Data / Research funding / Batten Disease
Batten Disease: 38 NIH awards ($37.7M) to 22 organizations
38 NIH awards ($37.7M) in the NIH spending category Batten Disease, to 22 organizations, read 2026-11-03. NIH fiscal years 2021 to 2025.
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Awards
38 awards in the window.
| Award | Agency | Institute or division | Fiscal year | Amount in window | Start | End | Principal investigator | Source |
|---|---|---|---|---|---|---|---|---|
| Development of N-tert-(butyl)hydroxylamine (NtBuHA) as a therapeutic agent for treating CLN1 Batten Disease | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2025 | $4,136,457 | September 20, 2021 | June 30, 2027 | CHELSKY, DANIEL | reporter.nih.gov |
| Manufacture of an intracerebroventricular Enzyme Replacement Therapy for CLN1 Batten Disease | NIH | National Institute of Neurological Disorders and Stroke | 2024 to 2025 | $3,953,139 | March 8, 2024 | February 28, 2026 | EKINS, SEAN | reporter.nih.gov |
| Manufacture of an intracerebroventricular Enzyme Replacement Therapy for CLN1 Batten Disease | NIH | National Institute of Neurological Disorders and Stroke | 2022 to 2023 | $2,999,846 | September 15, 2018 | May 31, 2025 | EKINS, SEAN | reporter.nih.gov |
| Small Molecule Drug Discovery for CLN3 and CLN6 Disease | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2021 to 2025 | $2,584,107 | September 20, 2021 | June 30, 2027 | TRIPPIER, PAUL | reporter.nih.gov |
| Meaningful Outcomes and Multi-Site Readiness for Clinical Trials in Juvenile Neuronal Ceroid Lipofuscinosis | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2024 | $2,064,399 | April 1, 2019 | January 31, 2025 | AUGUSTINE, ERIKA | reporter.nih.gov |
| Characterizing and testing the efficacy of AAV-mediated gene therapy in a sheep model of CLN1 disease. | NIH | National Institute of Neurological Disorders and Stroke | 2022 to 2025 | $1,898,833 | August 1, 2022 | June 30, 2027 | COOPER, JONATHAN D | reporter.nih.gov |
| Reading Frame Correction for the Treatment of Batten Disease | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2023 | $1,746,388 | May 1, 2020 | May 15, 2023 | HASTINGS, MICHELLE L | reporter.nih.gov |
| Gene therapy for preserving the visual system in lysosomal storage diseases | NIH | National Eye Institute | 2021 to 2024 | $1,577,131 | May 1, 2021 | March 31, 2026 | KATZ, MARTIN L | reporter.nih.gov |
| Sustained delivery of therapeutics to the visual system using genetically modified autologous mesenchymal stem cells to treat blinding diseases | NIH | National Eye Institute | 2021 to 2023 | $1,519,053 | May 1, 2019 | April 30, 2025 | WHITING, REBECCA EH | reporter.nih.gov |
| Network modulation to improve gene therapy in CLN3 disease | NIH | National Institute of Neurological Disorders and Stroke | 2023 to 2025 | $1,462,821 | September 18, 2023 | July 31, 2027 | AHRENS-NICKLAS, REBECCA CLARE | reporter.nih.gov |
| Structure and mechanism of the mitochondrial ATP synthase and Batten Disease gene product, Cln3p | NIH | National Institute of General Medical Sciences | 2021 to 2023 | $1,334,132 | August 1, 2019 | July 31, 2025 | MUELLER, DAVID MICHAEL | reporter.nih.gov |
| Novel Lysosomal Enzyme Deficient in Batten Disease | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2022 | $994,783 | April 1, 1998 | May 31, 2023 | SLEAT, DAVID EDWARD | reporter.nih.gov |
| Determining the role of CLN3 in the eye | NIH | National Eye Institute | 2021 to 2022 | $949,115 | April 1, 2019 | January 31, 2025 | SINGH, RUCHIRA | reporter.nih.gov |
| Extracellular Vesicles for CNS Delivery of Therapeutic Enzymes to Treat Lysosomal Storage Disorders | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2023 | $892,704 | September 1, 2019 | June 30, 2024 | BATRAKOVA, ELENA | reporter.nih.gov |
| Hematopoietic stem cell gene therapy for infantile neuronal ceroid lipofuscinosis | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2021 to 2022 | $717,826 | August 21, 2018 | April 30, 2023 | WILLIAMS, DAVID A | reporter.nih.gov |
| Cellular Mechanisms of Enteric Nervous System Damage in CLN2 Disease | NIH | National Institute of Neurological Disorders and Stroke | 2025 | $643,377 | July 15, 2025 | June 30, 2030 | COOPER, JONATHAN D | reporter.nih.gov |
| Mechanisms Of Er-To-Golgi Transport Of Lysosomal Enzymes | NIH | National Institute of General Medical Sciences | 2021 to 2022 | $630,000 | February 1, 2019 | July 31, 2023 | SARDIELLO, MARCO | reporter.nih.gov |
| Alzheimer's Disease: simultaneous modulation of NMDAR, BACE1, APP and Fyn activity by palmitoylation-targeting CIRC825 | NIH | National Institute on Aging | 2021 | $507,284 | July 15, 2021 | December 31, 2023 | WILEY, DEVIN THOMAS | reporter.nih.gov |
| Characterizing and testing the efficacy of AAV-mediated gene therapy in a novel CRISPR/Cas9 generated sheep model of Cln1 disease. | NIH | National Institute of Neurological Disorders and Stroke | 2021 | $502,428 | July 1, 2021 | June 30, 2022 | COOPER, JONATHAN D | reporter.nih.gov |
| Novel Lysosomal Enzyme Deficient in Batten Disease | NIH | National Institute of Neurological Disorders and Stroke | 2023 | $497,524 | April 1, 1998 | May 31, 2024 | SLEAT, DAVID EDWARD | reporter.nih.gov |
| The role of CSPalpha in Adult onset neuronal Lipofuscinosis pathogenesis | NIH | National Institute of Neurological Disorders and Stroke | 2022 | $490,512 | September 20, 2022 | August 31, 2025 | BENITEZ, BRUNO A. | reporter.nih.gov |
| Network modulation to improve gene therapy in CLN3 disease | NIH | National Institute of Neurological Disorders and Stroke | 2022 | $471,780 | August 1, 2022 | July 31, 2023 | AHRENS-NICKLAS, REBECCA CLARE | reporter.nih.gov |
| A Small Molecule Enzyme Replacement for the Treatment of CLN1 | NIH | National Institute of Neurological Disorders and Stroke | 2021 | $467,091 | August 15, 2021 | July 31, 2024 | RUDD, ANDREW | reporter.nih.gov |
| Title: Development and Validation of Therapy for GM1 Gangliosidosis | NIH | National Institute of Neurological Disorders and Stroke | 2023 | $461,701 | September 15, 2023 | August 31, 2025 | BROWN, JILLIAN R | reporter.nih.gov |
| Investigating the role of CSPalpha in presynaptic autophagy | NIH | National Institute on Aging | 2025 | $461,313 | June 1, 2025 | May 31, 2027 | CHANDRA, SREEGANGA S | reporter.nih.gov |
| Exploring the Pathogenic Mechanisms of Batten's disease MFSD8 mutations using patient iPSC derived neurons. | NIH | National Institute of Neurological Disorders and Stroke | 2022 to 2023 | $440,000 | April 1, 2022 | March 31, 2025 | MAZZULLI, JOSEPH R | reporter.nih.gov |
| Defining and treating peripheral nervous system dysfunction in Cln1 disease | NIH | National Institute of Neurological Disorders and Stroke | 2022 to 2023 | $433,125 | April 1, 2022 | March 31, 2025 | COOPER, JONATHAN D | reporter.nih.gov |
| High-resolution multi-modal ultrasound imaging of brain development in Batten disease models | NIH | National Institute of Biomedical Imaging and Bioengineering | 2022 to 2023 | $421,083 | September 7, 2022 | June 30, 2025 | DOYLEY, MARVIN M | reporter.nih.gov |
| Elucidating and harnessing the molecular mechanisms of protective clearance in endogenous and engineered phagocytes | NIH | National Institute of Neurological Disorders and Stroke | 2023 | $418,606 | September 8, 2023 | August 31, 2026 | WILLIAMSON, ADAM PATRICK | reporter.nih.gov |
| Mechanisms of neuronal network dysfunction in juvenile neuronal ceroid lipofuscinosis | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2022 | $376,056 | September 30, 2018 | August 31, 2023 | AHRENS-NICKLAS, REBECCA CLARE | reporter.nih.gov |
| Cellular mechanism of Adult Onset Neuronal Ceroid Lipofuscinosis (ANCL) caused by mutations in cysteine string protein-alpha (CSPalpha). | NIH | National Institute of Neurological Disorders and Stroke | 2021 | $364,288 | April 1, 2017 | March 31, 2025 | SHARMA, MANU | reporter.nih.gov |
| Modulation of lysosomal function for the treatment of Batten disease | NIH | National Institute of Neurological Disorders and Stroke | 2021 | $344,531 | September 30, 2012 | July 31, 2023 | SARDIELLO, MARCO | reporter.nih.gov |
| Development of a protein palmitoylation assay to monitor treatment of CLN1 Batten Disease | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2021 | $304,787 | September 15, 2021 | February 28, 2024 | SCOTT, ANNA INGRID | reporter.nih.gov |
| Understanding human lysosomal-autophagic dysfunction in CLN6 with IPSC-derived neural cells | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2021 | $208,750 | March 1, 2020 | February 28, 2022 | PIERSON, TYLER MARK | reporter.nih.gov |
| Method for Detection and Quantification of CLN3 Protein | NIH | National Institute of Neurological Disorders and Stroke | 2021 | $153,000 | July 1, 2021 | June 30, 2024 | WANG, QINGJUN | reporter.nih.gov |
| Understanding interplay between the Hsp70 chaperone code and Cyclin D1/Cln3 | NIH | National Cancer Institute | 2025 | $150,784 | September 1, 2025 | August 31, 2027 | TRUMAN, ANDREW WILLIAM | reporter.nih.gov |
| Molecular characterization of lipofuscin pathology in neuronal ceroid lipofuscinosis | NIH | National Institute of Neurological Disorders and Stroke | 2023 to 2024 | $81,658 | December 16, 2022 | December 15, 2024 | TIEZE, SOFIA MASSARO | reporter.nih.gov |
| Mechanism and rescue of lysosomal defects in Adult-onset Neuronal Ceroid Lipofuscinosis | NIH | National Institute of Neurological Disorders and Stroke | 2025 | $49,538 | September 22, 2025 | July 22, 2027 | MCDONOUGH, SAMANTHA R | reporter.nih.gov |
Organizations
Funding by fiscal year
| Fiscal year | NIH awards | NIH amount | NSF awards | NSF amount |
|---|---|---|---|---|
| 2025 | 9 | $5,989,881 | 0 | $0 |
| 2024 | 7 | $4,348,839 | 0 | $0 |
| 2023 | 17 | $8,071,950 | 0 | $0 |
| 2022 | 19 | $9,642,032 | 0 | $0 |
| 2021 | 21 | $9,657,248 | 0 | $0 |
Open federal funding opportunities
From Grants.gov: notices that funded awards in this table, and open notices on the same agency and assistance listing.
Updated November 3, 2026. Read from NIH RePORTER ExPORTER and NSF Award Search. Published by NIH and NSF as U.S. government data. NIH awards are fiscal years 2021 to 2025 (NIH files published to 2026-07-09); NSF awards are fiscal years 2022 to 2026 (NSF files published to 2026-11-02). NIH amounts are the total cost of each fiscal year in the window; NSF amounts are the funds obligated in the window. Organizations are matched on the UEI. Open opportunities come from Grants.gov and match on agency and assistance listing number, and on the notice number NIH prints on an award. Free to reuse with credit to SpecStream under CC BY 4.0. Spot a wrong value? Write to [email protected] with the link to this page.