Data / Nonprofits / South Carolina / Science and technology
Science and technology nonprofits in South Carolina: 66 registered with the IRS
66 science and technology nonprofits are registered with the IRS in South Carolina, 63 of them 501(c)(3) charities; the 20 that report revenue took in $4.96 billion. The most are in Columbia (17), Charleston (9), Greenville (6). The largest by revenue: Advanced Technology International ($4.87 billion), National Council of Examiners for Engineering and Surveying ($45.7 million), South Carolina Research Authority ($16.2 million).
SpecStream is the live web data engine for teams and agents. It reads the IRS register of exempt organizations as the IRS updates it, and this page is that reading. Ask for the nonprofits you need by place, cause and size, with their latest Form 990 figures and websites, and they arrive in your sheet, CRM, Slack or agent.
Every organization, largest by revenue first
| Organization | City | Type | Since | Revenue | Assets | Filing |
|---|---|---|---|---|---|---|
| Advanced Technology International | Summerville | 501(c)(3) | 1998 | $4.87 billion | $2.19 billion | 2025-09 |
| National Council of Examiners for Engineering and Surveying | Greenville | 501(c)(3) | 1953 | $45.7 million | $107.9 million | 2025-09 |
| South Carolina Research Authority | Columbia | 501(c)(3) | 1987 | $16.2 million | $101.5 million | 2023-06 |
| One Nation Innovation | Columbia | 501(c)(3) | 2022 | $13 million | $2.2 million | 2024-12 |
| SC Thrive | Columbia | 501(c)(3) | 2014 | $8 million | $9.4 million | 2025-12 |
| University Industry Demonstration Partnership Inc | Columbia | 501(c)(3) | 2015 | $4.3 million | $2 million | 2025-06 |
| Ncees Foundation | Greenville | 501(c)(3) | 2025 | $3.2 million | $11.8 million | 2025-09 |
| Palmetto Innosphere Inc | Piedmont | 501(c)(3) | 2024 | $384,000 | $215,909 | 2025-12 |
| World of Euc | Mt Pleasant | 501(c)(6) | 2024 | $239,597 | $33,183 | 2025-12 |
| Charleston Center for Paleontology | Charleston | 501(c)(3) | 2024 | $221,021 | $92,189 | 2024-12 |
| South Carolina Engineering Conference | Columbia | 501(c)(6) | 2012 | $108,803 | $21,515 | 2025-10 |
| National Science and Engineering Alliance Inc | Lake City | 501(c)(3) | 2022 | $97,516 | $27,454 | 2024-12 |
| VC Expeditions | Charleston | 501(c)(3) | 2025 | $85,000 | $15,985 | 2025-12 |
| South Coast Cyber Center Inc | Beaufort | 501(c)(3) | 2020 | $82,596 | $127,781 | 2025-06 |
| Innovision Awards Organization | Greenville | 501(c)(3) | 2011 | $76,585 | $19,523 | 2025-12 |
| American Chemical Society | Aiken | 501(c)(3) | 1946 | $71,283 | $501,213 | 2025-12 |
| CDC Education Foundation | Charleston | 501(c)(3) | 2015 | $65,499 | $107,805 | 2025-12 |
| Archeological Institute of the Pee Dee | Florence | 501(c)(3) | 2022 | $58,300 | $49,713 | 2025-06 |
| International Mechanical Diagnosis and Therapy Research Foundation | Blythewood | 501(c)(3) | 2006 | $22,967 | $394,646 | 2025-12 |
| SC Division of the International Association for Identification | Charleston | 501(c)(3) | 2017 | $16,709 | $32,593 | 2024-12 |
| Ascue Inc | Conway | 501(c)(3) | 1985 | $0 | $0 | 2025-06 |
| Association for Computing Machinery | Spartanburg | 501(c)(3) | 1968 | |||
| Beyond the Lecture | Simpsonville | 501(c)(3) | 2021 | $0 | $0 | 2025-12 |
| Building Enclosure Council -Charleston | Summerville | 501(c)(3) | 2025 | $0 | $0 | 2025-12 |
| Carolina Institute of Technology | Columbia | 501(c)(3) | 2017 | $0 | $0 | 2023-12 |
| Center of Excellence for Research and Program Innovation | Denmark | 501(c)(3) | 2025 | |||
| Cola Makerspace | Columbia | 501(c)(3) | 2015 | $0 | $0 | 2025-12 |
| Comprehensive Community Based Solutions Inc | Rock Hill | 501(c)(3) | 2006 | $0 | $0 | 2025-12 |
| Design Build Fly at Clemson | Columbia | 501(c)(3) | 2023 | $0 | $0 | 2025-06 |
| Eastern Section of the Sepm Society for Sedimentary Geology | Charleston | 501(c)(6) | 2015 | $0 | $0 | 2025-12 |
| Eco 180 | Inman | 501(c)(3) | 2025 | $0 | $0 | 2025-12 |
| Engineering Leadership | Daniel Island | 501(c)(3) | 2021 | $1,149 | 2024-12 | |
| Environmentally Sustainable Materials Institute | Ridgeland | 501(c)(3) | 2024 | |||
| Ernest Everett Just Charleston Chapter | Mt Pleasant | 501(c)(3) | 2022 | $0 | $0 | 2025-12 |
| Following Seas Marine Impact Resear CH Inc | Ravenel | 501(c)(3) | 2026 | |||
| Foundation for Southeastern Fish and Wildlife Agencies | Aiken | 501(c)(3) | 2018 | $0 | $14,642 | 2024-12 |
| Gaming for Hope Inc | Conway | 501(c)(3) | 2025 | $0 | $0 | 2025-12 |
| Hands On Prosthetic Engineering Hope | Columbia | 501(c)(3) | 2017 | $0 | $0 | 2025-12 |
| Isc2 Charleston Chapter | Daniel Island | 501(c)(3) | 2024 | $0 | $0 | 2025-12 |
| Lewis Ai & Data Science Center Inc | Charleston | 501(c)(3) | 2025 | |||
| Lowcountry Innovation Alliance | Walterboro | 501(c)(3) | 2026 | |||
| Lowcountry Institute for Future Technologies Inc | Sheldon | 501(c)(3) | 2002 | $0 | $0 | 2025-12 |
| Lowcountry Stargazers | Charleston | 501(c)(3) | 2015 | $0 | $0 | 2025-12 |
| Lowcountry Stem Collaborative | Charleston | 501(c)(3) | 2020 | $0 | $42,231 | 2025-06 |
| Midlands Astronomy Club Inc | Columbia | 501(c)(3) | 2016 | $0 | $0 | 2025-12 |
| Millyard Operations Technical Advancement Group | Lexington | 501(c)(3) | 2017 | $0 | $0 | 2025-01 |
| National Society of Black Engineers | Columbia | 501(c)(3) | 1988 | $0 | $0 | 2025-07 |
| National Society of Black Engineers | N Charleston | 501(c)(3) | 1988 | $0 | $0 | 2024-07 |
| National Society of Black Engineers | North Augusta | 501(c)(3) | 1988 | $0 | $0 | 2026-07 |
| North Carolina Quantum Association | Columbia | 501(c)(3) | 2025 | |||
| Parker & Parker | Myrtle Beach | 501(c)(3) | 2025 | |||
| Richard T Greener Institute for Social Policy | Columbia | 501(c)(3) | 2014 | $34,099 | 2025-12 | |
| Savannah River Section of the Amer Nuclear Society Incorporated Term | Aiken | 501(c)(3) | 2013 | $0 | $0 | 2025-12 |
| Savannah River Site Women in Nuclea R | North Augusta | 501(c)(3) | 2026 | |||
| Scbio Foundation | Greenville | 501(c)(3) | 2004 | $0 | $31,139 | 2025-12 |
| South Carolina Academy of Science | Columbia | 501(c)(3) | 1964 | $0 | $0 | 2026-06 |
| South Carolina Archaeology Public Outreach Division Inc | Columbia | 501(c)(3) | 2012 | $0 | $0 | 2025-12 |
| South Carolina Entomological Society | Columbia | 501(c)(3) | 2003 | $0 | $0 | 2025-12 |
| South Carolina Society of Nuclear Medicine | West Columbia | 501(c)(3) | 2015 | $0 | $0 | 2026-06 |
| Southeastern Universities Nuclear Reactors Institute for Science and | Aiken | 501(c)(3) | 2009 | $0 | $0 | 2025-06 |
| Symposium On Stimuli-Responsive Materials | Clemson | 501(c)(3) | 2015 | $0 | $0 | 2026-01 |
| Technology Research Services | Columbia | 501(c)(3) | 2016 | $0 | $0 | 2025-12 |
| Upstate South Carolina General Mobile Radio Service Group Inc | Pickens | 501(c)(3) | 2025 | |||
| Wikiciv Org Inc | Greenville | 501(c)(3) | 2024 | $0 | $0 | 2024-12 |
| Women Life and Science | Greenville | 501(c)(3) | 2023 | $0 | $0 | 2025-12 |
| Wxsphere Inc | Charleston | 501(c)(3) | 2026 |
Every nonprofit in South Carolina
Read from the IRS Exempt Organizations Business Master File, updated by the IRS on October 24, 2026 and rebuilt here every morning. Revenue and assets are from each organization's latest filing as the IRS lists it; the IRS record is the official one. Organizations only: no people are named on these pages.