| Alzheimers Disease and Related Disorders Association Inc | 501(c)(3) | 1985 | $457.2 million | $523.7 million | 2025-06 |
| American Lung Association | 501(c)(3) | 1944 | $118.7 million | $225.7 million | 2025-06 |
| Muscular Dystrophy Association | 501(c)(3) | 1952 | $64.2 million | $50.9 million | 2025-12 |
| Aids Foundation of Chicago | 501(c)(3) | 1986 | $41 million | $21.7 million | 2025-06 |
| American Osteopathic Association | 501(c)(3) | 1959 | $35.8 million | $109.1 million | 2025-05 |
| University of Western States | 501(c)(3) | 1950 | $29.1 million | $83.2 million | 2025-05 |
| Chicago House and Social Service Agency | 501(c)(3) | 1986 | $26.4 million | $19.3 million | 2025-06 |
| National Society To Prevent Blindness | 501(c)(3) | 1990 | $14.7 million | $29.2 million | 2025-03 |
| American Society for Surgery of the Hand | 501(c)(3) | 2013 | $12.7 million | $42.5 million | 2024-12 |
| American Epilepsy Society | 501(c)(3) | 1975 | $11.9 million | $22 million | 2025-06 |
| Alzheimers Impact Movement | 501(c)(4) | 2010 | $11.3 million | $859,243 | 2025-06 |
| Alliance NCTN Foundation | 501(c)(3) | 2020 | $10.9 million | $4.5 million | 2024-12 |
| International Council for Veterinary Assessment | 501(c)(3) | 1996 | $10.2 million | $18.9 million | 2025-05 |
| Pulmonary Fibrosis Foundation | 501(c)(3) | 2000 | $9.3 million | $17.5 million | 2025-06 |
| Midwest Asian Health Association - Maha | 501(c)(3) | 2003 | $6 million | $7.8 million | 2025-06 |
| The International Waldenstroms Macroglobulinemia Foundation Inc | 501(c)(3) | 2002 | $4.5 million | $7.5 million | 2024-12 |
| Neurocritical Care Society Inc | 501(c)(3) | 2003 | $4.4 million | $5.9 million | 2025-12 |
| American Association for the Surgery of Trauma | 501(c)(3) | 1979 | $4.1 million | $10.4 million | 2024-12 |
| Joint Review Committee On Education in Radiologic Technology | 501(c)(3) | 1973 | $3.4 million | $6.3 million | 2025-12 |
| Health and Medicine Policy Research Group | 501(c)(3) | 1982 | $3.2 million | $2.7 million | 2024-12 |
| Medical-Surgical Nursing Certification Board Inc | 501(c)(6) | 2008 | $3.2 million | $5 million | 2025-12 |
| Eastern Association for the Surgery of Trauma | 501(c)(3) | 1988 | $2.6 million | $7.6 million | 2025-06 |
| Imerman Angels | 501(c)(3) | 2007 | $2.4 million | $2 million | 2024-12 |
| Mother and Child Alliance | 501(c)(3) | 2003 | $2 million | $1 million | 2025-12 |
| American Academy of Pediatric Dentistry Foundation | 501(c)(3) | 1987 | $1.9 million | $18.8 million | 2025-06 |
| Bernard H Van Der Steen Trust | 501(c)(3) | 1996 | $1.8 million | $2.9 million | 2025-12 |
| Mission Msa | 501(c)(3) | 2001 | $1.8 million | $5 million | 2025-07 |
| The Association of the Jewish Blind of Chicago | 501(c)(3) | 1945 | $1.6 million | $22.6 million | 2025-06 |
| Julie and Michael Tracy Family Foundation | 501(c)(3) | 2012 | $1.4 million | $1.3 million | 2025-06 |
| Usher III Initiative Inc | 501(c)(3) | 2011 | $1.4 million | $2.8 million | 2024-12 |
| American Academy of Periodontology Foundation | 501(c)(3) | 1991 | $1.4 million | $8.5 million | 2024-12 |
| International College of Surgeons Gen Surgeons & Surgical Spec Inc | 501(c)(3) | 1947 | $1.3 million | $567,153 | 2024-12 |
| A Silver Lining Foundation Chicagoland Cancer Info Coalition | 501(c)(3) | 2004 | $1.1 million | $436,643 | 2025-06 |
| American Friends of Gateshead Talmudical College | 501(c)(3) | 2014 | $842,764 | $829,160 | 2024-03 |
| Chicago Medical Society Foundation | 501(c)(3) | 1943 | $788,667 | $4 million | 2024-12 |
| Illinois Society of Dermatologyphysician Assistants | 501(c)(3) | 2009 | $778,538 | $1 million | 2024-12 |
| Recovery On Water Inc | 501(c)(3) | 2009 | $616,356 | $681,060 | 2025-12 |
| American Society of Pediatric Otolaryngology Inc | 501(c)(3) | 1986 | $600,166 | $2.8 million | 2024-12 |
| National Rosacea Society | 501(c)(3) | 1997 | $439,080 | $185,514 | 2025-12 |
| Asociacion Latina de Asistencia Y Prevencion Del Cancer de Mama | 501(c)(3) | 2012 | $419,413 | $840,926 | 2025-12 |
| Henry Schueler 41 & 9 Foundation | 501(c)(3) | 2008 | $346,867 | $952,117 | 2025-12 |
| International Association of Oral and Maxillofacial Surgeons FDN | 501(c)(3) | 1998 | $335,240 | $1.4 million | 2024-12 |
| Illinois Spina Bifida Association | 501(c)(3) | 1971 | $268,168 | $348,197 | 2024-12 |
| Rainbows in Gastro | 501(c)(3) | 2024 | $261,175 | $194,953 | 2025-12 |
| Bleeding Disorders Alliance Illinoi S | 501(c)(3) | 1997 | $251,972 | $620,365 | 2024-12 |
| Vaughn McClure and Jeff Dickerson Foundation | 501(c)(3) | 2022 | $191,727 | $340,129 | 2024-12 |
| Face the Future Foundation | 501(c)(3) | 2006 | $155,418 | $170,640 | 2025-06 |
| United Colors of Pink | 501(c)(3) | 2020 | $146,487 | $85,038 | 2025-12 |
| Lamplighters Orthopaedic Association | 501(c)(3) | 2024 | $126,537 | $72,452 | 2025-12 |
| Chicago Lower Extremity Surgical Foundation | 501(c)(3) | 2014 | $86,239 | $148,562 | 2023-12 |
| Cares for Cancer NFP | 501(c)(3) | 2024 | $84,844 | $96,055 | 2025-12 |
| Margaret Hackett Family Center NFP | 501(c)(3) | 2018 | $82,860 | $600,564 | 2025-06 |
| American Academy of Neurological & Orthopaedic Surgery | 501(c)(3) | 1978 | $79,365 | $405,859 | 2025-12 |
| Endpreeclampsia Inc | 501(c)(3) | 2026 | $77,783 | $64,257 | 2024-12 |
| Crsa Clinical Robotic Surgery Association | 501(c)(3) | 2012 | $63,111 | $172,196 | 2025-12 |
| Illinois Society of Genetic Professionals | 501(c)(3) | 2020 | $56,100 | $68,023 | 2024-12 |
| Foundation for Dermatology Education | 501(c)(3) | 2020 | $56,000 | $459,694 | 2025-12 |
| Patrick Grange Memorial Foundation NFP | 501(c)(3) | 2014 | $38,310 | $38,539 | 2025-12 |
| Latino Alzheimers Coalition for Advocacy Research and Education | 501(c)(3) | 2022 | $26,599 | $28,670 | 2025-12 |
| Mary E Smith - M O M - Foundation Inc - Memories of Mary | 501(c)(3) | 2009 | $21,899 | $10,777 | 2024-12 |
| Chicago Arthroplasty Alumni Foundation | 501(c)(3) | 2013 | $13,837 | $120,704 | 2025-11 |
| Power Vision and Wellness Center NFP | 501(c)(3) | 2020 | $13,500 | $10,272 | 2024-12 |
| American College of Wound Healing and Tissue Repair | 501(c)(3) | 2012 | $4,000 | $95,505 | 2025-12 |
| A Town Foundation | 501(c)(3) | 2020 | $0 | $0 | 2025-12 |
| Abejas Pequenas | 501(c)(3) | 2023 | $0 | $0 | 2024-12 |
| Abf Cares Foundation | 501(c)(3) | 2026 | | | |
| American Association of Osteopathic Examiners | 501(c)(3) | 2014 | $0 | $0 | 2026-05 |
| American Friends of the Intl Union Agnst Tuberculosis & Lung Disease | 501(c)(3) | 2022 | $0 | $0 | 2025-12 |
| Asian Pharmacists Association | 501(c)(3) | 2023 | $0 | $0 | 2024-12 |
| Association for Vascular Access | 501(c)(6) | 2010 | $0 | $0 | 2024-12 |
| Autism Therapy Project | 501(c)(3) | 2020 | $0 | $0 | 2024-12 |
| Behavioral Research in Diabetes Group Exchange | 501(c)(3) | 2002 | $0 | $0 | 2025-06 |
| Beyond the 4 Walls Outreach Inc | 501(c)(3) | 2025 | $0 | $0 | 2025-11 |
| Bianca Cacciatore Legacy Foundation | 501(c)(3) | 2026 | | | |
| Cancer Care Americas NFP | 501(c)(3) | 2019 | $0 | $0 | 2025-12 |
| Cancer Foundation for Minority Andundeserved Populations | 501(c)(3) | 2008 | $0 | $0 | 2025-12 |
| Cansoar Foundation | 501(c)(3) | 2025 | | | |
| Charlies Way To Infinity and Beyond Foundation | 501(c)(3) | 2025 | | | |
| Chemo Courage Bags Inc | 501(c)(3) | 2025 | $0 | $0 | 2025-12 |
| Chicago Pediatric Society | 501(c)(3) | 1972 | $0 | $0 | 2024-06 |
| Childrens Place Association | 501(c)(3) | 1998 | | | |
| Dads and Donts | 501(c)(3) | 2025 | $0 | $0 | 2025-12 |
| Devontae Kool Barton Foundation NFP | 501(c)(3) | 2022 | $0 | $0 | 2025-12 |
| Different Shades of Pink | 501(c)(3) | 2012 | $0 | $0 | 2024-12 |
| Directors of Clinical Skills Education | 501(c)(3) | 2015 | $0 | $0 | 2025-12 |
| Easter Seals Foundation | 501(c)(3) | 2007 | $0 | $0 | 2025-12 |
| Elevated Survivorship | 501(c)(3) | 2019 | $0 | $0 | 2026-06 |
| FR John Kolkman Foundation | 501(c)(3) | 2014 | $0 | $0 | 2024-12 |
| First Principles Foundation | 501(c)(3) | 2026 | | | |
| GH Foundation | 501(c)(3) | 2022 | | $102,464 | 2025-12 |
| Gamers for Alzheimers Cure Foundation | 501(c)(3) | 2015 | | | |
| Gift of Sight Foundation | 501(c)(3) | 2024 | $0 | $0 | 2025-12 |
| Girl Love On You Foundation | 501(c)(3) | 2026 | | | |
| Goals and Rainbows Cancer Awareness Group NFP | 501(c)(3) | 2023 | $0 | $0 | 2024-12 |
| Gracious Gladiolus | 501(c)(3) | 2023 | $0 | $0 | 2023-12 |
| Health Research and Awareness NFP | 501(c)(3) | 2017 | $0 | $0 | 2024-12 |
| Ida Brechtel CHRTBL Trust Ua | 501(c)(3) | 2001 | | $3.4 million | 2025-07 |
| Illinois Association for Music Therapy | 501(c)(3) | 2016 | $0 | $0 | 2025-12 |
| Illinois Developmental Therapy Association Idta | 501(c)(6) | 2024 | $0 | $0 | 2025-12 |
| Illinois State Neurosurgical Society Inc | 501(c)(6) | 2010 | $0 | $0 | 2024-12 |
| Inclusive Eats | 501(c)(3) | 2025 | | | |
| Inga Cancer Foundation | 501(c)(3) | 2016 | $0 | $0 | 2025-12 |
| Inspired By Faith Inc | 501(c)(3) | 2025 | | | |
| J A Lockett Social Enterprise Inc | 501(c)(3) | 2025 | | | |
| John Fox Memorial Comedians Cancer Screening Fund | 501(c)(3) | 2012 | $0 | $0 | 2025-12 |
| Kays Korner Foundation | 501(c)(3) | 2022 | $0 | $0 | 2024-12 |
| Ko Breast Cancer | 501(c)(3) | 2013 | $0 | $0 | 2024-01 |
| Kuo Charitable Foundation Inc | 501(c)(3) | 2014 | | $6,070 | 2025-12 |
| Leep Beyond NFP | 501(c)(3) | 2014 | $0 | $0 | 2025-12 |
| Making A Daily Effort | 501(c)(3) | 2009 | $0 | $0 | 2025-08 |
| Mary S Room | 501(c)(3) | 2009 | $0 | $648 | 2023-12 |
| Mayer-Rothschild Foundation | 501(c)(3) | 2016 | | $10.1 million | 2024-12 |
| Nextgen Care Foundation | 501(c)(3) | 2026 | | | |
| North American Society of Head and Neck Pathology | 501(c)(3) | 2005 | $0 | $0 | 2025-12 |
| PKRUZZ&FAITH Foundation Incorporated | 501(c)(3) | 2019 | $0 | $0 | 2025-12 |
| Pat Macs Pack Inc | 501(c)(3) | 2014 | | $28,742 | 2025-12 |
| Pennsylvania Dietetic Association | 501(c)(3) | 1968 | $0 | $0 | 2025-05 |
| Rise With Blue NFP | 501(c)(3) | 2026 | | | |
| Sally Guzowski Foundation | 501(c)(3) | 2019 | | $690,395 | 2025-12 |
| Sisters Embracing Life | 501(c)(3) | 2002 | $0 | $0 | 2025-12 |
| Spinal Cord Injury Sucks NFP | 501(c)(3) | 2008 | $0 | $0 | 2024-12 |
| Standonhisword | 501(c)(3) | 2026 | | | |
| Taking Out Toxo | 501(c)(3) | 2016 | $0 | $0 | 2025-06 |
| Tamyras Dream Foundation | 501(c)(3) | 2023 | $0 | $0 | 2023-12 |
| The Pretty Girl Project | 501(c)(3) | 2016 | $0 | $0 | 2025-04 |
| Unico Health NFP | 501(c)(3) | 2023 | $0 | $0 | 2025-12 |
| Unique Sweets Inc NFP | 501(c)(3) | 2022 | $0 | $0 | 2025-12 |
| United Federation of Osteopathic Societies Inc | 501(c)(6) | 2019 | $0 | $0 | 2025-12 |
| Vosh - Illinois Inc | 501(c)(3) | 2011 | $0 | $0 | 2025-12 |
| Warriors Talk | 501(c)(3) | 2022 | $0 | $0 | 2025-06 |
| Windmill & Co Comforts | 501(c)(3) | 2026 | | | |
| World Federation of Neurosurgical Societies USA | 501(c)(3) | 2014 | $0 | $0 | 2025-12 |
| Women in Endocrinology Inc | 501(c)(3) | 1999 | $-13,418 | $160,351 | 2024-12 |