Data / Research funding / Down Syndrome
Down Syndrome: 323 NIH awards ($624M) to 114 organizations
323 NIH awards ($624M) in the NIH spending category Down Syndrome, to 114 organizations, read 2026-11-04. NIH fiscal years 2021 to 2025.
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Awards
323 awards in the window.
| Award | Agency | Institute or division | Fiscal year | Amount in window | Start | End | Principal investigator | Source |
|---|---|---|---|---|---|---|---|---|
| Alzheimer Biomarker Consortium - Down Syndrome (ABC-DS) | NIH | National Institute on Aging | 2021 to 2025 | $82,684,947 | September 30, 2020 | August 31, 2026 | HANDEN, BENJAMIN L | reporter.nih.gov |
| NHLBI TRANS-OMICS FOR PRECISION MEDICINE (TOPMED) FOR THE CENTRALIZED OMICS RESOURCE (CORE) | NIH | National Heart, Lung, and Blood Institute | 2023 to 2025 | $31,474,131 | September 26, 2025 | September 25, 2026 | reporter.nih.gov | |
| The INCLUDE Data Coordinating Center | NIH | National Heart, Lung, and Blood Institute | 2021 to 2025 | $27,560,616 | September 26, 2020 | August 31, 2030 | RESNICK, ADAM CAIN | reporter.nih.gov |
| Supplement to TR01 Human cortical development and neural plasticity altered by trisomy 21 | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2021 to 2025 | $11,380,369 | September 10, 2021 | August 31, 2027 | BHATTACHARYYA, ANITA | reporter.nih.gov |
| The INCLUDE Project Down Syndrome Biorepository (DS-Biorepository) | NIH | National Institute on Aging | 2024 to 2025 | $10,436,444 | September 30, 2024 | August 31, 2029 | ESPINOSA, JOAQUIN M. | reporter.nih.gov |
| Public Health and Autism Science advancing Effectual Strategies across the life course (PHASES) | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2022 to 2025 | $8,623,178 | September 6, 2022 | August 31, 2027 | ROBINS, DIANA L | reporter.nih.gov |
| Randomized Control Trial of oxygen therapy in Children and Adolescents with Down Syndrome and Obstructive Sleep Apnea | NIH | National Heart, Lung, and Blood Institute | 2024 to 2025 | $8,481,225 | September 1, 2022 | August 31, 2027 | AMIN, RAOUF S. | reporter.nih.gov |
| Washington University Intellectual and Developmental Disabilities Research Center | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2021 to 2025 | $8,281,463 | July 28, 2020 | May 31, 2027 | DOUGHERTY, JOSEPH D | reporter.nih.gov |
| INCLUDE Down Syndrome Clinical Cohort Coordinating Center (DS-4C) | NIH | National Heart, Lung, and Blood Institute | 2024 to 2025 | $7,956,250 | September 20, 2024 | August 31, 2029 | HUNTER, JESSICA EZZELL | reporter.nih.gov |
| Institutional Career Development Core | NIH | National Center for Advancing Translational Sciences | 2021 to 2025 | $7,493,043 | June 1, 2017 | February 28, 2027 | MCKINNEY, CHRISTY MICHELLE | reporter.nih.gov |
| Randomized Control Trial of oxygen therapy in Children and Adolescents with Down Syndrome and Obstructive Sleep Apnea | NIH | National Heart, Lung, and Blood Institute | 2022 to 2023 | $7,285,275 | September 1, 2022 | August 31, 2024 | AMIN, RAOUF S. | reporter.nih.gov |
| A Longitudinal MRI Study Characterizing Very Early Brain Development in Infants with Down Syndrome | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2021 to 2024 | $6,871,845 | September 20, 2018 | August 31, 2025 | MARRUS, NATASHA | reporter.nih.gov |
| Clinical trials to prevent Alzheimer's Disease in Down Syndrome | NIH | National Institute on Aging | 2022 to 2024 | $6,863,895 | September 15, 2019 | August 31, 2025 | RAFII, MICHAEL S | reporter.nih.gov |
| Trisomy 21 and its impact on hedgehog-dependent gene regulation and differentiation timing | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2023 to 2024 | $5,112,898 | September 1, 2024 | March 31, 2026 | MOSKOWITZ, IVAN PAUL | reporter.nih.gov |
| Identifying the mechanisms of leukemia progression | NIH | National Cancer Institute | 2021 to 2025 | $5,032,279 | September 22, 2021 | August 31, 2028 | CRISPINO, JOHN D | reporter.nih.gov |
| Administrative supplement | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2023 to 2025 | $4,521,282 | September 1, 2023 | June 30, 2028 | FIDLER, DEBORAH J | reporter.nih.gov |
| JAK Inhibition in Down Syndrome | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases | 2022 to 2024 | $4,419,892 | September 25, 2019 | July 31, 2025 | ESPINOSA, JOAQUIN M. | reporter.nih.gov |
| NRSA Training Core | NIH | National Center for Advancing Translational Sciences | 2021 to 2025 | $4,317,682 | June 1, 2017 | February 28, 2027 | MOORE, MEGAN | reporter.nih.gov |
| Body Composition and Energy Expenditure in Youth with Spina Bifida | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2021 to 2024 | $4,224,862 | July 1, 2019 | November 30, 2025 | POLFUSS, MICHELE | reporter.nih.gov |
| Evaluating Assessment and Medication Treatment of ADHD in Children with Down Syndrome | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2022 to 2024 | $4,182,561 | May 1, 2024 | August 31, 2025 | ESBENSEN, ANNA J. | reporter.nih.gov |
| Institutional Career Development Core | NIH | National Center for Advancing Translational Sciences | 2021 to 2025 | $3,979,534 | September 7, 2017 | June 30, 2027 | NOLLEN, NICOLE L | reporter.nih.gov |
| Structure of amyloid fibrils in human neurodegenerative diseases and aging | NIH | National Institute of Neurological Disorders and Stroke | 2023 | $3,924,261 | September 30, 2018 | August 31, 2026 | VIDAL, RUBEN | reporter.nih.gov |
| DS-ARC: A Remote Digital Cognitive Assessment for Down Syndrome-Associated Alzheimer's Disease | NIH | National Institute on Aging | 2023 to 2024 | $3,901,583 | July 1, 2023 | March 31, 2028 | HASSENSTAB, JASON J | reporter.nih.gov |
| A Cognitive Test Battery for Intellectual Disabilities | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2021 to 2024 | $3,811,118 | September 22, 2014 | September 29, 2025 | HESSL, DAVID R | reporter.nih.gov |
| NHLBI TRANS-OMICS FOR PRECISION MEDICINE (TOPMED) FOR THE CENTRALIZED OMICS RESOURCE (CORE) | NIH | National Heart, Lung, and Blood Institute | 2023 to 2025 | $3,793,717 | September 23, 2025 | September 22, 2026 | reporter.nih.gov | |
| North Carolina Translational and Clinical Science Institute (NC TraCS) KL2 | NIH | National Center for Advancing Translational Sciences | 2021 to 2022 | $3,722,343 | March 30, 2018 | June 30, 2023 | WEINBERGER, MORRIS | reporter.nih.gov |
| Cardiogenesis: Molecular Mechanisms | NIH | National Heart, Lung, and Blood Institute | 2021 to 2025 | $3,717,603 | January 10, 1997 | May 31, 2028 | SRIVASTAVA, DEEPAK | reporter.nih.gov |
| Emulating Immune Dysregulation by Trisomy 21 in a Multi-Organ-on-a-Chip System | NIH | National Heart, Lung, and Blood Institute | 2021 to 2025 | $3,649,414 | September 20, 2021 | July 31, 2026 | HAJIPOURAN BENAM, KAMBEZ | reporter.nih.gov |
| SPEECH PERCEPTION AND AUDITORY ABILITIES IN INFANTS, CHILDREN, AND ADULTS WITH DOWN SYNDROME | NIH | National Institute on Deafness and Other Communication Disorders | 2022 to 2025 | $3,582,608 | June 1, 2022 | May 31, 2027 | LEIBOLD, LORI J. | reporter.nih.gov |
| Auditory function, cognition, language and brain structure in Down Syndrome- Admin Supplement | NIH | National Institute on Deafness and Other Communication Disorders | 2022 to 2025 | $3,424,585 | January 15, 2022 | December 31, 2026 | LITOVSKY, RUTH Y | reporter.nih.gov |
| Why do Down Syndrome patients have high risk of Hirschsprung disease? | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2022 to 2025 | $3,330,453 | September 15, 2022 | July 31, 2027 | CHAKRAVARTI, ARAVINDA | reporter.nih.gov |
| Type I IFN signaling during lung development in Down Syndrome | NIH | National Heart, Lung, and Blood Institute | 2021 to 2025 | $3,274,532 | September 17, 2021 | June 30, 2027 | DANOPOULOS, SOULA ATHANASIA | reporter.nih.gov |
| Novel computational strategies to deconvolute co-occurring conditions in Down syndrome | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2022 to 2025 | $3,246,817 | September 9, 2022 | August 31, 2027 | COSTELLO, JAMES CHRISTOPHER | reporter.nih.gov |
| Early Cognitive Decline in Down Syndrome | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2021 to 2024 | $3,165,808 | July 15, 2020 | June 30, 2026 | CONNERS, FRANCES A | reporter.nih.gov |
| Mechanistic and functional dissection of inflammaging in Down syndrome | NIH | National Institute of Allergy and Infectious Diseases | 2022 to 2025 | $3,165,277 | September 1, 2022 | August 31, 2027 | KHOR, BERNARD | reporter.nih.gov |
| Lifestyle and Alzheimer's Disease In Down Syndrome | NIH | National Institute on Aging | 2021 to 2024 | $3,112,783 | September 15, 2020 | August 31, 2025 | HARTLEY, SIGAN L | reporter.nih.gov |
| Cerebrovascular contributions to Alzheimer's disease in adults with Down Syndrome | NIH | National Institute on Aging | 2022 | $3,079,273 | September 30, 2022 | August 31, 2025 | BRICKMAN, ADAM M | reporter.nih.gov |
| Predoctoral Training Program in Signaling and Cellular Regulation | NIH | National Institute of General Medical Sciences | 2021 to 2025 | $3,053,360 | July 1, 2021 | June 30, 2026 | AHN, NATALIE G. | reporter.nih.gov |
| Effects of Hypoglossal Nerve Stimulation on Cognition & Language in Down Syndrome | NIH | National Institute on Deafness and Other Communication Disorders | 2021 to 2024 | $2,960,609 | September 15, 2020 | August 31, 2026 | HARTNICK, CHRISTOPHER J | reporter.nih.gov |
| Cognitive Outcome Measures in School Age Children with Down Syndrome (ECODS) | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2021 to 2025 | $2,945,851 | July 20, 2018 | June 30, 2029 | ESBENSEN, ANNA J. | reporter.nih.gov |
| Cell and Network Disruptions and Associated Pathogenenesis in Tauopathy and Down Syndrome | NIH | National Institute on Aging | 2021 to 2024 | $2,943,744 | April 15, 2020 | March 31, 2026 | FINKBEINER, STEVEN M | reporter.nih.gov |
| The Infant Down Syndrome Brain and Behavior Study | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2024 | $2,927,457 | September 20, 2024 | May 31, 2029 | MARRUS, NATASHA | reporter.nih.gov |
| Commercialization of Selective Dyrk1a Inhibitors for Down Syndrome | NIH | National Institute of Neurological Disorders and Stroke | 2024 to 2025 | $2,924,902 | September 15, 2022 | August 31, 2027 | DUNCKLEY, TRAVIS | reporter.nih.gov |
| Predoctoral Training in Molecular and Cellular Biology | NIH | National Institute of General Medical Sciences | 2021 to 2025 | $2,884,438 | July 1, 2020 | June 30, 2030 | PREKERIS, RYTIS | reporter.nih.gov |
| Centriole assembly and function for centrosome and cilia biology | NIH | National Institute of General Medical Sciences | 2021 to 2025 | $2,869,745 | June 1, 2021 | March 31, 2026 | PEARSON, CHAD G | reporter.nih.gov |
| Defining the Role of Enteric Nervous System Dysfunction in Gastrointestinal Motor and Sensory Abnormalities in Down Syndrome | NIH | National Institute of Neurological Disorders and Stroke | 2023 | $2,837,478 | May 1, 2023 | April 30, 2026 | BELKIND-GERSON, JAIME | reporter.nih.gov |
| Generation and analysis of new mouse models to determine novel therapeutic targets for Down syndrome-associated cognitive deficits | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2022 to 2025 | $2,832,381 | September 13, 2022 | August 31, 2027 | YU, EUGENE | reporter.nih.gov |
| Behavior Measure for Children and Adolescents with Down Syndrome | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2022 to 2025 | $2,802,179 | September 15, 2022 | August 31, 2027 | ESBENSEN, ANNA J. | reporter.nih.gov |
| Metabolic Health, Lifestyle, and Risk of Co-Occurring Health Conditions in Down Syndrome (MET-DS) | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2024 | $2,800,027 | September 17, 2024 | May 31, 2029 | HARTLEY, SIGAN L | reporter.nih.gov |
| Self-Supporting Nasopharyngeal Airway (ssNPA) Treating Upper Airway Obstruction in Hypotonia | NIH | National Heart, Lung, and Blood Institute | 2022 to 2025 | $2,798,300 | September 1, 2021 | August 31, 2027 | O'BRIEN, LOUISE M. | reporter.nih.gov |
| Molecular mechanism of dysregulated airway antiviral responses in children with Trisomy 21 | NIH | National Heart, Lung, and Blood Institute | 2021 to 2025 | $2,785,088 | August 15, 2021 | July 31, 2026 | NINO, GUSTAVO | reporter.nih.gov |
| Understanding the skeleton in Down Syndrome | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2021 to 2025 | $2,772,646 | June 1, 2024 | May 31, 2027 | SUVA, LARRY J. | reporter.nih.gov |
| New Down syndrome brain organization revealed by single-cell genomics | NIH | National Institute on Aging | 2021 to 2022 | $2,758,286 | September 15, 2021 | June 30, 2024 | CHUN, JEROLD | reporter.nih.gov |
| Mechanisms of DMP Development and Atrioventricular Septation | NIH | National Heart, Lung, and Blood Institute | 2021 to 2025 | $2,723,098 | September 1, 2014 | August 31, 2027 | WESSELS, ARNO | reporter.nih.gov |
| Mechanisms of Down syndrome-associated swallowing dysfunction in mouse models | NIH | National Institute on Deafness and Other Communication Disorders | 2022 to 2025 | $2,721,607 | June 13, 2022 | May 31, 2027 | CONNOR, NADINE P | reporter.nih.gov |
| Down Syndrome: Toward Optimal Trajectories and Health Equity using Medicaid Analytic eXtract (DS -TO-THE-MAX) | NIH | National Institute on Aging | 2021 to 2024 | $2,708,622 | September 30, 2021 | August 31, 2025 | RUBENSTEIN, ERIC S | reporter.nih.gov |
| Human Trisome Project - Latin America Network | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2024 | $2,693,143 | September 20, 2024 | May 31, 2029 | ESPINOSA, JOAQUIN M. | reporter.nih.gov |
| Structural characterization of tau conformational heterogeneity in Down syndrome | NIH | National Institute of Neurological Disorders and Stroke | 2023 to 2025 | $2,686,309 | August 1, 2025 | July 31, 2026 | SOUTHWORTH, DANIEL RYLAND | reporter.nih.gov |
| Obesity Prevention Targets for Down Syndrome | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2022 to 2025 | $2,679,116 | September 3, 2022 | August 31, 2027 | DAUNHAUER, LISA ANN | reporter.nih.gov |
| Down Syndrome Early Childhood Omics, Deep Phenotyping, and Epidemiology in Texas: DECODE IT Cohort | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2024 | $2,644,869 | September 17, 2024 | May 31, 2029 | LUPO, PHILIP | reporter.nih.gov |
| Transdiagnostic Associations Across Developmental Disorders | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2022 to 2025 | $2,639,347 | September 9, 2022 | July 31, 2027 | GRIGORENKO, ELENA L | reporter.nih.gov |
| Neurovascular unit dysfunction in Down syndrome revealed by TBI | NIH | National Institute of Neurological Disorders and Stroke | 2022 | $2,601,812 | September 7, 2022 | August 31, 2025 | HUANG, MINGXIA | reporter.nih.gov |
| REPOSITORY OF MOUSE MODELS FOR CYTOGENETIC RESEARCH | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2021 to 2024 | $2,600,000 | September 22, 2020 | September 21, 2025 | LUTZ, CATHLEEN | reporter.nih.gov |
| Advancing the Lives & HeaLth of Youth and Young Adults with Down Syndrome (ALLY-DS) | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2024 | $2,598,199 | September 17, 2024 | May 31, 2029 | KELLY, ANDREA BRIDGET | reporter.nih.gov |
| Precision Medicine for Inflammatory Treatment for Alzheimer's Disease in Down Syndrome | NIH | National Institute on Aging | 2021 to 2022 | $2,578,790 | September 30, 2021 | August 31, 2024 | RISSMAN, ROBERT | reporter.nih.gov |
| Sleep Spindle Dynamics as a Clinical Biomarker of Aging, Alzheimer's Disease, and Trisomy 21 | NIH | National Institute on Aging | 2023 | $2,576,936 | September 15, 2023 | August 31, 2026 | PRERAU, MICHAEL J | reporter.nih.gov |
| Executive Function Outcome Measures for Young Children with Down Syndrome | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2021 to 2023 | $2,565,709 | September 13, 2019 | June 30, 2025 | FIDLER, DEBORAH J | reporter.nih.gov |
| A Human iPSC-Based Chimeric Mouse Model of Alzheimers Disease in Down Syndrome | NIH | National Institute on Aging | 2021 to 2024 | $2,549,299 | September 30, 2021 | August 31, 2026 | JIANG, PENG | reporter.nih.gov |
| Aberrant chromatin regulatory mechanisms in Down syndrome brain | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2021 to 2025 | $2,510,790 | September 18, 2024 | August 31, 2029 | MAZE, IAN S. | reporter.nih.gov |
| Treatment of Obstructive Sleep Apnea with Personalized Surgery in Children with Down Syndrome (TOPS-DS) | NIH | National Heart, Lung, and Blood Institute | 2022 to 2023 | $2,502,563 | September 7, 2022 | July 31, 2025 | LAM, DEREK J | reporter.nih.gov |
| Beyond Gene Dosage: Understanding Down Syndrome via 4D Genome Organization | NIH | National Heart, Lung, and Blood Institute | 2021 to 2024 | $2,496,816 | September 18, 2020 | August 31, 2025 | LI, WENBO | reporter.nih.gov |
| Mechanistic investigation of therapies for Down Syndrome Regression Disorder | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2024 to 2025 | $2,478,448 | September 1, 2024 | August 31, 2027 | ESPINOSA, JOAQUIN M. | reporter.nih.gov |
| Septhohippocamal connectome dysfunction in Down syndrome associated with Alzheimer’s disease pathophysiology | NIH | National Institute on Aging | 2023 | $2,466,001 | February 15, 2023 | January 31, 2026 | GINSBERG, STEPHEN D | reporter.nih.gov |
| The Promotion of Physical Activity for the Prevention of Alzheimer's Disease in Adults with Down Syndrome | NIH | National Institute on Aging | 2021 to 2023 | $2,444,707 | August 1, 2019 | April 30, 2025 | PTOMEY, LAUREN TAYLOR | reporter.nih.gov |
| Down Syndrome Connect Registry | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2024 to 2025 | $2,428,283 | June 15, 2024 | June 14, 2026 | ESPINOSA, JOAQUIN M. | reporter.nih.gov |
| Tongue maturation deficits in a mouse model of Down syndrome | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2021 to 2025 | $2,366,038 | September 22, 2021 | August 31, 2026 | GLASS, TIFFANY | reporter.nih.gov |
| Development and Validation of the Down Syndrome Regression Rating Scales | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2023 to 2025 | $2,364,101 | September 20, 2023 | August 31, 2028 | BROWN, RUTH C | reporter.nih.gov |
| Understanding neuronal dysfunction in Down Syndrome using assembloids and xenotransplanted cortical organoids | NIH | National Institute on Aging | 2024 | $2,357,335 | September 30, 2024 | August 31, 2027 | ZELDICH, ELLA | reporter.nih.gov |
| Antisense Oligonucleotides targeting APP to prevent neurodegeneration in models of Down Syndrome and Alzheimer's disease | NIH | National Institute on Aging | 2021 to 2023 | $2,346,855 | April 15, 2019 | January 31, 2025 | MOBLEY, WILLIAM C | reporter.nih.gov |
| A Randomized Intervention Trial to Increase Access to Reproductive Health Services among Adolescents and Young Adults with intellectual and Developmental Disabilities | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2023 to 2025 | $2,326,180 | February 2, 2023 | January 31, 2028 | MCDERMOTT, SUZANNE W | reporter.nih.gov |
| Language and Executive Function in Females with ASD or FXS | NIH | National Institute on Deafness and Other Communication Disorders | 2023 to 2025 | $2,299,215 | September 1, 2023 | June 30, 2028 | STERLING, AUDRA MARIE | reporter.nih.gov |
| Investigating and targeting apolipoprotein E4 in Down syndrome-associated Alzheimer's disease | NIH | National Institute on Aging | 2023 | $2,282,487 | July 15, 2023 | June 30, 2026 | JOHNSON, NOAH RAY | reporter.nih.gov |
| Suppressing Aneuploidy-associated phenotypes in Down syndrome | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2022 to 2025 | $2,274,818 | September 1, 2022 | August 31, 2027 | TORRES, EDUARDO MARTIN | reporter.nih.gov |
| Trisomy 21 Model Atlas | NIH | Office of the Director, National Institutes of Health | 2023 to 2025 | $2,259,564 | September 19, 2023 | August 31, 2027 | GALBRAITH, MATTHEW D | reporter.nih.gov |
| Down Syndrome: a potential treatment XISTs | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2022 to 2025 | $2,258,071 | September 1, 2022 | August 31, 2027 | SHEEN, VOLNEY L | reporter.nih.gov |
| Chronic Health Conditions in Survivors of Down Syndrome-Associated Leukemia | NIH | National Cancer Institute | 2022 to 2025 | $2,251,638 | June 20, 2022 | May 31, 2028 | GRAMATGES, MARIA MONICA | reporter.nih.gov |
| A mosaic Down syndrome model system comparing isogenic trisomic/disomic cells to unmask trisomy-21 related genomic, epigenomic, and senescence changes acquired across the lifespan | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2023 | $2,217,370 | May 1, 2023 | April 30, 2026 | JACKSON-COOK, COLLEEN K | reporter.nih.gov |
| The role of immune deregulation and NGF dysmetabolism in the development of Alzheimer disease in individuals with Down syndrome | NIH | National Institute on Aging | 2024 to 2025 | $2,167,125 | August 15, 2024 | July 31, 2029 | BUSCIGLIO, JORGE A | reporter.nih.gov |
| Defining the Role of DNA Rereplication of Chromosome 21 in the Development and Pathophysiology of Down Syndrome | NIH | National Institute of Allergy and Infectious Diseases | 2021 to 2024 | $2,113,500 | January 4, 2021 | March 31, 2025 | BLACK, JOSHUA CRANSTON | reporter.nih.gov |
| Investigating monocyte dysfunction in Down Syndrome | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases | 2021 to 2023 | $2,109,849 | July 24, 2019 | December 31, 2024 | HAMERMAN, JESSICA A | reporter.nih.gov |
| Altered Hippocampal Neurogenesis and Cognition via Maneb-mediated Changes in the Thiol Redox Proteome. | NIH | National Institute of Environmental Health Sciences | 2021 to 2023 | $2,104,664 | March 1, 2017 | February 28, 2026 | ROEDE, JAMES R | reporter.nih.gov |
| Function of RUNX1 in diverse Down syndrome tissues | NIH | National Heart, Lung, and Blood Institute | 2021 to 2023 | $2,081,565 | September 1, 2023 | August 31, 2024 | ALLEN, MARY A | reporter.nih.gov |
| Positive Airway Pressure For The Treatment Of The Obstructive Sleep Apnea Syndrome In Children With Down Syndrome | NIH | National Heart, Lung, and Blood Institute | 2021 to 2022 | $2,055,867 | September 23, 2019 | June 30, 2023 | TAPIA, IGNACIO ESTEBAN | reporter.nih.gov |
| Institutional Career Development Core | NIH | National Center for Advancing Translational Sciences | 2021 to 2022 | $2,049,015 | May 18, 2018 | June 30, 2023 | ROBB, SHERI L | reporter.nih.gov |
| The Impact of Weight Loss on Alzheimer's Disease Risk in Adults with Down Syndrome | NIH | National Institute on Aging | 2024 to 2025 | $2,048,156 | September 1, 2022 | August 31, 2027 | PTOMEY, LAUREN TAYLOR | reporter.nih.gov |
| Investigating epigenetic mechanisms in Down syndrome using human cellular models | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2023 | $2,034,753 | April 5, 2023 | March 31, 2026 | BARRETT, LINDY ELISE | reporter.nih.gov |
| The role of APP in neurogenesis and AD in Down syndrome | NIH | National Institute on Aging | 2022 | $2,005,131 | September 15, 2022 | August 31, 2025 | LAZAROV, ORLY | reporter.nih.gov |
| Identification of optimum spectacle prescriptions for patients with Down syndrome | NIH | National Eye Institute | 2021 to 2025 | $1,964,065 | September 1, 2014 | June 30, 2027 | ANDERSON, HEATHER ANNE | reporter.nih.gov |
| SIM2 Regulation of Mitochondrial Dysfunction in Down Syndrome | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2023 | $1,960,246 | September 13, 2023 | August 31, 2026 | PORTER, WESTON W | reporter.nih.gov |
| Trophoblast progenitor heterogeneity and function in normal and Trisomy 21-affected placentae | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2023 to 2025 | $1,959,382 | September 20, 2023 | June 30, 2028 | PARAST, MANA M | reporter.nih.gov |
| A Physiologically Integrated Approach to Studying Mechanisms of Speech Production and Swallow Function in Down Syndrome | NIH | National Institute on Deafness and Other Communication Disorders | 2023 | $1,959,062 | April 15, 2023 | March 31, 2026 | WILKINSON, KRISTA M | reporter.nih.gov |
| Multidimensional investigation of auditory dysfunction in Down syndrome | NIH | National Institute on Deafness and Other Communication Disorders | 2024 to 2025 | $1,942,611 | May 3, 2024 | April 30, 2029 | ESPINOSA, JOAQUIN M. | reporter.nih.gov |
| A Novel Approach to Molecular Cell Pathologies of Human Down Syndrome and DS-AD | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2021 to 2023 | $1,938,999 | September 12, 2017 | March 31, 2026 | LAWRENCE, JEANNE BENTLEY | reporter.nih.gov |
| Mediator kinases as interferon antagonists in Down Syndrome | NIH | National Institute of Allergy and Infectious Diseases | 2021 to 2024 | $1,912,701 | September 22, 2020 | August 31, 2025 | TAATJES, DYLAN J | reporter.nih.gov |
| Brain Development in Down Syndrome during Fetal and Early Postnatal Ages | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2024 | $1,896,457 | September 18, 2024 | August 31, 2027 | TAKAHASHI (OKI), EMI | reporter.nih.gov |
| Sleep abnormalities in Down Syndrome-related Alzheimer's disease | NIH | National Institute on Aging | 2023 to 2025 | $1,890,530 | September 15, 2023 | May 31, 2028 | HOEFFER, CHARLES A | reporter.nih.gov |
| Targeting protein synthesis dysregulation in Down syndrome-associated cognitive impairment with aging | NIH | National Institute on Aging | 2021 to 2024 | $1,872,483 | September 15, 2021 | August 31, 2026 | MA, TAO | reporter.nih.gov |
| Sleep and Temperature Disturbance as risk factors for Alzheimer's Disease in Down Syndrome: a Longitudinal Study | NIH | National Institute on Aging | 2023 | $1,871,190 | February 1, 2023 | January 31, 2026 | BLESSING, ESTHER MARIAN | reporter.nih.gov |
| Restoration of proteostasis to address co-occurring conditions in Down Syndrome | NIH | National Institute on Aging | 2022 | $1,856,328 | September 15, 2022 | August 31, 2025 | NAIDOO, NIRMALA NIRINJINI | reporter.nih.gov |
| Default mode network dysfunction in Down Syndrome | NIH | National Institute on Aging | 2023 | $1,844,755 | April 15, 2023 | March 31, 2026 | MUFSON, ELLIOTT JAY | reporter.nih.gov |
| Molecular mechanisms of oral deficiencies in Down syndrome | NIH | National Institute of Dental & Craniofacial Research | 2023 to 2024 | $1,836,183 | September 18, 2024 | June 30, 2025 | LACRUZ, RODRIGO S. | reporter.nih.gov |
| Institutional Career Development Core | NIH | National Center for Advancing Translational Sciences | 2021 to 2022 | $1,826,730 | May 1, 2018 | January 31, 2024 | BURNHAM, ELLEN L | reporter.nih.gov |
| Redox and Ca2+ signaling regulation of enamel mineralization | NIH | National Institute of Dental & Craniofacial Research | 2021 to 2025 | $1,769,342 | March 10, 2023 | February 28, 2028 | LACRUZ, RODRIGO S. | reporter.nih.gov |
| Develop and Validate a Mouse Model for Alzheimer Disease in Down Syndrome | NIH | National Institute of Neurological Disorders and Stroke | 2024 | $1,698,323 | August 15, 2024 | July 31, 2027 | MOBLEY, WILLIAM C | reporter.nih.gov |
| Home sleep apnea testing compared to in-lab polysomnography for the evaluation of obstructive sleep apnea in children | NIH | National Heart, Lung, and Blood Institute | 2023 to 2025 | $1,690,819 | August 1, 2022 | July 31, 2027 | CIELO, CHRISTOPHER MICHAEL | reporter.nih.gov |
| Lens β-Amyloid Biomarker for Early Detection of Preclinical Alzheimer's Disease in the Framingham Study | NIH | National Institute on Aging | 2021 | $1,682,982 | April 1, 2021 | March 31, 2025 | GOLDSTEIN, LEE E. | reporter.nih.gov |
| Center for Aging and Policy Studies | NIH | National Institute on Aging | 2021 to 2024 | $1,681,251 | July 15, 2020 | June 30, 2025 | MONTEZ, JENNIFER KARAS | reporter.nih.gov |
| Understanding Down Syndrome Brain Development Using Human iPSC-Based Mouse Chimeras | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2024 | $1,671,510 | March 1, 2021 | December 31, 2026 | JIANG, PENG | reporter.nih.gov |
| Large-scale Genetic Investigation and Drug Discovery to Counteract Down Syndrome Neural Deficits | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2024 to 2025 | $1,664,159 | June 5, 2024 | May 31, 2029 | THYME, SUMMER B | reporter.nih.gov |
| Understanding proteome remodeling in aneuploidy | NIH | National Institute of General Medical Sciences | 2021 to 2024 | $1,661,174 | June 1, 2020 | May 31, 2025 | LIU, YANSHENG | reporter.nih.gov |
| Molecular epidemiology of acute lymphoblastic leukemia in children with Down syndrome | NIH | National Cancer Institute | 2023 to 2024 | $1,645,759 | August 3, 2020 | July 31, 2025 | RABIN, KAREN R | reporter.nih.gov |
| Determining cell-specific mechanisms that drive aberrant bone regeneration in Down syndrome | NIH | National Institute on Aging | 2023 | $1,633,451 | September 1, 2023 | August 31, 2026 | DAWSON, LINDSAY A | reporter.nih.gov |
| Evaluation of Hedgehog signaling-dependent heart development in a mouse model of Down Syndrome | NIH | National Heart, Lung, and Blood Institute | 2021 to 2023 | $1,632,091 | December 26, 2022 | May 31, 2024 | MOSKOWITZ, IVAN PAUL | reporter.nih.gov |
| Understanding Epigenetic Regulation of Copy Number Heterogeneity | NIH | National Institute of General Medical Sciences | 2021 to 2025 | $1,601,692 | August 1, 2018 | November 30, 2026 | FORD, HEIDE L. | reporter.nih.gov |
| Respiratory morbidity during the pandemic time in individuals with Down syndrome | NIH | National Institute of Allergy and Infectious Diseases | 2021 to 2024 | $1,598,637 | February 12, 2019 | January 31, 2026 | WU, PINGSHENG | reporter.nih.gov |
| Proteostasis dysregulation and the development of Alzheimer's-like neurodegeneration and dementia in Down syndrome | NIH | National Institute on Aging | 2023 to 2025 | $1,585,822 | December 1, 2022 | November 30, 2027 | PRATICO, DOMENICO | reporter.nih.gov |
| Mechanistic investigation of therapies for Down Syndrome Regression Disorder | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2022 to 2023 | $1,545,428 | September 9, 2022 | June 30, 2024 | ESPINOSA, JOAQUIN M. | reporter.nih.gov |
| Human Immune System Humanized Modeling of Down Syndrome Immune Responses to Pluripotent Stem Cells | NIH | National Institute of Allergy and Infectious Diseases | 2025 | $1,488,578 | September 16, 2025 | August 31, 2027 | BROWN, MATTHEW E | reporter.nih.gov |
| Mechanisms of White Matter Development in Down Syndrome | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2022 | $1,468,788 | April 1, 2018 | March 31, 2023 | HAYDAR, TARIK F | reporter.nih.gov |
| Microglial contribution to Down Syndrome Neuropathology | NIH | National Institute of Neurological Disorders and Stroke | 2023 to 2025 | $1,465,778 | January 1, 2023 | December 31, 2027 | COUFAL, NICOLE GABRIELE | reporter.nih.gov |
| Endosome Dysfunction in Alzheimer's Disease | NIH | National Institute on Aging | 2021 to 2022 | $1,438,113 | September 30, 2018 | May 31, 2025 | NIXON, RALPH A. | reporter.nih.gov |
| Risk for Severe/Profound Intellectual Disability in Down Syndrome | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2024 to 2025 | $1,408,681 | September 4, 2024 | August 31, 2029 | FIDLER, DEBORAH J | reporter.nih.gov |
| Integrating Epidemiologic and Genomic Data to Elucidate the Genetic Overlap Between Congenital Anomalies and Pediatric Cancer | NIH | National Cancer Institute | 2023 to 2025 | $1,394,210 | September 19, 2023 | August 31, 2028 | HUFF, CHAD DANIEL | reporter.nih.gov |
| Novel roles for the Alzheimer's Disease (AD) risk gene, SORLA in neuroprotection in AD | NIH | National Institute on Aging | 2021 to 2022 | $1,362,387 | September 30, 2018 | May 31, 2024 | HUANG, TIMOTHY YIKAI | reporter.nih.gov |
| Executive Function Intervention for Young Children with Down Syndrome | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2024 to 2025 | $1,357,878 | July 10, 2024 | June 30, 2026 | FIDLER, DEBORAH J | reporter.nih.gov |
| Mechanisms for cell signaling in the control of cardiomyogenesis | NIH | National Heart, Lung, and Blood Institute | 2022 to 2025 | $1,352,193 | August 1, 2016 | August 31, 2026 | SONG, KUNHUA | reporter.nih.gov |
| Establishing an Alzheimer’s disease biomarker clock in Down syndrome using positron emission tomography and plasma analytes | NIH | National Institute on Aging | 2025 | $1,346,873 | September 15, 2025 | August 31, 2029 | ZAMMIT, MATTHEW | reporter.nih.gov |
| Nuclear-Metabolic Interplay in Down syndrome | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2024 to 2025 | $1,333,586 | July 15, 2024 | April 30, 2029 | MEHARENA, HIRUY SIBHATU | reporter.nih.gov |
| Modifiers of Down Syndrome Co-occurring Phenotypes | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2025 | $1,303,054 | August 1, 2025 | July 31, 2027 | ROPER, RANDALL J | reporter.nih.gov |
| Transposable Element Mobilization and Disrupted Translational Machinery in Down Syndrome | NIH | National Institute of Neurological Disorders and Stroke | 2025 | $1,274,904 | August 1, 2025 | July 31, 2027 | KALISH, BRIAN | reporter.nih.gov |
| DLK1 as a novel target for Down syndrome myeloid leukemia | NIH | National Cancer Institute | 2025 | $1,273,073 | September 3, 2025 | August 31, 2027 | GOPALAKRISHNAPILLAI, ANILKUMAR | reporter.nih.gov |
| Medications for Obstructive Sleep Apnea to Improve Cognition in Children with Down Syndrome (MOSAIC DS) | NIH | National Heart, Lung, and Blood Institute | 2022 to 2025 | $1,267,572 | September 15, 2019 | August 31, 2026 | COMBS, DANIEL | reporter.nih.gov |
| Non-invasive biometric screening for cerebrovascular disorders in persons with Down syndrome. | NIH | National Heart, Lung, and Blood Institute | 2021 to 2025 | $1,267,566 | February 17, 2021 | January 31, 2026 | SANTORO, JONATHAN DOUGLAS | reporter.nih.gov |
| Treatment of Obstructive Sleep Apnea with Personalized Surgery in Children with Down Syndrome (TOPS-DS) | NIH | National Heart, Lung, and Blood Institute | 2025 | $1,265,140 | September 7, 2022 | August 31, 2028 | LAM, DEREK J | reporter.nih.gov |
| A humanized monoclonal FSH antibody for Alzheimer's Disease and co-occurring health conditions in Down Syndrome | NIH | National Institute on Aging | 2025 | $1,257,163 | July 1, 2025 | June 30, 2030 | GOOSENS, KI ANN | reporter.nih.gov |
| Cellular Senescence in Trisomy 21 lung disease | NIH | National Heart, Lung, and Blood Institute | 2024 to 2025 | $1,236,223 | September 1, 2024 | June 30, 2028 | AL ALAM, DENISE | reporter.nih.gov |
| Precision Medicine for Inflammatory Treatment for Alzheimer's Disease in Down Syndrome | NIH | National Institute on Aging | 2024 to 2025 | $1,227,813 | September 30, 2021 | August 31, 2026 | RISSMAN, ROBERT | reporter.nih.gov |
| Transitions in the acquisition of language in kids with Down Syndrome | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2025 | $1,192,567 | August 1, 2025 | May 31, 2030 | THURMAN, ANGELA JOHN | reporter.nih.gov |
| GM-CSF/sargramostim treatment to improve cognition in Down syndrome | NIH | National Institute on Aging | 2021 to 2022 | $1,182,458 | September 30, 2021 | August 31, 2024 | POTTER, HUNTINGTON | reporter.nih.gov |
| Treating with Gamma-Secretase Modulators to Prevent Neurodegeneration in Mouse Models of Down Syndrome and Alzheimer Disease | NIH | National Institute on Aging | 2021 to 2022 | $1,169,165 | May 1, 2018 | January 31, 2024 | MOBLEY, WILLIAM C | reporter.nih.gov |
| Predoctoral Training Grant in Pharmacology INCLUDE Down Syndrome Supplement | NIH | National Institute of General Medical Sciences | 2021 to 2023 | $1,168,838 | July 1, 1978 | June 30, 2024 | DELL'ACQUA, MARK L | reporter.nih.gov |
| Early childhood communication outcome measures for DS | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2021 to 2022 | $1,167,279 | July 15, 2018 | May 31, 2024 | THURMAN, ANGELA JOHN | reporter.nih.gov |
| Persistent Post-Viral State of Bacterial Pneumonia Susceptibility and Severity in Down Syndrome | NIH | National Institute of Allergy and Infectious Diseases | 2021 to 2023 | $1,166,250 | June 1, 2019 | May 31, 2024 | YEAGER, MICHAEL E. | reporter.nih.gov |
| A biopsychosocial approach to the deep phenotyping of communicative participation in adolescents with Down syndrome | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2024 to 2025 | $1,155,838 | August 1, 2024 | June 30, 2029 | WHITE, MEGHAN DARLING | reporter.nih.gov |
| Dissecting the impact of interferon hypersensitivity on mouse models of Down syndrome | NIH | National Institute of Allergy and Infectious Diseases | 2021 to 2023 | $1,152,264 | June 1, 2019 | May 31, 2024 | SULLIVAN, KELLY D. | reporter.nih.gov |
| Translational Epigenetics with XIST: Silencing Trisomy in Human Organoid and Mouse Models of Down Syndrome | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2021 to 2022 | $1,118,382 | September 19, 2018 | June 30, 2025 | LAWRENCE, JEANNE BENTLEY | reporter.nih.gov |
| The Impact of Weight Loss on Alzheimer's Disease Risk in Adults with Down Syndrome | NIH | National Institute on Aging | 2022 to 2023 | $1,101,901 | September 30, 2022 | August 31, 2024 | PTOMEY, LAUREN TAYLOR | reporter.nih.gov |
| Identify common mechanisms of neurodegeneration between Alzheimer's disease and Down syndrome | NIH | National Institute on Aging | 2021 to 2022 | $1,091,979 | September 15, 2018 | May 31, 2025 | VELAZQUEZ, RAMON | reporter.nih.gov |
| Preventing Fatal Infections in Children with Down Syndrome During Treatment for Acute Lymphoblastic Leukemia | NIH | National Cancer Institute | 2024 to 2025 | $1,082,098 | June 1, 2024 | May 31, 2029 | RYEOM, SANDRA | reporter.nih.gov |
| Home Grown: A family-based lifestyle intervention to support healthy development of young children with Down syndrome | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2025 | $1,017,548 | August 7, 2025 | July 31, 2027 | WILLIS, ERIK A | reporter.nih.gov |
| Molecular regulators of GABAergic systems that underlie comorbidities in Down syndrome | NIH | National Institute of Neurological Disorders and Stroke | 2024 to 2025 | $1,010,880 | July 1, 2024 | May 31, 2029 | YE, BING | reporter.nih.gov |
| Positive Airway Pressure For The Treatment Of The Obstructive Sleep Apnea Syndrome In Children With Down Syndrome | NIH | National Heart, Lung, and Blood Institute | 2023 | $986,540 | September 1, 2023 | August 31, 2025 | TAPIA, IGNACIO ESTEBAN | reporter.nih.gov |
| Cell and Molecular Consequences of Alzheimer's Disease Genetic Variants on BBB Integrity and Function | NIH | National Institute of Neurological Disorders and Stroke | 2024 | $908,817 | September 15, 2020 | August 31, 2025 | YOUNG-PEARSE, TRACY L | reporter.nih.gov |
| INCLUDE Clinical Researcher Training (ICRT) | NIH | National Institute on Aging | 2025 | $866,506 | September 20, 2025 | August 31, 2027 | SCHATTEN, GERALD | reporter.nih.gov |
| Intrinsic and Extrinsic Factors Contributing to Trisomy 21 Preleukemia | NIH | National Cancer Institute | 2024 to 2025 | $853,838 | May 3, 2024 | April 30, 2029 | WAGENBLAST, ELVIN | reporter.nih.gov |
| Role of Piezo1-controlled Prox1 Modification in Lymphatic Valve Formation | NIH | National Heart, Lung, and Blood Institute | 2025 | $808,121 | May 15, 2025 | September 30, 2025 | CHOI, DONGWON | reporter.nih.gov |
| Nicotinamide Adenine Dinucleotide Augmentation to Prevent or Reverse the Progression of Alzheimer's Disease in People with Down Syndrome | NIH | National Institute on Aging | 2025 | $801,359 | September 15, 2025 | August 31, 2028 | BHASIN, SHALENDER | reporter.nih.gov |
| Preventing cognitive impairment in mouse genetic models of Down syndrome by early postnatal suppression of Kir3.2 channel signaling | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2023 to 2024 | $790,000 | September 1, 2020 | August 31, 2026 | KLESCHEVNIKOV, ALEXANDER M | reporter.nih.gov |
| Data Science for Diverse Scholars in Down Syndrome Research (DS3) | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2024 to 2025 | $787,006 | June 1, 2024 | May 31, 2029 | ESPINOSA, JOAQUIN M. | reporter.nih.gov |
| Allelic Expression Imbalance in Trisomy 21 | NIH | National Institute of Neurological Disorders and Stroke | 2025 | $780,000 | June 15, 2025 | May 31, 2027 | THAYER, MATHEW J | reporter.nih.gov |
| Epigenetics of Down Syndrome | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2021 | $751,594 | September 13, 2017 | June 30, 2024 | TYCKO, BENJAMIN | reporter.nih.gov |
| Role of early motor experience in infants with Down syndrome (DS) | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2021 to 2022 | $741,000 | September 1, 2022 | August 31, 2025 | WU, JIANHUA | reporter.nih.gov |
| Neurovascular unit dysfunction in Down syndrome revealed by TBI | NIH | National Institute of Neurological Disorders and Stroke | 2025 | $738,140 | September 7, 2022 | August 31, 2027 | HUANG, MINGXIA | reporter.nih.gov |
| PARTNERS: Program to Advance Research and Transdisciplinary TraiNing in the CarE of PeRsons with Down Syndrome | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2025 | $732,541 | August 7, 2025 | July 31, 2027 | KELLY, ANDREA BRIDGET | reporter.nih.gov |
| Early Developmental Determinants and Pathways in Down syndrome | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2023 to 2025 | $728,854 | September 1, 2023 | August 31, 2027 | WILL, ELIZABETH | reporter.nih.gov |
| Co-Designing and Evaluating Additional Mothers and Babies Program Content for Expectant and New Parents of Children with Down Syndrome | NIH | National Institute of Mental Health | 2025 | $720,000 | September 22, 2025 | September 21, 2028 | RISSER, HEATHER JILL | reporter.nih.gov |
| Use of specific JAK inhibition on inflammatory skin and scalp diseases in Down syndrome | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases | 2024 to 2025 | $708,517 | July 3, 2024 | April 30, 2026 | GUTTMAN, EMMA | reporter.nih.gov |
| Novel Functions of OLIG2 in Regulating Human Interneuron Production in Health and Disease | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2022 | $678,126 | April 1, 2018 | March 31, 2025 | JIANG, PENG | reporter.nih.gov |
| Leveraging E-education to Advance Assent and Decision-Making Involvement in Down Syndrome Administrative Supplement | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2023 to 2024 | $676,460 | August 10, 2023 | July 31, 2025 | KELLY, ANDREA BRIDGET | reporter.nih.gov |
| Developing a Down Syndrome Health Instrument | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2021 to 2024 | $674,577 | April 3, 2020 | March 31, 2025 | SANTORO, STEPHANIE LYNN | reporter.nih.gov |
| Cooking skills to improve long-term weight loss in young adults with intellectual disabilities | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2025 | $674,338 | January 15, 2025 | December 31, 2029 | DONNELLY, JOSEPH E. | reporter.nih.gov |
| A generic and immunological investigation of JAK-STAT in the pathogenesis of Celiac | NIH | National Institute of Diabetes and Digestive and Kidney Diseases | 2022 to 2025 | $661,824 | September 1, 2021 | April 30, 2026 | KONG, XIAO-FEI | reporter.nih.gov |
| Neurodiagnostic, Proteomic, and Metabolomic Investigations into Down Syndrome Regression Disorder | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2025 | $661,575 | August 1, 2025 | May 31, 2030 | SANTORO, JONATHAN DOUGLAS | reporter.nih.gov |
| The role of APP in neurogenesis and AD in Down syndrome | NIH | National Institute on Aging | 2025 | $660,346 | September 15, 2022 | May 31, 2027 | LAZAROV, ORLY | reporter.nih.gov |
| REPOSITORY OF MOUSE MODELS FOR DOWN SYNDROME | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2025 | $649,999 | September 22, 2025 | September 21, 2026 | LUTZ, CATHLEEN | reporter.nih.gov |
| Roles of Periodontal Bacteria-Derived Dihydroceramides in Alzheimer's Disease Exacerbated by Down Syndrome | NIH | National Institute on Aging | 2022 to 2024 | $634,697 | March 15, 2022 | April 30, 2025 | MOVILA, ALEXANDRU | reporter.nih.gov |
| Predictors of Speech Ability in Children with Down Syndrome | NIH | National Institute on Deafness and Other Communication Disorders | 2021 to 2022 | $634,657 | September 1, 2021 | August 31, 2023 | CAMARATA, STEPHEN MARK | reporter.nih.gov |
| Leveraging technology to identify outcome measures for young children with Down syndrome | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2023 | $629,060 | August 1, 2023 | July 31, 2024 | STERLING, AUDRA MARIE | reporter.nih.gov |
| Enhancing treatments for myeloid leukemia associated with Down syndrome | NIH | National Cancer Institute | 2024 to 2025 | $620,749 | August 1, 2024 | July 31, 2028 | TAUB, JEFFREY WARREN | reporter.nih.gov |
| Restoration of proteostasis to address co-occurring conditions in Down Syndrome | NIH | National Institute on Aging | 2025 | $620,401 | September 15, 2022 | August 31, 2027 | NAIDOO, NIRMALA NIRINJINI | reporter.nih.gov |
| JAK Inhibition in Down Syndrome | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases | 2021 | $612,030 | September 25, 2019 | April 30, 2022 | ESPINOSA, JOAQUIN M. | reporter.nih.gov |
| The Role of CSF Dynamics in Infant Brain and Behavioral Development in Down Syndrome and Related Neurodevelopmental Disorders | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2022 to 2025 | $606,819 | September 1, 2022 | August 31, 2027 | GARIC, DEA | reporter.nih.gov |
| Mobile Diagnosis of Congenital Genetic Conditions: A Model for Screening and Surveillance in Low-Resource Settings | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2024 to 2025 | $601,018 | February 1, 2024 | January 31, 2027 | VILAIN, ERIC J. | reporter.nih.gov |
| Infant arousal as a predictor of functional outcomes in Down syndrome (DS) | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2023 to 2025 | $586,448 | August 9, 2023 | July 31, 2026 | GRZADZINSKI, REBECCA LYNN | reporter.nih.gov |
| Systematic functional study of 21st chromosome ortholog overexpression in C. elegans | NIH | Office of the Director, National Institutes of Health | 2022 to 2023 | $573,965 | June 1, 2022 | May 31, 2024 | PIERCE, JONATHAN THOMAS | reporter.nih.gov |
| Self-Supporting Nasopharyngeal Airway (ssNPA) Treating Upper Airway Obstruction in Hypotonia | NIH | National Heart, Lung, and Blood Institute | 2021 | $569,532 | September 1, 2021 | August 31, 2022 | ZOPF, DAVID ADAM | reporter.nih.gov |
| Evaluating ASD Symptomatology in Children with Down Syndrome | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2021 to 2022 | $551,217 | August 1, 2022 | August 31, 2025 | CHANNELL, MARIE MOORE | reporter.nih.gov |
| Executive dysfunction as a treatment target for DS clinical trials: An evaluation of its real-world and neural correlates. | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2021 to 2022 | $540,906 | September 21, 2021 | August 31, 2025 | LEE, NANCY RAITANO | reporter.nih.gov |
| Type I interferon regulates angiogenesis in Down Syndrome Supplement | NIH | National Heart, Lung, and Blood Institute | 2022 to 2023 | $507,399 | September 6, 2022 | January 31, 2025 | AL-ALAM, DENISE | reporter.nih.gov |
| Evaluate the Safety, Tolerability, and Immunogenicity of Adjuvanted Preventive Dual Aβ/tau Vaccine, Duvax in Healthy Volunteers | NIH | National Institute on Aging | 2025 | $499,754 | April 1, 2025 | March 31, 2026 | CRIBBS, DAVID HASTINGS | reporter.nih.gov |
| Commercialization of Selective Dyrk1a Inhibitors for Down Syndrome | NIH | National Institute of Neurological Disorders and Stroke | 2022 | $498,634 | September 15, 2022 | August 31, 2024 | DUNCKLEY, TRAVIS | reporter.nih.gov |
| Effect of APP copy number variants in Alzheimer's disease and and Down Syndrome on Reelin expression and function | NIH | National Institute on Aging | 2023 to 2024 | $498,548 | August 1, 2023 | July 31, 2025 | KOUNNAS, MARIA Z | reporter.nih.gov |
| Uncovering the molecular mechanism of learning and memory with an emphasis on Down Syndrome | NIH | National Institute of General Medical Sciences | 2021 to 2022 | $498,000 | September 15, 2017 | March 31, 2023 | BHATTACHARYYA, MOITRAYEE | reporter.nih.gov |
| Feasibility and outcome measures for infants with Down syndrome: Advancing clinical trial readiness for a harness-based mobility intervention | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2023 | $477,482 | April 4, 2023 | March 31, 2026 | IVERSON, JANA M | reporter.nih.gov |
| The cholinergic integrity in Down syndrome in association with aging, Alzheimer's disease pathology, and cognition | NIH | National Institute on Aging | 2022 | $475,750 | March 1, 2022 | February 28, 2025 | NEWHOUSE, PAUL A. | reporter.nih.gov |
| CellCelector Flex for versatile automated single cell and colony picking | NIH | Office of the Director, National Institutes of Health | 2025 | $466,395 | August 1, 2025 | July 31, 2026 | JOSHI, MOLISHREE UMESH | reporter.nih.gov |
| Iron Metabolism in Ts65Dn mice, a Model of Down syndrome | NIH | National Institute on Aging | 2022 | $465,330 | September 1, 2022 | August 31, 2025 | DERUISSEAU, KEITH C | reporter.nih.gov |
| Determining the neurodevelopmental cell type specific regulatory networks impacted in Down syndrome | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2022 | $464,425 | September 1, 2021 | August 31, 2023 | ALDINGER, KIMBERLY ANNE | reporter.nih.gov |
| Effects of Drumming Lessons on Brain and Behavior in Children with Down Syndrome | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2025 | $463,645 | September 12, 2025 | August 31, 2027 | NEEDHAM, AMY E | reporter.nih.gov |
| Characterizing DNA Methylation Dynamics in Trisomy 21-Associated Hematopoiesis and Leukemia | NIH | National Cancer Institute | 2025 | $462,454 | August 8, 2025 | June 30, 2027 | MA, SAI | reporter.nih.gov |
| Imaging of Mitochondial Complex I function in Down Syndrome | NIH | National Institute on Aging | 2024 to 2025 | $459,250 | August 1, 2024 | May 31, 2027 | PRICE, JULIE C | reporter.nih.gov |
| Establishing the role of Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase 1A trisomy in juvenile plasticity impairment in Down Syndrome | NIH | National Institute of Neurological Disorders and Stroke | 2024 to 2025 | $457,841 | April 15, 2024 | March 31, 2027 | WILLIAM, CHRISTOPHER MAGED | reporter.nih.gov |
| Epigenetic Determinants in Oligodendrocyte Maturation in Down Syndrome | NIH | National Institute of Neurological Disorders and Stroke | 2022 | $453,750 | July 1, 2022 | June 30, 2025 | ZELDICH, ELLA | reporter.nih.gov |
| The contribution of X-chromosome-linked genes to cellular phenotypes and AD-related pathology in Down Syndrome | NIH | National Institute on Aging | 2023 to 2024 | $453,750 | December 1, 2022 | November 30, 2025 | ZELDICH, ELLA | reporter.nih.gov |
| Investigate the utility of APLP1 as an endosomal biomarker for Alzheimer's Disease in Down Syndrome | NIH | National Institute on Aging | 2023 | $452,375 | September 1, 2023 | August 31, 2025 | ALVES SIMOES SPASSOV, SABRINA | reporter.nih.gov |
| CRISPR interference to identify HSA21 genes reducing neurogenesis | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2025 | $451,000 | July 1, 2025 | June 30, 2027 | ROTHERMEL, BEVERLY A | reporter.nih.gov |
| Developing and implementing community based participatory health research with young adults with Down syndrome | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2025 | $446,096 | August 1, 2025 | July 31, 2027 | CHANNELL, MARIE MOORE | reporter.nih.gov |
| The Role of CHAF1B in Maintaining Malignant Leukemia Stem Cells | NIH | National Cancer Institute | 2021 to 2022 | $444,213 | June 1, 2020 | May 31, 2023 | VOLK, ANDREW | reporter.nih.gov |
| ADVANCING CLINICAL PRACTICE AND ESTABLISHING FOUNDATIONAL THEORY FOR AUDITORY FUNCTION IN INDIVIDUALS WITH DOWN SYNDROME | NIH | National Institute on Deafness and Other Communication Disorders | 2022 | $442,807 | May 6, 2022 | April 30, 2025 | PORTER, HEATHER LYNN | reporter.nih.gov |
| Role of congenital heart defects in motor skills and language acquisition of infants with Down syndrome | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2024 to 2025 | $441,846 | June 1, 2024 | May 31, 2027 | WU, JIANHUA | reporter.nih.gov |
| Telehealth-delivered outcome measures for Spanish- and English-speaking people with Down syndrome | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2023 | $441,250 | September 20, 2023 | August 31, 2025 | ABBEDUTO, LEONARD J. | reporter.nih.gov |
| Improving Body Composition Assessment and Physical Activity Monitoring in Adults with Down Syndrome using Mobile Technology | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2024 to 2025 | $438,362 | August 1, 2024 | July 31, 2026 | NICKERSON, BRETT STEPHEN | reporter.nih.gov |
| Development of an Ecological Momentary Assessment Outcome Measure for Down Syndrome Clinical Trials | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2021 | $431,750 | August 15, 2021 | July 31, 2024 | HESSL, DAVID R | reporter.nih.gov |
| Leveraging Mobile and Wearable Technology to Facilitate Healthy Behaviors in Children and Adolescents with Down Syndrome. | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2025 | $431,750 | August 19, 2025 | July 31, 2027 | DALLMAN, AARON RAY | reporter.nih.gov |
| Characterizing Language and Motor Development of Racially/Ethnically Diverse Infants and Toddlers with Down Syndrome | NIH | National Institute on Deafness and Other Communication Disorders | 2024 to 2025 | $430,426 | June 1, 2024 | May 31, 2027 | VANEGAS, SANDRA | reporter.nih.gov |
| Use of a digital memory prosthetic to support autobiographical memory in down syndrome | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2024 to 2025 | $430,375 | August 15, 2024 | July 31, 2027 | FORD, JACLYN HENNESSEY | reporter.nih.gov |
| Defining the association between trisomy 21 and placentation defects | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2025 | $430,375 | July 17, 2025 | June 30, 2027 | BRUMBAUGH, JUSTIN | reporter.nih.gov |
| Dissecting SARS-CoV-2 infection in Down syndrome with congenital heart defects using patient-specific iPSCs | NIH | National Heart, Lung, and Blood Institute | 2022 to 2023 | $429,000 | September 6, 2022 | July 31, 2025 | ZHAO, MINGTAO | reporter.nih.gov |
| A new approach to understanding cognitive disabilities in Down syndrome | NIH | National Institute of Neurological Disorders and Stroke | 2023 | $429,000 | September 19, 2023 | August 31, 2025 | OH, WON CHAN | reporter.nih.gov |
| Human Embryonic Stem Cell Models for Studying Mechanisms Underlying Changes In Inhibitory Synapses in Down Syndrome | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2024 | $429,000 | September 11, 2024 | August 31, 2026 | SMITH, GARY DANIEL | reporter.nih.gov |
| Defining molecular and gene-regulatory dysregulation in Down Syndrome tissues and models | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2022 to 2023 | $428,989 | March 10, 2022 | February 28, 2025 | DE LA TORRE-UBIETA, LUIS | reporter.nih.gov |
| Abnormal HIF signaling in Down syndrome-related pulmonary hypertension | NIH | National Heart, Lung, and Blood Institute | 2022 to 2023 | $427,625 | September 6, 2022 | July 31, 2024 | GALAMBOS, CSABA | reporter.nih.gov |
| Gastrointestinal Dysfunction in Down Syndrome | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2024 to 2025 | $426,938 | July 3, 2024 | June 30, 2026 | AKBARALI, HAMID I | reporter.nih.gov |
| Development of a Novel mHealth Platform to Track Health Behaviors of Young Children with Down Syndrome | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2023 | $422,132 | February 10, 2023 | January 31, 2026 | CALDWELL, ANGELA RENEE | reporter.nih.gov |
| DEtermining Capacity and Informing Down syndrome Assent Strategies (DECIDAS) | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2022 to 2023 | $422,125 | September 8, 2022 | August 31, 2025 | COMBS, DANIEL | reporter.nih.gov |
| Finding the contribution of the autonomic nervous system during perioperative events in children with Down Syndrome | NIH | National Heart, Lung, and Blood Institute | 2021 | $421,134 | September 17, 2021 | June 30, 2024 | SINTON, JAMIE W | reporter.nih.gov |
| Role of IFNs and IFNGR in susceptibility to bacteria in Down syndrome | NIH | National Institute of Allergy and Infectious Diseases | 2021 to 2022 | $421,086 | February 22, 2021 | January 31, 2023 | LENZ, LAUREL L | reporter.nih.gov |
| DYRK1A interaction network in development and disease | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2022 | $413,529 | August 1, 2022 | July 31, 2025 | LITOVCHICK, LARISA | reporter.nih.gov |
| Mobile Diagnosis of Congenital Genetic Conditions: A Model for Screening and Surveillance in Low-Resource Settings | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2021 | $409,475 | September 1, 2021 | January 31, 2024 | LINGURARU, MARIUS GEORGE | reporter.nih.gov |
| Hyperexcitability in Alzheimer's Disease | NIH | National Institute on Aging | 2021 | $404,250 | April 1, 2017 | September 30, 2023 | SCHARFMAN, HELEN E | reporter.nih.gov |
| The paradox of myeloid leukemia of Down syndrome | NIH | National Cancer Institute | 2023 | $395,973 | June 9, 2023 | May 31, 2025 | TAUB, JEFFREY WARREN | reporter.nih.gov |
| Administrative Supplement: A Profile of Spatial Abilities in People with Down Syndrome and Their Correlations with Everyday Behavior | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2021 to 2022 | $394,269 | September 1, 2022 | April 30, 2024 | YANG, YINGYING | reporter.nih.gov |
| Sleep Disruption and Alzheimer's Disease Pathology | NIH | National Institute on Aging | 2022 | $390,259 | August 1, 2019 | June 30, 2024 | OPP, MARK R | reporter.nih.gov |
| Mechanisms of leukemogenesis in Down syndrome | NIH | National Cancer Institute | 2021 | $383,681 | February 11, 2021 | September 21, 2021 | CRISPINO, JOHN D | reporter.nih.gov |
| Toward a neuroscientific understanding of the interaction between Down syndrome and Alzheimer's disease pathology | NIH | National Institute on Aging | 2023 to 2025 | $377,541 | September 1, 2023 | May 31, 2028 | BRUNO, JENNIFER L | reporter.nih.gov |
| Assessment of Physical Activity for Alzheimer's Disease Research in Down Syndrome | NIH | National Institute on Aging | 2023 to 2025 | $375,308 | September 1, 2023 | May 31, 2028 | HELSEL, BRIAN | reporter.nih.gov |
| Advancing cross-national research on aging and cognitive function: English/Spanish courses with the Mexican Health and Aging Study and HRS/HCAP global partner studies | NIH | National Institute on Aging | 2025 | $372,904 | September 20, 2025 | May 31, 2030 | WONG, REBECA | reporter.nih.gov |
| CArdiometabolic riSk and Comorbidities in Adults with Down syndrome- Electronic Health Record Examination (CASCADE) | NIH | National Heart, Lung, and Blood Institute | 2025 | $370,096 | September 15, 2025 | August 31, 2027 | KELLY, ANDREA BRIDGET | reporter.nih.gov |
| Home sleep apnea testing compared to in-lab polysomnography for the evaluation of obstructive sleep apnea in children | NIH | National Heart, Lung, and Blood Institute | 2022 | $360,115 | August 1, 2022 | July 31, 2023 | CIELO, CHRISTOPHER MICHAEL | reporter.nih.gov |
| Elucidating USP16 function and probing its DUB activity in Down syndrome leukemia | NIH | National Cancer Institute | 2021 to 2024 | $350,888 | February 1, 2021 | January 31, 2025 | NIEDERKORN, MADELINE | reporter.nih.gov |
| Heart and vascular responses across the lifespan in Ts65Dn mice, a model of Down syndrome | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2021 | $350,712 | September 1, 2021 | August 31, 2022 | DERUISSEAU, LARA ROBERTS | reporter.nih.gov |
| Dissecting the role of germline genetic variation and viral exposures as determinants of hematological disease predisposition | NIH | National Cancer Institute | 2024 | $336,000 | July 1, 2024 | June 30, 2026 | TRICHE, TIMOTHY J. | reporter.nih.gov |
| Down Syndrome Memantine Follow-up Study: EEG Data Analysis and Data Sharing with the Research Community | NIH | National Institute on Aging | 2024 | $322,000 | September 20, 2024 | August 31, 2026 | COSTA, ALBERTO C S | reporter.nih.gov |
| Type I Interferon Dysregulation in Down Syndrome | NIH | National Institute of Allergy and Infectious Diseases | 2021 | $320,158 | September 16, 2019 | March 31, 2024 | BOGUNOVIC, DUSAN | reporter.nih.gov |
| Differentiation and Integration of Trisomy 21 iPSCs in an Animal Model | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2021 | $319,259 | August 1, 2017 | April 30, 2023 | TIAN, LIN | reporter.nih.gov |
| Enriching medical phenotypes and environmental traits in the large DS360 Down syndrome cohort | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2022 | $313,000 | May 1, 2022 | April 30, 2025 | ROSSER, TRACIE C | reporter.nih.gov |
| Curation and analysis of publicly available, molecular profiles from people with Down Syndrome | NIH | National Heart, Lung, and Blood Institute | 2024 to 2025 | $310,521 | June 1, 2024 | May 31, 2027 | PICCOLO, STEPHEN | reporter.nih.gov |
| Down syndrome and Psoriasis: An Investigation of Cardiometabolic Risk | NIH | National Heart, Lung, and Blood Institute | 2024 to 2025 | $310,000 | May 1, 2024 | April 30, 2026 | RORK, JILLIAN | reporter.nih.gov |
| Mechanisms for cell signaling in the control of cardiomyogenesis | NIH | National Heart, Lung, and Blood Institute | 2022 | $309,589 | August 1, 2016 | August 15, 2023 | SONG, KUNHUA | reporter.nih.gov |
| Predictors of mortality and of healthy survival in a large community-based prospective cohort of aging adults with Down syndrome | NIH | National Institute on Aging | 2022 to 2023 | $299,000 | September 15, 2022 | August 31, 2025 | HILGENKAMP, THESSA | reporter.nih.gov |
| Early Developmental Determinants and Pathways in Down syndrome | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2021 to 2022 | $291,072 | September 1, 2021 | August 31, 2023 | WILL, ELIZABETH | reporter.nih.gov |
| Depression, Stress, and Down Syndrome. A Multimethod Approach to Assessment | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2021 to 2022 | $288,988 | April 10, 2018 | March 31, 2024 | BROWN, RUTH C | reporter.nih.gov |
| Evaluating the role of high-dose influenza vaccine in people with Down syndrome under age 65 | NIH | National Institute of Allergy and Infectious Diseases | 2025 | $286,793 | September 24, 2025 | August 31, 2026 | SPEAKE, CATE | reporter.nih.gov |
| Delineating a role for histone modifications in Down syndrome using human cellular models | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2022 | $285,042 | August 1, 2022 | March 31, 2025 | BARRETT, LINDY ELISE | reporter.nih.gov |
| Gene Expression Networks for Human Cardiac Differentiation in Down Syndrome | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2021 | $277,548 | September 1, 2020 | August 31, 2023 | MOSKOWITZ, IVAN PAUL | reporter.nih.gov |
| Vitamin E Trial in Persons with Down Syndrome: Sharing Data with the Research Community | NIH | National Institute on Aging | 2023 | $257,000 | June 15, 2023 | May 31, 2025 | ANDREWS, HOWARD F. | reporter.nih.gov |
| Intraindividual cognitive variability in aging adults with Down syndrome: associations with Alzheimer's disease plasma biomarkers, neuropathology and clinical dementia | NIH | National Institute on Aging | 2023 to 2024 | $256,140 | August 15, 2023 | July 31, 2025 | FONSECA, LUCIANA | reporter.nih.gov |
| Astrocyte-secreted proteins as modulators of neurodegeneration in Down Syndrome and Alzheimers Disease | NIH | National Institute on Aging | 2023 to 2024 | $248,400 | June 1, 2023 | May 31, 2025 | BRANDEBURA, ASHLEY N | reporter.nih.gov |
| Genetic determinants of lymphocyte traits and risk of acute lymphoblastic leukemia in children with Down syndrome | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2022 to 2023 | $247,500 | September 15, 2022 | August 31, 2025 | DE SMITH, ADAM | reporter.nih.gov |
| Home Sleep Apnea Testing and Neurocognitive Testing for Obstructive Sleep Apnea in Young Adults with Down Syndrome | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2021 | $247,445 | September 1, 2021 | August 31, 2023 | KELLY, ANDREA BRIDGET | reporter.nih.gov |
| Intraindividual cognitive variability in aging adults with Down syndrome: associations with Alzheimer's disease plasma biomarkers, neuropathology and clinical dementia | NIH | National Institute on Aging | 2025 | $247,244 | August 15, 2023 | May 31, 2028 | FONSECA, LUCIANA | reporter.nih.gov |
| Astrocyte-secreted proteins as modulators of neurodegeneration in Down Syndrome and Alzheimers Disease | NIH | National Institute on Aging | 2025 | $244,020 | June 1, 2023 | February 29, 2028 | BRANDEBURA, ASHLEY N | reporter.nih.gov |
| Central & Peripheral blood flow regulation in individuals with Down syndrome | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2021 | $243,761 | September 20, 2019 | August 31, 2024 | HILGENKAMP, THESSA | reporter.nih.gov |
| TS21 Effects on Senescence/SASP in neurons, glia and cell-specific exosomes, and spread of phenotype in vitro | NIH | National Institute on Aging | 2023 | $235,375 | June 15, 2023 | June 16, 2023 | GYLYS, KAREN H | reporter.nih.gov |
| Single cell analysis of dysregulated inducible DNA amplifications of immune response genes in Down syndrome | NIH | National Institute of Allergy and Infectious Diseases | 2025 | $234,000 | July 16, 2025 | June 30, 2027 | SULLIVAN, KELLY D. | reporter.nih.gov |
| Remote assessments for Alzheimer’s disease cognitive decline in adults with Down syndrome | NIH | National Institute on Aging | 2024 to 2025 | $212,760 | June 1, 2024 | May 31, 2026 | SCHWORER, EMILY KATHERINE | reporter.nih.gov |
| TS21 Effects on Senescence/SASP in neurons, glia and cell-specific exosomes, and spread of phenotype in vitro | NIH | National Institute on Aging | 2024 | $201,875 | June 15, 2023 | February 28, 2026 | GYLYS, KAREN H | reporter.nih.gov |
| Heterogeneous genetics effects and mediation in Alzheimer's disease | NIH | National Institute on Aging | 2025 | $195,041 | December 1, 2024 | November 30, 2026 | WANG, JIEBIAO | reporter.nih.gov |
| Studying Epigenetic Dysregulation in Down Syndrome Using Fluorescent Reporter Cell Lines | NIH | National Institute of Neurological Disorders and Stroke | 2022 to 2023 | $165,000 | March 1, 2022 | February 28, 2025 | ZELDICH, ELLA | reporter.nih.gov |
| Elevated mitochondrial fusion and function in Down syndrome - Revision - 2 | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2022 | $164,899 | September 1, 2022 | June 30, 2024 | ROTHERMEL, BEVERLY A | reporter.nih.gov |
| Evaluating Assessment and Medication Treatment of ADHD in Children with Down Syndrome | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2021 | $164,639 | September 30, 2019 | September 14, 2022 | ESBENSEN, ANNA J. | reporter.nih.gov |
| Improving Health Care Communication and Engagement for Adults with Down syndrome | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2025 | $163,813 | September 3, 2025 | August 31, 2030 | SANDERS, JESSICA SOLOMON | reporter.nih.gov |
| Development of aging-sensitive spoken language measures in children, adolescents, and young adults with Down Syndrome | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2023 to 2024 | $160,312 | April 1, 2023 | March 31, 2026 | THURMAN, ANGELA JOHN | reporter.nih.gov |
| Maternal acetaminophen use and childhood cancer | NIH | National Cancer Institute | 2022 to 2023 | $159,119 | August 1, 2022 | October 31, 2024 | HECK, JULIA | reporter.nih.gov |
| Dysregulation of transcription factors and chromatin architecture in Trisomy 21 hematopoietic disorders | NIH | National Heart, Lung, and Blood Institute | 2025 | $158,976 | September 1, 2025 | June 30, 2030 | TAKASAKI, KAORU | reporter.nih.gov |
| Establishing foundational tools and datasets for investigation of NSD1 gene function in neural development | NIH | National Center for Advancing Translational Sciences | 2023 | $158,000 | August 15, 2023 | August 14, 2025 | BARRETT, LINDY ELISE | reporter.nih.gov |
| Regulation of the DYRK1A kinase by the Down Syndrome Cell Adhesion Molecule DSCAM | NIH | National Institute of Neurological Disorders and Stroke | 2022 | $150,000 | September 8, 2022 | February 15, 2023 | FUERST, PETER GERARD | reporter.nih.gov |
| Modeling Basal Forebrain Cholinergic Neurons in Down syndrome | NIH | National Institute on Aging | 2021 to 2022 | $143,697 | June 15, 2021 | February 28, 2023 | MARTINEZ, JOSE LUIS | reporter.nih.gov |
| Investigating Trisomy 21 Impact on Human Neural Cell Development and Function Using "Trisomy Silencing" in vitro | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2021 to 2024 | $138,280 | August 19, 2021 | August 18, 2025 | LARSEN, ERIC CHRISTOPHER | reporter.nih.gov |
| The Economics of Special Education for Individuals with Developmental Disabilities including Down Syndrome | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2025 | $131,166 | August 1, 2025 | July 31, 2030 | SABETY, ADRIENNE | reporter.nih.gov |
| Medications for Obstructive Sleep Apnea to Improve Cognition in Children with Down Syndrome (MOSAIC DS) | NIH | National Heart, Lung, and Blood Institute | 2021 | $130,148 | September 15, 2019 | August 31, 2022 | COMBS, DANIEL | reporter.nih.gov |
| Investigating injury response and bone regeneration in Down syndrome mouse models | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2022 to 2024 | $116,064 | September 1, 2022 | August 31, 2025 | SHERMAN, KIRBY M. | reporter.nih.gov |
| APP as a mediator of amyloid beta effects on CaMKII synaptic functions | NIH | National Institute on Aging | 2023 to 2025 | $114,586 | August 3, 2023 | August 2, 2026 | LARSEN, MATTHEW E | reporter.nih.gov |
| Role of astrocyte-secreted pleiotrophin in dendritic spine phenotypes in Down Syndrome | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2022 | $101,291 | June 1, 2021 | November 30, 2022 | BRANDEBURA, ASHLEY N | reporter.nih.gov |
| Rare variants associated with AVSD in Down Syndrome | NIH | National Heart, Lung, and Blood Institute | 2024 to 2025 | $98,512 | September 13, 2024 | September 12, 2027 | FELDMAN, ELIZABETH | reporter.nih.gov |
| Synergistic contributions of cerebrovascular disease and neuroinflammation to Alzheimer's disease in adults with Down syndrome | NIH | National Institute on Aging | 2024 to 2025 | $98,512 | September 1, 2024 | August 31, 2027 | EDWARDS, NATALIE CATHERINE | reporter.nih.gov |
| Systematic Analysis of 21st Chromosome Ortholog Overexpression in C. elegans | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2021 to 2022 | $80,313 | September 1, 2021 | August 31, 2023 | SANCHEZ, SOPHIA M | reporter.nih.gov |
| Investigating the Role of Extracellular Matrix in Down Syndrome Associated Cardiac Phenotypes. | NIH | National Heart, Lung, and Blood Institute | 2025 | $78,520 | February 1, 2025 | January 31, 2028 | BORDEN, LEAH K | reporter.nih.gov |
| Moving Forward: Early Predictors of Crawling and Walking in Infants with DS | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2024 | $78,328 | January 1, 2025 | December 31, 2027 | COLLIMORE, ASHLEY | reporter.nih.gov |
| Body composition, physical activity, and cognitive function in Down syndrome | NIH | National Institute on Aging | 2025 | $77,752 | September 8, 2025 | September 7, 2027 | CLINA, JULIANNE | reporter.nih.gov |
| Defining the link between trisomy 21 and placentation defects | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2024 | $76,408 | December 1, 2024 | November 30, 2027 | LOGSDON, DEIRDRE | reporter.nih.gov |
| Investigating the susceptibility of basal forebrain cholinergic neurons in individuals with Down syndrome | NIH | National Institute on Aging | 2024 to 2025 | $74,210 | July 1, 2024 | June 30, 2026 | WEST, NICOLE | reporter.nih.gov |
| Role of endosulfine-alpha expression and phosphorylation in Parkinson's Disease | NIH | National Institute of Neurological Disorders and Stroke | 2021 | $73,496 | August 15, 2021 | April 30, 2022 | ROCHET, JEAN-CHRISTOPHE | reporter.nih.gov |
| Weight, inflammation, and Alzheimer's disease in Down syndrome | NIH | National Institute on Aging | 2024 to 2025 | $72,793 | May 1, 2024 | April 30, 2027 | FLEMING, VICTORIA | reporter.nih.gov |
| Individual Predoctoral Fellowship | NIH | National Institute on Aging | 2023 to 2025 | $72,482 | February 2, 2024 | February 1, 2027 | DOOLING, BREANNA | reporter.nih.gov |
| Identifying targets that lower APP as a therapeutic strategy for Alzheimer's disease | NIH | National Institute on Aging | 2021 | $68,562 | September 1, 2020 | August 31, 2022 | JOHNSON, JENNIFER LEIGH | reporter.nih.gov |
| T21RS Meeting June 2024 Rome, Italy | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2024 | $57,500 | March 15, 2024 | March 14, 2025 | HEAD, ELIZABETH | reporter.nih.gov |
| Early Features of Autism Risk in Down Syndrome | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2021 | $49,658 | January 1, 2019 | August 31, 2021 | WILL, ELIZABETH | reporter.nih.gov |
| Investigating the impact of chromosome 21 dosage on the placenta secretome and neurodevelopment | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2025 | $49,538 | March 26, 2025 | March 25, 2027 | SPIEGELBERG, BAILEY | reporter.nih.gov |
| The Contribution of Microglia to Neurodevelopmental Dysfunction in Down Syndrome | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2025 | $42,596 | August 4, 2025 | August 3, 2029 | CURTIN, GENEVIEVE TAPLITZ | reporter.nih.gov |
| Investigating the mechanisms of reduced neuron generation in Down Syndrome | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2025 | $40,502 | September 1, 2025 | October 31, 2028 | PICIW, JENNIFER GRACE | reporter.nih.gov |
| Understanding and supporting cancer survivorship needs of children with Down syndrome in remission from leukemia and their families | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2025 | $39,271 | August 18, 2025 | August 17, 2027 | KABAKOV, SABRINA A | reporter.nih.gov |
| The Consequences of Aneuploidy | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2024 | $39,000 | September 1, 2024 | August 31, 2025 | GODEK, KRISTINA M | reporter.nih.gov |
| Molecular Mechanisms of Defective Oligodendrocyte Differentiation in Down Syndrome | NIH | National Institute of Neurological Disorders and Stroke | 2021 | $37,634 | September 28, 2020 | May 31, 2022 | KLEIN, JENNY ADELE | reporter.nih.gov |
| T21RS Meeting June 2022 Long Beach, California | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2022 | $37,500 | April 5, 2022 | March 31, 2023 | HEAD, ELIZABETH | reporter.nih.gov |
| Deciphering Central Nervous System Autoimmunity in Down Syndrome | NIH | National Institute of Allergy and Infectious Diseases | 2025 | $37,336 | July 29, 2025 | July 28, 2028 | LAU, CRISTINA I | reporter.nih.gov |
| 2023 International Mosaic Down Syndrome Association Community-Empowered Research and Retreat Weekend: Increasing Partnerships, Cohorts, and Diversity for Research Related to Down Syndrome | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2023 | $37,100 | April 1, 2023 | March 31, 2024 | JACKSON-COOK, COLLEEN K | reporter.nih.gov |
| FASEB SRC: The Consequences of Aneuploidy: Honoring the Contributions of Angelika Amon | NIH | National Cancer Institute | 2022 | $35,000 | September 13, 2022 | August 31, 2023 | SHELTZER, JASON | reporter.nih.gov |
| Investigation and deployment of novel Bayesian inference algorithms in CAVATICA for identifying genomic variants underlying congenital heart defects in Down syndrome individuals | NIH | National Heart, Lung, and Blood Institute | 2023 | $24,517 | May 1, 2023 | August 31, 2023 | LIU, JINLING | reporter.nih.gov |
| Cerebellar hypoplasia and chromosome elimination in mouse models of Down syndrome | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2021 | $23,411 | July 17, 2019 | September 30, 2021 | MOYER, ANNA JOYCE | reporter.nih.gov |
| Function and dysfunction of REST in neurodegeneration | NIH | National Institute of Neurological Disorders and Stroke | 2021 | $13,142 | May 1, 2019 | June 18, 2021 | FERNANDEZ, MARTY | reporter.nih.gov |
| Capturing and characterizing variability of cognition and behavior in Down syndrome | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2021 | $1 | September 15, 2021 | September 16, 2021 | HUNTER, JESSICA EZZELL | reporter.nih.gov |
| Investigating the Mechanism of Optic Nerve disorders associated with Down Syndrome | NIH | National Eye Institute | 2023 | $1 | August 1, 2023 | December 9, 2023 | MUKHERJEE, KONARK | reporter.nih.gov |
Organizations
Funding by fiscal year
| Fiscal year | NIH awards | NIH amount | NSF awards | NSF amount |
|---|---|---|---|---|
| 2025 | 146 | $129,643,691 | 0 | $0 |
| 2024 | 144 | $136,935,431 | 0 | $0 |
| 2023 | 131 | $137,907,114 | 0 | $0 |
| 2022 | 131 | $118,167,073 | 0 | $0 |
| 2021 | 109 | $101,373,725 | 0 | $0 |
Open federal funding opportunities
From Grants.gov: notices that funded awards in this table, and open notices on the same agency and assistance listing.
Updated November 4, 2026. Read from NIH RePORTER ExPORTER and NSF Award Search. Published by NIH and NSF as U.S. government data. NIH awards are fiscal years 2021 to 2025 (NIH files published to 2026-07-09); NSF awards are fiscal years 2022 to 2026 (NSF files published to 2026-11-04). NIH amounts are the total cost of each fiscal year in the window; NSF amounts are the funds obligated in the window. Organizations are matched on the UEI. Open opportunities come from Grants.gov and match on agency and assistance listing number, and on the notice number NIH prints on an award. Free to reuse with credit to SpecStream under CC BY 4.0. Spot a wrong value? Write to [email protected] with the link to this page.