Data / Nonprofits / South Carolina / Diseases, disorders and medical disciplines
Diseases, disorders and medical disciplines nonprofits in South Carolina: 195 registered with the IRS
195 diseases, disorders and medical disciplines nonprofits are registered with the IRS in South Carolina, 194 of them 501(c)(3) charities; the 74 that report revenue took in $49.4 million. The most are in Columbia (21), Charleston (16), Summerville (16). The largest by revenue: Affinity Health Center ($25.6 million), National Federation of the Blind of South Carolina ($1.8 million), South Carolina Autism Society Inc ($1.6 million).
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Every organization, largest by revenue first
| Organization | City | Type | Since | Revenue | Assets | Filing |
|---|---|---|---|---|---|---|
| Affinity Health Center | Rock Hill | 501(c)(3) | 2000 | $25.6 million | $29.1 million | 2025-12 |
| National Federation of the Blind of South Carolina | Columbia | 501(c)(3) | 1970 | $1.8 million | $1.9 million | 2024-12 |
| South Carolina Autism Society Inc | West Columbia | 501(c)(3) | 2004 | $1.6 million | $509,833 | 2024-12 |
| Head & Neck Cancer Alliance Inc | Charleston | 501(c)(3) | 2013 | $1.5 million | $2.7 million | 2025-12 |
| Lions Vision Services A South Carolina Charity | Columbia | 501(c)(3) | 1971 | $1.4 million | $2.8 million | 2025-06 |
| James R Clark Memorial Sickle Cell Foundation Inc | Columbia | 501(c)(3) | 1989 | $1.3 million | $585,856 | 2024-12 |
| Chrysalis Autism Center Inc | Rock Hill | 501(c)(3) | 2011 | $1.1 million | $429,867 | 2024-12 |
| Beautiful Gate Center | N Charleston | 501(c)(3) | 2016 | $1.1 million | $329,261 | 2025-06 |
| Pledge the Pink Foundation | Bluffton | 501(c)(3) | 2011 | $1.1 million | $198,205 | 2025-12 |
| Cancer Association of Anderson | Anderson | 501(c)(3) | 2003 | $913,965 | $2.7 million | 2025-12 |
| Advanced Institute for Development and Learning | Greenville | 501(c)(3) | 2015 | $857,667 | $87,817 | 2023-12 |
| Cces Endowment Corporation | Greenville | 501(c)(3) | 2003 | $741,534 | $8.8 million | 2025-06 |
| Ark of SC | Summerville | 501(c)(3) | 2015 | $739,442 | $649,869 | 2025-12 |
| Joyful Journeys Inc | Bluffton | 501(c)(3) | 2022 | $666,429 | $320,632 | 2025-12 |
| North Charleston Dental Outreach | N Charleston | 501(c)(3) | 2016 | $619,128 | $1.2 million | 2025-12 |
| Nothing Pink Inc | Fort Mill | 501(c)(3) | 2016 | $574,757 | $291,372 | 2025-12 |
| Abvi Foundation | Charleston | 501(c)(3) | 2024 | $493,609 | $5.8 million | 2025-06 |
| Beginnings for Parents of Children Who Are Deaf Or Hard of Hearing-Sc | West Columbia | 501(c)(3) | 2014 | $417,515 | $95,037 | 2026-06 |
| Neuroendocrine Cancer Awareness Network Inc | Fort Mill | 501(c)(3) | 2004 | $405,089 | $108,964 | 2024-12 |
| Lowcountry Autism Foundation Inc | Bluffton | 501(c)(3) | 2008 | $357,255 | $91,151 | 2024-12 |
| Servants for Sight | Greenville | 501(c)(3) | 2010 | $353,090 | $793,966 | 2024-12 |
| Louvenia D Barksdale Sickle Cell Anemia Foundation Inc | Spartanburg | 501(c)(3) | 1984 | $298,707 | $76,850 | 2024-12 |
| National Federation of the Blind of South Carolina | Columbia | 501(c)(3) | 1970 | $283,721 | $150,857 | 2025-12 |
| National Federation of the Blind of South Carolina | Columbia | 501(c)(3) | 1970 | $283,721 | $150,857 | 2025-12 |
| Team Sammie Breast Cancer Foundation Inc | Simpsonville | 501(c)(3) | 2025 | $259,066 | $7,347 | 2025-12 |
| Dragon Boat Charleston | Charleston | 501(c)(3) | 2009 | $235,377 | $275,071 | 2025-09 |
| Carolina Childrens Charity Inc | Charleston | 501(c)(3) | 1989 | $227,330 | $699,334 | 2025-09 |
| Cancer of Many Colors Inc | Lexington | 501(c)(3) | 2014 | $208,258 | $305,243 | 2024-12 |
| Committee On Better Racial Assurance | N Charleston | 501(c)(3) | 1973 | $198,039 | $357,486 | 2025-06 |
| Duke Arthroplasty Society Inc | Irmo | 501(c)(3) | 2025 | $189,552 | $69,214 | 2025-12 |
| Calhoun Traumatic Brain Injury Foundation | Columbia | 501(c)(3) | 2025 | $186,262 | $164,199 | 2025-12 |
| Battle Buddies | Piedmont | 501(c)(3) | 2014 | $180,385 | $16,223 | 2024-12 |
| Gi Nutrition Foundation | Mt Pleasant | 501(c)(3) | 2019 | $173,750 | $162,104 | 2025-12 |
| South Carolina Rheumatism Society | Summerville | 501(c)(3) | 2014 | $169,238 | $228,483 | 2025-12 |
| Rock the Block | Charleston | 501(c)(3) | 2021 | $168,421 | $92,381 | 2025-12 |
| Fighting To Win Inc | Beech Island | 501(c)(3) | 2015 | $168,153 | $443,383 | 2024-12 |
| A Steady Hand Foundation Inc | Summerville | 501(c)(3) | 2021 | $163,994 | $22,605 | 2025-12 |
| Champion Autism Network | Surfside BCH | 501(c)(3) | 2016 | $160,587 | $25,935 | 2025-12 |
| Trailhead Community Farm School | Travelers RST | 501(c)(3) | 2023 | $148,256 | $17,626 | 2025-06 |
| South Carolina Neurological Association | Columbia | 501(c)(3) | 2008 | $134,600 | $190,067 | 2025-12 |
| Friends of the York County Library | Rock Hill | 501(c)(3) | 2011 | $133,020 | $158,276 | 2025-12 |
| Happy Wheels Inc | Lexington | 501(c)(3) | 2012 | $128,281 | $184,020 | 2025-12 |
| Operation Sight | Mt Pleasant | 501(c)(3) | 2012 | $124,341 | $59,731 | 2025-06 |
| South Carolina Society for Respiratory Care | Columbia | 501(c)(6) | 1971 | $113,491 | $109,837 | 2025-12 |
| All 4 Autism | Florence | 501(c)(3) | 2014 | $109,609 | $67,790 | 2025-06 |
| Orangeburg Area Sickle Cell Anemia Foundation | Orangeburg | 501(c)(3) | 2004 | $107,986 | $57,680 | 2025-06 |
| Annual SC Hiv-Std Conference | Columbia | 501(c)(3) | 2021 | $101,290 | $200,738 | 2025-12 |
| Walk for Autism - Charleston | N Charleston | 501(c)(3) | 2008 | $92,677 | $103,263 | 2025-05 |
| The B Strong Group | Columbia | 501(c)(3) | 2024 | $91,835 | $1,000 | 2025-12 |
| South Carolina Ovarian Cancer Foundation | Greenville | 501(c)(3) | 2000 | $91,726 | $460,301 | 2024-12 |
| Hope Helping Others Progress Through Education | Rock Hill | 501(c)(3) | 2014 | $75,950 | $0 | 2025-12 |
| Pickles People Inc | Charleston | 501(c)(3) | 2021 | $72,755 | $74,475 | 2024-12 |
| Be the Change Charleston Inc | Charleston | 501(c)(3) | 2019 | $72,718 | $15,126 | 2025-12 |
| Canhope | Aiken | 501(c)(3) | 2004 | $72,111 | $106,409 | 2025-12 |
| Sma-Pme Research | Myrtle Beach | 501(c)(3) | 2022 | $70,455 | $53,225 | 2025-12 |
| Partnership for Proactive Health Inc | Kiawah Island | 501(c)(3) | 2022 | $63,464 | $459,464 | 2025-12 |
| Diann Shaddox Foundation | Aiken | 501(c)(3) | 2014 | $61,793 | $15,051 | 2024-12 |
| Grand Strand Down Syndrome Society | Myrtle Beach | 501(c)(3) | 2007 | $56,813 | $90,308 | 2025-12 |
| Salem Lions Charities Inc | Salem | 501(c)(3) | 1995 | $53,010 | $73,403 | 2025-06 |
| Lowcountry Ovarian Cancer Alliance | Daniel Island | 501(c)(3) | 2024 | $50,178 | $79,100 | 2025-12 |
| Friends of Ithemba | Ninety Six | 501(c)(3) | 2005 | $45,540 | $45,641 | 2025-12 |
| South Carolina Youth Diabetes Association | Heath Springs | 501(c)(3) | 2014 | $44,184 | $110,636 | 2024-12 |
| Akanimo Cancer Foundation | Greer | 501(c)(3) | 2022 | $39,756 | $1 | 2024-12 |
| Hoops Fight Als | Columbia | 501(c)(3) | 2019 | $35,217 | $1 | 2025-09 |
| Bella Muntean-Angel Heart of Hope Charity Inc | Greer | 501(c)(3) | 2019 | $34,392 | $69,977 | 2025-12 |
| Cystic Fibrosis Bites | Mt Pleasant | 501(c)(3) | 2026 | $32,958 | $6,994 | 2025-12 |
| Ovarian Cancer Coalition of Central South Carolina | West Columbia | 501(c)(3) | 2013 | $14,989 | $9,362 | 2025-12 |
| Commonwealth Cares Foundation | Daniel Island | 501(c)(3) | 2008 | $10,006 | $6,022 | 2025-12 |
| Mod Dental Aesthetics | Charleston | 501(c)(3) | 2023 | $8,000 | $211,425 | 2025-12 |
| For the Win Inc | Bluffton | 501(c)(3) | 2016 | $7,102 | $21,325 | 2025-12 |
| Sickle Cell Lights of Hope | Belton | 501(c)(3) | 2022 | $5,625 | $7,996 | 2024-12 |
| Jeremiah Henry Kendrick Memorial Foundation | Goose Creek | 501(c)(3) | 2024 | $2,567 | $8,649 | 2024-12 |
| Aura Cares | Summerville | 501(c)(3) | 2023 | $1,300 | $275 | 2023-12 |
| Share A Smile People Helping People | Columbia | 501(c)(3) | 2015 | $700 | $35,389 | 2025-12 |
| A Greatful Heart | Summerville | 501(c)(3) | 2023 | $0 | $0 | 2024-06 |
| Abbys Friends | Charleston | 501(c)(3) | 2007 | $0 | $49,242 | 2024-12 |
| Addies All-Stars | Effingham | 501(c)(3) | 2019 | $0 | $0 | 2024-06 |
| Adult Spectrum Transitions | Camden | 501(c)(3) | 2020 | $0 | $0 | 2025-12 |
| Americas Association of Sarcoidosis and Granulomatous Disorders | Charleston | 501(c)(3) | 2026 | |||
| Anchored By Faith Cancer Foundation | Summerville | 501(c)(3) | 2024 | $0 | $0 | 2025-12 |
| Ausism Today | Williamston | 501(c)(3) | 2025 | |||
| Behr Down Foundation | Boiling SPGS | 501(c)(3) | 2019 | $0 | $0 | 2025-12 |
| Brazilian Health Equity Foundation | Charleston | 501(c)(3) | 2022 | $0 | $0 | 2025-12 |
| Bridging the Gap Society for Autism | Summerville | 501(c)(3) | 2026 | |||
| Broken Wing Farm | Honea Path | 501(c)(3) | 2013 | $0 | $146 | 2023-12 |
| Camdens Cause | Fort Mill | 501(c)(3) | 2026 | |||
| Caring Fore Coby | Summerville | 501(c)(3) | 2022 | $0 | $0 | 2023-12 |
| Carla Rose Foundation Inc | Roebuck | 501(c)(3) | 2014 | $0 | $0 | 2025-12 |
| Carmeline Del Vecchio Memorial Foundation | Hardeeville | 501(c)(3) | 2014 | $0 | $0 | 2025-12 |
| Carolina Diabetes and Kidney Foundation | Sumter | 501(c)(3) | 2009 | $2 million | 2025-12 | |
| Carolina Empowerment Group | N Charleston | 501(c)(3) | 2007 | $0 | $0 | 2024-12 |
| Cars for the Cure | Simpsonville | 501(c)(3) | 2020 | $0 | $0 | 2025-06 |
| Casa Upstate SC Inc | Easley | 501(c)(3) | 2024 | $0 | $0 | 2025-12 |
| Chasing Butterflies | Cheraw | 501(c)(3) | 2024 | $0 | $0 | 2025-12 |
| Chesterfield County Treasure Shop | Cheraw | 501(c)(3) | 2026 | |||
| Clap Your Hands | Summerville | 501(c)(3) | 2014 | $0 | $0 | 2025-12 |
| Columbia Parkinsons Support Group | Columbia | 501(c)(3) | 2013 | $0 | $0 | 2025-12 |
| Comfort Cause | Pickens | 501(c)(3) | 2024 | |||
| Community Health Assistance Team | Columbia | 501(c)(3) | 2007 | $0 | $0 | 2024-12 |
| Complimentary Cancer Care Inc | Myrtle Beach | 501(c)(3) | 2008 | |||
| Cotter Cares Foundation | Fort Mill | 501(c)(3) | 2025 | $0 | $0 | 2025-05 |
| Courage for Kids | Spartanburg | 501(c)(3) | 2026 | |||
| Crowning Lupus | Aiken | 501(c)(3) | 2015 | $0 | $0 | 2025-12 |
| Day By Day Foundation | Townville | 501(c)(3) | 2015 | $0 | $0 | 2025-12 |
| Delaneys Drive for Smiles | Myrtle Beach | 501(c)(3) | 2026 | |||
| Down Syndrome Families of the Midlands | Lexington | 501(c)(3) | 2023 | $0 | $0 | 2025-12 |
| Edisto Belles | Edisto Island | 501(c)(3) | 2015 | $0 | $0 | 2023-12 |
| Epilepsy Life Source Awareness | Hopkins | 501(c)(3) | 2026 | |||
| Every Shot Counts the Bobby Brennick Memorial Fund | Summerville | 501(c)(3) | 2023 | $0 | $0 | 2025-12 |
| Extracelluar Matrix Research Foundation | Hilton Head | 501(c)(3) | 2019 | $0 | $0 | 2025-12 |
| Georgetown County Diabetes Core Group | Georgetown | 501(c)(3) | 2006 | $0 | $0 | 2025-12 |
| Georgia Perinatal Association Inc | North Augusta | 501(c)(3) | 2018 | $0 | $0 | 2025-12 |
| Gift of Life National Kidney Foundation | Darlington | 501(c)(3) | 2025 | |||
| Gifts From the Heart | Myrtle Beach | 501(c)(3) | 2019 | $0 | $0 | 2025-12 |
| Golden Corner Respite Care Program | Seneca | 501(c)(3) | 2016 | $0 | $0 | 2024-12 |
| Got Results Inc | Winnsboro | 501(c)(3) | 2021 | $0 | $0 | 2025-12 |
| Guardian Research Network Inc | Spartanburg | 501(c)(3) | 2017 | $7.1 million | 2025-09 | |
| Hannahs Hope Ministries Inc | Roebuck | 501(c)(3) | 2007 | $0 | $0 | 2024-12 |
| Hapc Virtual Didactics Inc | Columbia | 501(c)(3) | 2024 | |||
| Hardyhandz Foundation | Columbia | 501(c)(3) | 2020 | $0 | $0 | 2025-12 |
| Hart2hart Breast Cancer Awareness Organization | Rock Hill | 501(c)(3) | 2025 | $0 | $0 | 2025-12 |
| Head and Neck Hope Foundation | Charleston | 501(c)(3) | 2026 | |||
| Health Bridge Charity of South Caro Lina Inc | Sumter | 501(c)(3) | 2026 | |||
| Heart of Gold Autism Foundation | Lancaster | 501(c)(3) | 2026 | |||
| Helping Hands 843 | Lake City | 501(c)(3) | 2024 | |||
| Hemangioma Treatment Foundation Inc | Charleston | 501(c)(3) | 2003 | $0 | $8,172 | 2024-12 |
| Honest Hope Outreach Nurtures Empow Erment Supporting Trust | Fairfax | 501(c)(3) | 2026 | |||
| Hope Chest | Georgetown | 501(c)(3) | 2025 | |||
| Hope for Hollis- Epilepsy Research & Awareness | Hopkins | 501(c)(3) | 2019 | $0 | $0 | 2025-09 |
| Inspired Hope Now | Summerville | 501(c)(3) | 2022 | $0 | $0 | 2025-06 |
| JC Stroble Glaucoma Foundation | Spartanburg | 501(c)(3) | 2009 | $0 | $0 | 2025-12 |
| Jesses Wish | Bluffton | 501(c)(3) | 2016 | $0 | $0 | 2025-12 |
| Johnson Rare Love Foundation | Fort Mill | 501(c)(3) | 2025 | |||
| Judds Legacy Icp Awareness | Union | 501(c)(3) | 2020 | $0 | $0 | 2025-12 |
| Kamdyns Light From Heaven | Inman | 501(c)(3) | 2026 | |||
| Klub Lift Inc | Greenville | 501(c)(3) | 2022 | $0 | $0 | 2024-12 |
| Lady Bugs Across America Inc | Greenville | 501(c)(3) | 2015 | $0 | $0 | 2025-12 |
| Latin America Leukemia Net Lalnet | North Augusta | 501(c)(3) | 2010 | $0 | $0 | 2024-12 |
| Love for Therapeutic Riding | Beaufort | 501(c)(3) | 2010 | $0 | $0 | 2025-12 |
| Maiken A Difference Lbda Support Group | Summerville | 501(c)(3) | 2016 | $0 | $0 | 2025-12 |
| Man Cancer Foundation | Summerville | 501(c)(3) | 2026 | |||
| Medical Mission Ecuador USA | Columbia | 501(c)(3) | 2026 | |||
| Moms On Mission for A Cure | Mt Pleasant | 501(c)(3) | 2019 | $0 | $0 | 2026-04 |
| Montrels Mini Heartbeats | Moncks Corner | 501(c)(3) | 2024 | $0 | $1 | 2024-12 |
| Network of Arab American Surgeons | Charleston | 501(c)(3) | 2026 | |||
| Neuro Navigators Support and Advocacy Group | Bluffton | 501(c)(3) | 2024 | $0 | $0 | 2025-12 |
| No More Cancer Inc | Greenville | 501(c)(3) | 2011 | $0 | $0 | 2025-12 |
| Odd Kidneys | Fort Mill | 501(c)(3) | 2021 | $0 | $0 | 2025-12 |
| Oncology101org | Greenwood | 501(c)(3) | 2026 | |||
| PG Care Foundation | Fort Mill | 501(c)(3) | 2022 | $0 | $0 | 2024-12 |
| Pathways SC | Lexington | 501(c)(3) | 2026 | |||
| Patricia H Williams Foundation | Lake Wylie | 501(c)(3) | 2013 | $0 | $0 | 2025-12 |
| Piedmont Speech and Hearing Consort | Greenville | 501(c)(3) | 2013 | $0 | $5,781 | 2024-12 |
| Post Pink Power | Smyrna | 501(c)(3) | 2026 | |||
| Premier Neurology Foundation Inc | Taylors | 501(c)(3) | 2023 | $0 | $0 | 2025-12 |
| Puzzle Piece Foundation Inc | Seneca | 501(c)(3) | 2014 | $22,166 | 2024-12 | |
| RMS Family Foundation Inc | Myrtle Beach | 501(c)(3) | 2020 | $13,617 | 2024-12 | |
| Rare Disease Resources Foundation | Blythewood | 501(c)(3) | 2019 | $0 | $0 | 2025-12 |
| Rare Together Worldwide | Charleston | 501(c)(3) | 2022 | $0 | $0 | 2023-07 |
| Return To Life Foundation | Summerville | 501(c)(3) | 2012 | $0 | $0 | 2024-12 |
| Rheumakids | Myrtle Beach | 501(c)(3) | 2026 | |||
| Riley Foundation for Sickle Cell Disease | Little River | 501(c)(3) | 2023 | $0 | $0 | 2025-12 |
| Rise SC Hub for Health Access Inc | Spartanburg | 501(c)(3) | 2025 | $0 | $0 | 2024-12 |
| SC Assoc of Cardiovascular & Pulmonary Rehabilitation Inc | Columbia | 501(c)(3) | 2009 | $0 | $0 | 2025-04 |
| Savannah Kares | Mauldin | 501(c)(3) | 2017 | $0 | $0 | 2024-12 |
| Sea Kids Smile Worldwide | Bluffton | 501(c)(3) | 2022 | $0 | $0 | 2025-12 |
| Sickle Cell Is Curable | Florence | 501(c)(3) | 2025 | |||
| Sisters Still Surviving Foundation | Heath Springs | 501(c)(3) | 2026 | |||
| Smile On Cancer | Greer | 501(c)(3) | 2018 | $0 | $0 | 2024-12 |
| Smiles for Epilepsy Freedom Inc | Irmo | 501(c)(3) | 2021 | $0 | $0 | 2023-12 |
| South Carolina Association of Council On Aging Directors | Columbia | 501(c)(3) | 2021 | $0 | $0 | 2025-12 |
| Specially Equipped for Success Inc | West Columbia | 501(c)(3) | 2022 | $0 | $0 | 2023-09 |
| Starbright Network Inc | Eastover | 501(c)(3) | 2007 | $0 | $1 | 2022-12 |
| Steves Way | Seneca | 501(c)(3) | 2026 | $0 | $0 | 2025-12 |
| Sun City Strong | Indian Land | 501(c)(3) | 2019 | $0 | $0 | 2025-12 |
| Support Breath of Life Inc | Mt Pleasant | 501(c)(3) | 2014 | $0 | $0 | 2025-12 |
| Survivors Against Mental Health | Summerville | 501(c)(3) | 2024 | |||
| Taking Care of Granny | Rock Hill | 501(c)(3) | 2026 | |||
| Tbi Meets Foundation | Eutawville | 501(c)(3) | 2026 | |||
| The Pink Project | Moncks Corner | 501(c)(3) | 2025 | |||
| Thyroid Necklace Inc | Aynor | 501(c)(3) | 2014 | $0 | $0 | 2025-12 |
| Towards A Worthy Cause Inc | Conway | 501(c)(3) | 2021 | $0 | $0 | 2025-12 |
| Tracheo-Broncho-Malacia Airway Foundation Tbmaf | Chapin | 501(c)(3) | 2016 | $0 | $0 | 2024-12 |
| Travelers Rest Garden Club NFP | Taylors | 501(c)(3) | 2025 | $0 | $0 | 2025-12 |
| Trust Your Struggle | Columbia | 501(c)(3) | 2015 | $0 | $0 | 2024-12 |
| Type 1 Diabetes Life | Charleston | 501(c)(3) | 2023 | $1 | 2024-12 | |
| Upside of Downs of Aiken | Aiken | 501(c)(3) | 2011 | $0 | $0 | 2025-12 |
| Upstate Parkinsons Society | Anderson | 501(c)(3) | 2024 | $0 | $0 | 2024-12 |
| Victorious Smiles | Indian Land | 501(c)(3) | 2024 | |||
| Vtlymeorg Inc | Bluffton | 501(c)(3) | 2019 | $0 | $0 | 2024-12 |
| WMMB Awareness Inc | Manning | 501(c)(3) | 2026 | |||
| Were All Wonders | Moncks Corner | 501(c)(3) | 2023 | $0 | $0 | 2025-10 |
| Wings On Water | Summerville | 501(c)(3) | 2026 | |||
| World Change in Charity International | Columbia | 501(c)(3) | 2025 | |||
| Zions Care | Bennettsville | 501(c)(3) | 2019 | $0 | $0 | 2025-12 |
Every nonprofit in South Carolina
Read from the IRS Exempt Organizations Business Master File, updated by the IRS on October 24, 2026 and rebuilt here every morning. Revenue and assets are from each organization's latest filing as the IRS lists it; the IRS record is the official one. Organizations only: no people are named on these pages.