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Data / Research funding / Congenital Heart Disease

Congenital Heart Disease: 583 NIH awards ($676.3M) to 149 organizations

583 NIH awards ($676.3M) in the NIH spending category Congenital Heart Disease, to 149 organizations, read 2026-11-03. NIH fiscal years 2021 to 2025.

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Awards

The 500 largest of 583 awards in the window.

AwardAgencyInstitute or divisionFiscal yearAmount in windowStartEndPrincipal investigatorSource
Ola HAWAIINIHNational Institute on Minority Health and Health Disparities2021 to 2025$25,522,287September 23, 1997May 31, 2027HEDGES, JERRIS ROBERTreporter.nih.gov
Administrative Coordinating Center: Bench to Bassinet ProgramNIHNational Heart, Lung, and Blood Institute2021 to 2024$21,378,391January 1, 2016December 31, 2025OLLBERDING, NICHOLAS Jreporter.nih.gov
Cavopulmonary Assist to Reverse the FontanNIHNational Heart, Lung, and Blood Institute2021 to 2023$6,543,627September 14, 2020August 31, 2025RODEFELD, MARK Dreporter.nih.gov
PET/MRI imaging of mitral valve prolapseNIHNational Heart, Lung, and Blood Institute2023 to 2025$6,137,934August 25, 2023June 30, 2028TRIVIERI, MARIA GIOVANNAreporter.nih.gov
Cardiovascular Development Data Resource Center (CDDRC)NIHNational Heart, Lung, and Blood Institute2021 to 2024$5,768,733August 20, 2020July 31, 2025YOST, H. JOSEPHreporter.nih.gov
Decrypting Variants of Uncertain Significance in Long-QT SyndromeNIHNational Heart, Lung, and Blood Institute2021 to 2024$5,148,685August 1, 2014July 31, 2026GEORGE, ALFRED L.reporter.nih.gov
Toward efficient performance for deep learning on medical imagingNIHNational Heart, Lung, and Blood Institute2021 to 2025$4,624,228April 1, 2020March 31, 2030ARNAOUT, RIMAreporter.nih.gov
Evaluating Assessment and Medication Treatment of ADHD in Children with Down SyndromeNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2022 to 2024$4,182,561May 1, 2024August 31, 2025ESBENSEN, ANNA J.reporter.nih.gov
Probing Phenotype-Genotype Relations After Whole Genome Sequencing in Patients with Atrial FibrillationNIHNational Heart, Lung, and Blood Institute2021 to 2025$4,058,145September 1, 2021July 31, 2026SHOEMAKER, MOORE BENJAMINreporter.nih.gov
Pulmonary Valved Graft with Regeneration Potential for Pediatric PatientsNIHNational Heart, Lung, and Blood Institute2021 to 2025$3,958,584May 24, 2019February 28, 2027HOUDE, AJAYreporter.nih.gov
Exploring the relationship between advanced multimodal brain MRI phenotypes, genes and cognitive outcome in adults with CHDNIHNational Heart, Lung, and Blood Institute2021 to 2025$3,938,586March 15, 2021February 28, 2027GRANT, PATRICIA ELLENreporter.nih.gov
Targeting Mitochondria in Single Ventricle Heart DiseaseNIHNational Heart, Lung, and Blood Institute2021 to 2025$3,873,722March 15, 2021January 31, 2026MIYAMOTO, SHELLEY DEANNEreporter.nih.gov
Prospective sudden cardiac death risk stratification using CMR and echocardiography machine learning in mitral valve prolapseNIHNational Heart, Lung, and Blood Institute2021 to 2024$3,864,384May 26, 2020April 30, 2026DELLING, FRANCESCA Nreporter.nih.gov
Optical Tools to Assess the Role of Cardiac Function in the Development of Congenital Heart DefectsNIHNational Heart, Lung, and Blood Institute2021 to 2025$3,824,765July 1, 2015February 28, 2027JENKINS, MICHAEL W.reporter.nih.gov
Cilia in Heart Development and DiseaseNIHNational Heart, Lung, and Blood Institute2021 to 2025$3,728,670February 15, 2019January 31, 2026BRUECKNER, MARTINAreporter.nih.gov
Cardiogenesis: Molecular MechanismsNIHNational Heart, Lung, and Blood Institute2021 to 2025$3,717,603January 10, 1997May 31, 2028SRIVASTAVA, DEEPAKreporter.nih.gov
Mechanism of Myocardial Fibrosis Induced by Mitral Valve ProlapseNIHNational Heart, Lung, and Blood Institute2024 to 2025$3,657,264September 5, 2024July 31, 2028LEVINE, ROBERT Areporter.nih.gov
Improving Tissue Engineered Vascular Graft Performance via Computational ModelingNIHNational Heart, Lung, and Blood Institute2021 to 2025$3,638,571January 1, 2018March 31, 2027BREUER, CHRISTOPHER KANEreporter.nih.gov
1/2 Allogeneic Human Mesenchymal Stem Cell (MSC) Injection in Patients with Hypoplastic Left Heart Syndrome: A Phase IIb Clinical TrialNIHNational Heart, Lung, and Blood Institute2021 to 2024$3,521,212September 15, 2020August 31, 2025BERGER, STUARTreporter.nih.gov
Genetic Control of Cardiac Development: Congenital Heart Disease Gene Discovery in DrosophilaNIHNational Heart, Lung, and Blood Institute2021 to 2024$3,338,929August 1, 1995June 30, 2025BODMER, ROLFreporter.nih.gov
Development of a Polymeric Percutaneous Pulmonary Valve for Use in Young ChildrenNIHNational Heart, Lung, and Blood Institute2021 to 2025$3,231,750August 15, 2016February 28, 2029HARRINGTON, DANIEL Areporter.nih.gov
Exercise Intolerance in Non Obstructive Hypertrophic CardiomyopathyNIHNational Heart, Lung, and Blood Institute2022 to 2025$3,213,836May 1, 2022February 28, 2027ABRAHAM, THEODORE Preporter.nih.gov
Microstructural Response of the Myocardium to Mechanical LoadNIHNational Heart, Lung, and Blood Institute2021 to 2024$3,205,295July 1, 2021May 31, 2026SOSNOVIK, DAVID Ereporter.nih.gov
DUCTUS ARTERIOSUS STENT TO IMPROVE CONGENITAL HEART DEFECT MORTALITYNIHNational Heart, Lung, and Blood Institute2022 to 2025$3,158,101August 6, 2021December 31, 2027TANG, BEVERLYreporter.nih.gov
Genetic modifiers of congenital heart disease in 22q11.2 deletion syndromeNIHNational Heart, Lung, and Blood Institute2022 to 2025$3,070,980February 1, 2022January 31, 2027MORROW, BERNICE Ereporter.nih.gov
Genetic determinants of 4D genome folding in human cardiac developmentNIHNational Heart, Lung, and Blood Institute2021 to 2024$3,069,960September 21, 2020August 31, 2025BRUNEAU, BENOIT GAETANreporter.nih.gov
Mechanobiology of Cardiac Outflow Tract MorphogenesisNIHNational Heart, Lung, and Blood Institute2022 to 2025$3,068,575March 15, 2022February 28, 2027BUTCHER, JONATHAN TALBOTreporter.nih.gov
Metabolic profiling and comprehensive metabolic pathway mapping: a systems biology approach to cardiovascular failure and organ injury following infant congenital heart disease surgeryNIHNational Heart, Lung, and Blood Institute2021 to 2025$3,061,754May 1, 2021April 30, 2027DAVIDSON, JESSEreporter.nih.gov
Gene-by-environment interactions that affect exposure-mediated congenital heart diseaseNIHNational Institute of Environmental Health Sciences2021 to 2025$3,058,037September 10, 2021June 30, 2027WHITEHEAD, JOHN ANDREWreporter.nih.gov
Early cardiac progenitorsNIHNational Heart, Lung, and Blood Institute2021 to 2025$3,025,531July 1, 2013July 31, 2029BRUNEAU, BENOIT GAETANreporter.nih.gov
Heightened hypoxia and DNA methylation in heart defects of diabetic embryopathyNIHNational Heart, Lung, and Blood Institute2022 to 2025$3,020,733September 15, 2022July 31, 2027YANG, PEIXINreporter.nih.gov
Cell-Type Specific Mechanisms of Mitral Valve ProlapseNIHNational Heart, Lung, and Blood Institute2025$3,008,247September 1, 2025August 31, 2029CHI, NEIL Creporter.nih.gov
In vivo Characterization of Regulatory Variant Pathogenicity in Congenital Heart DiseaseNIHNational Heart, Lung, and Blood Institute2022 to 2025$2,998,900January 1, 2022December 31, 2026VISEL, AXELreporter.nih.gov
Development of an oxygen delivery biotherapeutic for the preservation of myocardial function during pediatric cardiopulmonary bypassNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2023 to 2025$2,986,551August 1, 2017August 31, 2027WINGER, JONATHAN Areporter.nih.gov
Sudden Death Risk Assessment and Mechanistic Insights in Arrhythmic Mitral Valve Prolapse Using Cardiac MRI and Circulating Proteomic BiomarkersNIHNational Heart, Lung, and Blood Institute2024 to 2025$2,960,139September 5, 2024June 30, 2029SHAH, DIPAN J.reporter.nih.gov
Polyunsaturated fatty acids as anti-arrhythmic agents.NIHNational Heart, Lung, and Blood Institute2021 to 2024$2,942,029September 15, 2016March 31, 2026BARRO-SORIA, RENEreporter.nih.gov
Neurometabolic Outcomes of Different Cardiopulmonary Bypass StrategiesNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,911,403February 15, 2021January 31, 2026HANLEY, FRANKreporter.nih.gov
Pharmacologic Contributors to Patent Ductus ArteriosusNIHNational Heart, Lung, and Blood Institute2022 to 2025$2,898,557July 1, 2022June 30, 2027REESE, JOHN JEFFREYreporter.nih.gov
Role of Cyclohexanone Toxicity in Mediating Congenital Cardiac Surgery OutcomesNIHNational Heart, Lung, and Blood Institute2022 to 2025$2,885,985June 1, 2022May 31, 2027JANTZIE, LAUREN LEIGH COONEYreporter.nih.gov
Pathophysiologic Mechanism for Arrhythmias and Impaired Aerobic Capacity in Tetralogy of FallotNIHNational Heart, Lung, and Blood Institute2021 to 2025$2,871,936August 1, 2021July 31, 2027EGBE, ALEXANDERreporter.nih.gov
A protein traffic control system that regulates left-right patterning and heart developmentNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,868,559September 1, 2021August 31, 2025ROHATGI, RAJATreporter.nih.gov
Computer Modeling of the Tricuspid Valve in Hypoplastic Left Heart SyndromeNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,867,475July 20, 2020June 30, 2026JOLLEY, MATTHEWreporter.nih.gov
Elucidating the Molecular Mechanisms Underlying LYST-mediated Tissue Engineered Vascular Graft StenosisNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,861,908April 1, 2021March 31, 2026BREUER, CHRISTOPHER KANEreporter.nih.gov
Cilia and Valvular Heart DiseaseNIHNational Heart, Lung, and Blood Institute2022 to 2025$2,857,857July 1, 2016March 31, 2027NORRIS, RUSSELLreporter.nih.gov
Altered Lymphatic Function and Development in Congenital Heart DiseaseNIHNational Heart, Lung, and Blood Institute2022 to 2025$2,838,877June 1, 2016May 31, 2027DATAR, SANJEEV A.reporter.nih.gov
Epigenetic regulation in cardiac developmentNIHNational Heart, Lung, and Blood Institute2023 to 2025$2,819,542April 1, 2023March 31, 2030HUANG, YUNreporter.nih.gov
4D Multimodal Image-Based Modeling for Bicuspid Aortic Valve Repair SurgeryNIHNational Heart, Lung, and Blood Institute2022 to 2025$2,803,281June 1, 2022May 31, 2027POUCH, ALISON MARIEreporter.nih.gov
Modern Analytics to Improve Quality & Outcome Assessments Following Congenital Heart SurgeryNIHNational Heart, Lung, and Blood Institute2022 to 2025$2,799,826June 15, 2022May 31, 2027NORMAND, SHARON-LISE TERESAreporter.nih.gov
RE-ENERGIZE FONTAN - RandomizEd Exercise INtERvention desiGned to MaximIZE Fitness in Pediatric FONTAN patientsNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,798,890March 10, 2020February 28, 2026SELAMET TIERNEY, ELIF SEDAreporter.nih.gov
Comparing Direct and Indirect Methods for Cascade Screening in Familial Hypercholesterolemia (FH) and Long QT Syndrome (LQTS)NIHNational Heart, Lung, and Blood Institute2022 to 2025$2,785,718June 1, 2022May 31, 2027BEITELSHEES, AMBER Lreporter.nih.gov
An expandable polymeric valved conduit to repair congenital heart diseaseNIHNational Heart, Lung, and Blood Institute2021 to 2025$2,774,182December 15, 2020November 30, 2026FERRARI, GIOVANNIreporter.nih.gov
Expanding on a new paradigm for MRI in pediatric congenital heart diseaseNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,744,758July 15, 2015March 31, 2026FINN, JOHN PAULreporter.nih.gov
Integrative Approach to Divergent Remodeling in Thin Filament CardiomyopathiesNIHNational Heart, Lung, and Blood Institute2021 to 2025$2,735,889December 1, 2003November 30, 2026TARDIFF, JIL Creporter.nih.gov
Mechanisms of DMP Development and Atrioventricular SeptationNIHNational Heart, Lung, and Blood Institute2021 to 2025$2,723,098September 1, 2014August 31, 2027WESSELS, ARNOreporter.nih.gov
Experimental and Computational Studies in Genetic CardiomyopathiesNIHNational Heart, Lung, and Blood Institute2022 to 2025$2,674,553May 1, 2022April 30, 2027MOUSSAVI-HARAMI, FARIDreporter.nih.gov
Brain Injury and Dysmaturation in Newborns with Congenital Heart Disease Born PretermNIHNational Heart, Lung, and Blood Institute2023 to 2025$2,638,985March 1, 2023February 28, 2028MCQUILLEN, PATRICK SEANreporter.nih.gov
Off-label drugs in cardiology: evaluating age- and disease-appropriate therapiesNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2022 to 2025$2,627,273March 1, 2022February 28, 2027POSNACK, NIKKI GILLUMreporter.nih.gov
Cell fate choices by Tbx1 in forming the mammalian heartNIHNational Heart, Lung, and Blood Institute2021 to 2025$2,603,457August 20, 2020April 30, 2029MORROW, BERNICE Ereporter.nih.gov
Pediatric Heart Disease: Getting from Mutations to TherapeuticsNIHNational Heart, Lung, and Blood Institute2021 to 2023$2,582,324February 15, 2017January 31, 2025GELB, BRUCE Dreporter.nih.gov
Establishing Efficacy for the Congenital Heart Disease Physical Activity Lifestyle InterventionNIHNational Institute of Nursing Research2022 to 2025$2,554,158September 23, 2022June 30, 2027JACKSON, JAMIE L.reporter.nih.gov
Tissue chips for precision treatment of catecholaminergic polymorphic ventricular tachycardiaNIHNational Center for Advancing Translational Sciences2022 to 2024$2,546,193September 1, 2020July 31, 2025PU, WILLIAM TSWENCHINGreporter.nih.gov
Phase IIB Transmural Systems Transcatheter Cavopulmonary Bypass EndograftNIHNational Heart, Lung, and Blood Institute2021 to 2023$2,544,747June 15, 2021November 30, 2024RAFIEE, NASSERreporter.nih.gov
Mechanisms of Clinical and Hemodynamic Response to Pulmonary Vasodilator Therapy in Fontan physiologyNIHNational Heart, Lung, and Blood Institute2022 to 2025$2,530,672December 20, 2021November 30, 2026EGBE, ALEXANDERreporter.nih.gov
Fine-scale Spatiotemporal Mapping of Cellular Regulatory Networks Directing Heart DevelopmentNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2021 to 2024$2,499,248August 1, 2020July 31, 2025CHI, NEIL Creporter.nih.gov
Beyond Gene Dosage: Understanding Down Syndrome via 4D Genome OrganizationNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,496,816September 18, 2020August 31, 2025LI, WENBOreporter.nih.gov
Molecular pathogenesis of congenital heart disease mediated by neural crest and second heart field cellsNIHNational Heart, Lung, and Blood Institute2022 to 2025$2,484,708May 12, 2022April 30, 2027MORROW, BERNICE Ereporter.nih.gov
NEDD4 in right ventricular developmentNIHNational Heart, Lung, and Blood Institute2021 to 2025$2,473,604September 1, 2021August 31, 2026FANG, XIreporter.nih.gov
A system approach to the analysis of Heterotaxy Candidate GenesNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2021 to 2024$2,462,797April 23, 2020January 31, 2025KHOKHA, MUSTAFA Kreporter.nih.gov
An integrated human stem cell model for elucidating myocardial-endocardial interactions in cardiac development and diseaseNIHNational Heart, Lung, and Blood Institute2021 to 2025$2,460,707February 15, 2021January 31, 2027ZHAO, MINGTAOreporter.nih.gov
Obscurin-kinase 1/N-cadherin: a new signaling axis in cardiac structure/functionNIHNational Heart, Lung, and Blood Institute2022 to 2025$2,460,554August 5, 2022May 31, 2027KONTROGIANNI-KONSTANTOPOULOS, AIKATERINIreporter.nih.gov
White Matter Protection in the Fetus with Congenital Heart DiseaseNIHNational Heart, Lung, and Blood Institute2021 to 2023$2,459,987April 1, 2020February 28, 2026ISHIBASHI, NOBUYUKIreporter.nih.gov
A Gata456 Pipeline of DiscoveryNIHNational Heart, Lung, and Blood Institute2021 to 2023$2,432,169January 10, 2017December 31, 2023EVANS, TODD Rreporter.nih.gov
Gene regulatory networks for heart developmentNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,410,652January 1, 2021December 31, 2025BRUNEAU, BENOIT GAETANreporter.nih.gov
A Novel computational approach to optimize Fontan and improve surgical predictabilityNIHNational Heart, Lung, and Blood Institute2022 to 2025$2,410,109February 1, 2022January 31, 2027GOVINDARAJAN, VIJAYreporter.nih.gov
2/2 Milrinone for Prevention of Post-Patent Ductus Arteriosus Closure Syndrome in Extremely Preterm Infants (MIDAS Trial) - DCC ResubmissionNIHNational Heart, Lung, and Blood Institute2024 to 2025$2,393,677July 1, 2024June 30, 2029DAS, ABHIKreporter.nih.gov
Small molecule therapeutic for calcific aortic valve diseaseNIHNational Heart, Lung, and Blood Institute2023 to 2025$2,378,349August 1, 2023May 31, 2027SRIVASTAVA, DEEPAKreporter.nih.gov
Multi-center, randomized, controlled trial of the feasibility and safety of inhaled hydrogen gas during ECPRNIHNational Heart, Lung, and Blood Institute2023 to 2025$2,366,065September 1, 2022August 31, 2026KHEIR, JOHN NAGIreporter.nih.gov
Generation of four-chambered hearts through organoid fusionsNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,358,480September 1, 2024August 31, 2026LI, GUANGreporter.nih.gov
Development of a Mirror-Image Natural Product as an Antiarrhythmic TherapeuticNIHNational Heart, Lung, and Blood Institute2021 to 2023$2,330,311March 17, 2020February 28, 2025JOHNSTON, JEFFREY NICHOLASreporter.nih.gov
Rescue of Autoimmune-Associated Long QT Syndrome by Decoy PeptidesNIHNational Heart, Lung, and Blood Institute2022 to 2025$2,309,947August 19, 2022July 31, 2027BOUTJDIR, MOHAMEDreporter.nih.gov
Cell Therapy for Neuroprotection in Congenital Heart DiseaseNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,294,475December 15, 2017April 30, 2027ISHIBASHI, NOBUYUKIreporter.nih.gov
Genetic and Hemodynamic Effects on Prenatal Cortical Development in Congenital Heart DiseaseNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$2,289,171July 1, 2020March 31, 2026IM, KIHOreporter.nih.gov
Function and regulation of chromatin remodeling complexes in cardiac development and diseaseNIHNational Heart, Lung, and Blood Institute2022 to 2025$2,274,375September 15, 2022July 31, 2026CONLON, FRANK LEOreporter.nih.gov
Oxylipin Signaling in Congenital Heart DiseaseNIHNational Heart, Lung, and Blood Institute2021 to 2025$2,228,649January 1, 2021November 30, 2026AGUIRRE, AITORreporter.nih.gov
Functional Genomics of Cardiac Sodium Channel VariantsNIHNational Heart, Lung, and Blood Institute2021 to 2023$2,197,662January 1, 2020November 30, 2024RODEN, DAN Mreporter.nih.gov
Optogenetic regulation of intra-ciliary calcium signaling in cardiac situs developmentNIHNational Heart, Lung, and Blood Institute2022 to 2025$2,193,015July 1, 2022June 30, 2027YUAN, SHIAULOUreporter.nih.gov
Acute Imposition of Fontan Physiology in The Single Ventricle Patient: Effects on Fibrosis, Function and Drug InterventionNIHNational Heart, Lung, and Blood Institute2021 to 2023$2,190,858July 1, 2020June 30, 2026FOGEL, MARK Areporter.nih.gov
The Risk of Acquired Neonatal Significant brain Injury during perinatal Transition in Congenital Heart Disease: TRANSIT CHD studyNIHNational Institute of Neurological Disorders and Stroke2022 to 2025$2,188,348May 1, 2022February 28, 2027PEYVANDI, SHABNAMreporter.nih.gov
The role of RNA binding proteins in heart development and congenital heart defectsNIHNational Heart, Lung, and Blood Institute2023 to 2025$2,181,968April 12, 2023April 30, 2027KUYUMCU-MARTINEZ, MUGE NESLIHANreporter.nih.gov
Novel function of a mitochondria phosphatase in cardiac developmentNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,163,950July 1, 2021June 30, 2025CHEN, JUreporter.nih.gov
Mechanistic clinical trial of β-blocker administration for reactivating cardiomyocyte division in Tetralogy of FallotNIHNational Heart, Lung, and Blood Institute2021 to 2023$2,148,915July 1, 2021January 31, 2024KUHN, BERNHARDreporter.nih.gov
Mechanism and Function of Cardiac Transcriptional Repression NetworksNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,136,223July 16, 2021June 30, 2025CONLON, FRANK LEOreporter.nih.gov
Development of a Fully-Implantable Ventricular Assist Device for Neonates and Children with Heart Failure - with Magnetic Levitation to Improve HemocompatibilityNIHNational Heart, Lung, and Blood Institute2021 to 2023$2,115,146August 1, 2020June 30, 2025FRAZIER, O. H.reporter.nih.gov
Mechanisms underlying myxomatous valve diseaseNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,112,156August 1, 2021May 31, 2026WAXMAN, JOSHUAreporter.nih.gov
The mechanisms and roles of mitochondria dysfunction in cardiac arrhythmogenesisNIHNational Heart, Lung, and Blood Institute2023 to 2025$2,098,803August 1, 2023May 31, 2027TERENTYEV, DMITRY Areporter.nih.gov
ROS Mechanisms in BAV AortopathyNIHNational Heart, Lung, and Blood Institute2022 to 2024$2,094,708July 1, 2021June 30, 2026GLEASON, THOMAS GILLETTEreporter.nih.gov
Uncertainty aware virtual treatment planning for peripheral pulmonary artery stenosisNIHNational Heart, Lung, and Blood Institute2023 to 2025$2,093,561July 1, 2023June 30, 2028MARSDEN, ALISON Lreporter.nih.gov
2/2 CORD-CHD: Clamp OR Delay among neonates with Congenital Heart DiseaseNIHNational Heart, Lung, and Blood Institute2023 to 2025$2,091,921April 1, 2023March 31, 2030RICE, MADELINE MURGUIAreporter.nih.gov
DEVELOPMENT OF A PULMONARY FLOW RESTRICTOR FOR HYPOPLASTIC LEFT HEART SYNDROMENIHNational Heart, Lung, and Blood Institute2024 to 2025$2,088,353February 15, 2022March 31, 2026TANG, BEVERLYreporter.nih.gov
Proteoglycan Metabolism During Cardiac Valve Development and DiseaseNIHNational Heart, Lung, and Blood Institute2022 to 2025$2,080,075January 1, 2022December 31, 2026KERN, CHRISTINE BRUINSreporter.nih.gov
Linking State Medicaid and Congenital Heart Surgical Registry Data: Building Capacity to Assess Disparities in Longitudinal Outcomes and Value for Children with Congenital Heart DiseaseNIHNational Heart, Lung, and Blood Institute2023 to 2025$2,070,625January 5, 2020June 30, 2030ANDERSON, BRETT ROMEOreporter.nih.gov
5 D impulse mapping in the embryonic heartNIHNational Heart, Lung, and Blood Institute2023 to 2025$2,066,665January 1, 2023December 31, 2026ROLLINS, ANDREW MARTINreporter.nih.gov
A Study Evaluating the Safety and Efficacy of Second-Generation Tissue Engineered Vascular Grafts (TEVG2)NIHNational Heart, Lung, and Blood Institute2021 to 2024$2,061,658September 11, 2019February 28, 2026BREUER, CHRISTOPHER KANEreporter.nih.gov
The Role of PRDM16 in Cardiac Development and CardiomyopathyNIHNational Heart, Lung, and Blood Institute2021 to 2023$2,054,619July 15, 2020May 31, 2025BOUDINA, SIHEMreporter.nih.gov
Signaling by beta 1 integrins regulates ventricular wall morphogenesis and compactionNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,037,504November 15, 2014May 31, 2026WU, MINGFUreporter.nih.gov
Wnt Signaling in Cardiac Conduction and ArrhythmogenesisNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,037,430January 1, 2016February 28, 2026RENTSCHLER, STACEY LYNNreporter.nih.gov
Aortic Valve Disease: Mechanisms and Therapeutic ApproachesNIHNational Heart, Lung, and Blood Institute2021 to 2023$2,037,372February 10, 2020January 31, 2025SRIVASTAVA, DEEPAKreporter.nih.gov
Functional implications of CPVT1-associated RyR2 mutations in human cardiomyocytesNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,028,489September 1, 2021July 31, 2026MORAD, MARTINreporter.nih.gov
Determining the genetic and social determinants of heart failure and mortality in patients with congenital heart diseaseNIHNational Heart, Lung, and Blood Institute2023 to 2025$2,019,406July 1, 2023January 31, 2026LANDSTROM, ANDREW P.reporter.nih.gov
Multimodal AI for Precise Clinical and Genetic Diagnosis of Congenital Heart DiseaseNIHOffice of the Director, National Institutes of Health2025$2,013,196September 8, 2025September 7, 2026MILOSAVLJEVIC, ALEKSANDARreporter.nih.gov
Clinical benefits and mechanism of action of angiotensin-II receptor blocker on Cardiovascular remodeling in patients with repaired coarctation of aortaNIHNational Heart, Lung, and Blood Institute2023 to 2025$2,012,689August 25, 2023July 31, 2028EGBE, ALEXANDERreporter.nih.gov
Change of InstitutionNIHNational Heart, Lung, and Blood Institute2021 to 2023$1,991,250January 1, 2017June 30, 2024BURNS, CAROLINE Ereporter.nih.gov
Lipid Peroxidation-Induced Mitochondrial Injury Inhibits Vascular Function in Single Ventricle Congenital Heart DiseaseNIHNational Heart, Lung, and Blood Institute2023 to 2025$1,984,499July 1, 2023May 31, 2027REDDY, SUSHMAreporter.nih.gov
1/2 percutaneous intervention versus observational trial of arterial ductus in lower gestational age infants (PIVOTAL)NIHNational Heart, Lung, and Blood Institute2023 to 2025$1,979,315March 21, 2022February 28, 2027BACKES, CARLreporter.nih.gov
Integrating Volumetric Light-Field with Computational Fluid Dynamics to Study Myocardial Trabeculation and FunctionNIHNational Heart, Lung, and Blood Institute2021 to 2024$1,975,848August 1, 2021May 31, 2026HSIAI, TZUNG Kreporter.nih.gov
Novel Therapeutics for Timothy Syndrome and Related Cardiac ChannelopathyNIHNational Heart, Lung, and Blood Institute2023 to 2025$1,964,096September 1, 2023May 31, 2027YAZAWA, MASAYUKIreporter.nih.gov
Epigenetic-mediated Notch pathway activation promotes elastin aortopathyNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2023 to 2025$1,957,640February 1, 2023January 31, 2028GREIF, DANIELreporter.nih.gov
Rational Design from Cryo-EM Structures of High-Affinity Ryanodine Receptor Ligands Based on Natural PeptidesNIHNational Heart, Lung, and Blood Institute2023 to 2025$1,951,142July 10, 2023June 30, 2027VALDIVIA, HECTOR Hreporter.nih.gov
Genomic Effects on Right Ventricular Function, Clinical Features and Outcomes in CHDNIHNational Heart, Lung, and Blood Institute2021 to 2024$1,948,211September 30, 2009July 31, 2025NEWBURGER, JANE W.reporter.nih.gov
A Versatile Chemical-Genetic Approach to Determine Bases for Arrhythmogenesis and Sodium ChannelopathiesNIHNational Heart, Lung, and Blood Institute2023 to 2025$1,946,518December 22, 2022November 30, 2026AHERN, CHRISTOPHER Areporter.nih.gov
Endothelial subpopulations in heart valve development and congenital heart diseaseNIHNational Heart, Lung, and Blood Institute2021 to 2024$1,915,051December 15, 2020November 30, 2025YUTZEY, KATHERINE Ereporter.nih.gov
Human iPSC-derived atrial cardiomyocytes to model atrial fibrillation in a dishNIHNational Heart, Lung, and Blood Institute2021 to 2023$1,914,578January 17, 2020December 31, 2024DARBAR, DAWOODreporter.nih.gov
Accelerating research to advance care for adults with congenital heart disease through development of validated scalable computational phenotypesNIHNational Heart, Lung, and Blood Institute2021 to 2023$1,910,551July 10, 2020May 31, 2025OPOTOWSKY, ALEXANDER R.reporter.nih.gov
Engineered BacNav and BacCav for Improved Excitability and ContractionNIHNational Institute of Biomedical Imaging and Bioengineering2022 to 2025$1,900,343May 1, 2022January 31, 2027BURSAC, NENADreporter.nih.gov
Coronary artery dysfunction in OSA: Role of mineralocorticoid receptorsNIHNational Heart, Lung, and Blood Institute2023 to 2025$1,880,847June 1, 2023May 31, 2028BADRAN, MOHAMMADreporter.nih.gov
Mechanisms governing the differentiation and maintenance of atrial identityNIHNational Heart, Lung, and Blood Institute2023 to 2025$1,871,877April 1, 2023March 31, 2027WAXMAN, JOSHUAreporter.nih.gov
The Cardiac Atlas ProjectNIHNational Heart, Lung, and Blood Institute2021 to 2023$1,871,310January 1, 2014June 30, 2025MCCULLOCH, ANDREW D.reporter.nih.gov
Long-term Outcomes after Interventions for Congenital Heart DiseaseNIHNational Heart, Lung, and Blood Institute2021 to 2022$1,858,355April 1, 2014July 31, 2025KOCHILAS, LAZAROS K.reporter.nih.gov
Hyperglycemia of Maternal Diabetes Induces Cardiac Isl1 Positive Progenitor Dysfunction Leading to Heart DefectsNIHNational Heart, Lung, and Blood Institute2021 to 2023$1,845,222August 28, 2020June 30, 2025YANG, PEIXINreporter.nih.gov
Early Prediction of Spontaneous Patent Ductus Arteriosus (PDA) Closure and PDA-Associated OutcomesNIHNational Heart, Lung, and Blood Institute2021 to 2023$1,843,596December 15, 2018November 30, 2025SLAUGHTER, JONATHAN LEEreporter.nih.gov
Partial and Controlled Depletion of SR Calcium by RyR Agonists Prevents Calcium-dependent ArrhythmiasNIHNational Heart, Lung, and Blood Institute2023 to 2025$1,838,106January 1, 2023December 31, 2026VALDIVIA, HECTOR Hreporter.nih.gov
Post-transcriptional regulation of Kv11.1 (hERG) channel expression by alternative splicing and polyadenylationNIHNational Heart, Lung, and Blood Institute2022 to 2025$1,834,304June 1, 2022May 31, 2027ZHOU, ZHENGFENGreporter.nih.gov
Digoxin Pharmacodynamics in Infants with Heart Failure due to Single Ventricle Congenital Heart DiseaseNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2022 to 2024$1,830,595April 1, 2022February 28, 2027HORNIK, CHRISTOPHreporter.nih.gov
Identifying and applying genetic variation relevant to clinical outcomes for individuals with congenital heart diseaseNIHNational Heart, Lung, and Blood Institute2021 to 2024$1,810,339August 1, 2020July 31, 2025SHEN, YUFENGreporter.nih.gov
Cellular Stress-Induced Gene Dysregulation in Heart Defects Formation of Diabetic PregnancyNIHNational Heart, Lung, and Blood Institute2021 to 2023$1,809,936July 1, 2020June 30, 2025YANG, PEIXINreporter.nih.gov
Fetal Brain MRI as a Predictor of Late Neurodevelopmental Outcome in Congenital Heart DiseaseNIHNational Institute of Neurological Disorders and Stroke2022 to 2025$1,800,997January 1, 2022December 31, 2026ROLLINS, CAITLINreporter.nih.gov
Understanding Cardiac C-Looping Using Microscale In Vitro ModelsNIHNational Heart, Lung, and Blood Institute2021 to 2024$1,800,914July 7, 2021May 31, 2026WAN, LEO Q.reporter.nih.gov
Proteomic Profiling of Patent Foramen Ovale Related Neurovascular InjuryNIHNational Institute of Neurological Disorders and Stroke2024$1,795,134July 1, 2010June 30, 2027NING, MINGMINGreporter.nih.gov
Gene x Environment Interactions and Congenital Heart Defects – Illuminating the MechanismsNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2023 to 2025$1,791,765July 21, 2023April 30, 2028ZOHN, IRENE Ereporter.nih.gov
Cardiomyopathy Genomes ProjectNIHNational Heart, Lung, and Blood Institute2021 to 2023$1,786,461May 1, 2015April 30, 2025MCNALLY, ELIZABETH Mreporter.nih.gov
2/2 Percutaneous Intervention Versus Observational Trial of Arterial ductus management in Low-weight infants (PIVOTAL) Data Coordinating CenterNIHNational Heart, Lung, and Blood Institute2022 to 2025$1,778,031March 21, 2022February 28, 2027WISNIEWSKI, STEPHEN Rreporter.nih.gov
IntelliStent: A minimally Invasive, Adjustable Pulmonary Flow Restrictor System for Congenital and Acquired Heart DiseaseNIHNational Heart, Lung, and Blood Institute2025$1,771,084September 1, 2025August 31, 2027BOGNER, SETH ADAMreporter.nih.gov
Developmental Progression of Youth with Critical Congenital Heart DefectsNIHNational Heart, Lung, and Blood Institute2021 to 2023$1,767,874April 1, 2020March 31, 2026VANNATTA, KATHRYNreporter.nih.gov
Alcohol-induced cardiac injury and repair in human induced pluripotent stem cell modelNIHNational Institute on Alcohol Abuse and Alcoholism2021 to 2025$1,760,250April 20, 2021March 31, 2027XU, CHUNHUIreporter.nih.gov
Molecular Mechanisms of Atrial Development and RegenerationNIHNational Heart, Lung, and Blood Institute2023 to 2025$1,759,486July 21, 2017December 31, 2026WAXMAN, JOSHUAreporter.nih.gov
Cellular determinants of cardiopharyngeal multipotency and early fate choicesNIHNational Heart, Lung, and Blood Institute2021 to 2023$1,759,231August 1, 2011May 31, 2024MOGILNER, ALEXANDERreporter.nih.gov
1/2 CORD-CHD: Clamp OR Delay among neonates with Congenital Heart DiseaseNIHNational Heart, Lung, and Blood Institute2024 to 2025$1,758,207April 1, 2023March 31, 2030BACKES, CARLreporter.nih.gov
Coding and Noncoding RNA Contributions to 22q11.2 Deletion SyndromeNIHNational Institute of Allergy and Infectious Diseases2021 to 2024$1,737,187July 1, 2015June 30, 2026VAN OERS, NICOLAI STANISLAS CYRILLEreporter.nih.gov
Shear stress and light-field to elucidate the initiation of cardiac outflow tractNIHNational Heart, Lung, and Blood Institute2021 to 2024$1,736,801July 9, 2015December 31, 2025HSIAI, TZUNG Kreporter.nih.gov
Human Disease-Specific Induced Pluripotent Stem Cells For Preclinical Drug Testing and Drug DiscoveryNIHNational Heart, Lung, and Blood Institute2022$1,728,439March 4, 2022February 28, 2023BUI, LYNNE Areporter.nih.gov
Catheter Based Cardiovascular Device Retrieval SystemNIHNational Heart, Lung, and Blood Institute2021$1,708,264September 24, 2018June 30, 2024GORMAN, JOSEPH Hreporter.nih.gov
Congenital Heart Disease Genetics and Clinical OutcomesNIHNational Heart, Lung, and Blood Institute2021 to 2024$1,698,901September 30, 2009July 31, 2025BRUECKNER, MARTINAreporter.nih.gov
Mechanism-inspired Strategies to Prevent Pathogenic Late Na Current in Cardiac ArrhythmiasNIHNational Heart, Lung, and Blood Institute2023 to 2025$1,678,112February 17, 2023November 30, 2026JOHNY, MANU BENreporter.nih.gov
Bridging the Gap between Genomics and Clinical Outcomes in CHDNIHNational Heart, Lung, and Blood Institute2021 to 2024$1,669,113August 15, 2015July 31, 2025TRISTANI-FIROUZI, MARTINreporter.nih.gov
Deep Learning Based Phenotyping and Outcomes Prediction for Valvular Heart DiseaseNIHNational Heart, Lung, and Blood Institute2024 to 2025$1,667,562May 1, 2024April 30, 2029OUYANG, DAVIDreporter.nih.gov
Potassium channels, membrane potential, and CHDNIHNational Heart, Lung, and Blood Institute2021 to 2023$1,661,160May 1, 2020April 30, 2024KHOKHA, MUSTAFA Kreporter.nih.gov
ATF4 a Novel Regulator of Cardiac DevelopmentNIHNational Heart, Lung, and Blood Institute2023 to 2025$1,634,704May 1, 2023April 30, 2027CHEN, JUreporter.nih.gov
Evaluation of Hedgehog signaling-dependent heart development in a mouse model of Down SyndromeNIHNational Heart, Lung, and Blood Institute2021 to 2023$1,632,091December 26, 2022May 31, 2024MOSKOWITZ, IVAN PAULreporter.nih.gov
Modeling Cerebral Microbleeds and Striatal Brain Iron in Adult Congenital Heart Disease in Relationship to Differential Genetic Risk for Alzheimer DiseaseNIHNational Heart, Lung, and Blood Institute2021 to 2023$1,626,747June 1, 2020May 31, 2025CESCHIN, RAFAEL Creporter.nih.gov
Gene therapy for long QT syndrome type 2NIHNational Heart, Lung, and Blood Institute2024 to 2025$1,622,218April 1, 2024March 31, 2028KOREN, GIDEONreporter.nih.gov
Pharmacological Validation of Vascular KATP Channels for Modulating Ductus Arteriosus ToneNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2021 to 2023$1,619,100September 1, 2020June 30, 2025DENTON, JEROD S.reporter.nih.gov
The interaction of myosin and the thin filament: how mutations cause allosteric dysfunction and their connection to genetic cardiomyopathyNIHNational Heart, Lung, and Blood Institute2021 to 2023$1,611,267December 15, 2010July 31, 2025TARDIFF, JIL Creporter.nih.gov
Developmental and genetic function of SHROOM3NIHNational Heart, Lung, and Blood Institute2023 to 2025$1,607,808March 1, 2023February 28, 2027WARE, STEPHANIE Mreporter.nih.gov
Mechanotransduction by Melusin in Cardiac HypertrophyNIHNational Heart, Lung, and Blood Institute2021 to 2023$1,594,551July 1, 2020June 30, 2025SNIADECKI, NATHAN JOHNreporter.nih.gov
Enhanced Imaging of the Fetal Brain MicrostructureNIHNational Institute of Biomedical Imaging and Bioengineering2022 to 2024$1,579,200March 1, 2022June 30, 2024GHOLIPOUR-BABOLI, ALIreporter.nih.gov
Mechanisms of outflow tract morphogenesis regulated by extracellular matrixNIHNational Heart, Lung, and Blood Institute2023 to 2025$1,559,452June 1, 2023April 30, 2027TARGOFF, KIMARA Lreporter.nih.gov
Identifying unrecognized genetic causes of congenital heart diseaseNIHNational Heart, Lung, and Blood Institute2024 to 2025$1,545,594June 1, 2024March 31, 2028SEIDMAN, CHRISTINE Ereporter.nih.gov
Prenatal valve formation in congenital heart diseaseNIHNational Heart, Lung, and Blood Institute2023 to 2025$1,540,500June 1, 2023April 30, 2027RUGONYI, SANDRAreporter.nih.gov
Cardiac MRI Increases Accuracy and Decreases Risk of Evaluation of Children with Cardiomyopathy and Cardiac TransplantationNIHNational Heart, Lung, and Blood Institute2021 to 2022$1,533,577February 15, 2019April 8, 2022OLIVIERI, LAURA Jreporter.nih.gov
Structure-function analysis for elucidating pathogenicity of cardiac ryanodine receptor genetic variantsNIHNational Heart, Lung, and Blood Institute2021 to 2022$1,533,432July 1, 2019April 30, 2024MARKS, ANDREW ROBERTreporter.nih.gov
A multi-physics simulator for pediatric cardiac surgical planningNIHNational Heart, Lung, and Blood Institute2024 to 2025$1,528,043May 3, 2024April 30, 2029MARSDEN, ALISON Lreporter.nih.gov
Biomechanical Approaches and Technologies for Enhancing TAVR OutcomesNIHNational Institute of Biomedical Imaging and Bioengineering2021 to 2022$1,512,485September 15, 2018December 31, 2024BLUESTEIN, DANNYreporter.nih.gov
Structure and Mechanism of the SET1/COMPASS H3K4 Methyltransferase ComplexNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2021 to 2024$1,511,693September 8, 2020July 31, 2025ZHENG, NINGreporter.nih.gov
Regulation of cardiomyocyte growth in a fetal ovine model of reduced left ventricular fillingNIHNational Heart, Lung, and Blood Institute2024 to 2025$1,506,459July 1, 2024June 30, 2025JONKER, SONNET SKYreporter.nih.gov
Dzip1 and Mitral Valve ProlapseNIHNational Heart, Lung, and Blood Institute2021 to 2023$1,497,789June 1, 2020May 31, 2026NORRIS, RUSSELLreporter.nih.gov
A multidisciplinary approach to understanding feedback and clustering in PCP signalingNIHNational Heart, Lung, and Blood Institute2024 to 2025$1,494,825April 1, 2024March 31, 2028AXELROD, JEFFREY D.reporter.nih.gov
Injectable Biomaterial for Treating Hypoplastic Left Heart SyndromeNIHNational Heart, Lung, and Blood Institute2021 to 2022$1,478,164January 1, 2019December 31, 2023DAVIS, MICHAEL Ereporter.nih.gov
Role of RNA-binding protein DDX3X in heart development and diseaseNIHNational Heart, Lung, and Blood Institute2024 to 2025$1,455,898July 1, 2024June 30, 2028DUBOIS, NICOLEreporter.nih.gov
Pediatric Cardiopulmonary MRI using RF Navigators and High Dimensional Deep LearningNIHNational Heart, Lung, and Blood Institute2024 to 2025$1,454,963July 1, 2024March 31, 2029JOHNSON, KEVIN MICHAELreporter.nih.gov
Amino-terminal acetylation of proteins in mammalian biology and diseaseNIHNational Institute of General Medical Sciences2021 to 2023$1,442,383September 1, 2019July 31, 2025LYON, GHOLSONreporter.nih.gov
The Allogeneic Human Mesenchymal Stem Cell (MSCs) injection in Patients with Hypoplastic Left Heart Sydrome: A Phase IIb Clinical Trial (ELPIS)NIHNational Heart, Lung, and Blood Institute2021 to 2024$1,435,351September 15, 2020August 31, 2025LAI, DEJIANreporter.nih.gov
SSRI Exposure and Ventricular Development from Bench to Bedside: A Prospective Study to Determine if Maternal Depression Treatment Impacts Offspring Cardiac DevelopmentNIHNational Heart, Lung, and Blood Institute2021 to 2024$1,427,056June 1, 2020May 31, 2026HASKELL, SARAH ELIZABETHreporter.nih.gov
Molecular signaling in aortic valve development and congenital aortic valve defectNIHNational Heart, Lung, and Blood Institute2022 to 2023$1,423,514January 1, 2022September 30, 2023ZHOU, BINreporter.nih.gov
Chromatin remodeling factor CHD7 regulates cardiac and craniofacial lymphatic vessel developmentNIHNational Heart, Lung, and Blood Institute2024 to 2025$1,417,874July 25, 2024April 30, 2028LIEN, CHING-LING Ereporter.nih.gov
Mechanisms of morbidity after correcting aortic coarctations of varying severityNIHNational Heart, Lung, and Blood Institute2021 to 2025$1,415,421July 1, 2018April 30, 2028LADISA, JOHN FRANKreporter.nih.gov
Kidney-Associated Diseases after Congenital Heart disease surgery In ChildrenNIHNational Institute of Diabetes and Digestive and Kidney Diseases2024 to 2025$1,396,868March 15, 2024January 31, 2028PARIKH, CHIRAG Rreporter.nih.gov
Identification of compensatory mechanisms to rescue aortic arch artery defectsNIHNational Heart, Lung, and Blood Institute2023 to 2025$1,395,644January 5, 2022December 31, 2026ASTROF, SOPHIEreporter.nih.gov
Defining and perturbing gene regulatory dynamics in the developing human heart to understand mechanisms of congenital heart defectsNIHNational Heart, Lung, and Blood Institute2024 to 2025$1,395,117January 22, 2024December 31, 2027GREENLEAF, WILLIAM JAMESreporter.nih.gov
Integrating Epidemiologic and Genomic Data to Elucidate the Genetic Overlap Between Congenital Anomalies and Pediatric CancerNIHNational Cancer Institute2023 to 2025$1,394,210September 19, 2023August 31, 2028HUFF, CHAD DANIELreporter.nih.gov
Define the mechanisms of aortopathy in bicuspid aortic valve patientsNIHNational Heart, Lung, and Blood Institute2021 to 2022$1,393,504April 13, 2018March 31, 2024YANG, BOreporter.nih.gov
The role of Tie2 signaling in Aortic Valve RemodelingNIHNational Heart, Lung, and Blood Institute2024 to 2025$1,386,256August 10, 2024May 31, 2028BALDWIN, H SCOTTreporter.nih.gov
Cardiovascular disease in fetal alcohol spectrum disorderNIHNational Institute on Alcohol Abuse and Alcoholism2022 to 2025$1,373,520August 10, 2022April 30, 2027BURNS, CAROLINE Ereporter.nih.gov
A Preclinical Study Evaluating and Comparing the Efficacy of Tissue Engineered Vascular Grafts to Polytetrafluoroethylene GraftsNIHNational Heart, Lung, and Blood Institute2022 to 2025$1,370,291June 15, 2022May 31, 2027BREUER, CHRISTOPHER KANEreporter.nih.gov
Safe and Effective MRI for Pediatric Patients with a Cardiac Implantable Electronic DeviceNIHNational Heart, Lung, and Blood Institute2024 to 2025$1,357,652March 1, 2024February 29, 2028GOLESTANI RAD, LALEHreporter.nih.gov
Perinatal cardiomyocyte pruning driven by metabolic maturation: Opportunity for interventionNIHNational Heart, Lung, and Blood Institute2021 to 2022$1,356,525March 15, 2019February 29, 2024JONKER, SONNET SKYreporter.nih.gov
Multi-scale modeling of inherited pediatric cardiomyopathiesNIHNational Heart, Lung, and Blood Institute2021$1,355,405September 1, 2017January 31, 2023PARKER, KEVIN KITreporter.nih.gov
Mechanisms for cell signaling in the control of cardiomyogenesisNIHNational Heart, Lung, and Blood Institute2022 to 2025$1,352,193August 1, 2016August 31, 2026SONG, KUNHUAreporter.nih.gov
Structural Mechanisms of Polycystic Kidney Disease ProteinsNIHNational Institute of Diabetes and Digestive and Kidney Diseases2024 to 2025$1,348,334July 22, 2024April 30, 2028CAO, ERHUreporter.nih.gov
Molecular and cellular mechanisms in cardiac outflow tract formation and defectsNIHNational Heart, Lung, and Blood Institute2021 to 2023$1,344,518September 1, 2021September 30, 2023ZHOU, BINreporter.nih.gov
Mechanisms of de novo cardiac sarcomere assemblyNIHNational Heart, Lung, and Blood Institute2024 to 2025$1,334,378April 1, 2024March 31, 2028DUBOIS, NICOLEreporter.nih.gov
Structural and functional basis of myocardial dysregulation in genetic cardiomyopathyNIHNational Heart, Lung, and Blood Institute2024 to 2025$1,331,834June 15, 2024May 31, 2028KIRK, JONATHAN Areporter.nih.gov
Mechanisms and Therapeutics for Congenital Aortic Valve DiseaseNIHNational Heart, Lung, and Blood Institute2024 to 2025$1,329,648July 5, 2024April 30, 2028GARG, VIDUreporter.nih.gov
Biomechanics of Neural Tube Development using Brillouin-OCT MultimodalityNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2021 to 2022$1,329,503September 1, 2018June 30, 2024LARIN, KIRILL Vreporter.nih.gov
Role of integrin a5b1 in vascular patterning and the formation of the pharyngeal arch arteriesNIHNational Heart, Lung, and Blood Institute2022 to 2024$1,328,249July 1, 2010August 31, 2025ASTROF, SOPHIEreporter.nih.gov
Fast and Accurate Cardiovascular MRI with Hyper 4D-FlowNIHNational Heart, Lung, and Blood Institute2024 to 2025$1,314,238January 1, 2024December 31, 2027ENNIS, DANIEL Breporter.nih.gov
Enabling the Assessment of Fetal Brain Development and Degeneration with Machine LearningNIHNational Institute of Neurological Disorders and Stroke2023 to 2025$1,314,225June 1, 2023May 31, 2028KARIMI, DAVOODreporter.nih.gov
Role of the cardiac neural crest in development and regenerationNIHNational Heart, Lung, and Blood Institute2024 to 2025$1,310,630December 15, 2023November 30, 2027BRONNER, MARIANNEreporter.nih.gov
Transforming Care Delivery Models for at-Risk Young Adult Patients with Congenital Heart Disease and Amplifying Research Efforts to Improve Health Equity in Pediatric Chronic Disease CareNIHNational Institute on Minority Health and Health Disparities2024 to 2025$1,308,575June 18, 2024January 31, 2026LOPEZ, KEILA NATILDEreporter.nih.gov
Heart rate control with bioengineered pacemakersNIHNational Heart, Lung, and Blood Institute2022 to 2024$1,305,622June 5, 2021May 31, 2026CHO, HEE CHEOLreporter.nih.gov
Decrypting Variants of Uncertain Significance in Long-QT SyndromeNIHNational Heart, Lung, and Blood Institute2025$1,297,448August 1, 2014July 31, 2027SANDERS, CHARLES Rreporter.nih.gov
Deciphering the Neonatal Cardiac Regenerative Potential and Regulators in Large AnimalsNIHNational Heart, Lung, and Blood Institute2021 to 2022$1,248,298July 15, 2019June 30, 2025ZHANG, JIANYIreporter.nih.gov
Mechanistic dissection of 22q11.2DS in zebrafishNIHNational Heart, Lung, and Blood Institute2024 to 2025$1,242,466March 1, 2024February 29, 2028BURNS, CAROLINE Ereporter.nih.gov
Mechanistic clinical trial of Beta-blocker administration for reactivating cardiomyocyte division in Tetralogy of FallotNIHNational Heart, Lung, and Blood Institute2024 to 2025$1,233,399July 1, 2021April 30, 2027KUHN, BERNHARDreporter.nih.gov
Molecular signaling in aortic valve development and congenital aortic valve defectNIHNational Heart, Lung, and Blood Institute2024 to 2025$1,220,744January 1, 2022December 31, 2026ZHOU, BINreporter.nih.gov
Impact of Advanced Imaging and Enhanced Risk Profiling on Mitral Valve ProlapseNIHNational Heart, Lung, and Blood Institute2024 to 2025$1,200,248September 1, 2024May 31, 2028MAY, HEIDI THOMASreporter.nih.gov
PRDM16 in cardiac developmentNIHNational Heart, Lung, and Blood Institute2021 to 2023$1,184,792August 20, 2020April 30, 2024CHEN, JUreporter.nih.gov
New Mechanisms of Heterotaxy and Congenital Heart Disease: Nucleoporins at CiliaNIHNational Heart, Lung, and Blood Institute2021 to 2022$1,184,170April 1, 2015November 30, 2023KHOKHA, MUSTAFA Kreporter.nih.gov
Regulation of Cardiomyocyte MaturationNIHNational Heart, Lung, and Blood Institute2021 to 2022$1,177,576March 15, 2019January 31, 2023PU, WILLIAM TSWENCHINGreporter.nih.gov
Congenital Heart Disease Expert Curation PanelNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2022 to 2024$1,170,880August 1, 2022June 30, 2026ROBERTS, AMY Ereporter.nih.gov
Novel Gene-Environment Regulatory Circuit in Chamber-Specific Growth of Perinatal HeartNIHNational Heart, Lung, and Blood Institute2021 to 2023$1,170,000September 1, 2020June 30, 2025TOUMA, MARLINreporter.nih.gov
Novel Signaling Mechanism in Chamber-Specific Postnatal Heart GrowthNIHNational Heart, Lung, and Blood Institute2023 to 2025$1,170,000June 1, 2023May 31, 2028YOKOTA, TOMOHIROreporter.nih.gov
Investigating altered smooth muscle cell mechanotransduction as a cause of supravalvular aortic stenosisNIHNational Heart, Lung, and Blood Institute2023 to 2025$1,169,167December 1, 2022November 30, 2026WAGENSEIL, JESSICAreporter.nih.gov
Electrical Stimulation of Human CPCsNIHNational Heart, Lung, and Blood Institute2022 to 2024$1,162,500February 10, 2020February 28, 2026MAXWELL, JOSHUA THOMASreporter.nih.gov
Multi-Site Validation Study of the HLHS Arrest PredictorNIHNational Heart, Lung, and Blood Institute2021 to 2022$1,159,424July 1, 2018May 31, 2026RUSIN, CRAIG Greporter.nih.gov
Modeling Gene Regulatory Networks for Early Cardiopharyngeal DevelopmentNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2021 to 2022$1,153,555September 1, 2018August 31, 2024SATIJA, RAHULreporter.nih.gov
Readily Available Biological Conduits to Treat Single Ventricle DefectsNIHNational Heart, Lung, and Blood Institute2024 to 2025$1,147,128December 1, 2023November 30, 2027QYANG, YIBINGreporter.nih.gov
Glycosphingolipid-Mediated Cardiomyocyte and Immune Cell Dysfunction in Hypoplastic Left Heart SyndromeNIHNational Heart, Lung, and Blood Institute2024 to 2025$1,142,202June 1, 2024April 30, 2029GARCIA, ANASTACIA Mreporter.nih.gov
Locking and Unlocking Cardiac MaturationNIHNational Heart, Lung, and Blood Institute2025$1,137,498April 1, 2025March 31, 2032KELLY, DANIEL PATRICKreporter.nih.gov
Decoding the transcriptional mechanisms of pericardium formationNIHNational Heart, Lung, and Blood Institute2024 to 2025$1,129,649March 15, 2024February 28, 2028MOSIMANN, CHRISTIANreporter.nih.gov
Linking State Medicaid and Congenital Heart Surgical Registry Data: Building Capacity to Assess Disparities in Longitudinal Outcomes and Value for Children with Congenital Heart DiseaseNIHNational Heart, Lung, and Blood Institute2021 to 2023$1,111,167January 5, 2020September 1, 2023ANDERSON, BRETT ROMEOreporter.nih.gov
Molecular and cellular mechanisms in cardiac outflow tract formation and defectsNIHNational Heart, Lung, and Blood Institute2024$1,107,221September 1, 2021August 31, 2025ZHOU, BINreporter.nih.gov
Proteomic Profiling of Patent Foramen Ovale Related Neurovascular InjuryNIHNational Institute of Neurological Disorders and Stroke2021 to 2023$1,102,500July 1, 2010March 31, 2024NING, MINGMINGreporter.nih.gov
Non-selective Large Conductance Ion Channels In Triggered ArrhythmiaNIHNational Heart, Lung, and Blood Institute2024 to 2025$1,092,708April 1, 2024March 31, 2028KRYSHTAL, DMYTRO O.reporter.nih.gov
Biomechanics of early mammalian cardiogenesisNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2021 to 2022$1,086,902September 1, 2018June 30, 2024LARINA, IRINAreporter.nih.gov
Regulation of cardiac power output in health and diseaseNIHNational Heart, Lung, and Blood Institute2021 to 2022$1,070,114April 1, 2018March 31, 2024GREENBERG, MICHAEL Jreporter.nih.gov
Sodium Channels and Cardiac ArrhythmiasNIHNational Heart, Lung, and Blood Institute2021 to 2022$1,064,606March 15, 2010July 31, 2024DESCHENES, ISABELLEreporter.nih.gov
Quantification of the decline of heart muscle cell proliferation and its reversal in pediatric patientsNIHNational Heart, Lung, and Blood Institute2021 to 2023$1,064,006June 15, 2020January 31, 2024KUHN, BERNHARDreporter.nih.gov
Baylor/Texas Children's Hospital Pediatric Heart NetworkNIHNational Heart, Lung, and Blood Institute2021 to 2023$1,046,091January 1, 2017December 31, 2023PENNY, DANIEL Jreporter.nih.gov
Role of SR-mitochondria interplay in calcium-dependent arrhythmiasNIHNational Heart, Lung, and Blood Institute2024 to 2025$1,032,103January 8, 2024December 31, 2025LIU, BINreporter.nih.gov
Unraveling mechanisms of genome regulation to understand and improve human healthNIHNational Institute of General Medical Sciences2021 to 2023$1,023,089September 9, 2016June 30, 2024COTNEY, JUSTIN LEEreporter.nih.gov
Pediatric Heart Network Regents of the University of MichiganNIHNational Heart, Lung, and Blood Institute2021 to 2023$1,022,892January 1, 2017December 31, 2023GOLDBERG, CAREN Sreporter.nih.gov
Cyclophilin D Regulates Neonatal Cardiac Bioenergetics and FunctionNIHNational Heart, Lung, and Blood Institute2021 to 2022$1,010,948July 15, 2019June 30, 2024PORTER, GEORGE Areporter.nih.gov
Pediatric Heart Network Clinical Research Centers - Boston Children's HospitalNIHNational Heart, Lung, and Blood Institute2024 to 2025$995,626January 1, 2024December 31, 2030DE FERRANTI, SARAH Dreporter.nih.gov
Development of Novel Compounds for Treatment of Heart Arrhythmias in CPVTNIHNational Heart, Lung, and Blood Institute2021$971,323August 21, 2012November 30, 2023SHOTWELL, SANDRA LEEreporter.nih.gov
Identifying and protecting alcohol-sensitive epigenetic changes in congenital heart diseaseNIHNational Institute on Alcohol Abuse and Alcoholism2021 to 2025$960,407September 10, 2021August 31, 2026FORD, STEPHANIE MARIEreporter.nih.gov
A hERG1 potassium channel subdomain is trafficked to the cardiac nucleus: mechanisms and targets of the hERG1NPNIHNational Heart, Lung, and Blood Institute2024 to 2025$954,268July 1, 2024June 30, 2029JONES, DAVID K.reporter.nih.gov
Pediatric Heart Network Emory UniversityNIHNational Heart, Lung, and Blood Institute2021 to 2023$951,177January 1, 2017December 31, 2023MAHLE, WILLIAM Treporter.nih.gov
Pediatric Heart Network New York ConsortiumNIHNational Heart, Lung, and Blood Institute2024 to 2025$948,011January 1, 2024December 31, 2030RICHMOND, MARC ERICreporter.nih.gov
Bicuspid Aortic Valve Biomechanics and CalcificationNIHNational Heart, Lung, and Blood Institute2024 to 2025$937,996March 1, 2024February 29, 2028LINCOLN, JOYreporter.nih.gov
Microphysiology Systems Database Supplement to Tissue Chips for Precision Treatment of Catecholaminergic Polymorphic Ventricular Tachycardia-SupplementNIHNational Center for Advancing Translational Sciences2021$932,065August 1, 2020June 30, 2022PU, WILLIAM TSWENCHINGreporter.nih.gov
Unraveling molecular Complexity of Mitral Valve Disease using single cell and Spatial Multi-Omics analysis"NIHNational Heart, Lung, and Blood Institute2024 to 2025$924,266September 1, 2024June 30, 2028LIU, YANGreporter.nih.gov
Assessing and Promoting Resilience in Adults with Adult Congenital Heart DiseaseNIHNational Heart, Lung, and Blood Institute2021 to 2025$919,866December 3, 2020November 30, 2026STEINER, JILL MARIEreporter.nih.gov
Simulating Cardiac Surgery for Children with Severe Congenital Heart DiseaseNIHNational Heart, Lung, and Blood Institute2022 to 2024$919,196January 3, 2020April 30, 2024HEDJAZI MOGHARI, MEHDIreporter.nih.gov
1/2 CORD-CHD: Clamp OR Delay among neonates with Congenital Heart DiseaseNIHNational Heart, Lung, and Blood Institute2023$907,257April 1, 2023March 31, 2024BACKES, CARLreporter.nih.gov
Pediatric Heart Network Joint Heart Program ConsortiumNIHNational Heart, Lung, and Blood Institute2024 to 2025$903,977January 1, 2024December 31, 2030CNOTA, JAMESreporter.nih.gov
lntegration and Visualization of Diverse Biological DataNIHNational Institute of General Medical Sciences2021 to 2022$896,588April 1, 2005March 31, 2024TROYANSKAYA, OLGA Greporter.nih.gov
Imaging early development of human neural circuitsNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2022 to 2023$894,347August 16, 2022June 30, 2024GHOLIPOUR-BABOLI, ALIreporter.nih.gov
Unraveling mechanisms of genome regulation to understand and improvehuman healthNIHNational Institute of General Medical Sciences2024 to 2025$890,000September 9, 2016July 31, 2027COTNEY, JUSTIN LEEreporter.nih.gov
Novel Zinc-Nanocomposite Materials for Pediatric Bioresorbable Cardiovascular StentsNIHNational Heart, Lung, and Blood Institute2021 to 2022$868,304July 1, 2019June 30, 2025LINSLEY, CHASEreporter.nih.gov
Pediatric Heart Network University of MichiganNIHNational Heart, Lung, and Blood Institute2024 to 2025$867,553January 22, 2024December 31, 2030GOLDBERG, CAREN Sreporter.nih.gov
Pediatric Heart Network (PHN) - Utah CenterNIHNational Heart, Lung, and Blood Institute2024 to 2025$866,234January 8, 2024December 31, 2030WILLIAMS, RICHARD VINCENTreporter.nih.gov
Developing a spatiotemporal lineage map of heart developmentNIHNational Heart, Lung, and Blood Institute2025$865,286August 1, 2025June 30, 2029PU, WILLIAM TSWENCHINGreporter.nih.gov
Mechanism of LV Hypoplasia in Hypoplastic Left Heart SyndromeNIHNational Heart, Lung, and Blood Institute2021$835,541July 1, 2018April 30, 2023TSANG, MICHAEL WAIKOKreporter.nih.gov
Transcatheter vs. Surgical Treatment of Degenerative Mitral Regurgitation: A Comparative Study of Clinical Outcomes, Patient Experiences, and Mechanistic Insights with Multimodality ImagingNIHNational Heart, Lung, and Blood Institute2024$834,249August 1, 2024July 31, 2026GUPTA, AAKRITIreporter.nih.gov
Imaging early development of human neural circuitsNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2024 to 2025$830,676August 1, 2024July 31, 2027GHOLIPOUR-BABOLI, ALIreporter.nih.gov
The electrophysiological properties of embryosNIHNational Heart, Lung, and Blood Institute2024$817,424July 1, 2024June 30, 2028KHOKHA, MUSTAFA Kreporter.nih.gov
Modulation of KCNQ1 channel activityNIHNational Institute of General Medical Sciences2021 to 2022$816,636May 1, 2014December 31, 2023LARSSON, HANS PETERreporter.nih.gov
Mesenchymal Stromal Cell Delivery through Cardiopulmonary Bypass in Pediatric Cardiac SurgeryNIHNational Heart, Lung, and Blood Institute2021$813,164May 21, 2019April 30, 2024ISHIBASHI, NOBUYUKIreporter.nih.gov
1/2 percutaneous intervention versus observational trial of arterial ductus in lower gestational age infants (PIVOTAL)NIHNational Heart, Lung, and Blood Institute2022$812,264March 21, 2022February 28, 2023BACKES, CARLreporter.nih.gov
Calcium and the physiology of diabetesNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2022$810,000May 1, 2019February 29, 2024MARKS, ANDREW ROBERTreporter.nih.gov
Calcium Release Channel Deficiency SyndromeNIHNational Heart, Lung, and Blood Institute2024 to 2025$807,000June 1, 2024March 31, 2028ACKERMAN, MICHAEL JOHNreporter.nih.gov
Ubiquitin Regulation of K Channels in Health and DiseaseNIHNational Heart, Lung, and Blood Institute2021$805,851April 1, 2018February 28, 2022COLECRAFT, HENRY M.reporter.nih.gov
Interpreting coding/non-coding variants for congenital heart disease through gene regulatory networksNIHNational Heart, Lung, and Blood Institute2025$802,762February 1, 2025December 31, 2028HON, GARY CHUNGreporter.nih.gov
Molecular regulation of ventricular chamber maturationNIHNational Heart, Lung, and Blood Institute2021 to 2022$798,709February 15, 2018January 31, 2024LIU, JIANDONGreporter.nih.gov
Oligo-Vascular Crosstalk in the Developing Brain: Implications for White Matter Injury in Congenital Heart DiseaseNIHNational Institute of Neurological Disorders and Stroke2022 to 2024$795,238July 15, 2020June 30, 2025CHAVALI, MANIDEEPreporter.nih.gov
A population-based computational approach for arrhythmia prediction and therapyNIHNational Heart, Lung, and Blood Institute2024 to 2025$787,500July 9, 2024June 30, 2028QU, ZHILINreporter.nih.gov
Metabolic regulation of heart formationNIHNational Heart, Lung, and Blood Institute2021 to 2022$780,000June 1, 2019May 31, 2023NAKANO, ATSUSHIreporter.nih.gov
Placental hemodynamic effects on brain development in infants with congenital heart diseaseNIHNational Heart, Lung, and Blood Institute2022 to 2025$777,536September 1, 2022August 31, 2027LEON, RACHEL Lreporter.nih.gov
Functional characterization of genes and genetic variants associated with hypoplastic heart syndrome in DrosophilaNIHNational Heart, Lung, and Blood Institute2025$777,016August 1, 2025May 31, 2029HAN, ZHEreporter.nih.gov
COMPASS Ancillary NeuroDevelopmental Outcomes(CAN-DO)NIHNational Heart, Lung, and Blood Institute2025$776,754July 15, 2025April 30, 2030WOLFE, KELLY Rreporter.nih.gov
Renal Fitness in Young Adults with Congenital Heart DiseaseNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2023$773,082June 1, 2019September 30, 2025FUHRMAN, DANA YOUNGreporter.nih.gov
Phase II: Rapid Array Diagnosis of Congenital Heart Defects (RAD4CHD) Using Allele Diagnostics Rapid Array Chromosomal Microarray StrategyNIHNational Heart, Lung, and Blood Institute2021$768,564March 1, 2019May 31, 2022TORCHIA, BETHreporter.nih.gov
Epigenetic Mechanisms Underlying Maternal Diabetes Associated Cardiac MalformationsNIHNational Heart, Lung, and Blood Institute2021 to 2022$760,000August 20, 2019July 31, 2025GARG, VIDUreporter.nih.gov
The role of RNA binding proteins in heart development and congenital heart defectsNIHNational Heart, Lung, and Blood Institute2022$759,511May 12, 2022February 7, 2023KUYUMCU-MARTINEZ, MUGE NESLIHANreporter.nih.gov
Decoupling mitral valve-left ventricular fibrotic remodeling in degenerative mitral regurgitation via serotonin 2B receptorNIHNational Heart, Lung, and Blood Institute2025$759,030September 1, 2025May 31, 2029MERRYMAN, WILLIAM Dreporter.nih.gov
Improving transitions of care for adults with congenital heart diseaseNIHNational Heart, Lung, and Blood Institute2022 to 2025$756,984September 8, 2022August 31, 2027AGARWAL, ANUSHREEreporter.nih.gov
TET-mediated epigenetic regulation in cardiac development.NIHNational Heart, Lung, and Blood Institute2021 to 2022$751,928February 15, 2018March 31, 2023HUANG, YUNreporter.nih.gov
Functional dissection of the regulatory network that governs cardiomyocyte maturationNIHNational Heart, Lung, and Blood Institute2022 to 2024$747,000September 1, 2022August 31, 2025VANDUSEN, NATHAN JAMESreporter.nih.gov
The Effects of Estrogen on Cardiac Arrhythmic PropensityNIHNational Heart, Lung, and Blood Institute2023 to 2025$745,035February 10, 2023January 31, 2026ITZHAKI, ILANITreporter.nih.gov
Cell Therapy for Neuroprotection in Congenital Heart DiseaseNIHNational Heart, Lung, and Blood Institute2025$735,704December 15, 2017April 30, 2027ISHIBASHI, NOBUYUKIreporter.nih.gov
Biomechanical indicators of bicuspid aortic valve dysfunctionNIHNational Heart, Lung, and Blood Institute2021$716,097June 1, 2018May 31, 2023SACKS, MICHAEL Sreporter.nih.gov
Functional Cardiovascular 4D MRI in Congenital Heart DiseaseNIHNational Heart, Lung, and Blood Institute2021$709,759September 1, 2012March 31, 2024MARKL, MICHAELreporter.nih.gov
Pediatric Heart Network - GATHER - between Washington University in St Louis and Children's Hospital ColoradoNIHNational Heart, Lung, and Blood Institute2024 to 2025$708,907January 1, 2024December 31, 2030GLATZ, ANDREW CHARLESreporter.nih.gov
AI Driven End-to-End 4D flow MRI Pipeline for Hemodynamic Assessment in BAV DiseaseNIHNational Heart, Lung, and Blood Institute2025$704,234August 5, 2025May 31, 2030MARKL, MICHAELreporter.nih.gov
Regional specific metabolism regulates specification of the Spemann OrganizerNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2024 to 2025$703,250July 10, 2024May 2, 2025KHOKHA, MUSTAFA Kreporter.nih.gov
Development of a Genetic Rabbit Model of Kcnh2-Mediated Epilepsy, SUDEP, & Long QT Syndrome Type 2NIHNational Institute of Neurological Disorders and Stroke2023 to 2024$702,491September 1, 2023February 28, 2025AUERBACH, DAVID SCOTTreporter.nih.gov
CDK13 function in heart development and congenital heart diseaseNIHNational Heart, Lung, and Blood Institute2025$701,842August 1, 2025June 30, 2029WANG, DA-ZHIreporter.nih.gov
Pulmonary vascular glutamine metabolism at the intersection of hemodynamic forces and smooth muscle proliferation in congenital heart diseaseNIHNational Heart, Lung, and Blood Institute2021 to 2024$699,192August 15, 2020July 31, 2025BOEHME, JASONreporter.nih.gov
Artificial Intelligence assisted echocardiography to facilitate optimal image extraction for congenital heart defects diagnosis in Sub-Saharan AfricaNIHNational Heart, Lung, and Blood Institute2023 to 2025$698,589September 20, 2023March 31, 2027LEKE, AMINKENG ZAWUOreporter.nih.gov
ROS mechanisms in BAV aortopathyNIHNational Heart, Lung, and Blood Institute2021$696,823July 1, 2021June 30, 2025GLEASON, THOMAS GILLETTEreporter.nih.gov
Frailty, Aging, and Risk of Adverse Outcomes in Mitral Valve Prolapse (FAR-OUT-MVP Study)NIHNational Heart, Lung, and Blood Institute2021 to 2023$691,163July 1, 2019August 31, 2024STROM, JORDAN BLAIRreporter.nih.gov
A Study Implementing Models for Mechanical Circulatory Support Presurgical Assessment in Congenital Heart Disease Treatment (IMMPACT)NIHNational Heart, Lung, and Blood Institute2022 to 2025$683,424August 25, 2022July 31, 2027FAROOQI, KANWAL MAJEEDreporter.nih.gov
Novel pathogenesis of LVNCNIHNational Heart, Lung, and Blood Institute2025$683,048May 1, 2025March 31, 2030LI, DEQIANGreporter.nih.gov
Impact of Blood Viscosity and Vascular Compliance on Fontan Circulation Dysfunction in ChildrenNIHNational Heart, Lung, and Blood Institute2022 to 2025$679,188March 1, 2022February 28, 2027CHENG, ANDREW Lreporter.nih.gov
Dzip1 and Mitral Valve ProlapseNIHNational Heart, Lung, and Blood Institute2025$678,380June 1, 2020August 31, 2026NORRIS, RUSSELLreporter.nih.gov
Novel Cardiac MRI-Based Predictors for Tetralogy of Fallot: Deformation, Kinematic, and Geometric AnalysesNIHNational Heart, Lung, and Blood Institute2022 to 2025$677,485February 15, 2021January 31, 2027TANDON, ANIMESHreporter.nih.gov
Optical Functional Neuroimaging of Acute and Chronic HypoxiaNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$674,360July 1, 2020June 30, 2025WHITE, BRIAN RICHARDreporter.nih.gov
The Impact of Public Reporting on Procedural Outcomes Following Congenital Heart SurgeryNIHNational Heart, Lung, and Blood Institute2022 to 2025$673,598January 28, 2022December 31, 2026JAYARAM, NATALIEreporter.nih.gov
Integration of RNA and Genome Sequences to Identify Genetic Risk in Hypoplastic Left Heart SyndromeNIHNational Heart, Lung, and Blood Institute2022 to 2025$671,600July 1, 2022June 30, 2027MORTON, SARAH UHLERreporter.nih.gov
Inflammatory and Genetic Cardiomyopathies: Metabolic Phenotyping to Guide Diagnosis and TherapyNIHNational Heart, Lung, and Blood Institute2025$663,578August 15, 2025May 31, 2029NAZER, BABAKreporter.nih.gov
Senescent Cell States in Single Ventricle Disease with Heart FailureNIHNational Heart, Lung, and Blood Institute2025$655,636January 1, 2025July 31, 2025MARTIN, JAMES Freporter.nih.gov
Molecular and Functional Evaluation of NOTCH1 Deficient iPSC Derived Cardiomyocytes in Hypoplastic Left Heart SyndromeNIHNational Heart, Lung, and Blood Institute2022 to 2025$644,544March 10, 2022February 28, 2027SARAF, ANITAreporter.nih.gov
Patient specific 3D printed tissue engineered vascular graft for aortic reconstruction designed by artificial intelligence algorithm.NIHNational Heart, Lung, and Blood Institute2021$643,908July 1, 2018March 31, 2023HIBINO, NARUTOSHIreporter.nih.gov
Hemodynamic Flow-Mediated Myocardial Reprogramming Impacts Cardiac DevelopmentNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2021 to 2022$642,586July 15, 2018May 31, 2024CHI, NEIL Creporter.nih.gov
Nuclear transport of developmental signaling effectorsNIHNational Heart, Lung, and Blood Institute2025$630,169August 20, 2025May 31, 2029KHOKHA, MUSTAFA Kreporter.nih.gov
Coupling gene regulatory and lineage analysis of the cardiac neural crestNIHNational Heart, Lung, and Blood Institute2021$623,632August 15, 2018May 31, 2023BRONNER, MARIANNEreporter.nih.gov
"SHROOM3 is a Novel Cause of Congenital Heart Disease"NIHNational Heart, Lung, and Blood Institute2021 to 2024$620,992July 7, 2020June 30, 2026DURBIN, MATTHEW D.reporter.nih.gov
The electrophysiological properties of embryos TransferNIHNational Heart, Lung, and Blood Institute2025$612,607April 1, 2025April 30, 2028KHOKHA, MUSTAFA Kreporter.nih.gov
Fetal Electrophysiologic Abnormalities in High-risk Pregnancies Associated with Fetal DemiseNIHNational Heart, Lung, and Blood Institute2021$611,689July 1, 2018October 31, 2024STRASBURGER, JANETTE Freporter.nih.gov
Patterning Mechanisms for Ventricular Septation and Congenital Heart DiseaseNIHNational Heart, Lung, and Blood Institute2024$605,275September 19, 2024August 31, 2026KATHIRIYA, IRFAN Sreporter.nih.gov
Remotely Delivered Cardiac Rehabilitation for Adolescents with Congenital Heart DiseaseNIHNational Heart, Lung, and Blood Institute2022 to 2025$603,786July 15, 2022June 30, 2027WHITE, DAVID Areporter.nih.gov
Investigation of hepatic factor in pulmonary arteriovenous malformationsNIHNational Heart, Lung, and Blood Institute2022 to 2025$601,768April 1, 2022March 31, 2027SPEARMAN, ANDREW Dreporter.nih.gov
Mobile Diagnosis of Congenital Genetic Conditions: A Model for Screening and Surveillance in Low-Resource SettingsNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2024 to 2025$601,018February 1, 2024January 31, 2027VILAIN, ERIC J.reporter.nih.gov
Pediatric Heart Network Emory UniversityNIHNational Heart, Lung, and Blood Institute2024 to 2025$600,907January 1, 2024December 31, 2030MAHLE, WILLIAM Treporter.nih.gov
An Engineered Human Ductus Arteriosus Capable of Biomimetic Response to Vasoactive AgentsNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2025$590,565September 1, 2025May 31, 2030SHELTON, ELAINE L.reporter.nih.gov
Ultrasound System for Transational ResearchNIHOffice of the Director, National Institutes of Health2021$589,686September 15, 2021September 14, 2022SINUSAS, ALBERT Jreporter.nih.gov
Machine learning approach to non-invasive MRI-based blood oximetryNIHNational Institute of Biomedical Imaging and Bioengineering2021$587,783September 21, 2021September 20, 2025VARGHESE, JULIET J.reporter.nih.gov
Influence of placental impairments and maternal-fetal environment on neurodevelopmental outcomes in Congenital Heart DiseaseNIHNational Heart, Lung, and Blood Institute2021 to 2024$587,732August 10, 2020June 30, 2025RAJAGOPALAN, VIDYAreporter.nih.gov
Multiscale modeling of inherited cardiomyopathies and therapeutic interventionsNIHNational Heart, Lung, and Blood Institute2021$579,690August 3, 2017January 31, 2023CAMPBELL, KENNETH Sreporter.nih.gov
Novel tau-based diagnostics for neonatal hypoxic-ischemic injuryNIHNational Institute of Neurological Disorders and Stroke2021 to 2023$570,240September 30, 2019August 31, 2024HEFTI, MARCO MATTHIASreporter.nih.gov
Signaling by Shp2 mutants in RASopathiesNIHNational Heart, Lung, and Blood Institute2021$561,333April 1, 2018February 28, 2022BENNETT, ANTON Mreporter.nih.gov
Pulmonary Vascular Development in Single Ventricle Heart Disease: A Longitudinal Biomarker ApproachNIHNational Heart, Lung, and Blood Institute2023 to 2025$560,550January 1, 2023December 31, 2027FRANK, BENJAMIN Sreporter.nih.gov
Development of a Biomimetic Stentless Pulmonary Heart Valve for the Treatment of Pediatric Congenital Heart DiseaseNIHNational Heart, Lung, and Blood Institute2023$553,838May 1, 2023October 31, 2024D'AMORE, ANTONIOreporter.nih.gov
Cardiac interaction networks as determinants of transcriptional specificityNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2021$549,565September 1, 2017May 31, 2023CONLON, FRANK LEOreporter.nih.gov
Regional specific metabolism regulates specification of the Spemann OrganizerNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2025$546,171July 10, 2024June 30, 2029KHOKHA, MUSTAFA Kreporter.nih.gov
A Tailored mHealth Vaping Prevention Intervention for Adolescents with Congenital Heart DefectsNIHNational Heart, Lung, and Blood Institute2023 to 2025$542,424August 15, 2023July 31, 2028FOX, KRISTEN R.reporter.nih.gov
The role Akirin and Pannier interactions during myogenesisNIHNational Institute of General Medical Sciences2022 to 2025$542,000April 15, 2022March 31, 2027NOWAK, SCOTT JAMESreporter.nih.gov
Transcriptional control of endocardial-specific gene expressionNIHNational Heart, Lung, and Blood Institute2025$540,856December 15, 2024November 30, 2028BLACK, BRIAN Lreporter.nih.gov
Role of Valve-Mediated Hemodynamics on Bicuspid AortopathyNIHNational Heart, Lung, and Blood Institute2021$526,338May 1, 2017April 30, 2023BARKER, ALEXANDER J.reporter.nih.gov
Differential Shear Forces on Endocardial Endothelial Cells Regulate a Fibrotic Spectrum in the Left Ventricular Outflow TractNIHNational Heart, Lung, and Blood Institute2021$520,702July 1, 2018May 31, 2023GRANDE-ALLEN, KATHRYN JANEreporter.nih.gov
A Novel Personalized Flow Modeling Paradigm for Fetal Aorta and Its Validation with Fetal Cardiac MRINIHNational Institute of Biomedical Imaging and Bioengineering2024$516,556September 18, 2024August 31, 2027WEI, ZHENGLUN ALANreporter.nih.gov
Towards Precision Medicine for Thoracic Aortic Disease: Defining the Clinical and Genomic Drivers of Bicuspid AortopathyNIHNational Heart, Lung, and Blood Institute2023 to 2025$513,639May 1, 2023April 30, 2028GLOTZBACH, JASON PAULreporter.nih.gov
Multi-Lineage Modulation of cardiac neural crest cells during cardiac developmentNIHNational Heart, Lung, and Blood Institute2024$506,984September 24, 2024August 31, 2025LIN, JIUANN-HUEY IVYreporter.nih.gov
RSV I-PREP: Improving Evidence-Based Implementation of RSV Immuno-Prophylaxis Within Ethical and Policy ContextsNIHNational Heart, Lung, and Blood Institute2023 to 2025$505,440August 1, 2023May 31, 2028SAPER, JENNIFER KUSMAreporter.nih.gov
miRNA buffering mechanisms and phenotypic variability in genetic syndromesNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2024 to 2025$500,500July 17, 2024June 30, 2026ZOHN, IRENE Ereporter.nih.gov
Commercialization Readiness for Ductus Arteriosus Stent to Improve Congenital Heart Defect MortalityNIHNational Heart, Lung, and Blood Institute2024$500,000September 15, 2024August 31, 2025TANG, BEVERLYreporter.nih.gov
Structural and Pharmacological Study of the KCNQ1/KCNE1 Potassium Channel ComplexNIHNational Heart, Lung, and Blood Institute2021 to 2022$498,000July 12, 2018December 31, 2023SUN, JIreporter.nih.gov
Electrical excitability in vascular smooth muscle: from rare disease to new paradigmsNIHNational Heart, Lung, and Blood Institute2023 to 2024$497,998June 1, 2022May 31, 2025MCCLENAGHAN, CONORreporter.nih.gov
Longitudinal Assessment of Cerebrovascular Autoregulation (CA) and Associations to Neurodevelopmental Delays in Infants and Toddlers with and without Congenital Heart Disease (CHD)NIHNational Institute of Nursing Research2021 to 2023$496,884August 27, 2021June 30, 2025TRAN, NHUreporter.nih.gov
DUCTUS ARTERIOSUS STENT TO IMPROVE CONGENITAL HEART DEFECT MORTALITYNIHNational Heart, Lung, and Blood Institute2021$492,571August 6, 2021July 31, 2022TANG, BEVERLYreporter.nih.gov
Machine Learning for CCHD Screening using Dynamic DataNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2023 to 2025$490,471March 10, 2023February 28, 2027SIEFKES, HEATHER Mreporter.nih.gov
Random Field Methods for integrative genomic analysis and high-dimensional risk prediction of congenital heart defectsNIHNational Heart, Lung, and Blood Institute2023$487,567September 8, 2023August 31, 2025LI, MINGreporter.nih.gov
Cardiac MRI increases accuracy and decreases risk of evaluation of children with cardiomyopathy and cardiac transplantationNIHNational Heart, Lung, and Blood Institute2023$486,915February 15, 2019November 30, 2025OLIVIERI, LAURA Jreporter.nih.gov
Does Altered Brain Connectivity Correlate with Developmental Outcomes and Executive Function in Congenital Heart Disease?NIHEunice Kennedy Shriver National Institute of Child Health & Human Development2024 to 2025$486,774July 1, 2024June 30, 2027CHUNG, AI WERNreporter.nih.gov
The role of damage-associated molecular patterns in perioperative morbidities and mortalities of pediatric congenital heart diseasesNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2022 to 2023$486,750August 1, 2022July 31, 2025YUKI, KOICHIreporter.nih.gov
Mediator complex in cardiac development and functionNIHNational Heart, Lung, and Blood Institute2021 to 2022$486,648July 1, 2020June 30, 2023FANG, XIreporter.nih.gov
Integrating imaging and computation to characterize neural crest cells in the myocardial development and regenerationNIHNational Heart, Lung, and Blood Institute2021 to 2022$483,652September 4, 2020August 31, 2024DING, YICHENreporter.nih.gov
Defining New Pathways for Complex Human Heart Failure and ArrhythmiaNIHNational Heart, Lung, and Blood Institute2022 to 2024$482,760April 20, 2020March 31, 2025BRADLEY, ELISA ANNreporter.nih.gov
Integrative Genomic Analysis of Congenital Heart DiseaseNIHNational Heart, Lung, and Blood Institute2021 to 2022$481,162April 1, 2020March 31, 2023JIN, SHENG CHIHreporter.nih.gov
Role of integrin a5b1 in vascular patterning and the formation of the pharyngeal arch arteriesNIHNational Heart, Lung, and Blood Institute2021$478,279July 1, 2010August 31, 2022ASTROF, SOPHIEreporter.nih.gov
Computational Modeling of Right Ventricular Intracardiac Flow in Tetralogy of FallotNIHNational Heart, Lung, and Blood Institute2021 to 2022$477,250December 15, 2020November 30, 2023LOKE, YUE-HINreporter.nih.gov
Enhanced Imaging of the Fetal Brain MicrostructureNIHNational Institute of Biomedical Imaging and Bioengineering2025$469,574March 1, 2022December 31, 2026GHOLIPOUR-BABOLI, ALIreporter.nih.gov
The Role of YAP1:TEAD Enhancers in the Retinoic Acid-Regulatory Network of Cardiac ProgenitorsNIHNational Heart, Lung, and Blood Institute2022$468,721September 12, 2022August 31, 2024ESTARAS, CONCEPCIONreporter.nih.gov
Identification of compensatory mechanisms to rescue aortic arch artery defectsNIHNational Heart, Lung, and Blood Institute2022$468,337January 5, 2022December 31, 2022ASTROF, SOPHIEreporter.nih.gov
Role of RAF1 in human cardiogenesis and congenital heart defectsNIHNational Heart, Lung, and Blood Institute2023$467,728September 23, 2023August 31, 2024JAFFRÉ, FABRICEreporter.nih.gov
Simulating Cardiac Surgery for Children with Severe Congenital Heart DiseaseNIHNational Heart, Lung, and Blood Institute2021$466,872January 3, 2020April 30, 2021HEDJAZI MOGHARI, MEHDIreporter.nih.gov
Developing a CRISPR-based forward-genetic screening method in embryonic zebrafishNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2024$449,350August 1, 2019August 31, 2027HILL, JONATHON Treporter.nih.gov
DEVELOPMENT OF A PULMONARY FLOW RESTRICTOR FOR HYPOPLASTIC LEFT HEART SYNDROMENIHNational Heart, Lung, and Blood Institute2022$448,000February 15, 2022January 31, 2023TANG, BEVERLYreporter.nih.gov
Novel mitochondria-targeting peptides (MTPs) as therapeutic intervention in Barth syndromeNIHNational Heart, Lung, and Blood Institute2025$445,500January 15, 2025December 31, 2027SANDLERS, YANA Ireporter.nih.gov
Role of congenital heart defects in motor skills and language acquisition of infants with Down syndromeNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2024 to 2025$441,846June 1, 2024May 31, 2027WU, JIANHUAreporter.nih.gov
NOTCH signaling on the underdeveloped cardiac vascularization of hypoplastic left heart syndrome in the hiPSC-derived vascularized cardiac organoidsNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2022$438,157September 8, 2022August 31, 2025YANG, HUAXIAOreporter.nih.gov
Toward Patient-Specific Computational Modeling of Tricuspid Valve Repair in Hypoplastic Left Heart SyndromeNIHNational Heart, Lung, and Blood Institute2023 to 2025$436,901September 1, 2023August 31, 2027WU, WENSIreporter.nih.gov
An Integrated and Automated Tool for Quantification of Biomechanics in Fetal and Neonatal EchocardiographyNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2022 to 2023$431,893September 15, 2022August 31, 2025VLACHOS, PAVLOS Preporter.nih.gov
A growth-accommodating transcatheter pulmonary valve system for young childrenNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2021 to 2022$431,750July 7, 2021June 30, 2024KHERADVAR, ARASHreporter.nih.gov
Mechanisms of second heart field development regulated by Nkx genesNIHNational Heart, Lung, and Blood Institute2021$429,539January 1, 2017December 31, 2023TARGOFF, KIMARA Lreporter.nih.gov
Dissecting SARS-CoV-2 infection in Down syndrome with congenital heart defects using patient-specific iPSCsNIHNational Heart, Lung, and Blood Institute2022 to 2023$429,000September 6, 2022July 31, 2025ZHAO, MINGTAOreporter.nih.gov
Brain Metabolites, Brain Antioxidant, and Cerebral Blood Flow Deficits in Single Ventricle Heart DiseaseNIHNational Institute of Neurological Disorders and Stroke2023 to 2024$429,000February 1, 2023January 31, 2026KUMAR, RAJESHreporter.nih.gov
Potassium channels and uteroplacental vessels function in pregnant long QT type 1 womenNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2023 to 2024$427,625March 8, 2023February 28, 2026LORCA, RAMON Areporter.nih.gov
Disparities in the effect of state policy for the newborn screening for critical congenital heart diseasesNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2021 to 2022$423,775September 23, 2021August 31, 2024SAKAI-BIZMARK, RIEreporter.nih.gov
Exploring the role of mitochondria in dysregulated calcium handling in diseased heartsNIHNational Heart, Lung, and Blood Institute2021$422,652June 10, 2021May 31, 2024LIU, BINreporter.nih.gov
Defining the spatio-temporal mechanisms of ventricular cell specification and differentiationNIHNational Heart, Lung, and Blood Institute2021$421,237February 15, 2018January 31, 2023DUBOIS, NICOLEreporter.nih.gov
Heart rate control with bioengineered pacemakersNIHNational Heart, Lung, and Blood Institute2021$415,881June 5, 2021January 31, 2022CHO, HEE CHEOLreporter.nih.gov
Mechanisms of cardiomyocyte-extracellular matrix interactions in cardiogenesisNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2021$411,542September 1, 2021August 31, 2025SCHUMACHER, JENNIFERreporter.nih.gov
Multi-center, randomized, controlled trial of the feasibility and safety of inhaled hydrogen gas during ECPRNIHNational Heart, Lung, and Blood Institute2022$410,558September 1, 2022August 31, 2023KHEIR, JOHN NAGIreporter.nih.gov
Transformation of metal oxide nanomaterials in wildland-urban interface fires causes congenital heart diseaseNIHNational Institute of Environmental Health Sciences2025$409,750January 18, 2025January 17, 2027AZHAR, MOHAMADreporter.nih.gov
Mobile Diagnosis of Congenital Genetic Conditions: A Model for Screening and Surveillance in Low-Resource SettingsNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2021$409,475September 1, 2021January 31, 2024LINGURARU, MARIUS GEORGEreporter.nih.gov
Regulation of cardiac patterning via Akirin/NuRD InteractionsNIHNational Heart, Lung, and Blood Institute2022$406,267September 5, 2022August 31, 2025BRYANTSEV, ANTONreporter.nih.gov
Development of a Genetic Rabbit Model of Kcnh2-Mediated Epilepsy, SUDEP, & Long QT Syndrome Type 2NIHNational Institute of Neurological Disorders and Stroke2025$405,611September 1, 2023August 31, 2026AUERBACH, DAVID SCOTTreporter.nih.gov
Development and Validation of a High-Fidelity Cardiac Presurgical Planning Platform for Congenital Heart Defects Using 3D Printing TechnologyNIHNational Heart, Lung, and Blood Institute2025$400,016September 10, 2025May 9, 2027KELLY, TYLERreporter.nih.gov
Personalized Computational Modeling for Predicting Hemodynamics in Borderline Left VentriclesNIHNational Library of Medicine2024 to 2025$397,943August 7, 2024July 31, 2026VEDULA, VIJAYreporter.nih.gov
Retinoic acid-dependent epigenetic and transcriptional mechanisms controlling heart developmentNIHNational Heart, Lung, and Blood Institute2021$397,500February 1, 2018January 31, 2023WAXMAN, JOSHUAreporter.nih.gov
Rtf1-dependent transcriptional regulation of heart developmentNIHNational Heart, Lung, and Blood Institute2021$394,500July 1, 2018April 30, 2023CHEN, JAU-NIANreporter.nih.gov
Functional screen for genetic causes of hypoplastic left heart syndromeNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2023 to 2024$390,901April 1, 2023March 31, 2026NIE, SHUYIreporter.nih.gov
Electrical stimulation of human CPCsNIHNational Heart, Lung, and Blood Institute2021$390,000February 10, 2020August 30, 2021MAXWELL, JOSHUA THOMASreporter.nih.gov
KCNJ2-Induced Arrhythmia Mechanisms in CPVT and Heart Failure.NIHNational Heart, Lung, and Blood Institute2021$381,228August 1, 2018July 31, 2023ECKHARDT, LEE LOCHBAUMreporter.nih.gov
Investigating the role of H2A.Z dynamics in regulating cardiac lineage commitmentNIHNational Heart, Lung, and Blood Institute2021$380,935February 1, 2018January 31, 2024BOYER, LAURIE Areporter.nih.gov
Patient Specific Tissue Engineered Vascular Graft Creation Using 3D Printing TechnologyNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2021$372,963January 1, 2017December 31, 2022HIBINO, NARUTOSHIreporter.nih.gov
Computational Prioritization of Coding and Non-Coding Variants in Congenital Heart DiseaseNIHNational Heart, Lung, and Blood Institute2021 to 2022$370,856September 1, 2021August 31, 2024MORTON, SARAHreporter.nih.gov
Physiologic and Genetic Contributions of Impaired Fetal Brain Development in Congenital Heart DiseaseNIHNational Heart, Lung, and Blood Institute2021 to 2022$363,388April 1, 2019March 31, 2023ORTINAU, CYNTHIA MARIEreporter.nih.gov
Optimizing Congenital Aortic Valve Surgery with Simulation-Guided DesignNIHNational Heart, Lung, and Blood Institute2024 to 2025$363,264August 16, 2024July 31, 2029KAISER, ALEXANDER Dreporter.nih.gov
Uncovering the DNA recognition rules of cardiac transcription factorsNIHNational Institute of General Medical Sciences2021$356,820June 1, 2018May 31, 2025RODRIGUEZ-MARTINEZ, JOSE Areporter.nih.gov
Fetal Brain Development in Congenital Heart DiseaseNIHNational Institute of Neurological Disorders and Stroke2021 to 2022$351,833January 1, 2022December 31, 2022ROLLINS, CAITLINreporter.nih.gov
An automated system to interpret echocardiography to predict adverse outcomes in patients with right ventricular dysfunction in daily hospital practiceNIHNational Heart, Lung, and Blood Institute2021$346,545August 15, 2021July 31, 2023SCHILLING, JAMES Wreporter.nih.gov
1/2 Milrinone for Prevention of Post-Patent Ductus Arteriosus Closure Syndrome in Extremely Preterm Infants (MIDAS Trial) – CCCNIHNational Heart, Lung, and Blood Institute2024$342,731July 1, 2024June 30, 2025MCNAMARA, PATRICK Jreporter.nih.gov
Novel molecular therapies for CPVTNIHNational Heart, Lung, and Blood Institute2021 to 2022$340,330July 12, 2018June 30, 2023BEZZERIDES, VASSILIOS JAMESreporter.nih.gov
Biogenesis of hERG1a/1b ion channels in health and disease model cardiomyocytesNIHNational Heart, Lung, and Blood Institute2023 to 2024$339,294July 5, 2024June 30, 2025FLORES ALDAMA, LISANDRAreporter.nih.gov
The Role of End-Binding Protein 2 and Microtubule Network in Inherited Cardiac ArrhythmiasNIHNational Heart, Lung, and Blood Institute2022 to 2023$336,416August 1, 2022January 31, 2025CHIANG, DAVID YI-ENGreporter.nih.gov
Statistical Methods for Analyzing Birth Defects CohortsNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2021 to 2022$335,000April 1, 2021March 31, 2025ZHAO, HONGYUreporter.nih.gov
Mural cells contribution to vascular remodeling in flow induced pulmonary hypertensionNIHNational Heart, Lung, and Blood Institute2024 to 2025$332,843September 20, 2024August 31, 2029KLOUDA, TIMOTHYreporter.nih.gov
Moonlighting in Mitochondria: A Non-Canonical Role for Cardiac Troponin I in Inherited CardiomyopathiesNIHNational Heart, Lung, and Blood Institute2024 to 2025$331,344August 1, 2024July 31, 2029ELEZABY, ALYreporter.nih.gov
The Association of Damaging Genetic Variation With Ventricular Function in Hypoplastic Left Heart SyndromeNIHNational Heart, Lung, and Blood Institute2021 to 2022$323,936August 1, 2018July 31, 2024LEWIS, MATTHEWreporter.nih.gov
Expandable Pediatric Pulmonary Heart ValveNIHNational Heart, Lung, and Blood Institute2025$321,679September 1, 2025August 31, 2027SIERAD, LESLIE NEILreporter.nih.gov
A Fail Safe, High Output Failing Fontan PumpNIHNational Heart, Lung, and Blood Institute2025$320,838September 5, 2025February 28, 2027SMITH, WILLIAM Areporter.nih.gov
Computational analysis of whole genome sequence data for discovering novel risk genes of structural birth defectsNIHNational Heart, Lung, and Blood Institute2022 to 2023$319,230August 1, 2022July 31, 2025SHEN, YUFENGreporter.nih.gov
Genetic Contributions to Valvar Pulmonary StenosisNIHNational Heart, Lung, and Blood Institute2022 to 2023$318,000July 19, 2022June 30, 2024WEAVER, KATHRYN NICOLEreporter.nih.gov
Uncovering incomplete penetrance genes in congenital heart disease by integrative analysis of Common Fund dataNIHOffice of the Director, National Institutes of Health2025$316,000June 10, 2025May 31, 2027KOBOLDT, DANIELreporter.nih.gov
Enriching medical phenotypes and environmental traits in the large DS360 Down syndrome cohortNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2022$313,000May 1, 2022April 30, 2025ROSSER, TRACIE Creporter.nih.gov
Curation and analysis of publicly available, molecular profiles from people with Down SyndromeNIHNational Heart, Lung, and Blood Institute2024 to 2025$310,521June 1, 2024May 31, 2027PICCOLO, STEPHENreporter.nih.gov
Mechanisms for cell signaling in the control of cardiomyogenesisNIHNational Heart, Lung, and Blood Institute2022$309,589August 1, 2016August 15, 2023SONG, KUNHUAreporter.nih.gov
Biomimetic size-adaptable heart valve for prosthesis-patient mismatchNIHNational Heart, Lung, and Blood Institute2021$299,994January 1, 2021December 31, 2021DEL NIDO, PEDRO J.reporter.nih.gov
1/2 Milrinone for Prevention of Post-Patent Ductus Arteriosus Closure Syndrome in Extremely Preterm Infants (MIDAS Trial) – CCCNIHNational Heart, Lung, and Blood Institute2025$296,469July 1, 2024June 30, 2029MCNAMARA, PATRICK Jreporter.nih.gov
Multi-scale computational modeling of calmodulin mutations associated with CPVTNIHNational Institute of General Medical Sciences2024 to 2025$295,000May 1, 2024April 30, 2028SHIFERAW, YOHANNESreporter.nih.gov
Sphingosine kinase 1 plays a key role in defective elastin-induced arterial hypermuscularizationNIHNational Heart, Lung, and Blood Institute2024 to 2025$279,158April 1, 2024August 31, 2025SAITO, JUNICHIreporter.nih.gov
Gene Expression Networks for Human Cardiac Differentiation in Down SyndromeNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2021$277,548September 1, 2020August 31, 2023MOSKOWITZ, IVAN PAULreporter.nih.gov
Newborn Screening for Critical Congenital Heart Disease in U.S.: Assessment of implementation obstacles and application of cost-effectiveness to gauge if action needed for improved implementationNIHNational Heart, Lung, and Blood Institute2021 to 2022$275,156June 1, 2018May 31, 2024SAKAI-BIZMARK, RIEreporter.nih.gov
Determination of Persistent Inflammation, Immunosuppression, and Catabolism Syndrome in the Pediatric Cardiac ICUNIHNational Heart, Lung, and Blood Institute2025$271,938August 15, 2025July 31, 2027STARK, RYAN Jreporter.nih.gov
Multimodal Characterization of Cardiac-Neurodevelopmental GenesNIHNational Heart, Lung, and Blood Institute2025$267,000August 1, 2025July 31, 2027MORTON, SARAH UHLERreporter.nih.gov
Impact of phthalate and phenol exposures on congenital heart surgery outcomesNIHNational Institute of Environmental Health Sciences2022$259,073May 18, 2022April 30, 2023KUIPER, JORDAN RICHARDreporter.nih.gov
Deciphering the intrinsic myocardial and/or endocardial defects of hypoplastic left heart syndromeNIHNational Heart, Lung, and Blood Institute2024 to 2025$254,556March 1, 2024February 28, 2027HUANG, MENGMENGreporter.nih.gov
Critical roles of CHD7 during mouse cardiogenesisNIHNational Heart, Lung, and Blood Institute2021$253,153January 1, 2010March 31, 2022JIAO, KAIreporter.nih.gov
Systems biology of acute and chronic multi-organ failure in children with congenital heart diseaseNIHNational Heart, Lung, and Blood Institute2024 to 2025$252,118September 1, 2024August 31, 2029DAVIDSON, JESSEreporter.nih.gov
Cellular and Molecular Mechanisms of Atrial Cardiomyocyte Lineage CommitmentNIHNational Heart, Lung, and Blood Institute2021$249,998April 15, 2019March 31, 2022LI, GUANGreporter.nih.gov
Electrical excitability in vascular smooth muscle: from rare disease to new paradigmsNIHNational Heart, Lung, and Blood Institute2022$249,000June 1, 2022May 31, 2023MCCLENAGHAN, CONORreporter.nih.gov
Sphingosine kinase 1 plays a key role in defective elastin-induced arterial hypermuscularizationNIHNational Heart, Lung, and Blood Institute2025$249,000September 1, 2025August 31, 2028SAITO, JUNICHIreporter.nih.gov
The Role of End-Binding Protein 2 and Microtubule Network in Inherited Cardiac ArrhythmiasNIHNational Heart, Lung, and Blood Institute2025$248,363April 18, 2025March 31, 2028CHIANG, DAVID YI-ENGreporter.nih.gov
SCN5A (Nav1.5): Predicting the Consequence of Missense Single- Nucleotide Polymorphisms.NIHNational Heart, Lung, and Blood Institute2021$246,330February 5, 2019January 31, 2022KRONCKE, BRETT Mreporter.nih.gov
Intrauterine Programming of Diabetes Induced Cardiac EmbyropathyNIHNational Heart, Lung, and Blood Institute2021 to 2022$246,240January 1, 2018December 31, 2023LISTER, ROLANDA LAMORAreporter.nih.gov
Novel Therapeutics for Long QT SyndromeNIHNational Heart, Lung, and Blood Institute2022$245,540September 22, 2022June 30, 2023YAZAWA, MASAYUKIreporter.nih.gov
Mentoring in Pediatric Cardiovascular Pharmacology and Early Phase TrialsNIHNational Heart, Lung, and Blood Institute2024 to 2025$242,118March 1, 2024February 28, 2029HORNIK, CHRISTOPHreporter.nih.gov
Cyclic stretch of bicuspid aortic valves: elucidating its implications for cell signaling and tissue mechanics.NIHNational Heart, Lung, and Blood Institute2023 to 2025$239,068April 1, 2023March 31, 2026WEST, TONI MCCLISHreporter.nih.gov
Machine Learning Based Analysis of Longitudinal Changes in the Congenital Heart Disease ElectrocardiogramNIHNational Heart, Lung, and Blood Institute2024 to 2025$234,750August 1, 2024July 31, 2027BOOK, WENDY M.reporter.nih.gov
Secondary Analysis of Noninvasive Imaging Biomarkers for the Early Prediction of Single Ventricle FailureNIHNational Heart, Lung, and Blood Institute2025$234,000August 1, 2025July 31, 2027HUNTER, KENDALL STEPHENreporter.nih.gov
Natural language processing and machine learning for development of a Fontan Failure risk prediction model from electronic health recordsNIHNational Heart, Lung, and Blood Institute2025$232,498August 15, 2025July 31, 2027BOOK, WENDY M.reporter.nih.gov
A Multi-omic approach towards improving candidate gene identification and variant prioritization in patients with congenital heart diseaseNIHNational Heart, Lung, and Blood Institute2022 to 2023$231,000January 1, 2022December 31, 2024GARG, VIDUreporter.nih.gov
Functional assessment of atrial myosin mutations in familial atrial arrhythmiaNIHNational Heart, Lung, and Blood Institute2025$231,000September 1, 2025August 31, 2027KAWANA, MASATAKAreporter.nih.gov
Random Field Modelling of genetic and epigenetic association underlying congenital heart defects in the presence of disease heterogeneityNIHNational Heart, Lung, and Blood Institute2021$218,783January 1, 2021January 9, 2023LI, MINGreporter.nih.gov
Mechanisms linking the frail sarcomere to noncompaction cardiomyopathyNIHNational Heart, Lung, and Blood Institute2023 to 2024$217,870August 1, 2023July 31, 2025MONROE, TANNER Oreporter.nih.gov
Primary cilia as regulators of vascular stability during embryonic developmentNIHNational Heart, Lung, and Blood Institute2024 to 2025$216,810July 1, 2024June 30, 2027WILSON-COLIJN, SARAH ANNreporter.nih.gov
Impact of phthalate and phenol exposures on congenital heart surgery outcomes.NIHNational Institute of Environmental Health Sciences2023$213,595May 18, 2022April 30, 2025KUIPER, JORDAN RICHARDreporter.nih.gov
Acute Prenatal Alcohol Exposure Potentiates Conotruncal Defects in the Setting of a Permissive Genetic BackgroundNIHNational Institute on Alcohol Abuse and Alcoholism2022 to 2025$212,959May 18, 2022May 17, 2027HARVEY, DRAYTON Creporter.nih.gov
A Platform for Outcomes Data Sharing and Pre-Operative Image-Guided Mechanistic Assessment for Bicuspid Aortic Valve Repair SurgeryNIHNational Heart, Lung, and Blood Institute2021 to 2022$211,356September 1, 2018May 31, 2023POUCH, ALISON MARIEreporter.nih.gov
Regulation of Fibronectin expression in the neural crest during vascular morphogenesisNIHNational Heart, Lung, and Blood Institute2021 to 2022$206,854April 1, 2020March 31, 2023ALEXANDER, BRIANNAreporter.nih.gov
Right Ventricular Remodeling in Tetralogy of FallotNIHNational Heart, Lung, and Blood Institute2022 to 2025$206,439August 1, 2022July 31, 2027THOMPSON, ELIZABETH WALKERreporter.nih.gov
Heart Failure in Single Right Ventricle Physiology: Pathologic Mechanisms and Novel AssessmentNIHNational Heart, Lung, and Blood Institute2021$200,772August 1, 2017June 30, 2023CHOWDHURY, SHAHRYAR M.reporter.nih.gov
Probing mechanisms of long QT type 2-associated neuronal dysfunction using gene-edited stem cell-derived neuronsNIHNational Institute of Neurological Disorders and Stroke2025$195,000December 1, 2024November 30, 2026JONES, DAVID K.reporter.nih.gov
Evaluation of First-Degree Relatives after Sudden Unexplained DeathNIHNational Heart, Lung, and Blood Institute2021$190,008August 1, 2017June 30, 2022WEBSTER, ROBERT GREGORYreporter.nih.gov
Fetal markers of neurodevelopmental outcomes in congenital heart diseaseNIHNational Institute of Neurological Disorders and Stroke2021$188,245June 1, 2017May 31, 2022PEYVANDI, SHABNAMreporter.nih.gov
Uncovering the Mechanism of Potassium Channel Folding and Assembly with Implications for the Molecular Basis of Cardiac ArrhythmiaNIHNational Heart, Lung, and Blood Institute2022 to 2025$185,889January 1, 2022June 30, 2025MOLINA, ANDREW VINCENTreporter.nih.gov
Immune system evasion of stem cell-derived cardiomyocytesNIHNational Heart, Lung, and Blood Institute2021 to 2022$183,957July 14, 2020July 18, 2022GARBERN, JESSICAreporter.nih.gov
Defining the molecular regulators of valvular delamination via multi-omic dissection of Ebstein’s AnomalyNIHNational Heart, Lung, and Blood Institute2021 to 2024$183,044April 1, 2021March 31, 2025MERRIMAN, ALEXANDER FLAHERTYreporter.nih.gov
Ventricular and Pulmonary Vascular Reserve after the Fontan OperationNIHNational Heart, Lung, and Blood Institute2021$173,275April 1, 2018July 31, 2021EGBE, ALEXANDERreporter.nih.gov
Developing near-infrared responsive liquid crystal elastomers for an adjustable pulmonary artery bandNIHNational Heart, Lung, and Blood Institute2022 to 2025$172,354August 17, 2022August 16, 2026SKILLIN, NATHANIEL PHILLIPreporter.nih.gov
Genome Editing Treatment for Catecholaminergic Polymorphic Ventricular TachycardiaNIHNational Heart, Lung, and Blood Institute2021 to 2024$172,170March 1, 2021September 30, 2024MOORE, OLIVERreporter.nih.gov
Novel Cardiac MRI-Based Predictors for Tetralogy of Fallot: Deformation, Kinematic, and Geometric AnalysesNIHNational Heart, Lung, and Blood Institute2021$169,351February 15, 2021September 1, 2021TANDON, ANIMESHreporter.nih.gov
Prenatal Care and Postnatal Outcomes for Publicly Insured Children with Congenital Heart DefectsNIHNational Heart, Lung, and Blood Institute2025$168,480April 10, 2025March 31, 2030WOO, JOYCE Lreporter.nih.gov
Precision Prediction of Right Ventricular Size, Function, and Outcomes in Patients with Repaired Tetralogy of FallotNIHNational Heart, Lung, and Blood Institute2025$167,588March 1, 2025February 28, 2030DUONG, SON QUANGreporter.nih.gov
Functional Characterization of Phosphodiesterase 1 in Single Ventricle Heart DiseaseNIHNational Heart, Lung, and Blood Institute2021$165,240January 1, 2017December 31, 2022NAKANO, STEPHANIE JIALINGreporter.nih.gov
A genetic and molecular approach to understanding allelic and phenotypic heterogeneity in Acrofacial dysostosis, Cincinnati-typeNIHNational Heart, Lung, and Blood Institute2021$162,980April 11, 2019March 31, 2023WEAVER, KATHRYN NICOLEreporter.nih.gov
Identifying Angiocrine Factors for Cardiomyocyte Maturation Using Single-Cell SequencingNIHNational Heart, Lung, and Blood Institute2021$162,432February 1, 2020January 31, 2023PAIK, DAVID Treporter.nih.gov
Establishing Basic Science-Clinical Collaborations to Understand the Molecular Mechanisms of HeterotaxyNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2024$161,500August 1, 2024July 31, 2026KULKARNI, SAURABH Sreporter.nih.gov
Defining new pathways for complex human heart failure and arrhythmiaNIHNational Heart, Lung, and Blood Institute2021$160,920April 20, 2020July 31, 2021BRADLEY, ELISA ANNreporter.nih.gov
The Role of RERE and SPEN in the development of 1p36 Deletion-Related Congenital Heart DefectsNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2024$160,000July 22, 2024June 30, 2026SCOTT, DARYL ARMSTRONGreporter.nih.gov
Revealing the mechanisms of neural-mediated cardiac proliferation in Ciona robustaNIHNational Heart, Lung, and Blood Institute2023 to 2024$159,984September 1, 2023August 31, 2026GRUNER, HANNAHreporter.nih.gov
A Dynamic and Three-Dimensional Human Model of Hypoplastic Left Heart Syndrome to Probe Compromised Cardiomyocyte ProliferationNIHNational Heart, Lung, and Blood Institute2024 to 2025$156,980September 16, 2024September 15, 2027ALONZO, MATTHEWreporter.nih.gov
Dissecting the spectrum of genetic architectures underlying congenital heart defects.NIHNational Heart, Lung, and Blood Institute2021$156,000January 1, 2020December 31, 2022ARBOLEDA, VALERIE Areporter.nih.gov
Maternal dietary intake of omega 3 fatty acids and birth defectsNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2023 to 2024$156,000May 18, 2023July 31, 2025WALLER, DOROTHY KIMreporter.nih.gov
Assessing myofilament phenotype and contractile response to pharmacotherapies in a human induced pluripotent stem cell cardiomyocyte (hiPSC-CM) model of hypoplastic left heart syndrome (HLHS)NIHNational Heart, Lung, and Blood Institute2021 to 2022$155,500August 3, 2021July 31, 2023NAKANO, STEPHANIE JIALINGreporter.nih.gov
Targeting pathologic intracellular calcium release to prevent lethal arrhythmiasNIHNational Heart, Lung, and Blood Institute2023 to 2025$149,235June 1, 2023May 31, 2026GOCHMAN, AARONreporter.nih.gov
3D Bioprinted Collagen Vascular Conduits For Use In Patients With Congenital Heart DefectsNIHNational Heart, Lung, and Blood Institute2022 to 2023$145,616September 1, 2022June 30, 2024ASHRAF, SYED FAAZreporter.nih.gov
Biomechanical Optimization of Mitral Valve Repair Operations and Annuloplasty Rings for Primary Mitral Valve RegurgitationNIHNational Heart, Lung, and Blood Institute2021 to 2022$144,400July 1, 2021June 30, 2023ZHU, YUANJIAreporter.nih.gov
Dynamic Modeling of Mechanotransduction in the Bicuspid Aortic Valve: Separating the Effects of Altered VICs and MechanicsNIHNational Heart, Lung, and Blood Institute2021 to 2022$144,400September 1, 2020August 31, 2023HOWSMON, DANIEL PAULreporter.nih.gov
Defining the downstream genetic networks regulated by GATA6 during human cardiogenesis using iPSC and hESC modelsNIHNational Heart, Lung, and Blood Institute2021 to 2022$144,400June 1, 2020May 31, 2023BISSON, JOSEPH Areporter.nih.gov
Circadian Regulation of Cardiomyocyte Size and FunctionNIHNational Heart, Lung, and Blood Institute2025$143,829January 1, 2025December 31, 2029BLAIR, CHEAVARreporter.nih.gov
Quantitative Magnetic Resonance Properties of Cerebrospinal Fluid and Brain Health Outcomes in Pediatric Congenital Heart DiseaseNIHNational Heart, Lung, and Blood Institute2022 to 2024$143,420September 1, 2022August 31, 2025LEE, VINCENT KYUreporter.nih.gov
Dual-Venc 5D flow for Assessment of Congenital Heart Disease in PediatricsNIHNational Heart, Lung, and Blood Institute2023 to 2025$142,680July 1, 2023August 31, 2026WEISS, ELIZABETHreporter.nih.gov
Cardiac 1H MRS assessment of NAD+ after Tetralogy of Fallot repairNIHNational Heart, Lung, and Blood Institute2021 to 2023$140,482September 1, 2021August 31, 2024SWAGO, SOPHIAreporter.nih.gov
Regulation of cardiac chamber morphology in zebrafishNIHNational Heart, Lung, and Blood Institute2021 to 2022$140,296August 1, 2020July 31, 2023LEERBERG, DENA MARIEreporter.nih.gov
Genetic dissection of fluid flow signaling in Left-Right patterning of zebrafishNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2022 to 2024$140,191July 1, 2022June 30, 2025FISHER, KATHERINE Hreporter.nih.gov
Targeting Mek/Erk Signaling in the Treatment of Mitral Valve ProlapseNIHNational Heart, Lung, and Blood Institute2021 to 2023$139,580July 1, 2021June 30, 2024BECK, TYLERreporter.nih.gov
Brain Abnormalities and Neurobehavioral Deficits in Hypoplastic Left Heart SyndromeNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2021 to 2023$136,994May 17, 2019October 16, 2023GABRIEL, GEORGE CHRISTOPHERreporter.nih.gov
Defining the Cellular Morphogenic Behaviors that Shape the Developing HeartNIHNational Heart, Lung, and Blood Institute2022 to 2023$136,674January 1, 2022December 31, 2023MUNCIE-VASIC, JONATHON MICHAELreporter.nih.gov
Functional and molecular mechanisms of human calmodulinopathy in cardiac arrhythmias and sudden cardiac deathNIHNational Heart, Lung, and Blood Institute2021 to 2022$136,192September 30, 2020September 29, 2023WOLTZ, RYAN LEEreporter.nih.gov
Uncovering the Mechanisms that Enable Cardiac Progenitors to Build the Linear Heart TubeNIHNational Heart, Lung, and Blood Institute2025$134,998July 20, 2025May 31, 2027MUNCIE-VASIC, JONATHON MICHAELreporter.nih.gov
Embryologic Origins of Aortopathy: Biomechanical Characterization of Aortic Aneurysms in the NOTCH1 Mutant ModelNIHNational Heart, Lung, and Blood Institute2021 to 2022$133,801September 1, 2021June 30, 2023ACKAH, RUTHreporter.nih.gov
Use of Predictive Analytics to Quantify Neonatal Hypothermia Burden After Cardiac SurgeryNIHNational Institute of Nursing Research2021 to 2023$133,652July 1, 2021December 31, 2023HELMAN, STEPHANIE Mreporter.nih.gov
Improving mutant KV11.1 trafficking to treat Long QT SyndromeNIHNational Heart, Lung, and Blood Institute2025$131,571September 1, 2025August 31, 2030EGLY, CHRISTIAN Lreporter.nih.gov
Ontogeny and Genetics of NSAID Dose-Exposure Relationship in Preterm InfantsNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2021$129,022September 25, 2018December 31, 2021LEWIS, TAMORAH Rreporter.nih.gov
4D Virtual Catheter (vCath) Assessment of Hemodynamic Pathways in Aortopathy PathogenesisNIHNational Heart, Lung, and Blood Institute2021$119,125February 1, 2020January 31, 2024ELBAZ, MOHAMMEDreporter.nih.gov
Retinoic acid-dependent mechanisms patterning the cardiac progenitor fieldsNIHNational Heart, Lung, and Blood Institute2021 to 2023$111,191March 1, 2021December 8, 2023DUONG, TIFFANYreporter.nih.gov
Investigation of Chromatin Modifiers to Elucidate the Phenotypic Variability of Congenital Heart Disease in Patients with 22q11.2 Deletion SyndromeNIHNational Heart, Lung, and Blood Institute2024 to 2025$108,512January 16, 2024July 15, 2027MILLER, DANIELLAreporter.nih.gov

Organizations

OrganizationPlaceNIH awardsNIH amountNSF awardsNSF amount
Cincinnati Childrens Hosp Med CTRCincinnati, OH15$37.2 million0$0
Boston Children's HospitalBoston, MA33$35.6 million0$0
Research Inst Nationwide Children's HospColumbus, OH22$28.6 million0$0
University of HawaiiHonolulu, HI1$25.5 million0$0
University of California, San FranciscoSan Francisco, CA14$22.5 million0$0
Stanford UniversityStanford, CA19$19.9 million0$0
Yale UniversityNew Haven, CT21$18.3 million0$0
J. David Gladstone InstitutesSan Francisco, CA9$17 million0$0
Icahn School of Medicine at Mount SinaiNew York, NY10$16.3 million0$0
University of California, San DiegoLa Jolla, CA12$16.2 million0$0
Columbia University Health SciencesNew York, NY17$15.3 million0$0
University of Pittsburgh at PittsburghPittsburgh, PA17$15.2 million0$0
Vanderbilt University Medical CenterNashville, TN11$14.7 million0$0
University of Colorado DenverAurora, CO15$13.5 million0$0
University of Maryland BaltimoreBaltimore, MD7$13.4 million0$0
Children's Research InstituteWashington, DC10$12.9 million0$0
University of California Los AngelesLos Angeles, CA12$12.3 million0$0
University of UtahSalt Lake City, UT6$12.2 million0$0
Massachusetts General HospitalBoston, MA5$12 million0$0
Albert Einstein College of MedicineBronx, NY7$11.1 million0$0
Northwestern University at ChicagoChicago, IL11$10.4 million0$0
Medical University of South CarolinaCharleston, SC9$10.2 million0$0
Indiana University IndianapolisIndianapolis, IN4$9.5 million0$0
Emory UniversityAtlanta, GA13$9.1 million0$0
Mayo Clinic RochesterRochester, MN5$8.4 million0$0
University of WashingtonSeattle, WA5$7.4 million0$0
Baylor College of MedicineHouston, TX9$7.1 million0$0
Children's Hosp of PhiladelphiaPhiladelphia, PA6$7.1 million0$0
Oregon Health & Science UniversityPortland, OR5$7 million0$0
Case Western Reserve UniversityCleveland, OH3$6.9 million0$0
Starlight Cardiovascular, Inc.San Diego, CA5$6.7 million0$0
Washington UniversitySaint Louis, MO9$6.2 million0$0
Duke UniversityDurham, NC6$6.1 million0$0
University of Wisconsin-MadisonMadison, WI5$6 million0$0
Johns Hopkins UniversityBaltimore, MD4$5.8 million0$0
Univ of North Carolina Chapel HillChapel Hill, NC4$5.8 million0$0
University of ChicagoChicago, IL7$5.4 million0$0
Vanderbilt UniversityNashville, TN8$4.8 million0$0
University of PennsylvaniaPhiladelphia, PA6$4.6 million0$0
University of IowaIowa City, IA5$4.6 million0$0
University of Michigan at Ann ArborAnn Arbor, MI5$4.4 million0$0
Lurie Children's Hospital of ChicagoChicago, IL4$4.4 million0$0
University of ArizonaTucson, AZ2$4.3 million0$0
Cedars-Sinai Medical CenterLos Angeles, CA5$4.3 million0$0
Weill Medical Coll of Cornell UnivNew York, NY4$4.3 million0$0
University of Texas HLTH Sci CTR HoustonHouston, TX4$4.2 million0$0
Ohio State UniversityColumbus, OH6$4.1 million0$0
Annoviant, INCAlpharetta, GA1$4 million0$0
University of Miami School of MedicineCoral Gables, FL2$3.8 million0$0
University of California at DavisDavis, CA3$3.7 million0$0
Medical College of WisconsinMilwaukee, WI6$3.6 million0$0
Texas A&m University Health Science CTRCollege Station, TX2$3.6 million0$0
Ut Southwestern Medical CenterDallas, TX4$3.5 million0$0
University of HoustonHouston, TX2$3.4 million0$0
Sanford Burnham Prebys Medical Discovery InstituteLa Jolla, CA1$3.3 million0$0
Rutgers Biomedical and Health SciencesNewark, NJ5$3.3 million0$0
Polyvascular INCHouston, TX1$3.2 million0$0
Children's Hospital of Los AngelesLos Angeles, CA4$3.2 million0$0
Cornell UniversityIthaca, NY1$3.1 million0$0
University of Calif-Lawrenc Berkeley LabBerkeley, CA1$3 million0$0
Omniox, Inc.San Francisco, CA1$3 million0$0
Methodist Hospital Research InstituteHouston, TX1$3 million0$0
New York UniversityNew York, NY2$2.9 million0$0
Harvard Medical SchoolBoston, MA2$2.9 million0$0
Texas Heart InstituteHouston, TX2$2.8 million0$0
Transmural Systems, LLCAndover, MA1$2.5 million0$0
University of South Carolina at ColumbiaColumbia, SC2$2.4 million0$0
Research Triangle InstituteResearch Triangle Park, NC1$2.4 million0$0
University of VirginiaCharlottesville, VA2$2.3 million0$0
University of California-IrvineIrvine, CA4$2.3 million0$0
Narrows Institute for Biomedical Res INCBrooklyn, NY1$2.3 million0$0
George Washington UniversityWashington, DC2$2.3 million0$0
Michigan State UniversityEast Lansing, MI1$2.2 million0$0
Brigham and Women's HospitalBoston, MA3$2.1 million0$0
University of South FloridaTampa, FL2$2.1 million0$0
California Institute of TechnologyPasadena, CA2$1.9 million0$0
University of Illinois at ChicagoChicago, IL1$1.9 million0$0
University of Missouri-ColumbiaColumbia, MO1$1.9 million0$0
Rensselaer Polytechnic InstituteTroy, NY1$1.8 million0$0
Heartpoint Global INCCoral Gables, FL1$1.8 million0$0
Khloris Biosciences, Inc.South San Francisco, CA1$1.7 million0$0
Onocor, LLCPhiladelphia, PA1$1.7 million0$0
Rhode Island HospitalProvidence, RI1$1.6 million0$0
University of Alabama at BirminghamBirmingham, AL3$1.5 million0$0
SUNY at Stony BrookStony Brook, NY1$1.5 million0$0
Institute for Basic Res in Dev DisabilStaten Island, NY1$1.4 million0$0
Children's Mercy Hosp (kansas City, Mo)Kansas City, MO3$1.4 million0$0
University of TX MD Anderson Can CTRHouston, TX1$1.4 million0$0
Harvard UniversityCambridge, MA1$1.4 million0$0
Loyola University ChicagoMaywood, IL1$1.3 million0$0
Rbhs-New Jersey Medical SchoolNewark, NJ5$1.3 million0$0
Ihc Health Services, Inc.Salt Lake City, UT1$1.2 million0$0
University of FloridaGainesville, FL4$1.2 million0$0
Wake Forest University Health SciencesWinston-Salem, NC1$1.2 million0$0
University of Texas at AustinAustin, TX4$1.1 million0$0
Upstate Medical UniversitySyracuse, NY2$1.1 million0$0
University of Connecticut SCH of Med/dntFarmington, CT1$1 million0$0
University of RochesterRochester, NY1$1 million0$0
Elex Biotech, LLCPortland, OR1$971,3230$0
Kennesaw State UniversityKennesaw, GA2$948,2670$0

Funding by fiscal year

Fiscal yearNIH awardsNIH amountNSF awardsNSF amount
2025262$131,831,3010$0
2024282$145,214,7170$0
2023265$136,974,0400$0
2022275$135,451,7030$0
2021264$126,823,3850$0

Open federal funding opportunities

From Grants.gov: notices that funded awards in this table, and open notices on the same agency and assistance listing.

Open opportunityNumberAgencyListingClosesAward ceilingWhy it matches
Change of Recipient Organization (Type 7 Parent Clinical Trial Optional)PA-24-254NIHJuly 12, 2027Not listedNotice number printed on 4 awards here
NIH Pathway to Independence Award (Parent K99/R00 Independent Clinical Trial Not Allowed)PA-24-194NIHMay 7, 2027Not listedNotice number printed on 1 award here
Mentored Clinical Scientist Research Career Development Award (Parent K08 Independent Clinical Trial Not Allowed)PA-24-182NIHMay 8, 2027Not listedNotice number printed on 1 award here
Emerging Global Leader Award (K43 Independent Clinical Trial Required)PAR-24-295NIH93.837December 3, 2026Not listedSame assistance listing 93.837 as 460 awards here
Emerging Global Leader Award (K43 Independent Clinical Trial Not Allowed)PAR-24-296NIH93.837December 3, 2026Not listedSame assistance listing 93.837 as 460 awards here
NIH Research Software Engineer (RSE) Award (R50 Clinical Trials Not Allowed)RFA-OD-24-011NIH93.837December 4, 2026Not listedSame assistance listing 93.837 as 460 awards here
Small Business Transition Grant for New Entrepreneurs (Parent R43/R44 Clinical Trial Optional)PAR-27-039NIH93.837January 5, 2027Not listedSame assistance listing 93.837 as 460 awards here
Small Business Transition Grant for New Entrepreneurs (Parent R41/R42 Clinical Trial Optional)PAR-27-040NIH93.837January 5, 2027Not listedSame assistance listing 93.837 as 460 awards here
Academic Research Enhancement Award (AREA) for Undergraduate-Focused Institutions (R15 Clinical Trial Required)PAR-24-214NIH93.837January 7, 2027$375,000Same assistance listing 93.837 as 460 awards here
Intervention Research to Improve Native American Health (R01 Clinical Trial Optional)PAR-25-379NIH93.837January 7, 2027Not listedSame assistance listing 93.837 as 460 awards here
NHLBI Early Phase Clinical Trials for Therapeutics and/or Diagnostics for HLBS Disorders (R33 CT Required)PAR-25-025NIH93.837February 3, 2027$1.5 millionSame assistance listing 93.837 as 460 awards here
NHLBI Early Phase Clinical Trials for Therapeutics and/or Diagnostics for HLBS Disorders (R61/R33 Clinical Trial Required)PAR-25-026NIH93.837February 3, 2027Not listedSame assistance listing 93.837 as 460 awards here
Multi-Site Investigator-Initiated Clinical Trials (Collaborative UG3/UH3 Clinical Trial Required)PAR-27-125NIH93.837February 16, 2027Not listedSame assistance listing 93.837 as 460 awards here
Continuation of the Cardiovascular Repository for-Type 1 Diabetes (CARE-T1D) Consortium U01 (Open Competition)- Research (U01, Clinical Trial Not Allowed)RFA-DK-27-108NIH93.837March 10, 2027$500,000Same assistance listing 93.837 as 460 awards here
NHLBI Clinical Trial Pilot Studies (R34 Clinical Trial Optional)PAR-25-032NIH93.837March 16, 2027Not listedSame assistance listing 93.837 as 460 awards here
NIH, CDC and FDA Small Business Innovation Research Grant (Parent SBIR [R43/R44] Clinical Trial Optional)PA-27-100NIH93.837April 5, 2027Not listedSame assistance listing 93.837 as 460 awards here
NIH Small Business Technology Transfer Grant (Parent STTR [R41/R42] Clinical Trial Optional)PA-27-102NIH93.837April 5, 2027Not listedSame assistance listing 93.837 as 460 awards here
Short Courses on Innovative Methodologies and Approaches in the Behavioral and Social Sciences (R25 Clinical Trials Not Allowed)RFA-OD-25-003NIH93.837April 9, 2027$200,000Same assistance listing 93.837 as 460 awards here
NHLBI Outstanding Investigator Award (OIA) (R35 Clinical Trial Optional)RFA-HL-26-002NIH93.837April 28, 2027Not listedSame assistance listing 93.837 as 460 awards here
NHLBI Emerging Investigator Award (EIA) (R35 Clinical Trial Optional)RFA-HL-26-003NIH93.837April 28, 2027Not listedSame assistance listing 93.837 as 460 awards here

Updated November 3, 2026. Read from NIH RePORTER ExPORTER and NSF Award Search. Published by NIH and NSF as U.S. government data. NIH awards are fiscal years 2021 to 2025 (NIH files published to 2026-07-09); NSF awards are fiscal years 2022 to 2026 (NSF files published to 2026-11-02). NIH amounts are the total cost of each fiscal year in the window; NSF amounts are the funds obligated in the window. Organizations are matched on the UEI. Open opportunities come from Grants.gov and match on agency and assistance listing number, and on the notice number NIH prints on an award. Free to reuse with credit to SpecStream under CC BY 4.0. Spot a wrong value? Write to [email protected] with the link to this page.