Data / Nonprofits / South Carolina / Health care
Health care nonprofits in South Carolina: 595 registered with the IRS
595 health care nonprofits are registered with the IRS in South Carolina, 588 of them 501(c)(3) charities; the 263 that report revenue took in $17.82 billion. The most are in Columbia (63), Greenville (44), Charleston (42). The largest by revenue: Prisma Health - Upstate ($3.61 billion), Prisma Health-Midlands ($2.08 billion), Lexington Health Inc ($1.77 billion).
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The 500 largest by revenue
| Organization | City | Type | Since | Revenue | Assets | Filing |
|---|---|---|---|---|---|---|
| Prisma Health - Upstate | Greenville | 501(c)(3) | 2016 | $3.61 billion | $1.41 billion | 2025-09 |
| Prisma Health-Midlands | Greenville | 501(c)(3) | 1997 | $2.08 billion | $1.06 billion | 2025-09 |
| Lexington Health Inc | West Columbia | 501(c)(3) | 2020 | $1.77 billion | $2.30 billion | 2025-09 |
| McLeod Regional Medical Center of the Pee Dee Inc | Florence | 501(c)(3) | 1975 | $1.49 billion | $3.03 billion | 2025-09 |
| Prisma Health-University Medical Group | Greenville | 501(c)(3) | 1998 | $925.8 million | $132.7 million | 2025-09 |
| Anmed Health | Anderson | 501(c)(3) | 1937 | $854.6 million | $1.54 billion | 2024-12 |
| Bon Secours-St Francis Xavier Hospital Inc | Charleston | 501(c)(3) | 1998 | $620.6 million | $319 million | 2024-12 |
| Roper Hospital Inc | Charleston | 501(c)(3) | 1955 | $539.5 million | $343.1 million | 2024-12 |
| McLeod Loris Seacoast Hospital | Florence | 501(c)(3) | 2013 | $466.9 million | $486.4 million | 2025-09 |
| Conway Hospital Inc | Conway | 501(c)(3) | 1955 | $416.5 million | $864.7 million | 2025-09 |
| McLeod Health | Florence | 501(c)(3) | 2003 | $399.6 million | $192.2 million | 2025-09 |
| Prisma Health | Greenville | 501(c)(3) | 2017 | $339.5 million | $4.64 billion | 2025-09 |
| Georgetown Memorial Hospital | Georgetown | 501(c)(3) | 1959 | $268.1 million | $63 million | 2025-09 |
| Georgetown Hospital System | Georgetown | 501(c)(3) | 2003 | $265.8 million | $585.1 million | 2025-09 |
| Roper St Francis Healthcare | Ladson | 501(c)(3) | 1998 | $259.4 million | $2.44 billion | 2024-12 |
| Prisma Health - Blount Memorial Hospital Inc | Greenville | 501(c)(3) | 2025 | $240.5 million | $166.6 million | 2025-09 |
| Greenville Health Corporation | Greenville | 501(c)(3) | 1999 | $230.3 million | $66.7 million | 2025-09 |
| Waccamaw Community Hospital | Georgetown | 501(c)(3) | 2003 | $225.7 million | $295.6 million | 2025-09 |
| Roper Saint Francis Physicians Network | Ladson | 501(c)(3) | 2009 | $213 million | $94.4 million | 2024-12 |
| McLeod Physician Associates II | Florence | 501(c)(3) | 2006 | $210.1 million | $47.2 million | 2025-09 |
| Hopehealth Inc | Florence | 501(c)(3) | 1995 | $200.5 million | $141.3 million | 2024-12 |
| Bon Secours Medical Group Greenville Specialty Care LLC | Greenville | 501(c)(3) | 2023 | $155.6 million | $24.4 million | 2024-12 |
| Roper St Francis Hospital-Berkeley Inc | Summerville | 501(c)(3) | 2012 | $152.1 million | $281.9 million | 2024-12 |
| The Blood Connection Incorporated | Piedmont | 501(c)(3) | 1978 | $149.7 million | $107.7 million | 2025-08 |
| Roper St Francis Mount Pleasant Hospital | Mt Pleasant | 501(c)(3) | 1936 | $139.7 million | $86.6 million | 2024-12 |
| McLeod Health Clarendon | Florence | 501(c)(3) | 2016 | $102.5 million | $49.7 million | 2025-09 |
| Welvista | Columbia | 501(c)(3) | 1998 | $96 million | $48.7 million | 2025-06 |
| McLeod Medical Center Dillon | Florence | 501(c)(3) | 2003 | $87.6 million | $152.5 million | 2025-09 |
| Caresouth Carolina Inc | Hartsville | 501(c)(3) | 1980 | $86.2 million | $48.5 million | 2025-05 |
| McLeod Health Cheraw | Florence | 501(c)(3) | 2015 | $84.5 million | $40.8 million | 2025-09 |
| Genesis Healthcare Inc | Columbia | 501(c)(3) | 2010 | $76.3 million | $166.8 million | 2025-06 |
| Little River Medical Center Inc | Little River | 501(c)(3) | 1980 | $49.7 million | $34.4 million | 2025-05 |
| Musc Health Partners | Charleston | 501(c)(3) | 2020 | $49.4 million | $9.1 million | 2025-06 |
| South Carolina Episcopal Home at Still Hopes | West Columbia | 501(c)(3) | 1978 | $48.1 million | $201.2 million | 2025-09 |
| Hampton Regional Medical Center | Varnville | 501(c)(3) | 1996 | $40.9 million | $67.6 million | 2025-09 |
| Carolina Health Centers Inc | Greenwood | 501(c)(3) | 1978 | $40.1 million | $26.5 million | 2025-05 |
| Regenesis Organization Community Health Center | Spartanburg | 501(c)(3) | 2001 | $38.5 million | $17.5 million | 2025-06 |
| St Francis Physician Services Inc | Greenville | 501(c)(3) | 2006 | $36.9 million | $123.7 million | 2024-12 |
| The Charles Lea Center Inc | Spartanburg | 501(c)(3) | 1968 | $36.6 million | $14.9 million | 2024-06 |
| Lexmed Inc | Lexington | 501(c)(3) | 2021 | $36.2 million | $23.8 million | 2025-09 |
| Anmed Health Cannon | Pickens | 501(c)(3) | 1957 | $36 million | $27.3 million | 2024-12 |
| Sandhills Medical Foundation Inc | Jefferson | 501(c)(3) | 1980 | $35.1 million | $27.5 million | 2025-05 |
| Tandem Health SC | Sumter | 501(c)(3) | 2000 | $34.5 million | $21.1 million | 2025-09 |
| Beaufort-Jasper-Hampton Comprehensive Health Services Inc | Ridgeland | 501(c)(3) | 1971 | $33.2 million | $28.2 million | 2024-05 |
| Low Country Health Care System | Fairfax | 501(c)(3) | 1999 | $32.3 million | $22.7 million | 2025-11 |
| New Horizon Family Health Services Inc | Greenville | 501(c)(3) | 1991 | $31.3 million | $23.3 million | 2025-01 |
| Self Regional Healthcare Partners | Greenwood | 501(c)(3) | 2018 | $25.6 million | $7.9 million | 2025-09 |
| Health Care Partners of South Carolina Inc | Conway | 501(c)(3) | 1981 | $25.5 million | $24.4 million | 2026-03 |
| Kershawhealth | Camden | 501(c)(3) | 1990 | $24.7 million | $113.8 million | 2025-09 |
| Musc Health | Charleston | 501(c)(3) | 2017 | $24.6 million | $119.9 million | 2025-06 |
| Careteam Plus Inc | Conway | 501(c)(3) | 1995 | $22.5 million | $13.7 million | 2025-03 |
| St Lukes Free Medical Clinic of Spartanburg Inc | Spartanburg | 501(c)(3) | 1992 | $21.3 million | $5.5 million | 2025-12 |
| Medical Society of S C | Charleston | 501(c)(3) | 1979 | $17.7 million | $701.6 million | 2024-12 |
| McLeod Medical Center Foundation | Florence | 501(c)(3) | 1988 | $16.5 million | $36.4 million | 2025-09 |
| Roper St Francis Foundation | Ladson | 501(c)(3) | 1987 | $16.5 million | $48.4 million | 2024-12 |
| Blount Memorial Physician Group Inc | Greenville | 501(c)(3) | 2026 | $15.6 million | $20.1 million | 2025-09 |
| Mainsail Health Partners | Charleston | 501(c)(3) | 2020 | $15.1 million | $207.1 million | 2025-06 |
| Westminster Presbyterian Center Inc | Rock Hill | 501(c)(3) | 1984 | $14.5 million | $38.5 million | 2024-12 |
| The Spartanburg Regional Healthcare System Foundation | Spartanburg | 501(c)(3) | 1991 | $13.1 million | $67.4 million | 2025-09 |
| Ronald McDonald House Charleston | Charleston | 501(c)(3) | 1982 | $12.1 million | $33.4 million | 2025-12 |
| Prisma Health Midlands Foundation | Columbia | 501(c)(3) | 1982 | $11.7 million | $61.6 million | 2025-09 |
| Tuomey Foundation | Sumter | 501(c)(3) | 1996 | $10.4 million | $37.2 million | 2025-09 |
| Foothills Community Health Care | Anderson | 501(c)(3) | 2008 | $10 million | $13 million | 2026-04 |
| South Carolina State Office of Rural Health Inc | Lexington | 501(c)(3) | 1996 | $9.6 million | $7.7 million | 2025-06 |
| Marion County Healthcare Foundation | Mullins | 501(c)(4) | 2013 | $8.9 million | $88.7 million | 2025-12 |
| Beaufort Memorial Hospital Endowment Foundation | Beaufort | 501(c)(3) | 1985 | $7.5 million | $31.8 million | 2025-09 |
| Primary Care Association of SC Inc | Columbia | 501(c)(3) | 1986 | $6.5 million | $4.8 million | 2025-03 |
| Upper Savannah Care Services | Greenwood | 501(c)(3) | 1996 | $6.5 million | $3.4 million | 2025-03 |
| Self Memorial Regional Health Services Inc | Greenwood | 501(c)(3) | 1988 | $5.4 million | $10.8 million | 2025-09 |
| Community Medical Clinic of Kershaw County | Camden | 501(c)(3) | 1999 | $5.3 million | $1.4 million | 2024-12 |
| Conway Hospital Emergency Professional Services | Conway | 501(c)(3) | 2010 | $5.3 million | $1.3 million | 2025-09 |
| Make-A-Wish Foundation of SC Inc | Greenville | 501(c)(3) | 1985 | $5.1 million | $4.3 million | 2025-08 |
| STC Healthcare Partners Risk Retention Group | Charleston | 501(c)(3) | 2022 | $4.7 million | $24 million | 2025-12 |
| South of Broad Healthcare | Beaufort | 501(c)(3) | 2019 | $4.2 million | $129.3 million | 2025-09 |
| Roper St Francis Ancillary Services | Ladson | 501(c)(3) | 2023 | $4 million | $1.3 million | 2024-12 |
| Oconee Memorial Hospital Foundation Inc | Seneca | 501(c)(3) | 2002 | $3.7 million | $18.5 million | 2025-09 |
| Piedmont Care Inc | Spartanburg | 501(c)(3) | 1996 | $3.6 million | $3.3 million | 2025-03 |
| Pee Dee Healthy Start Inc | Florence | 501(c)(3) | 1997 | $3.6 million | $585,568 | 2025-09 |
| Anderson Free Clinic Inc | Anderson | 501(c)(3) | 1986 | $3.6 million | $1.5 million | 2024-12 |
| Williamsburg Regional Hospital | Kingstree | 501(c)(3) | 2002 | $3.5 million | $4.2 million | 2025-09 |
| Friendship Medical Clinic Inc | Conway | 501(c)(3) | 2003 | $3.4 million | $296,866 | 2025-12 |
| Palmetto Care Connections | Bamberg | 501(c)(3) | 2014 | $3.3 million | $5.3 million | 2025-12 |
| Anmed Health Foundation | Anderson | 501(c)(3) | 2014 | $3.1 million | $8.8 million | 2024-12 |
| Health Sciences South Carolina | Columbia | 501(c)(3) | 2021 | $3 million | $2.6 million | 2025-06 |
| York County Disabilities Foundation | York | 501(c)(3) | 2000 | $3 million | $11.3 million | 2025-06 |
| Oconee Medical Holding | Seneca | 501(c)(3) | 1956 | $2.6 million | $39.9 million | 2025-09 |
| Chester Healthcare Foundation | Chester | 501(c)(4) | 2006 | $2.6 million | $19.2 million | 2025-12 |
| Mercy Medicine Clinic | Florence | 501(c)(3) | 2000 | $2.5 million | $1.6 million | 2025-12 |
| A&T Care | Kershaw | 501(c)(3) | 2017 | $2.5 million | $45,772 | 2024-12 |
| Barrier Islands Free Medical Clinic Inc | Johns Island | 501(c)(3) | 2006 | $2.4 million | $11.5 million | 2025-12 |
| Bluffton Jasper County Volunteers in Medicine | Bluffton | 501(c)(3) | 2010 | $2.4 million | $2.2 million | 2025-12 |
| United Housing Associates Inc | Columbia | 501(c)(3) | 1994 | $2.1 million | $10.7 million | 2025-12 |
| Allied Services Risk Retention Group | Charleston | 501(c)(3) | 2005 | $2 million | $8 million | 2024-12 |
| Good Shepherd Free Medical Clinic of Laurens County | Clinton | 501(c)(3) | 1994 | $1.9 million | $529,504 | 2024-12 |
| Unity Health On Main | Greenville | 501(c)(3) | 2016 | $1.9 million | $634,423 | 2024-12 |
| Conway Hospital Community Services | Conway | 501(c)(3) | 2002 | $1.8 million | $6.8 million | 2025-09 |
| Five Points Foundation Inc | Columbia | 501(c)(3) | 2012 | $1.8 million | $968,299 | 2025-06 |
| Joseph H Neal Health Collaborative | Cayce | 501(c)(3) | 2018 | $1.8 million | $1.2 million | 2025-06 |
| Lowcountry Pregnancy Center | North Charleston | 501(c)(3) | 1988 | $1.8 million | $3.4 million | 2025-12 |
| Goldencare Inc | Lancaster | 501(c)(3) | 2002 | $1.8 million | $2.6 million | 2024-12 |
| Medserve | Columbia | 501(c)(3) | 2016 | $1.7 million | $1.5 million | 2024-12 |
| Allendale County Rescue Squad Inc | Allendale | 501(c)(3) | 1998 | $1.6 million | $70,760 | 2025-06 |
| Pregnancy Center and Clinic of Low Country Inc | Hilton Head | 501(c)(3) | 1991 | $1.6 million | $2.9 million | 2025-12 |
| Smokefree SC | Columbia | 501(c)(3) | 2002 | $1.6 million | $1.2 million | 2025-06 |
| Columbia Free Medical Clinic | Columbia | 501(c)(3) | 1985 | $1.5 million | $1.8 million | 2025-12 |
| Lowcountry Area Health Education Center | Walterboro | 501(c)(3) | 2001 | $1.5 million | $4.7 million | 2025-06 |
| Upstate Area Health Education Center | Greenville | 501(c)(3) | 1978 | $1.3 million | $2.4 million | 2025-06 |
| Conway Hospital Foundation Inc | Conway | 501(c)(3) | 1989 | $1.2 million | $10.3 million | 2025-09 |
| Cancer Survivors Park Alliance | Greenville | 501(c)(3) | 2000 | $1.2 million | $899,052 | 2025-06 |
| Accesshealth Horry Inc | Conway | 501(c)(3) | 2004 | $1.1 million | $1 million | 2024-12 |
| Palmetto Promise Institute | Columbia | 501(c)(3) | 2009 | $1.1 million | $1.3 million | 2025-12 |
| Coastal Plains Physician Associates | Varnville | 501(c)(3) | 2005 | $1.1 million | $1.9 million | 2025-09 |
| Hospice Care Foundation of the Piedmont Inc | Greenwood | 501(c)(3) | 2019 | $1.1 million | $5.4 million | 2025-09 |
| Carolina Pregnancy Center | Spartanburg | 501(c)(3) | 1985 | $1 million | $2.9 million | 2024-12 |
| Palmetto Womens Center | Rock Hill | 501(c)(3) | 1985 | $955,084 | $955,348 | 2025-08 |
| South Carolina Institute of Medicine and Public Health | Columbia | 501(c)(3) | 2012 | $895,902 | $229,040 | 2025-06 |
| Charleston Area Therapeutic Riding Inc | Johns Island | 501(c)(3) | 1992 | $893,094 | $2.2 million | 2025-06 |
| Good Neighbor Free Medical Clinic | Beaufort | 501(c)(3) | 2007 | $875,572 | $1 million | 2024-12 |
| Foothills Care Center Inc | Seneca | 501(c)(3) | 1993 | $823,544 | $936,911 | 2025-12 |
| Prisma Health Baptist Easley Foundation | Easley | 501(c)(3) | 1989 | $800,906 | $8.6 million | 2025-09 |
| River Hills Emergency Squad Incc | Clover | 501(c)(3) | 1979 | $755,178 | $238,879 | 2024-12 |
| Swing for the Lowcountry LLC | Daniel Island | 501(c)(3) | 2023 | $746,320 | $420,960 | 2025-12 |
| Taylors Free Medical Clinic Inc | Taylors | 501(c)(3) | 2005 | $697,622 | $759,228 | 2024-12 |
| Healthy Smiles of Spartanburg Inc | Spartanburg | 501(c)(3) | 2004 | $665,788 | $1.5 million | 2025-06 |
| Medicinal Whiskey Charity Inc | Greenville | 501(c)(3) | 2021 | $659,747 | $145,552 | 2024-12 |
| Scoa Cares Inc | Columbia | 501(c)(3) | 2006 | $651,880 | $6.6 million | 2025-12 |
| Wild Hearts Equine Therapeutic Center Inc | Seneca | 501(c)(3) | 2016 | $637,797 | $840,755 | 2025-06 |
| South Carolina Free Clinic Association | Union | 501(c)(3) | 2007 | $631,540 | $632,832 | 2025-12 |
| South Carolina Health Information Partners | Columbia | 501(c)(3) | 2015 | $603,935 | $853,359 | 2025-06 |
| Lavie Pregnancy Care Center | Lexington | 501(c)(3) | 2019 | $601,201 | $792,828 | 2025-12 |
| Brain Injury Association of South Carolina | Columbia | 501(c)(3) | 2001 | $574,057 | $555,881 | 2025-06 |
| Carefirst Carolina Foundation Inc | Hartsville | 501(c)(3) | 2004 | $563,245 | $569,299 | 2025-05 |
| Johnsonville Rescue Squad and Ambulance Service | Johnsonville | 501(c)(3) | 1988 | $530,819 | $79,427 | 2025-06 |
| The Palmetto Palace | Charleston | 501(c)(3) | 2007 | $510,577 | $30,877 | 2025-12 |
| Baptist Healthcare System of South Carolina Inc | Columbia | 501(c)(3) | 1946 | $505,234 | $825,948 | 2025-09 |
| Hold Out the Lifeline A Mission To Families Inc | Columbia | 501(c)(3) | 2025 | $504,730 | $119,263 | 2024-12 |
| Ashutosh the Love of Shiva Inc | Elgin | 501(c)(3) | 2024 | $500,209 | $300,209 | 2024-12 |
| Newberry County Hospital Foundation Inc | Newberry | 501(c)(3) | 1998 | $492,788 | $24.5 million | 2025-06 |
| Anderson Life Crisis Pregnancy Center Inc | Anderson | 501(c)(3) | 1990 | $486,120 | $597,860 | 2025-12 |
| Lowcountry Veterans Home | Charleston | 501(c)(3) | 2019 | $485,383 | $656,025 | 2026-01 |
| Anmed Health Auxiliary | Anderson | 501(c)(3) | 1964 | $476,232 | $791,792 | 2025-12 |
| Palmetto Free Clinic | Rock Hill | 501(c)(3) | 2008 | $465,871 | $897,133 | 2025-12 |
| Donate Life South Carolina | Greenville | 501(c)(3) | 1996 | $461,870 | $315,189 | 2025-12 |
| Solomons Home for the Aged | Sumter | 501(c)(3) | 1964 | $458,385 | $685,253 | 2025-12 |
| Arrhythmia Alliance | Hilton Head | 501(c)(3) | 2006 | $452,576 | $242,625 | 2025-12 |
| Foundation for Community Impact & Health Equity | Ridgeway | 501(c)(3) | 2020 | $451,935 | $26,989 | 2024-12 |
| Aiken Pregnancy Care Center Inc | Aiken | 501(c)(3) | 1994 | $443,478 | $696,904 | 2024-12 |
| Womens Enrichment Center | Lancaster | 501(c)(3) | 1997 | $438,259 | $212,426 | 2024-12 |
| Friends of Fisher House Charleston Inc | Charleston | 501(c)(3) | 2013 | $432,814 | $861,789 | 2025-12 |
| Emerson Rose Heart Foundation | Clemson | 501(c)(3) | 2012 | $408,109 | $632,379 | 2025-12 |
| Harvest Free Medical Clinic | North Charleston | 501(c)(3) | 2003 | $405,815 | $1.3 million | 2025-12 |
| Sumter Pregnancy Center | Sumter | 501(c)(3) | 1996 | $363,504 | $631,925 | 2025-12 |
| Sonshine Recovery Ministries | Dillon | 501(c)(3) | 2019 | $361,027 | $455,264 | 2025-12 |
| Jackson First Alert | Jackson | 501(c)(3) | 1989 | $360,358 | $181,718 | 2024-12 |
| Diannes Call | Columbia | 501(c)(3) | 2008 | $312,644 | $423,110 | 2025-12 |
| Free Medical Clinic of Aiken County | Aiken | 501(c)(3) | 1998 | $311,234 | $404,156 | 2024-12 |
| Heart Inclusive Arts Community | North Charleston | 501(c)(3) | 2014 | $290,782 | $92,105 | 2024-12 |
| Childsmiles Dental Inc | Mullins | 501(c)(3) | 2022 | $279,590 | $262,009 | 2024-12 |
| Good Samaritan Clinic | Lexington | 501(c)(3) | 2006 | $277,842 | $66,813 | 2025-12 |
| Edisto Indian Free Clinic | Ridgeville | 501(c)(3) | 2018 | $269,884 | $73,783 | 2025-12 |
| Lowcountry Equine-Assisted Psychotherapy | Wadmalaw Is | 501(c)(3) | 2005 | $264,943 | $101,671 | 2024-12 |
| Hope Womens Center Inc | Easley | 501(c)(3) | 1991 | $263,818 | $352,427 | 2024-12 |
| Arthrogryposis Multiplex Congenitasupport | Spartanburg | 501(c)(3) | 2007 | $253,239 | $397,399 | 2024-12 |
| Anderson Oconee Speech & Hearing Services Inc | Anderson | 501(c)(3) | 1970 | $245,145 | $116,222 | 2026-06 |
| Orangeburg Calhoun Free Medical Clinic | Orangeburg | 501(c)(3) | 2009 | $238,789 | $109,812 | 2025-12 |
| Clemson Free Clinic | Clemson | 501(c)(3) | 2005 | $237,867 | $583,249 | 2025-12 |
| New Holland Volunteer Fire Department Inc | Wagener | 501(c)(3) | 2003 | $232,363 | $414,795 | 2023-12 |
| Range Fore Hope Foundation | Blythewood | 501(c)(3) | 2021 | $226,899 | $157,365 | 2025-12 |
| Allegiance Home Care Inc | Lexington | 501(c)(3) | 2023 | $222,694 | $435 | 2024-12 |
| Cherokee Pregnancy Center Incorp | Gaffney | 501(c)(3) | 2005 | $214,748 | $685,751 | 2025-12 |
| Courageous Kidz Inc | N Charleston | 501(c)(3) | 2006 | $205,882 | $471,631 | 2025-12 |
| Free Medical Clinic of Newberry County Inc | Newberry | 501(c)(3) | 2004 | $196,322 | $209,558 | 2025-12 |
| Hope for Life Pregnancy Center | Lugoff | 501(c)(3) | 2004 | $191,099 | $246,358 | 2025-12 |
| Pallium India Inc | Simpsonville | 501(c)(3) | 2015 | $189,382 | $15,364 | 2025-12 |
| Medi Inc | N Charleston | 501(c)(3) | 2017 | $183,000 | $73,929 | 2024-12 |
| Comprehensive Psychiatric Care Specialists | Charleston | 501(c)(3) | 2015 | $182,490 | $69,809 | 2025-06 |
| Happy Hooves Inc | Marietta | 501(c)(3) | 2003 | $181,085 | $91,493 | 2024-12 |
| Charleston Community Research To Action Board | N Charleston | 501(c)(3) | 2014 | $169,773 | $119,451 | 2024-12 |
| Sickle Forward | Greenville | 501(c)(3) | 2023 | $168,023 | $235,014 | 2025-12 |
| Abbeville Area Medical Center Foundation | Abbeville | 501(c)(3) | 2001 | $157,535 | $581,768 | 2025-09 |
| Laurens County Cancer Association | Clinton | 501(c)(3) | 2012 | $153,883 | $251,402 | 2024-12 |
| Lets Walk | Charleston | 501(c)(3) | 2022 | $149,464 | $76,721 | 2025-12 |
| Hoofprints in the Sand Inc | Charleston | 501(c)(3) | 2023 | $144,369 | $18,607 | 2024-12 |
| Velos of SC Inc | Columbia | 501(c)(3) | 2024 | $135,437 | $7,955 | 2025-12 |
| South Carolina Association of Neurological Surgeons Inc | Greenville | 501(c)(3) | 2024 | $131,151 | $343,746 | 2025-12 |
| Coles Victory Lap | Greenville | 501(c)(3) | 2022 | $129,324 | $567,390 | 2024-12 |
| Savita Institute | Greenville | 501(c)(3) | 2023 | $128,000 | $433,340 | 2024-12 |
| Medical Ministries Inc | Summerville | 501(c)(3) | 2015 | $117,774 | $1,316 | 2026-05 |
| South Carolina Public Health Association | West Columbia | 501(c)(3) | 2002 | $117,052 | $181,443 | 2025-12 |
| Carolina Sunshine for Children Inc | Columbia | 501(c)(3) | 1984 | $116,622 | $413,323 | 2025-12 |
| Marion Rescue Squad Inc | Marion | 501(c)(3) | 1996 | $116,363 | $532,826 | 2025-12 |
| Carolina Teen Center | Summerville | 501(c)(3) | 2016 | $111,009 | $1 | 2025-12 |
| Berkeley County Emergency Service Training Center Inc | Moncks Corner | 501(c)(3) | 1997 | $106,806 | $370,662 | 2025-06 |
| Edisto Island Community Clinic | Edisto Island | 501(c)(3) | 2024 | $101,573 | $110,383 | 2025-12 |
| Self Regional Healthcare Auxiliary | Greenwood | 501(c)(3) | 1976 | $98,765 | $134,909 | 2025-09 |
| Resilient Arrow Project | Mt Pleasant | 501(c)(3) | 2023 | $97,139 | $96,889 | 2025-12 |
| South Carolina Witness Project | Boiling SPGS | 501(c)(3) | 2023 | $93,430 | $0 | 2025-06 |
| Peapot Jones | Little River | 501(c)(3) | 2016 | $93,376 | $923,337 | 2024-12 |
| Southeastern Medical International Inc | Florence | 501(c)(3) | 2006 | $91,859 | $45,365 | 2025-12 |
| The Ridge Healthcare Foundation Inc | Edgefield | 501(c)(3) | 2019 | $91,726 | $197,268 | 2025-09 |
| Prisma Health Ltach - Baptist | Greenville | 501(c)(3) | 2026 | $86,779 | $1.6 million | 2025-09 |
| Islands Against Cancer Inc | Charleston | 501(c)(3) | 2022 | $85,653 | $32,717 | 2025-12 |
| Conway Hospital Auxiliary | Conway | 501(c)(3) | 2001 | $85,313 | $66,696 | 2025-12 |
| Hospital Auxiliary of Aiken County Inc | Aiken | 501(c)(3) | 1977 | $82,014 | $452,418 | 2025-12 |
| Independent Living Inc | Sumter | 501(c)(3) | 1994 | $78,668 | $127,627 | 2025-06 |
| South Carolina Occupational Therapy Association Inc | Ravenel | 501(c)(6) | 2023 | $78,074 | $61,654 | 2025-12 |
| Esta Lucecita | Myrtle Beach | 501(c)(3) | 2020 | $74,924 | $59,874 | 2025-12 |
| South Carolina Community Health Worker Association | Columbia | 501(c)(3) | 2018 | $74,171 | $313,515 | 2024-12 |
| Alzfoundation Inc | Myrtle Beach | 501(c)(3) | 2022 | $68,600 | $33,200 | 2025-12 |
| Sole Stepping LLC | Batesburg | 501(c)(3) | 2019 | $68,421 | $16,358 | 2024-12 |
| Med-I-Assist Inc | Bluffton | 501(c)(3) | 2008 | $67,050 | $43,474 | 2025-12 |
| Living Bread Inc | Greenville | 501(c)(3) | 2013 | $66,765 | $9,810 | 2025-12 |
| Pro-Life Charleston | Charleston | 501(c)(3) | 2017 | $66,171 | $44,728 | 2025-06 |
| Unitsusa Org Inc | Seneca | 501(c)(3) | 2015 | $64,648 | $6,188 | 2025-12 |
| South Carolina Perinatal Association Inc | Columbia | 501(c)(3) | 1991 | $64,004 | $104,066 | 2024-12 |
| South Carolina Dental Hygienists Association | Travelers RST | 501(c)(3) | 2016 | $63,065 | $11,895 | 2025-12 |
| Palmetto Medical Dental Pharmaceutical Association | Mauldin | 501(c)(3) | 2022 | $61,625 | $24,781 | 2025-12 |
| Healing Hands Clinic | Summerville | 501(c)(3) | 2026 | $59,700 | $69,528 | 2025-12 |
| Union County Pregnancy Center | Union | 501(c)(3) | 1998 | $57,641 | $158,645 | 2025-12 |
| Hope for Hooves Rescue | North Augusta | 501(c)(3) | 2020 | $57,382 | $6,684 | 2025-12 |
| Academy of General Dentistry | Mt Pleasant | 501(c)(6) | 1972 | $56,301 | $166,076 | 2025-12 |
| Coosaw Creek Cancer Research Charity Fund | N Charleston | 501(c)(3) | 2025 | $54,231 | $4,861 | 2025-12 |
| The Heart2heart Foundation Inc | Rock Hill | 501(c)(3) | 2013 | $50,253 | $41,800 | 2025-12 |
| Deeper Healing Foundation Incorporated | Daniel Island | 501(c)(3) | 2021 | $49,200 | $30,051 | 2024-12 |
| Great Falls Rescue Squad Association | Great Falls | 501(c)(3) | 2024 | $48,228 | $4,559 | 2025-12 |
| Michael L Rogers Foundation | Columbia | 501(c)(3) | 2024 | $48,228 | $29,251 | 2024-12 |
| Miracle of the Hudson | Fort Mill | 501(c)(3) | 2022 | $47,776 | $17,710 | 2024-12 |
| Friends of Santa Claus Inc | Tega Cay | 501(c)(3) | 1996 | $47,445 | $180,757 | 2025-12 |
| Upper Midlands Rural Health Network | Chester | 501(c)(3) | 2007 | $40,283 | $114,517 | 2024-09 |
| Dillon County Free Medical Clinic | Dillon | 501(c)(3) | 2012 | $38,383 | $51,981 | 2023-12 |
| Let S Saddle Up Inc | Laurens | 501(c)(3) | 2015 | $36,742 | $3,346 | 2025-12 |
| Prisma Health Baptist Parkridge Auxiliary | Columbia | 501(c)(3) | 2014 | $35,703 | $205,182 | 2025-12 |
| T O Missions Worldwide Inc | Charleston | 501(c)(3) | 2024 | $34,740 | $22,683 | 2024-12 |
| Heather Perkins Trew Foundation | Hilton Head | 501(c)(3) | 2010 | $33,400 | $4,185 | 2025-12 |
| Taste of Health International | Gaston | 501(c)(3) | 2024 | $32,616 | $408 | 2025-12 |
| Shrine Bowl of the Carolinas | Columbia | 501(c)(3) | 1952 | $31,215 | $169,564 | 2026-02 |
| Palmetto Equestrian Therapeutic Riding Program | Clinton | 501(c)(3) | 2010 | $30,237 | $23,262 | 2025-12 |
| Carolinas Chapter of America Society of Hypertension | Mt Pleasant | 501(c)(3) | 2001 | $28,922 | $283,757 | 2025-09 |
| Alexa R Good A L S Foundation | Rock Hill | 501(c)(3) | 2001 | $28,291 | $399,413 | 2025-12 |
| Veterans Hall of Heroes Inc | Greenwood | 501(c)(19) | 2016 | $28,070 | $10,887 | 2025-12 |
| Broad River Healthcare Inc | Beaufort | 501(c)(3) | 1997 | $25,700 | $3.3 million | 2025-09 |
| Hammer Out Pediatric Cancer Corp | Charleston | 501(c)(3) | 2019 | $25,569 | $1 | 2023-12 |
| South Carolina Medical Association Alliance | Columbia | 501(c)(3) | 1977 | $24,204 | $266,504 | 2025-06 |
| Wrens Village | Fort Mill | 501(c)(3) | 2018 | $21,161 | $82,793 | 2025-12 |
| Disaster Anesthesia Inc | Charleston | 501(c)(3) | 2025 | $20,397 | $4,163 | 2025-12 |
| Society for Opioid Free Anesthesia | Daniel Island | 501(c)(3) | 2022 | $19,665 | $16,975 | 2025-12 |
| Cancer Heroes of the Carolinas | Murrells Inlt | 501(c)(3) | 2018 | $19,189 | $24,134 | 2024-12 |
| Grand Strand Auxiliary Inc | Myrtle Beach | 501(c)(3) | 1978 | $17,941 | $22,263 | 2026-04 |
| Brendas Angels | Aiken | 501(c)(3) | 2016 | $14,456 | $154 | 2025-12 |
| Anmed Health System | Anderson | 501(c)(3) | 1987 | $12,415 | $1.09 billion | 2024-12 |
| Tidelands Health Holdings | Georgetown | 501(c)(3) | 2022 | $10,000 | $1 million | 2025-09 |
| Iron Disorders Institute | Greenville | 501(c)(3) | 1998 | $8,365 | $28,267 | 2026-06 |
| Louies Kids Inc | Isle of Palms | 501(c)(3) | 2005 | $7,976 | $3,615 | 2023-12 |
| Stroke Buddies By and for Stroke Survivors | Murrells Inlt | 501(c)(3) | 2022 | $6,710 | $1,129 | 2025-12 |
| Asibiti | Lexington | 501(c)(3) | 2022 | $3,244 | $4,148 | 2024-12 |
| Fairfield Medical Health Foundation | Winnsboro | 501(c)(3) | 2024 | $3,000 | $1,947 | 2024-12 |
| Paraclete Foundation Inc | Taylors | 501(c)(3) | 2018 | $2,962 | $18,870 | 2024-12 |
| Juvenile Diabetes Good Care Support | Irmo | 501(c)(3) | 2020 | $1,812 | $6,532 | 2023-12 |
| Aynor Volunteer Rescue Squad Inc | Aynor | 501(c)(3) | 1998 | $1,576 | $20,246 | 2025-12 |
| Black Doulas of Columbia Collective | Columbia | 501(c)(3) | 2025 | $1,033 | $322 | 2024-12 |
| The 621 Foundation | Greenville | 501(c)(3) | 2026 | $562 | $506 | 2025-12 |
| Brain Restoration Ministries Inc | Fort Mill | 501(c)(3) | 2015 | $370 | $322,742 | 2025-12 |
| Mercy in Me Free Medical Clinic | Cheraw | 501(c)(3) | 2009 | $200 | $368,859 | 2025-12 |
| 1 Kings 17 Foundation | Irmo | 501(c)(3) | 2022 | $0 | $0 | 2025-10 |
| 4myliferx | Columbia | 501(c)(3) | 2021 | $0 | $0 | 2024-12 |
| A Family Affair Living Our Best Life | Orangeburg | 501(c)(3) | 2025 | $0 | $0 | 2025-12 |
| A Womans Way Inc | Rock Hill | 501(c)(3) | 2016 | $0 | $0 | 2025-12 |
| Aaig Foundation | Georgetown | 501(c)(3) | 2021 | $0 | $0 | 2025-12 |
| Abbeville County Memorial Hospital | Abbeville | 501(c)(3) | 1954 | |||
| Aerocare Connect | Little River | 501(c)(3) | 2026 | $0 | $0 | 2025-12 |
| Agd- Always Giving Divine | Greenville | 501(c)(3) | 2019 | $0 | $0 | 2024-12 |
| Alejandro Espaillat Foundation | Elgin | 501(c)(3) | 2025 | |||
| Allendale County Hospital Board | Fairfax | 501(c)(3) | 1981 | |||
| American Art Therapy Association Inc | Charleston | 501(c)(3) | 1996 | $0 | $0 | 2025-12 |
| American Muslim Medical Relief Team | York | 501(c)(3) | 2023 | $0 | $0 | 2026-03 |
| Angels of Mercy Health Care Center | Summerville | 501(c)(3) | 2004 | $0 | $0 | 2024-12 |
| Apple Breast Cancer Warrior Foundation | Myrtle Beach | 501(c)(3) | 2019 | $0 | $0 | 2025-12 |
| Ares Medical Group | Johns Island | 501(c)(3) | 2026 | |||
| Ascend Missions International Inc | Gaffney | 501(c)(3) | 2000 | $0 | $0 | 2025-12 |
| Ashutosh Health Organization Inc | Elgin | 501(c)(3) | 2025 | |||
| Association for Professionals in Infection CTRL & Epidemiology Inc | Greenville | 501(c)(3) | 1975 | $0 | $0 | 2025-12 |
| Augusta Homeless Organization | North Augusta | 501(c)(3) | 2021 | $0 | $0 | 2024-12 |
| Barefeet Foot Clinic | Conestee | 501(c)(3) | 2022 | $0 | $0 | 2025-12 |
| Beaufort County Memorial Hospital | Beaufort | 501(c)(3) | 1980 | 2009-09 | ||
| Beaufort Physician Partners | Beaufort | 501(c)(3) | 2014 | $0 | $2,236 | 2025-09 |
| Beauty From Ashes Surgical Ministry | Fort Mill | 501(c)(3) | 2025 | $0 | $0 | 2025-12 |
| Bella Clinical Care | Columbia | 501(c)(3) | 2025 | |||
| Bells Home Health Professionals Incorporated | Columbia | 501(c)(3) | 2025 | |||
| Below 104 | Anderson | 501(c)(3) | 2021 | $0 | $0 | 2024-12 |
| Belton Emergency Medical Services Belton Ems | Belton | 501(c)(3) | 1970 | $0 | $0 | 2025-12 |
| Bethlehem Therapeutic Riding Stable | Timmonsville | 501(c)(3) | 2009 | $0 | $0 | 2025-12 |
| Beyond Bedding Safehaven Services | Darlington | 501(c)(3) | 2026 | |||
| Bifrost Health Advocate Services | Piedmont | 501(c)(3) | 2018 | $0 | $0 | 2023-12 |
| Big Sister Little Sister We Hear You Cry | Columbia | 501(c)(3) | 2021 | $0 | $0 | 2025-12 |
| Black Sheep Farm | Simpsonville | 501(c)(3) | 2009 | $0 | $0 | 2025-12 |
| Blessings in Motion | Anderson | 501(c)(3) | 2026 | |||
| Bradens Butterflies Inc | Charleston | 501(c)(3) | 2016 | $0 | $0 | 2025-09 |
| Breaking Ribbons | Charleston | 501(c)(3) | 2026 | |||
| Breast Implant Safety Alliance Inc | Johns Island | 501(c)(3) | 2019 | $0 | $0 | 2023-12 |
| Breath of Life Outreach | Elgin | 501(c)(3) | 2024 | $0 | $0 | 2026-06 |
| Breathe Clear Foundation | Charleston | 501(c)(3) | 2014 | $0 | $0 | 2025-12 |
| Brenda D Perkins | Georgetown | 501(c)(3) | 2021 | $0 | $0 | 2025-12 |
| Brookes Blades of Hope Foundation | Ravenel | 501(c)(3) | 2026 | |||
| Bubbas Light Inc | Myrtle Beach | 501(c)(3) | 2020 | $0 | $0 | 2025-12 |
| Buncombe Street Methodist Church Endowment Fund Inc | Greenville | 501(c)(3) | 2025 | |||
| Burn Care International Inc | Florence | 501(c)(3) | 2010 | $0 | $0 | 2025-12 |
| Cancer Relief Fund | Charleston | 501(c)(3) | 2016 | $0 | $0 | 2025-06 |
| Care One Respite Services of SC | Myrtle Beach | 501(c)(3) | 2026 | $0 | $0 | 2025-12 |
| Care for Rare Foundation | Rock Hill | 501(c)(3) | 2026 | |||
| Carey Cox Wyatt Charitable Foundation Inc | Kiawah Island | 501(c)(3) | 1994 | $1.3 million | 2025-12 | |
| Caribbean Access To Relief Essentia L Care and Support | Columbia | 501(c)(3) | 2026 | |||
| Caring Bridge | Greenville | 501(c)(3) | 2022 | $0 | $0 | 2023-12 |
| Caring Care Bears | Columbia | 501(c)(3) | 2024 | |||
| Caring Community Nurses CDC | Greenwood | 501(c)(3) | 2017 | $0 | $0 | 2025-12 |
| Caring Meds Inc | Columbia | 501(c)(3) | 2016 | $0 | $0 | 2025-12 |
| Carolina Chapter National Association of Diversity Officers | Charleston | 501(c)(3) | 2023 | $0 | $0 | 2024-06 |
| Carolina Community Medical Access I Nitiative | Columbia | 501(c)(3) | 2026 | |||
| Carolina Ehealth Alliance | Charleston | 501(c)(3) | 2014 | $0 | $0 | 2025-12 |
| Carolina Family Care Inc | Charleston | 501(c)(3) | 2026 | |||
| Carolina Immigrant Health Initiative | Piedmont | 501(c)(3) | 2024 | $0 | $0 | 2024-12 |
| Carolinas Cross Cultural Health Services | Florence | 501(c)(3) | 2014 | $0 | $0 | 2025-12 |
| Charlotte Celiac Connection | Fort Mill | 501(c)(3) | 2007 | $0 | $0 | 2025-12 |
| Chika Foundation Inc | Blythewood | 501(c)(3) | 2025 | |||
| Christian Medical Clinic at Saint Andrews Church | Mt Pleasant | 501(c)(3) | 2025 | |||
| Clemson Remote Area Medical Inc | Columbia | 501(c)(3) | 2024 | $0 | $0 | 2025-06 |
| Clinical Nurse Leader Association | Columbia | 501(c)(3) | 2011 | $0 | $0 | 2025-12 |
| Coastal Center for Mind-Body Therapies Inc | Surfside BCH | 501(c)(3) | 2003 | $0 | $0 | 2024-12 |
| Coastal Plain Rural Health Network | Florence | 501(c)(3) | 2008 | $0 | $0 | 2025-12 |
| Collective Balance | Greer | 501(c)(3) | 2021 | $0 | $0 | 2025-12 |
| Committee On Graduate Medical Education for Urgent Care Medicine | N Myrtle BCH | 501(c)(3) | 2017 | $0 | $0 | 2024-12 |
| Community Health & Services Partners Inc | Mullins | 501(c)(3) | 2014 | $0 | $0 | 2025-12 |
| Community Health Initiatives International | Leesville | 501(c)(3) | 2015 | $0 | $0 | 2024-12 |
| Community Sprouts | Aiken | 501(c)(3) | 2026 | $0 | $0 | 2025-12 |
| Community of the Modern Message | Myrtle Beach | 501(c)(3) | 2025 | $0 | $0 | 2024-12 |
| Considerate Care Caps | Mauldin | 501(c)(3) | 2025 | $0 | $0 | 2025-12 |
| Conway Hospital Anesthesia Professional Services | Conway | 501(c)(3) | 2010 | $0 | $172,626 | 2025-09 |
| Conway Hospital Long Term Care Services Inc | Conway | 501(c)(3) | 1988 | $0 | $603,720 | 2025-09 |
| Conway Parent Inc | Conway | 501(c)(3) | 2026 | $0 | $175 million | 2025-09 |
| Cornerstone Health Builders | Columbia | 501(c)(3) | 2026 | |||
| Delta Eta Chapter of Chi Eta Phi Sorority Inc | Columbia | 501(c)(3) | 2016 | $0 | $0 | 2025-05 |
| Dementia Aware of the Carolinas | Fort Mill | 501(c)(3) | 2023 | $0 | $0 | 2025-12 |
| Dental Share Network | Clinton | 501(c)(3) | 2018 | $0 | $0 | 2025-12 |
| Dew2 Global Inc | Aiken | 501(c)(3) | 2025 | $0 | $0 | 2025-12 |
| Dinka Link Inc | Anderson | 501(c)(3) | 2014 | $0 | $0 | 2025-06 |
| Divine Health Education | Cross | 501(c)(3) | 2019 | $0 | $0 | 2024-12 |
| Divine Trinity House of Hope Inc | Greenville | 501(c)(3) | 2024 | $0 | $0 | 2020-12 |
| Donors of Life Foundation Inc | Greer | 501(c)(3) | 2014 | $0 | $0 | 2023-12 |
| Dr Hope & Health Inc | Greenville | 501(c)(3) | 2025 | $0 | $0 | 2025-12 |
| E&M Foundation | Ridgeland | 501(c)(3) | 2021 | $0 | $0 | 2025-12 |
| Edisto Health Foundation Inc | Orangeburg | 501(c)(3) | 2006 | |||
| Edisto Regional Health Services Inc | Orangeburg | 501(c)(3) | 1998 | |||
| Electric City Wellness Foundation | Anderson | 501(c)(3) | 2026 | |||
| Elizabeth Foundation | Hampton | 501(c)(3) | 2022 | $0 | $0 | 2025-12 |
| Elliot and Eleanor Foundation | Kiawah Island | 501(c)(3) | 2014 | $7.4 million | 2025-12 | |
| Emergency Medical Residency | Columbia | 501(c)(3) | 2013 | $0 | $0 | 2025-12 |
| Emotions 4life | Bennettsville | 501(c)(3) | 2021 | $0 | $0 | 2023-12 |
| Empower Health | Fountain Inn | 501(c)(3) | 2025 | |||
| Ending A Wanted Pregnancy Inc | Murrells Inlt | 501(c)(3) | 2025 | $0 | $0 | 2025-12 |
| Expect Great Health | Mt Pleasant | 501(c)(3) | 2022 | $0 | $0 | 2023-12 |
| Fairfield Family Life Coalition | Columbia | 501(c)(3) | 2003 | $0 | $0 | 2024-12 |
| Faith & Support Ministry | Pelzer | 501(c)(3) | 2018 | $0 | $0 | 2025-12 |
| Fast Way Out | Fort Mill | 501(c)(3) | 2022 | $0 | $0 | 2024-12 |
| Fetter Better Care Foundation | Charleston | 501(c)(3) | 2026 | |||
| Fidelis Foundation of Myrtle Beach Inc | Murrells Inlt | 501(c)(3) | 2011 | $0 | $0 | 2025-12 |
| Fletcher-Gwaltney Shared Services Inc | Bamberg | 501(c)(3) | 1987 | $0 | $0 | 2025-12 |
| Flourish Family Medicine and Obgyn | Greenville | 501(c)(3) | 2025 | |||
| For Joy Inc | Gaffney | 501(c)(3) | 2024 | |||
| Futuremed | Orangeburg | 501(c)(3) | 2023 | $1 | 2025-12 | |
| Gary Ostroski Sr Foundation Inc | Charleston | 501(c)(3) | 2024 | |||
| Get Right Health and Fitness | Lexington | 501(c)(3) | 2024 | |||
| Ghirlz in the Hood A Sisterhood | Goose Creek | 501(c)(3) | 2021 | $0 | $0 | 2025-12 |
| Gifted Hands Homecare | Fort Mill | 501(c)(3) | 2018 | $0 | $0 | 2025-12 |
| Give Thanks Project Inc | Tega Cay | 501(c)(3) | 2024 | $0 | $0 | 2025-12 |
| Given Wings Inc | Gray Court | 501(c)(3) | 2017 | $0 | $0 | 2025-12 |
| Global Enterprise Medical Solutions | Irmo | 501(c)(3) | 2025 | $0 | $0 | 2025-12 |
| Global Institute of Mind Body Wellness | North Augusta | 501(c)(3) | 2019 | $0 | $0 | 2023-12 |
| Global Med | Spartanburg | 501(c)(3) | 2012 | $0 | $0 | 2025-12 |
| Gold Star Cares Foundation | Florence | 501(c)(3) | 2025 | |||
| Governor Robert Daniell Foundation | Greenville | 501(c)(3) | 2013 | $0 | $0 | 2025-05 |
| Greenville Health Authority | Greenville | 501(c)(3) | 1944 | 2016-09 | ||
| Grove Park Pharmacy Hospice Care Charitable Foundation | Orangeburg | 501(c)(3) | 2012 | $0 | $0 | 2024-12 |
| Harmony Health Foundation | Duncan | 501(c)(3) | 2025 | |||
| Harper Strong Foundation | Johns Island | 501(c)(3) | 2023 | $0 | $0 | 2025-12 |
| Hartwell Self-Healing Center Under Gods Supervision Inc | Fair Play | 501(c)(3) | 2011 | $0 | $0 | 2024-12 |
| Healing Endometriosis Research Foundation | Greenville | 501(c)(3) | 2024 | |||
| Health Education Consultants Inc | Irmo | 501(c)(3) | 2014 | $0 | $0 | 2024-12 |
| Health Fund for Children | Mt Pleasant | 501(c)(3) | 2020 | $0 | $0 | 2026-06 |
| Health Hope & Healing | Columbia | 501(c)(3) | 2024 | |||
| Health Partners of the Lakelands | Greenwood | 501(c)(3) | 2021 | $0 | $1 | 2025-09 |
| Healthcare Empowerment Access and Logistics | Florence | 501(c)(3) | 2025 | $0 | $0 | 2025-12 |
| Healthy Lifestyle Network | Charleston | 501(c)(3) | 2007 | $0 | $0 | 2025-12 |
| Healthy Solutions I O Inc | Summerville | 501(c)(3) | 2022 | $0 | $0 | 2025-12 |
| Heart Strong Carolina | Pendleton | 501(c)(3) | 2026 | $0 | $0 | 2026-01 |
| Heart of Gold Foundation | Summerville | 501(c)(3) | 2023 | $0 | $0 | 2024-12 |
| Heavens Hope Inc | Timmonsville | 501(c)(3) | 2017 | $0 | $0 | 2024-12 |
| Helping Hands Heal Families Inc | Murrells Inlt | 501(c)(3) | 2022 | $0 | $0 | 2024-12 |
| His Hands Wellness Ministry | Rock Hill | 501(c)(3) | 2023 | $0 | $0 | 2025-12 |
| Hispanos Comunidad | Easley | 501(c)(3) | 2025 | $0 | $0 | 2024-12 |
| Holding Mothers Nonprofit | Duncan | 501(c)(3) | 2025 | $0 | $0 | 2025-12 |
| Holistic Wellness Fair | Aiken | 501(c)(3) | 2017 | $0 | $0 | 2025-12 |
| Holy Grace Ministry | Taylors | 501(c)(3) | 2018 | $0 | $0 | 2025-12 |
| Honored Podiatry Services Inc | Columbia | 501(c)(3) | 2022 | $0 | $0 | 2024-12 |
| Hope Smiles Together Inc | Mt Pleasant | 501(c)(3) | 2025 | |||
| Hormone Healthy Inc | Clover | 501(c)(3) | 2025 | $0 | $0 | 2025-12 |
| House of Hope of the Midlands | Irmo | 501(c)(3) | 2021 | |||
| Hypertension and Diabetes Prevention and Treatment Center | Florence | 501(c)(3) | 2019 | $0 | $0 | 2023-12 |
| I - Am Institute | Myrtle Beach | 501(c)(3) | 2025 | $1 | 2020-12 | |
| Inflammatory Disease Reseach Foundation | Lexington | 501(c)(3) | 2019 | $0 | $0 | 2024-12 |
| Insights Festival | Spartanburg | 501(c)(3) | 2019 | $0 | $0 | 2023-12 |
| Institute of Body and Mind Inc | Columbia | 501(c)(3) | 2025 | |||
| Integrity Training Center Inc | North Charleston | 501(c)(3) | 2024 | $0 | $0 | 2025-12 |
| Interim Hospice Fund | N Charleston | 501(c)(3) | 2025 | $0 | $0 | 2025-12 |
| International Humanitarian Relief Inc | York | 501(c)(3) | 2014 | $2,000 | 2025-12 | |
| Ion South Carolina | Columbia | 501(c)(3) | 2024 | $0 | $104,062 | 2025-12 |
| J Romero Foundation | Beaufort | 501(c)(3) | 2026 | |||
| Jakyve Healthcare Consulting & Education | Irmo | 501(c)(3) | 2021 | $0 | $0 | 2025-12 |
| James Grier and Laura Easterby Ferg Uson Meditation Garden | Laurens | 501(c)(3) | 2002 | $0 | $0 | 2024-12 |
| Jeans Fund of SC Inc | Charleston | 501(c)(3) | 2021 | $0 | $0 | 2025-12 |
| Just Believe 4newbeginnings Inc | Six Mile | 501(c)(3) | 2026 | $0 | $0 | 2025-06 |
| KD Sickle Cell Foundation | Kingstree | 501(c)(3) | 2026 | $0 | $0 | 2025-12 |
| Kanga Kids Inc | Fort Mill | 501(c)(3) | 2018 | $0 | $0 | 2025-12 |
| Karam J Awan Foundation | Simpsonville | 501(c)(3) | 2022 | $0 | $0 | 2025-12 |
| Keep Wellness Simple Foundation | Columbia | 501(c)(3) | 2026 | |||
| Kemetic Institute for Leadership An D Human Development | Columbia | 501(c)(3) | 2015 | $0 | $0 | 2025-12 |
| Kids With Diabetes | Simpsonville | 501(c)(3) | 2025 | $0 | $0 | 2025-12 |
| Kind Aid Initiative Inc | Summerville | 501(c)(3) | 2026 | |||
| Kingdom Living On Earth Foundation | Aiken | 501(c)(3) | 2024 | |||
| Knee Chest Society | Summerville | 501(c)(3) | 2025 | $0 | $0 | 2025-12 |
| La Leche League International Inc | Longs | 501(c)(3) | 2017 | $0 | $0 | 2026-03 |
| Lakeview Assisted Living Inc | Anderson | 501(c)(3) | 1976 | $0 | $0 | 2025-12 |
| Lambs Hope Inc | Myrtle Beach | 501(c)(3) | 2012 | $0 | $0 | 2025-12 |
| Lamplighters Ministries Worship Center Inc | Fort Mill | 501(c)(3) | 2024 | $0 | $0 | 2025-12 |
| Laurens Area Medical Associates LLC | Clinton | 501(c)(3) | 2012 | |||
| Laurens County Health Care System | Clinton | 501(c)(3) | 1988 | |||
| Legacy - Upstate | Lyman | 501(c)(3) | 2026 | |||
| Legacy of Hope Nelson Williams McFadden Cancer Foundation | Columbia | 501(c)(3) | 2025 | |||
| Lets Talk Optimistic | Columbia | 501(c)(3) | 2024 | $0 | $0 | 2025-12 |
| Life Community Development Corporat Ion | Williston | 501(c)(3) | 2026 | |||
| Living Well Community Coalition | Marion | 501(c)(3) | 2026 | |||
| Loris Community Hospital District | Loris | 501(c)(3) | 1985 | |||
| Loving Arms Community Development | Kingstree | 501(c)(3) | 2017 | $0 | $0 | 2025-12 |
| Lymph Love | Myrtle Beach | 501(c)(3) | 2026 | |||
| Marlboro County Rescue Squad Inc | Bennettsville | 501(c)(3) | 1979 | $0 | $0 | 2023-12 |
| Matthew Loves Books | Spartanburg | 501(c)(3) | 2012 | $0 | $0 | 2025-12 |
| McLeod Health Innovation | Florence | 501(c)(3) | 2021 | $0 | $0 | 2025-12 |
| Medical Society of Saint Anthony Zaccaria Inc | N Myrtle BCH | 501(c)(3) | 1997 | $0 | $0 | 2025-12 |
| Medical Staff of Grand Strand General Hospital of Myrtle Beach | Myrtle Beach | 501(c)(4) | 2026 | |||
| Medical University Hospital Authority | Charleston | 501(c)(3) | 2004 | 2025-06 | ||
| Medical University Hospital Imaging Center | Charleston | 501(c)(3) | 2022 | |||
| Midlands Harm Reduction Collective | Lexington | 501(c)(3) | 2026 | |||
| Minority Women in Medicine | Summerville | 501(c)(3) | 2022 | $0 | $0 | 2025-12 |
| Miss Mary Community Development Corporation | Rock Hill | 501(c)(3) | 2013 | $0 | $0 | 2024-12 |
| Mission 210 | Fort Mill | 501(c)(3) | 2024 | $0 | $0 | 2025-12 |
| Mission Restored | Summerville | 501(c)(3) | 2026 | |||
| Miyinspiration | Greenville | 501(c)(3) | 2020 | $0 | $0 | 2025-12 |
| Model Behavior | Hollywood | 501(c)(3) | 2026 | |||
| Monka Foundation | Charleston | 501(c)(3) | 2022 | $5,671 | 2025-12 | |
| Morgans Hope | Mauldin | 501(c)(3) | 2023 | $0 | $0 | 2024-12 |
| Morris Street Baptist Church Outreach Program | Charleston | 501(c)(3) | 2003 | |||
| Mothers Against Medical Error | Columbia | 501(c)(3) | 2013 | $0 | $1 million | 2025-12 |
| Motivated Woman | West Columbia | 501(c)(3) | 2022 | $0 | $0 | 2024-10 |
| My Preemie and Yours | Summerville | 501(c)(3) | 2022 | $0 | $0 | 2024-07 |
| Myochiro | Aiken | 501(c)(3) | 2024 | $0 | $0 | 2025-12 |
| National Black Womens Hiv Aids Network | Columbia | 501(c)(3) | 2012 | $0 | $0 | 2024-12 |
| Neohero Foundation | Summerville | 501(c)(3) | 2025 | $0 | $0 | 2025-12 |
| Nest Diagnostics Inc | Fort Mill | 501(c)(3) | 2025 | $0 | $0 | 2025-12 |
| Newberry County Memorial Hospital | Newberry | 501(c)(3) | 1951 | |||
| Nikia R Noisette Sickle Cell Foundation | Summerville | 501(c)(3) | 2025 | |||
| Northeastern Rural Health Network Incorporated | Bennettsville | 501(c)(3) | 2011 | $0 | $0 | 2025-09 |
| Nurses for Human Dignity Inc | Myrtle Beach | 501(c)(3) | 2026 | |||
| Nutifafa Shelter | Seneca | 501(c)(3) | 2020 | $0 | $0 | 2026-05 |
| On Point Ems Network | Saluda | 501(c)(3) | 2019 | $0 | $0 | 2025-12 |
| Oncohelper Ai Inc | Manning | 501(c)(3) | 2025 | |||
| Optimal Soul Foundation | Greenville | 501(c)(3) | 2022 | $0 | $0 | 2025-12 |
| PH Spe I Inc | Charleston | 501(c)(3) | 2026 | |||
| Pain To Triumph | Columbia | 501(c)(3) | 2022 | $0 | $0 | 2025-12 |
| Palmetto Association of Licensed Midwives | Lexington | 501(c)(3) | 2015 | $0 | $0 | 2025-12 |
| Palmetto Regional Wellness Board Incorporated | Moncks Corner | 501(c)(3) | 2025 | |||
| Parent and Child Enrichment Program | Irmo | 501(c)(3) | 2022 | $0 | $0 | 2025-12 |
| Partners for A Better Community | N Charleston | 501(c)(3) | 2023 | $0 | $0 | 2025-12 |
| Pediatric Foundation for Rare Diseases Inc | Bluffton | 501(c)(3) | 2024 | $0 | $0 | 2025-12 |
| Piedmont Health Foundation | Greenville | 501(c)(3) | 1992 | $2.7 million | 2025-12 | |
| Pink Ribbon Gals Foundation Inc | Indian Land | 501(c)(3) | 2024 | $0 | $0 | 2025-12 |
| Pink Smile Promise | Lancaster | 501(c)(3) | 2018 | $0 | $0 | 2025-12 |
| Polo Community of Aiken Fund | Aiken | 501(c)(3) | 2025 | |||
| Portal Medical Mission Inc | West Columbia | 501(c)(3) | 2011 | $0 | $0 | 2023-12 |
| Power Kids Fitness | Travelers RST | 501(c)(3) | 2018 | $0 | $0 | 2023-12 |
| Preemies of the Carolinas Inc | Fort Mill | 501(c)(3) | 2017 | $0 | $0 | 2025-12 |
| Pregnancy Hypertension Awareness Center of South Carolina Phac SC | Columbia | 501(c)(3) | 2024 | |||
| Prisma Health Eastern Tennessee | Greenville | 501(c)(3) | 2025 | $0 | $1 | 2025-09 |
| Project Assistance in Delhi | Spartanburg | 501(c)(3) | 2018 | $0 | $0 | 2025-12 |
| Proud Foundation | Denmark | 501(c)(3) | 2013 | $0 | $0 | 2025-12 |
| Providence Care Foundation Inc | Rock Hill | 501(c)(3) | 2024 | |||
| Public Health Advocacy and Support Network | Blythewood | 501(c)(3) | 2025 | $0 | $0 | 2025-12 |
| Public Health Innovations in Research & Development | Columbia | 501(c)(3) | 2014 | $0 | $0 | 2025-12 |
| Purple Crusaders | Cheraw | 501(c)(3) | 2023 | $0 | $0 | 2025-12 |
| Qei-Life Line Inc | Greenwood | 501(c)(3) | 2025 | |||
| RCS Home Sweet Home | York | 501(c)(3) | 2014 | $0 | $0 | 2025-12 |
| Ray and Charyl Schroeder Grace Foundation | Woodruff | 501(c)(3) | 1997 | $3.1 million | 2025-12 | |
| Reece Holbrook Win Anyway Foundation Inc | Mt Pleasant | 501(c)(3) | 2013 | $0 | $0 | 2024-12 |
Every nonprofit in South Carolina
Read from the IRS Exempt Organizations Business Master File, updated by the IRS on October 24, 2026 and rebuilt here every morning. Revenue and assets are from each organization's latest filing as the IRS lists it; the IRS record is the official one. Organizations only: no people are named on these pages.