing 93.242 as 43 awards here
Personal Health Informatics for Delivering Actionable Insights to Individuals (R01 Clinical Trial Optional)PAR-25-235NIH93.242January 7, 2027$250,000Same assistance listing 93.242 as 43 awards here
Accelerating Solutions to Improve Access and Quality of Empirically-Supported Practices for Youth Mental Health (R01 Clinical Trial Optional)PAR-25-310NIH93.242January 7, 2027Not listedSame assistance listing 93.242 as 43 awards here
Intervention Research to Improve Native American Health (R34 Clinical Trial Optional)PAR-25-378NIH93.242January 7, 2027Not listedSame assistance listing 93.242 as 43 awards here
Intervention Research to Improve Native American Health (R01 Clinical Trial Optional)PAR-25-379NIH93.242January 7, 2027Not listedSame assistance listing 93.242 as 43 awards here
Biomedical Research Environment and Sponsored Programs Administration Development (BRE-SPAD) Program (UC2- Clinical Trial Not Allowed)PAR-24-268NIH93.242January 27, 2027$500,000Same assistance listing 93.242 as 43 awards here
BRAIN Initiative: Preclinical Proof of Concept for Novel Recording and Modulation Technologies in the Human CNS (R18 - Clinical Trial Not Allowed)RFA-NS-24-031NIH93.242January 28, 2027$750,000Same assistance listing 93.242 as 43 awards here
BRAIN Initiative: Development and Validation of Novel Tools to Probe Cell-Specific and Circuit-Specific Processes in the Brain (R01 Clinical Trial Not Allowed)RFA-MH-26-170NIH93.242February 8, 2027Not listedSame assistance listing 93.242 as 43 awards here
BRAIN Initiative: Exploratory Research Opportunities Using Invasive Neural Recording and Stimulating Technologies in the Human Brain (R61 Clinical Trial Not Allowed)RFA-DC-27-004NIH93.242February 11, 2027$700,000Same assistance listing 93.242 as 43 awards here
NLM Institutional Grants for Research Training in Biomedical Informatics, Data Science, and AI (T15 Independent Clinical Trial Not Allowed)RFA-LM-28-001NIH93.242February 11, 2027$775,000Same assistance listing 93.242 as 43 awards here

Updated November 3, 2026. Read from NIH RePORTER ExPORTER and NSF Award Search. Published by NIH and NSF as U.S. government data. NIH awards are fiscal years 2021 to 2025 (NIH files published to 2026-07-09); NSF awards are fiscal years 2022 to 2026 (NSF files published to 2026-11-02). NIH amounts are the total cost of each fiscal year in the window; NSF amounts are the funds obligated in the window. Organizations are matched on the UEI. Open opportunities come from Grants.gov and match on agency and assistance listing number, and on the notice number NIH prints on an award. Free to reuse with credit to SpecStream under CC BY 4.0. Spot a wrong value? Write to [email protected] with the link to this page.