Data / Nonprofits / South Carolina / Human services
Human services nonprofits in South Carolina: 2,596 registered with the IRS
2,596 human services nonprofits are registered with the IRS in South Carolina, 2,576 of them 501(c)(3) charities; the 813 that report revenue took in $1.31 billion. The most are in Columbia (300), Greenville (144), Charleston (99). The largest by revenue: Lutheran Homes of South Carolina Inc ($94.6 million), Presbyterian Communities of South Carolina ($87.6 million), Bishop Gadsden Episcopal Retirement Community ($83.5 million).
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The 500 largest by revenue
| Organization | City | Type | Since | Revenue | Assets | Filing |
|---|---|---|---|---|---|---|
| Lutheran Homes of South Carolina Inc | Irmo | 501(c)(3) | 1942 | $94.6 million | $124.5 million | 2025-09 |
| Presbyterian Communities of South Carolina | Columbia | 501(c)(3) | 1959 | $87.6 million | $183.7 million | 2025-12 |
| Bishop Gadsden Episcopal Retirement Community | Charleston | 501(c)(3) | 1943 | $83.5 million | $387.5 million | 2025-12 |
| Palmetto Goodwill | Charleston | 501(c)(3) | 2015 | $65.1 million | $137.2 million | 2024-12 |
| Babcock Center Inc | West Columbia | 501(c)(3) | 1972 | $42.9 million | $23.5 million | 2025-06 |
| Scbma | Columbia | 501(c)(3) | 1961 | $31.6 million | $52.3 million | 2025-09 |
| Wateree Community Actions Inc | Columbia | 501(c)(3) | 2017 | $30.4 million | $14.1 million | 2024-12 |
| Wesley Commons | Greenwood | 501(c)(3) | 1999 | $30.3 million | $74.7 million | 2025-09 |
| YMCA of Greenville | Greenville | 501(c)(3) | 1937 | $29.8 million | $88.5 million | 2024-12 |
| South Carolina Youth Advocate Program Inc | Columbia | 501(c)(3) | 1991 | $26.6 million | $69.6 million | 2025-12 |
| Upstate Senior Living Inc | Greenville | 501(c)(3) | 2007 | $26.5 million | $136 million | 2024-12 |
| Miracle Hill Ministries Inc | Greenville | 501(c)(3) | 1958 | $26.3 million | $45.8 million | 2025-06 |
| Upper Palmetto YMCA | Rock Hill | 501(c)(3) | 1959 | $23.9 million | $55.7 million | 2025-12 |
| Connie Maxwell Childrens Home | Greenwood | 501(c)(3) | 1934 | $22.6 million | $156 million | 2025-09 |
| Epworth Childrens Home | Columbia | 501(c)(3) | 1950 | $22.1 million | $64.5 million | 2025-12 |
| Project Hope Foundation Inc | Greenville | 501(c)(3) | 1998 | $21.8 million | $19.1 million | 2025-06 |
| Childrens Trust Fund of South Carolina | Columbia | 501(c)(3) | 1985 | $21.3 million | $14.5 million | 2025-09 |
| Berkeley Citizens Inc | Moncks Corner | 501(c)(3) | 1981 | $16.6 million | $16.6 million | 2025-06 |
| Hospice of Laurens County Inc | Clinton | 501(c)(3) | 1987 | $16.5 million | $9.2 million | 2024-12 |
| United Methodist Manor of the Pee Dee | Florence | 501(c)(3) | 1984 | $14.6 million | $33.5 million | 2025-09 |
| Thornwell | Clinton | 501(c)(3) | 1984 | $13.8 million | $67.7 million | 2024-12 |
| Horry Country Disabilities and Special Needs Board | Conway | 501(c)(3) | 1986 | $12.9 million | $13.7 million | 2025-06 |
| Carolina Community Actions Inc | Rock Hill | 501(c)(3) | 1965 | $12.2 million | $3.5 million | 2025-09 |
| Palmetto Dunes Property Owners Association | Hilton Head | 501(c)(4) | 2014 | $11.7 million | $50.2 million | 2024-12 |
| Charleston County Human Services Commission | Charleston | 501(c)(3) | 1986 | $11.6 million | $6.5 million | 2024-12 |
| Senior Solutions | Anderson | 501(c)(3) | 1968 | $11.1 million | $18.7 million | 2025-06 |
| Young Mens Christian Association-Columbia | Lexington | 501(c)(3) | 1943 | $10.4 million | $21.5 million | 2025-12 |
| Clarendon County Disabilities & Special Needs Board | Manning | 501(c)(3) | 1996 | $9.9 million | $9.2 million | 2025-06 |
| Marion-Dillon County Board of Disabilities and Special Needs | Marion | 501(c)(3) | 1989 | $9 million | $6.8 million | 2025-06 |
| Piedmont Community Actions Inc | Spartanburg | 501(c)(3) | 1966 | $8.9 million | $2.4 million | 2025-12 |
| Chester Lancaster Disabilities & Special Needs Board Inc | Lancaster | 501(c)(3) | 1989 | $8.6 million | $4.3 million | 2025-06 |
| Trident Area Agency On Aging Inc | North Charleston | 501(c)(3) | 1992 | $7.6 million | $873,248 | 2025-06 |
| YMCA of Coastal Carolina | Myrtle Beach | 501(c)(3) | 1984 | $7.2 million | $12 million | 2024-12 |
| Darlington County Community Action Agency | Hartsville | 501(c)(3) | 2009 | $7 million | $3.8 million | 2024-12 |
| Second Helpings | Hilton Head | 501(c)(3) | 1992 | $6.9 million | $1.5 million | 2025-12 |
| New Foundations Home for Children Inc | Anderson | 501(c)(3) | 1977 | $6.1 million | $4.1 million | 2025-06 |
| Bamberg County Disabilities & Special Needs Board-Fiscal Agent | Denmark | 501(c)(3) | 1996 | $5.4 million | $6.9 million | 2025-06 |
| Catawba Area Agency On Aging | Rock Hill | 501(c)(3) | 1992 | $5.4 million | $770,006 | 2025-06 |
| East Cooper Community Outreach | Mt Pleasant | 501(c)(3) | 1992 | $5.3 million | $9.5 million | 2025-06 |
| Better Version Opportunity Council | Surfside BCH | 501(c)(3) | 2024 | $5.2 million | $5.2 million | 2025-12 |
| Dream Center of Pickens County | Easley | 501(c)(3) | 2013 | $4.9 million | $2 million | 2025-12 |
| Young Mens Christian Assoc of Anderson South Carolina Inc | Anderson | 501(c)(3) | 1981 | $4.9 million | $25 million | 2024-12 |
| Cooperative Ministry | Columbia | 501(c)(3) | 1988 | $4.7 million | $3.8 million | 2025-06 |
| Growing Home Southeast Inc | Cayce | 501(c)(3) | 2005 | $4.5 million | $3.5 million | 2025-06 |
| Urban League of the Upstate | Belton | 501(c)(3) | 1971 | $4.4 million | $3.3 million | 2025-06 |
| Jubilee Academy Inc | Columbia | 501(c)(3) | 2001 | $4.4 million | $3.9 million | 2024-12 |
| Senior Resources Inc | Columbia | 501(c)(3) | 1967 | $4.3 million | $6.5 million | 2025-06 |
| Landmarks for Families Inc | N Charleston | 501(c)(3) | 1978 | $4.3 million | $5.1 million | 2025-09 |
| Lakelands Region Young Mens Christian Association | Laurens | 501(c)(3) | 1983 | $4.2 million | $11.1 million | 2025-12 |
| Foothills Area YMCA | Seneca | 501(c)(3) | 1992 | $4.2 million | $23.4 million | 2025-12 |
| Young Mens Christian Association of Sumter S C | Sumter | 501(c)(3) | 1943 | $4.1 million | $8.6 million | 2025-12 |
| Mill Community Ministries | Greenville | 501(c)(3) | 2015 | $4 million | $7.6 million | 2025-12 |
| Wings for Kids | Charleston | 501(c)(3) | 1996 | $4 million | $3 million | 2025-06 |
| Kay Phillips Child Advocacy Center | Summerville | 501(c)(3) | 2000 | $3.8 million | $5.5 million | 2024-12 |
| South Carolina Association of Pregnancy Care Centers | Aiken | 501(c)(3) | 2006 | $3.7 million | $3.3 million | 2025-12 |
| Aiken Area Council On Aging Inc | Aiken | 501(c)(3) | 1972 | $3.6 million | $3.8 million | 2025-06 |
| Family Connection of South Carolina Inc | Columbia | 501(c)(3) | 1990 | $3.6 million | $2.7 million | 2025-06 |
| York County Council On Aging Inc | Rock Hill | 501(c)(3) | 1970 | $3.5 million | $2.7 million | 2025-06 |
| Center for Developmental Services D-B-A CDS | Greenville | 501(c)(3) | 1994 | $3.5 million | $3.2 million | 2025-12 |
| Safe Harbor Inc | Greenville | 501(c)(3) | 1995 | $3.4 million | $18.2 million | 2025-09 |
| Pendleton Place Inc | Greenville | 501(c)(3) | 1975 | $3.4 million | $4 million | 2025-06 |
| House of Hope of the Pee Dee | Florence | 501(c)(3) | 1991 | $3.4 million | $5.8 million | 2025-06 |
| Anderson Interfaith Ministries Inc | Anderson | 501(c)(3) | 1991 | $3.3 million | $2.1 million | 2025-06 |
| My Sisters House Inc | N Charleston | 501(c)(3) | 1971 | $3.2 million | $5.1 million | 2025-09 |
| Drayton Hall Preservation Trust | Charleston | 501(c)(3) | 2015 | $3.2 million | $6.3 million | 2025-06 |
| Lutheran Homes of South Carolina Foundation Inc | Irmo | 501(c)(3) | 1942 | $3.2 million | $57.8 million | 2025-09 |
| Christian Services Inc | Lancaster | 501(c)(3) | 2005 | $3 million | $625,277 | 2024-12 |
| Adult Enrichment Centers Inc | Rock Hill | 501(c)(3) | 1986 | $3 million | $3.7 million | 2025-06 |
| Upstate Warrior Solution Inc | Greenville | 501(c)(3) | 2013 | $3 million | $2 million | 2025-09 |
| Bethlehem Center | Spartanburg | 501(c)(3) | 1975 | $2.9 million | $2.9 million | 2024-12 |
| Florence Crittenton Programs of South Carolina Inc | Charleston | 501(c)(3) | 1945 | $2.9 million | $4 million | 2025-06 |
| Hope Inc | Rock Hill | 501(c)(3) | 1983 | $2.8 million | $1 million | 2024-12 |
| Tender Hearts Girls Home Inc | York | 501(c)(3) | 2006 | $2.8 million | $3.1 million | 2025-12 |
| Chosen Children Ministries | Inman | 501(c)(3) | 1996 | $2.7 million | $3.3 million | 2024-12 |
| Trent Hill Center for Children & Families | Hartsville | 501(c)(3) | 2016 | $2.7 million | $2.4 million | 2024-12 |
| Family Preservation Community Services | Columbia | 501(c)(3) | 1999 | $2.6 million | $10.8 million | 2025-06 |
| Project R E S T | Spartanburg | 501(c)(3) | 1984 | $2.6 million | $2.6 million | 2024-12 |
| Dorchester Seniors Inc | Summerville | 501(c)(3) | 1981 | $2.6 million | $4 million | 2025-06 |
| Vital Connections of the Midlands Inc | Columbia | 501(c)(3) | 2004 | $2.5 million | $1.3 million | 2025-06 |
| Newberry County Council On Aging | Newberry | 501(c)(3) | 1970 | $2.5 million | $2.8 million | 2025-06 |
| Kare | Kershaw | 501(c)(3) | 1995 | $2.4 million | $1.5 million | 2025-12 |
| Golden Corner Food Pantry | Seneca | 501(c)(3) | 1986 | $2.4 million | $1.8 million | 2025-12 |
| Edgefield County Public Facilities Corporation | Edgefield | 501(c)(3) | 2025 | $2.4 million | $0 | 2025-06 |
| SVDP Diocesan Council of Charleston | Fountain Inn | 501(c)(3) | 2018 | $2.3 million | $560,587 | 2025-09 |
| North Flint Reinvestment Corporation | Columbia | 501(c)(3) | 2014 | $2.3 million | $1.8 million | 2025-09 |
| Greer Relief & Resources Agency | Greer | 501(c)(3) | 1963 | $2.3 million | $1.2 million | 2025-12 |
| Camp Cole Foundation Inc | Eastover | 501(c)(3) | 2018 | $2.3 million | $23.6 million | 2025-12 |
| Oasis of Hope Inc | Piedmont | 501(c)(3) | 2023 | $2.2 million | $52,364 | 2025-12 |
| Big Red Barn Retreat | Blythewood | 501(c)(3) | 2015 | $2.2 million | $4.1 million | 2025-12 |
| Restoration Project Foundation | Anderson | 501(c)(3) | 2015 | $2.2 million | $20.1 million | 2024-12 |
| Piedmont Agency On Aging Inc | Greenwood | 501(c)(3) | 1971 | $2.2 million | $2.6 million | 2025-06 |
| Childrens Center Inc | Hilton Head | 501(c)(3) | 1968 | $2.1 million | $5.8 million | 2025-12 |
| Serve and Connect | Columbia | 501(c)(3) | 2017 | $2.1 million | $1.2 million | 2025-06 |
| Marlboro County Disabilities and Special Needs Board Inc | Bennettsville | 501(c)(3) | 2004 | $2.1 million | $2.3 million | 2025-06 |
| Senior Action Inc | Greenville | 501(c)(3) | 1968 | $2 million | $7.5 million | 2025-06 |
| The Helping Hands of Clemson Inc | Clemson | 501(c)(3) | 1982 | $2 million | $4.3 million | 2025-06 |
| Freedom House International Inc | Summerville | 501(c)(3) | 2023 | $1.9 million | $728,082 | 2025-12 |
| Jamaica Relief Ministries Inc | Fair Play | 501(c)(3) | 2002 | $1.9 million | $5.8 million | 2025-05 |
| Piedmont Womens Center | Greenville | 501(c)(3) | 1992 | $1.9 million | $6.9 million | 2024-12 |
| Lancaster County Council On Aging Inc | Lancaster | 501(c)(3) | 1976 | $1.9 million | $1.7 million | 2025-06 |
| Greenville Family Partnership | Greenville | 501(c)(3) | 1984 | $1.9 million | $658,930 | 2024-12 |
| Brookland Center for Community Economic Change | West Columbia | 501(c)(3) | 2004 | $1.8 million | $3 million | 2024-12 |
| Memory Matters | Hilton Head | 501(c)(3) | 1998 | $1.8 million | $3.2 million | 2024-12 |
| FPCRC Inc | Columbia | 501(c)(3) | 1988 | $1.8 million | $29.5 million | 2026-04 |
| Pathways Community Center Inc | Rock Hill | 501(c)(3) | 2018 | $1.7 million | $4.9 million | 2024-12 |
| Reconciliation Ministries SC | Columbia | 501(c)(3) | 2004 | $1.7 million | $4.9 million | 2024-12 |
| Carolina Family Services Inc | Greenville | 501(c)(3) | 2007 | $1.7 million | $456,162 | 2024-12 |
| Mission Lexington | Lexington | 501(c)(3) | 2019 | $1.7 million | $2.1 million | 2024-12 |
| Columbia Urban League Inc | Columbia | 501(c)(3) | 1970 | $1.7 million | $3.4 million | 2024-12 |
| East Cooper Home Store Inc | Mt Pleasant | 501(c)(3) | 2004 | $1.6 million | $587,358 | 2026-06 |
| Programs for Exceptional People | Bluffton | 501(c)(3) | 1996 | $1.6 million | $3.2 million | 2025-12 |
| Operation Home Inc | North Charleston | 501(c)(3) | 1999 | $1.6 million | $899,884 | 2024-12 |
| Cliffs Residents Outreach Inc | Travelers RST | 501(c)(3) | 2008 | $1.6 million | $1.3 million | 2025-07 |
| Changed Lives Ministry Inc | Moncks Corner | 501(c)(3) | 2017 | $1.6 million | $3.9 million | 2025-12 |
| James Island Presbyterian Foundation | Charleston | 501(c)(3) | 1985 | $1.6 million | $2.2 million | 2025-06 |
| Southeastern Childrens Home | Duncan | 501(c)(3) | 1970 | $1.6 million | $12.1 million | 2025-12 |
| South Carolina Foster Parent Association | Elgin | 501(c)(3) | 1993 | $1.6 million | $91,016 | 2023-05 |
| Senior Citizens Association in Florence County | Florence | 501(c)(3) | 1969 | $1.6 million | $997,267 | 2025-06 |
| Ronald McDonald House Charities of Columbia SC | Columbia | 501(c)(3) | 1982 | $1.5 million | $5.4 million | 2024-12 |
| McCormick County Senior Center | MC Cormick | 501(c)(3) | 1972 | $1.5 million | $3.3 million | 2025-06 |
| Pilgrims Inn Inc | Rock Hill | 501(c)(3) | 1986 | $1.5 million | $892,194 | 2025-08 |
| Senior Services Inc of Chester County | Chester | 501(c)(3) | 1976 | $1.5 million | $809,604 | 2025-06 |
| Mission Dental South Carolina Inc | Spartanburg | 501(c)(3) | 2021 | $1.5 million | $324,595 | 2025-12 |
| Cumbee Center To Assist Abused Persons | Aiken | 501(c)(3) | 1980 | $1.5 million | $2 million | 2025-12 |
| Coastal District Council of the St Vincent de Paul Society Diocese of | Charleston | 501(c)(3) | 2003 | $1.4 million | $439,322 | 2024-12 |
| Calvary Home for Children | Anderson | 501(c)(3) | 1998 | $1.4 million | $6.1 million | 2024-12 |
| Helping Hands Inc | Aiken | 501(c)(3) | 1973 | $1.4 million | $1.1 million | 2024-12 |
| Greer Community Ministries Inc | Greer | 501(c)(3) | 1973 | $1.3 million | $2 million | 2025-06 |
| Upstate Circle of Friends | Greenville | 501(c)(3) | 2012 | $1.3 million | $1 million | 2024-12 |
| Harvest Christian Ministries Inc | Abbeville | 501(c)(3) | 2016 | $1.3 million | $1.5 million | 2024-12 |
| Lowcountry Orphan Relief | Charleston | 501(c)(3) | 2007 | $1.3 million | $3.9 million | 2025-12 |
| Family Justice Center of Georgetown and Horry Counties | Georgetown | 501(c)(3) | 2007 | $1.3 million | $4.1 million | 2024-12 |
| Edgefield County Senior Citizens Council Inc | Edgefield | 501(c)(3) | 1975 | $1.3 million | $1.8 million | 2025-06 |
| Disability Resource Center | N Charleston | 501(c)(3) | 2001 | $1.3 million | $3.1 million | 2025-09 |
| Help 4 Kids | Myrtle Beach | 501(c)(3) | 2007 | $1.2 million | $529,179 | 2025-12 |
| Darlington County Council On Aging | Darlington | 501(c)(3) | 1979 | $1.2 million | $1.5 million | 2025-06 |
| Helping Hand of Myrtle Beach Inc | Myrtle Beach | 501(c)(3) | 1976 | $1.2 million | $502,977 | 2024-12 |
| New Directions Ofhorry County | Myrtle Beach | 501(c)(3) | 2006 | $1.2 million | $4.1 million | 2025-06 |
| Area Churches Together Serving Acts Inc | Aiken | 501(c)(3) | 1986 | $1.2 million | $1.7 million | 2024-12 |
| Home Works of America Inc | Columbia | 501(c)(3) | 1998 | $1.2 million | $373,870 | 2024-12 |
| Hope in Lancaster Inc | Lancaster | 501(c)(3) | 1983 | $1.2 million | $943,857 | 2024-12 |
| Cherokee County Family Young Mens Christian Association Inc | Gaffney | 501(c)(3) | 1976 | $1.2 million | $4.9 million | 2024-12 |
| Bridge Center Recovery | Anderson | 501(c)(3) | 2018 | $1.1 million | $1.9 million | 2025-12 |
| Young Mens Christian Association of Greater Clinton South Carolina Inc | Clinton | 501(c)(3) | 1973 | $1.1 million | $2.6 million | 2025-12 |
| Newberry County Family YMCA | Newberry | 501(c)(3) | 1985 | $1.1 million | $2.8 million | 2025-12 |
| Flourishing Families of South Carolina | Columbia | 501(c)(3) | 2019 | $1.1 million | $345,660 | 2025-10 |
| Community Initiatives Inc | Greenwood | 501(c)(3) | 2001 | $1.1 million | $531,023 | 2025-12 |
| Megs House | Greenwood | 501(c)(3) | 1990 | $1.1 million | $514,712 | 2024-12 |
| Increasing H O P E | N Charleston | 501(c)(3) | 2006 | $1.1 million | $507,940 | 2025-12 |
| Childrens Recovery Center Inc | Myrtle Beach | 501(c)(3) | 1996 | $1.1 million | $2.6 million | 2025-12 |
| Neighbor To Neighbor of South Carolina Inc | Myrtle Beach | 501(c)(3) | 2006 | $1.1 million | $299,978 | 2025-09 |
| Wexford Plantation Charitable Foundation | Hilton Head | 501(c)(3) | 2012 | $1.1 million | $1.3 million | 2025-12 |
| Fairfield County Council On Aging 321 Bypass | Winnsboro | 501(c)(3) | 2011 | $1.1 million | $1.3 million | 2025-06 |
| Formation Project | N Charleston | 501(c)(3) | 2020 | $1 million | $881,538 | 2024-12 |
| Compassionate Care of Chesterfield | Chesterfield | 501(c)(3) | 1991 | $1 million | $2.5 million | 2025-12 |
| Bethel Mens Shelter | Rock Hill | 501(c)(3) | 2020 | $1 million | $1.2 million | 2025-12 |
| PS I Love You Ministries | Spartanburg | 501(c)(3) | 2017 | $1 million | $698,196 | 2025-12 |
| Cherokee Childrens Home Inc | Gaffney | 501(c)(3) | 1987 | $1 million | $3.9 million | 2025-09 |
| Coastline Womens Center | Myrtle Beach | 501(c)(3) | 2013 | $1 million | $352,519 | 2025-12 |
| Little Smurfs Day Care Center | Andrews | 501(c)(3) | 1984 | $1 million | $774,031 | 2024-12 |
| Alianza Hispana-Hispanic Alliance | Greenville | 501(c)(3) | 2010 | $991,064 | $375,823 | 2024-12 |
| Troy-Johnson Learning Korner Inc | Mullins | 501(c)(3) | 1998 | $984,948 | $477,628 | 2025-06 |
| Defend the Fatherless Inc | Fort Mill | 501(c)(3) | 2019 | $982,894 | $1 million | 2025-12 |
| Partners in Agriculture Inc | Greenville | 501(c)(3) | 2014 | $978,617 | $207,744 | 2025-09 |
| Berkeley Seniors Inc | Moncks Corner | 501(c)(3) | 1996 | $977,455 | $568,532 | 2025-06 |
| Beyond Basic Life Skills | Summerville | 501(c)(3) | 2017 | $968,143 | $655,152 | 2025-12 |
| Helping Hands Ministries of Woodruff Area Inc | Woodruff | 501(c)(3) | 1992 | $966,483 | $413,149 | 2025-12 |
| Missions for the Nations Ministry | Conway | 501(c)(3) | 2014 | $964,284 | $1.4 million | 2025-12 |
| The Lighthouse Ministries | Florence | 501(c)(3) | 1998 | $938,593 | $922,631 | 2025-12 |
| Vital Aging of Williamsburg County Inc | Kingstree | 501(c)(3) | 1997 | $936,259 | $1.7 million | 2025-06 |
| Fostering Great Ideas | Greenville | 501(c)(3) | 2011 | $934,367 | $956,760 | 2024-12 |
| Charleston Recovery Center Inc | Charleston | 501(c)(3) | 2010 | $932,598 | $869,650 | 2025-12 |
| Bread of Life Missions | Hanahan | 501(c)(3) | 2009 | $918,821 | $524,012 | 2025-12 |
| Kennedys Assistive Living & Educational Facility | Columbia | 501(c)(3) | 2009 | $913,500 | $52,206 | 2025-12 |
| Greater Greenwood United Ministry Inc | Greenwood | 501(c)(3) | 1995 | $909,138 | $967,283 | 2025-12 |
| Fosters Child Care & Dev Center Inc | Charleston | 501(c)(3) | 1993 | $908,350 | $3,908 | 2024-12 |
| Megiddo Dream Station | Graniteville | 501(c)(3) | 2012 | $899,142 | $1.5 million | 2025-06 |
| Goforth Recovery | Spartanburg | 501(c)(3) | 2018 | $896,620 | $1.4 million | 2025-12 |
| Jasper County Council for the Aging | Ridgeland | 501(c)(3) | 1975 | $894,220 | $923,297 | 2025-06 |
| Laurens Memorial Home for the Aged Inc | Laurens | 501(c)(3) | 1972 | $884,267 | $334,249 | 2025-06 |
| The Champions Center | Anderson | 501(c)(3) | 2010 | $852,512 | $230,653 | 2025-06 |
| Neighborhood Focus | Greenville | 501(c)(3) | 2006 | $851,746 | $905,662 | 2024-12 |
| Hive Community Circle | Columbia | 501(c)(3) | 2015 | $838,617 | $41,345 | 2025-06 |
| Womens Rights and Empowerment Network | Columbia | 501(c)(3) | 2016 | $828,443 | $2.2 million | 2025-06 |
| Center for Community Services | Simpsonville | 501(c)(3) | 1997 | $828,305 | $738,692 | 2025-12 |
| United Christian Ministries | Easley | 501(c)(3) | 1989 | $815,958 | $361,991 | 2025-12 |
| Neighbors Together Inc | N Charleston | 501(c)(3) | 1992 | $810,797 | $4 million | 2024-12 |
| Radiant Academy | N Charleston | 501(c)(3) | 2022 | $805,169 | $33,998 | 2023-12 |
| Embark Lay Ministries Inc | Hartsville | 501(c)(3) | 2010 | $799,140 | $94,613 | 2025-12 |
| YWCA of Greater Charleston | Charleston | 501(c)(3) | 1971 | $797,303 | $11.7 million | 2025-06 |
| Orangeburg County Council of Aging | Orangeburg | 501(c)(3) | 1974 | $796,206 | $471,570 | 2025-06 |
| Kershaw County Council On Aging Inc | Camden | 501(c)(3) | 1977 | $792,203 | $334,885 | 2025-06 |
| Palmetto Family Council | Columbia | 501(c)(3) | 1993 | $780,223 | $230,753 | 2025-12 |
| Angel Wings Foundation | Moncks Corner | 501(c)(3) | 2017 | $744,909 | $119,677 | 2025-12 |
| Fort Mill Care Center Inc | Fort Mill | 501(c)(3) | 1991 | $728,542 | $910,694 | 2024-12 |
| Dominion Family Services Inc | Spartanburg | 501(c)(3) | 2001 | $718,914 | $636,424 | 2025-06 |
| Florence County Disabilities Foundation | Lake City | 501(c)(3) | 1991 | $715,764 | $1.5 million | 2025-06 |
| Wilderness Way Camp School Inc | Fair Play | 501(c)(3) | 1991 | $705,072 | $2.1 million | 2025-09 |
| A Second Chance Resource Center Network United Inc | N Charleston | 501(c)(3) | 2016 | $704,967 | $765,562 | 2024-12 |
| Greenwood Promise LLC | Greenwood | 501(c)(3) | 2019 | $704,897 | $8.2 million | 2025-06 |
| Outdoor Dream Foundation | Anderson | 501(c)(3) | 2004 | $698,047 | $384,890 | 2023-12 |
| Great Oak Equine Assisted Programs | Aiken | 501(c)(3) | 1996 | $696,710 | $1.3 million | 2025-12 |
| YWCA of the Upper Lowlands Inc | Sumter | 501(c)(3) | 1971 | $695,068 | $626,429 | 2024-12 |
| South Carolina Respite Coalition | Columbia | 501(c)(3) | 2001 | $693,048 | $180,787 | 2026-06 |
| Let There Be Mom Inc | Greenville | 501(c)(3) | 2007 | $670,929 | $1.1 million | 2025-12 |
| Family Promise of the Lowcountry Inc | Bluffton | 501(c)(3) | 2007 | $658,059 | $1.7 million | 2025-12 |
| Prosperity Childcare Inc | Lamar | 501(c)(3) | 2002 | $642,907 | $1.2 million | 2024-12 |
| A Fathers Way | Lancaster | 501(c)(3) | 2000 | $638,034 | $97,030 | 2024-09 |
| Family Promise of the Midlands Inc | Columbia | 501(c)(3) | 2009 | $613,955 | $913,530 | 2024-12 |
| Hampton Transitional Academy | Kingstree | 501(c)(3) | 2021 | $611,878 | $156,306 | 2025-12 |
| Marion County Council On Aging | Marion | 501(c)(3) | 1976 | $606,602 | $297,969 | 2025-06 |
| Union County YMCA | Union | 501(c)(3) | 1988 | $596,883 | $313,402 | 2025-12 |
| Phillis Wheatley Association | Greenville | 501(c)(3) | 1957 | $594,078 | $3.6 million | 2024-12 |
| Fast Forward | Columbia | 501(c)(3) | 2005 | $587,142 | $394,121 | 2026-06 |
| Second Chance Shop | Summerville | 501(c)(3) | 2008 | $584,828 | $435,578 | 2025-12 |
| Pleasant Valley Connection Inc | Greenville | 501(c)(3) | 2002 | $583,772 | $882,715 | 2024-12 |
| Bluffton Community Soup Kitchen | Bluffton | 501(c)(3) | 2018 | $579,896 | $165,169 | 2025-12 |
| Respite Care of Charleston | Charleston | 501(c)(3) | 2011 | $576,222 | $563,825 | 2025-12 |
| Union County Council On Aging | Union | 501(c)(3) | 1974 | $576,026 | $299,215 | 2025-06 |
| Shield Ministries | N Charleston | 501(c)(3) | 2009 | $558,753 | $760,971 | 2025-12 |
| New Beginnings Family Services Inc | Columbia | 501(c)(3) | 2009 | $558,570 | $0 | 2011-06 |
| Neighborhood Outreach Connection | Hilton Head | 501(c)(3) | 2004 | $555,719 | $1.3 million | 2025-07 |
| Jewish Family Services of Greater Charleston | Charleston | 501(c)(3) | 2021 | $551,864 | $686,899 | 2025-12 |
| Senior Centers of Cherokee County Inc | Gaffney | 501(c)(3) | 1976 | $546,585 | $2.6 million | 2025-06 |
| Heavens Treasure | Bluffton | 501(c)(3) | 2022 | $537,405 | $292,517 | 2025-12 |
| Canaan Land Community Center | Marion | 501(c)(3) | 2014 | $535,299 | $1 million | 2025-12 |
| Tara Hall | Georgetown | 501(c)(3) | 1971 | $531,904 | $1.4 million | 2025-09 |
| Bible Way Church of GTN | Georgetown | 501(c)(3) | 1999 | $529,048 | $1.3 million | 2025-12 |
| Hopeful Restoration Group Inc | Little River | 501(c)(3) | 2021 | $522,152 | $981,442 | 2024-12 |
| Nurturing Center Inc | Columbia | 501(c)(3) | 1989 | $516,831 | $502,894 | 2025-06 |
| Jehovah Missionary Baptist Church Christian and Academic School | Sumter | 501(c)(3) | 1990 | $506,609 | $749,901 | 2024-12 |
| Samaritan House | Orangeburg | 501(c)(3) | 2002 | $499,580 | $2.3 million | 2025-12 |
| Progressive Family Life Center Inc | Denmark | 501(c)(3) | 1999 | $495,067 | $621,391 | 2024-12 |
| Benjamin House Ministries Inc | Moore | 501(c)(3) | 2023 | $491,821 | $580,845 | 2025-12 |
| Abc Crisis Pregnancy Center Inc | Florence | 501(c)(3) | 2009 | $488,603 | $1.1 million | 2025-12 |
| Haddis Ministries Incorporated | Easley | 501(c)(3) | 2019 | $485,809 | $77,057 | 2025-12 |
| I Am Voices Inc | Summerville | 501(c)(3) | 2017 | $483,785 | $190,749 | 2025-12 |
| Episcopal Church Home at York Place Inc | West Columbia | 501(c)(3) | 2017 | $465,076 | $5.5 million | 2024-12 |
| SC Hunters and Landowners for the Hungrey | Spartanburg | 501(c)(3) | 2004 | $463,479 | $418,157 | 2024-12 |
| The Coastal Samaritan Counseling Center Inc | Myrtle Beach | 501(c)(3) | 1982 | $460,274 | $59,358 | 2025-12 |
| Lily Pad- A Soft Place To Land Inc | Greer | 501(c)(3) | 2022 | $457,606 | $484,381 | 2025-12 |
| Universal Comunity Improvement Orginization | Irmo | 501(c)(3) | 2021 | $452,668 | $29,354 | 2024-12 |
| W C Christian Academy | Summerville | 501(c)(3) | 2017 | $452,529 | $48,280 | 2022-12 |
| Tri-City Visionaries Inc | Eastover | 501(c)(3) | 2006 | $451,537 | $25,606 | 2025-12 |
| In His Name-Colleton | Walterboro | 501(c)(3) | 2015 | $451,241 | $614,705 | 2025-12 |
| Rcri USA | Abbeville | 501(c)(3) | 2014 | $449,206 | $151,856 | 2025-12 |
| Palmetto Animal Assisted Lifeservices | Columbia | 501(c)(3) | 2007 | $447,733 | $982,143 | 2024-12 |
| Rideability Therapeutic Riding Center Inc | Clover | 501(c)(3) | 2013 | $445,854 | $868,576 | 2025-12 |
| Hope and Health Akot South Sudan | Charleston | 501(c)(3) | 2025 | $442,276 | $55,868 | 2025-12 |
| Economic Opportunity Center Inc | N Charleston | 501(c)(3) | 2020 | $439,499 | $198,304 | 2025-12 |
| Hopewell Senior Day Care Center | Salters | 501(c)(3) | 2009 | $439,451 | $58,952 | 2025-12 |
| Time Served | Greenville | 501(c)(3) | 2024 | $437,583 | $230,572 | 2025-12 |
| Sumter County Developmental Disabilities Foundation | Sumter | 501(c)(3) | 1997 | $437,382 | $1.2 million | 2025-06 |
| Ruths Gleanings | Spartanburg | 501(c)(3) | 2018 | $434,396 | $86,030 | 2025-12 |
| Touched By Als Inc | Greenville | 501(c)(3) | 2022 | $432,489 | $423,815 | 2025-12 |
| Help of Beaufort | Port Royal | 501(c)(3) | 1982 | $427,439 | $1.8 million | 2025-12 |
| Faces and Voices of Recovery Tri-County Inc | Lake Wylie | 501(c)(3) | 2012 | $425,739 | $182,198 | 2025-12 |
| Switch | Greenville | 501(c)(3) | 2014 | $420,743 | $177,045 | 2024-12 |
| All About Change Inc | Greenville | 501(c)(3) | 2014 | $418,135 | $56,670 | 2025-12 |
| Dillon County Council for the Aging Inc | Dillon | 501(c)(3) | 1976 | $414,482 | $747,104 | 2025-06 |
| Upstate-Carolina Adaptive Golf | Greenville | 501(c)(3) | 2019 | $410,028 | $187,305 | 2025-12 |
| Graces Closet | Walhalla | 501(c)(3) | 2016 | $405,969 | $470,718 | 2025-12 |
| Trident Urban League Inc | Charleston | 501(c)(3) | 1992 | $402,789 | $238,451 | 2025-12 |
| Tidelands Community Hospice Foundation | Georgetown | 501(c)(3) | 1983 | $402,719 | $3.7 million | 2024-12 |
| Joes Wish | West Columbia | 501(c)(3) | 2023 | $397,925 | $253,279 | 2024-12 |
| Breaking the Chains International | Hilton Head | 501(c)(3) | 2024 | $391,363 | $5,427 | 2024-12 |
| Peace From Pieces | Greer | 501(c)(3) | 2024 | $390,223 | $46,125 | 2025-12 |
| Servants With A Heart Inc | Clover | 501(c)(3) | 2011 | $387,943 | $156,824 | 2024-12 |
| Patriot Housing Project | Summerville | 501(c)(3) | 2013 | $384,821 | $752,341 | 2024-12 |
| Rebuilding Together Spartanburg Inc | Spartanburg | 501(c)(3) | 1998 | $380,906 | $311,183 | 2025-06 |
| Jazzyz Little Treasurez Childcare & Learning Center | North Augusta | 501(c)(3) | 2016 | $376,707 | $376,707 | 2025-12 |
| Family Promise of York County Inc | Rock Hill | 501(c)(3) | 1999 | $361,765 | $756,516 | 2025-12 |
| Homeless Period Project | Greenville | 501(c)(3) | 2017 | $360,865 | $128,740 | 2025-12 |
| Leo Santa | Greenville | 501(c)(3) | 2022 | $360,687 | $40,288 | 2024-12 |
| Ebenezer Social Action & Community Development Enterprise | Charleston | 501(c)(3) | 2002 | $359,020 | $2 million | 2025-05 |
| Colleton County Council On Aging Inc | Walterboro | 501(c)(3) | 1976 | $358,114 | $762,175 | 2025-06 |
| Winners Travel Foundation Inc | Mayesville | 501(c)(3) | 2019 | $356,510 | $302,853 | 2024-12 |
| Babcock Center Foundation | West Columbia | 501(c)(3) | 1989 | $353,301 | $12.2 million | 2025-06 |
| CL Seven | Columbia | 501(c)(3) | 2015 | $350,049 | $80 | 2025-12 |
| St Christophers Children | Pawleys Island | 501(c)(3) | 2008 | $347,848 | $362,754 | 2025-12 |
| Carolina Childrens Home | Columbia | 501(c)(3) | 1947 | $347,103 | $5.9 million | 2025-09 |
| Edisto Island Yacht Club | Edisto | 501(c)(7) | 2001 | $345,465 | $1.5 million | 2024-12 |
| Hope To Home Furniture Resource | Isle of Palms | 501(c)(3) | 2012 | $341,960 | $286,598 | 2025-12 |
| Hospice House of Greenville | Simpsonville | 501(c)(3) | 2003 | $339,641 | $11.3 million | 2025-12 |
| Plush Meadow Senior Housing Corporation | Spartanburg | 501(c)(3) | 1999 | $338,966 | $848,156 | 2025-12 |
| Bridges for End-Of-Life | Summerville | 501(c)(3) | 1980 | $331,639 | $3 million | 2025-06 |
| Family Promise of Pickens County | Easley | 501(c)(3) | 2012 | $330,591 | $561,028 | 2024-12 |
| Fostering the Family | Anderson | 501(c)(3) | 2018 | $328,890 | $115,081 | 2025-12 |
| Orangeburg Housing Inc | Orangeburg | 501(c)(3) | 1984 | $328,616 | $1.1 million | 2025-06 |
| Greater Waverly Foundation Inc | Columbia | 501(c)(3) | 2004 | $326,025 | $219,000 | 2024-12 |
| Greystar Giving Inc | Charleston | 501(c)(3) | 2010 | $325,210 | $7,116 | 2024-12 |
| Dad Tired | Bluffton | 501(c)(3) | 2017 | $324,373 | $50,239 | 2024-12 |
| Boost | Greenville | 501(c)(3) | 2024 | $322,261 | $108,664 | 2024-12 |
| Jeffrey & Harriet Lampkin Foundation | Sumter | 501(c)(3) | 2025 | $321,749 | $27,562 | 2025-12 |
| Marlboro County Council On Aging | Bennettsville | 501(c)(3) | 1974 | $320,531 | $59,115 | 2025-06 |
| Applewhite Adoptions | Florence | 501(c)(3) | 2015 | $317,771 | $192 | 2024-12 |
| York Electric Trust Inc | York | 501(c)(3) | 1999 | $316,304 | $135,918 | 2025-12 |
| Shepherds Table | Conway | 501(c)(3) | 2007 | $313,270 | $453,306 | 2025-12 |
| Lifebridge of South Carolina | Newberry | 501(c)(3) | 2012 | $312,213 | $246,210 | 2025-12 |
| Good Samaritan Medical Clinic | Chester | 501(c)(3) | 2002 | $311,784 | $420,923 | 2025-12 |
| Bridge 2 Home | Aiken | 501(c)(3) | 2020 | $310,848 | $302,209 | 2025-12 |
| United Ministries of Clinton S C | Clinton | 501(c)(3) | 2003 | $300,149 | $484,598 | 2025-12 |
| All Things Possible Mobility | Fort Mill | 501(c)(3) | 2009 | $297,089 | $271,006 | 2024-12 |
| New Way Global | Greenville | 501(c)(3) | 2021 | $294,229 | $191,363 | 2024-12 |
| Marys Home Care Services Inc | Hemingway | 501(c)(3) | 2007 | $293,746 | $740,706 | 2025-12 |
| Teen Challenge of South Carolina | Georgetown | 501(c)(3) | 2003 | $291,593 | $956,853 | 2025-12 |
| Greater Spartanburg Ministries Incorporated | Spartanburg | 501(c)(3) | 1975 | $289,922 | $522,010 | 2024-12 |
| Next Child Fund Inc | Charleston | 501(c)(3) | 2007 | $289,371 | $4.9 million | 2026-03 |
| Creekside Housing Corporation | Greenville | 501(c)(3) | 2009 | $288,574 | $3.4 million | 2025-09 |
| Greer Community Outreach Center Inc | Greer | 501(c)(3) | 1996 | $286,886 | $5.2 million | 2026-06 |
| Christian Assistance Bridge | Blythewood | 501(c)(3) | 2014 | $286,355 | $287,005 | 2024-12 |
| The Esther Jeanette Shumpert Walker Trust | Columbia | 501(c)(3) | 1987 | $283,601 | $1.6 million | 2025-12 |
| Hope Repair | Moncks Corner | 501(c)(3) | 2021 | $282,974 | $102,192 | 2026-06 |
| The Carnation Foundation Inc | Spartanburg | 501(c)(3) | 2023 | $282,178 | $92,914 | 2025-12 |
| Springbank Christian Center Sister Jeanne Nisley | Kingstree | 501(c)(3) | 2008 | $276,649 | $67,092 | 2025-06 |
| Freedom That Lasts Ministries | Piedmont | 501(c)(3) | 2007 | $275,370 | $67,689 | 2025-12 |
| Life House Community Center | Beaufort | 501(c)(3) | 2020 | $273,202 | $2.6 million | 2025-12 |
| Angel Outreach | Catawba | 501(c)(3) | 2020 | $272,306 | $672,457 | 2025-12 |
| Rotary Club of Camden SC | Camden | 501(c)(4) | 2018 | $271,258 | $432,251 | 2025-06 |
| River Hills Lake Wylie Lions Community Foundation | Lake Wylie | 501(c)(3) | 2008 | $265,458 | $2 million | 2025-06 |
| Horse N Around Therapeutic Riding Center | Lancaster | 501(c)(3) | 2010 | $261,837 | $219,674 | 2024-12 |
| Greenvilles Gift | Greenville | 501(c)(3) | 2016 | $259,719 | $189,520 | 2025-12 |
| Cypress Adventures | Hartsville | 501(c)(3) | 2015 | $258,295 | $392,162 | 2024-12 |
| Have Faith Community Development Corporation | Alcolu | 501(c)(3) | 2003 | $255,391 | $231,233 | 2025-12 |
| Stable Resources | Clover | 501(c)(3) | 2016 | $252,699 | $192,361 | 2025-12 |
| Mission of Hope Ministries | West Columbia | 501(c)(3) | 2003 | $252,693 | $459,498 | 2025-12 |
| Contagious Disciple Making | Greer | 501(c)(3) | 2015 | $250,230 | $113,679 | 2024-12 |
| Caring and Sharing Inc | Hemingway | 501(c)(3) | 1998 | $248,887 | $262,210 | 2025-12 |
| The Open Door Christian Center Inc | Clinton | 501(c)(3) | 1995 | $247,984 | $197,529 | 2024-12 |
| Dream Center Clinic Inc | N Charleston | 501(c)(3) | 2008 | $245,605 | $681,267 | 2025-12 |
| 2R3 Treasure House | Beaufort | 501(c)(3) | 2017 | $245,330 | $200,585 | 2024-12 |
| Barnwell IV Inc | Barnwell | 501(c)(3) | 1982 | $237,410 | $423,841 | 2026-06 |
| Suzerain | Lexington | 501(c)(3) | 2017 | $237,061 | $160,202 | 2025-12 |
| Second Baptist Community Development Corporation | Aiken | 501(c)(3) | 1997 | $236,712 | $1.9 million | 2024-12 |
| Canal Apartments Inc | Bluffton | 501(c)(3) | 1997 | $231,268 | $258,488 | 2025-12 |
| The Ramabai India Project | Mt Pleasant | 501(c)(3) | 2007 | $231,075 | $356,263 | 2024-12 |
| Rembert Area Community Coalition | Rembert | 501(c)(3) | 2003 | $230,605 | $54,401 | 2025-06 |
| Chesco Services | Chesterfield | 501(c)(3) | 1982 | $230,534 | $9.6 million | 2025-06 |
| Mountain View Christian Counseling | Greenville | 501(c)(3) | 2022 | $230,146 | $29,409 | 2025-12 |
| Teachers Supply Closet | Charleston | 501(c)(3) | 2007 | $225,365 | $103,310 | 2025-12 |
| Agape Family Life Center Inc | Hardeeville | 501(c)(3) | 2001 | $224,439 | $243,312 | 2025-12 |
| Ed Childress Memorial Employee Assistance Program | Anderson | 501(c)(3) | 2013 | $219,196 | $88,872 | 2025-12 |
| Gullah Geechee Chamber Foundation Inc | Georgetown | 501(c)(3) | 2020 | $219,151 | $5,265 | 2025-12 |
| Carolina Miracle League Inc | Spartanburg | 501(c)(3) | 2008 | $215,917 | $591,974 | 2025-12 |
| 836 Inc | Myrtle Beach | 501(c)(3) | 2005 | $215,454 | $701,775 | 2025-12 |
| Celso & Maria White Family Foundation | Hilton Head | 501(c)(3) | 2020 | $214,941 | $55,322 | 2025-12 |
| Skyla Strong | Greer | 501(c)(3) | 2017 | $209,475 | $373,999 | 2025-12 |
| Upstate International | Greenville | 501(c)(3) | 1999 | $209,133 | $381,978 | 2024-12 |
| Joint Task Force K9S | Myrtle Beach | 501(c)(3) | 2023 | $208,874 | $242,417 | 2025-12 |
| Fostering Hope Inc | Conway | 501(c)(3) | 2005 | $208,724 | $1.2 million | 2025-06 |
| The Childrens Relief Fund Inc | Hilton Head | 501(c)(3) | 1992 | $208,548 | $267,765 | 2025-12 |
| We3 Missions Inc | Boiling SPGS | 501(c)(3) | 2019 | $208,056 | $422,769 | 2025-12 |
| Hugaroo Inc | Fort Mill | 501(c)(3) | 2007 | $206,199 | $149,824 | 2025-12 |
| Nurses With Purpose Inc | Columbia | 501(c)(3) | 2018 | $205,314 | $5,133 | 2025-12 |
| Sampit Community Organization | Georgetown | 501(c)(3) | 2014 | $204,827 | $0 | 2025-08 |
| Youth and Family Advocacy Services | Mauldin | 501(c)(3) | 2014 | $204,508 | $37,162 | 2024-12 |
| Purple Donkey Human Rescue | Chester | 501(c)(3) | 2024 | $201,015 | $6,281 | 2024-12 |
| Next Chapter Alliance | Rock Hill | 501(c)(3) | 2023 | $199,773 | $51,501 | 2025-12 |
| Trellis Apartments Inc | Florence | 501(c)(3) | 1992 | $199,481 | $531,081 | 2025-06 |
| Hartsville Interfaith Ministries | Hartsville | 501(c)(3) | 1997 | $199,222 | $128,003 | 2025-12 |
| This Is Noteworthy | Charleston | 501(c)(3) | 2015 | $198,881 | $199,016 | 2024-12 |
| Lexington Four Ninety Inc | West Columbia | 501(c)(3) | 1991 | $197,825 | $364,146 | 2025-06 |
| Hartsville Special Housing Inc | Hartsville | 501(c)(3) | 1985 | $197,787 | $376,602 | 2025-06 |
| CFK Inc | Seneca | 501(c)(3) | 2018 | $197,621 | $319,136 | 2025-12 |
| Soul of Palestine | Seneca | 501(c)(3) | 2024 | $195,996 | $16,858 | 2025-08 |
| Law Enforcement Chaplaincy for South Carolina | Columbia | 501(c)(3) | 1998 | $194,936 | $305,381 | 2025-06 |
| Lincoln Tubman Foundation | N Charleston | 501(c)(3) | 2018 | $193,590 | $6.1 million | 2024-12 |
| Missionincubators Inc | Lexington | 501(c)(3) | 2018 | $193,369 | $106,721 | 2025-12 |
| Feed Berkeley SC | Moncks Corner | 501(c)(3) | 2023 | $193,232 | $42,654 | 2025-12 |
| Kingdom Over Culture | West Union | 501(c)(3) | 2020 | $192,820 | $87,400 | 2025-12 |
| Clover Commons Inc | Greenville | 501(c)(3) | 1999 | $192,084 | $741,247 | 2025-06 |
| Crossroads Event Productions Inc | Myrtle Beach | 501(c)(3) | 2017 | $191,623 | $27,127 | 2025-12 |
| Onus Early Learning Center Inc | Kingstree | 501(c)(3) | 2020 | $191,587 | $60,928 | 2024-12 |
| Calhoun County Housing Inc | St Matthews | 501(c)(3) | 1984 | $189,937 | $460,545 | 2025-06 |
| Little Miss Muffet Daycare | Kingstree | 501(c)(3) | 2017 | $189,264 | $36,390 | 2024-12 |
| Canine Angels Inc | Little River | 501(c)(3) | 2011 | $188,945 | $487,353 | 2024-12 |
| Wedgefield Home for Kids | Wedgefield | 501(c)(3) | 2023 | $187,611 | $196,161 | 2025-12 |
| Sandstone Apartments Inc | Columbia | 501(c)(3) | 1996 | $186,486 | $548,160 | 2025-12 |
| Collins Kids the David Bennettfoundation | Conway | 501(c)(3) | 2008 | $186,075 | $93,850 | 2024-12 |
| Emmanuwheel | Lexington | 501(c)(3) | 2011 | $184,449 | $161,147 | 2025-12 |
| Fields To Families | Charleston | 501(c)(3) | 2007 | $183,729 | $127,916 | 2024-12 |
| Birthday Buds Inc | Sullivans Is | 501(c)(3) | 2012 | $183,651 | $35,477 | 2025-12 |
| Just for Today Recovery Center | Taylors | 501(c)(3) | 2025 | $183,561 | $13,637 | 2024-12 |
| Healing Species Inc | Orangeburg | 501(c)(3) | 2010 | $182,651 | $298,306 | 2024-12 |
| Community United Foundation | Chapin | 501(c)(3) | 2014 | $182,585 | $42,233 | 2025-12 |
| Band of Brothers Prison Ministry Inc | Piedmont | 501(c)(3) | 2003 | $182,276 | $80,661 | 2025-12 |
| Lradac Foundation | Columbia | 501(c)(3) | 2012 | $181,585 | $77,014 | 2025-06 |
| Building Blocks Child Development Center Foundation | Aiken | 501(c)(3) | 2004 | $181,275 | $1 | 2013-12 |
| Corban Collective Foundation | Aynor | 501(c)(3) | 2023 | $180,582 | $113,922 | 2025-12 |
| Fyrebird Recovery | Myrtle Beach | 501(c)(3) | 2022 | $180,556 | $109,331 | 2025-12 |
| Good Neighbor Fund | Cayce | 501(c)(3) | 1982 | $179,710 | $318,939 | 2025-06 |
| Orphan Aid Society | N Charleston | 501(c)(3) | 1942 | $179,360 | $804,042 | 2025-12 |
| York County Special Housing Inc | York | 501(c)(3) | 1984 | $179,035 | $347,310 | 2025-06 |
| Horry Shrine Club Inc | Myrtle Beach | 501(c)(3) | 2025 | $178,941 | $49,942 | 2024-12 |
| Lonon Foundation | Mt Pleasant | 501(c)(3) | 2017 | $178,196 | $228,157 | 2025-12 |
| North Augusta Forward | North Augusta | 501(c)(3) | 2002 | $178,156 | $1.6 million | 2024-12 |
| Post Partum Support Charleston | Charleston | 501(c)(3) | 2011 | $177,883 | $52,896 | 2025-06 |
| Fostering Faithfully | Westminster | 501(c)(3) | 2017 | $177,244 | $345,362 | 2025-12 |
| Benjamin E Mays Family Resource Center | Pacolet | 501(c)(3) | 2022 | $175,374 | $2.4 million | 2024-12 |
| Women in Unity | Edgefield | 501(c)(3) | 2005 | $173,044 | $139,380 | 2025-12 |
| Dove Broadcasting Corporation | Taylors | 501(c)(3) | 1974 | $172,504 | $20,362 | 2024-12 |
| Phoebe Pember Foundation | Charleston | 501(c)(3) | 2004 | $172,202 | $133,954 | 2024-12 |
| Chestnut Ferry Court Incorporated | Columbia | 501(c)(3) | 1995 | $171,850 | $723,329 | 2024-12 |
| Life in Abundance | Simpsonville | 501(c)(3) | 2013 | $171,603 | $151,766 | 2025-12 |
| Sunset Village | Greenville | 501(c)(3) | 2007 | $171,423 | $1.6 million | 2025-09 |
| Nicholtown Child and Family Collaborative | Greenville | 501(c)(3) | 2017 | $171,081 | $128,013 | 2025-12 |
| Vanguard Residential Services Inc | Manning | 501(c)(3) | 1984 | $170,007 | $172,217 | 2025-06 |
| C4 Ministries of Laurens County | Laurens | 501(c)(3) | 2017 | $169,677 | $56,805 | 2025-12 |
| Creative Environments Inc | Sumter | 501(c)(3) | 1982 | $169,080 | $625,011 | 2025-06 |
| Cancer Crackdown Inc | Greenville | 501(c)(3) | 2014 | $169,049 | $89,414 | 2024-12 |
| Share Our Suzy Lowcountry | Mt Pleasant | 501(c)(3) | 2016 | $168,366 | $149,592 | 2024-12 |
| Agua Es Vida | Elgin | 501(c)(3) | 2017 | $168,277 | $57,484 | 2025-12 |
| MPD Electric Trust | Florence | 501(c)(3) | 2026 | $168,025 | $373,961 | 2024-12 |
| 9-11 Never Forget Golf | Myrtle Beach | 501(c)(3) | 2024 | $167,830 | $1,320 | 2025-12 |
| Family Resource Center for Disabili Disabilities and Special Needs Inc | Charleston | 501(c)(3) | 2001 | $167,724 | $4,050 | 2024-12 |
| Project Josiah Restoration Ministry | Sumter | 501(c)(3) | 2014 | $166,547 | $56,377 | 2024-12 |
| Embrace the Dream Foundation Inc | Greenville | 501(c)(3) | 2013 | $166,157 | $89,431 | 2025-12 |
| Hospice Care Charity Inc | Lexington | 501(c)(3) | 2004 | $165,716 | $512,184 | 2024-12 |
| Amateur Athletic Union of the United States in | Irmo | 501(c)(3) | 2024 | $165,160 | $47,466 | 2025-07 |
| Happy Homes Inc | Summerville | 501(c)(3) | 1984 | $164,413 | $363,697 | 2025-06 |
| Litchfield Beautification Foundation | Pawleys Isl | 501(c)(3) | 2014 | $161,287 | $356,669 | 2024-12 |
| Laurens County Specialty Housing Corporation | Laurens | 501(c)(3) | 1987 | $160,926 | $164,432 | 2025-06 |
| Hub Transition Centers | Greenwood | 501(c)(3) | 2023 | $159,002 | $23,611 | 2025-06 |
| Staying Connected | Bluffton | 501(c)(3) | 2014 | $156,133 | $482,543 | 2025-12 |
| Lowcountry Gullah Foundation | Hilton Head | 501(c)(3) | 2021 | $155,914 | $119,240 | 2025-12 |
| Project Okurase | N Charleston | 501(c)(3) | 2014 | $155,904 | $47,459 | 2025-12 |
| Four Rivers Outreach Community Development Corporation | N Charleston | 501(c)(3) | 2012 | $155,405 | $64,370 | 2025-12 |
| Lowcountry Alliance for Modelcommunities | N Charleston | 501(c)(3) | 2016 | $155,380 | $408,831 | 2024-12 |
| Fortitude Foundation Inc | Columbia | 501(c)(3) | 2011 | $154,517 | $1 | 2025-06 |
| Next Mission Inc | Hollywood | 501(c)(3) | 2024 | $154,400 | $78,732 | 2025-12 |
| South Carolina Childrens Hospital Collaborative | Mount Pleasant | 501(c)(4) | 2002 | $153,993 | $276,537 | 2025-12 |
| Lowcountry Dress for Success | Bluffton | 501(c)(3) | 2015 | $151,411 | $199,029 | 2024-12 |
| Mindful Lending | North Charleston | 501(c)(3) | 2025 | $151,411 | $773,569 | 2025-12 |
| United Way of Chester County Inc | Chester | 501(c)(3) | 2025 | $150,087 | $328,586 | 2024-12 |
| Asian American Store Ownrers Association of South Carolina Inc | Orangeburg | 501(c)(3) | 2020 | $149,488 | $98,792 | 2025-12 |
| Champions of Change Inc | Fort Mill | 501(c)(3) | 2016 | $148,828 | $49,154 | 2025-12 |
| Transformative Organizational Consulting | N Charleston | 501(c)(3) | 2024 | $147,667 | $61,552 | 2025-12 |
| Broughton West Inc | Orangeburg | 501(c)(3) | 1992 | $147,092 | $320,365 | 2025-06 |
| Gifting Tree Foundation Inc | Aiken | 501(c)(3) | 2020 | $143,361 | $143,598 | 2025-12 |
| Helping Hand Center Inc | Pineland | 501(c)(3) | 2013 | $143,303 | $30,689 | 2025-12 |
| Adaptive Pickleball | Greer | 501(c)(3) | 2022 | $143,281 | $49,997 | 2025-12 |
| Four Holes Indian Organization Edisto Tribal Inc | Ridgeville | 501(c)(3) | 1977 | $142,902 | $1.1 million | 2025-12 |
| Trustees Education Network Inc | Columbia | 501(c)(3) | 1999 | $142,615 | $154,426 | 2025-09 |
| Proactive Parenting Initiative | Travelers RST | 501(c)(3) | 2015 | $141,896 | $62,135 | 2025-12 |
| Sonshine Club | Spartanburg | 501(c)(3) | 2011 | $140,899 | $151,881 | 2025-12 |
| Tri-Development Center Foundation | Aiken | 501(c)(3) | 2000 | $140,700 | $569,969 | 2025-06 |
| Wigs for Cancer Inc | Little River | 501(c)(3) | 2014 | $139,883 | $96,921 | 2025-12 |
| Lake Wylie & Clover Mayday Project | Lake Wylie | 501(c)(3) | 2012 | $138,498 | $230,474 | 2024-12 |
| Disabilities Foundation of Charleston County Inc | N Charleston | 501(c)(3) | 1992 | $137,585 | $4.6 million | 2025-06 |
| In His Image Outreach Inc | Belton | 501(c)(3) | 2018 | $136,891 | $3,658 | 2025-05 |
| Thompson Children Learning Center Inc | Hartsville | 501(c)(3) | 2008 | $136,426 | $95,861 | 2024-12 |
| Judson Community Partnership | Greenville | 501(c)(3) | 2015 | $136,115 | $122,111 | 2025-12 |
| Community Alternatives Inc | York | 501(c)(3) | 1995 | $136,068 | $273,232 | 2025-06 |
| Heart of Compassion | Belton | 501(c)(3) | 2020 | $135,734 | $160,437 | 2025-12 |
| Youth Empowerment Services Inc | Charleston | 501(c)(3) | 2000 | $134,360 | $36,551 | 2024-12 |
| Grace Impact Development Center Inc | Moncks Corner | 501(c)(3) | 2017 | $133,614 | $139,309 | 2024-12 |
| Holly Ridge Apartments Inc | Fort Mill | 501(c)(3) | 2003 | $130,949 | $564,828 | 2025-09 |
| Christmas Shoes | Greer | 501(c)(3) | 2014 | $130,207 | $68,145 | 2025-12 |
| Sheltered | Lancaster | 501(c)(3) | 2021 | $129,027 | $225,208 | 2024-12 |
| Three Rivers Respite | Johns Island | 501(c)(3) | 2018 | $128,093 | $329,431 | 2024-12 |
| Speak Up Magazine Inc | Rock Hill | 501(c)(3) | 2011 | $128,015 | $509 | 2025-06 |
| Foster Care Clothing Closet Inc | Florence | 501(c)(3) | 2016 | $127,618 | $385,600 | 2025-12 |
| Umoja Village | Aiken | 501(c)(3) | 2021 | $126,881 | $100,921 | 2025-12 |
| Andersons Emergency Kitchen Inc | Anderson | 501(c)(3) | 1985 | $126,652 | $622,015 | 2025-12 |
| Simple Ministries of Asia | Irmo | 501(c)(3) | 2014 | $126,513 | $8 | 2023-12 |
| Megan Schulman Memorial Foundation | Myrtle Beach | 501(c)(3) | 2021 | $125,362 | $176,546 | 2024-12 |
| Laurelwood Inc of Spartanburg | Boiling Springs | 501(c)(3) | 1996 | $125,143 | $418,355 | 2025-06 |
| Magdalene House of Charleston | Ladson | 501(c)(3) | 2007 | $124,900 | $188,120 | 2024-12 |
| Win Today Foundation | Seneca | 501(c)(3) | 2023 | $124,777 | $157,679 | 2025-12 |
| Love and Grace Ministries - Haiti | Bluffton | 501(c)(3) | 2011 | $124,624 | $71,083 | 2024-12 |
| Global Hope Project | Fort Mill | 501(c)(3) | 2014 | $124,335 | $69,815 | 2024-12 |
| Strides of Strength Therapeutic Services Inc | Chester | 501(c)(3) | 2018 | $122,640 | $211,755 | 2025-06 |
| Ayres Housing Inc | Greenville | 501(c)(3) | 1993 | $122,619 | $377,977 | 2025-06 |
| New Hope II of Florence Inc | Florence | 501(c)(3) | 1997 | $120,772 | $361,187 | 2025-12 |
| Peninsula Biblical Counseling Ministries | Charleston | 501(c)(3) | 2015 | $120,562 | $120,899 | 2025-12 |
| Fairfield Electric Trust Inc | Blythewood | 501(c)(3) | 1994 | $120,343 | $272,875 | 2025-12 |
| McCormick Helping Hands United Inc | MC Cormick | 501(c)(3) | 1999 | $119,506 | $395,037 | 2025-12 |
| Second Chance Bikes | Charleston | 501(c)(3) | 2018 | $119,501 | $67,475 | 2024-12 |
| A Home for Me Ministries Inc | Simpsonville | 501(c)(3) | 2015 | $119,119 | $127,669 | 2025-12 |
| TC Chillemi Foundation Inc | Hilton Head | 501(c)(3) | 2020 | $118,992 | $35,283 | 2025-12 |
| Waymaker Off-Road Wheelchairs Inc | Lamar | 501(c)(3) | 2022 | $118,827 | $141,936 | 2025-12 |
| JTD Homes Inc | Orangeburg | 501(c)(3) | 1994 | $117,418 | $387,780 | 2025-06 |
| Marys House Ministry Alliance for Regaining Your Safety | Pickens | 501(c)(3) | 2004 | $116,512 | $248,964 | 2025-12 |
| Refugee Hope Upstate Inc | Salem | 501(c)(3) | 2023 | $116,128 | $58,954 | 2025-12 |
| Ems Closet | Columbia | 501(c)(3) | 2022 | $116,122 | $82,054 | 2024-12 |
| Second Look Charities | Camden | 501(c)(3) | 2013 | $116,058 | $179,571 | 2025-12 |
| New Beginning Christian Outreach Ministries | Florence | 501(c)(3) | 2020 | $115,920 | $230,730 | 2025-12 |
| Earth & Star Spiritual Wellness Cente | Florence | 501(c)(3) | 2023 | $115,716 | $27,636 | 2025-12 |
| Selah Grey Foundation | Greenville | 501(c)(3) | 2025 | $115,311 | $13,719 | 2025-12 |
| Think Liberia Incorporated | Orangeburg | 501(c)(3) | 2015 | $114,433 | $13,003 | 2025-12 |
| Wildfire Foundation | Mt Pleasant | 501(c)(3) | 2023 | $114,000 | $70,008 | 2024-12 |
| Kings and Queens International | Lancaster | 501(c)(3) | 2015 | $112,705 | $100,255 | 2025-12 |
| Community Cafe | Clover | 501(c)(3) | 2011 | $112,553 | $42,519 | 2025-12 |
| Women of Woodside Inc | Aiken | 501(c)(4) | 2010 | $111,857 | $7,575 | 2025-06 |
| Holy City Missions | N Charleston | 501(c)(3) | 2021 | $111,209 | $399,507 | 2025-12 |
| Omega Men of Columbia South Carolina Inc | Columbia | 501(c)(3) | 2012 | $109,329 | $100,803 | 2023-10 |
| Lake Bowen Church Child Development Center | Inman | 501(c)(3) | 2004 | $108,787 | $138,734 | 2025-07 |
| International Society for Ecological Economics | Travelers RST | 501(c)(3) | 1991 | $108,533 | $155,150 | 2025-12 |
| Royal Foundation | N Charleston | 501(c)(3) | 2008 | $108,136 | $108,519 | 2025-12 |
| Described and Captioned Media Program | Spartanburg | 501(c)(3) | 2024 | $107,319 | $90,204 | 2025-12 |
Every nonprofit in South Carolina
Read from the IRS Exempt Organizations Business Master File, updated by the IRS on October 24, 2026 and rebuilt here every morning. Revenue and assets are from each organization's latest filing as the IRS lists it; the IRS record is the official one. Organizations only: no people are named on these pages.