| Lee Memorial Health System Foundation Inc | 501(c)(3) | 1996 | $41.6 million | $114.3 million | 2025-09 |
| Southwest Florida Community Foundation Inc | 501(c)(3) | 1976 | $31.4 million | $183.5 million | 2025-06 |
| United Way of Lee County Inc | 501(c)(3) | 1964 | $27 million | $14.9 million | 2024-12 |
| Florida Gulf Coast University Financing Corporation | 501(c)(3) | 2003 | $20.7 million | $175.7 million | 2025-06 |
| The Legacy Foundation at Shell Point Inc | 501(c)(3) | 2002 | $4.4 million | $5.2 million | 2025-06 |
| SWFL Childrens Charities Inc | 501(c)(3) | 2008 | $3.1 million | $1.3 million | 2025-06 |
| Bobby Nichols-Fiddlesticks Foundation Inc | 501(c)(3) | 2003 | $1.9 million | $736,832 | 2025-12 |
| New Next Level Holdings Inc | 501(c)(2) | 2019 | $610,756 | $18.3 million | 2024-12 |
| Horizon Foundation Inc | 501(c)(3) | 2000 | $600,423 | $768,991 | 2024-12 |
| Millennium Cares Fund Inc | 501(c)(3) | 2022 | $363,076 | $215,533 | 2024-12 |
| The Project Dentists Care Foundation Inc | 501(c)(3) | 2023 | $201,773 | $201,773 | 2024-12 |
| Nate Edwards Annual Fishing Tournament Inc | 501(c)(3) | 2023 | $155,572 | $75,613 | 2025-12 |
| Fort Myers Rotary 05202010 Trust Fund | 501(c)(3) | 2011 | $121,900 | $737,620 | 2025-06 |
| Southwest Florida Gwi Housing II Inc | 501(c)(3) | 1997 | $109,095 | $568,403 | 2025-12 |
| O Bannon Snook Tournament at Cabbage Key Inc | 501(c)(3) | 1996 | $100,992 | $15,250 | 2023-11 |
| Stardust Memories Big Band Inc | 501(c)(3) | 2014 | $98,948 | $44,052 | 2025-08 |
| Royal Palm Coast Realtor Association Crisis Foundation Inc | 501(c)(3) | 2009 | $94,402 | $529,007 | 2025-12 |
| Colonial Charitable Foundation Inc | 501(c)(3) | 2018 | $73,961 | $135,936 | 2025-12 |
| Scott Fischer Charities Inc | 501(c)(3) | 2007 | $66,511 | $74,037 | 2024-12 |
| Lee County Bar Association Foundation Inc | 501(c)(3) | 2017 | $58,072 | $87,938 | 2025-12 |
| Lewis P Tabarrini Childrens Music Foundation Inc | 501(c)(3) | 2012 | $35,122 | $37,764 | 2026-07 |
| Acker Family Foundation Inc | 501(c)(3) | 1998 | | $878,520 | 2025-12 |
| Al-Khalidi Foundation | 501(c)(3) | 1995 | | $589,638 | 2025-12 |
| Almira Family Foundation | 501(c)(3) | 2006 | | $16.6 million | 2024-12 |
| Asher Family Foundation Inc | 501(c)(3) | 2018 | | $1.9 million | 2025-12 |
| Baba Foundation Inc | 501(c)(3) | 2025 | | $6 million | 2024-12 |
| Babich Family Foundation | 501(c)(3) | 2017 | | $39,008 | 2021-12 |
| Blazer Family Charitable Foundation | 501(c)(3) | 2018 | | $1 | 2023-12 |
| Calusa Sportsman Foundation Inc | 501(c)(3) | 2021 | | $1,059 | 2024-12 |
| Carol B Phelon Foundation | 501(c)(3) | 2017 | | $18.5 million | 2025-12 |
| Caroline and William Bloomhall Fami Ly Foundation | 501(c)(3) | 2026 | | $176,523 | 2025-12 |
| Cliff and Georganne Williams Family Foundation Inc | 501(c)(3) | 2016 | | $2.6 million | 2024-12 |
| Colonnade Foundation | 501(c)(3) | 2023 | | $3 million | 2025-12 |
| Cornerstone Community Foundation | 501(c)(3) | 2023 | | | |
| Corsu Cares Foundation Corp | 501(c)(3) | 2018 | $0 | $0 | 2024-12 |
| Cypress Foundation of Southwest Florida Inc | 501(c)(3) | 2026 | $0 | $0 | 2025-09 |
| Daniel R & Anne M Harper Foundation Inc | 501(c)(3) | 2001 | | $12.6 million | 2025-12 |
| David and Mary Reardon Family Foundation Inc | 501(c)(3) | 2009 | | $132,110 | 2025-12 |
| Devries Family Foundation Inc | 501(c)(3) | 2025 | | | |
| Duane R and Carolyn A Swanson Family Foundation Inc | 501(c)(3) | 2022 | | $247,344 | 2025-12 |
| Edison Park School Foundation Inc | 501(c)(3) | 1995 | $0 | $0 | 2025-09 |
| Eileen & Lex Roulston Foundation | 501(c)(3) | 2004 | | $151,980 | 2026-01 |
| Ellington Family Charitable Foundation | 501(c)(3) | 2004 | | $115,797 | 2025-11 |
| Fernandez Family Foundation Inc | 501(c)(3) | 1995 | | $5.1 million | 2025-11 |
| Fetch Foundation Inc | 501(c)(3) | 2025 | | | |
| Fischer Family Foundation Inc | 501(c)(3) | 2015 | | $1.2 million | 2024-12 |
| Five Sun Charities Inc | 501(c)(3) | 2022 | $0 | $0 | 2025-12 |
| Fort Myers Kiwanis Foundation Inc | 501(c)(3) | 2013 | $0 | $0 | 2025-09 |
| Fort Myers Lions Foundation Inc | 501(c)(3) | 2000 | $0 | $0 | 2026-06 |
| Foundation for Christianrelationships Inc | 501(c)(3) | 2007 | | $1 | 2024-12 |
| Fred & Jean Allegretti Foundation Inc | 501(c)(3) | 1998 | | $15.2 million | 2025-10 |
| Friends-4-Cures | 501(c)(3) | 2003 | $0 | $0 | 2025-06 |
| G & G Darehshori Foundation Inc | 501(c)(3) | 1999 | | $9,166 | 2024-12 |
| Garuda Family Foundation | 501(c)(3) | 2013 | | $24,678 | 2025-12 |
| Hawkins Family Foundation Inc | 501(c)(3) | 2025 | | $1.7 million | 2025-12 |
| Help To Others Foundation Inc | 501(c)(3) | 2018 | $0 | $0 | 2024-12 |
| Heritage Cove Womens Club | 501(c)(7) | 2023 | $0 | $0 | 2025-12 |
| Hope for Tomorrow Inc | 501(c)(3) | 2024 | | $1 | 2025-12 |
| Hot Flashz Inc | 501(c)(3) | 2007 | $0 | $0 | 2025-12 |
| Idelson Family Foundation Trust DTD 7-1-11 | 501(c)(3) | 2012 | | $1.3 million | 2025-12 |
| International Childrens Support Foundation Inc | 501(c)(3) | 2007 | $0 | $0 | 2025-12 |
| J Millz Foundation Inc | 501(c)(3) | 2022 | $0 | $0 | 2023-12 |
| Jack Zentz Foundation | 501(c)(3) | 2021 | | $80,000 | 2025-12 |
| John A Carbona Foundation Inc | 501(c)(3) | 2019 | | $1 | 2025-12 |
| Joseph N Capaldo Foundation 03232000 | 501(c)(3) | 2000 | | $51,099 | 2025-12 |
| Joseph R Catti and Jo Ann M Catti Family Foundation | 501(c)(3) | 2022 | | $495,645 | 2025-12 |
| Kennedy Four Family Foundation | 501(c)(3) | 2025 | | | |
| Kent Family Charitable Foundation | 501(c)(3) | 2001 | | $56,200 | 2025-12 |
| Kindlee Inc | 501(c)(3) | 2019 | $0 | $0 | 2025-12 |
| Lancellot Family Foundation Inc | 501(c)(3) | 2023 | | $3.6 million | 2025-12 |
| Lawrence and Phyllis Sager Family Foundation Inc | 501(c)(3) | 2026 | | $1.1 million | 2025-12 |
| Lawson Family Charitable Foundation | 501(c)(3) | 1998 | | $6.5 million | 2025-12 |
| Lets Talk About Children Foundation Corp | 501(c)(3) | 2007 | $0 | $0 | 2025-12 |
| Lloyd Family Foundation | 501(c)(3) | 2019 | | $5.1 million | 2025-12 |
| Los Gatos Foundation Inc | 501(c)(3) | 2025 | | $3.1 million | 2025-12 |
| Madis Miracles | 501(c)(3) | 2026 | | | |
| Manone Family Foundation | 501(c)(3) | 2018 | | $481,759 | 2024-12 |
| Maurya India Foundation | 501(c)(3) | 2023 | $0 | $0 | 2024-12 |
| Miata Club of Southwest Florida | 501(c)(7) | 2016 | $0 | $0 | 2024-12 |
| Miguel C Fernandez III Hispanic Bar Association Inc | 501(c)(3) | 2020 | $0 | $0 | 2024-12 |
| Nanda Eductional Charitable Trust | 501(c)(3) | 2019 | | $1.9 million | 2025-12 |
| National Association of Charitable Gift Planners | 501(c)(3) | 1992 | $0 | $0 | 2025-12 |
| Nellans Family Foundation | 501(c)(3) | 2024 | | $205,919 | 2025-12 |
| Nu Mu Sigma Chapter of Phi Beta Sigma Inc | 501(c)(3) | 2024 | $0 | $0 | 2025-12 |
| Omega Youth & Community Development Foundation Inc | 501(c)(3) | 1991 | $0 | $0 | 2025-12 |
| Orkin Kay Family Foundation Inc | 501(c)(3) | 1997 | | $890,953 | 2025-12 |
| Parikh Foundation | 501(c)(3) | 2015 | | $1.5 million | 2025-12 |
| Park Family Foundation | 501(c)(3) | 2007 | | $4.6 million | 2025-12 |
| Patten Family Foundation | 501(c)(3) | 2001 | | $280,464 | 2025-12 |
| Pulse of Hope Inc | 501(c)(3) | 2024 | | | |
| Quinton B and Beverly H McNew Foundation Inc | 501(c)(3) | 1995 | | $1.7 million | 2025-12 |
| Riverdale High School International Baccalaureate Parents Organization | 501(c)(3) | 2014 | $0 | $0 | 2026-06 |
| Robers Foundation Inc | 501(c)(3) | 2022 | | $23,460 | 2025-12 |
| Robert C and Jane E Holder Foundation Inc | 501(c)(3) | 2000 | | $824,538 | 2025-12 |
| Rotary Club of Fort Myers Sunrise Foundation Inc | 501(c)(3) | 2022 | $0 | $0 | 2025-06 |
| Rubenstein Family Foundation Inc | 501(c)(3) | 2023 | | $4.4 million | 2025-12 |
| Rudlaff Family Foundation | 501(c)(3) | 1998 | | $180,708 | 2025-12 |
| SKL Logan Family Foundation Inc | 501(c)(3) | 2005 | | $1.4 million | 2024-12 |
| Sadako K Judd Private Foundation Inc | 501(c)(3) | 1998 | | $1.9 million | 2025-12 |
| Schweiger Family Charitable Trust | 501(c)(3) | 2019 | | $787,685 | 2026-06 |
| Society of Gastroenterology Nurses and Associates Inc | 501(c)(6) | 1999 | | | |
| Southwest Florida Lacrosse Club Inc | 501(c)(3) | 2016 | $0 | $0 | 2024-12 |
| Springer Foundation Inc | 501(c)(3) | 2015 | | $197,810 | 2025-12 |
| Sumati Inc | 501(c)(3) | 2017 | $0 | $0 | 2025-05 |
| Thatcher Family Foundation Inc | 501(c)(3) | 2026 | | $233,687 | 2025-12 |
| The Carson Family Foundation Inc | 501(c)(3) | 1996 | | $947,051 | 2025-12 |
| The MRS Bunny Foundation | 501(c)(3) | 1995 | | $298,548 | 2024-12 |
| The Unrein Family Foundation Inc | 501(c)(3) | 2026 | | | |
| Thomas and Patricia Englin Foundation | 501(c)(3) | 2022 | | $886,405 | 2025-12 |
| Tommy and Trudy Williams Foundation | 501(c)(3) | 2010 | | $173,093 | 2025-12 |
| Transformation Foundation | 501(c)(3) | 2011 | $0 | $0 | 2023-12 |
| Tripp Family Foundation Inc | 501(c)(3) | 2022 | | $1,230 | 2024-12 |
| Vineyard Foundation | 501(c)(3) | 1995 | | $1.4 million | 2025-12 |
| Water4allproject | 501(c)(3) | 2024 | $0 | $1 | 2025-12 |
| Wei Family Foundation Inc | 501(c)(3) | 2015 | | $1.2 million | 2025-10 |
| Whiteys Foundation Inc | 501(c)(3) | 2023 | | $987,419 | 2025-12 |