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Data / Research funding / Autoimmune Disease

Autoimmune Disease: 3,837 NIH awards ($4.8B) to 494 organizations

3,837 NIH awards ($4.8B) in the NIH spending category Autoimmune Disease, to 494 organizations, read 2026-11-03. NIH fiscal years 2021 to 2025.

SpecStream is the live web data engine for teams and agents. It reads the NIH and NSF award files each time the agencies update them, and this page is that reading, joined to the open federal funding opportunities on Grants.gov. Ask for the awards you track by topic, organization or state and new awards arrive in your sheet, CRM, Slack or agent as the agencies publish them.

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NIH spending category

Awards

The 500 largest of 3,837 awards in the window.

AwardAgencyInstitute or divisionFiscal yearAmount in windowStartEndPrincipal investigatorSource
Immune Tolerance NetworkNIHNational Institute of Allergy and Infectious Diseases2021 to 2025$203,912,588February 1, 2014January 31, 2028BUCKNER, JANE HOYTreporter.nih.gov
Data Coordinating Center for Type 1 Diabetes TrialNetNIHNational Institute of Diabetes and Digestive and Kidney Diseases2022 to 2025$99,686,705September 30, 2015May 31, 2030KRISCHER, JEFFREY Preporter.nih.gov
Limited Competition: Continued Follow-up of Subjects and Initiation of a Second Case-control Cohort in The Environmental Determinants of Diabetes in The Young Study (TEDDY)NIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2025$73,059,202April 28, 2021December 31, 2026KRISCHER, JEFFREY Preporter.nih.gov
Regulation of B cell Responses in SLE and Other Autoimmune DiseasesNIHNational Institute of Allergy and Infectious Diseases2021 to 2025$53,786,694May 1, 2014April 30, 2029SANZ, IGNACIO E.reporter.nih.gov
DRCR Retina NetworkNIHNational Eye Institute2021 to 2025$43,226,123September 30, 2002December 31, 2028GLASSMAN, ADAM Rreporter.nih.gov
Human Pancreas Analysis Program for Type 1 Diabetes - HPAP-T1DNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2025$37,867,556September 20, 2016June 30, 2029NAJI, ALIreporter.nih.gov
Epidemiology of Diabetes Interventions and Complications (EDIC) StudyNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2025$35,015,476September 22, 2011June 30, 2027GUBITOSI-KLUG, ROSE Areporter.nih.gov
IPP: AUTOIMMUNE DISEASES STATISTICAL AND CLINICAL COORDINATING CENTER (ADSCCC)NIHNational Institute of Allergy and Infectious Diseases2022 to 2025$32,128,916February 1, 2025January 31, 2026MILLIN, CHRISTINAreporter.nih.gov
RhoFED CDSMCNIHNational Institute of Allergy and Infectious Diseases2023 to 2025$28,374,518May 8, 2023April 30, 2028SCHMIDT, PETER N.reporter.nih.gov
Follow-up on Subjects, Integrative Data Analysis and Measurement of Viral Antibodies in The Environmental Determinants of Diabetes in The Young Study (TEDDY)NIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2022$19,999,721April 13, 2020March 31, 2024KRISCHER, JEFFREY Preporter.nih.gov
Accelerating Medicines Partnership-Autoimmune and Immunologic Disease Tissue Research CoreNIHNational Institute of Arthritis and Musculoskeletal and Skin Diseases2022 to 2025$19,601,747March 23, 2022December 31, 2026GUTHRIDGE, JOEL MARVINreporter.nih.gov
Center for Quantitative Biology: A focus on "omics", from organisms to single cellsNIHNational Institute of General Medical Sciences2021 to 2025$17,122,562August 1, 2019June 30, 2029WHITFIELD, MICHAEL Lreporter.nih.gov
Data Coordinating Center for the Type 1 Diabetes in Acute Pancreatitis ConsortiumNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2025$17,043,926September 17, 2020July 31, 2025CHINCHILLI, VERNON Mreporter.nih.gov
A Phase-2b, Double-Blind, Randomized Controlled Trial to Evaluate the Activity and Safety of Inebilizumab in Anti-N-methyl-D-aspartate receptor (NMDAR) Encephalitis and Assess Markers of DiseaseNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$15,144,108September 15, 2021August 31, 2027CLARDY, STACEY LYNNreporter.nih.gov
Anti-NMDA Receptor Antibodies in Adult Brain Dysfunction: Lessons from LupusNIHNational Institute of Allergy and Infectious Diseases2021 to 2025$14,990,990August 1, 2008June 30, 2030DIAMOND, BETTYreporter.nih.gov
Integrated Islet Distribution Program (U24) - 2021NIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2025$14,918,013September 30, 2012July 31, 2027NILAND, JOYCE CAROLreporter.nih.gov
Advancing cross-disease comparisons through FAIR data practices to uncover shared molecular mechanisms between Alzheimer's disease and autoimmune disordersNIHNational Institute on Aging2021 to 2025$14,514,376September 1, 2025April 30, 2027HEATH, LAURA MICHELLEreporter.nih.gov
University of Michigan Data Coordinating Center for the Diabetic Foot ConsortiumNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2025$13,554,809July 1, 2019December 31, 2027SPINO, CATHERINE Areporter.nih.gov
Diabetes-Docs: Physician-Scientist Career Development Program (DiabDocs)NIHNational Institute of Diabetes and Digestive and Kidney Diseases2022 to 2025$13,003,302July 8, 2022June 30, 2027MAAHS, DAVID MATTHEWreporter.nih.gov
Functional Microbiomics, Inflammation and PathogenicityNIHNational Institute of General Medical Sciences2021 to 2025$12,492,994March 1, 2018February 29, 2028LAMONT, RICHARD Jreporter.nih.gov
Tissue destruction and healing in Celiac DiseaseNIHNational Institute of Diabetes and Digestive and Kidney Diseases2022 to 2025$9,512,977September 15, 2022July 31, 2027JABRI, BANAreporter.nih.gov
Clinical, Imaging, and Endoscopic Outcomes of Children Newly Diagnosed with Crohn's DiseaseNIHNational Institute of Diabetes and Digestive and Kidney Diseases2023 to 2025$8,401,766April 1, 2023March 31, 2028HYAMS, JEFFREY SAMUELreporter.nih.gov
Central Hub for Kidney Precision MedicineNIHNational Institute of Diabetes and Digestive and Kidney Diseases2024 to 2025$8,320,420July 1, 2024June 30, 2027HIMMELFARB, JONATHANreporter.nih.gov
Immunotherapy for Ocular Surface DiseasesNIHNational Eye Institute2021 to 2025$8,312,140February 1, 2021December 31, 2026JAIN, SANDEEPreporter.nih.gov
KPMP Kidney Mapping and Atlas Project (KMAP)NIHNational Institute of Diabetes and Digestive and Kidney Diseases2022 to 2025$8,070,448September 20, 2022June 30, 2027KRETZLER, MATTHIASreporter.nih.gov
Precision IBD via genetics and genomics: integrating International and multi-omic datasets, expanding studies in diverse populations, and defining mechanisms of unmet clinical needs in IBDNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2025$7,890,535September 30, 2002June 30, 2027CHO, JUDY H.reporter.nih.gov
Renewal of the Human Islet Research Enhancement Center (HIREC) for the Type-1-Diabetes-Focused Human Islet Research Network (HIRN).NIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2025$7,703,361September 15, 2014June 30, 2029KADDIS, JOHN S.reporter.nih.gov
Diabetes Research CenterNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2025$7,571,345December 1, 1996December 31, 2027KAHN, STEVEN EMANUELreporter.nih.gov
The Biostatistics Research Center for the Impaired Awareness of Hypoglycemia ConsortiumNIHNational Institute of Diabetes and Digestive and Kidney Diseases2022 to 2025$7,517,806September 25, 2022December 31, 2027CHINCHILLI, VERNON Mreporter.nih.gov
Hyperbaric Oxygen Therapy for Ulcerative Colitis Patients Hospitalized for Moderate to Severe Flares: A Phase 3 Multi-Center, Randomized, Double-Blind, Sham-Controlled TrialNIHNational Institute of Diabetes and Digestive and Kidney Diseases2023 to 2025$7,269,328March 15, 2023February 29, 2028DULAI, PARAMBIR SINGHreporter.nih.gov
Identifying Immune and Epithelial Network Signatures in Very Early Onset Inflammatory Bowel DiseaseNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2024$7,187,152September 15, 2020June 30, 2026SNAPPER, SCOTT Breporter.nih.gov
Biorepository and Coordinating Center for Studies on Cardiovascular Complications of Human Type 1 DiabetesNIHNational Institute of Diabetes and Digestive and Kidney Diseases2022 to 2025$7,099,019August 1, 2022May 31, 2027ATKINSON, MARK A.reporter.nih.gov
SYSTEM ADMINISTRATION AND MANAGEMENT SUPPORT FOR BIOMEDICAL AND BIBLIOGRAPHIC INFORMATION RESOURCESNIHNational Cancer Institute2023 to 2025$6,614,179September 28, 2023September 27, 2026FREELAND, KATHRYNreporter.nih.gov
The Cleveland Digestive Diseases Research Core Center (DDRCC)NIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2025$6,425,666February 15, 2015August 31, 2030COMINELLI, FABIOreporter.nih.gov
Clinical-Translational Studies in Skin, Lung, and Vascular Complications in Systemic SclerosisNIHNational Institute of Arthritis and Musculoskeletal and Skin Diseases2022 to 2025$6,366,452September 20, 2022August 31, 2027LAFYATIS, ROBERT A.reporter.nih.gov
Deciphering the Genomics of Gene Network Regulation of T Cell and Fibroblast States in Autoimmune InflammationNIHNational Human Genome Research Institute2021 to 2025$6,348,798August 20, 2021May 31, 2027LESLIE, CHRISTINA Sreporter.nih.gov
Phase II trial of GM-CSF/sargramostim in Alzheimer's DiseaseNIHNational Institute on Aging2021 to 2023$6,265,868February 1, 2021November 30, 2026POTTER, HUNTINGTONreporter.nih.gov
Interferon Signaling in the T1D Islet MicroenvironmentNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2025$6,240,105September 15, 2020August 31, 2029MIRMIRA, RAGHAVENDRA Greporter.nih.gov
Host and microbial basis of human ulcerative colitis and pouchitis: Identification, role, mechanisms, and resource development of host susceptibility and pathobiont factorsNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2023$6,122,586September 1, 2019May 31, 2025CHANG, EUGENE Breporter.nih.gov
Integration of immune cell subtypes across diseases & tissueNIHNational Institute on Aging2021 to 2022$5,948,190September 30, 2018August 31, 2023DE JAGER, PHILIP Lreporter.nih.gov
Metabolic gatekeepers in B-cell malignanciesNIHNational Cancer Institute2021 to 2025$5,936,594April 1, 2016August 31, 2028MÜSCHEN, MARKUSreporter.nih.gov
Spatial and temporal resolution to dissect cellular circuits controlling intestinal physiology, immunity, and inflammatory pathologiesNIHNational Institute of Diabetes and Digestive and Kidney Diseases2023 to 2025$5,934,972August 1, 2023May 31, 2028XAVIER, RAMNIK Jreporter.nih.gov
Identifying Microbial, Epithelial and Immune Cell Interactions that Mediate Mucosal Homeostasis and Determine IBD PhenotypesNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2023$5,810,225September 19, 2013June 30, 2025SARTOR, RYAN Breporter.nih.gov
Sjögren’s Team for Accelerating Medicines Partnership (STAMP)NIHNational Institute of Dental & Craniofacial Research2022 to 2025$5,801,518March 7, 2022December 31, 2026SHIBOSKI, CAROLINE HELENEreporter.nih.gov
The Role of B cells in the Origin and Progression of Multiple SclerosisNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$5,776,308May 1, 2019April 30, 2027HAUSER, STEPHEN Lreporter.nih.gov
Environmental Biosensors in the Oligodendrocyte LineageNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$5,732,603May 15, 2019April 30, 2027CASACCIA, PATRIZIAreporter.nih.gov
SLE Treatment with N-acetylcysteineNIHNational Institute of Arthritis and Musculoskeletal and Skin Diseases2021 to 2025$5,581,470June 15, 2020May 31, 2027PERL, ANDRASreporter.nih.gov
The Columbia PCC for CureGN: the Cure Glomerulonephropathy networkNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2025$5,398,076September 16, 2013May 31, 2029BOMBACK, ANDREW STEPHENreporter.nih.gov
Determinants of inception of inflammation in inflammatory bowel diseasesNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2025$5,397,834August 24, 2021May 31, 2027ANANTHAKRISHNAN, ASHWIN Nreporter.nih.gov
Innate immune sensors, inflammasomes, and inflammasome-mediated processes in cancerNIHNational Cancer Institute2021 to 2025$5,241,422July 21, 2020June 30, 2027KANNEGANTI, THIRUMALA-DEVIreporter.nih.gov
Computational and Experimental Resources for Virome Analysis in Inflammatory Bowel Disease (CERVAID)NIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2023$5,235,383September 18, 2019June 30, 2025WANG, DAVIDreporter.nih.gov
Central Vein Sign: A Diagnostic Biomarker in Multiple SclerosisNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$5,233,917July 1, 2020June 30, 2026ONTANEDA, DANIELreporter.nih.gov
CureGN-Penn PCCNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2025$5,209,008September 16, 2013May 31, 2029HOLZMAN, LAWRENCE B.reporter.nih.gov
Understanding Neurocognition in Youth with Type 1 Diabetes (UNYT1D) Biostatistics Research Center (BRC)NIHNational Institute of Diabetes and Digestive and Kidney Diseases2024 to 2025$5,150,596August 15, 2024June 30, 2029HELGESON, ERIKA S.reporter.nih.gov
Lupus Omics Cutaneous Kidney Investigative Team (LOCKIT)NIHNational Institute of Arthritis and Musculoskeletal and Skin Diseases2022 to 2025$5,148,251March 21, 2022December 31, 2026BUYON, JILL Preporter.nih.gov
Immune Cells and Secretory Pathways Leading to Human Systemic AutoimmunityNIHNational Institute of Allergy and Infectious Diseases2021 to 2025$5,112,288May 1, 2019April 30, 2029PASCUAL, MARIA VIRGINIAreporter.nih.gov
Human gene transfer & macrophage cell transplantation therapy of hereditary PAP (hPAP)NIHNational Heart, Lung, and Blood Institute2023 to 2025$5,061,587May 10, 2021April 30, 2027TRAPNELL, BRUCE Creporter.nih.gov
Methotrexate treatment of Arthritis caused by Chikungunya virus (MARCH): A randomized controlled trial of methotrexate versus placebo in the treatment of chronic arthritis after chikungunya infectionNIHNational Institute of Arthritis and Musculoskeletal and Skin Diseases2022 to 2024$5,036,160September 1, 2022August 31, 2027CHANG, AILEENreporter.nih.gov
Composite porcine islet-kidney xenotransplants to cure diabetes and renal failureNIHNational Institute of Allergy and Infectious Diseases2021 to 2024$5,035,116May 21, 2020April 30, 2026SACHS, DAVID Hreporter.nih.gov
Utility of Random Biopsies in Inflammatory Bowel DiseaseNIHNational Institute of Diabetes and Digestive and Kidney Diseases2024 to 2025$5,031,513July 1, 2024June 30, 2029LEWIS, JAMES Dreporter.nih.gov
Validation of Serum Neurofilament Light Chain as a Prognostic and Monitoring Biomarker in Multiple SclerosisNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$5,027,415January 1, 2020December 31, 2025CALABRESI, PETER Areporter.nih.gov
Determinants of follicular helper T cell expansion in lupusNIHNational Institute of Allergy and Infectious Diseases2022 to 2025$4,994,422July 8, 2020July 31, 2029MOREL, LAURENCEreporter.nih.gov
Targeted DOK7 gene therapy for Congenital Myasthenic SyndromesNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$4,856,116September 15, 2021August 31, 2026SEPULVEDA, PATRICIOreporter.nih.gov
Development of Clinical Prediction Models for Pulmonary Outcomes in SarcoidosisNIHNational Heart, Lung, and Blood Institute2022 to 2025$4,842,777April 1, 2022March 31, 2027KOTH, LAURA Lreporter.nih.gov
Delineating mechanisms of skeletal fragility in older adults with Type 1 DiabetesNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2025$4,798,865February 1, 2021January 31, 2027YU, ELAINE WEI-YINreporter.nih.gov
The Pediatric Lupus Nephritis Mycophenolate Mofetil (PLUMM) StudyNIHNational Institute of Arthritis and Musculoskeletal and Skin Diseases2022 to 2025$4,768,587July 15, 2022April 30, 2027BRUNNER, HERMINE Ireporter.nih.gov
Activation of Macrophages in Human Autoimmune DiseasesNIHNational Institute of Allergy and Infectious Diseases2021 to 2025$4,710,162March 1, 2000July 31, 2029IVASHKIV, LIONEL Breporter.nih.gov
Integrative Network Biology Approaches to Identify, Characterize and Validate Molecular Subtypes in Alzheimer's DiseaseNIHNational Institute on Aging2021 to 2022$4,709,163May 15, 2014August 31, 2023ZHANG, BINreporter.nih.gov
Chemical probes to decipher PAD biologyNIHNational Institute of General Medical Sciences2021 to 2025$4,690,000June 1, 2016May 31, 2026THOMPSON, PAUL Rreporter.nih.gov
PANDA-MSD: Predictive Analytics via Networked Distributed Algorithms for Multi-System DiseasesNIHNational Center for Advancing Translational Sciences2022 to 2025$4,670,835August 5, 2022May 31, 2027CHEN, YONGreporter.nih.gov
Intracellular Innate Immune Receptors in Cancer Suppression and ImmunotherapyNIHNational Cancer Institute2021 to 2025$4,541,273September 17, 2019August 31, 2026TING, JENNY Preporter.nih.gov
CUREGN 3.0 - Pediatric Nephrology Consortium - PCCNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2025$4,521,564September 16, 2013May 31, 2029SMOYER, WILLIAM Ereporter.nih.gov
AIM-for-RANIHNational Institute of Arthritis and Musculoskeletal and Skin Diseases2022 to 2025$4,499,382March 22, 2022December 31, 2026ANOLIK, JENNIFER HOWITTreporter.nih.gov
Unraveling microprotein biology with an evolutionary-immunological frameworkNIHNational Center for Complementary & Integrative Health2023 to 2025$4,468,145September 8, 2023August 31, 2028CARVUNIS, ANNE-RUXANDRAreporter.nih.gov
Unified and fair multimodal representation learning for autoimmune diseasesNIHOffice of the Director, National Institutes of Health2024 to 2025$4,435,452September 16, 2024September 15, 2026SHEIKH, SAIRA Zreporter.nih.gov
JAK Inhibition in Down SyndromeNIHNational Institute of Arthritis and Musculoskeletal and Skin Diseases2022 to 2024$4,419,892September 25, 2019July 31, 2025ESPINOSA, JOAQUIN M.reporter.nih.gov
Neonatal porcine islet xenografts for the treatment of type 1 diabetesNIHNational Institute of Allergy and Infectious Diseases2021 to 2024$4,363,576September 1, 2010June 30, 2025KIRK, ALLAN D.reporter.nih.gov
Human Microphysiology Systems Disease Model of Type 2 Diabetes Starting with Liver and pancreatic IsletsNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2022$4,324,679September 20, 2018July 31, 2023TAYLOR, D. LANSINGreporter.nih.gov
CureGN-3: UNCPCCNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2025$4,280,738September 16, 2013May 31, 2029FALK, RONALD Jreporter.nih.gov
Charting human islet maturation via combined soft nanoelectronics and single-cell spatial transcriptomicsNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2025$4,276,659September 17, 2021May 31, 2027LIU, JIAreporter.nih.gov
Neurovascular Interactions: Mechanisms, imaging, therapeutic potentialNIHNational Institute of Neurological Disorders and Stroke2021 to 2023$4,247,898September 1, 2016August 31, 2025AKASSOGLOU, KATERINAreporter.nih.gov
Predictive drivers of new onset, relapse, and progression of human autoimmunity in skinNIHNational Institute of Allergy and Infectious Diseases2023 to 2025$4,237,221April 20, 2023March 31, 2026HARRIS, JOHN Ereporter.nih.gov
Cytokine regulation of mucosal inflammationNIHNational Institute of Allergy and Infectious Diseases2021 to 2025$4,234,402June 6, 2019June 30, 2029SONNENBERG, GREGORY Freporter.nih.gov
: Clinical Outcomes in Aicardi Goutières SyndromeNIHNational Institute of Neurological Disorders and Stroke2021 to 2023$4,216,994July 1, 2019June 30, 2025VANDERVER, ADELINE LUCIEreporter.nih.gov
Evaluation of Novel Technologies to Improve Clinical Management of Celiac Disease: The GLUTECH TrialNIHNational Institute of Diabetes and Digestive and Kidney Diseases2023 to 2025$4,185,542September 15, 2023June 30, 2028LEBWOHL, BENJAMINreporter.nih.gov
Disease and Race Specific Single-cell Epigenetic Mechanisms in Human SLENIHNational Institute of Allergy and Infectious Diseases2021 to 2025$4,125,381May 1, 2021April 30, 2027GAFFNEY, PATRICK Mreporter.nih.gov
Multi-racial genetic analysis of hidradenitis suppurativaNIHNational Institute of Arthritis and Musculoskeletal and Skin Diseases2021 to 2025$4,095,633July 16, 2021June 30, 2026LIAO, WILSONreporter.nih.gov
Immunologic and Antigenic Drivers of Immune Checkpoint Inhibitor-Associated MyocarditisNIHNational Heart, Lung, and Blood Institute2021 to 2025$4,067,768May 1, 2021April 30, 2027BALKO, JUSTIN Mreporter.nih.gov
Mechanisms of New-Onset Autoimmunity/Longitudinal Immune Systems Analysis (MONA-LISA)NIHNational Institute of Allergy and Infectious Diseases2023 to 2025$4,017,799March 22, 2023February 29, 2028KARP, DAVID Rreporter.nih.gov
Is Obesity an Infectious Disease?: Gut bacterial and fungal translocation as an underappreciated driver of visceral adipose expansion.NIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2025$3,971,090September 30, 2021June 30, 2026DEVKOTA, SUZANNEreporter.nih.gov
Type 1 Diabetes TrialNet Clinical Network HubNIHNational Institute of Diabetes and Digestive and Kidney Diseases2022 to 2025$3,959,999September 9, 2014May 31, 2030GREENBAUM, CARLA Jreporter.nih.gov
High throughput screening assays to identify chemical probes targeting Hectd3, an E3 ubiquitin ligase implicated in multiple sclerosisNIHNational Institute of Allergy and Infectious Diseases2021 to 2025$3,939,372April 15, 2021March 31, 2027LI, HONGMINreporter.nih.gov
Molecular basis of bioelectronic medicineNIHNational Institute of General Medical Sciences2021 to 2025$3,937,630May 1, 2016April 30, 2027TRACEY, KEVIN Jreporter.nih.gov
Harnessing engineered T regulatory cells to promote beta cell health in T1DNIHNational Institute of Diabetes and Digestive and Kidney Diseases2022 to 2025$3,920,533April 8, 2022January 31, 2026BUCKNER, JANE HOYTreporter.nih.gov
ELLIPSS: ELucidating the Landscape of Immunoendotypes in Psoriatic Skin and SynoviumNIHNational Institute of Arthritis and Musculoskeletal and Skin Diseases2022 to 2025$3,900,002March 21, 2022December 31, 2026RITCHLIN, CHRISTOPHER TREVORreporter.nih.gov
Autoimmune Drivers and Protectors Team Science (ADAPTS)NIHNational Institute of Allergy and Infectious Diseases2023 to 2025$3,860,822March 1, 2023February 29, 2028JAMES, JUDITH Areporter.nih.gov
RESOURCE BASED CENTER FOR MUSCULOSKELETAL BIOLOGY AND MEDICINENIHNational Institute of Arthritis and Musculoskeletal and Skin Diseases2021 to 2025$3,860,791April 15, 2019June 30, 2029SILVA, MATTHEW Jreporter.nih.gov
Mechanisms and pathophysiologic impact of claudin-2 modulationNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2025$3,845,865September 29, 2001June 30, 2028TURNER, JERROLD R.reporter.nih.gov
Integrative analysis of multi-omic signatures and cellular function in human pancreas across developmental timeline at single-cell spatial resolutionNIHNational Institute of Diabetes and Digestive and Kidney Diseases2022 to 2025$3,809,484September 20, 2022June 30, 2027BRISSOVA, MARCELAreporter.nih.gov
Mechanisms of autoimmune disease risk in IL2/IL2RA-dependent immune toleranceNIHNational Institute of Allergy and Infectious Diseases2021 to 2025$3,767,518February 23, 2021January 31, 2027WELLS, ANDREW Dreporter.nih.gov
Modulating Glial Fate and Function in Development and DiseaseNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$3,751,910May 1, 2020April 30, 2028TESAR, PAUL JOSEPHreporter.nih.gov
Adalimumab in Juvenile Idiopathic Arthritis-associated Uveitis Stopping TrialNIHNational Eye Institute2021 to 2023$3,733,343May 1, 2019April 30, 2026ACHARYA, NISHAreporter.nih.gov
Studies on the structure of basement membranesNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2025$3,732,265September 1, 1986June 30, 2029HUDSON, BILLY GERALDreporter.nih.gov
Differentiation of Clinical Phenotypes of Inflammatory and Neuropathic Ocular Pain Conditions with Morphologic Measures and Functional Brain ImagingNIHNational Eye Institute2022 to 2025$3,722,281September 30, 2022August 31, 2027MOULTON, ERIC ALANreporter.nih.gov
An interactive resource to generate and provide integrated knowledge of the human pancreasNIHNational Institute of Diabetes and Digestive and Kidney Diseases2024 to 2025$3,713,324February 1, 2024November 30, 2028GAULTON, KYLE JEFFRIEreporter.nih.gov
CNS Pain Mechanisms in Early Rheumatoid Arthritis: Implications for the Acute to Chronic Pain TransitionNIHNational Institute of Arthritis and Musculoskeletal and Skin Diseases2021 to 2025$3,704,355July 1, 2013April 30, 2027LEE, YVONNE CLAIREreporter.nih.gov
Single cell and spatial genomic analyses of specimens from patients with autoimmune diseases (Technology Core)NIHNational Institute of Arthritis and Musculoskeletal and Skin Diseases2022 to 2025$3,700,281March 22, 2022December 31, 2026BRENNER, MICHAEL B.reporter.nih.gov
Rheumatoid Arthritis-Related Autoantibodies, Articular Inflammation, and RA-Associated Interstitial Lung DiseaseNIHNational Institute of Arthritis and Musculoskeletal and Skin Diseases2021 to 2025$3,692,582September 27, 2021June 30, 2027SPARKS, JEFFREY ANDREWreporter.nih.gov
Using ex vivo, in vivo models and patient mutations to interrogate pancreatic exocrine-endocrine cross talkNIHNational Institute of Diabetes and Digestive and Kidney Diseases2022 to 2025$3,664,508September 20, 2022June 30, 2027KULKARNI, ROHIT N.reporter.nih.gov
Reserve against Disability in Early Multiple Sclerosis (RADIEMS) Longitudinal Cohort StudyNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2021 to 2025$3,629,278July 11, 2016July 31, 2026SUMOWSKI, JAMES FRANCISreporter.nih.gov
ADalimumab Vs. conventional ImmunoSupprEssion for uveitis(ADVISE) TrialNIHNational Eye Institute2021 to 2022$3,613,158September 30, 2018August 31, 2025HOLBROOK, JANET T.reporter.nih.gov
Mechanisms associated with flares and remission in colitisNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2025$3,593,722May 1, 2017May 31, 2026LIRA, SERGIO A.reporter.nih.gov
Regulators of immune complex mediated neutrophil antigen presentationNIHNational Heart, Lung, and Blood Institute2021 to 2025$3,580,976September 30, 1999February 28, 2027MAYADAS, TANYA Nreporter.nih.gov
Epigenetics of the autoantibody response in systemic lupusNIHNational Institute of Allergy and Infectious Diseases2021 to 2025$3,576,652September 24, 2021August 31, 2026CASALI, PAOLOreporter.nih.gov
Bioactive Metabolites Modulate Immune-Related Adverse Events in Cancer ImmunotherapyNIHNational Cancer Institute2021 to 2025$3,549,010July 8, 2021February 28, 2027SHARMA, SONIAreporter.nih.gov
Translating Scientific Evidence into Practice using Digital Medicine and Electronic Patient Reported OutcomesNIHNational Center for Advancing Translational Sciences2021 to 2023$3,537,149April 20, 2020March 31, 2025SANDS, BRUCE Ereporter.nih.gov
Intramuscular vs. Enteral Penicillin Prophylaxis to Prevent Progression of Latent Rheumatic Heart Disease: A non-inferiority randomized trial. (GOALIE)NIHNational Heart, Lung, and Blood Institute2024 to 2025$3,518,173February 1, 2023January 31, 2028BEATON, ANDREA ZAWACKIreporter.nih.gov
Insights Into Immune-Related Diseases Born from Population GenomicsNIHNational Institute of Allergy and Infectious Diseases2021 to 2025$3,513,383July 6, 2010July 31, 2030NORMAN, PAUL JOHNreporter.nih.gov
Design and development of HDAC11-specific chemical inhibitors for disease treatmentsNIHNational Institute of Allergy and Infectious Diseases2021 to 2025$3,482,034March 1, 2021February 28, 2027SETO, EDWARDreporter.nih.gov
Disparities in cardiovascular health in young adults with type 1 diabetesNIHNational Heart, Lung, and Blood Institute2024 to 2025$3,472,802September 1, 2024May 31, 2028DABELEA, DANAreporter.nih.gov
Defining mechanisms of disease and repair in a viral model of multiple sclerosisNIHNational Institute of Neurological Disorders and Stroke2022 to 2025$3,467,101May 1, 2020April 30, 2029LANE, THOMAS Ereporter.nih.gov
Role of Transglutaminase 2 in Celiac SprueNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2025$3,463,787September 20, 2003April 30, 2026KHOSLA, CHAITANreporter.nih.gov
Pathogenesis of Neurological Disability in Primary Diseases of MyelinNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$3,460,848December 1, 2016November 30, 2025TRAPP, BRUCE Dreporter.nih.gov
Epigenetic Checkpoint Regulation of Naive T-cell Quiescence and Peripheral ToleranceNIHNational Institute of Allergy and Infectious Diseases2025$3,428,212July 22, 2025June 30, 2029FENG, YONGQIANGreporter.nih.gov
Characterization of Mucosal LymphocytesNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2025$3,410,819September 30, 1992June 30, 2029BLUMBERG, RICHARD Sreporter.nih.gov
The Impact of the Bone Marrow Niche's Immune Privilege on Psoriatic ArthritisNIHNational Institute of Allergy and Infectious Diseases2025$3,406,145August 8, 2025July 31, 2029FUJISAKI, JOJIreporter.nih.gov
CAR-T cell treatment of CNS AutoimmunityNIHNational Institute of Allergy and Infectious Diseases2022 to 2025$3,403,175June 13, 2022May 31, 2027WU, GREGORYreporter.nih.gov
Cholesterol reduction and cardiovascular risk in Type 1 diabetesNIHNational Heart, Lung, and Blood Institute2022 to 2025$3,394,086August 5, 2022July 31, 2027GOLDBERG, IRA Jreporter.nih.gov
Microphysiological systems for modeling autoimmunity in type 1 diabetesNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2023$3,372,768August 2, 2019July 31, 2025STANGER, BEN Zreporter.nih.gov
Functional and Mechanistic Characterization of Lupus SusceptibilityNIHNational Institute of Allergy and Infectious Diseases2025$3,364,935September 3, 2025August 31, 2029NATH, SWAPAN K.reporter.nih.gov
Integration of genomics and transcriptomics to investigate biological pathways in very early onset IBDNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2025$3,353,628July 1, 2021April 30, 2027KELSEN, JUDITH RACHELreporter.nih.gov
Impact of Disparities in Food Security on Glycemic Control and Health CareUtilization Among Youth and Young Adults with DiabetesNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2025$3,349,600April 1, 2018March 31, 2028LIESE, ANGELA Dreporter.nih.gov
The PAS Sensor Family and Human HealthNIHNational Institute of Environmental Health Sciences2021 to 2024$3,342,660September 15, 2017May 31, 2026BRADFIELD, CHRISTOPHER Areporter.nih.gov
Periodontitis Role in Inflammatory Bowel DiseaseNIHNational Institute of Diabetes and Digestive and Kidney Diseases2025$3,340,009September 1, 2025August 31, 2029THUMBIGERE-MATH, VIVEKreporter.nih.gov
Multiscale genome engineering to map cis-regulatory variants in human and mouseNIHNational Human Genome Research Institute2023 to 2025$3,334,063September 15, 2023June 30, 2027SANJANA, NEVILLEreporter.nih.gov
Hydrogels for human beta cell survival, function and evasion of immune rejectionNIHNational Institute of Diabetes and Digestive and Kidney Diseases2022 to 2025$3,331,035September 15, 2022May 31, 2027GARCIA, ANDRES Jreporter.nih.gov
Engineering synthetic immune cells with modular sentinel and therapeutic functions for T1DNIHNational Institute of Diabetes and Digestive and Kidney Diseases2022 to 2025$3,328,254April 1, 2022September 30, 2026LIM, WENDELL Areporter.nih.gov
Engineering 2nd generation 5MCARs to monitor and treat Type-I DiabetesNIHNational Institute of Diabetes and Digestive and Kidney Diseases2022 to 2025$3,325,791April 1, 2022March 31, 2027KUHNS, MICHAEL Sreporter.nih.gov
Apolipoprotein C3-loading of apolipoprotein B100 lipoproteins and cardiovascular disease in patients with type 1 diabetesNIHNational Heart, Lung, and Blood Institute2022 to 2025$3,318,186January 5, 2022December 31, 2026HEINECKE, JAY Wreporter.nih.gov
Impact of Registry Use on Quality and Outcomes in Rheumatology (QORA)NIHNational Institute of Arthritis and Musculoskeletal and Skin Diseases2021 to 2025$3,312,228July 16, 2021May 31, 2027SCHMAJUK, GABRIELAreporter.nih.gov
Enhancer-based Immune and Beta Cell Dysregulation Underlying T1D RiskNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2023$3,303,112September 15, 2020June 30, 2025SUH, YOUSINreporter.nih.gov
The Influence Of Gut Microbiota Stability In Inflammatory Bowel DiseaseNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2025$3,299,380March 4, 2019February 28, 2027FAITH, JEREMIAH JAMESreporter.nih.gov
Pathogenesis of lung injury mediated by lung-restricted antibodiesNIHNational Heart, Lung, and Blood Institute2021 to 2025$3,293,690April 1, 2019March 31, 2027BHARAT, ANKITreporter.nih.gov
Examining IgG4 sialylation as a gain of function post-translation modification in IgG4-related diseasesNIHNational Institute of Allergy and Infectious Diseases2021 to 2024$3,291,872July 1, 2020June 30, 2025ANTHONY, ROBERT MCCULLOUGHreporter.nih.gov
Defining the features of T cell response to tumor and self-antigens as predictors of response to checkpoint therapyNIHNational Cancer Institute2021 to 2024$3,284,686September 1, 2019August 31, 2025BUCKNER, JANE HOYTreporter.nih.gov
Immune modulating therapies to treat complex regional pain syndromeNIHNational Institute of Neurological Disorders and Stroke2022 to 2025$3,283,186September 30, 2022August 31, 2027AJIT, SEENAreporter.nih.gov
Functional outcomes of inflammatory bowel disease associated variantsNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2025$3,272,687September 18, 2013May 31, 2028ABRAHAM, CLARAreporter.nih.gov
Unmodified and Post Translationally Modified CD4+ and CD8+ T cell Epitopes in Rheumatoid ArthritisNIHNational Institute of Allergy and Infectious Diseases2021 to 2023$3,237,408September 30, 2019September 29, 2023BENTON, RYANreporter.nih.gov
Anti-interneuron antibodies in rapid-onset pediatric OCD: clinical generalization and target identificationNIHNational Institute of Mental Health2022 to 2025$3,227,070September 1, 2022June 30, 2027PITTENGER, CHRISTOPHER JOHNreporter.nih.gov
Targeting P2 Receptors to Restore Salivary and Lacrimal Gland Function in Sjogren's SyndromeNIHNational Institute of Dental & Craniofacial Research2021 to 2025$3,216,546March 1, 2021February 28, 2027WEISMAN, GARY ANDREWreporter.nih.gov
Sjögren's International Collaborative Clinical Alliance Next Generation Studies (SICCA-NextGen)NIHNational Institute of Dental & Craniofacial Research2021 to 2024$3,205,764June 1, 2020November 30, 2025SHIBOSKI, CAROLINE HELENEreporter.nih.gov
Early myocardial remodeling and progressive kidney function decline in type 1 diabetesNIHNational Heart, Lung, and Blood Institute2022 to 2025$3,199,007December 24, 2021November 30, 2026DORIA, ALESSANDROreporter.nih.gov
Continuation of Epidemiology of Diabetes Interventions and Complications (EDIC) Study Biostatistics CenterNIHNational Institute of Diabetes and Digestive and Kidney Diseases2022$3,184,520August 15, 2012June 30, 2025BRAFFETT, BARBARA HALINAreporter.nih.gov
The role of BAF related complexes in regulatory T cell development and functionNIHNational Institute of Allergy and Infectious Diseases2021 to 2024$3,171,120June 1, 2020May 31, 2025ZHENG, YEreporter.nih.gov
Autologous BM-MSCs and Islet Co-transplantation to Enhance Islet Survival and Function in TP-IAT PatientsNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2025$3,169,762August 24, 2021May 31, 2027WANG, HONGJUNreporter.nih.gov
Characterization of cardiovascular diseases (CVD) in people with long duration Type 1 diabetesNIHNational Heart, Lung, and Blood Institute2022 to 2025$3,160,264December 24, 2021November 30, 2025KING, GEORGE Lreporter.nih.gov
Mechanistic and therapeutic role of the CD137-CD137L axis in Type 1 DiabetesNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2025$3,158,683July 21, 2016June 30, 2027CHEN, YI-GUANGreporter.nih.gov
Identification and Characterization of Microbial Metabolites in ImmunityNIHNational Institute of Allergy and Infectious Diseases2022 to 2025$3,152,946May 26, 2022April 30, 2027XAVIER, RAMNIK Jreporter.nih.gov
Chemoproteomic-Enabled Strategy to Study SLC Transporter Roles in InflammationNIHNational Institute of Allergy and Infectious Diseases2021 to 2025$3,147,169July 1, 2021June 30, 2026PARKER, CHRISTOPHER Greporter.nih.gov
Harnessing Novel Human Endocrine Progenitor Biology for Enhanced Generation of Beta Cells from Stem CellsNIHNational Institute of Diabetes and Digestive and Kidney Diseases2025$3,140,632September 1, 2025August 31, 2029SNEDDON, JULIE BETHreporter.nih.gov
The Relationship Between Brain Macrophages and Cognitive Dysfunction in Systemic Lupus ErythematosusNIHNational Institute of Allergy and Infectious Diseases2022 to 2025$3,138,464July 5, 2022June 30, 2027CUDA, CARLA Mreporter.nih.gov
Cellular Therapy for Type 1 Diabetes using Mesenchymal Stem CellsNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2025$3,134,067June 1, 2019March 31, 2027WANG, HONGJUNreporter.nih.gov
Resolving the mechanisms of IFIH1 risk variant in systemic lupus erythematosusNIHNational Institute of Allergy and Infectious Diseases2025$3,130,679September 3, 2025August 31, 2029GORMAN, JACQUELYNreporter.nih.gov
Microbiota-immune interactions that promote intestinal homeostasisNIHNational Center for Complementary & Integrative Health2021 to 2025$3,111,145June 15, 2021May 31, 2026ROUND, JUNE LOUISEreporter.nih.gov
Engineering T cells to Promote Islet TransplantNIHNational Institute of Diabetes and Digestive and Kidney Diseases2022 to 2025$3,102,316April 1, 2022March 31, 2027RILEY, JAMES L.reporter.nih.gov
Engineered Immune Cells for T1DNIHNational Institute of Diabetes and Digestive and Kidney Diseases2022 to 2025$3,097,818April 1, 2022March 31, 2026MEYER, EVERETTreporter.nih.gov
Vascularized NICHE with local immunosuppression for cell replacement for Type 1 diabetesNIHNational Institute of Diabetes and Digestive and Kidney Diseases2022 to 2025$3,096,729September 12, 2022May 31, 2027GRATTONI, ALESSANDROreporter.nih.gov
Investigating Mucosal Breaks in the Initiation and Progression of Rheumatoid ArthritisNIHNational Institute of Arthritis and Musculoskeletal and Skin Diseases2021 to 2025$3,091,101June 23, 2021April 30, 2026ROBINSON, WILLIAM Hreporter.nih.gov
An endothelial-fibroblast axis connecting senescence to amino acid metabolism for control of vascular stiffness in PAHNIHNational Heart, Lung, and Blood Institute2022 to 2025$3,085,449September 1, 2014April 30, 2027CHAN, STEPHEN Yreporter.nih.gov
Deciphering the role of noncoding variation in the pathogenesis of multiple sclerosisNIHNational Institute of Allergy and Infectious Diseases2021 to 2025$3,077,928July 15, 2021June 30, 2027CIOFANI, MARIAreporter.nih.gov
Advanced Artificial Pancreas Systems to Enable Fully Automated Glycemic Control in Type 1 Diabetes MellitusNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2025$3,074,490September 12, 2021July 31, 2027BRETON, MARC Dreporter.nih.gov
NIDDK Diabetic Foot Consortium Clinical Research UnitNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2025$3,070,460September 15, 2018December 31, 2027HOLMES, CRYSTAL MURRAYreporter.nih.gov
Autoimmune Encephalitis - Ataxia and Psychiatric Disease: Identifying and Characterizing Novel Antibody TargetsNIHNational Institute of Mental Health2021 to 2024$3,068,428April 16, 2020January 31, 2026WILSON, MICHAEL Rreporter.nih.gov
Innate immune regulation of neuroinflammationNIHNational Institute of Allergy and Infectious Diseases2021 to 2025$3,052,610June 1, 2021May 31, 2027SONNENBERG, GREGORY Freporter.nih.gov
Mechanism of action for the epithelial-specific ER stress sensor IRE1β in regulating intestinal homeostasis and host defenseNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2024$3,050,147September 1, 1993March 31, 2026LENCER, WAYNE Ireporter.nih.gov
PanKbase: a community hub for integrated pancreas knowledgeNIHNational Institute of Diabetes and Digestive and Kidney Diseases2024 to 2025$3,048,518February 1, 2024November 30, 2028PARKER, STEPHEN CJreporter.nih.gov
Building the foundations of commensal vaccinesNIHNational Institute of Allergy and Infectious Diseases2022 to 2025$3,047,222September 23, 2022August 31, 2027FISCHBACH, MICHAEL ANDREWreporter.nih.gov
Dissecting the pathogenesis and outcomes of PSC using multi-omics by studying the exposome and genomeNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2022$3,027,125September 1, 2018July 31, 2025LAZARIDIS, KONSTANTINOS Nreporter.nih.gov
Engineering a Human Microphysiological System for the Characterization of Islet-Immune InteractionsNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2023$3,023,310August 1, 2019July 31, 2025STABLER, CHERIE Lreporter.nih.gov
Extracellular Vesicle-mediated islet immune cross talk in Type 1 Diabetes pathogenesisNIHNational Institute of Diabetes and Digestive and Kidney Diseases2022 to 2025$3,020,296September 15, 2022April 30, 2027REIJONEN, HELENA KRISTIINAreporter.nih.gov
A 3D vascularized islet biomimetic to model type 1 diabetesNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2023$3,017,660August 1, 2019January 31, 2025SANDER, MAIKEreporter.nih.gov
Identifying cell-type specific genetic control of T1D risk variants in TEDDYNIHNational Institute of Diabetes and Digestive and Kidney Diseases2024 to 2025$3,014,326February 1, 2024January 31, 2027ONENGUT, SUNAreporter.nih.gov
Cbfb in RORgt-regulated T cell functionNIHNational Institute of Allergy and Infectious Diseases2021 to 2025$3,010,210May 1, 2014May 31, 2029SUN, ZUOMINGreporter.nih.gov
Improving Glycemia & Reducing Diabetes Distress in Adolescents & Young Adults with T1DNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2024$3,003,444August 25, 2021July 31, 2025LAFFEL, LORI Mreporter.nih.gov
Optimizing detection and prediction of changes in cognitive function in multiple sclerosis with novel ambulatory assessment methodsNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2021 to 2025$3,003,354August 1, 2021July 31, 2027KRATZ, ANNA LOUISEreporter.nih.gov
Characterization of beta-cell-specific extracellular vesicle cargo as functional biomarkers for type I DM diseaseNIHNational Institute of Diabetes and Digestive and Kidney Diseases2022 to 2025$3,000,544September 19, 2022July 31, 2027DAS, SAUMYAreporter.nih.gov
Development of TP-317 in Ulcerative ColitisNIHNational Institute of Diabetes and Digestive and Kidney Diseases2023 to 2025$2,996,955September 18, 2017February 28, 2027PARKINSON, JOHNreporter.nih.gov
Salivary gland ionocyte organization and function during homeostasis, repair, and diseaseNIHNational Institute of Dental & Craniofacial Research2021 to 2025$2,994,334August 18, 2021May 31, 2027MAKARENKOVA, HELEN P.reporter.nih.gov
Manufacturing RNA-based CAR T cells to combat autoantibody-associated autoimmune disorders (AAAD)NIHNational Institute of Neurological Disorders and Stroke2024 to 2025$2,992,236June 7, 2024May 31, 2026STEWART, CHARLES ANDREWreporter.nih.gov
Pyrimidine metabolism in the development of autoreactive B cells and SLENIHNational Institute of Allergy and Infectious Diseases2025$2,989,958September 1, 2025August 31, 2029RAHMAN, ZIAURreporter.nih.gov
The NOTCH Signaling Pathway in Large Vessel VasculitisNIHNational Heart, Lung, and Blood Institute2021 to 2025$2,984,128January 6, 2014June 30, 2027WEYAND, CORNELIA M.reporter.nih.gov
Genetically-engineered stem cells for self-regulating arthritis therapyNIHNational Institute of Arthritis and Musculoskeletal and Skin Diseases2022 to 2025$2,983,611April 1, 2022March 31, 2027GUILAK, FARSHIDreporter.nih.gov
Proteomic analysis of hydroxychloroquine prevention trials in T1D, RA and SLENIHNational Institute of Allergy and Infectious Diseases2023 to 2024$2,978,715August 18, 2023July 31, 2028BUCKNER, JANE HOYTreporter.nih.gov
Role of Systemic Inflammation in Cognitive Decline: Rheumatoid Arthritis as a PrototypeNIHNational Institute on Aging2021 to 2024$2,977,796September 30, 2020May 31, 2026MYASOEDOVA, ELENAreporter.nih.gov
Discriminating the contributions of CCR4 and CCR7 to thymic central toleranceNIHNational Institute of Allergy and Infectious Diseases2021 to 2025$2,972,596March 15, 2014August 31, 2030EHRLICH, LAUREN ILYSE RICHIEreporter.nih.gov
Early detection of type 1 diabetes via Exosome Technology with Optoelectronics Lab-on-chip: EXTOLNIHNational Institute of Diabetes and Digestive and Kidney Diseases2022 to 2025$2,971,174September 15, 2022April 30, 2026LEE, LUKE P.reporter.nih.gov
Discovery and Characterization of Genetic Risk Loci in Sjogren's SyndromeNIHNational Institute of Arthritis and Musculoskeletal and Skin Diseases2021 to 2024$2,957,132September 7, 2020August 31, 2025LESSARD, CHRISTOPHER Jreporter.nih.gov
A Novel IL-35 Expressing Probiotic Platform for Inducing Allergen Specific ToleranceNIHNational Institute of Allergy and Infectious Diseases2021 to 2023$2,952,468May 1, 2020June 30, 2025FANGER, NEIL Areporter.nih.gov
Identifying and preventing antigen specific T cells in diabetesNIHNational Institute of Allergy and Infectious Diseases2021 to 2025$2,951,339June 22, 2021May 31, 2027FIFE, BRIAN Treporter.nih.gov
Neuregulin-4: A Novel Therapy for Inflammatory Bowel DiseaseNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2022$2,942,139September 20, 2016June 30, 2024GHOSH, SOUMITRAreporter.nih.gov
Rheumatoid Arthritis-associated Parenchymal Lung Disease: Clinical and Molecular PhenotypesNIHNational Heart, Lung, and Blood Institute2022 to 2025$2,937,551April 15, 2022March 31, 2027WASHKO, GEORGE Rreporter.nih.gov
Precise targeting of T1D specific T cells using CAR and peptide-MHC chimeric antigen ligandsNIHNational Institute of Diabetes and Digestive and Kidney Diseases2022 to 2025$2,937,157May 15, 2022April 30, 2027WONG, WILSONreporter.nih.gov
A phospho-tyrosine-based signaling module controlling TLR-mediated inflammatory disease.NIHNational Institute of Allergy and Infectious Diseases2022 to 2025$2,936,823July 7, 2022June 30, 2027HAECKER, HANSreporter.nih.gov
Investigation and Treatment of Undiagnosed Neuroinflammatory DiseasesNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$2,936,094May 15, 2021April 30, 2026WILSON, MICHAEL Rreporter.nih.gov
UCSF Diabetic Foot Clinical Research UnitNIHNational Institute of Diabetes and Digestive and Kidney Diseases2022 to 2025$2,932,202September 15, 2018December 31, 2027CONTE, MICHAEL Sreporter.nih.gov
Regulation and function of mucosal IgA immune responses to mycobiota in the gut.NIHNational Institute of Allergy and Infectious Diseases2021 to 2025$2,924,410June 1, 2021May 31, 2027ILIEV, ILIYAN DIMITROVreporter.nih.gov
A Novel Immunologically Enhanced Probiotic for Treating Rheumatoid ArthritisNIHNational Institute of Allergy and Infectious Diseases2021 to 2023$2,922,693February 23, 2021January 31, 2025FANGER, GARYreporter.nih.gov
Complement in Pathogenesis and Experimental Therapy of ANCA DiseaseNIHNational Institute of Allergy and Infectious Diseases2021 to 2024$2,919,656July 1, 2020June 30, 2025SONG, WENCHAOreporter.nih.gov
Advancing an accessible, high-throughput and multiplex islet autoantibody test with self-collected capillary dried blood spots for regulatory clearanceNIHNational Institute of Diabetes and Digestive and Kidney Diseases2023 to 2025$2,919,236August 1, 2016May 31, 2026SEFTEL, DAVIDreporter.nih.gov
A Novel Probiotic for the Treatment of Sjogren's SyndromeNIHNational Institute of Dental & Craniofacial Research2021 to 2023$2,918,422May 12, 2021April 30, 2026FANGER, GARYreporter.nih.gov
Therapeutic targeting of protein interactions to reverse MLCK1-mediated intestinal barrier loss and ameliorate disease.NIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2025$2,917,818July 1, 2005June 30, 2029TURNER, JERROLD R.reporter.nih.gov
ABIN1 dysfunction in Lupus NephritisNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2025$2,909,013September 1, 2021June 30, 2027POWELL, DAVID W.reporter.nih.gov
iSTAR TregsNIHNational Institute of Diabetes and Digestive and Kidney Diseases2023 to 2025$2,906,574July 1, 2023June 30, 2027TANG, QIZHIreporter.nih.gov
Mechanisms of mucosal autoinflammation elucidated by a novel monogenic transcription factor defectNIHNational Institute of Allergy and Infectious Diseases2021 to 2025$2,902,111April 15, 2021March 31, 2026LUCAS, CARRIE L.reporter.nih.gov
Improving Self-Regulation and Social Support for Type 1 Diabetes During Emerging AdulthoodNIHNational Institute of Diabetes and Digestive and Kidney Diseases2022 to 2025$2,899,970May 1, 2022April 30, 2027BERG, CYNTHIA Areporter.nih.gov
Depleting autoantibodies for the treatment of autoimmunityNIHNational Institute of Allergy and Infectious Diseases2023 to 2025$2,898,618March 11, 2022February 28, 2027KANNANGANAT SIDHARTHAN, SUNILreporter.nih.gov
Role of CREM in Amebic Colitis and Inflammatory Bowel DiseaseNIHNational Institute of Allergy and Infectious Diseases2021 to 2025$2,896,698August 1, 1989December 31, 2027PETRI, WILLIAM Areporter.nih.gov
Dietary fat-activated colonocyte-macrophage ketone shuttle drives intestinal inflammationNIHNational Institute of Allergy and Infectious Diseases2025$2,893,480July 18, 2025June 30, 2029RUAN, HAI-BINreporter.nih.gov
Enhancement of autoimmunity in type 1 diabetes by glutenNIHNational Institute of Allergy and Infectious Diseases2021 to 2025$2,890,025September 17, 2021August 31, 2027CHERVONSKY, ALEXANDER Vreporter.nih.gov
The role of cytotoxic T cells in rheumatoid arthritis pathogenesisNIHNational Institute of Arthritis and Musculoskeletal and Skin Diseases2021 to 2025$2,877,343September 1, 2021August 31, 2026ANDRADE, FELIPEreporter.nih.gov
The Biogenesis of Platelet-Derived Extracellular Vesicles and their Impact on Megakaryocyte MaturationNIHNational Heart, Lung, and Blood Institute2021 to 2025$2,874,833April 20, 2021March 31, 2027MACHLUS, KELLIE RAEreporter.nih.gov
Stopping Hydroxychloroquine In Elderly Lupus Disease (SHIELD)NIHNational Institute of Arthritis and Musculoskeletal and Skin Diseases2023 to 2024$2,866,312August 17, 2023July 31, 2028IZMIRLY, PETERreporter.nih.gov
Translation of the UVA Advanced Automated Insulin Delivery Systems to Clinical Care in Young Children: Glycemic Control, Regulatory Acceptance and Optimization of Day to Day UseNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2022$2,865,164September 17, 2020June 30, 2024BRETON, MARC Dreporter.nih.gov
Characterize the Landscape and Origin of Hybrid Peptides in Beta CellsNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2025$2,864,714September 25, 2018June 30, 2027DELONG, THOMASreporter.nih.gov
Robust Mass Spectrometric Protein/Peptide Assays for Type 1 Diabetes Clinical ApplicationsNIHNational Institute of Diabetes and Digestive and Kidney Diseases2023 to 2025$2,862,122July 21, 2023June 30, 2027QIAN, WEI-JUNreporter.nih.gov
Vasculopathy and Systemic Sclerosis-Associated Interstitial Lung DiseaseNIHNational Heart, Lung, and Blood Institute2022 to 2025$2,859,896August 10, 2022July 31, 2027BERNSTEIN, ELANA J.reporter.nih.gov
TLR7 and TLR9-directed plasma cell formation: Dissecting the molecular basis for their differential dependence on IFN-induced signalsNIHNational Institute of Allergy and Infectious Diseases2021 to 2024$2,853,080July 10, 2020June 30, 2026LUND, FRANCES E.reporter.nih.gov
Genetic regulation of epithlial injury in ulcerative colitisNIHNational Institute of Diabetes and Digestive and Kidney Diseases2025$2,842,245September 22, 2025September 21, 2029KATTAH, MICHAEL GEORGEreporter.nih.gov
The role of senescent beta cells in T1D and T2DNIHNational Institute of Diabetes and Digestive and Kidney Diseases2022 to 2025$2,840,914September 19, 2022June 30, 2027KAESTNER, KLAUS Hreporter.nih.gov
Development of platforms for beta cell-specific delivery and ligand discoveryNIHNational Institute of Diabetes and Digestive and Kidney Diseases2023 to 2025$2,837,648July 1, 2023June 30, 2027CHOUDHARY, AMITreporter.nih.gov
Intestinal Inflammation: Signaling proteins and the rate of PMN transmigrationNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2025$2,831,952October 1, 2002April 30, 2027PARKOS, CHARLES Areporter.nih.gov
Role of mitochondria in SLE and its cardiovascular complicationsNIHNational Heart, Lung, and Blood Institute2021 to 2025$2,831,874August 25, 2021June 30, 2026LOOD, JAN CHRISTIANreporter.nih.gov
Absorption of vitamin B1 along the intestinal tract: Physiology, pathophysiology and cell biology aspectsNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2024$2,831,663August 1, 1999December 31, 2025SAID, HAMID Mreporter.nih.gov
Molecular Determinants of Usual Interstitial Pneumonia (UIP)NIHNational Heart, Lung, and Blood Institute2022 to 2025$2,826,957April 1, 2022March 31, 2027SCHWARTZ, DAVID ALBERTreporter.nih.gov
Polyamines and Hypusine in Type 1 Diabetes PathogenesisNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2025$2,825,507May 7, 2020July 31, 2030MIRMIRA, RAGHAVENDRA Greporter.nih.gov
Delivery of a Culturally Tailored Exercise Training Intervention for Hispanics with Multiple SclerosisNIHNational Institute on Minority Health and Health Disparities2025$2,825,047September 14, 2025June 30, 2029GEE, STEPHANIE SILVEIRAreporter.nih.gov
Impact of Loss-of-function NADPH Oxidase Variants on B cell Activation in SLENIHNational Institute of Arthritis and Musculoskeletal and Skin Diseases2021 to 2025$2,822,766February 1, 2021December 31, 2025JACKSON, SHAUN WILLIAMreporter.nih.gov
Genome editing of human pancreatic islets to withstand ischemic injuries and promote immune evasionNIHNational Institute of Diabetes and Digestive and Kidney Diseases2022 to 2025$2,817,305July 1, 2022April 30, 2027TANG, QIZHIreporter.nih.gov
Multimarker surface signatures of human islet derived extracellular vesiclesNIHNational Institute of Diabetes and Digestive and Kidney Diseases2022 to 2025$2,815,725September 22, 2022May 31, 2027ROUTENBERG, DAVID AARONreporter.nih.gov
Latent TGF-β2 Structure and ActivationNIHNational Heart, Lung, and Blood Institute2022 to 2025$2,811,726April 1, 2022March 31, 2026SPRINGER, TIMOTHY Areporter.nih.gov
Mechanism of microbiota-mediated potentiation of checkpoint blockade efficacy in lung cancerNIHNational Cancer Institute2021 to 2025$2,809,344August 1, 2021July 31, 2026LITTMAN, DANreporter.nih.gov
BCAP regulation of TLR7/9 signaling in LupusNIHNational Institute of Allergy and Infectious Diseases2021 to 2024$2,809,161December 1, 2019November 30, 2025HAMERMAN, JESSICA Areporter.nih.gov
Rheumatoid Arthritis and the Risk of Cardiovascular Disease: Biomarkers Risk Prediction and Underlying MechanismsNIHNational Heart, Lung, and Blood Institute2022 to 2025$2,807,438June 15, 2022May 31, 2027SOLOMON, DANIEL HALreporter.nih.gov
Toward a Validated in Vivo Imaging Marker of Axonal Damage Predictive of Progressive Disability in Multiple SclerosisNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$2,805,313April 1, 2021March 31, 2027HUANG, SUSIE YIreporter.nih.gov
Precise Infliximab Exposure and Pharmacodynamic Control to Achieve Deep Remission in Pediatric Crohn's DiseaseNIHNational Institute of Diabetes and Digestive and Kidney Diseases2022 to 2025$2,803,917June 1, 2022March 31, 2027MINAR, PHILLIP Preporter.nih.gov
WAVE Regulatory Complex in Primary Immunodeficiency Disease and autoimmunityNIHNational Institute of Allergy and Infectious Diseases2021 to 2025$2,801,318February 10, 2021January 31, 2026IRITANI, BRIAN Mreporter.nih.gov
Bacterial metabolites controlling Th17 and Treg cellsNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2024$2,799,466September 1, 2016July 31, 2025HUH, JUN R.reporter.nih.gov
Monitoring Disease in LupusNIHNational Institute of Arthritis and Musculoskeletal and Skin Diseases2021 to 2025$2,798,512March 8, 2019June 30, 2029MOHAN, CHANDRAreporter.nih.gov
Structure-Guided Design of Intestine-Selective AHR Agonists for Restoration of Gut Barrier Integrity in IBDNIHNational Institute of Diabetes and Digestive and Kidney Diseases2022 to 2025$2,795,439June 1, 2022March 31, 2027CHAIKOF, ELLIOTreporter.nih.gov
Comprehensive Proteomic Classifier for the Molecular Characterization of Pulmonary SarcoidosisNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,790,619August 15, 2021July 31, 2025BHARGAVA, MANEESHreporter.nih.gov
Whole Protein Arrays to Detect Antimicrobial Antibodies Associated with Triggering and Progression of Islet Autoimmunity in TEDDYNIHNational Institute of Diabetes and Digestive and Kidney Diseases2024 to 2025$2,788,474September 5, 2024August 31, 2027LABAER, JOSHUAreporter.nih.gov
Defining the influence of RA genetic susceptibility factors on T cell antigen specificity and functional stateNIHNational Institute of Arthritis and Musculoskeletal and Skin Diseases2021 to 2025$2,784,187August 2, 2013March 31, 2026RAYCHAUDHURI, SOUMYAreporter.nih.gov
Survival and potential of insulin-deficient beta cells in type 1 diabetesNIHNational Institute of Diabetes and Digestive and Kidney Diseases2022 to 2025$2,780,326September 20, 2022June 30, 2027SCHATZ, DESMOND ARTHURreporter.nih.gov
Vascularized Islet transplantation NICHE with local immunosuppression for the treatment of type 1 diabetesNIHNational Institute of Diabetes and Digestive and Kidney Diseases2022 to 2025$2,778,087July 1, 2022April 30, 2027GRATTONI, ALESSANDROreporter.nih.gov
Restoring Immune Balance in Hiddradenitis SuppurativaNIHNational Institute of Arthritis and Musculoskeletal and Skin Diseases2021 to 2024$2,776,428May 1, 2020April 30, 2026ROSENBLUM, MICHAEL DAVIDreporter.nih.gov
Biobehavioral Human-Machine Co-adaptation of the Artificial PancreasNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2024$2,773,326September 28, 2009March 31, 2026KOVATCHEV, BORIS Preporter.nih.gov
Treating colon cancer by regulating intestinal immunity through microbial metabolismNIHNational Cancer Institute2021 to 2025$2,772,249June 1, 2021May 31, 2027ARPAIA, NICHOLASreporter.nih.gov
Supramolecular biomaterials for tuning the inflammatory properties of the complement systemNIHNational Institute of Allergy and Infectious Diseases2022 to 2025$2,759,425June 1, 2022May 31, 2027COLLIER, JOEL Hreporter.nih.gov
Micro-nanotechnologies for the analysis of islet-derived extracellular vesicles implicated in Type 1 DiabetesNIHNational Institute of Diabetes and Digestive and Kidney Diseases2022 to 2025$2,758,753September 19, 2022June 30, 2027NG, ALPHONSUSreporter.nih.gov
Nuclear Receptor Control of T Cell Function in Discrete Intestinal MicroenvironmentsNIHNational Institute of Allergy and Infectious Diseases2022 to 2025$2,751,010September 23, 2021August 31, 2026SUNDRUD, MARK SCOTTreporter.nih.gov
Harnessing the anti-inflammatory activity of extracellular sialylation of IgG.NIHNational Institute of Allergy and Infectious Diseases2021 to 2025$2,749,084April 16, 2021March 31, 2026ANTHONY, ROBERT MCCULLOUGHreporter.nih.gov
Dupilumab in the Treatment of Pediatric Alopecia AreataNIHNational Institute of Allergy and Infectious Diseases2024 to 2025$2,738,616May 15, 2024April 30, 2029GUTTMAN, EMMAreporter.nih.gov
Wearable Metabolic Sensor for Monitoring of Lactate and Glucose for People with DiabetesNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2025$2,738,039September 1, 2021May 31, 2028TANGNEY, JARED RYLANreporter.nih.gov
Novel Targets for Reducing Atherosclerosis in Type 1 DiabetesNIHNational Heart, Lung, and Blood Institute2022 to 2025$2,734,575December 1, 2021November 30, 2026BIDDINGER, SUDHA Breporter.nih.gov
Nlrp3 inflammasome activation in early diabetic retinopathyNIHNational Eye Institute2021 to 2024$2,726,569September 1, 2020May 31, 2025AMBATI, JAYAKRISHNAreporter.nih.gov
Mechanisms of cannabidiol in persons with MS: the role of sleep and pain phenotypeNIHNational Center for Complementary & Integrative Health2021 to 2024$2,725,289August 15, 2021May 31, 2026BRALEY, TIFFANY JOYreporter.nih.gov
Identification and characterization of inflammatory bowel disease causal variantsNIHNational Institute of Diabetes and Digestive and Kidney Diseases2022 to 2025$2,724,317August 15, 2022June 30, 2027HUANG, HAILIANGreporter.nih.gov
Bridging clinical trial and real-world data via machine learning to advance rheumatoid arthritis treatment strategiesNIHNational Institute of Arthritis and Musculoskeletal and Skin Diseases2022 to 2025$2,718,736July 1, 2022June 30, 2027LIAO, KATHERINE PHOENIXreporter.nih.gov
Implications of Changes in Islet Exosomal Cargo in Type 1 DiabetesNIHNational Institute of Diabetes and Digestive and Kidney Diseases2022 to 2025$2,718,093September 19, 2022July 31, 2027SIMS, EMILY Kreporter.nih.gov
[18F]4FN PET Imaging of Innate Immunity Activation During Immunotherapy-Induced Adverse EventsNIHNational Cancer Institute2022 to 2025$2,714,023September 1, 2022August 31, 2027PIWNICA-WORMS, DAVIDreporter.nih.gov
Development of a B Cell TherapeuticNIHNational Institute of Allergy and Infectious Diseases2021 to 2024$2,713,112August 20, 2020July 31, 2025DITTEL, BONNIE Nreporter.nih.gov
Establishing Readiness of Dental Professionals in Practice-Based Research and Inter-Professional CareNIHNational Institute of Dental & Craniofacial Research2023 to 2025$2,709,841September 13, 2023June 30, 2028THYVALIKAKATH, THANKAM Preporter.nih.gov
Home-based actigraphy to predict disability progression and enhance clinical trials in multiple sclerosisNIHNational Institute of Nursing Research2021 to 2024$2,708,611September 7, 2020June 30, 2026MOWRY, ELLEN M.reporter.nih.gov
Adaptive epigenetic mechanisms of beta and immune cells in autoimmune diabetesNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2024$2,708,550July 15, 2021June 30, 2025HEROLD, KEVAN Creporter.nih.gov
ADAPTIVE MOTIF-BASED CONTROL (AMBC): A FUNDAMENTALLY NEW APPROACH TO AUTOMATED TREATMENT OPTIMIZATION FOR TYPE 1 DIABETESNIHNational Institute of Diabetes and Digestive and Kidney Diseases2022 to 2025$2,707,952August 17, 2022May 31, 2027KOVATCHEV, BORIS Preporter.nih.gov
Dietary Regulation of Intestinal Inflammation and RepairNIHNational Institute of Diabetes and Digestive and Kidney Diseases2022 to 2025$2,700,479March 15, 2022January 31, 2027ARTIS, DAVIDreporter.nih.gov
Neurodegeneration Underlying Distinct Disabilities in Multiple Sclerosis Using a Cell-Specific, Region-Specific, and Sex-Specific ApproachNIHNational Institute of Neurological Disorders and Stroke2023 to 2025$2,697,814May 15, 2023April 30, 2031VOSKUHL, RHONDA Rreporter.nih.gov
Therapeutic Targeting of the Myofibroblast in Fibrotic Lung DiseaseNIHNational Heart, Lung, and Blood Institute2021 to 2022$2,694,152September 16, 2013July 31, 2025THANNICKAL, VICTOR J.reporter.nih.gov
Pathobiology of ANCA Glomerulonephritis: Targeting Adaptive and Innate Immune Processes for Precision TherapiesNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2024$2,693,358July 1, 2020May 31, 2025FALK, RONALD Jreporter.nih.gov
Immunology of advancing disease among minorities with Multiple SclerosisNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$2,692,372July 1, 2021May 31, 2027MONSON, NANCY Lreporter.nih.gov
Regulation of neutrophil plasticity, heterogenicity, and functional ambivalency by WNT5 in colitisNIHNational Institute of Allergy and Infectious Diseases2025$2,685,326July 7, 2025June 30, 2029WU, DIANQINGreporter.nih.gov
A Phase II Controlled Trial of Allogeneic Mesenchymal Stromal Cells for the Treatment of Refractory Lupus (MiSLE)NIHNational Institute of Allergy and Infectious Diseases2024 to 2025$2,684,733August 1, 2024May 31, 2027GILKESON, GARY Sreporter.nih.gov
B-lymphocyte Targeting Therapies for Autoimmune DiabetesNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2025$2,678,494April 1, 2013March 31, 2026SERREZE, DAVID Vreporter.nih.gov
Spermidine as a New Therapy for Colitis and Chemopreventive for Colitis-associated CarcinogenesisNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2024$2,674,708March 31, 2021February 28, 2026WILSON, KEITH T.reporter.nih.gov
Mechanisms of sphingolipid signaling in vascular health and diseaseNIHNational Heart, Lung, and Blood Institute2021 to 2023$2,673,681January 18, 2017December 31, 2023HLA, TIMOTHY TUNreporter.nih.gov
Elucidating IgA nephropathy through Genetic Studies of IgA1 GlycosylationNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2024$2,665,061May 1, 2009April 30, 2026GHARAVI, ALI Greporter.nih.gov
Unraveling the molecular mechanisms of impaired central tolerance in COPA syndromeNIHNational Institute of Allergy and Infectious Diseases2022 to 2025$2,664,560March 1, 2022February 28, 2027SHUM, ANTHONYreporter.nih.gov
Macrophage Heterogeneity in Rheumatoid ArthritisNIHNational Institute of Arthritis and Musculoskeletal and Skin Diseases2022 to 2025$2,660,867April 15, 2022February 28, 2027WINTER, DEBORAH RACHELLEreporter.nih.gov
SGLT2 Inhibitors, Ketogenesis, and KetoacidosisNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2025$2,658,806June 1, 1998June 30, 2027DEFRONZO, RALPH Areporter.nih.gov
Autoimmune Stem-like CD8 T cells in Type 1 DiabetesNIHNational Institute of Allergy and Infectious Diseases2023 to 2025$2,657,421June 8, 2023May 31, 2028SCHIETINGER, ANDREAreporter.nih.gov
Administrative Supplement to Investigate the Effects of Long COVID on SELA study participantsNIHNational Institute on Minority Health and Health Disparities2021 to 2024$2,657,323July 28, 2021April 30, 2026RAMOS, PAULA SOFIAreporter.nih.gov
The Role of Crypt Fissioning in IBD Ulcer HealingNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2024$2,649,727February 24, 2021January 31, 2026BARRETT, TERRENCE A.reporter.nih.gov
Neurosarcoidosis: Clinical Phenotype, Biomarkers and ImmunopathogensisNIHNational Institute of Neurological Disorders and Stroke2022 to 2025$2,640,352September 1, 2022August 31, 2027PARDO-VILLAMIZAR, CARLOS Areporter.nih.gov
Type 1 diabetes genetic risk scores for the diagnosis of diabetes type in children of diverse racial and ethnic backgroundNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2024$2,640,074February 15, 2021January 31, 2026REDONDO, MARIA JOSEreporter.nih.gov
Lymphatic regulation of lymph node function in lupusNIHNational Institute of Allergy and Infectious Diseases2021 to 2025$2,639,789February 1, 2010January 31, 2028LU, THERESA T.reporter.nih.gov
Gut bacterial metallophores in the development and severity of inflammatory bowel diseaseNIHNational Institute of Diabetes and Digestive and Kidney Diseases2022 to 2025$2,638,713April 1, 2022February 28, 2027SAMUELSON, DERRICK Rreporter.nih.gov
Natural History of Pre-Diabetic Autoimmunity (DAISY)NIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2024$2,635,445November 1, 1994April 30, 2026REWERS, MARIAN Jreporter.nih.gov
Alterations of leukocyte integrin signaling leading to diabetes and autoimmunityNIHNational Institute of Allergy and Infectious Diseases2022 to 2025$2,634,144August 12, 2022July 31, 2026ANDERSON, MARK Sreporter.nih.gov
Role of GRAIL in B cell tolerance and B-cell mediated inflammationNIHNational Institute of Allergy and Infectious Diseases2025$2,630,572August 1, 2025July 31, 2029NURIEVA, ROZA INSAFETDINOVNAreporter.nih.gov
Modulating pathogenic T cells in Type 1 diabetesNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2025$2,630,520April 1, 2000May 31, 2029HEROLD, KEVAN Creporter.nih.gov
Role of epithelial ROS signaling in mediating psychological stress-induced mucosal dysfunction and colitis predispositionNIHNational Institute of Diabetes and Digestive and Kidney Diseases2022 to 2025$2,622,833July 31, 2022May 31, 2027ALLEN, JACOB MATTHEWreporter.nih.gov
Role of neutrophils and eosinophils in bacterial ligand-induced vasculitisNIHNational Institute of Allergy and Infectious Diseases2021 to 2024$2,620,275September 23, 2020August 31, 2025ARDITI, MOSHEreporter.nih.gov
Mechanisms of telomere-induced disease: Role of intestinal malabsorption, barrier dysfunction and dsybiosis.NIHNational Institute of Diabetes and Digestive and Kidney Diseases2022 to 2025$2,617,623June 1, 2022March 31, 2027SAHIN, ERGUNreporter.nih.gov
Role of the environmental sensor, AhR on colitisNIHNational Institute of Allergy and Infectious Diseases2021 to 2025$2,615,887September 27, 2021August 31, 2027NAGARKATTI, PRAKASH Sreporter.nih.gov
ACT1VATE: Addressing Emotional Distress to Improve Outcomes among Diverse Adults with Type 1 DiabetesNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2025$2,615,237September 15, 2020August 31, 2027FORTMANN, ADELAIDE Lreporter.nih.gov
The Impact of Diabetes on Patients with Glomerular Disease: CureGN-DiabetesNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2025$2,613,461March 11, 2021January 31, 2027MOTTL, AMYreporter.nih.gov
Development of Immune ToleranceNIHNational Institute of Allergy and Infectious Diseases2021 to 2025$2,613,354March 15, 2016February 28, 2027FARRAR, MICHAEL ARCHIBALDreporter.nih.gov
Pandemrix and T Cell Immunology in NarcolepsyNIHNational Institute of Allergy and Infectious Diseases2021 to 2024$2,607,677May 13, 2021April 30, 2025MIGNOT, EMMANUEL Jreporter.nih.gov
Pathogenesis of Primary Biliary CholangitisNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2024$2,607,525December 21, 2020November 30, 2025LAZARIDIS, KONSTANTINOS Nreporter.nih.gov
Autoantibodies define scleroderma subgroups with distinct relationships to cancerNIHNational Institute of Arthritis and Musculoskeletal and Skin Diseases2021 to 2025$2,606,356April 9, 2018July 31, 2029SHAH, AMI AALOKreporter.nih.gov
Novel compounds for the treatment of systemic sclerosis-associated interstitial lung diseaseNIHNational Heart, Lung, and Blood Institute2024 to 2025$2,600,290July 15, 2024June 30, 2027SCARNEO, SCOTTreporter.nih.gov
Neutrophil plasticity in autoimmune diseaseNIHNational Institute of Allergy and Infectious Diseases2021 to 2024$2,593,636February 10, 2020January 31, 2026MAYADAS, TANYA Nreporter.nih.gov
Determining genomic and host-environment contributions to IBD phenotypesNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2025$2,592,024September 30, 2022June 30, 2027MCGOVERN, DERMOT PATRICKreporter.nih.gov
Determinants of induced Treg and inflammatory Th17 cell balance in response to potentially pathogenic microbiotaNIHNational Institute of Allergy and Infectious Diseases2021 to 2025$2,589,752March 15, 2021July 6, 2026LITTMAN, DANreporter.nih.gov
Intestinal surveillance by intraepithelial lymphocytesNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2025$2,589,419July 1, 2017April 30, 2026MUCIDA, DANIEL Sreporter.nih.gov
Generating spatial and functional maps of cell-to-cell interactions in MS lesionsNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$2,587,248March 15, 2021February 28, 2026PITT, DAVIDreporter.nih.gov
Teamwork, Targets, Technology, and Tight Control in Newly Diagnosed Pediatric T1D: 4T StudyNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2024$2,578,394February 7, 2020January 31, 2026MAAHS, DAVID MATTHEWreporter.nih.gov
Micro-TeACH (Microbiome Technology and Analytic Center Hub)NIHNational Institute of Arthritis and Musculoskeletal and Skin Diseases2022 to 2025$2,568,320March 10, 2022December 31, 2026SCHER, JOSE U.reporter.nih.gov
Dietary fiber and soy protein-based microbiome metabolites for IBD preventionNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2025$2,557,667July 3, 2018December 31, 2026MARTENS, ERIC Creporter.nih.gov
Regulatory and Mechanistic Understanding of ADAR-Mediated RNA EditingNIHNational Institute of General Medical Sciences2022 to 2025$2,555,687June 1, 2022April 30, 2027LI, JIN BILLYreporter.nih.gov
Engineering IgG-specific endoglycosidases to selectively defeat effector functionsNIHNational Institute of Allergy and Infectious Diseases2021 to 2025$2,552,024April 8, 2020April 30, 2030SUNDBERG, ERIC JOHNreporter.nih.gov
Three-dimensional conformation changes associated with T cell memory and autoimmunityNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2024$2,550,277September 15, 2020June 30, 2025HAWKINS, RAYMOND DAVIDreporter.nih.gov
Quantifying proteins in plasma do democratize personalized medicine for patients with type 1 diabetesNIHNational Institute of Diabetes and Digestive and Kidney Diseases2023 to 2025$2,545,042July 21, 2023June 30, 2027HOOFNAGLE, ANDREW Nreporter.nih.gov
Functional consequences of intergenic autoimmune disease risk variantsNIHNational Institute of Allergy and Infectious Diseases2023 to 2025$2,539,964March 3, 2023February 29, 2028NIEWOLD, TIMOTHY Breporter.nih.gov
Co-registration of Cell Organization, Phenotype and Function in the Human Pancreas During Type 1 DiabetesNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2025$2,539,894September 17, 2021June 30, 2027ATKINSON, MARK A.reporter.nih.gov
UroEDIC Bladder: Bladder Dysfunction in Type 1 DiabetesNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2024$2,536,849June 1, 2021March 31, 2026SARMA, ARUNA Vreporter.nih.gov
Clonal expansion: a marker of disease activity in stage 1 T1DNIHNational Institute of Diabetes and Digestive and Kidney Diseases2024 to 2025$2,532,731July 15, 2024June 30, 2027LONG, S ALICEreporter.nih.gov
RNA binding proteins in end-organ autoimmune pathologyNIHNational Institute of Allergy and Infectious Diseases2022 to 2025$2,532,453February 8, 2022January 31, 2027GAFFEN, SARAH Lreporter.nih.gov
Expanded Double Negative T cells in SLE.NIHNational Institute of Allergy and Infectious Diseases2021 to 2025$2,529,548May 1, 2010May 31, 2026TSOKOS, GEORGE Creporter.nih.gov
Remedy to Diabetes Distress (R2D2): A Scalable Screen to Treat Program for School-Age FamiliesNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2024$2,528,309September 5, 2020August 31, 2025PATTON, SUSANA Rreporter.nih.gov
Role of ZBP1 in pathogenesis of Salmonella biofilmsNIHNational Institute of Allergy and Infectious Diseases2023 to 2025$2,527,208May 11, 2023April 30, 2028BALACHANDRAN, SIDDHARTHreporter.nih.gov
Sustained Delivery of Tizanidine for Maintenance Treatment of Moderate to Severe SpasticityNIHNational Institute of Neurological Disorders and Stroke2021 to 2022$2,527,179April 15, 2019August 31, 2025WATKINS, GREGORYreporter.nih.gov
Modeling, pathogenesis and treatment of idiopathic pulmonary fibrosisNIHNational Heart, Lung, and Blood Institute2021 to 2022$2,527,128September 20, 2016May 31, 2025SNOECK, HANS-WILLEM Ereporter.nih.gov
Immunologic Mechanisms and Rheumatic DiseasesNIHNational Institute of Arthritis and Musculoskeletal and Skin Diseases2021 to 2025$2,525,449July 1, 1985July 31, 2030GRAVALLESE, ELLEN Mreporter.nih.gov
Neuronal and molecular mechanisms underlying neural regulation of innate immunityNIHNational Institute of General Medical Sciences2021 to 2025$2,524,273September 12, 2017August 31, 2027SUN, JINGRUreporter.nih.gov
Neuro-immune regulation of intestinal inflammationNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2024$2,522,331September 17, 2020July 31, 2025ARTIS, DAVIDreporter.nih.gov
Host's and microbiota's contribution to sexual dimorphism of autoimmunityNIHNational Institute of Allergy and Infectious Diseases2021 to 2025$2,515,770August 16, 2017November 30, 2027CHERVONSKY, ALEXANDER Vreporter.nih.gov
Targeting the Mycobiome in Genetically Defined Patients with Crohns DiseaseNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2025$2,513,409May 1, 2021February 28, 2026UNDERHILL, DAVID M.reporter.nih.gov
Dosing and Pilot Efficacy of 2'-Fucosyllactose in Inflammatory Bowel DiseaseNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2021 to 2025$2,512,710July 12, 2018June 30, 2027DENSON, LEE ARMISTEADreporter.nih.gov
Finding the optimal balance of immunotherapy efficacy and toxicity.NIHNational Institute of Allergy and Infectious Diseases2021 to 2024$2,511,216June 12, 2020May 31, 2025GERBER, DAVID ERICreporter.nih.gov
Mechanisms of Gastrointestinal COVID-19NIHNational Institute of Allergy and Infectious Diseases2022 to 2025$2,503,469July 15, 2022June 30, 2027CIORBA, MATTHEW AARONreporter.nih.gov
Regulation and Function of Nuclear cGASNIHNational Institute of Allergy and Infectious Diseases2021 to 2024$2,498,128September 22, 2020August 31, 2025STETSON, DANIEL Breporter.nih.gov
Continuation Application for the development of Integrated continuous and single-use (ICS) bioproduction platform (Phase IIB)NIHNational Institute of General Medical Sciences2022 to 2023$2,495,306January 1, 2016March 31, 2024SHINKAZH, OLEGreporter.nih.gov
Regulatory Variants in Human Skin DiseasesNIHNational Institute of Arthritis and Musculoskeletal and Skin Diseases2021 to 2025$2,487,678May 1, 2020May 31, 2030KHAVARI, PAULreporter.nih.gov
KIR and HLA effects in CNS paraneoplastic syndromes and related neuroimmune conditionsNIHNational Institute of Neurological Disorders and Stroke2022 to 2025$2,481,052September 30, 2020May 31, 2026MIGNOT, EMMANUEL Jreporter.nih.gov
Molecular Basis of Pathogenicity of IgA1-containing Immune ComplexesNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2025$2,480,984June 1, 2007March 31, 2028NOVAK, JANreporter.nih.gov
Bidirectional Brain-Gut interactions, chronic neuroinflammation and neurodegeneration after traumatic brain injuryNIHNational Institute of Neurological Disorders and Stroke2022 to 2025$2,480,051August 15, 2022July 31, 2027FADEN, ALAN IRAreporter.nih.gov
Imaging Neurodegeneration in Multiple SclerosisNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$2,478,045April 1, 2013June 30, 2029SAIDHA, SHIVreporter.nih.gov
Ketone Monitoring Approaches for DKA Risk Mitigation in People with T1D on Adjunctive SGLT2 Inhibitors (KARMA)NIHNational Institute of Diabetes and Digestive and Kidney Diseases2025$2,477,577September 11, 2025August 31, 2028PRATLEY, RICHARD Ereporter.nih.gov
The role of TLRs, Type II IFN and Type III IFN in a Murine Model of AutoinflammationNIHNational Institute of Allergy and Infectious Diseases2021 to 2025$2,474,645March 19, 2021February 28, 2026MARSHAK-ROTHSTEIN, ANNreporter.nih.gov
New way in delivering immunomodulatory drugs in T1DNIHNational Institute of Allergy and Infectious Diseases2022 to 2025$2,465,695February 17, 2022January 31, 2026ABDI, REZAreporter.nih.gov
PET Sphingosine-1-Phosphate Receptor 1 (S1P1) radiotracer for inflammation response in multiple sclerosisNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$2,465,277September 30, 2017May 31, 2028TU, ZHUDEreporter.nih.gov
High-resolution, virome-wide infection analysis in type 1 diabetes birth cohortsNIHNational Institute of Diabetes and Digestive and Kidney Diseases2024 to 2025$2,459,418June 1, 2024May 31, 2027ALTIN, JOHNreporter.nih.gov
IL-2R-dependent mechanisms in regulation of Treg homeostasis and autoimmunityNIHNational Institute of Allergy and Infectious Diseases2021 to 2025$2,459,074December 10, 2019November 30, 2025MALEK, THOMAS Rreporter.nih.gov
Structure, function, and modulation of claudin cation channels in the GI tractNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2025$2,456,433September 30, 2021July 31, 2027WEBER, CHRISTOPHERreporter.nih.gov
Tolerance-programming biomaterial-based Intranasal ASIT for the treatment of autoimmunityNIHNational Institute of Allergy and Infectious Diseases2021 to 2025$2,456,250September 15, 2021August 31, 2026WILSON, DAVID SCOTTreporter.nih.gov
Defining how TCR strength of signal modulates Treg functionNIHNational Institute of Allergy and Infectious Diseases2022 to 2025$2,454,919September 19, 2022July 31, 2027EVAVOLD, BRIAN Dreporter.nih.gov
Pathogenesis of Lupus NephritisNIHNational Institute of Allergy and Infectious Diseases2021 to 2024$2,451,240May 6, 2020April 30, 2025CRAFT, JOSEPH EDGARreporter.nih.gov
SYK and ZAP70 kinases in lymphocyte selectionNIHNational Institute of Allergy and Infectious Diseases2022 to 2025$2,450,839February 1, 2022January 31, 2027MÜSCHEN, MARKUSreporter.nih.gov
Type 1 Diabetes Impacts of Semaglutide on Cardiovascular Outcomes (T1-DISCO)NIHNational Heart, Lung, and Blood Institute2022 to 2025$2,447,499July 27, 2022June 30, 2027NADEAU, KRISTEN JANEreporter.nih.gov
How do CNS fibroblasts regulate the response to neuroinflammation?NIHNational Institute of Neurological Disorders and Stroke2021 to 2025$2,446,884January 1, 2021December 31, 2025DANEMAN, RICHARDreporter.nih.gov
Ca2+ and secretory dynamics in salivary acinar cellsNIHNational Institute of Dental & Craniofacial Research2021 to 2025$2,446,451August 15, 2002June 30, 2028YULE, DAVID Ireporter.nih.gov
A Toolkit for Analysis and Visualization of Preclinical Rodent Neuroimaging ExperimentsNIHNational Institute of Neurological Disorders and Stroke2022 to 2025$2,445,717April 1, 2022March 31, 2027SHATTUCK, DAVID Wreporter.nih.gov
Mechanisms regulating VEGF receptors in diabetic angiogenesisNIHNational Heart, Lung, and Blood Institute2021 to 2023$2,443,536January 1, 2016June 30, 2025CHEN, HONGreporter.nih.gov
Intracellular nucleic acid detection in autoimmunityNIHNational Institute of Allergy and Infectious Diseases2021 to 2024$2,440,748May 15, 2010April 30, 2025STETSON, DANIEL Breporter.nih.gov
Humanized Mouse Avatars for T1DNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2023$2,439,759September 25, 2014May 31, 2024GREINER, DALE LESLIEreporter.nih.gov
A Novel Immunological-Directed Biotherapy for Treating Rheumatoid ArthritisNIHNational Institute on Aging2023 to 2025$2,434,680September 4, 2023June 30, 2027FANGER, GARYreporter.nih.gov
Non-Standard Protein Design in Molecular Endocrinology: Insulin and GlucagonNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2024$2,434,606August 1, 1989June 30, 2025WEISS, MICHAEL AARONreporter.nih.gov
Mechanisms by which effector T cells modulate endogenous remyelinationNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$2,434,021July 1, 2000November 30, 2026CALABRESI, PETER Areporter.nih.gov
Characterization of T cells in MOG antibody-associated diseaseNIHNational Institute of Allergy and Infectious Diseases2023 to 2025$2,432,350July 1, 2023June 30, 2028ZAMVIL, SCOTT Sreporter.nih.gov
Accelerating Delivery of rheumatic heart disease preventive iNterventions in Uganda (ADUNU)NIHNational Heart, Lung, and Blood Institute2022 to 2025$2,430,276September 1, 2022July 31, 2027BEATON, ANDREA ZAWACKIreporter.nih.gov
Engineering islet-like organoids from gastric stem cells for T1D cell replacement therapyNIHNational Institute of Diabetes and Digestive and Kidney Diseases2022 to 2025$2,428,878September 12, 2022May 31, 2026RAFII, SHAHINreporter.nih.gov
Pooled analysis of multiple sclerosis findings on multi-site 7 Tesla MRINIHNational Institute of Neurological Disorders and Stroke2021 to 2025$2,425,431July 1, 2021June 30, 2027HARRISON, DANIEL Mreporter.nih.gov
Lacritin Regulation of Homeostasis and Ocular Surface HealthNIHNational Eye Institute2021 to 2025$2,424,560September 1, 2021July 31, 2026LAURIE, GORDON WILLIAMreporter.nih.gov
Photoresponsive materials to study matricellular signaling dynamics during crypt formation and fissionNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2025$2,423,541August 1, 2019April 30, 2028ANSETH, KRISTI S.reporter.nih.gov
Protein Sialylation and De-Sialyation in Cell Surface Glycoprotein Homeostasis and DiseaseNIHNational Institute of Allergy and Infectious Diseases2021 to 2025$2,422,875February 1, 2021January 31, 2026MARTH, JAMEYreporter.nih.gov
Role of dietary fiber-microbiota Interactions in the development and function of small intestinal T cellsNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2025$2,421,990September 1, 2021July 31, 2026CERVANTES BARRAGAN, LUISAreporter.nih.gov
Immunomodulatory Therapy for Neuropathic PainNIHNational Institute of Neurological Disorders and Stroke2021 to 2023$2,420,195September 1, 2018August 31, 2025CHEN, RIDONGreporter.nih.gov
Integrative analysis of high dimensional tissue molecular data to define key biological systems in autoimmune diseases (SBC)NIHNational Institute of Arthritis and Musculoskeletal and Skin Diseases2022 to 2025$2,419,724March 18, 2022December 31, 2026RAYCHAUDHURI, SOUMYAreporter.nih.gov
Glycosyltransferase Function in Development and DiseaseNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2025$2,418,000September 15, 1994March 31, 2027MARTH, JAMEYreporter.nih.gov
Artificial Pancreas - Adolescent Physiology and Psychology Longitudinal Evaluation (A.P. APPLE)NIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2024$2,415,579April 1, 2020March 31, 2026DEBOER, MARK DANIELreporter.nih.gov
Virome and Immune Responses associated with IA and Type 1 DiabetesNIHNational Institute of Diabetes and Digestive and Kidney Diseases2024 to 2025$2,412,388March 5, 2024January 31, 2027LLOYD, RICHARD Ereporter.nih.gov
Genetic Linkage in LupusNIHNational Institute of Allergy and Infectious Diseases2021 to 2025$2,409,142July 1, 1987May 31, 2027KOTTYAN, LEAH CLAIREreporter.nih.gov
Tuft cell heterogeneity in function, lineage, and structure in ileal inflammatory diseaseNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2024$2,405,842February 15, 2016January 31, 2026LAU, KEN Sreporter.nih.gov
Continuation of The Collaborative Islet Transplantation Registry (CITR)NIHNational Institute of Diabetes and Digestive and Kidney Diseases2022 to 2025$2,399,074September 15, 2022June 30, 2027PAYNE, ELIZABETH HOLLYreporter.nih.gov
Leveraging early-life microbes to prevent type 1 diabetesNIHNational Institute of Diabetes and Digestive and Kidney Diseases2023 to 2025$2,398,489April 1, 2023February 29, 2028SILVERMAN, MICHAEL Areporter.nih.gov
Molecular Pathways Regulating Tissue-resident Memory T cells in the GutNIHNational Institute of Allergy and Infectious Diseases2022 to 2025$2,397,988March 1, 2022February 28, 2027DOUGAN, MICHAEL LAWRENCEreporter.nih.gov
Role of alveolar macrophage in omega-3 fatty acid amelioration of silica-triggered autoimmunity.NIHNational Institute of Environmental Health Sciences2021 to 2025$2,397,078June 1, 2017October 31, 2027PESTKA, JAMES Jreporter.nih.gov
Pathogenesis of kidney disease in type 1 diabetes: a modern kidney biopsy cohortNIHNational Institute of Diabetes and Digestive and Kidney Diseases2022 to 2025$2,395,247May 23, 2022March 31, 2027DE BOER, IAN Hreporter.nih.gov
Neural control of pancreatic endocrine function in obesity and diabetesNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2024$2,392,222January 6, 2021December 31, 2025STANLEY, SARAH AMYreporter.nih.gov
Scalable and transplantable pancreatic islet organoids with engineered oxygenationNIHNational Institute of Diabetes and Digestive and Kidney Diseases2025$2,390,830September 1, 2025August 31, 2029KOMATSU, HIROTAKEreporter.nih.gov
A mechanism to minimize auto-reactivity in the tissue-resident memory T cell poolNIHNational Institute of Allergy and Infectious Diseases2021 to 2025$2,390,315June 1, 2021May 31, 2026MEMPEL, THORSTEN ROMANreporter.nih.gov
Lung fibrosis modeling and compound testing platform using fibrotic lung ECM that recreates the fibrotic disease environment to improve predictiveness and accelerate anti-fibrotic drug developmentNIHNational Heart, Lung, and Blood Institute2021 to 2023$2,389,178September 1, 2021February 28, 2024O'NEILL, JOHN DAVIDreporter.nih.gov
Molecular Characterization of Progressive Pulmonary SarcoidosisNIHNational Heart, Lung, and Blood Institute2023 to 2025$2,384,181September 1, 2023July 31, 2027MAIER, LISA Areporter.nih.gov
Decode Mitochondrial Morphology Dynamics to Predict Cell Fate DecisionsNIHNational Institute of General Medical Sciences2022 to 2025$2,379,500September 8, 2022August 31, 2027SCHOENEBERG, JOHANNESreporter.nih.gov
Unraveling strain-level variation in the induction of anti-inflammatory responses in the intestineNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2025$2,378,553January 1, 2021December 31, 2026AHERN, PHILIP PATRICKreporter.nih.gov
Ontogenetic niche of B cells at the CNS borders in homeostasis, aging and autoimmunityNIHNational Institute of Allergy and Infectious Diseases2022 to 2025$2,372,392February 1, 2022January 31, 2027COLONNA, MARCOreporter.nih.gov
Strengths-Based Multi-Level Behavioral Intervention to Promote Resilience and Self-Management in Youth with Type 1 DiabetesNIHNational Institute of Diabetes and Digestive and Kidney Diseases2022 to 2025$2,369,928July 20, 2022May 31, 2028HILLIARD, MARISA ELLENreporter.nih.gov
Post-Initiation control of transcription in inflammatory macrophagesNIHNational Institute of Allergy and Infectious Diseases2021 to 2024$2,363,024December 23, 2019November 30, 2025ROGATSKY, INEZreporter.nih.gov
Control of Neutrophilic Inflammation in Intestinal Health and DiseaseNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2024$2,362,552September 1, 2016July 31, 2025MCCORMICK, BETH Areporter.nih.gov
Regulation of pancreatic islet cell fateNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2025$2,361,366August 1, 2009July 31, 2027SUSSEL, LORIreporter.nih.gov
Immunologic and Imaging studies with TNF Therapy in Prodromal SynucleinopathiesNIHNational Institute on Aging2025$2,361,361September 1, 2025August 31, 2030CEDARBAUM, JESSEreporter.nih.gov
Effect of Dietary Carbohydrate on Diabetes Control and Beta Cell Function in Children with Newly Diagnosed Diabetes.”NIHNational Institute of Diabetes and Digestive and Kidney Diseases2023 to 2025$2,359,048May 1, 2023April 30, 2029LENNERZ, BELINDA Sreporter.nih.gov
Statistical Methods for Multilevel Multivariate Functional StudiesNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$2,357,762January 1, 2009June 30, 2027CRAINICEANU, CIPRIAN Mreporter.nih.gov
Metabolic Landscape of the Aging LungNIHNational Heart, Lung, and Blood Institute2021 to 2023$2,355,987May 15, 2020April 30, 2026BARNES, JARROD W.reporter.nih.gov
Mount Sinai NYC Genetics Research Center: Multi-omic integration across data-types, cell niches and populationsNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2025$2,355,463September 30, 2002June 30, 2027CHO, JUDY H.reporter.nih.gov
Targeting bacterial proteases involved in PAR signaling to treat inflammatory bowel diseasesNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2025$2,355,154September 21, 2021July 31, 2026BOGYO, MATTHEWreporter.nih.gov
Neuronal antigen surveillance and autoimmunity in CNS demyelinating diseaseNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$2,354,214July 15, 2020April 30, 2025HOWE, CHARLES LEEreporter.nih.gov
Lymphatic ERG signaling in scleroderma fibrosisNIHNational Institute of Arthritis and Musculoskeletal and Skin Diseases2022 to 2025$2,352,935July 7, 2022May 31, 2027TROJANOWSKA, MARIAreporter.nih.gov
Mitigating Diabetic Ketoacidosis in People with T1D and Chronic Kidney Disease on an SGLT1&2 Inhibitor: Ketosis Risk Factor Determination and Incorporation into an Enhanced Glucose Ketone ReportNIHNational Institute of Diabetes and Digestive and Kidney Diseases2025$2,352,906September 1, 2025August 31, 2028BERGENSTAL, RICHARD MAURITZreporter.nih.gov
Intermittent fasting restores salivary gland function in Sjögren’s syndromeNIHNational Institute of Dental & Craniofacial Research2021 to 2025$2,348,947March 3, 2021February 28, 2027ZHOU, JINGreporter.nih.gov
Protein-polymer nanomedicine for Sjogren's SyndromeNIHNational Eye Institute2021 to 2025$2,348,434March 1, 2017May 31, 2025HAMM-ALVAREZ, SARAH Freporter.nih.gov
Muscle building supplement HMB for remyelinationNIHNational Center for Complementary & Integrative Health2021 to 2024$2,347,150July 1, 2020June 30, 2025PAHAN, KALIPADAreporter.nih.gov
Thinking Outside the Clinic: A Digital Health Approach for Young Adults with Type 1 DiabetesNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2024$2,345,203April 1, 2020March 31, 2026CATHERINE STANGER, CATHERINE STANGER CATHERINE STANGERreporter.nih.gov
Care partner-assisted ImplementatiOn of Patch HybrId Closed Loop Insulin Delivery for Older Adults with T1D (COPILOT)NIHNational Institute of Diabetes and Digestive and Kidney Diseases2025$2,345,176September 3, 2025August 31, 2028HENDERSON, ROBERT Jreporter.nih.gov
Origin and Function of Double Negative T cells in LupusNIHNational Institute of Allergy and Infectious Diseases2021 to 2025$2,344,269November 19, 2020October 31, 2025RANDALL, TROY Dreporter.nih.gov
Islet-specific CD8 T cells in the pathogenesis of type 1 diabetesNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2025$2,344,031August 20, 2013May 31, 2030NAKAYAMA, MAKIreporter.nih.gov
Autoimmune Regulator gene (Aire)-mediated tolerance to pregnancy-associated self-antigensNIHNational Institute of Allergy and Infectious Diseases2021 to 2023$2,342,665August 21, 2019July 31, 2025MACKENZIE, TIPPIreporter.nih.gov
Determining the mechanism of IFIH1 disease-associated variants on beta-cell and immune responses in Type 1 diabetesNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2022$2,332,346September 15, 2020December 31, 2022TSE, HUBERT Mreporter.nih.gov
Modeling autoimmune pathogenesis and beta cell destruction by T1D immune systemsNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2023$2,328,420September 20, 2019May 31, 2024SYKES, MEGANreporter.nih.gov
Sleep optimization to improve glycemic control in adults with type 1 diabetesNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2024$2,328,270July 1, 2020April 30, 2026MARTYN-NEMETH, PAMELA ANNreporter.nih.gov
Impact of symbiotic protists on intestinal T cell homeostasis and inflammation.NIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2025$2,328,152March 1, 2021February 28, 2026HOWITT, MICHAEL Rreporter.nih.gov
Sex and gender differences in lupus - intersection between immunometabolism, epigenetic remodeling and cardiac involvementNIHNational Institute of Allergy and Infectious Diseases2021 to 2024$2,327,472August 16, 2021July 31, 2025JEFFERIES, CAROLINEreporter.nih.gov
The KQ1 serum study: soluble biomarkers for T1D risk, development & progressionNIHNational Institute of Diabetes and Digestive and Kidney Diseases2024 to 2025$2,326,300February 1, 2024January 31, 2026HOMANN, DIRKreporter.nih.gov
Identifying lifelong factors that impact brain health and outcomes in type 1 diabetes: The Cognition and Longitudinal Assessments of Risk Factors over 30 Years (CLARiFY) Diabetes Complications StudyNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2025$2,325,031September 1, 2021July 31, 2026FELDMAN, EVA LUCILLEreporter.nih.gov
Mechanisms of DNA-Specific Autoimmunity in Systemic Lupus ErythematosusNIHNational Institute of Arthritis and Musculoskeletal and Skin Diseases2021 to 2025$2,322,594June 1, 2018September 30, 2025REIZIS, BORISreporter.nih.gov
Transcriptional and Translational Mechanisms Governing Beta Cell FunctionNIHNational Institute of Diabetes and Digestive and Kidney Diseases2022 to 2025$2,322,333March 1, 2002April 30, 2027MIRMIRA, RAGHAVENDRA Greporter.nih.gov
Type I Interferon induction of neuroinflammation mediates neuropsychiatric lupusNIHNational Institute of Arthritis and Musculoskeletal and Skin Diseases2021 to 2025$2,321,217August 18, 2025July 31, 2028CARROLL, MICHAEL CRAIGreporter.nih.gov
Immune Functions of Cutaneous NociceptorsNIHNational Institute of Arthritis and Musculoskeletal and Skin Diseases2021 to 2025$2,315,978March 1, 2017May 31, 2027KAPLAN, DANIEL Hreporter.nih.gov
Tissue-Anchored vs. Circulating Engineered Enzyme Constructs for Immunometabolic Resolution of PsoriasisNIHNational Institute of Allergy and Infectious Diseases2023 to 2025$2,314,029February 2, 2023January 31, 2028KESELOWSKY, BENJAMIN GEORGEreporter.nih.gov
Derivation of pancreatic islet-like organoids from human gastric stem cellsNIHNational Institute of Diabetes and Digestive and Kidney Diseases2022 to 2025$2,313,256August 24, 2022May 31, 2026RAFII, SHAHINreporter.nih.gov
Glial Mechanisms Governing the Removal and Repair of Degenerating MyelinNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$2,312,213September 1, 2021August 31, 2026HILL, ROBERT A.reporter.nih.gov
Rescue of Autoimmune-Associated Long QT Syndrome by Decoy PeptidesNIHNational Heart, Lung, and Blood Institute2022 to 2025$2,309,947August 19, 2022July 31, 2027BOUTJDIR, MOHAMEDreporter.nih.gov
Identification of key regulators in rheumatoid arthritisNIHNational Institute of Arthritis and Musculoskeletal and Skin Diseases2021 to 2024$2,309,449August 1, 2014April 30, 2026WANG, WEIreporter.nih.gov
Regulation of Peripheral Neuropathic Pain by B CellsNIHNational Institute of Neurological Disorders and Stroke2022 to 2025$2,308,227March 15, 2022February 28, 2027GRACE, PETER Mreporter.nih.gov
Gene discoveries in subjects with Crohn's disease of African descentNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2023$2,305,204March 1, 2011June 30, 2025KUGATHASAN, SUBRAreporter.nih.gov
MASPs as therapeutic targets in complement-mediated diseasesNIHNational Institute of Allergy and Infectious Diseases2021 to 2024$2,302,777March 18, 2020February 28, 2025SONG, WENCHAOreporter.nih.gov
Type III interferon Control of Mucosal ImmunityNIHNational Institute of Diabetes and Digestive and Kidney Diseases2023 to 2025$2,301,166August 1, 2017December 31, 2026ZANONI, IVANreporter.nih.gov
T cell Epitope Discovery in SarcoidosisNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,300,582July 5, 2017June 30, 2026PALMER, BRENT Ereporter.nih.gov
Evolution of autoreactive GC and epitope spreading in lupusNIHNational Institute of Arthritis and Musculoskeletal and Skin Diseases2021 to 2025$2,299,924July 13, 2018June 30, 2028CARROLL, MICHAEL CRAIGreporter.nih.gov
Engineering optimization and scaling enables high quality pancreatic islet cryopreservation for banking and transplantNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2024$2,294,596September 22, 2021July 31, 2025FINGER, ERIK BRIANreporter.nih.gov
Mechanisms of autoimmunity in myasthenia gravisNIHNational Institute of Allergy and Infectious Diseases2021 to 2025$2,293,368November 4, 2015August 31, 2026O'CONNOR, KEVIN Creporter.nih.gov
Innate mechanisms of regulation of Th17 responsesNIHNational Institute of Allergy and Infectious Diseases2021 to 2025$2,291,191December 1, 2016December 31, 2026PASARE, CHANDRASHEKHARreporter.nih.gov
Thymic selection abnormalities in Type 1 DiabetesNIHNational Institute of Allergy and Infectious Diseases2023 to 2025$2,291,187June 26, 2023May 31, 2028SYKES, MEGANreporter.nih.gov
Immune Interactions with the Mucus-Associated MicrobiotaNIHNational Institute of Allergy and Infectious Diseases2021 to 2025$2,287,659July 12, 2021June 30, 2027MAYNARD, CRAIG Lreporter.nih.gov
Characterizing and predicting colitis in immune checkpoint blockade-treated cancer patientsNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2024$2,286,893June 1, 2020May 31, 2026GNJATIC, SACHAreporter.nih.gov
Aberrant DNA Repair and LupusNIHNational Institute of Environmental Health Sciences2021 to 2023$2,286,049July 6, 2020March 31, 2024SWEASY, JOANN B.reporter.nih.gov
University of Miami IBD Genetic Research Center: Understanding the Genetic Architecture of IBD in the South Florida communityNIHNational Institute of Diabetes and Digestive and Kidney Diseases2022 to 2025$2,285,492September 30, 2022June 30, 2027MCCAULEY, JACOB Lreporter.nih.gov
Mechanisms controlling ABC differentiation and function in SLENIHNational Institute of Arthritis and Musculoskeletal and Skin Diseases2022 to 2025$2,285,313July 1, 2022May 31, 2027PERNIS, ALESSANDRA Breporter.nih.gov
Biochemical Mechanism of Beta-Cell DestructionNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2025$2,284,193June 1, 2022March 31, 2027CORBETT, JOHN Areporter.nih.gov
Morning Meal-Associated Priming of the LiverNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2024$2,282,667September 24, 2021July 31, 2025CHERRINGTON, ALAN Dreporter.nih.gov
Development of a high-throughput epigenomic mapping platform to molecularly phenotype Crohn's diseaseNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2023$2,282,116September 1, 2022August 31, 2025JOHNSTONE, ANDREA LYNNreporter.nih.gov
Role of Natural Killer Cell Diversity in Multiple Sclerosis Risk and Disease CourseNIHNational Institute of Allergy and Infectious Diseases2022 to 2025$2,281,489September 19, 2022July 31, 2028HOLLENBACH, JILL ALLISONreporter.nih.gov
Diabetes in African Youth: Improving Glucose Time-In-RangeNIHNational Institute of Diabetes and Digestive and Kidney Diseases2022 to 2025$2,281,071April 1, 2022March 31, 2027MORAN, ANTOINETTE M.reporter.nih.gov
High-Intensity, dynamic-stability gait training in people with multiple sclerosisNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2022 to 2025$2,280,989September 15, 2022June 30, 2027SCHMIT, BRIAN Dreporter.nih.gov
Activity Probes to Guide Precision Microbiome TherapyNIHNational Center for Complementary & Integrative Health2024 to 2025$2,279,811September 1, 2024May 31, 2029LONGMAN, RANDY Sreporter.nih.gov
A Novel Immunological-Directed Live Biotherapy Product for Treating Ulcerative ColitisNIHNational Institute of Diabetes and Digestive and Kidney Diseases2022 to 2024$2,277,236July 5, 2022July 31, 2025FANGER, GARYreporter.nih.gov
Genomics of Inflammatory Bowel DiseaseNIHNational Institute of Allergy and Infectious Diseases2021 to 2023$2,275,152September 20, 2019August 31, 2025KOTTYAN, LEAH CLAIREreporter.nih.gov
Integrative and longitudinal multi-omic risk assessment in inflammatory bowel disease progressionNIHNational Institute of Diabetes and Digestive and Kidney Diseases2022 to 2025$2,272,364September 30, 2022June 30, 2027KUGATHASAN, SUBRAreporter.nih.gov
Rip Proteins in Innate Immune SignalingNIHNational Institute of Allergy and Infectious Diseases2021 to 2024$2,272,136December 15, 2008August 31, 2025KELLIHER, MICHELLE ALICEreporter.nih.gov
Immunogenomics and Systems Biology CoreNIHNational Institute of Arthritis and Musculoskeletal and Skin Diseases2022 to 2025$2,270,385March 18, 2022December 31, 2026GUDJONSSON, JOHANN ELIreporter.nih.gov
Investigating How TLR7 Activates and TLR9 Regulates Systemic AutoimmunityNIHNational Institute of Allergy and Infectious Diseases2021 to 2025$2,270,215May 1, 2021April 30, 2026SHLOMCHIK, MARK Jreporter.nih.gov
Reducing innate inflammation in new onset T1D with Lactobacillus plantarumNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2024$2,267,995August 21, 2020May 31, 2026HESSNER, MARTIN Jreporter.nih.gov
Purinergic modulation of the autoimmune vascular phenotypeNIHNational Heart, Lung, and Blood Institute2021 to 2025$2,262,808January 1, 2018December 31, 2027KNIGHT, JASONreporter.nih.gov
Exacerbation of Colitis by EnterobacteriaceaeNIHNational Institute of Allergy and Infectious Diseases2021 to 2025$2,260,715January 15, 2015March 31, 2026BAUMLER, ANDREAS Jreporter.nih.gov
Determining the Intrinsic and Environmental Signal Contributing to Early T1D ProgressionNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2023$2,260,661September 15, 2020June 30, 2025CHEN, SHUIBINGreporter.nih.gov
Humoral Immune Mechanisms of Acute and Chronic Neurologic Sequelae of COVID-19NIHNational Institute of Neurological Disorders and Stroke2022 to 2025$2,260,647February 15, 2022November 30, 2025WILSON, MICHAEL Rreporter.nih.gov
Advanced Statistical Analytics of MRI in MSNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$2,257,955April 1, 2020January 31, 2026SHINOHARA, RUSSELL TAKESHIreporter.nih.gov
Utilizing continuous ketone monitors to enable safe use of SGLT inhibitors in patients with Type 1 DiabetesNIHNational Institute of Diabetes and Digestive and Kidney Diseases2025$2,257,919September 11, 2025August 31, 2028PETTUS, JEREMY Hreporter.nih.gov
Glycolytic metabolites, Calcium entry and Sjogren’s syndromeNIHNational Institute of Dental & Craniofacial Research2022 to 2025$2,257,810September 19, 2022June 30, 2027SINGH, BRIJ Breporter.nih.gov
Defining mechanisms of CD8 T cell exhaustion in T1DNIHNational Institute of Allergy and Infectious Diseases2021 to 2024$2,256,570April 10, 2020March 31, 2026LONG, S ALICEreporter.nih.gov
A stem cell activated cryogel bioscaffold that restores islet bioenergetics while providing oxygen and nutrients at extravascular sites of transplantationNIHNational Institute of Diabetes and Digestive and Kidney Diseases2022 to 2025$2,251,861April 1, 2022March 31, 2027THAKOR, AVNESH SINHreporter.nih.gov
Interrogating the intersection between diet and ocular autoimmunityNIHNational Eye Institute2022 to 2025$2,251,397April 1, 2022March 31, 2027PLAFKER, SCOTT Mreporter.nih.gov
Study of Anti-Malarials in Incomplete Lupus Erythematosus (SMILE)NIHNational Institute of Arthritis and Musculoskeletal and Skin Diseases2021 to 2022$2,249,923February 1, 2017January 31, 2025OLSEN, NANCY Jreporter.nih.gov
University of Minnesota Clinical Center for the Restoration of Impaired Awareness of Hypoglycemia in Type 1 DiabetesNIHNational Institute of Diabetes and Digestive and Kidney Diseases2022 to 2025$2,249,591September 25, 2022December 31, 2027SEAQUIST, ELIZABETH R.reporter.nih.gov
Engineering Tregs for autoimmune diabetes therapyNIHNational Institute of Diabetes and Digestive and Kidney Diseases2025$2,249,376September 5, 2025August 31, 2028FIFE, BRIAN Treporter.nih.gov
Virtual Histology for Assessing MS PathologiesNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$2,247,732December 1, 2020November 30, 2025SONG, SHENG-KWEIreporter.nih.gov
Bacterial adaptions in host-microbe interactions.NIHNational Institute of Allergy and Infectious Diseases2022 to 2025$2,240,628March 11, 2022February 28, 2027CHU, HIUTUNGreporter.nih.gov
Leveraging Community-Academic Partnerships and Social Networks to Disseminate Vaccine-Related Information and Increase Vaccine Uptake Among Black Individuals with Rheumatic DiseasesNIHNational Institute of Arthritis and Musculoskeletal and Skin Diseases2022 to 2024$2,239,160May 10, 2022April 1, 2025RAMSEY-GOLDMAN, ROSALINDreporter.nih.gov
Estrogen-mediated immune regulation in human and experimental inflammatory bowel diseaseNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2025$2,237,890March 1, 2021February 28, 2026GOODMAN, WENDY ANNreporter.nih.gov
Mechanisms that alter lymphatic transport in inflammatory bowel diseaseNIHNational Institute of Allergy and Infectious Diseases2022 to 2025$2,237,567February 7, 2022January 31, 2027RANDOLPH, GWENDALYN Jreporter.nih.gov
Long-term Follow-up of the Systemic Immunosuppressive Therapy for Eye Diseases CohortNIHNational Eye Institute2025$2,236,075May 1, 2004August 31, 2029KEMPEN, JOHN Hreporter.nih.gov
Role of Tim-3:Bat-3 pathway in inducing tolerogenic DCs and peripheral toleranceNIHNational Institute of Allergy and Infectious Diseases2021 to 2025$2,235,780February 3, 2020January 31, 2030KUCHROO, VIJAY K.reporter.nih.gov
Role of Sam68 in Proinflammatory SignalingNIHNational Institute of Diabetes and Digestive and Kidney Diseases2022 to 2025$2,234,964April 1, 2022February 28, 2027RAMAKRISHNAN, PARAMESWARANreporter.nih.gov
Low Dose Interleukin-2 for Regulatory T cell Modulation and the Treatment of Crohn’s DiseaseNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2024$2,232,504September 1, 2020June 30, 2026SNAPPER, SCOTT Breporter.nih.gov
Mechanisms driving extrafollicular polyreactive B cell lineages in partial RAG deficiencyNIHNational Institute of Allergy and Infectious Diseases2021 to 2025$2,232,177September 22, 2021August 31, 2027WALTER, JOLAN ESZTERreporter.nih.gov
Targeting the Integrated Stress Response to Protect Oligodendrocyte lineage CellsNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$2,231,775December 1, 1996December 31, 2024POPKO, BRIAN Jreporter.nih.gov
Binding of Epstein Barr Virus EBNA2 Unifies Multiple Sclerosis Genetic MechanismsNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$2,229,920April 15, 2017March 31, 2028WEIRAUCH, MATTHEW TYSONreporter.nih.gov
Contributions of autophagy-related genes in lupusNIHNational Institute of Allergy and Infectious Diseases2023 to 2025$2,228,235August 18, 2023July 31, 2027NATH, SWAPAN K.reporter.nih.gov
Targeting Tfh Cell Metabolic Regulation in SLE and SLE-Associated AtherosclerosisNIHNational Institute of Allergy and Infectious Diseases2021 to 2024$2,227,644May 20, 2020April 30, 2026RATHMELL, JEFFREY C.reporter.nih.gov
Metabolic regulators of Treg/Th17 balance in CNS autoimmunityNIHNational Institute of Allergy and Infectious Diseases2022 to 2025$2,226,462September 21, 2022July 31, 2027KUCHROO, VIJAY K.reporter.nih.gov
Enabling Fully Automated Closed Loop Control in Type 1 Diabetes Through an Artificial Intelligence Meal Detection Algorithm and PramlintideNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2024$2,222,737August 20, 2021June 30, 2026JACOBS, PETER Greporter.nih.gov
TSPO-PET and MRI Imaging as Novel Imaging Tools for Autoimmune EpilepsyNIHNational Institute of Neurological Disorders and Stroke2022 to 2025$2,221,278May 15, 2022April 30, 2027STERIADE, CLAUDEreporter.nih.gov
CD4 AND CD8 T CELL EPITOPES RECOGNIZED IN AUTOIMMUNE AND AUTOINFLAMMATORY DISEASESNIHNational Institute of Allergy and Infectious Diseases2024 to 2025$2,220,000September 30, 2025September 29, 2026STERN, LAWRENCEreporter.nih.gov
Targeting the eNAMPT/TLR4 pathway to reduce Inflammatory Bowel Disease severityNIHNational Institute of Diabetes and Digestive and Kidney Diseases2022 to 2024$2,219,663September 19, 2022July 31, 2025GARCIA, JOE G. N.reporter.nih.gov
Diabetic Foot Consortium Clinical Research UnitNIHNational Institute of Diabetes and Digestive and Kidney Diseases2023 to 2025$2,218,022September 21, 2018December 31, 2027SEN, CHANDAN Kreporter.nih.gov
Defining the induction and maintenance of myelin-specific tolerance in T cells and B cells using local lymph node depotsNIHNational Institute of Allergy and Infectious Diseases2022 to 2025$2,215,775February 1, 2022January 31, 2027JEWELL, CHRISTOPHER Mreporter.nih.gov
Clinical and Economic Impact of Teleneurology vs Standard in Clinic Care for Multiple Sclerosis: A Randomized TrialNIHNational Institute of Nursing Research2022 to 2025$2,209,310September 26, 2022June 30, 2027MCGINLEY, MARISAreporter.nih.gov
Posttranslational Neoantigens in Autoimmunity and Metabolism in T1DNIHNational Institute of Diabetes and Digestive and Kidney Diseases2023 to 2025$2,209,225January 25, 2023November 30, 2027MAMULA, MARK Jreporter.nih.gov
Systemic immunoregulatory consequences of bacterial translocation during health and diseaseNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2025$2,209,196September 21, 2021June 30, 2026MEISEL, MARLIESreporter.nih.gov

Organizations

OrganizationPlaceNIH awardsNIH amountNSF awardsNSF amount
Benaroya Research Inst at Virginia MasonSeattle, WA42$252.4 million0$0
University of South FloridaTampa, FL13$199.4 million0$0
University of California, San FranciscoSan Francisco, CA117$139.7 million0$0
University of Michigan at Ann ArborAnn Arbor, MI107$127.5 million0$0
University of Colorado DenverAurora, CO120$123.1 million0$0
University of PennsylvaniaPhiladelphia, PA74$113.2 million0$0
Brigham and Women's HospitalBoston, MA91$101.5 million0$0
Stanford UniversityStanford, CA80$100.7 million0$0
Johns Hopkins UniversityBaltimore, MD91$88.7 million0$0
Yale UniversityNew Haven, CT83$87.2 million0$0
Icahn School of Medicine at Mount SinaiNew York, NY52$81.4 million0$0
Emory UniversityAtlanta, GA36$80.6 million0$0
Massachusetts General HospitalBoston, MA77$77 million0$0
Case Western Reserve UniversityCleveland, OH36$75.7 million0$0
University of Pittsburgh at PittsburghPittsburgh, PA67$73.4 million0$0
Columbia University Health SciencesNew York, NY47$69.3 million0$0
Weill Medical Coll of Cornell UnivNew York, NY62$68.5 million0$0
Washington UniversitySaint Louis, MO74$67.2 million0$0
University of UtahSalt Lake City, UT46$63.6 million0$0
University of California, San DiegoLa Jolla, CA59$61.7 million0$0
New York University School of MedicineNew York, NY58$60.5 million0$0
Rho Federal Systems Division, Inc.Durham, NC2$60.5 million0$0
Oklahoma Medical Research FoundationOklahoma City, OK30$60.5 million0$0
Vanderbilt University Medical CenterNashville, TN55$60 million0$0
Cincinnati Childrens Hosp Med CTRCincinnati, OH42$58.1 million0$0
University of ChicagoChicago, IL33$57.6 million0$0
Boston Children's HospitalBoston, MA46$57.2 million0$0
University of FloridaGainesville, FL61$56.7 million0$0
University of WashingtonSeattle, WA49$56.1 million0$0
University of VirginiaCharlottesville, VA37$51.6 million0$0
Univ of North Carolina Chapel HillChapel Hill, NC42$48.5 million0$0
Mayo Clinic RochesterRochester, MN41$48.3 million0$0
University of MinnesotaMinneapolis, MN43$48 million0$0
Northwestern University at ChicagoChicago, IL38$47.5 million0$0
Jaeb Center for Health Research, Inc.Tampa, FL3$47 million0$0
University of Alabama at BirminghamBirmingham, AL59$45.8 million0$0
Cleveland Clinic Lerner Com-CwruCleveland, OH38$45.5 million0$0
Univ of Massachusetts Med SCH WorcesterWorcester, MA32$42.7 million0$0
Duke UniversityDurham, NC42$39.7 million0$0
Ut Southwestern Medical CenterDallas, TX37$38.1 million0$0
Pennsylvania State Univ Hershey Med CTRHershey, PA17$37.7 million0$0
Beckman Research Institute/city of HopeDuarte, CA15$36.6 million0$0
Cedars-Sinai Medical CenterLos Angeles, CA30$33.7 million0$0
Medical University of South CarolinaCharleston, SC32$32.4 million0$0
Hospital for Special SurgeryNew York, NY26$30.3 million0$0
Baylor College of MedicineHouston, TX29$28.5 million0$0
Children's Hosp of PhiladelphiaPhiladelphia, PA21$27.3 million0$0
University of Texas HLTH Science CenterSan Antonio, TX15$27.2 million0$0
University of Miami School of MedicineCoral Gables, FL31$26.5 million0$0
University of California Los AngelesLos Angeles, CA37$25.7 million0$0
Feinstein Institute for Medical ResearchManhasset, NY13$25.7 million0$0
Dartmouth CollegeHanover, NH11$24.9 million0$0
University of Illinois at ChicagoChicago, IL17$24.6 million0$0
Indiana University IndianapolisIndianapolis, IN27$24.2 million0$0
Joslin Diabetes CenterBoston, MA14$23.1 million0$0
Scripps Research Institute, theLa Jolla, CA20$22.9 million0$0
University of RochesterRochester, NY13$22.7 million0$0
Ohio State UniversityColumbus, OH26$21.4 million0$0
Broad Institute, Inc.Cambridge, MA9$20.9 million0$0
University of LouisvilleLouisville, KY9$20.1 million0$0
Rise Therapeutics, LLCRockville, MD10$19.9 million0$0
University of ArizonaTucson, AZ15$19.2 million0$0
University of Wisconsin-MadisonMadison, WI28$18.8 million0$0
University of California at DavisDavis, CA25$18.6 million0$0
Beth Israel Deaconess Medical CenterBoston, MA17$18.4 million0$0
University of Southern CaliforniaLos Angeles, CA18$17.1 million0$0
University of Maryland BaltimoreBaltimore, MD14$16 million0$0
Medical College of WisconsinMilwaukee, WI15$15.8 million0$0
Thomas Jefferson UniversityPhiladelphia, PA13$15.7 million0$0
University of IowaIowa City, IA24$15.1 million0$0
University of Texas HLTH Sci CTR HoustonHouston, TX21$14.5 million0$0
Sage BionetworksSeattle, WA1$14.5 million0$0
University of TX MD Anderson Can CTRHouston, TX13$14.4 million0$0
Albert Einstein College of MedicineBronx, NY18$14 million0$0
University of Missouri-ColumbiaColumbia, MO13$13.9 million0$0
George Washington UniversityWashington, DC8$13.6 million0$0
Oregon Health & Science UniversityPortland, OR21$13.3 million0$0
University of California-IrvineIrvine, CA12$12.4 million0$0
University of Texas Med BR GalvestonGalveston, TX14$12.1 million0$0
Sloan-Kettering Inst Can ResearchNew York, NY8$11.3 million0$0
SUNY at BuffaloAmherst, NY14$11.1 million0$0
Michigan State UniversityEast Lansing, MI12$11.1 million0$0
Seattle Children's HospitalSeattle, WA9$10.7 million0$0
Rutgers Biomedical and Health SciencesNewark, NJ14$10.6 million0$0
National Jewish HealthDenver, CO13$10.5 million0$0
University of Nebraska Medical CenterOmaha, NE8$10.1 million0$0
Wayne State UniversityDetroit, MI11$10 million0$0
Research Inst Nationwide Children's HospColumbus, OH5$10 million0$0
University of HoustonHouston, TX8$9.8 million0$0
Arizona State UniversityScottsdale, AZ8$9.8 million0$0
University of KentuckyLexington, KY8$9.6 million0$0
University of South Carolina at ColumbiaColumbia, SC7$9.4 million0$0
Connecticut Children's Medical CenterHartford, CT3$9.4 million0$0
Methodist Hospital Research InstituteHouston, TX6$9.3 million0$0
La Jolla Institute for ImmunologyLa Jolla, CA7$9.2 million0$0
ST. Jude Children's Research HospitalMemphis, TN3$8.9 million0$0
University of California-BerkeleyBerkeley, CA11$8.4 million0$0
Upstate Medical UniversitySyracuse, NY4$8.3 million0$0
University of Kansas Medical CenterKansas City, KS7$7.8 million0$0
Vanderbilt UniversityNashville, TN15$7.8 million0$0

Funding by fiscal year

Fiscal yearNIH awardsNIH amountNSF awardsNSF amount
20251,717$1,036,792,9080$0
20241,732$924,477,3300$0
20231,777$942,082,7290$0
20221,861$922,390,6700$0
20211,828$925,403,6610$0

Open federal funding opportunities

From Grants.gov: notices that funded awards in this table, and open notices on the same agency and assistance listing.

Open opportunityNumberAgencyListingClosesAward ceilingWhy it matches
Change of Recipient Organization (Type 7 Parent Clinical Trial Optional)PA-24-254NIHJuly 12, 2027Not listedNotice number printed on 30 awards here
Mentored Clinical Scientist Research Career Development Award (Parent K08 Independent Clinical Trial Not Allowed)PA-24-182NIHMay 8, 2027Not listedNotice number printed on 13 awards here
Mentored Patient-Oriented Research Career Development Award (Parent K23 Independent Clinical Trial Not Allowed)PA-24-185NIHMay 7, 2027Not listedNotice number printed on 8 awards here
Mentored Research Scientist Development Award (Parent K01 - Independent Clinical Trial Not Allowed)PA-24-176NIHMay 7, 2027Not listedNotice number printed on 5 awards here
Mentored Patient-Oriented Research Career Development Award (Parent K23 Independent Clinical Trial Required)PA-24-184NIHMay 8, 2027Not listedNotice number printed on 4 awards here
NIH Pathway to Independence Award (Parent K99/R00 Independent Clinical Trial Not Allowed)PA-24-194NIHMay 7, 2027Not listedNotice number printed on 3 awards here
Midcareer Investigator Award in Patient-Oriented Research (Parent K24 Independent Clinical Trial Not Allowed)PA-24-188NIHMay 7, 2027Not listedNotice number printed on 2 awards here
NIH Support for Conferences and Scientific Meetings (Parent R13 Clinical Trial Not Allowed)PA-25-080NIHSeptember 7, 2027Not listedNotice number printed on 2 awards here
Competing Revisions to Existing NIH Single Project Research Grants and Cooperative Agreements (Clinical Trial Optional)PA-23-317NIHNovember 24, 2026Not listedNotice number printed on 1 award here
NIH Exploratory/Developmental Research Project Grant (Parent R21 Clinical Trial Not Allowed)PA-25-304NIHJanuary 7, 2028Not listedNotice number printed on 1 award here
Limited Competition for the Continuation of the Caring for OutPatiEnts after Acute Kidney Injury (COPE-AKI) Clinical Centers (U01 Clinical Trial Required)RFA-DK-27-125NIH93.847November 6, 2026Not listedSame assistance listing 93.847 as 1,250 awards here
Single Source for the Continuation of the Epidemiology of Diabetes Interventions and Complications (EDIC) Study Research Center (Collaborative U01 Clinical Trial Not Allowed)RFA-DK-27-112NIH93.847November 9, 2026Not listedSame assistance listing 93.847 as 1,250 awards here
Single Source for the Continuation of the Caring for OutPatiEnts after Acute Kidney Injury (COPE-AKI) Scientific and Data Research Center (U01 Clinical Trial Required)RFA-DK-27-139NIH93.847November 9, 2026Not listedSame assistance listing 93.847 as 1,250 awards here
Single Source for the Continuation of the Physiology of the Weight Reduced State (POWERS) Study (U01- Clinical Trials Required)RFA-DK-27-122NIH93.847November 17, 2026Not listedSame assistance listing 93.847 as 1,250 awards here
NIH Research Software Engineer (RSE) Award (R50 Clinical Trials Not Allowed)RFA-OD-24-011NIH93.847December 4, 2026Not listedSame assistance listing 93.847 as 1,250 awards here
Small Business Transition Grant for New Entrepreneurs (Parent R43/R44 Clinical Trial Optional)PAR-27-039NIH93.847January 5, 2027Not listedSame assistance listing 93.847 as 1,250 awards here
Intervention Research to Improve Native American Health (R01 Clinical Trial Optional)PAR-25-379NIH93.847January 7, 2027Not listedSame assistance listing 93.847 as 1,250 awards here
HEAL Initiative: Studies to Enable Analgesic Discovery (R61/R33 - Clinical Trial Not Allowed)RFA-NS-25-023NIH93.847January 15, 2027$350,000Same assistance listing 93.847 as 1,250 awards here
Diabetes Research Centers (P30 Clinical Trial Optional)RFA-DK-26-310NIH93.847January 27, 2027$1 millionSame assistance listing 93.847 as 1,250 awards here
NIDDK Multi-Purpose Resource-Related, Multi-Component Research Services Centers Cooperative Agreement (U2C - Clinical Trial Optional)RFA-DK-28-114NIH93.847January 28, 2027Not listedSame assistance listing 93.847 as 1,250 awards here

Updated November 3, 2026. Read from NIH RePORTER ExPORTER and NSF Award Search. Published by NIH and NSF as U.S. government data. NIH awards are fiscal years 2021 to 2025 (NIH files published to 2026-07-09); NSF awards are fiscal years 2022 to 2026 (NSF files published to 2026-11-02). NIH amounts are the total cost of each fiscal year in the window; NSF amounts are the funds obligated in the window. Organizations are matched on the UEI. Open opportunities come from Grants.gov and match on agency and assistance listing number, and on the notice number NIH prints on an award. Free to reuse with credit to SpecStream under CC BY 4.0. Spot a wrong value? Write to [email protected] with the link to this page.