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Data / Research funding / Cerebrovascular

Cerebrovascular: 3,265 NIH awards ($5.1B) to 432 organizations

3,265 NIH awards ($5.1B) in the NIH spending category Cerebrovascular, to 432 organizations, read 2026-11-04. NIH fiscal years 2021 to 2025.

SpecStream is the live web data engine for teams and agents. It reads the NIH and NSF award files each time the agencies update them, and this page is that reading, joined to the open federal funding opportunities on Grants.gov. Ask for the awards you track by topic, organization or state and new awards arrive in your sheet, CRM, Slack or agent as the agencies publish them.

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NIH spending category

Awards

The 500 largest of 3,265 awards in the window.

AwardAgencyInstitute or divisionFiscal yearAmount in windowStartEndPrincipal investigatorSource
Alzheimer's Disease Neuroimaging Initiative (ADNI4)NIHNational Institute on Aging2022 to 2025$95,332,786September 30, 2004July 31, 2028WEINER, MICHAEL Wreporter.nih.gov
Alzheimer's Disease and Alzheimer's Disease Related Dementias in Prediabetes and Type 2 Diabetes: The Diabetes Prevention Program Outcomes Study AD/ADRD ProjectNIHNational Institute on Aging2022 to 2025$66,521,567September 1, 2022August 31, 2027LUCHSINGER, JOSE ALEJANDROreporter.nih.gov
ADRC Consortium for Clarity in ADRD Research Through ImagingNIHNational Institute on Aging2023 to 2024$60,357,563September 15, 2023August 31, 2028JOHNSON, STERLING Creporter.nih.gov
Alzheimer's Disease Sequencing Project Phenotype Harmonization ConsortiumNIHNational Institute on Aging2021 to 2025$37,497,984September 30, 2021August 31, 2026HOHMAN, TIMOTHY Jreporter.nih.gov
Cognitive training to reduce incidence of cognitive impairment in older adultsNIHNational Institute on Aging2021 to 2024$37,326,564February 1, 2021January 31, 2027O'BRIEN, JENNIFER LEEreporter.nih.gov
The Emory Healthy Brain Study: Discovering Predictive Biomarkers for Alzheimer's DiseaseNIHNational Institute on Aging2021 to 2025$35,158,235February 15, 2021January 31, 2027LAH, JAMES Jreporter.nih.gov
Comparison of Anti-coagulation and anti-Platelet Therapies for Intracranial Vascular AtherostenosisNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$26,536,563September 1, 2021May 31, 2028HOH, BRIAN LIMreporter.nih.gov
BPN-MCSP-HIT TO LEAD CHEMISTRY- MARTIN (NUVONURO)NIHNational Institute on Drug Abuse2021 to 2025$25,707,343December 9, 2024June 8, 2026MICHELS, PETER Creporter.nih.gov
US POINTER Neuroimaging Ancillary StudyNIHNational Institute on Aging2021 to 2025$24,762,483August 1, 2019March 31, 2027LANDAU, SUSAN Mreporter.nih.gov
Metformin in Alzheimer's dementia Prevention (MAP)NIHNational Institute on Aging2021 to 2025$24,224,790August 15, 2019April 30, 2027LUCHSINGER, JOSE ALEJANDROreporter.nih.gov
Wisconsin Registry for Alzheimer's PreventionNIHNational Institute on Aging2023 to 2025$21,491,270June 1, 2023February 29, 2028JOHNSON, STERLING Creporter.nih.gov
Unraveling the earliest phases of vascular cognitive impairment and dementia using CADASIL--a monogenic form of small vessel cerebrovascular diseaseNIHNational Institute on Aging2021 to 2025$21,188,740September 30, 2021August 31, 2027PAULSEN, JANE Sreporter.nih.gov
Epidemiology of Age-related Dementia, Mild Cognitive Impairment and Brain Pathology in Cohort of Oldest-OldNIHNational Institute on Aging2022 to 2025$20,680,832September 15, 2017June 30, 2027WHITMER, RACHEL Areporter.nih.gov
Lifecourse health, cerebral pathology and differences in dementia risk (KHANDLE Study)NIHNational Institute on Aging2021 to 2025$18,022,067June 1, 2016February 28, 2027WHITMER, RACHEL Areporter.nih.gov
Study of Latinos-Investigation of Neurocognitive Aging-Alzheimer's diseaseNIHNational Institute on Aging2022 to 2025$17,997,906May 15, 2022January 31, 2028GONZALEZ, HECTOR Mreporter.nih.gov
Subclinical Vascular Contributions to Alzheimer's Disease: The Multi-Ethnic Study of Atherosclerosis (MESA) Multisite Study of AD (Renewal)NIHNational Institute on Aging2021 to 2025$17,112,209August 15, 2018May 31, 2029HUGHES, TIMOTHY M.reporter.nih.gov
Offspring Study of Mechanisms for Racial Disparities in Alzheimer's DiseaseNIHNational Institute on Aging2021 to 2025$17,095,138September 1, 2016May 31, 2027MANLY, JENNIFER JAIEreporter.nih.gov
Strategies for targeting astrocyte reactivity in Alzheimer's disease and related dementiasNIHNational Institute on Aging2022 to 2025$17,073,728September 1, 2022June 30, 2027NORRIS, CHRISTOPHER MARKreporter.nih.gov
Biomarkers of Cognitive Decline Among Normal Individuals: The Biocard CohortNIHNational Institute on Aging2021 to 2025$16,952,609July 1, 2009May 31, 2027ALBERT, MARILYN S.reporter.nih.gov
Diabetes and brain amyloid in middle aged HispanicsNIHNational Institute on Aging2021 to 2025$16,383,484September 1, 2015May 31, 2027LUCHSINGER, JOSE ALEJANDROreporter.nih.gov
Understanding Cohort Effects on Stroke, VCID, and Cognition After Major Epidemiologic TransitionsNIHNational Institute of Neurological Disorders and Stroke2024$16,244,011September 24, 2001August 31, 2026JUDD, SUZANNE Ereporter.nih.gov
Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial (CREST-2)NIHNational Institute of Neurological Disorders and Stroke2021 to 2025$16,136,344March 15, 2014August 31, 2026BROTT, THOMAS Greporter.nih.gov
ARIC Neurocognitive Study (ARIC-NCS) RenewalNIHNational Heart, Lung, and Blood Institute2021 to 2022$15,682,941July 7, 2010March 31, 2024CORESH, JOSEFreporter.nih.gov
The Rhythm Evaluation for Anticoagulation with Continuous Monitoring of Atrial Fibrillation Trial (REACT-AF)NIHNational Heart, Lung, and Blood Institute2023 to 2025$14,978,926August 25, 2022July 31, 2029PASSMAN, ROD Sreporter.nih.gov
Alzheimer's Disease Research CentersNIHNational Institute on Aging2021 to 2025$14,719,450September 1, 2020March 31, 2030CHUI, HELENA CHANGreporter.nih.gov
Integrative Pathways to Cognitive, Affective, and Brain HealthNIHNational Institute on Aging2022 to 2025$14,488,542September 30, 2022August 31, 2028RYFF, CAROL D.reporter.nih.gov
FVIIa for Acute hemorrhagic Stroke Administered at Earliest Time (FASTEST) TrialNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$14,427,244March 1, 2020December 31, 2026BRODERICK, JOSEPH PAULreporter.nih.gov
Mild Cognitive Impairment: A Prospective Community StudyNIHNational Institute on Aging2021 to 2025$14,337,476September 1, 2005April 30, 2026GANGULI, MARYreporter.nih.gov
Study of Healthy Aging in African AmericansNIHNational Institute on Aging2023 to 2025$14,240,222January 1, 2017May 31, 2028WHITMER, RACHEL Areporter.nih.gov
MACS/WIHS Combined Cohort Study: Brooklyn Clinical Research Site (Bklyn CRS)NIHNational Heart, Lung, and Blood Institute2021 to 2025$14,117,524April 1, 2019September 30, 2026GUSTAFSON, DEBORAH R.reporter.nih.gov
Vanderbilt Memory & Aging ProjectNIHNational Institute on Aging2021 to 2025$14,019,775March 15, 2011March 31, 2027JEFFERSON, ANGELA L.reporter.nih.gov
Sleep for Stroke Management And Recovery Trial (Sleep SMART)NIHNational Institute of Neurological Disorders and Stroke2024 to 2025$13,933,376August 15, 2018April 30, 2027BROWN, DEVIN Lreporter.nih.gov
Center for the Study of Aphasia Recovery (C-STAR)NIHNational Institute on Deafness and Other Communication Disorders2021 to 2025$13,541,079April 1, 2016March 31, 2027FRIDRIKSSON, JULIUSreporter.nih.gov
Epidemiological and Genetic Investigations of Blood-Based Biomarkers for Alzheimer's Disease in the Multiethnic, Washington Heights, Inwood, Columbia Aging Project (WHICAP)NIHNational Institute on Aging2021 to 2025$13,310,071June 1, 2021March 31, 2027MAYEUX, RICHARD Preporter.nih.gov
ARIC Neurocognitive Study (ARIC-NCS) Renewal 2023-2028NIHNational Heart, Lung, and Blood Institute2024 to 2025$13,305,831July 7, 2010March 31, 2029CORESH, JOSEFreporter.nih.gov
MIND DIET AND DEMENTIA PREVENTION IN ISCHEMIC STROKE PATIENTSNIHNational Institute on Aging2021 to 2025$13,186,351September 1, 2020May 31, 2027AGGARWAL, NEELUM T.reporter.nih.gov
Testing Hypothesized Pathways Linking Infection, Physical Activity, Apoe Genotype, And Biological Sex To Low Dementia Prevalence And Reduced Brain Atrophy In Two Native American PopulationsNIHNational Institute on Aging2022 to 2025$12,690,286April 15, 2017April 30, 2027KAPLAN, HILLARD Sreporter.nih.gov
Exploring Cognitive Aging Using Reference Ability Neural NetworksNIHNational Institute on Aging2021 to 2025$12,167,937September 1, 2011June 30, 2027STERN, YAAKOVreporter.nih.gov
StrokeNet Thrombectomy Endovascular Platform (STEP)NIHNational Institute of Neurological Disorders and Stroke2022 to 2025$12,112,868September 1, 2022February 28, 2026ELM, JORDAN J.reporter.nih.gov
Alzheimers Disease Patient Registry (Administrative Supplement)NIHNational Institute on Aging2021 to 2023$11,991,901September 30, 1986June 30, 2026PETERSEN, RONALD Creporter.nih.gov
I3C DECADE: Developmental Epidemiology of Childhood Cardiovascular Exposures and Alzheimer’s DementiaNIHNational Institute on Aging2022 to 2025$11,889,015July 1, 2022April 30, 2028MACLEHOSE, RICHARD Freporter.nih.gov
West Virginia University Stroke COBRENIHNational Institute of General Medical Sciences2021 to 2024$11,604,264September 8, 2014May 31, 2026DEVRIES, ANNE COURTNEYreporter.nih.gov
Estrogens, Cardiometabolic Health, and Female Cognitive AgingNIHNational Institute on Aging2022 to 2025$11,521,268March 1, 2022February 28, 2027DANIEL, JILL Mreporter.nih.gov
Sleep in Neurocognitive Aging and Alzheimers Research (SANAR)NIHNational Institute on Aging2021 to 2025$11,494,462February 1, 2021January 31, 2027RAMOS, ALBERTO RAFAELreporter.nih.gov
Impact of Neuroinflammation on AD Occurrence: A Bi-Generational Population StudyNIHNational Institute on Aging2021 to 2025$11,418,675September 1, 2021May 31, 2027RAJAN, KUMAR B.reporter.nih.gov
Racial Differences in Late-Life Cognitive decline and risk of Alzheimer's DiseaseNIHNational Institute on Aging2021 to 2025$11,402,108September 30, 2004May 31, 2027BARNES, LISA Lreporter.nih.gov
Complement Mediated Remodeling in Pulmonary Vascular DiseaseNIHNational Heart, Lung, and Blood Institute2021 to 2024$11,355,302August 1, 2020June 30, 2026STENMARK, KURT R.reporter.nih.gov
VCID Biomarkers Coordinating CenterNIHNational Institute of Neurological Disorders and Stroke2022 to 2025$10,493,954September 30, 2016June 30, 2027GREENBERG, STEVEN Mreporter.nih.gov
NIH StrokeNet National Clinical Coordinating Center (NCC)NIHNational Institute of Neurological Disorders and Stroke2021 to 2025$10,366,158September 30, 2013November 30, 2028BRODERICK, JOSEPH PAULreporter.nih.gov
Validation of Early Prognostic Data for Recovery Outcomes after Stroke for Future, Higher Yield Trials (VERIFY)NIHNational Institute of Neurological Disorders and Stroke2021 to 2025$10,302,336September 1, 2021July 1, 2025KHATRI, POOJAreporter.nih.gov
Vermont Center for Cardiovascular and Brain HealthNIHNational Institute of General Medical Sciences2021 to 2024$10,185,844August 6, 2020May 31, 2026CUSHMAN, MARYreporter.nih.gov
StATins Use in intRacerebral hemorrhage patieNts (SATURN)NIHNational Institute of Neurological Disorders and Stroke2021 to 2025$10,035,219September 1, 2019February 29, 2028SELIM, MAGDY Hreporter.nih.gov
Longitudinal Relationships Among Sleep, Cognition and Alzheimer's Disease Biomarkers: Discerning Causal Associations, Mediators and SusceptibilityNIHNational Institute on Aging2021 to 2024$9,901,034May 1, 2021February 28, 2026REDLINE, SUSAN S.reporter.nih.gov
Sickle Cell Disease and Cardiovascular Risk- Red Cell Exchange SCD-CARRENIHNational Heart, Lung, and Blood Institute2022 to 2025$9,739,425September 1, 2022April 30, 2027GLADWIN, MARK Treporter.nih.gov
Impact of Intensive Treatment of Systolic Blood Pressure on Brain Perfusion, Amyloid and Tau in Older Adults (IPAT-study)NIHNational Institute on Aging2022 to 2025$9,488,371August 1, 2022July 31, 2027ZHANG, RONGreporter.nih.gov
BEACH: Biomarker and Edema Attenuation in IntraCerebral Hemorrhage Phase 2a TrialNIHNational Institute on Aging2021 to 2025$9,481,336February 15, 2021November 30, 2026HANLEY, DANIEL Freporter.nih.gov
Perinatal Arterial Stroke: A Multi-site RCT of Intensive Infant Rehabilitation (I-ACQUIRE)NIHNational Institute of Neurological Disorders and Stroke2021 to 2024$9,464,743February 1, 2019January 31, 2026RAMEY, SHARON LANDESMANreporter.nih.gov
The San Antonio Heart and Mind StudyNIHNational Institute on Aging2023 to 2025$9,286,743July 1, 2023March 31, 2029SATIZABAL, CLAUDIA Lreporter.nih.gov
African Americans Fighting Alzheimer’s in Midlife (AA-FAIM)NIHNational Institute on Aging2021 to 2025$9,250,399August 1, 2016November 30, 2027GLEASON, CAREY Ereporter.nih.gov
Assessing the role of cerebrovascular brain injury and dysfunction in Alzheimer’s disease pathogenesis in the BEACoN CohortNIHNational Institute on Aging2021 to 2025$9,240,061August 1, 2017December 31, 2027YASSA, MICHAEL Areporter.nih.gov
Anticoagulation in ICH Survivors for Prevention and Recovery (ASPIRE)NIHNational Institute of Neurological Disorders and Stroke2023 to 2024$9,111,057July 1, 2019April 30, 2027SHETH, KEVIN NAVINreporter.nih.gov
Investigating the Functional Impact of AD Risk Genes on Neuro-Vascular InteractionsNIHNational Institute on Aging2021 to 2025$8,654,669July 1, 2021June 30, 2027TEMPLE, SALLYreporter.nih.gov
P-CARRS-BRAIN: Multi-domain (genetic, socio-behavioral, vascular) risk factors and prediction of Alzheimer’s Disease continuum in South Asians in IndiaNIHNational Institute on Aging2024 to 2025$8,548,820September 15, 2024August 31, 2029NARAYAN, KABAYAM M VENKATreporter.nih.gov
REasons for Geographic And Racial Differences in Stroke-Myocardial Infarction-4 (REGARDS-MI-4)NIHNational Heart, Lung, and Blood Institute2022 to 2025$8,345,645September 10, 2022July 31, 2027SAFFORD, MONIKA Mreporter.nih.gov
COBRE in Stroke Recovery Administrative Supplement - Team ScienceNIHNational Institute of General Medical Sciences2021 to 2024$8,212,817June 2, 2014March 31, 2025KAUTZ, STEVEN A.reporter.nih.gov
Race / Ethncicity, Hypertension and Prevention of VCID and Stroke after Intracerebral HemmorrhageNIHNational Institute of Neurological Disorders and Stroke2022 to 2025$8,210,604February 1, 2016July 31, 2027ROSAND, JONATHANreporter.nih.gov
THE NIH PRECISION BRAIN HEALTH NETWORK: Open and Inclusive Measurement of Neuropsychological Change for AD/ADRD Primary Prevention TrialsNIHNational Institute on Aging2025$7,948,867August 1, 2025July 31, 2030SLIWINSKI, MARTIN Jreporter.nih.gov
ERICH-GENENIHNational Institute of Neurological Disorders and Stroke2021 to 2024$7,768,356August 1, 2010June 30, 2025DEMEL, STACIEreporter.nih.gov
The POINTER Neurovascular Ancillary StudyNIHNational Institute on Aging2021 to 2024$7,761,498April 15, 2020December 31, 2025BRINKLEY, TINA Ereporter.nih.gov
SCAN: Standardized Centralized Alzheimer's and Related Dementias NeuroimagingNIHNational Institute on Aging2021 to 2025$7,600,838May 1, 2020April 30, 2027JAGUST, WILLIAM J.reporter.nih.gov
Vietnamese Insights into Cognitive Aging Program (VIP)NIHNational Institute on Aging2021 to 2025$7,598,841February 15, 2021May 31, 2026MEYER, OANH Lreporter.nih.gov
Look AHEAD Sleep: Sleep-disordered breathing, circadian rest/activity rhythms, and the risk of Alzheimer's disease and related dementias in Look AHEADNIHNational Institute on Aging2021 to 2025$7,592,411August 15, 2021May 31, 2027UDEH-MOMOH, CHINEDU THERESAreporter.nih.gov
A major contributor of serious multisystem disease in the elderly: varicella zoster virus-induced inflammationNIHNational Institute on Aging2021 to 2023$7,526,233March 1, 2009December 31, 2025NAGEL, MARIA ACENAreporter.nih.gov
REpeated ASseSsmEnt of SurvivorS in ICH (REASSESS ICH)NIHNational Institute of Neurological Disorders and Stroke2022 to 2025$7,516,765January 1, 2022December 31, 2027ZIAI, WENDY Creporter.nih.gov
Multidimensional Assessment of Brain Health as A Marker of Dementia Risk and ResilienceNIHNational Institute on Aging2021 to 2024$7,413,273September 15, 2020May 31, 2025SESHADRI, SUDHAreporter.nih.gov
CYCLE-AD: Randomized Controlled Trial to Assess the Efficacy of Indoor Cycling in Slowing Disease Progression in Healthy Older Persons at Genetic Risk for Alzheimer’s DiseaseNIHNational Institute on Aging2021 to 2025$7,389,501January 15, 2021December 31, 2026RAO, STEPHEN MARKreporter.nih.gov
Predictors of Altered CNS Structure, Function, and Connectomics in the Elderly using a Health Disparities FrameworkNIHNational Institute on Aging2022 to 2025$7,350,257February 15, 2022November 30, 2027COHEN, ANN D.reporter.nih.gov
Leveraging the 24-hour movement paradigm to preserve cognitive function and prevent Alzheimer's disease: The Multi-Ethnic Study of Atherosclerosis (MESA) 24H-ACT StudyNIHNational Institute on Aging2021 to 2024$7,263,372May 1, 2021April 30, 2026DIAZ, KEITH Mreporter.nih.gov
The VETSA Longitudinal MRI Twin Study of Aging (VETSA MRI 4)NIHNational Institute on Aging2022 to 2025$7,252,240June 1, 2022March 31, 2027ELMAN, JEREMY Areporter.nih.gov
Pterygopalatine Fossa (PPF) Block as an Opioid Sparing Treatment for AcuteHeadache in Aneurysmal Subarachnold HemorrhageNIHNational Institute of Neurological Disorders and Stroke2023 to 2024$7,048,922March 15, 2023February 28, 2027BUSL, KATHARINA MARIAreporter.nih.gov
Multi-arm Optimization of Stroke Thrombolysis (MOST) Stroke TrialNIHNational Institute of Neurological Disorders and Stroke2021$6,997,609May 1, 2021October 31, 2024ADEOYE, OPEOLU Mreporter.nih.gov
University of Maryland Claude D. Pepper Older Americans Independence Center (OAIC)NIHNational Institute on Aging2021 to 2025$6,970,364September 15, 2006June 30, 2027RYAN, ALICE S.reporter.nih.gov
Developing Novel Soluble Epoxide Hydrolase Inhibitors for the Treatment of Alzheimer's DiseaseNIHNational Institute on Aging2021 to 2024$6,621,893September 15, 2020May 31, 2026WANG, JINreporter.nih.gov
A Pragmatic Trial of the UCSF Brain Health Assessment for the Detection of Cognitive Impairment in Primary CareNIHNational Institute of Neurological Disorders and Stroke2022 to 2025$6,593,404September 15, 2022August 31, 2027POSSIN, KATHERINE LAURELreporter.nih.gov
The effects of Alzheimer's disease risk genes on metabolism and signaling across cell typesNIHNational Institute on Aging2022 to 2025$6,477,664September 19, 2022August 31, 2027FRAENKEL, ERNESTreporter.nih.gov
Extracranial Carotid Atherosclerosis Contributions to Cognitive Impairment and Alzheimer's Disease RiskNIHNational Institute on Aging2021 to 2025$6,475,434August 15, 2021May 31, 2027WEINKAUF, CRAIG Creporter.nih.gov
The biological underpinnings of Motoric Cognitive Risk syndrome: a multi-center studyNIHNational Institute on Aging2021 to 2024$6,442,962June 15, 2020March 31, 2025VERGHESE, JOEreporter.nih.gov
Moderation of Aging Trajectories of Cognition and Neuropathology by Diet Composition in Middle-aged Nonhuman PrimatesNIHNational Institute on Aging2025$6,424,607September 15, 2025September 14, 2029BAXTER, MARK Greporter.nih.gov
Contributions of stress reactivity to risk of Alzheimer's disease and related dementia's in a community-based cohortNIHNational Institute on Aging2021 to 2025$6,416,931September 30, 2021May 31, 2027KERSHAW, KIARRI Nreporter.nih.gov
Validation of the Remote Cognitive Aging and Alzheimer’s Disease REsearch (R-CARE) Toolbox for Diverse PopulationsNIHNational Institute on Aging2023 to 2025$6,381,700August 15, 2023May 31, 2028LIPTON, RICHARD B.reporter.nih.gov
Cerebral small vessel disease burden and racial disparity in vascular cognitive impairment and Alzheimer’s disease and its related dementiasNIHNational Institute on Aging2021 to 2025$6,336,090September 15, 2021May 31, 2027HYACINTH, HYACINTH IDUreporter.nih.gov
A Life Course Approach to Integrating Trauma and Cognitive Aging: A Cohort of 9/11 RespondersNIHNational Institute on Aging2021 to 2024$6,329,240May 15, 2015April 30, 2026CLOUSTON, SEANreporter.nih.gov
PhytoSERM Efficacy to Prevent Menopause Associated Decline in Brain Metabolism and Cognition: A Double-Blind, Randomized, Placebo-Controlled Phase 2 Clinical TrialNIHNational Institute on Aging2022 to 2025$6,295,083February 15, 2022January 31, 2027BRINTON, ROBERTA EILEENreporter.nih.gov
Single Cell Transcriptomics of the Cocaine Use Disorder in the Context of HIVNIHNational Institute on Drug Abuse2022 to 2025$6,266,450June 15, 2022March 31, 2027CHENG, CHRISTINEreporter.nih.gov
Validation of Biomarkers of Small Vessel Injury in VCIDNIHNational Institute of Neurological Disorders and Stroke2021 to 2023$6,258,167September 29, 2021July 31, 2026ROSENBERG, GARY ALLENreporter.nih.gov
Washington University University of Texas Southwestern VCID Consortium SiteNIHNational Institute of Neurological Disorders and Stroke2021 to 2023$6,224,729September 29, 2021July 31, 2026LEE, JIN-MOOreporter.nih.gov
IND Enabling Studies for a Novel Mas Receptor Agonist for Treatment of Cognitive Impairment in Patients at Risk for Alzheimer's Disease Related DementiaNIHNational Institute on Aging2021 to 2023$6,168,197April 15, 2020March 31, 2024HAY, MEREDITHreporter.nih.gov
The University of Kentucky MarkVCID Biomarker Validation Cohort: Development of a Toolbox to Advance VCID Interventional StudiesNIHNational Institute of Neurological Disorders and Stroke2021 to 2023$6,120,000September 29, 2021July 31, 2026JICHA, GREGORY Areporter.nih.gov
MarkVCID Validation in the General CommunityNIHNational Institute of Neurological Disorders and Stroke2021 to 2023$6,100,999September 23, 2021July 31, 2026PETERSEN, RONALD Creporter.nih.gov
Biomarker Evaluation in Young Onset Dementia from Diverse Populations (BEYONDD)NIHNational Institute on Aging2022$6,065,228September 15, 2022August 31, 2025BOXER, ADAM L.reporter.nih.gov
2/2 REACT-AF: Rhythm Evaluation for AntiCoagulaTion with Continuous Monitoring of Atrial FibrillationNIHNational Heart, Lung, and Blood Institute2022 to 2025$6,043,000August 25, 2022July 31, 2029HANLEY, DANIEL Freporter.nih.gov
VCID CWOW: Identifying Novel Targets to Treat Cerebral Amyloid AngiopathyNIHNational Institute of Neurological Disorders and Stroke2024$5,949,022September 18, 2024August 31, 2027HOWELL, GARETH Rreporter.nih.gov
URBAn Native Elders (URBANE): Risk and Protective Factors for Alzheimer's and Related DementiasNIHNational Institute on Aging2021 to 2024$5,941,036September 1, 2019May 31, 2026NELSON, LONNIE A.reporter.nih.gov
PNA5: A Novel Mas Receptor Agonist for Treatment of Cognitive Impairment in Patients at Risk for Vascular Dementia and Alzheimer's Disease Related Dementia: an FDA required Toxicology StudyNIHNational Institute on Aging2023 to 2025$5,906,221September 1, 2023August 31, 2027HAY, MEREDITHreporter.nih.gov
Comparison of Hemorrhagic & Ischemic Stroke Among Blacks and WhitesNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$5,858,736September 22, 1992June 30, 2026KISSELA, BRETT Mreporter.nih.gov
Examining Effects of Intensive BP Control on MCI/Dementia and Plasma Biomarker Trajectories by AD Pathology: Elucidating neuroprotective effects in the racially and ethnically diverse SPRINT trialNIHNational Institute on Aging2025$5,789,766September 30, 2025June 30, 2030BRESS, ADAM Preporter.nih.gov
VCID and Stroke in a Bi-racial National CohortNIHNational Institute of Neurological Disorders and Stroke2021 to 2022$5,761,773September 24, 2001September 16, 2024JUDD, SUZANNE Ereporter.nih.gov
Cilostazol for Prevention of Recurrent Stroke (CLARITY)NIHNational Institute of Neurological Disorders and Stroke2025$5,747,701August 13, 2025July 31, 2026LANSBERG, MAARTEN Greporter.nih.gov
Cerebral tau deposition and comorbid cerebrovascular disease across the Alzheimer's disease continuum in Mexican AmericansNIHNational Institute on Aging2024 to 2025$5,730,361August 15, 2024August 31, 2029HABES, MOHAMADreporter.nih.gov
PRECISE (PeRfusion imaging to identify postErior CIrculation candidateS for thrombectomy)NIHNational Institute of Neurological Disorders and Stroke2021 to 2025$5,703,463August 1, 2021April 30, 2027ALBERS, GREGORY Wreporter.nih.gov
Brain pathologies, reserve and cognition in aging and dementiaNIHNational Institute on Aging2022 to 2025$5,694,414March 1, 2009March 31, 2027TOMASZEWSKI-FARIAS, SARAH Ereporter.nih.gov
CREST-2 Statistical and Data Coordinating Center - SDCCNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$5,657,860March 15, 2014August 31, 2026EDWARDS, LLOYD Jreporter.nih.gov
DON in Pediatric Cerebral Malaria: A Phase I / II Dose-Escalation Safety StudyNIHNational Institute of Allergy and Infectious Diseases2021 to 2025$5,567,850June 1, 2025May 31, 2027POSTELS, DOUGLASreporter.nih.gov
Roles of Gray Matter Brain Aging and Small Vessel Disease in AD PathophysiologyNIHNational Institute on Aging2021$5,546,075March 1, 2005February 29, 2024AIZENSTEIN, HOWARD Jreporter.nih.gov
Alzheimer’s Disease Related Biomarkers following SARS-CoV-2 InfectionNIHNational Institute on Aging2022 to 2025$5,518,240June 15, 2022March 31, 2027WISNIEWSKI, THOMAS Mreporter.nih.gov
Reducing Disparities in Dementia and VCID Outcomes in a Multicultural Rural PopulationNIHNational Institute of Neurological Disorders and Stroke2021 to 2023$5,484,212March 6, 2020March 21, 2025GALVIN, JAMES Ereporter.nih.gov
Vascular-immune mechanisms of cerebral amyloid angiopathy and Alzheimer's pathologyNIHNational Institute of Neurological Disorders and Stroke2024$5,423,836September 19, 2024August 31, 2027YANG, ANDREW CHRISreporter.nih.gov
System Wide Operations for Rare Disorders (SWORD)NIHNational Institute of Neurological Disorders and Stroke2021 to 2023$5,227,397September 30, 2009June 30, 2025KIM, HELENreporter.nih.gov
Environmental Exposures and Brain HealthNIHNational Institute on Aging2025$5,164,012September 1, 2025August 31, 2029JAMES, PETERreporter.nih.gov
Microbial Impact on NeuroDegeneration in Alzheimer's Dementia: MIND-ADNIHNational Institute on Aging2021 to 2025$5,121,493September 30, 2021May 31, 2027SPIRA, ADAM PETERreporter.nih.gov
Strategy for Improving Stroke Treatment Response (SISTER) TrialNIHNational Institute of Neurological Disorders and Stroke2023$5,110,320July 1, 2023June 30, 2024KHATRI, POOJAreporter.nih.gov
A Precision Medicine Approach for the Study of Targetable Pathways in Vascular DementiaNIHNational Institute on Aging2022 to 2025$5,086,657February 1, 2022November 30, 2026GOATE, ALISON Mreporter.nih.gov
Study of Latinos Investigation of Neurocognitive Aging 2NIHNational Institute on Aging2021$5,055,467September 1, 2015April 30, 2023GONZALEZ, HECTOR Mreporter.nih.gov
Brain Health and Ethnic Disparities in ADRD Risk: The Case of Arab AmericansNIHNational Institute on Aging2021 to 2025$5,040,162April 1, 2021March 31, 2027ANTONUCCI, TONI CLAUDETTEreporter.nih.gov
Molecular Mechanisms of the Blood Brain Barrier Function and RegulationNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$5,016,204May 1, 2020April 30, 2028GU, CHENGHUAreporter.nih.gov
Multi-scale and multi-modality imaging of neuropathology in VCIDNIHNational Institute of Neurological Disorders and Stroke2023 to 2025$4,964,481September 22, 2023August 31, 2028GE, YULINreporter.nih.gov
Strategy for Improving Stroke Treatment Response (SISTER) TrialNIHNational Institute of Neurological Disorders and Stroke2025$4,963,344July 1, 2023June 30, 2028KHATRI, POOJAreporter.nih.gov
IND Enabling Studies for RASRx 1902, a novel Mas receptor agonist, for treatment of cognitive impairment in patients at risk for Alzheimer's disease.NIHNational Institute on Aging2021 to 2023$4,958,940May 1, 2020April 30, 2026RODGERS, KATHLEEN E.reporter.nih.gov
Characterizing Cognitive Decline in Late Life Depression: The ADNI-D ProjectNIHNational Institute of Mental Health2022 to 2025$4,842,533August 1, 2013May 31, 2027MACKIN, ROBERT SCOTTreporter.nih.gov
Vasculo-neuronal pathophysiological interface in Alzheimer’s and AtherosclerosisNIHNational Institute of Neurological Disorders and Stroke2024$4,815,513September 18, 2024August 31, 2027IRUELA-ARISPE, M. LUISAreporter.nih.gov
Stroke Trials Network National Data Management Center (NDMC)NIHNational Institute of Neurological Disorders and Stroke2021 to 2025$4,796,926April 1, 2014November 30, 2028ELM, JORDAN J.reporter.nih.gov
Novel retinal higher-order capillary hemodynamics imaging for detecting cerebral small vessel diseaseNIHOffice of the Director, National Institutes of Health2024 to 2025$4,719,171September 15, 2024September 14, 2027WANG, JIANHUAreporter.nih.gov
Defining the molecular spectrum of white matter vascular lesionsNIHNational Institute of Neurological Disorders and Stroke2024$4,693,249September 17, 2024August 31, 2027HINMAN, JASON Dreporter.nih.gov
Spinal Cord Stimulation to Improve Motor Function in People with Post-Stroke HemiplegiaNIHNational Institute of Neurological Disorders and Stroke2022 to 2024$4,671,700September 8, 2022August 31, 2025CAPOGROSSO, MARCOreporter.nih.gov
Brain fluid clearance and misfolded protein dynamics following traumatic brain injuryNIHNational Institute on Aging2023 to 2025$4,618,282September 30, 2023June 30, 2029BUTLER, TRACY A.reporter.nih.gov
A consortium effort to translate therapies for neurological diseases via an ex vivo organotypic platformNIHNational Center for Advancing Translational Sciences2021 to 2024$4,598,428July 1, 2021April 30, 2026HINGTGEN, SHAWNreporter.nih.gov
Model-based cerebrovascular markers extracted from hemodynamic data for diagnosing MCI or AD and predicting disease progression.NIHNational Institute on Aging2021 to 2022$4,594,525September 1, 2018May 31, 2025MARMARELIS, VASILIS Zreporter.nih.gov
Brain Attack Surveillance in Corpus Christi (BASIC) ProjectNIHNational Institute of Neurological Disorders and Stroke2021 to 2023$4,569,381September 1, 1999March 31, 2024LISABETH, LYNDA Dreporter.nih.gov
An Acquisition and Analysis Pipeline for Integrating MRI and Neuropathology in TBI-related Dementia and VCIDNIHNational Institute of Neurological Disorders and Stroke2023 to 2025$4,539,313September 22, 2023August 31, 2028VAN DER KOUWE, ANDRE JAN WILLEMreporter.nih.gov
Capillaries as a Sensory Web that Controls Cerebral Blood Flow in Health and DiseaseNIHNational Heart, Lung, and Blood Institute2021 to 2025$4,511,697January 1, 2019December 31, 2026NELSON, MARK Treporter.nih.gov
African Ancestry and the Genomic Architecture of AD and Other Common Neurodegenerative Disease NeuropathologiesNIHNational Institute on Aging2021 to 2023$4,504,699September 15, 2016May 31, 2024BENNETT, DAVID ALANreporter.nih.gov
Portable Ankle Robotics to Reverse Foot Drop After Stroke.NIHNational Institute of Neurological Disorders and Stroke2021 to 2024$4,504,284May 1, 2021February 28, 2025HENNESSIE, BRADLEYreporter.nih.gov
Innovative Deep Phenotyping of African Americans at Risk for Alzheimers diseaseNIHNational Institute on Aging2023 to 2025$4,456,098June 1, 2023February 29, 2028LOEWENSTEIN, DAVIDreporter.nih.gov
Telerehabilitation In The Home After Stroke: A Randomized, Controlled, Assessor-Blind Clinical Trial (The TR-2 Trial)NIHNational Institute of Neurological Disorders and Stroke2025$4,453,239September 15, 2024August 31, 2029CRAMER, STEVEN C.reporter.nih.gov
A global epidemiology of cognitive impairment and dementia due to Alzheimer's disease and related disorders: the COSMIC CollaborationNIHNational Institute on Aging2023 to 2025$4,445,528September 15, 2017June 30, 2028SACHDEV, PERMINDER Sreporter.nih.gov
Telerehabilitation In The Home After Stroke: A Randomized, Controlled, Assessor-Blind Clinical Trial (The TR-2 Trial)NIHNational Institute of Neurological Disorders and Stroke2024$4,408,773September 15, 2024August 31, 2025CRAMER, STEVEN C.reporter.nih.gov
Cognitive Impairment and Dementia, Vascular Brain Injury, and Atrial Myopathy: Implications for Prevention of Alzheimer's Disease-Related DementiasNIHNational Institute of Neurological Disorders and Stroke2023$4,390,219September 20, 2023August 31, 2026CHEN, LIN YEEreporter.nih.gov
Precursors of Stroke Incidence and PrognosisNIHNational Institute of Neurological Disorders and Stroke2023 to 2025$4,368,194December 1, 1981August 31, 2028ROMERO, JOSE RAFAELreporter.nih.gov
VCID Center Without Walls for Understanding and Leveraging Small Vessel Cerebrovascular Disease Mechanisms in ADRDNIHNational Institute of Neurological Disorders and Stroke2024$4,361,625September 24, 2024August 31, 2027LEE, JIN-MOOreporter.nih.gov
Spreading Tau Pathology in Non-Amnestic Alzheimer's DiseaseNIHNational Institute on Aging2021 to 2025$4,306,312July 1, 2018June 30, 2028PHILLIPS, JEFFREY Sreporter.nih.gov
Highly Efficient MRI Pulse Sequences for High Resolution Physiological and Functional Brain ImagingNIHNational Institute of Mental Health2021 to 2023$4,281,145September 20, 2021August 31, 2025FEINBERG, DAVID ALANreporter.nih.gov
Experimental Cerebral Hemorrhage: Mechanisms and TherapiesNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$4,249,639May 1, 2020April 30, 2025XI, GUOHUAreporter.nih.gov
Neurovascular Interactions: Mechanisms, imaging, therapeutic potentialNIHNational Institute of Neurological Disorders and Stroke2021 to 2023$4,247,898September 1, 2016August 31, 2025AKASSOGLOU, KATERINAreporter.nih.gov
Leveraging novel mouse models to investigate toxic metal exposures on brain aging and Alzheimer's diseaseNIHNational Institute on Aging2024 to 2025$4,141,255September 30, 2024August 31, 2029GOLDSTEIN, LEE E.reporter.nih.gov
Cognitive Aging, Brain Morphology, and Arrhythmias in Hispanics/Latinos: Implications for Prevention and Management of Alzheimer's Disease-Related DementiasNIHNational Institute of Neurological Disorders and Stroke2022$4,131,388April 1, 2022March 31, 2025CHEN, LIN YEEreporter.nih.gov
Structural and diffusion changes of perivascular space in aging, cognitive decline and Alzheimer's diseaseNIHNational Institute on Aging2021 to 2025$4,101,683September 5, 2021June 30, 2027CHOUPAN, JEIRANreporter.nih.gov
AtRial Cardiopathy and Antithrombotic Drugs In prevention After cryptogenicstroke (ARCADIA)NIHNational Institute of Neurological Disorders and Stroke2021 to 2022$4,101,394May 1, 2017April 30, 2025MARSHALL, RANDOLPH Sreporter.nih.gov
Validation of small vessel vascular contributions to cognitive impairment and dementia (VCID) biomarkersNIHNational Institute of Neurological Disorders and Stroke2023 to 2025$4,093,112September 30, 2016July 31, 2027LU, HANZHANGreporter.nih.gov
Preclinical evaluation of tacrolimus in a canine model of Alzheimer's diseaseNIHNational Institute on Aging2022$4,083,505September 15, 2017May 31, 2025HEAD, ELIZABETHreporter.nih.gov
Vascular Pathology in Early and Asymptomatic Cerebral Amyloid AngiopathyNIHNational Institute on Aging2021 to 2025$3,993,325September 30, 2014March 31, 2027VISWANATHAN, ANANDreporter.nih.gov
Building an unbiased pooled cohort for the study of lifecourse social and vascular determinants of Alzheimer's Disease and Related DisordersNIHNational Institute on Aging2021 to 2025$3,985,562June 15, 2021March 31, 2027ZEKI AL HAZZOURI, ADINAreporter.nih.gov
ZZ-3K3A-301: A multicenter, randomized, placebo-controlled, double-blinded, Phase 3 study to evaluate the efficacy and safety of 3K3A-APC (RHAPSODY-2)NIHNational Institute of Neurological Disorders and Stroke2022$3,980,070June 1, 2022May 31, 2024LYDEN, PATRICK Dreporter.nih.gov
Preeclampsia and the Brain: Small vessel disease and cognitive function in early midlifeNIHNational Institute on Aging2022 to 2025$3,960,160February 1, 2022November 30, 2026CATOV, JANET Mreporter.nih.gov
Burden and change in Alzheimers disease neuropathology in aging World Trade Center respondersNIHNational Institute on Aging2021 to 2025$3,952,934March 15, 2021February 28, 2027CLOUSTON, SEANreporter.nih.gov
Synergistic white matter injury from diesel exhaust particulate and chronic cerebral hypoperfusion exposures: Interaction between the Nogo/NgR1 receptor pathway and extravascular fibrinogen toxicityNIHNational Institute of Neurological Disorders and Stroke2022 to 2025$3,929,367September 20, 2022August 31, 2027MACK, WILLIAM Jreporter.nih.gov
Depression treatment and Aβ dynamics: A study of Alzheimer’s disease riskNIHNational Institute on Aging2021 to 2025$3,865,122August 15, 2021July 31, 2027POMARA, NUNZIOreporter.nih.gov
Minimally Invasive Cerebral Blood Flow and Oxygenation Monitoring for Intracranial HypertensionNIHNational Institute of Neurological Disorders and Stroke2024 to 2025$3,861,972September 20, 2022November 30, 2026FLOYD, THOMAS FREDERICKreporter.nih.gov
Defining the Role of Post-TBI Sleep Disruption in the Development of CTE and Alzheimer's Disease-Related NeuropathologyNIHNational Institute of Neurological Disorders and Stroke2022$3,859,922September 20, 2022August 31, 2025PESKIND, ELAINE R.reporter.nih.gov
Validation of Imaging and Blood-based Small Vessel VCID Biomarkers in Multiethnic PopulationNIHNational Institute of Neurological Disorders and Stroke2023 to 2025$3,859,697September 30, 2021July 31, 2027WANG, DANNY JJreporter.nih.gov
PRE3BAD: Preclinical Research on Emerging Environmental Exposures, Brain Aging, and DementiaNIHNational Institute on Aging2024 to 2025$3,859,319September 30, 2024August 31, 2029CAMPEN, MATTHEW Jreporter.nih.gov
Perivascular fibroblasts, vascular fibrosis, and their contributions to cerebral amyloid angiopathyNIHNational Institute of Neurological Disorders and Stroke2022 to 2025$3,851,096September 19, 2022July 31, 2027LIPPMANN, ETHANreporter.nih.gov
Menopausal Vasomotor Symptoms and Brain Aging in WomenNIHNational Institute on Aging2021 to 2025$3,849,407August 15, 2016June 30, 2027THURSTON, REBECCA Creporter.nih.gov
Resilience to Cognitive Decline and Resistance to Alzheimer's Disease and Related Neurodegenerative Diseases in Individuals from Colombia with Autosomal Dominant DementiasNIHNational Institute of Neurological Disorders and Stroke2023$3,821,618August 15, 2023July 31, 2026QUIROZ, YAKEEL T.reporter.nih.gov
Long-Term Observational Extension of Participants in the CREST-2 Randomized Clinical TrialNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$3,784,947September 1, 2021August 31, 2026MESCHIA, JAMES Freporter.nih.gov
Alzheimer's Disease Pathology in a Primate ModelNIHNational Institute on Aging2021 to 2025$3,764,077February 15, 2021January 31, 2027HOPKINS, WILLIAM Dreporter.nih.gov
Effect of diabetes and AD pathology on brain imaging and cognition in Latino adultsNIHNational Institute on Aging2022$3,755,733September 30, 2022August 31, 2025YASSINE, HUSSEIN Nreporter.nih.gov
Digital Biomarkers for Vascular Cognitive Decline in Patients with Minor StrokeNIHNational Institute on Aging2022 to 2025$3,752,944September 10, 2022August 31, 2027MARSH, ELISABETH BREESEreporter.nih.gov
Cannabis and Pathogenic Mechanisms influencing Blood Brain Barrier Function in HIVNIHNational Institute on Drug Abuse2023 to 2025$3,726,178August 15, 2023June 30, 2028IUDICELLO, JENNIFER Ereporter.nih.gov
Neurocognition and Greater Maintenance of Sinus Rhythm in AF (NOGGIN AF)NIHNational Institute on Aging2021 to 2025$3,724,610September 1, 2021May 31, 2027MATHEW, JOSEPH Preporter.nih.gov
Digital Accessible Remote Olfactory Mediated Health Assessments forPreclinical ADNIHNational Institute on Aging2021 to 2025$3,718,193September 30, 2018June 30, 2027REINEKE, SEANreporter.nih.gov
TRP channels as fundamental sensors of the cerebral microcirculationNIHNational Heart, Lung, and Blood Institute2021 to 2024$3,709,945February 1, 2021July 31, 2024EARLEY, SCOTTreporter.nih.gov
Understanding the long term impact of COVID-19 on the brain through advanced MR imaging and spectroscopyNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$3,689,933July 15, 2021June 30, 2026OZ, GULINreporter.nih.gov
Reducing African Americans' Alzheimer's Disease Risk Through Exercise-MCI Cohort (RAATE-MCI)NIHNational Institute on Aging2021 to 2025$3,689,143July 1, 2020March 31, 2027NEWTON, ROBERT LEEreporter.nih.gov
Using human brain connectivity to identify the causal neuroanatomical substrate of depression symptomsNIHNational Institute of Mental Health2021 to 2025$3,675,908September 19, 2017June 30, 2027FOX, MICHAEL Dreporter.nih.gov
Understanding the role of senescence on post-operative neuroinflammationNIHNational Institute on Aging2022 to 2025$3,674,270September 15, 2022August 31, 2027VARGHESE, SHYNIreporter.nih.gov
Magnetic Resonance Imaging Guided Robotic Catheter System for Left Atrial Appendage Occlusion ProceduresNIHNational Heart, Lung, and Blood Institute2022 to 2025$3,666,425July 15, 2022June 30, 2027CAVUSOGLU, M. CENKreporter.nih.gov
Minocycline as a potential therapy for neuroinflammation and cognitive deficit in sickle cell diseaseNIHNational Heart, Lung, and Blood Institute2021 to 2025$3,659,814December 15, 2020November 30, 2026HYACINTH, HYACINTH IDUreporter.nih.gov
Lymphatics-Glymphatics in CNS Fluid HomeostasisNIHNational Center for Complementary & Integrative Health2021 to 2025$3,644,017April 1, 2021March 31, 2026BENVENISTE, HELENE Dreporter.nih.gov
Molecular and Physiological Mechanisms of Hypertensive Cerebral MicroangiopathyNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$3,627,088July 1, 2020April 30, 2026GUROL, MAHMUT EDIPreporter.nih.gov
Immunovascular interactions in postoperative delirium superimposed on dementia (DSD).NIHNational Institute on Aging2022 to 2025$3,624,866September 15, 2022August 31, 2027TERRANDO, NICCOLOreporter.nih.gov
The Rhythm Evaluation for Anticoagulation with Continuous Monitoring of Atrial Fibrillation Trial (REACT-AF)NIHNational Heart, Lung, and Blood Institute2022$3,610,112August 25, 2022July 31, 2023PASSMAN, ROD Sreporter.nih.gov
Towards personalized medicine: pathophysiologic contributions to post-stroke sleep apneaNIHNational Heart, Lung, and Blood Institute2023 to 2025$3,584,181April 10, 2023February 28, 2027BROWN, DEVIN Lreporter.nih.gov
Targeted Cerebral Spinal Fluid (CSF) Drug Delivery - Enclear Precision SystemNIHNational Institute of Neurological Disorders and Stroke2024 to 2025$3,564,917January 1, 2024December 31, 2026GLICKSMAN, MARCIE Areporter.nih.gov
CNS Exosomes-Mediated Adaptive Immunity in Alzheimer's Disease (AD)NIHNational Institute on Aging2022 to 2025$3,544,893September 1, 2022May 31, 2027YANG, YONGJIEreporter.nih.gov
A Novel Xenon Delivery Platform for Cerebroprotection During StrokeNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$3,536,579May 1, 2017August 31, 2027BOOHER, KEITHreporter.nih.gov
Advanced MRI studies of cerebrovascular and lymphatic abnormalities in LRRK2 mouse models of Parkinson's diseaseNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$3,536,285April 1, 2021March 31, 2027SMITH, WANLI Wreporter.nih.gov
Assessing the Role of Sex-Specific Genetic Drivers of Cerebrovascular Disease in the Alzheimer's Disease BrainNIHNational Institute on Aging2025$3,531,593September 1, 2025August 31, 2029DUMITRESCU, LOGAN Creporter.nih.gov
SARS-CoV-2 and Precursors of Alzheimer's Disease and Related Dementias: An Ultrahigh Field (7T) MRI Study in a Diverse Multinational CohortNIHNational Institute on Aging2021$3,529,440September 1, 2021August 31, 2025SESHADRI, SUDHAreporter.nih.gov
Locomotor function following transcutaneous electrical spinal cord stimulation in individuals with hemiplegic strokeNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2021 to 2025$3,493,081August 12, 2021July 31, 2027JAYARAMAN, ARUNreporter.nih.gov
SPRINT MIND 2020NIHNational Institute on Aging2021 to 2023$3,485,934June 15, 2017May 31, 2025REBOUSSIN, DAVID Mreporter.nih.gov
Longitudinal validation of cerebral small vessel disease biomarkers in diverse community-based older adults without dementiaNIHNational Institute of Neurological Disorders and Stroke2023 to 2025$3,480,622September 29, 2021July 31, 2027ARFANAKIS, KONSTANTINOSreporter.nih.gov
Construction of an Integrated Immune - Vascular Brain - Chip as a Platform for the Study, Drug Screening, and Treatments of Alzheimer's DiseaseNIHNational Institute of Neurological Disorders and Stroke2021 to 2023$3,475,569September 20, 2019May 31, 2024TSAI, LI-HUEIreporter.nih.gov
Cardiac Imaging of Neuro-Embolic Mechanisms in Atriopathies causing Stroke (CINEMAS)NIHNational Heart, Lung, and Blood Institute2024 to 2025$3,473,396May 1, 2024April 30, 2029GOLDBERGER, JEFFREY Jreporter.nih.gov
Resilient versus fragile aspects of blood flow in the mammalian brainNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$3,460,507December 1, 2016November 30, 2025KLEINFELD, DAVIDreporter.nih.gov
Role of Fibrinogen in Alzheimer's DiseaseNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$3,431,479April 1, 2018July 31, 2028STRICKLAND, SIDNEYreporter.nih.gov
SUPPORT-AF IVNIHNational Heart, Lung, and Blood Institute2021 to 2025$3,411,751August 1, 2021June 30, 2027KAPOOR, ALOKreporter.nih.gov
Wireless Nerve Stimulation Device To Enhance Recovery After StrokeNIHNational Institute of Neurological Disorders and Stroke2021 to 2023$3,408,782February 15, 2019March 31, 2026HAYS, SETH ALANSONreporter.nih.gov
The Role of PAI-1 in Cerebral Microvascular Dysfunction and the Development of Alzheimer’s Disease NeuropathologyNIHNational Institute on Aging2021 to 2025$3,397,256September 1, 2021June 30, 2027LAWRENCE, DANIEL Areporter.nih.gov
Blood-based AD biomarkers profile in CAPCOG-TBI studyNIHNational Institute of Neurological Disorders and Stroke2023 to 2025$3,393,269September 1, 2023May 31, 2028DING, KANreporter.nih.gov
Metabolic and neural activity normalization by cerebral blood flow increase in AD/ADRD modelsNIHNational Institute on Aging2023 to 2025$3,391,148April 15, 2023January 31, 2028SCHAFFER, CHRIS Breporter.nih.gov
FOcal Cerebral Arteriopathy Steroids (FOCAS) TrialNIHNational Institute of Neurological Disorders and Stroke2024 to 2025$3,369,954February 1, 2023January 31, 2030FULLERTON, HEATHER Jreporter.nih.gov
Sex Differences in Inflammation Across the LifespanNIHNational Institute of Neurological Disorders and Stroke2023 to 2025$3,353,112May 1, 2023April 30, 2031MCCULLOUGH, LOUISE D.reporter.nih.gov
BRain Aging and Cognition in Epilepsy (BRACE): A longitudinal investigation of vascular, genetic, and biomarker risk profiles in elderly patients with epilepsyNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$3,346,371September 1, 2021February 28, 2027MCDONALD, CARRIE Rreporter.nih.gov
High-Intensity Interval Training to Recover Walking Post-Stroke: HIT-Stroke Trial 2NIHEunice Kennedy Shriver National Institute of Child Health & Human Development2021 to 2025$3,332,016April 3, 2018June 30, 2028BOYNE, PIERCEreporter.nih.gov
Multiethnic Validation of VCID Biomarkers in South TexasNIHNational Institute of Neurological Disorders and Stroke2023 to 2025$3,325,938September 30, 2021July 31, 2027SATIZABAL, CLAUDIA Lreporter.nih.gov
Locus Coeruleus Imaging Markers in Preclinical Alzheimers disease, Cerebrovascular Disease and Cognitive DeclineNIHNational Institute on Aging2024 to 2025$3,322,482April 1, 2023March 31, 2029NATION, DANIEL Areporter.nih.gov
Innate Immunity Stimulation Effects on Biomarkers, Cognition, and the Vascular Amyloid Proteome in a Squirrel Monkey Model of Sporadic CAANIHNational Institute of Neurological Disorders and Stroke2022 to 2025$3,321,272July 15, 2022June 30, 2027SCHOLTZOVA, HENRIETAreporter.nih.gov
Brain Effects of Lifetime Racial/Ethnic Discrimination on the LC-NE Function and the Risk for Alzheimer's DiseaseNIHNational Institute on Aging2021 to 2024$3,312,473September 5, 2021June 30, 2026DING, YU-SHINreporter.nih.gov
ARIA Pathophysiology Characterized by in vivo Neuroimaging, Plasma Biomarkers and Post-Mortem ProteomicsNIHNational Institute of Neurological Disorders and Stroke2025$3,310,951June 4, 2025May 31, 2027WISNIEWSKI, THOMAS Mreporter.nih.gov
Low Neurophysiologic Resistance to Anesthetics as a Marker of Preclinical/Prodromal Alzheimer's Disease and Neurovascular Pathology, Delirium risk and InattentionNIHNational Institute on Aging2022 to 2025$3,308,332August 1, 2022April 30, 2027DEVINNEY, MICHAEL JOSEPHreporter.nih.gov
Strategy for Improving Stroke Treatment Response (SISTER) TrialNIHNational Institute of Neurological Disorders and Stroke2024$3,308,306July 1, 2023June 30, 2028KHATRI, POOJAreporter.nih.gov
Comparative Safety of Seizure Prophylaxis within the Medicare ProgramNIHNational Institute on Aging2021 to 2025$3,302,661September 30, 2021May 31, 2027MOURA, LIDIA MARIA VERAS ROCHA DEreporter.nih.gov
Assessment of Mast Cell Degranulation in Infarcted Myocardium Using Quantitative Multiparametric MRINIHNational Heart, Lung, and Blood Institute2022 to 2025$3,298,936July 1, 2022June 30, 2027LI, DEBIAOreporter.nih.gov
Access to and effectiveness of community-based rehabilitation after strokeNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2021 to 2025$3,292,828July 8, 2021June 30, 2027FREBURGER, JANET KUESreporter.nih.gov
Role of GPR39 in Aging-Related Vascular Cognitive Impairment (VCI)NIHNational Institute on Aging2022 to 2025$3,287,439September 15, 2022August 31, 2027ALKAYED, NABIL Jreporter.nih.gov
The role of blood and brain 5-hydroxymethylcytosine in linking vascular risk factors to ADRD in older White and Black personsNIHNational Institute on Aging2021$3,275,232August 15, 2021July 31, 2024ARVANITAKIS, ZOEreporter.nih.gov
Treating Brain Swelling in Pediatric Cerebral MalariaNIHNational Institute of Allergy and Infectious Diseases2021 to 2023$3,271,417December 12, 2016November 30, 2023TAYLOR, TERRIE ELLENreporter.nih.gov
Low-Dose Magneto-Thrombolysis to Expand Stroke CareNIHNational Institute of Neurological Disorders and Stroke2023 to 2024$3,263,292July 1, 2023June 30, 2026CREIGHTON, FRANCIS MILTONreporter.nih.gov
The Video-based Intervention to Reduce Hypertension Treatment and OUtcome Differences in Adults Living with Stroke or Transient Ischemic Attack (VIRTUAL)NIHNational Institute on Minority Health and Health Disparities2021 to 2025$3,254,165September 18, 2021May 31, 2027SHARRIEF, ANJAIL Zreporter.nih.gov
PET Imaging of ThrombusNIHNational Heart, Lung, and Blood Institute2022 to 2025$3,247,850August 1, 2011January 31, 2027CARAVAN, PETER Dreporter.nih.gov
Microglia-Amyloid interactions in delirium superimposed on dementiaNIHNational Institute on Aging2021 to 2025$3,246,663September 15, 2017December 31, 2027TERRANDO, NICCOLOreporter.nih.gov
Role of endothelium in pathogenesis of cerebral amyloid angiopathyNIHNational Institute on Aging2021 to 2025$3,245,352September 1, 2021June 30, 2026KATUSIC, ZVONIMIR Sreporter.nih.gov
ApoE4, Neurovascular Injury and Cognitive ImpairmentNIHNational Institute of Neurological Disorders and Stroke2022 to 2025$3,244,519April 1, 2022March 31, 2027IADECOLA, COSTANTINOreporter.nih.gov
Anatomy of the circle of Willis, cerebral blood flow, and Alzheimer's disease biomarkers in hypertensionNIHNational Heart, Lung, and Blood Institute2022 to 2025$3,226,267March 6, 2012March 31, 2027GLODZIK, LIDIAreporter.nih.gov
Cerebral hemodynamic impairment in symptomatic and asymptomatic Alzheimer's DiseaseNIHNational Institute on Aging2022 to 2025$3,221,061February 1, 2022January 31, 2027QIU, DEQIANGreporter.nih.gov
Investigating the Thalamic Regulation of Neuro-Glio-Vascular Restoration Underlying Acute Coma Recovery with Multi-Modal fMRI in a Brainstem Coma Rodent ModelNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$3,220,162August 1, 2021May 31, 2027YU, XINreporter.nih.gov
Understanding the Mechanisms of Change and Optimal Parameters in Conversation Treatment for AphasiaNIHNational Institute on Deafness and Other Communication Disorders2021 to 2025$3,217,654April 1, 2021March 31, 2027HOOVER, ELIZABETH Lreporter.nih.gov
Vascular contribution to white matter lesions and motor dysfunction in AD and ADRDNIHNational Institute on Aging2022 to 2025$3,210,645September 15, 2022August 31, 2027AHN, HYUNG JINreporter.nih.gov
RCT Targeting Cognition in Early Alzheimer's Disease by Improving Sleep with Trazodone (Rest)NIHNational Institute on Aging2021 to 2024$3,203,115September 15, 2021August 31, 2026GREENBERG, BARRY DAVIDreporter.nih.gov
Characterization of relationship between tau pathology and neurodegeneration in Alzheimer's disease using multimodal imagingNIHNational Institute on Aging2022 to 2025$3,200,041April 15, 2022January 31, 2027DAS, SANDHITSUreporter.nih.gov
Extreme weather, air pollution, and stroke among an aging female populationNIHNational Institute of Environmental Health Sciences2021 to 2025$3,191,631September 2, 2021June 30, 2027WANG, SOPHIA Sreporter.nih.gov
Effects of vascular risk factors on risk for dementia and stroke after late-onset epilepsy (EpilepsyCOG)NIHNational Institute on Aging2022 to 2025$3,188,533July 1, 2022March 31, 2027CHOI, HYUNMIreporter.nih.gov
Cocaine use, viral suppression and precursors of stroke in HIV infectionNIHNational Institute on Drug Abuse2021 to 2024$3,185,105June 1, 2020April 30, 2026RILEY, ELISE D.reporter.nih.gov
Novel Imaging and Biofluid Biomarkers of Small Vessel Cerebrovascular DiseaseNIHNational Institute of Neurological Disorders and Stroke2023 to 2025$3,180,774September 29, 2021July 31, 2027KRAMER, JOEL Hreporter.nih.gov
Cerebrovascular Remodeling and Neurodegenerative Changes in Alzheimer's DiseaseNIHNational Institute on Aging2022 to 2025$3,178,600February 1, 2022January 31, 2027ZHANG, YANHANG KATHERINEreporter.nih.gov
Deep Phenotypic Characterization of Prodromal Dementia with Lewy BodiesNIHNational Institute on Aging2022$3,171,435September 30, 2022August 31, 2025GALVIN, JAMES Ereporter.nih.gov
Contributions of modifiable physical attributes to cognitive and brain agingNIHNational Institute on Aging2021 to 2025$3,167,967May 15, 2021April 30, 2027HAYES, SCOTT Mreporter.nih.gov
Peroxynitrite is a Molecular Determinant of Impaired Microvascular Energetics in Alzheimer's DiseaseNIHNational Institute on Aging2021 to 2025$3,155,638September 1, 2021June 30, 2027KATAKAM, PRASAD Vreporter.nih.gov
Carotid Revascularization and Medical Management for Asymptomatic CarotidStenosis Trial - Hemodynamics (CREST-H)NIHNational Institute of Neurological Disorders and Stroke2021 to 2025$3,153,445May 15, 2017July 31, 2027MARSHALL, RANDOLPH Sreporter.nih.gov
Optimizing Targeted Interventions for AphasiaNIHNational Institute on Deafness and Other Communication Disorders2021 to 2025$3,145,007May 1, 2021April 30, 2027RICHARDSON, JESSICA Dreporter.nih.gov
POINTER-zzz: Sleep Ancillary to U.S. Study to Protect Brain Health through Lifestyle Intervention to Reduce Risk of Alzheimer's DiseaseNIHNational Institute on Aging2021 to 2023$3,144,541August 15, 2019May 31, 2025BAKER, LAURA D.reporter.nih.gov
Role of vascular KATP channels in Alzheimer’s neurodegeneration and dementiaNIHNational Heart, Lung, and Blood Institute2021 to 2023$3,134,584January 1, 2018December 31, 2023NICHOLS, COLIN Greporter.nih.gov
Investigating Resistance and Resilience Mechanisms in Alzheimer’s DiseaseNIHNational Institute on Aging2021 to 2025$3,131,976September 15, 2017February 29, 2028VEMURI, PRASHANTHIreporter.nih.gov
Brain pathophysiology in SARS-CoV-2 diseaseNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$3,121,854July 1, 2021April 30, 2027SANDBERG, KATHRYN Lreporter.nih.gov
Defective heme transport in the development of congenital hydrocephalusNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$3,120,419September 1, 2021June 30, 2026ARNOLD, THOMAS DARMODYreporter.nih.gov
Alzheimer's Abeta, Tau, Apolipoproteins and Blood-brain barrierNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$3,119,037September 1, 1995February 28, 2026YASSINE, HUSSEIN Nreporter.nih.gov
Longitudinal MRI Investigation of Traumatic Microvascular InjuryNIHNational Institute of Neurological Disorders and Stroke2022 to 2025$3,116,729February 15, 2022January 31, 2027WARE, JEFFREY Breporter.nih.gov
Impairment of Ischemia-induced Vascular Functions by PS1 FAD MutantsNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$3,116,100January 15, 2021December 31, 2025GEORGAKOPOULOS, ANASTASIOSreporter.nih.gov
Probing Role of Tetrahydrobiopterin in Cerebral Palsy by Using Transgenic RabbitsNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$3,115,975December 15, 2020November 30, 2026TAN, SIDHARTHAreporter.nih.gov
Alzheimer's Disease Hallmark Pathology and Associated Inflammation in the RetinaNIHNational Institute on Aging2021 to 2025$3,113,565April 1, 2018June 30, 2028KORONYO-HAMAOUI, MAYAreporter.nih.gov
Blood Pressure and ADRD in African Americans: the Jackson Heart StudyNIHNational Institute on Aging2021 to 2022$3,111,832September 15, 2019August 31, 2022PALTA, PRIYAreporter.nih.gov
Implicit Structural Priming as a Treatment Component in AphasiaNIHNational Institute on Deafness and Other Communication Disorders2021 to 2025$3,109,320August 1, 2021May 31, 2027LEE, JIYEONreporter.nih.gov
Recovery of StrokE - Longitudinal Assessment With Neuroimaging (ROSE LAWN)NIHNational Institute of Neurological Disorders and Stroke2021 to 2024$3,104,674December 15, 2020November 30, 2025WOO, DANIELreporter.nih.gov
Integrating TPM and PAM to examine the metabolic underpinning of neurovascular repair after strokeNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$3,104,362September 1, 2021June 30, 2026HU, SONGreporter.nih.gov
Advanced MR Imaging of Olfactory Impairment in Prodromal Alzheimer's DiseaseNIHNational Institute on Aging2021 to 2024$3,102,717May 1, 2020February 28, 2026HUA, JUNreporter.nih.gov
Improving Cerebral Aneurysm Risk Assessment through Understanding Wall Vulnerability and Failure ModesNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$3,091,944July 1, 2016April 30, 2027ROBERTSON, ANNE MARIEreporter.nih.gov
The Impact of Cerebral Metabolic Stress on the Development of the Structural and Functional Connectome in Pediatric Sickle Cell AnemiaNIHNational Heart, Lung, and Blood Institute2021 to 2025$3,089,102April 5, 2021March 31, 2027FIELDS, MELANIE ERINreporter.nih.gov
Quantifying and Treating Myofascial Dysfunction in Post Stroke Shoulder PainNIHNational Center for Complementary & Integrative Health2024$3,086,679September 21, 2022August 31, 2027RAGHAVAN, PREETIreporter.nih.gov
Residential Radon Exposure and Stroke Risk: the REGARDS StudyNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$3,084,826May 1, 2021March 31, 2027KAHE, KAreporter.nih.gov
Immune Cells in Alzheimer’s Disease and Related Dementias in the Jackson Heart StudyNIHNational Institute on Aging2022 to 2025$3,079,808March 1, 2022November 30, 2026RAFFIELD, LAURA Mreporter.nih.gov
Cerebrovascular contributions to Alzheimer's disease in adults with Down SyndromeNIHNational Institute on Aging2022$3,079,273September 30, 2022August 31, 2025BRICKMAN, ADAM Mreporter.nih.gov
Covert Cerebrovascular Disease Detected by Artificial Intelligence (C2D2AI): A Platform for Pragmatic Evidence Generation for Stroke and Dementia PreventionNIHNational Institute of Neurological Disorders and Stroke2023 to 2025$3,076,281February 1, 2023January 31, 2026KENT, DAVID Mreporter.nih.gov
Bio-digital Rapid Alert to Identify NeuromorbidityNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$3,073,530August 1, 2021June 30, 2027CLARK, ROBERT S Breporter.nih.gov
Novel Volumetric Optical Microscopy to Unravel Cerebral Microvascular Architecture and the Role in Functional Neuroimaging in Human Alzheimer's DiseaseNIHNational Institute of Neurological Disorders and Stroke2022 to 2025$3,069,316August 1, 2022July 31, 2027WANG, HUIreporter.nih.gov
The glymphatic system at the crossroad of integrative health approaches inchronic painNIHNational Center for Complementary & Integrative Health2021 to 2025$3,067,927August 1, 2021May 31, 2026NEDERGAARD, MAIKENreporter.nih.gov
Efflux Route Responses of Cerebral Waste Clearance During Progression of Alzheimer’s DiseaseNIHNational Institute on Aging2025$3,062,355September 15, 2025August 31, 2029JIANG, QUANreporter.nih.gov
Impaired Vasoreactivity, Sleep Degradation, and Impaired Clearance in the APOE4 BrainNIHNational Institute on Aging2022 to 2025$3,058,861July 15, 2022June 30, 2025PROCTOR, ELIZABETH Areporter.nih.gov
Single-cell multi-region transcriptional and epigenomic dissection of VCID.NIHNational Institute of Neurological Disorders and Stroke2022$3,058,535September 15, 2022August 31, 2025KELLIS, MANOLISreporter.nih.gov
The role of tissue nonspecific alkaline phosphatase in brain endothelial cell homeostasisNIHNational Institute on Aging2021 to 2025$3,056,287June 1, 2021March 31, 2026BROWN, CANDICEreporter.nih.gov
The Amylin Dyshomeostasis Hypothesis of Vascular Contributions to Cognitive Impairment and Dementia (VCID)NIHNational Institute of Neurological Disorders and Stroke2021 to 2024$3,056,084April 1, 2020March 31, 2026DESPA, FLORINreporter.nih.gov
Quantitative model-based ESUS reclassification using cardiac and cerebral vessel wall MRINIHNational Institute of Neurological Disorders and Stroke2022 to 2025$3,048,621September 21, 2022August 31, 2027YUAN, CHUNreporter.nih.gov
Intracranial arterial compliance, cerebral blood flow, and dementia risk in older adults with type 2 diabetesNIHNational Institute on Aging2021 to 2024$3,038,302May 1, 2020February 28, 2026BANGEN, KATHERINEreporter.nih.gov
Development of an ophthalmic diagnostic probe for cerebral amyloid angiopathy in patientsNIHNational Institute on Aging2021 to 2022$3,033,670June 1, 2021May 31, 2024SARRAF, STELLAreporter.nih.gov
Optogenetic Approaches to Study Post-Stroke Recovery MechanismsNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$3,033,534August 1, 2015November 30, 2026STEINBERG, GARY Kreporter.nih.gov
Aging Research Characterizing Health Equity via Social determinants (ARCHES)NIHNational Institute on Aging2021 to 2024$3,033,223September 1, 2021May 31, 2026BABULAL, GANESH Mreporter.nih.gov
Noninvasive sensory stimulation to promote glymphatic-lymphatic clearance for the treatment of Alzheimer’s DiseaseNIHNational Center for Complementary & Integrative Health2021 to 2025$3,032,391May 15, 2021April 30, 2026TSAI, LI-HUEIreporter.nih.gov
Targeting Pyruvate Kinase M2: A novel strategy to combat thrombo-inflammationNIHNational Heart, Lung, and Blood Institute2021 to 2024$3,020,183April 1, 2018March 31, 2025CHAUHAN, ANIL KUMARreporter.nih.gov
Acceleration of Circulatory and Neurological Aging due to Wildfire ExposuresNIHNational Institute on Aging2022 to 2025$3,018,937January 1, 2022December 31, 2026CAMPEN, MATTHEW Jreporter.nih.gov
Atherosclerosis in cocaine addiction: imaging risk with PET/MRNIHNational Institute on Drug Abuse2022 to 2025$3,015,410June 1, 2022March 31, 2027ALIA-KLEIN, NELLYreporter.nih.gov
Harnessing human brain and liver microphysiological systems for testing therapeutics for metastatic melanomaNIHNational Center for Advancing Translational Sciences2021 to 2022$3,003,024August 1, 2018July 31, 2024WIKSWO, JOHN PETERreporter.nih.gov
The role of cannabinoids in the regulation of the blood brain barrier in the context of NeuroHIV and anti-retroviral therapyNIHNational Institute on Drug Abuse2021 to 2025$2,992,059April 1, 2021December 31, 2025PERSIDSKY, YURIreporter.nih.gov
Gas-free cerebrovascular reactivity (CVR) MRI in vascular cognitive impairmentNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$2,984,490August 16, 2021July 31, 2027LIU, PEIYINGreporter.nih.gov
The NOTCH Signaling Pathway in Large Vessel VasculitisNIHNational Heart, Lung, and Blood Institute2021 to 2025$2,984,128January 6, 2014June 30, 2027WEYAND, CORNELIA M.reporter.nih.gov
Novel Targets and Therapeutic Interventions against Cerebral Ischemia-Reperfusion InjuryNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$2,982,207June 1, 2021May 31, 2027LI, GUOHONGreporter.nih.gov
Super Resolution Ultrasound Imaging of Vasa Vasorum to Characterize the Progression of Atherosclerotic Plaques and Predict Rupture VulnerabilityNIHNational Heart, Lung, and Blood Institute2022 to 2025$2,981,035February 1, 2022January 31, 2027KIM, KANGreporter.nih.gov
Safety and Tolerability Studies for an Anti-Fibrin P2 Monoclonal Antibody for the Treatment of Alzheimer's DiseaseNIHNational Institute on Aging2021 to 2023$2,970,786September 30, 2021August 31, 2024KANTOR, AARON Breporter.nih.gov
Testing efficacy of an intervention to promote Resilience in Stroke survivor-carepartner Dyads (ReStoreD)NIHEunice Kennedy Shriver National Institute of Child Health & Human Development2021 to 2025$2,967,735September 3, 2021August 31, 2027TERRILL, ALEXANDRAreporter.nih.gov
Social networks and risk of delayed arrival to the hospital during strokeNIHNational Institute on Minority Health and Health Disparities2022 to 2025$2,967,153April 20, 2022January 31, 2027DHAND, AMARreporter.nih.gov
Comprehensive Outcome Assessment after Severe Acute Brain Injury: Advanced Symptoms and End-of-Life Care NeedsNIHNational Institute of Nursing Research2021 to 2025$2,965,004May 12, 2021March 31, 2027CREUTZFELDT, CLAIRE JOHANNAreporter.nih.gov
Air Pollution and Alzheimer's Dementia: Neuropathologic and Olfactory Mechanisms in Multi-Ethnic Longitudinal CohortsNIHNational Institute on Aging2021 to 2024$2,963,574April 15, 2020January 31, 2026WEUVE, JENNIFERreporter.nih.gov
Effectiveness and Safety of Transcatheter Left Atrial Appendage Occlusion vs. Anticoagulation in Older Adults with Atrial Fibrillation and Alzheimer's Disease and Related dementiasNIHNational Institute on Aging2022 to 2025$2,962,676August 1, 2022April 30, 2027LIN, JOSHUA Kreporter.nih.gov
Neural Correlates of Recovery from Aphasia After StrokeNIHNational Institute on Deafness and Other Communication Disorders2021 to 2025$2,962,101June 1, 2014June 30, 2030DE RIESTHAL, MICHAEL Rreporter.nih.gov
Dementia prevalence, APOE, and blood-based biomarkers of AD in Native American communitiesNIHNational Institute on Aging2022 to 2025$2,961,521August 15, 2022April 30, 2027MANTYH, WILLIAM Greporter.nih.gov
Air pollution and early signs of dementiaNIHNational Institute on Aging2022 to 2025$2,959,713September 30, 2022August 31, 2027HUELS, ANKEreporter.nih.gov
Brain signature of SARS-CoV-2 Infection and its impact on long-term cognitive functioning in older adultsNIHNational Institute on Aging2022 to 2025$2,954,828July 1, 2022June 30, 2027SCHIFITTO, GIOVANNIreporter.nih.gov
Development and Evaluation of Portable Compendium of Psychophysical and Physiological Tests for Alzheimer's Disease and Related Dementias (ADRD)NIHNational Institute on Aging2023 to 2025$2,947,375August 1, 2023April 30, 2026NWAOKOBIA, CHARLES CHIEDUreporter.nih.gov
Global Brain Health Predictors of Post-Stroke Sensorimotor Recovery using AI-Enhanced Clinical MRIsNIHNational Institute of Neurological Disorders and Stroke2025$2,942,690April 1, 2020June 30, 2029LIEW, SOOK-LEIreporter.nih.gov
Stroke Connectome MRI Biomarkers for VCID Risk AssessmentNIHNational Institute of Neurological Disorders and Stroke2022 to 2025$2,928,784April 1, 2022March 31, 2027NAIR, VEENA Areporter.nih.gov
Deciphering molecular mechanisms that underlie brain endothelial cell dysfunction with APOE4NIHNational Institute on Aging2021 to 2025$2,926,569February 1, 2019February 28, 2029TAI, LEON MAINGreporter.nih.gov
StrokeWear: A Novel Wrist Wearable Sensor System to Promote Hemiparetic Upper Extremity Use in Home Daily Life.NIHEunice Kennedy Shriver National Institute of Child Health & Human Development2022 to 2024$2,924,294September 8, 2015August 31, 2025VAZIRI, ASHKANreporter.nih.gov
The impact of enculturation on the epigenetic relationship between chronic stress and hypertension in Yup'ik Alaska Native peopleNIHNational Institute on Minority Health and Health Disparities2021 to 2025$2,921,720February 2, 2021December 31, 2026BOYER, BERT BRANDONreporter.nih.gov
Role of RNAs in post-stroke brain damageNIHNational Institute of Neurological Disorders and Stroke2023 to 2025$2,913,162May 1, 2023April 30, 2031VEMUGANTI, RAGHUreporter.nih.gov
Blood brain barrier integrity and immune dynamics contributing to neuropsychiatric sequela in COVID long-haulersNIHNational Institute of Mental Health2023$2,906,437May 1, 2023April 30, 2026RUBIN, LEAH HELANEreporter.nih.gov
Blood-Brain Barrier Repair in Alzheimer’s Disease with EpilepsyNIHNational Institute on Aging2022 to 2025$2,905,702May 1, 2022April 30, 2027HARTZ, ANIKA M.S.reporter.nih.gov
Longitudinal multi-omic biomarkers for neurocognitive decline prior to dementia onsetNIHNational Institute on Aging2024 to 2025$2,904,500September 30, 2024June 30, 2029HARRIS, SARAH ELIZABETHreporter.nih.gov
MyoRegulator: A Non-Invasive Neuromodulation Device for Treatment of Spasticity in Stroke PatientsNIHNational Institute of Neurological Disorders and Stroke2021 to 2022$2,897,379February 15, 2018July 31, 2024YAGHOUBI, NADERreporter.nih.gov
Transporter Elucidation Center at the University of California, San FranciscoNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2023 to 2025$2,896,743September 19, 2023June 30, 2028GIACOMINI, KATHLEEN Mreporter.nih.gov
Dietary Sodium, Neurovascular Dysfunction and Cerebrovascular RiskNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$2,895,400December 1, 2015June 30, 2027IADECOLA, COSTANTINOreporter.nih.gov
Development of a Molecular Diagnostic to Identify Dangerous Intracranial AneurysmsNIHNational Institute of Neurological Disorders and Stroke2023 to 2025$2,888,564September 30, 2019August 31, 2027POPPENBERG, KERRYreporter.nih.gov
SIESTA (Sleep of Inpatients: Empower Staff to Act) for Acute Stroke Rehabilitation - Resubmission 01NIHEunice Kennedy Shriver National Institute of Child Health & Human Development2021 to 2024$2,877,850January 22, 2020December 31, 2025ARORA, VINEETreporter.nih.gov
Roles of Gray Matter Brain Aging and Small Vessel Disease in AD PathophysiologyNIHNational Institute on Aging2024 to 2025$2,872,909March 1, 2005February 28, 2027AIZENSTEIN, HOWARD Jreporter.nih.gov
Multiethnic machine learning brain signatures of ADRDNIHNational Institute on Aging2022 to 2025$2,860,890September 1, 2022June 30, 2027HABES, MOHAMADreporter.nih.gov
Elucidating Molecular Drivers of Aging and Alzheimer's Disease via Multimodal Imaging Mass SpectrometryNIHNational Institute on Aging2022 to 2025$2,856,050September 1, 2022June 30, 2027SPRAGGINS, JEFFREY Mreporter.nih.gov
Exerkines and the heterogeneity of peripheral and cerebral vascular adaptations to exercise training with aging in women and menNIHNational Institute on Aging2024 to 2025$2,854,677August 15, 2024July 31, 2030MOREAU, KERRIEreporter.nih.gov
Auracle: An AI-Enabled Telecare System to Support the Independence and Safety of Individuals with AD/ADRD and Other DementiasNIHNational Institute on Aging2021 to 2023$2,851,310September 1, 2021August 31, 2025FAUCI, MARK Areporter.nih.gov
Are there ethnic differences in brain amyloid and tau in the seventh decade of life?NIHNational Institute on Aging2021 to 2022$2,845,324August 1, 2017April 30, 2024LUCHSINGER, JOSE ALEJANDROreporter.nih.gov
The NIH SPAN Coordinating CenterNIHNational Institute of Neurological Disorders and Stroke2023 to 2025$2,843,122January 1, 2023December 31, 2026LYDEN, PATRICK Dreporter.nih.gov
Neonatal Hypoxic Ischemic Encephalopathy: Potential of Innovative NIRS to Optimize HypothermiaNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2022 to 2025$2,842,932June 1, 2014May 31, 2027GRANT, PATRICIA ELLENreporter.nih.gov
Portable, Low Field Brain Magnetic Resonance Imaging (MRI) for Acute StrokeNIHNational Institute of Biomedical Imaging and Bioengineering2022 to 2025$2,842,441April 1, 2022December 31, 2026SHETH, KEVIN NAVINreporter.nih.gov
Effects of Resonance-Frequency Breathing on Preclinical Alzheimer’s Disease Biomarkers and CognitionNIHNational Institute on Aging2023 to 2025$2,839,330January 15, 2023December 31, 2027MATHER, MARAreporter.nih.gov
Biomarkers of ischemic brain injury in adults with sickle cell diseaseNIHNational Heart, Lung, and Blood Institute2022 to 2025$2,834,684February 15, 2022January 31, 2027JORDAN, LORI CHAFFINreporter.nih.gov
Multiscale Model of Thrombosis in Artificial CirculationNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,819,437February 1, 2009April 30, 2026ANTAKI, JAMES F.reporter.nih.gov
Novel α2-Antiplasmin Inactivation for Lysis of Intravascular Thrombi (NAIL-IT) TrialNIHNational Heart, Lung, and Blood Institute2021 to 2022$2,817,681July 5, 2021March 31, 2025JEONG, SUN YONGreporter.nih.gov
Omega 3 Fatty Acids, Acute Neuroprotection Via MitochondriaNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$2,814,600April 1, 2015June 30, 2026CHANG, CHUCHUN LIZreporter.nih.gov
The relationship between ocus-coeruleus-norepinephrine network and neurovascular coupling in health and diseaseNIHNational Institute of Neurological Disorders and Stroke2025$2,813,759August 15, 2025July 31, 2029TRAN, CAM HA THAIreporter.nih.gov
Mechanisms of endothelial dysfunction in cerebral malaria and barrier restorative pathwaysNIHNational Institute of Allergy and Infectious Diseases2021 to 2024$2,808,572September 23, 2020August 31, 2025SMITH, JOSEPH Dreporter.nih.gov
Shear Stress and Endothelial Pathophysiology in Intracranial AtherosclerosisNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$2,803,513February 1, 2020October 31, 2025LIEBESKIND, DAVID SIGMUNDreporter.nih.gov
Risk Factors for Ischemic Stroke in WomenNIHNational Heart, Lung, and Blood Institute2022 to 2025$2,802,365September 11, 2008May 31, 2027REXRODE, KATHRYN Mreporter.nih.gov
A Receptor-Targeted Nanoparticle PET Tracer in Human Carotid AtherosclerosisNIHNational Heart, Lung, and Blood Institute2022 to 2025$2,801,867August 1, 2022May 31, 2027WOODARD, PAMELA Kreporter.nih.gov
Biomaterials Strategies to Promote Functional Recovery After Ischemic StrokeNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$2,801,281March 1, 2020June 30, 2030SEGURA, TATIANAreporter.nih.gov
An Epidemiologic Study of Disparities in Sleep and Cognition in Older Adults (DISCO)NIHNational Institute on Aging2021 to 2023$2,797,984July 1, 2019March 31, 2024KNUTSON, KRISTENreporter.nih.gov
Pathological mechanisms of white matter hyperintensitiesNIHNational Institute on Aging2021 to 2024$2,796,704September 1, 2021January 15, 2025RANE LEVENDOVSZKY, SWATIreporter.nih.gov
Modeling and Therapeutic Approaches for Genetic VasculopathiesNIHNational Institute of Neurological Disorders and Stroke2022 to 2025$2,784,876September 20, 2022July 31, 2027MUSOLINO, PATRICIA Lreporter.nih.gov
Investigating the Microvascular Mechanisms of O2 Supply-Demand Mismatch in Small Vessel Disease using Novel High-Resolution Optical ImagingNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$2,778,545May 1, 2020April 30, 2026SAKADZIC, SAVAreporter.nih.gov
Inter-alpha Inhibitors in Hypoxic-Ischemic Brain InjuryNIHNational Institute of Neurological Disorders and Stroke2023$2,776,920July 1, 2014August 31, 2026LIM, YOW-PINreporter.nih.gov
BBB Dysfunction in Post-Stroke DementiaNIHNational Institute of Neurological Disorders and Stroke2022 to 2025$2,776,180September 15, 2022August 31, 2027BUCKWALTER, MARION Sreporter.nih.gov
IND-enabling studies for a potent and efficient neuroprotective drugNIHNational Institute of Neurological Disorders and Stroke2024 to 2025$2,771,586September 24, 2021August 31, 2027GOFORTH, ROBYN Lreporter.nih.gov
Immune dynamics shaping blood brain barrier integrity in virally suppressed people with HIVNIHNational Institute of Mental Health2021 to 2024$2,763,350September 15, 2020June 30, 2025RUBIN, LEAH HELANEreporter.nih.gov
The Use of Deferiprone to Improve Subarachnoid Hemorrhage Cognitive Outcome: U-DISCONIHNational Institute on Aging2022 to 2025$2,761,884June 15, 2022April 30, 2027HASAN, DAVID Mreporter.nih.gov
Functional and neurophysiological effects of a progressive robot assisted gait intervention early post strokeNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2021 to 2024$2,760,575August 15, 2019November 30, 2025NOLAN, KAREN J.reporter.nih.gov
Identification, Quantification, and Functional Characterization of Transporters in Human Placenta, Developing Gut and Fetal BrainNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2023 to 2025$2,755,586August 11, 2023June 30, 2028WANG, JOANNEreporter.nih.gov
Neural activity-dependent modulation of cortical microvascular restorationNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$2,739,026March 15, 2021December 31, 2025XU, XIANGMINreporter.nih.gov
Vision recovery in cortical blindnessNIHNational Eye Institute2021 to 2025$2,738,966February 1, 2017January 31, 2027HUXLIN, KRYSTEL Rreporter.nih.gov
Cerebellar stimulation for Aphasia RehabilitationNIHNational Institute on Deafness and Other Communication Disorders2022 to 2025$2,738,083September 1, 2022August 31, 2027SEBASTIAN, RAJANIreporter.nih.gov
3D Models of the Blood-Brain Barrier for Studying Trauma-Induced Cerebral and Systemic InjuriesNIHNational Heart, Lung, and Blood Institute2022 to 2024$2,735,039September 3, 2020August 31, 2025ZHENG, YINGreporter.nih.gov
Role of Microthrombi and Inflammation in Delayed Deficits after SAHNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$2,731,086December 1, 2020November 30, 2026MCBRIDE, DEVIN WILLIAMreporter.nih.gov
Favorable cardiovascular health, connectome integrity, and ADRD clinical outcomes and pathologic underpinnings in a diverse cohort.NIHNational Institute on Aging2022 to 2025$2,728,963August 1, 2022July 31, 2028LAMAR, MELISSAreporter.nih.gov
Validation of Prenatal Rabbit Hypoxia Ischemia as a Model of Cerebral Palsy-induced PainNIHNational Institute of Neurological Disorders and Stroke2023$2,727,001September 19, 2023August 31, 2026QUINLAN, KATHARINA ANNreporter.nih.gov
Angiopoietin-2 Signaling Targeted Therapeutics for Arteriovenous MalformationsNIHNational Heart, Lung, and Blood Institute2022 to 2025$2,722,127April 1, 2022March 31, 2027MEADOWS, STRYDER MEDOAHreporter.nih.gov
Metabolic and Vascular Factors in tau pathogenesisNIHNational Institute on Aging2021 to 2024$2,720,466September 15, 2020May 31, 2025FRAUTSCHY, SALLY ANNreporter.nih.gov
Motor Recovery through Plasticity-Inducing Cortical StimulationNIHNational Institute of Neurological Disorders and Stroke2022 to 2024$2,719,092April 1, 2022March 31, 2029OJEMANN, JEFFREY Greporter.nih.gov
Next Generation Brain PET ImagingNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$2,716,869September 1, 2021August 31, 2027ZAHARCHUK, GREGORY GEORGEreporter.nih.gov
Patient-specific thrombosis risk in atrial fibrillation by 4D CT imaging of atrial kinetics combined with computational fluid dynamicsNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,715,396September 1, 2021August 31, 2025KAHN, ANDREWreporter.nih.gov
Biomarkers of Cerebral Cavernous Angioma with Symptomatic Hemorrhage (CASH)NIHNational Institute of Neurological Disorders and Stroke2021 to 2024$2,709,036July 15, 2020April 30, 2026AWAD, ISSAM Areporter.nih.gov
Metabolic and Hormonal Mechanisms of VCIDNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$2,707,906April 15, 2019August 31, 2029ZULOAGA, KRISTEN LEANNEreporter.nih.gov
Role of Endothelial K+ Channels in Age-Related DementiaNIHNational Institute on Aging2022 to 2025$2,707,384May 1, 2022April 30, 2027BEHRINGER, ERIK J.reporter.nih.gov
Aromatic Amino Acids, Microbiome-Generated Metabolites, and Incident Subclinical and Clinical CVD and MortalityNIHNational Heart, Lung, and Blood Institute2024 to 2025$2,706,539July 1, 2017January 31, 2028MOZAFFARIAN, DARIUSHreporter.nih.gov
StAtins Use in intRacereberal hemorrhage patieNts MRI (SATURN MRI) Ancillary StudyNIHNational Institute of Neurological Disorders and Stroke2021$2,705,364August 15, 2021July 31, 2025SELIM, MAGDY Hreporter.nih.gov
Using Brain Lesions and Deep Brain Stimulation to Identify an Epilepsy CircuitNIHNational Institute of Neurological Disorders and Stroke2022 to 2025$2,705,167July 1, 2022March 31, 2027FOX, MICHAEL Dreporter.nih.gov
Optimizing oscillatory epidural electrical stimulation to selectively increase task-related population dynamics in motor areasNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$2,699,391September 30, 2020August 31, 2025GANGULY, KARUNESHreporter.nih.gov
Advanced therapeutic hypothermia efficacy network modeling in neonatal HIENIHEunice Kennedy Shriver National Institute of Child Health & Human Development2022 to 2025$2,692,898September 2, 2022July 31, 2027NORTHINGTON, FRANCES Jreporter.nih.gov
Modulating Exercise Dosage to Improve Concussion Rehabilitation: A Randomized Clinical TrialNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2022 to 2025$2,688,941May 15, 2022March 31, 2027HOWELL, DAVID R.reporter.nih.gov
Utility of memantine in preventing cognitive dysfunction in children receiving cranial radiotherapyNIHNational Cancer Institute2022 to 2025$2,688,046September 18, 2019December 31, 2026LAACK, NADIA Nreporter.nih.gov
Establishment of a Human Microphysiological System to Elucidate Cellular Mechanisms Underlying Vulnerability to ADNIHNational Institute of Neurological Disorders and Stroke2025$2,683,965May 1, 2025April 30, 2028YOUNG-PEARSE, TRACY Lreporter.nih.gov
3D-Nanoprinted Soft Robotic Microcatheters with Integrated Microfluidic Circuitry for Cerebrovascular SurgeryNIHNational Institute of Biomedical Imaging and Bioengineering2022 to 2025$2,683,863August 1, 2022April 30, 2027SOCHOL, RYAN DANIELreporter.nih.gov
Understanding the Contribution of Altered Cerebrovascular Function to the Pathology and Clinical Symptoms of Huntington DiseaseNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$2,681,561December 15, 2020May 31, 2027ROSAS, HERMINIA DIANAreporter.nih.gov
Consortium Of MRI Biomarkers In Neonatal Encephalopathy (COMBINE)NIHNational Institute of Neurological Disorders and Stroke2022 to 2024$2,676,551May 1, 2022April 30, 2025GRANT, PATRICIA ELLENreporter.nih.gov
1/2 Pomalidomide for Bleeding in Patients with Hereditary Hemorrhagic Telangiectasia (HHT)NIHNational Heart, Lung, and Blood Institute2021 to 2023$2,676,312March 15, 2020February 28, 2026MCCRAE, KEITH R.reporter.nih.gov
Interpericyte tunneling nanotubes as new therapeutic targets for neurovascular recovery and vision restoration in glaucoma.NIHNational Eye Institute2025$2,674,763September 30, 2025September 29, 2028DI POLO, ADRIANAreporter.nih.gov
MR-Derived Cerebral Oxygen Metabolism underlying Ischemic Vulnerability in Sickle Cell DiseaseNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,672,673August 15, 2015June 30, 2025FORD, ANDRIA LEEreporter.nih.gov
Intraventricular Hemorrhage Disrupts the Blood Brain Barrier in Premature InfantsNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$2,672,389March 1, 2021February 28, 2026BALLABH, PRAVEENreporter.nih.gov
Seizures and Children's Outcomes after Stroke (SCOUTS)NIHNational Institute of Neurological Disorders and Stroke2022 to 2025$2,672,011January 1, 2022December 31, 2026FOX, CHRISTINE K.reporter.nih.gov
Central Nervous System Derived Exosomes: A Novel Source of Biomarkers for Neonatal Hypoxic Ischemic EncephalopathyNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2022 to 2025$2,664,241June 23, 2022March 31, 2027GOETZL, LAURAreporter.nih.gov
Amyloid-mediated cognitive dysfunction in bacterial pneumonia after TBINIHNational Institute on Aging2025$2,663,195September 15, 2025August 31, 2029WAGENER, BRANT Mreporter.nih.gov
Dissecting the role of CD8+ T cells in atherosclerosisNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,662,899August 20, 2020May 31, 2025GIANNARELLI, CHIARAreporter.nih.gov
Enhancing gamma band response to improve working memory in individuals with mild cognitive impairmentNIHNational Institute on Aging2021 to 2024$2,658,625April 1, 2020March 31, 2026SINGH, FIZAreporter.nih.gov
Quantitative Susceptibility Mapping for Stroke Risk Prediction of Vulnerable Carotid PlaquesNIHNational Institute of Neurological Disorders and Stroke2022 to 2025$2,652,752April 15, 2022March 31, 2027NGUYEN, THANH Dreporter.nih.gov
Neurophotonic Advances for Mechanistic Investigation of the Role of Capillary Dysfunction in Stroke RecoveryNIHNational Institute of Neurological Disorders and Stroke2022 to 2025$2,650,876September 27, 2022August 31, 2027BOAS, DAVID Areporter.nih.gov
Validation of Adenylosuccinate as a Novel Endogenous Pro-Angiogenic Factor in the BrainNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$2,650,791May 15, 2021April 30, 2026GOLOVKO, MIKHAIL Yreporter.nih.gov
Supplement: Stalled capillary flow affects protein clearance by modulating interstitial fluid flowNIHNational Institute on Aging2021 to 2022$2,646,437May 15, 2015April 30, 2024SCHAFFER, CHRIS Breporter.nih.gov
Underlying Mechanisms in CADASILNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,643,847April 20, 2021March 31, 2026IRUELA-ARISPE, M. LUISAreporter.nih.gov
High Sensitivity Diffuse Optical Tomography of Human Brain FuncitonNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$2,642,789August 1, 2009November 30, 2026CULVER, JOSEPH Preporter.nih.gov
24-hour Activity Cycles to Optimize Cognitive Resilience to Alzheimer's Disease in African Americans: The Jackson Heart StudyNIHNational Institute on Aging2021 to 2023$2,629,362September 15, 2020May 31, 2026GABRIEL, KELLEY PETTEEreporter.nih.gov
Early Life Phthalate Exposures in Relation to Structural and Functional Brain DevelopmentNIHNational Institute of Environmental Health Sciences2021 to 2025$2,629,070August 13, 2021May 31, 2027ENGEL, STEPHANIEreporter.nih.gov
Development and validation of novel models for cerebral small vessel disease and vascular cognitive impairmentNIHNational Institute of Neurological Disorders and Stroke2021 to 2023$2,624,637September 18, 2019August 31, 2025GOULD, DOUGLASreporter.nih.gov
Validation of Imaging and Blood-based Small Vessel VCID Biomarkers in Multiethnic PopulationNIHNational Institute of Neurological Disorders and Stroke2021$2,623,751September 30, 2016July 31, 2023WANG, DANNY JJreporter.nih.gov
Validation of small vessel vascular contributions to cognitive impairment and dementia (VCID) biomarkersNIHNational Institute of Neurological Disorders and Stroke2021$2,619,994September 30, 2016July 31, 2023LU, HANZHANGreporter.nih.gov
Divergent age-dependent peripheral innate immune response following TBINIHNational Institute of Neurological Disorders and Stroke2021 to 2025$2,619,872July 1, 2021June 30, 2027THEUS, MICHELLE LEEreporter.nih.gov
Novel Ultrasound Indices of Intracranial Pressure and Brain Ischemia in Neonatal HydrocephalusNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$2,613,622September 30, 2020April 30, 2030HWANG, MISUNreporter.nih.gov
The Comparative Effectiveness and Safety of Oral Anticoagulants in Patients with Cirrhosis and Atrial FibrillationNIHNational Heart, Lung, and Blood Institute2023 to 2025$2,604,074March 1, 2023February 29, 2028SIMON, TRACEYreporter.nih.gov
Neurovascular unit dysfunction in Down syndrome revealed by TBINIHNational Institute of Neurological Disorders and Stroke2022$2,601,812September 7, 2022August 31, 2025HUANG, MINGXIAreporter.nih.gov
Diversity Supplement for Jenny LutshumbaNIHNational Institute on Aging2023 to 2024$2,600,455September 1, 2023August 31, 2026STOWE, ANN MARIEreporter.nih.gov
Slow wave sleep (SWS) and the effect of African ancestry on amyloid burden, a longitudinal studyNIHNational Institute on Aging2021 to 2022$2,599,842September 1, 2018May 31, 2025OSORIO, RICARDO Sreporter.nih.gov
Cerebral Microvascular Signaling and Neurovascular Coupling: An Integrated Approach to Investigate VCIDNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$2,597,866August 1, 2021June 30, 2026TSOUKIAS, NIKOLAOS MICHAELreporter.nih.gov
Development of upper extremity behavioral assessment methods for reach-and-grasp and physical rehabilitationNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2022 to 2025$2,596,675September 21, 2022June 30, 2027HEATHCOCK, JILL C.reporter.nih.gov
Flow Acceleration for Stroke Thrombolysis (FAST) SystemNIHNational Institute of Neurological Disorders and Stroke2021 to 2022$2,595,730July 15, 2021December 31, 2023CREIGHTON, FRANCIS MILTONreporter.nih.gov
Sex differences in the contribution of cerebrovascular injury and immune activation to neurocognitive impairment in HIV infectionNIHNational Institute of Neurological Disorders and Stroke2022 to 2025$2,594,711May 15, 2022February 28, 2027CHOW, FELICIA C.reporter.nih.gov
Role of Peripheral Immune Cells in Cognitive Aging: The Framingham Offspring StudyNIHNational Institute on Aging2021 to 2024$2,594,669April 15, 2020March 31, 2026MURABITO, JOANNE Mreporter.nih.gov
Human 3D Neuro-Vascular Interaction and Meningeal Lymphatic Models with Application to Alzheimer’s DiseaseNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$2,593,927May 1, 2021April 30, 2026KAMM, ROGER Dreporter.nih.gov
Blood-Brain Barrier Disruption as a Biomarker for Perioperative Neurocognitive Disorder:Cognitive Recovery after Elective SurgeryNIHNational Institute on Aging2021 to 2024$2,592,630May 1, 2019February 28, 2026DAIELLO, LORI Areporter.nih.gov
Pericytes and postnatal alveolarization: Role of hypoxia inducible factorsNIHNational Heart, Lung, and Blood Institute2022 to 2025$2,591,893May 1, 2022April 30, 2026CORNFIELD, DAVID N.reporter.nih.gov
Platelet Expression of FcgammaRIIa and Arterial Hemodynamics to Predict Recurrent Stroke in Intracranial AtherosclerosisNIHNational Institute of Neurological Disorders and Stroke2022 to 2025$2,591,032April 1, 2022October 31, 2025LIEBESKIND, DAVID SIGMUNDreporter.nih.gov
Concomitant sensory stimulation during therapy to enhance hand functional recovery post strokeNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2021 to 2024$2,587,878August 1, 2020July 31, 2025SEO, NA JINreporter.nih.gov
Gulf Regional Area Stroke Program and OklahomaNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$2,587,547August 15, 2018November 30, 2028SAVITZ, SEAN Ireporter.nih.gov
Improving Pediatric Cardiac Arrest Survival and Neurologic OutcomeNIHNational Heart, Lung, and Blood Institute2021 to 2023$2,587,303April 1, 2019March 31, 2025KILBAUGH, TODD JUSTENreporter.nih.gov
Advanced MRI biomarkers in HD mouse models translatable to humans: nature history and response to therapeuticsNIHNational Institute of Neurological Disorders and Stroke2022 to 2025$2,585,010August 1, 2022July 31, 2027DUAN, WENZHENreporter.nih.gov
Modulating Low-Frequency Cortical Population Dynamics to Augment Motor Function After StrokeNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$2,578,284April 1, 2020March 31, 2025GANGULY, KARUNESHreporter.nih.gov
Development of quantitative optical tools to continuously monitor cerebral autoregulation, blood flow, oxygenation and inflammation during pediatric extracorporeal life supportNIHNational Institute of Neurological Disorders and Stroke2022 to 2025$2,576,974March 15, 2022February 28, 2027BUSCH, DAVID RICHARDreporter.nih.gov
Brain networks for reading in stroke alexia and typical agingNIHNational Institute on Deafness and Other Communication Disorders2022 to 2025$2,576,034September 1, 2022August 31, 2028TURKELTAUB, PETER ETHANreporter.nih.gov
Using AI on Routine Clinical and Imaging Data from Acute Stroke Encounter to Predict Post-Stroke Vascular Contributions to Cognitive Impairment (AI - RESPECT)NIHNational Institute of Neurological Disorders and Stroke2024 to 2025$2,575,013September 1, 2024July 31, 2027HU, XIAOreporter.nih.gov
Integrating complementary learning principles in aphasia rehabilitation via adaptive modelingNIHNational Institute on Deafness and Other Communication Disorders2022 to 2025$2,574,319February 15, 2022January 31, 2027EVANS, WILLIAM STREICHERreporter.nih.gov
Molecular Identity and Physiological Function of Novel Chloride ChannelsNIHNational Institute of General Medical Sciences2021 to 2025$2,574,122August 1, 2017July 31, 2027QIU, ZHAOZHUreporter.nih.gov
Investigating the Role and the therapeutic potential of Perlecan in experimental vascular dementiaNIHNational Institute of Neurological Disorders and Stroke2024$2,573,724June 12, 2024April 30, 2027BIX, GREGORY JAYEreporter.nih.gov
Neural circuit basis for neurovascular couplingNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$2,572,256February 15, 2021January 30, 2027ROSS, SARAH ELIZABETHreporter.nih.gov
Transferring Speed of Processing Gains to Everyday Cognitive Tasks after StrokeNIHNational Institute on Aging2021 to 2024$2,570,286September 5, 2021August 31, 2025USWATTE, GITENDRAreporter.nih.gov
Neural Basis of Language in Acute Stroke and RecoveryNIHNational Institute on Deafness and Other Communication Disorders2021 to 2025$2,568,295July 1, 2002April 30, 2029HILLIS, ARGYE E.reporter.nih.gov
Global Research Endeavors to Advance Treatment of Neurological Disorders in Africa (GREAT Neurology)NIHNational Institute of Neurological Disorders and Stroke2021 to 2025$2,561,391May 1, 2021April 30, 2029BIRBECK, GRETCHEN L.reporter.nih.gov
Pericyte control of capillary perfusion in the Alzheimer's disease brainNIHNational Institute on Aging2023 to 2025$2,557,000April 15, 2023January 31, 2028SHIH, ANDY Yreporter.nih.gov
Neuropathology and inflammation in a nonhuman primate model of insulin resistance/metabolic syndromeNIHNational Institute on Aging2024 to 2025$2,556,565February 15, 2024November 30, 2028HAVEL, PETER Jreporter.nih.gov
Multimodal Optical Imaging on the Effect of Maternal Polysubstance Exposure on Fetal Brain Microvessel FunctionNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2022 to 2025$2,556,302January 1, 2016July 31, 2027LARIN, KIRILL Vreporter.nih.gov
Imaging Neonatal Hypoxic Ischemic InjuryNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2021 to 2025$2,550,672June 20, 2024May 31, 2029ZHANG, JIANGYANGreporter.nih.gov
Impact of SARS-CoV-2 on the cerebrovasculature as a risk factor for VCID: Role of Wnt/beta-cateninNIHNational Institute of Neurological Disorders and Stroke2025$2,549,080August 11, 2025July 31, 2029LUTZ, SARAH ELIZABETHreporter.nih.gov
Novel Imaging and Biofluid Biomarkers of Small Vessel Cerebrovascular DiseaseNIHNational Institute of Neurological Disorders and Stroke2021$2,547,585September 30, 2016July 31, 2023KRAMER, JOEL Hreporter.nih.gov
Citalopram as a posterior cortical protective therapy in Parkinson diseaseNIHNational Institute on Aging2021 to 2024$2,545,093August 15, 2020April 30, 2026KOTAGAL, VIKASreporter.nih.gov
A South Carolina ECHO Pregnancy CohortNIHOffice of the Director, National Institutes of Health2023 to 2024$2,534,604September 1, 2023May 31, 2025HUNT, KELLY Jreporter.nih.gov
Non-Invasive Imaging Markers to Elicit the Role of Vascular Involvement in Alzheimer’s DiseaseNIHNational Institute on Aging2022 to 2025$2,534,541February 15, 2022January 31, 2027JOHNSON, KEVIN MICHAELreporter.nih.gov
The role of brain border-associated macrophages in aging and cerebral amyloid angiopathyNIHNational Institute on Aging2022 to 2025$2,534,516January 15, 2022December 31, 2026LAFAILLE, JUANreporter.nih.gov
BRAIN HEALTH TOGETHER: A LIVE-STREAMING GROUP-BASED DIGITAL PROGRAMNIHNational Institute on Aging2021 to 2023$2,534,108September 30, 2021November 30, 2024BENJAMIN, CYNTHIA LOUISEreporter.nih.gov
Speech Entrainment for Aphasia Recovery (SpARc)NIHNational Institute on Deafness and Other Communication Disorders2021 to 2023$2,533,747September 1, 2019August 31, 2025WILMSKOETTER, JANINAreporter.nih.gov
Effects of NAD restoration on neurovascular coupling in community dwelling older adultsNIHNational Institute on Aging2022 to 2025$2,531,921August 15, 2022April 30, 2027YABLUCHANSKIY, ANDRIYreporter.nih.gov
Error-enhanced Learning & Recovery in 2 & 3 DimensionsNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$2,531,912July 1, 2007May 31, 2026PATTON, JAMES LANPHIERreporter.nih.gov
Activated protein C mechanisms of brain white matter protection and new therapies for brain white matter ischemic injuryNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$2,531,008July 15, 2020April 30, 2026MACK, WILLIAM Jreporter.nih.gov
DIZZiness Treatment through ImplementatioN & Clinical strategy Tactics (DIZZTINCT-2) ProjectNIHNational Institute on Deafness and Other Communication Disorders2021 to 2024$2,524,276August 1, 2013August 31, 2025KERBER, KEVIN ANTHONYreporter.nih.gov
Vascular Contributions to Cognitive Impairment after Adverse Pregnancy Outcomes: the nuMoM2b-Heart Health StudyNIHNational Institute of Neurological Disorders and Stroke2021 to 2023$2,523,397July 15, 2021June 30, 2027MILLER, ELIZA Creporter.nih.gov
Capillary malformation: From somatic GNAQ mutations to disrupted endothelial biologyNIHNational Heart, Lung, and Blood Institute2021 to 2023$2,522,214April 1, 2016June 30, 2026BISCHOFF, JOYCE E.reporter.nih.gov
Investigation of arterial changes in the Circle of Willis during intracranial aneurysm growth in humansNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,522,073June 1, 2020May 31, 2026CHIEN, AICHIreporter.nih.gov
Sex-specific cognitive expression and risk in preclinical Alzheimer's diseaseNIHNational Institute on Aging2021 to 2023$2,519,693September 15, 2019May 31, 2025BANKS, SARAHreporter.nih.gov
Myosin Light Chain Dephosphorylation by PPP1R12C Promotes Atrial Hypocontractility and Atrial FibrillationNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,519,314April 1, 2020March 31, 2026MCCAULEY, MARK Dreporter.nih.gov
Unraveling the role of tPA in the neurovascular unitNIHNational Heart, Lung, and Blood Institute2021 to 2025$2,518,315August 1, 1995March 31, 2028LAWRENCE, DANIEL Areporter.nih.gov
STAT3 activation in astrocytes as a driver of neurovascular dysfunction in Alzheimer's disease and related dementiasNIHNational Institute of Neurological Disorders and Stroke2022 to 2023$2,515,763September 19, 2022August 31, 2025LIPPMANN, ETHANreporter.nih.gov
Mechanistic Relationships Between Fibrosis, Fibrillation, and Stroke: Multi-Scale, Multi-Physics SimulationsNIHNational Heart, Lung, and Blood Institute2022 to 2025$2,511,001May 5, 2022April 30, 2027BOYLE, PATRICK Mreporter.nih.gov
Effects of global brain health on sensorimotor recovery after strokeNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$2,507,791April 1, 2020March 31, 2026LIEW, SOOK-LEIreporter.nih.gov
Molecular probes to image and target the neurovascular unit in health and diseaseNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$2,505,709December 1, 2019November 30, 2025GRUTZENDLER, JAIMEreporter.nih.gov
Use of Healthcare Across the Full Continuum of Cognitive Health and Decline in Older AdultsNIHNational Institute on Aging2022 to 2025$2,505,518September 30, 2022June 30, 2027GRODSTEIN, FRANCINEreporter.nih.gov
Direct and Indirect Effects of GDF11 in the Aging Central Nervous SystemNIHNational Institute on Aging2021 to 2024$2,503,680September 15, 2020May 13, 2025RUBIN, LEE Lreporter.nih.gov
Supplement to TRANScranial direct current stimulation for POst-stroke motor Recover - a phase II sTudy (TRANSPORT 2)NIHNational Institute of Neurological Disorders and Stroke2022 to 2023$2,503,127August 1, 2019July 31, 2025FENG, WUWEIreporter.nih.gov
Global Blood-Brain Barrier Disruption and Post-Stroke Cognitive DeclineNIHNational Institute of Neurological Disorders and Stroke2022 to 2025$2,499,958April 1, 2022August 31, 2027LEIGH, RICHARDreporter.nih.gov
A Novel Blood Substitution Approach Treats Acute Ischemia in the Aged BrainNIHNational Institute on Aging2025$2,498,714September 1, 2024May 31, 2029REN, XUEFANG SOPHIEreporter.nih.gov
A South Carolina ECHO Pregnancy CohortNIHOffice of the Director, National Institutes of Health2025$2,496,021September 1, 2023May 31, 2030HUNT, KELLY Jreporter.nih.gov
Assessing brain perfusion using IPEN during intra-arterial stroke interventionNIHNational Institute of Neurological Disorders and Stroke2022 to 2025$2,492,194March 1, 2022February 28, 2027TAGUCHI, KATSUYUKIreporter.nih.gov
Fetal cerebral arteries and prenatal alcohol exposureNIHNational Institute on Alcohol Abuse and Alcoholism2022 to 2025$2,492,106March 15, 2022January 31, 2027BUKIYA, ANNAreporter.nih.gov
A Novel Thrombolytic Targeting Von Willebrand Factor (VWF) to Treat Ischemic StrokeNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$2,490,659July 15, 2021June 30, 2027NIMJEE, SHAHIDreporter.nih.gov
Early Detection of Mild Cognitive Impairment, Alzheimer's Disease and Other Dementias using EHRNIHNational Institute on Aging2021 to 2025$2,490,121September 15, 2020May 31, 2027SOHN, SUNGHWANreporter.nih.gov
Imaging Cerebral Small Vessels in Vascular Cognitive Impairment and Dementia (VCID)NIHNational Institute on Aging2023$2,487,668September 1, 2023August 31, 2026WANG, DANNY JJreporter.nih.gov
Exploiting sex-dependent brain injury response for nanoparticle therapeuticsNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$2,482,558January 1, 2021November 30, 2025STABENFELDT, SARAH Ereporter.nih.gov
Gene therapy for disorders of the extracellular matrixNIHNational Institute of Neurological Disorders and Stroke2023$2,481,348April 1, 2023March 31, 2026GOULD, DOUGLASreporter.nih.gov
Customizable cooperative multi-joint control to enhance walking mobility after strokeNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2022 to 2025$2,481,207September 15, 2022June 30, 2027MAKOWSKI, NATHANIEL STEVENreporter.nih.gov
Genetic dissection of trait variation between long-diverged mouse speciesNIHNational Institute of Neurological Disorders and Stroke2021 to 2023$2,481,029September 30, 2019June 30, 2025BREM, RACHEL BETHreporter.nih.gov
Plasticizing the cortex to enhance stroke recoveryNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$2,473,526May 1, 2023April 30, 2026LEE, JIN-MOOreporter.nih.gov
Longitudinal validation of cerebral small vessel disease biomarkers in diverse community-based older adults without dementiaNIHNational Institute of Neurological Disorders and Stroke2021$2,472,997September 1, 2016July 31, 2023ARFANAKIS, KONSTANTINOSreporter.nih.gov
Pericyte structural plasticity and cerebrovascular healthNIHNational Institute on Aging2021 to 2024$2,472,340May 15, 2020February 28, 2026SHIH, ANDY Yreporter.nih.gov
Role of Mast cells in Alzheimer's DiseaseNIHNational Institute on Aging2021 to 2024$2,471,520April 15, 2020February 28, 2026LIBBY, PETERreporter.nih.gov
Implementation of a Stroke Protocol for Emergency Evaluation and Disposition (HI-SPEED)NIHNational Institute of Neurological Disorders and Stroke2023 to 2025$2,471,415August 7, 2023July 31, 2028PRABHAKARAN, SHYAMreporter.nih.gov
Outcomes of non-vitamin K anticoagulants in atrial fibrillationNIHNational Heart, Lung, and Blood Institute2021 to 2023$2,469,549April 1, 2020December 31, 2024RAY, WAYNE Areporter.nih.gov
Bridging the Gap from Hemodynamic Stress to Intracranial Aneurysm Instability: An Integrated Multimodal ApproachNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$2,468,416July 1, 2021April 30, 2027KANEKO, NAOKIreporter.nih.gov
Neuroprotection by nNOS inhibitors in perinatal hypoxia-ischemiaNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$2,467,775May 1, 2020February 28, 2026TAN, SIDHARTHAreporter.nih.gov
Blood test to aid treatment decisions for perinatal asphyxiationNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$2,467,152January 1, 2020September 30, 2025STENGELIN, MARTINreporter.nih.gov
Reducing African Americans' Alzheimer's Disease Risk Through Exercise (RAATE)NIHNational Institute on Aging2021 to 2025$2,465,845February 15, 2019November 30, 2025NEWTON, ROBERT LEEreporter.nih.gov
Mechanisms of paired vagus nerve stimulation in human chronic strokeNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2024 to 2025$2,464,501September 19, 2024April 30, 2026SCHAMBRA, HEIDIreporter.nih.gov
Leveraging Electronic Health Records and artificial IntelligeNce to improve Dementia Screening and early Detection in primary care (LEARN-DSD)NIHNational Institute on Aging2023 to 2025$2,462,815September 21, 2023July 31, 2028RAZAVIAN, NARGESreporter.nih.gov
Brain lymphatic activation for craniosynostosis and Alzheimer’s diseaseNIHNational Institute of Neurological Disorders and Stroke2024$2,461,369June 1, 2024May 31, 2027CHEN, JIANFUreporter.nih.gov
Brain Drain: In Vivo Optical Interrogation of Venular Function in Gray and White MatterNIHNational Institute on Aging2022$2,459,487May 15, 2022April 30, 2025SHIH, ANDY Yreporter.nih.gov
Angiogenic Therapy: Novel Approaches to Enhance Bone Regeneration in Aging - AD/ADRDNIHNational Institute on Aging2021 to 2023$2,458,774April 1, 2019January 31, 2025KACENA, MELISSA Areporter.nih.gov
Neurovascular calcification, Alzheimer’s disease and related dementias in two Native South American populationsNIHNational Institute on Aging2023$2,452,559June 1, 2023May 31, 2026IRIMIA, ANDREIreporter.nih.gov
The SDOH-Homecare Intervention Focus Team (SHIFT) Trial to Mitigate SDOH in Stroke Outcomes and Build Community CapacityNIHNational Institute of Neurological Disorders and Stroke2024 to 2025$2,449,923February 1, 2024January 31, 2029WILLIAMS, OLAJIDEreporter.nih.gov
Velocity-Selective Arterial Spin Labeling based Perfusion Mapping for Alzheimer's diseaseNIHNational Institute on Aging2023$2,448,470May 1, 2023April 30, 2026QIN, QINreporter.nih.gov
Predictability in complex object controlNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2022 to 2025$2,447,622September 24, 2015January 31, 2027STERNAD, DAGMARreporter.nih.gov
Aging, macrophage mediators, and burn trauma: SupplementNIHNational Institute on Aging2021 to 2024$2,445,102February 1, 2001May 31, 2026KOVACS, ELIZABETH J.reporter.nih.gov
Preventing Neurovascular Matrix Degradation and Hemorrhage in Acute Ischemic StrokeNIHNational Heart, Lung, and Blood Institute2022 to 2023$2,444,197September 24, 2019February 28, 2025JEONG, SUN YONGreporter.nih.gov
Quantitative MRI-based cerebral oxygen metabolism in Alzheimer's diseaseNIHNational Institute on Aging2023 to 2025$2,442,647September 30, 2023June 30, 2028WANG, YIreporter.nih.gov
Vascular contributions to HIV-associated Neurocognitive Disorders (HAND)NIHNational Institute on Aging2022 to 2024$2,441,402August 1, 2022July 31, 2027GUTIERREZ, JOSEreporter.nih.gov
Development of perivascular space mapping toolset as a diagnostic aid for Alzheimer's diseaseNIHNational Institute on Aging2024 to 2025$2,439,170August 1, 2024July 31, 2027CHOUPAN, JEIRANreporter.nih.gov
The role of ATP13A5 ATPase in determining blood-brain pericyte functionsNIHNational Institute of Neurological Disorders and Stroke2023$2,438,887September 19, 2023August 31, 2026ZHAO, ZHENreporter.nih.gov
Disparities in Patterns of Recurrent Stroke in the ElderlyNIHNational Institute on Aging2021 to 2025$2,431,056April 1, 2018April 30, 2027LICHTMAN, JUDITH Hreporter.nih.gov
Role of Microglia in Cerebral Small Vessel Disease (CSVD)/Vascular Cognitive Impairment (VCI)NIHNational Institute of Neurological Disorders and Stroke2022 to 2025$2,430,570July 15, 2022June 30, 2027WEINSTEIN, JONATHAN Rreporter.nih.gov
Revitalizing Cognition in Older Adults at Risk for Alzheimer's Disease with Near-Infrared PhotobiomodulationNIHNational Institute on Aging2021 to 2023$2,427,515August 1, 2019April 30, 2026BOWERS, DAWNreporter.nih.gov
Transcranial Near Infrared Radiation and Cerebral Blood Flow in Depression (TRIADE)NIHNational Institute of Mental Health2023 to 2025$2,426,941April 1, 2020January 31, 2027IOSIFESCU, DAN VLADreporter.nih.gov
Quantitative Imaging of Brain Glymphatic Function in HumansNIHNational Institute on Aging2021 to 2024$2,426,232April 15, 2020February 28, 2026DONAHUE, MANUS Jreporter.nih.gov
MESA-CEND: Promoting diversity in Alzheimer’s disease researchNIHNational Institute on Aging2021 to 2022$2,424,017August 15, 2021July 31, 2024DEEP, GAGANreporter.nih.gov
Effects of ventricular volume and cerebral connectivity on neurological outcomes in preterm intraventricular hemorrhageNIHNational Institute of Neurological Disorders and Stroke2022 to 2025$2,422,922March 1, 2022January 31, 2027SMYSER, CHRISTOPHER DANIELreporter.nih.gov

Organizations

OrganizationPlaceNIH awardsNIH amountNSF awardsNSF amount
Columbia University Health SciencesNew York, NY66$236.1 million0$0
Johns Hopkins UniversityBaltimore, MD101$178.4 million0$0
University of Wisconsin-MadisonMadison, WI43$164.8 million0$0
Massachusetts General HospitalBoston, MA117$163.1 million0$0
University of Pittsburgh at PittsburghPittsburgh, PA93$125 million0$0
University of California, San FranciscoSan Francisco, CA87$115 million0$0
Northern California Institute/res/eduSan Francisco, CA11$105.7 million0$0
University of California at DavisDavis, CA32$102 million0$0
University of Southern CaliforniaLos Angeles, CA48$99.4 million0$0
University of CincinnatiCincinnati, OH33$98.8 million0$0
University of California, San DiegoLa Jolla, CA51$89.2 million0$0
Emory UniversityAtlanta, GA43$82.5 million0$0
Washington UniversitySaint Louis, MO60$81.9 million0$0
University of Texas HLTH Sci CTR HoustonHouston, TX72$79.9 million0$0
Vanderbilt University Medical CenterNashville, TN27$79.7 million0$0
University of Michigan at Ann ArborAnn Arbor, MI54$77.2 million0$0
New York University School of MedicineNew York, NY35$76.7 million0$0
Yale UniversityNew Haven, CT57$76.2 million0$0
Northwestern University at ChicagoChicago, IL44$73.9 million0$0
University of Miami School of MedicineCoral Gables, FL37$63.9 million0$0
Rush University Medical CenterChicago, IL21$63.8 million0$0
Duke UniversityDurham, NC50$63.7 million0$0
University of KentuckyLexington, KY38$60.5 million0$0
Weill Medical Coll of Cornell UnivNew York, NY37$59.8 million0$0
University of WashingtonSeattle, WA49$55.8 million0$0
Medical University of South CarolinaCharleston, SC32$55.8 million0$0
University of South FloridaTampa, FL20$55.3 million0$0
Wake Forest University Health SciencesWinston-Salem, NC15$54.7 million0$0
Tulane University of LouisianaNew Orleans, LA26$54.7 million0$0
Mayo Clinic RochesterRochester, MN24$53.7 million0$0
University of Colorado DenverAurora, CO39$53.7 million0$0
Brigham and Women's HospitalBoston, MA29$52.7 million0$0
Stanford UniversityStanford, CA41$50.9 million0$0
University of FloridaGainesville, FL21$50.7 million0$0
University of Alabama at BirminghamBirmingham, AL19$47.4 million0$0
University of California-IrvineIrvine, CA27$45 million0$0
University of California Los AngelesLos Angeles, CA30$44.7 million0$0
University of Texas HLTH Science CenterSan Antonio, TX16$43.9 million0$0
University of California-BerkeleyBerkeley, CA13$42.4 million0$0
University of PennsylvaniaPhiladelphia, PA43$42.4 million0$0
University of Maryland BaltimoreBaltimore, MD27$40.6 million0$0
University of ArizonaTucson, AZ20$40 million0$0
University of MinnesotaMinneapolis, MN29$39.9 million0$0
Boston University Medical CampusBoston, MA26$37.3 million0$0
Cleveland Clinic Lerner Com-CwruCleveland, OH23$35.2 million0$0
Oregon Health & Science UniversityPortland, OR31$33.6 million0$0
University of RochesterRochester, NY28$32.7 million0$0
Univ of North Carolina Chapel HillChapel Hill, NC23$29.9 million0$0
University of Vermont & ST Agric CollegeBurlington, VT18$28.6 million0$0
Icahn School of Medicine at Mount SinaiNew York, NY15$27.4 million0$0
Ut Southwestern Medical CenterDallas, TX16$26.9 million0$0
University of UtahSalt Lake City, UT24$26.7 million0$0
Albert Einstein College of MedicineBronx, NY15$26.6 million0$0
University of Illinois at ChicagoChicago, IL29$26.3 million0$0
University of New Mexico Health Scis CTRAlbuquerque, NM17$25.9 million0$0
Albany Molecular Research, Inc.Albany, NY1$25.7 million0$0
West Virginia University Research CorporationMorgantown, WV13$23.7 million0$0
University of VirginiaCharlottesville, VA21$23.2 million0$0
Vanderbilt UniversityNashville, TN24$23 million0$0
Mayo Clinic JacksonvilleJacksonville, FL6$23 million0$0
Case Western Reserve UniversityCleveland, OH15$22.7 million0$0
Augusta UniversityAugusta, GA22$21.9 million0$0
Baylor College of MedicineHouston, TX15$21.3 million0$0
Massachusetts Institute of TechnologyCambridge, MA13$21.2 million0$0
Ohio State UniversityColumbus, OH19$21.1 million0$0
Trustees of Boston UniversityBoston, MA22$20.7 million0$0
University of South Carolina at ColumbiaColumbia, SC9$20.7 million0$0
SUNY at Stony BrookStony Brook, NY17$20.7 million0$0
Boston Children's HospitalBoston, MA16$20 million0$0
Indiana University IndianapolisIndianapolis, IN21$19.7 million0$0
University of Tennessee Health Sci CTRMemphis, TN18$19.6 million0$0
Temple Univ of the CommonwealthPhiladelphia, PA17$19.1 million0$0
Beth Israel Deaconess Medical CenterBoston, MA8$18.7 million0$0
Virginia Polytechnic Institute and State UniversityBlacksburg, VA10$18.3 million0$0
Pennsylvania State Univ Hershey Med CTRHershey, PA11$17.8 million0$0
University of IowaIowa City, IA15$17.7 million0$0
Seattle Children's HospitalSeattle, WA13$17.4 million0$0
University of Oklahoma HLTH Sciences CTROklahoma City, OK15$15.9 million0$0
J. David Gladstone InstitutesSan Francisco, CA8$15.5 million0$0
University of ChicagoChicago, IL8$15.2 million0$0
Chapman UniversityOrange, CA5$14.9 million0$0
Children's Hosp of PhiladelphiaPhiladelphia, PA9$14.7 million0$0
SUNY Downstate Medical CenterBrooklyn, NY2$14.6 million0$0
Cornell UniversityIthaca, NY8$14.4 million0$0
Rutgers Biomedical and Health SciencesNewark, NJ13$13.2 million0$0
Wayne State UniversityDetroit, MI8$12.6 million0$0
Cedars-Sinai Medical CenterLos Angeles, CA9$12.6 million0$0
Georgetown UniversityWashington, DC14$12.4 million0$0
Loma Linda UniversityLoma Linda, CA11$12.4 million0$0
Rehabilitation Institute of Chicago D/b/a Shirley Ryan AbilitylabChicago, IL10$12.1 million0$0
Pennsylvania State Univ University ParkUniversity Park, PA6$11.3 million0$0
Georgia Tech Research CorporationAtlanta, GA7$11.3 million0$0
Regenerative Research FoundationAlbany, NY3$10.8 million0$0
University of TX MD Anderson Can CTRHouston, TX6$10.6 million0$0
Medical College of WisconsinMilwaukee, WI14$10.1 million0$0
Board of Regents, NSHE, obo University of Nevada, RenoReno, NV5$10 million0$0
University of Rhode IslandKingston, RI9$10 million0$0
University of Texas at DallasRichardson, TX7$9.9 million0$0
Harvard Medical SchoolBoston, MA7$9.7 million0$0
Henry Ford Health SystemDetroit, MI11$9.1 million0$0

Funding by fiscal year

Fiscal yearNIH awardsNIH amountNSF awardsNSF amount
20251,403$1,024,508,7580$0
20241,546$1,068,037,6030$0
20231,542$1,095,989,4010$0
20221,483$995,662,5240$0
20211,455$934,957,8240$0

Open federal funding opportunities

From Grants.gov: notices that funded awards in this table, and open notices on the same agency and assistance listing.

Open opportunityNumberAgencyListingClosesAward ceilingWhy it matches
Change of Recipient Organization (Type 7 Parent Clinical Trial Optional)PA-24-254NIHJuly 12, 2027Not listedNotice number printed on 24 awards here
Mentored Patient-Oriented Research Career Development Award (Parent K23 Independent Clinical Trial Not Allowed)PA-24-185NIHMay 7, 2027Not listedNotice number printed on 4 awards here
Mentored Clinical Scientist Research Career Development Award (Parent K08 Independent Clinical Trial Not Allowed)PA-24-182NIHMay 8, 2027Not listedNotice number printed on 3 awards here
Mentored Research Scientist Development Award (Parent K01 - Independent Clinical Trial Not Allowed)PA-24-176NIHMay 7, 2027Not listedNotice number printed on 1 award here
NIH Pathway to Independence Award (Parent K99/R00 Independent Clinical Trial Not Allowed)PA-24-194NIHMay 7, 2027Not listedNotice number printed on 1 award here
Midcareer Investigator Award in Patient-Oriented Research (Parent K24 Independent Clinical Trial Not Allowed)PA-24-188NIHMay 7, 2027Not listedNotice number printed on 1 award here
Mentored Research Scientist Development Award (Parent K01 - Independent Clinical Trial Required)PA-24-175NIHMay 7, 2027Not listedNotice number printed on 1 award here
Functional Target Validation for Alzheimer's Disease-Related DementiasRFA-NS-26-034NIH93.853November 6, 2026Not listedSame assistance listing 93.853 as 1,346 awards here
Clinical Trials and Ancillary Studies Conducted within NIH-Funded Clinical Trial Research Networks (UG3/UH3 - Clinical Trial Required)PAR-27-007NIH93.853November 10, 2026Not listedSame assistance listing 93.853 as 1,346 awards here
Amyotrophic Lateral Sclerosis (ALS) Intermediate Patient Population Expanded Access (U01 Clinical Trial Required)RFA-NS-26-001NIH93.853November 10, 2026Not listedSame assistance listing 93.853 as 1,346 awards here
Ethical, Legal and Social Implications (ELSI) Exploratory/Developmental Research Grant (R21 Clinical Trial Optional)PAR-25-369NIH93.853November 18, 2026Not listedSame assistance listing 93.853 as 1,346 awards here
Ethical, Legal and Social Implications (ELSI) Research (R01 Clinical Trial Optional)PAR-25-371NIH93.853November 18, 2026Not listedSame assistance listing 93.853 as 1,346 awards here
NIH StrokeNet Clinical Trials and Biomarker Studies for Stroke Treatment, Recovery, and Prevention (UG3/UH3 Clinical Trial Optional)PAR-25-052NIH93.853November 19, 2026Not listedSame assistance listing 93.853 as 1,346 awards here
HEAL Initiative: Pain Research Enhancement Program (PREP) (R15 Clinical Trial Optional)RFA-AT-25-003NIH93.853November 23, 2026$375,000Same assistance listing 93.853 as 1,346 awards here
Maximizing the Scientific Value of Data Generated by the Environmental Influences on Child Health Outcomes (ECHO) Program: Ruth L. Kirschstein National Research Service Award (NRSA) Individual Postdoctoral Fellowship (F32)RFA-OD-27-008NIH93.853December 2, 2026Not listedSame assistance listing 93.853 as 1,346 awards here
Emerging Global Leader Award (K43 Independent Clinical Trial Required)PAR-24-295NIH93.853December 3, 2026Not listedSame assistance listing 93.853 as 1,346 awards here
Emerging Global Leader Award (K43 Independent Clinical Trial Not Allowed)PAR-24-296NIH93.853December 3, 2026Not listedSame assistance listing 93.853 as 1,346 awards here
NIH Research Software Engineer (RSE) Award (R50 Clinical Trials Not Allowed)RFA-OD-24-011NIH93.853December 4, 2026Not listedSame assistance listing 93.853 as 1,346 awards here
Academic Research Enhancement Award (AREA) for Undergraduate-Focused Institutions (R15 Clinical Trial Required)PAR-24-214NIH93.853January 7, 2027$375,000Same assistance listing 93.853 as 1,346 awards here
HEAL Initiative: Studies to Enable Analgesic Discovery (R61/R33 - Clinical Trial Not Allowed)RFA-NS-25-023NIH93.853January 15, 2027$350,000Same assistance listing 93.853 as 1,346 awards here

Updated November 4, 2026. Read from NIH RePORTER ExPORTER and NSF Award Search. Published by NIH and NSF as U.S. government data. NIH awards are fiscal years 2021 to 2025 (NIH files published to 2026-07-09); NSF awards are fiscal years 2022 to 2026 (NSF files published to 2026-11-04). NIH amounts are the total cost of each fiscal year in the window; NSF amounts are the funds obligated in the window. Organizations are matched on the UEI. Open opportunities come from Grants.gov and match on agency and assistance listing number, and on the notice number NIH prints on an award. Free to reuse with credit to SpecStream under CC BY 4.0. Spot a wrong value? Write to [email protected] with the link to this page.