Data / Nonprofits / South Carolina / Animal-related
Animal-related nonprofits in South Carolina: 733 registered with the IRS
733 animal-related nonprofits are registered with the IRS in South Carolina, 725 of them 501(c)(3) charities; the 228 that report revenue took in $161.5 million. The most are in Aiken (31), Columbia (28), Greenville (27). The largest by revenue: South Carolina Aquarium ($20.3 million), Charleston Animal Society ($14.3 million), Turtle Survival Alliance ($11 million).
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The 500 largest by revenue
| Organization | City | Type | Since | Revenue | Assets | Filing |
|---|---|---|---|---|---|---|
| South Carolina Aquarium | Charleston | 501(c)(3) | 1993 | $20.3 million | $50.9 million | 2024-12 |
| Charleston Animal Society | N Charleston | 501(c)(3) | 1965 | $14.3 million | $39.4 million | 2025-12 |
| Turtle Survival Alliance | N Charleston | 501(c)(3) | 2005 | $11 million | $22 million | 2025-12 |
| South Carolina Society for the Prevention of Cruelty To Animals | Greenville | 501(c)(3) | 1949 | $9.5 million | $15.8 million | 2024-12 |
| Riverbanks Society | Columbia | 501(c)(3) | 1974 | $8 million | $7.8 million | 2025-06 |
| Pawmettolifeline Inc | Columbia | 501(c)(3) | 1999 | $7.5 million | $10.5 million | 2024-12 |
| Grand Strand Humane Society Inc | Myrtle Beach | 501(c)(3) | 1977 | $4.7 million | $5.1 million | 2025-06 |
| Darlington County Humane Society Inc | Hartsville | 501(c)(3) | 1998 | $4 million | $10.5 million | 2024-12 |
| Danny and Rons Rescue | Rembert | 501(c)(3) | 2008 | $3.9 million | $4.7 million | 2025-12 |
| Humane Society for the Prevention | Columbia | 501(c)(3) | 1967 | $3.4 million | $5.5 million | 2025-06 |
| Pet Helpers Inc | N Charleston | 501(c)(3) | 1986 | $3.4 million | $9.1 million | 2025-12 |
| Pets Inc of the Midlands | Lexington | 501(c)(3) | 1993 | $3 million | $1.8 million | 2025-12 |
| Spca Albrecht Center for Animal Welfare | Aiken | 501(c)(3) | 1952 | $2.7 million | $8.2 million | 2024-12 |
| Hilton Head Humane Association Inc | Hilton Head | 501(c)(3) | 1976 | $2.4 million | $14.7 million | 2025-12 |
| Animal Protection League of South Carolina | West Columbia | 501(c)(3) | 1983 | $2.3 million | $3.2 million | 2024-12 |
| Animal Allies | Spartanburg | 501(c)(3) | 2001 | $2.3 million | $2.6 million | 2025-12 |
| Dorchester Paws | Summerville | 501(c)(3) | 1980 | $2.2 million | $5.9 million | 2025-12 |
| International Primate Protection League | Summerville | 501(c)(3) | 1976 | $2.2 million | $10.4 million | 2024-12 |
| Roccos Hilltop Ranch Inc | Piedmont | 501(c)(3) | 2022 | $2.1 million | $1.9 million | 2025-12 |
| All 4 Paws | Pawleys Isl | 501(c)(3) | 2012 | $2.1 million | $1.5 million | 2025-12 |
| Friends of the Greenville Zoo Inc | Greenville | 501(c)(3) | 1979 | $1.7 million | $3 million | 2025-06 |
| Hallie Hill Animal Sanctuary | Hollywood | 501(c)(3) | 2023 | $1.5 million | $6.2 million | 2024-12 |
| Florence Area Humane Society | Florence | 501(c)(3) | 1974 | $1.5 million | $3.7 million | 2025-12 |
| World Parrot Trust USA Inc | Travelers RST | 501(c)(3) | 1994 | $1.4 million | $2.5 million | 2026-03 |
| York County Humane Society | Fort Mill | 501(c)(3) | 1978 | $1.4 million | $4.1 million | 2025-09 |
| Avian Conservation Center | Awendaw | 501(c)(3) | 1993 | $1.4 million | $5.9 million | 2024-12 |
| Oconee County Humane Society Inc | Seneca | 501(c)(3) | 2002 | $1.3 million | $1.8 million | 2025-06 |
| Saint Frances Animal Center | Georgetown | 501(c)(3) | 1986 | $1.3 million | $2.2 million | 2024-12 |
| Humane Society of Greenwood | Greenwood | 501(c)(3) | 1959 | $1.2 million | $1.5 million | 2025-06 |
| Carolina Poodle Rescue | Pacolet | 501(c)(3) | 2005 | $1.2 million | $730,420 | 2025-12 |
| Friends of the Animal Shelter Inc | Aiken | 501(c)(3) | 2010 | $1.1 million | $4.8 million | 2025-12 |
| Kind Keeper Inc | North Myrtle Beach | 501(c)(3) | 2014 | $1.1 million | $1.1 million | 2024-12 |
| Equine Rescue of Aiken | Aiken | 501(c)(3) | 2019 | $1.1 million | $2.1 million | 2025-12 |
| Snipwell Spay Neuter & Wellness Clinic Inc | Fort Mill | 501(c)(3) | 2018 | $1 million | $354,098 | 2025-12 |
| Kershaw County Humane Society | Camden | 501(c)(3) | 1971 | $1 million | $2 million | 2024-12 |
| Jasper Animal Rescue Mission | Ridgeland | 501(c)(3) | 2005 | $998,340 | $491,751 | 2025-06 |
| The Humane Society of North Myrtle Beach Inc | North Myrtle Beach | 501(c)(3) | 2001 | $980,651 | $1.4 million | 2024-12 |
| Last Chance Animal Rescue Fund | Carlisle | 501(c)(3) | 2010 | $871,524 | $480,157 | 2024-12 |
| Society for the Prevention of Cruelty To Animals & Humane | Sumter | 501(c)(3) | 1970 | $701,270 | $3.8 million | 2026-04 |
| Clemson Paw Partners | Central | 501(c)(3) | 2018 | $682,240 | $500,208 | 2025-12 |
| Animal Refuge Keepers Inc the Ark | North Augusta | 501(c)(3) | 2014 | $673,216 | $1.2 million | 2025-12 |
| Animal Mission | Columbia | 501(c)(3) | 1991 | $665,186 | $1.2 million | 2026-06 |
| WWW Pilotsnpaws Org Incorporated | Landrum | 501(c)(3) | 2009 | $627,108 | $4.1 million | 2025-12 |
| Noahs Arks Rescue | Okatie | 501(c)(3) | 2009 | $626,532 | $1.8 million | 2024-12 |
| South Carolina Wildlife Federation | Columbia | 501(c)(3) | 1951 | $619,465 | $977,655 | 2025-12 |
| Boykin Spaniel Rescue | Boiling SPGS | 501(c)(3) | 2001 | $581,340 | $534,863 | 2025-12 |
| A Second Chance Animal Shelter | Manning | 501(c)(3) | 2001 | $560,243 | $512,623 | 2024-12 |
| Lancaster Spca | Lancaster | 501(c)(3) | 2014 | $537,543 | $266,306 | 2024-12 |
| Animal Helpers Retail Resale Store LLC | Charleston | 501(c)(3) | 2014 | $512,374 | $99,301 | 2025-12 |
| Wildlife Action Inc | Mullins | 501(c)(3) | 1985 | $504,834 | $8.9 million | 2024-12 |
| Hollywild Animal Park Inc | Wellford | 501(c)(3) | 2000 | $488,180 | $475,633 | 2025-10 |
| Carolina Wildlife Center | Columbia | 501(c)(3) | 1991 | $467,859 | $248,665 | 2024-12 |
| Pickens County Humane Society | Liberty | 501(c)(3) | 1972 | $420,687 | $204,419 | 2024-12 |
| Humane Society of Marlboro County Inc | Bennettsville | 501(c)(3) | 2012 | $408,790 | $120,056 | 2025-07 |
| South Carolina Wildlife Partnership | Orangeburg | 501(c)(3) | 2018 | $398,393 | $65,618 | 2025-12 |
| Dog4u Inc | Camden | 501(c)(3) | 2009 | $391,894 | $839,407 | 2025-12 |
| Anderson County Humane Society Inc | Anderson | 501(c)(3) | 1975 | $390,304 | $1.1 million | 2025-12 |
| Lovable Paws Rescue | Ridgeland | 501(c)(3) | 2015 | $386,431 | $653,048 | 2025-12 |
| Concerned Citzens for Animals | Simpsonville | 501(c)(3) | 1981 | $358,082 | $4.3 million | 2024-12 |
| Speak for Animals | Greenville | 501(c)(3) | 2004 | $355,958 | $134,696 | 2024-12 |
| Friends of Colleton County Animal Shelter | Walterboro | 501(c)(3) | 2009 | $328,310 | $99,247 | 2025-06 |
| Animal Advocates | Okatie | 501(c)(3) | 2006 | $313,131 | $1.5 million | 2024-12 |
| Izzies Pond | Liberty | 501(c)(3) | 2014 | $305,458 | $137,156 | 2024-12 |
| Carolina Therapeutic Riding Inc | Columbia | 501(c)(3) | 2021 | $304,654 | $983,152 | 2024-12 |
| Servants Heart Ranch Inc | Clover | 501(c)(3) | 2022 | $284,703 | $551,350 | 2024-12 |
| Rescued in SC | Mt Pleasant | 501(c)(3) | 2020 | $271,698 | $33,233 | 2025-09 |
| Frog Song Farm Sanctuary | Hodges | 501(c)(3) | 2020 | $267,618 | $290,039 | 2024-12 |
| Paws in the Panhandle Rescue and Adoption | Lancaster | 501(c)(3) | 2010 | $262,060 | $1.4 million | 2024-12 |
| Journey Home Rescue Alliance | Charleston | 501(c)(3) | 2024 | $256,705 | $85,938 | 2025-12 |
| Mary Ann Morris Animal Society Inc | Cordova | 501(c)(3) | 2001 | $255,671 | $41,151 | 2025-06 |
| Mals Palz | Ridgeland | 501(c)(3) | 2024 | $244,983 | $208,525 | 2024-12 |
| Lowcountry Marine Mammal Network | N Charleston | 501(c)(3) | 2017 | $243,982 | $245,032 | 2025-06 |
| Blue Ridge Animal League | Beaufort | 501(c)(3) | 2022 | $242,523 | $386 | 2024-12 |
| Carolina Basset Hound Rescue Inc | Charleston | 501(c)(3) | 1999 | $236,204 | $146,478 | 2025-12 |
| Black Tie Boston Rescue Inc | Boiling SPGS | 501(c)(3) | 2013 | $235,172 | $28,079 | 2025-12 |
| Bridge Between Animal Rescue | Charleston | 501(c)(3) | 2022 | $224,240 | $5,683 | 2024-12 |
| Dusty Tails Animal Rescue | N Charleston | 501(c)(3) | 2022 | $219,241 | $55,725 | 2025-01 |
| Patter Pets Inc | Eastover | 501(c)(3) | 2007 | $219,075 | $41,088 | 2025-12 |
| For the Love of A Paw | Elloree | 501(c)(3) | 2016 | $214,152 | $227,839 | 2025-12 |
| Lucky Pup Rescue | Greenville | 501(c)(3) | 2024 | $214,040 | $10,501 | 2023-12 |
| Whiskers Animal Rescue and Sanctuary | Loris | 501(c)(3) | 2011 | $212,029 | $210,135 | 2024-12 |
| Hastys Haven Inc | Belton | 501(c)(3) | 2020 | $211,775 | $105,332 | 2025-12 |
| Almost Home Wellness Center | Aiken | 501(c)(3) | 2017 | $203,480 | $2.7 million | 2024-12 |
| Southeastern Reined Cow Horse Association | Belton | 501(c)(3) | 2025 | $202,146 | $4,507 | 2025-12 |
| Jesses Place Rescue Inc | Clover | 501(c)(3) | 2013 | $199,041 | $27,218 | 2025-12 |
| Richardson Rescue | York | 501(c)(3) | 2005 | $194,518 | $136,125 | 2024-12 |
| Dog Squad | Greenville | 501(c)(3) | 2022 | $191,186 | $53,391 | 2024-12 |
| Palmetto Paws Animal Rescue | Mt Pleasant | 501(c)(3) | 2013 | $186,381 | $876,582 | 2024-12 |
| Project Safe Pet | Lake Wylie | 501(c)(3) | 2011 | $184,078 | $66,492 | 2025-12 |
| Hoof and Paw Benevolent Society of South Carolina | Blythewood | 501(c)(3) | 2014 | $179,456 | $232,417 | 2025-12 |
| Carolina Loving Hound Rescue | Greenville | 501(c)(3) | 2018 | $176,248 | $74,383 | 2024-12 |
| Support Our Shelter Marion SC | Marion | 501(c)(3) | 2022 | $175,782 | $143,199 | 2025-12 |
| Partners in Animal Care Inc | Greenville | 501(c)(3) | 2016 | $174,152 | $360,092 | 2025-06 |
| Keeper of the Wild Wildlife Rescue and Sanctuary Inc | Walterboro | 501(c)(3) | 2001 | $173,954 | $143,136 | 2024-12 |
| Angels Among Us Rescue & Boarding | Liberty | 501(c)(3) | 2023 | $173,029 | $37,091 | 2025-12 |
| Fostering Foster Animal Rescue | Camden | 501(c)(3) | 2015 | $167,969 | $555,127 | 2025-12 |
| Avalo Cat Sanctuary | Wagener | 501(c)(3) | 2013 | $167,054 | $151,733 | 2024-12 |
| Cotton Branch Farm | Leesville | 501(c)(3) | 2024 | $166,731 | $10,172 | 2023-12 |
| Because of Roscoe | Columbia | 501(c)(3) | 2023 | $163,046 | $120,332 | 2025-12 |
| American Saddlebred Association of the Carolinas Inc | Aiken | 501(c)(3) | 2022 | $162,263 | $192,437 | 2025-12 |
| Miss Dixies Kitten Rescue | Seneca | 501(c)(3) | 2019 | $160,281 | $128,165 | 2024-12 |
| Cat Around Town Project | Camden | 501(c)(3) | 2016 | $151,709 | $39,644 | 2024-12 |
| P3 Animal Assistance Foundation | Landrum | 501(c)(3) | 2016 | $150,048 | $156,097 | 2025-12 |
| Paws Animal Wildlife Santuary Inc | Waterloo | 501(c)(3) | 2006 | $149,861 | $1 | 2025-12 |
| NWTF Foundation | Edgefield | 501(c)(3) | 2013 | $149,037 | $551,005 | 2024-08 |
| Hope Acres Rescue | Bonneau | 501(c)(3) | 2011 | $147,143 | $388,588 | 2025-12 |
| Sav-R-Cats International Inc | Surfside BCH | 501(c)(3) | 2003 | $146,459 | $306,968 | 2024-12 |
| Saving Sumters Strays Incorporated | Sumter | 501(c)(3) | 2017 | $146,068 | $335,541 | 2025-12 |
| Pet Tender Angels Rescue and Rehabilitation | Landrum | 501(c)(3) | 2024 | $144,484 | $369,161 | 2025-12 |
| Tibetan Terrier Health and Welfare Foundation | Hilton Head | 501(c)(3) | 2007 | $142,604 | $312,431 | 2025-12 |
| Big Oaks Rescue Farm | Hodges | 501(c)(3) | 2014 | $139,448 | $14,534 | 2025-12 |
| Southern Paw Partners | West Columbia | 501(c)(3) | 2015 | $139,248 | $55,732 | 2025-12 |
| Southern Tails for Precious Paws Rescue | Johns Island | 501(c)(3) | 2018 | $137,009 | $5,207 | 2025-12 |
| Small But Mighty Dog Rescue | Campobello | 501(c)(3) | 2020 | $133,282 | $30,066 | 2025-12 |
| Saving Huey Foundation | Edgefield | 501(c)(3) | 2016 | $123,050 | $134,959 | 2025-12 |
| Greater Columbia Obedience Club Inc | Columbia | 501(c)(7) | 2025 | $116,544 | $116,670 | 2025-12 |
| Newberry County Humane Society Inc Center | Newberry | 501(c)(3) | 2014 | $114,732 | $160,549 | 2025-12 |
| Meowdog Animal Rescue Inc | Mt Pleasant | 501(c)(3) | 2023 | $113,652 | $47,111 | 2025-12 |
| Boykin Spaniel Foundation | Rembert | 501(c)(3) | 1997 | $110,608 | $1.2 million | 2025-09 |
| Grateful Goldens Rescue of the Low Country | Myrtle Beach | 501(c)(3) | 2004 | $109,820 | $231,044 | 2025-12 |
| Low Country Dog Agility of Greater Charleston SC Inc | Charleston | 501(c)(3) | 2015 | $109,344 | $379,142 | 2025-12 |
| Coastal Animal Rescue | Murrells Inlt | 501(c)(3) | 2005 | $108,352 | $104,247 | 2024-12 |
| Maude Schiffley Chapter S P C A | Orangeburg | 501(c)(3) | 1989 | $106,291 | $45,949 | 2025-06 |
| English Setter Association of America Inc | Aiken | 501(c)(4) | 2009 | $105,735 | $278,930 | 2022-12 |
| Carolina Coonhound Rescue | Charleston | 501(c)(3) | 2014 | $105,030 | $51,738 | 2025-05 |
| Animal Lovers of Edisto Canine Rescue | Edisto Island | 501(c)(3) | 2014 | $104,966 | $268,735 | 2024-12 |
| Tidal Paws Animal Rescue | Myrtle Beach | 501(c)(3) | 2025 | $104,091 | $21,090 | 2025-12 |
| Sebastians Second Chance Cat Rescue | West Columbia | 501(c)(3) | 2024 | $101,237 | $1 | 2025-12 |
| Livestock and Equine Awareness and Rescue Network | Ravenel | 501(c)(3) | 2010 | $99,635 | $23,015 | 2024-12 |
| Foothills Golden Retriver Rescue Inc | Greenville | 501(c)(3) | 2001 | $96,334 | $213,737 | 2025-12 |
| Day Before the Rainbow Rescue Adoption and Transport Inc | Taylors | 501(c)(3) | 2015 | $96,321 | $2,926 | 2024-12 |
| Feline Lifeline Inc | Lyman | 501(c)(3) | 2011 | $94,896 | $33,228 | 2025-12 |
| Pet Haven of South Carolina | Greenville | 501(c)(3) | 2008 | $93,246 | $18,186 | 2025-12 |
| Homeward Bound Pet Rescue | Winnsboro | 501(c)(3) | 2010 | $93,151 | $43,942 | 2024-12 |
| Friends of North Augusta Animals | North Augusta | 501(c)(3) | 2017 | $92,260 | $76,281 | 2025-12 |
| All About Cats | Hilton Head Island | 501(c)(3) | 2014 | $90,099 | $90,177 | 2025-12 |
| Petatet Rescue Group Corp | Hilton Head | 501(c)(3) | 2020 | $89,938 | $31,568 | 2024-12 |
| Stone Soup Animal Rescue Inc | Woodruff | 501(c)(3) | 2020 | $89,835 | $143,967 | 2024-12 |
| M Lyons Trust Uw for Aiken County Spca | Aiken | 501(c)(3) | 1999 | $85,232 | $834,699 | 2026-05 |
| Friends of Berkeley County Animals | Goose Creek | 501(c)(3) | 2019 | $84,317 | $117,628 | 2024-12 |
| Golden Years Sanctuary | Cottageville | 501(c)(3) | 2023 | $82,750 | $142,012 | 2025-12 |
| Libby and Maces Place Animal Rescue | McClellanvle | 501(c)(3) | 2020 | $81,747 | $84,758 | 2025-12 |
| Greenville Zoo Educational Foundation Inc | Greenville | 501(c)(3) | 1997 | $80,997 | $1 million | 2025-06 |
| Lo Ve Pet Clinic Inc | Little River | 501(c)(3) | 2014 | $80,128 | $21,368 | 2025-12 |
| Paws 4 Adoption | Columbia | 501(c)(3) | 2023 | $78,498 | $10,066 | 2025-12 |
| Lowcountry Animal Rescue | Ladson | 501(c)(3) | 2003 | $74,701 | $43,345 | 2024-12 |
| Friends of York County Animal Shelter | York | 501(c)(3) | 2013 | $72,686 | $43,205 | 2026-02 |
| Fur Ever Home Cat Sanctuary | Loris | 501(c)(3) | 2022 | $68,187 | $298,317 | 2025-12 |
| Mankind Advocates No-Kill Excellence | Lyman | 501(c)(3) | 2014 | $67,525 | $67,788 | 2025-12 |
| Waters Edge Great Dane Rescue Inc | Bonneau | 501(c)(3) | 2015 | $67,232 | $7,095 | 2025-12 |
| Rabbit Sanctuary Inc | Simpsonville | 501(c)(3) | 2006 | $66,158 | $942,806 | 2025-12 |
| Shelter Rescue Project Inc | Aiken | 501(c)(3) | 2014 | $66,025 | $27,691 | 2024-12 |
| Big Paws Canine Foundation Inc | Aynor | 501(c)(3) | 2014 | $64,977 | $70,947 | 2025-12 |
| Parrot Posse | Wadmalaw Is | 501(c)(3) | 2017 | $63,014 | $23,681 | 2025-12 |
| South Carolina Animal Care and Control Association Inc | Columbia | 501(c)(3) | 2011 | $62,982 | $84,281 | 2025-12 |
| Forgotten Paws of the South | Moncks Corner | 501(c)(3) | 2024 | $62,590 | $25,853 | 2025-12 |
| Fixing the Unbroken | Anderson | 501(c)(3) | 2023 | $62,307 | $1 | 2025-12 |
| Ozzie To the Rescue | Catawba | 501(c)(3) | 2016 | $62,150 | $7,369 | 2025-12 |
| Opossum Pouch Rescue and Rehabilitation | Prosperity | 501(c)(3) | 2017 | $61,224 | $178,519 | 2024-12 |
| Michelles Rescue Tails | Conway | 501(c)(3) | 2023 | $58,751 | $2,354 | 2024-12 |
| Grand Strand Golden Retriever Rescue | Murrells Inlt | 501(c)(3) | 2013 | $57,891 | $8,673 | 2025-12 |
| Blue Moon Eclipse Aftercare Inc | North Augusta | 501(c)(3) | 2023 | $57,564 | $23,316 | 2025-12 |
| Hangry S Hideout Corp | Cottageville | 501(c)(3) | 2024 | $56,403 | $9,571 | 2025-12 |
| Shelter Volunteer Network Inc | Prosperity | 501(c)(3) | 2023 | $54,734 | $49,534 | 2025-12 |
| Pawsitively Orangeburg | Orangeburg | 501(c)(3) | 2023 | $54,513 | $15,684 | 2025-12 |
| Feral Cat Helpers Inc | Isle of Palms | 501(c)(3) | 2017 | $53,513 | $1,923 | 2025-08 |
| Kitty Claws Rescue Group SC | N Myrtle BCH | 501(c)(3) | 2019 | $52,244 | $53,337 | 2024-12 |
| Southern Paws Animal Rescue | Mt Pleasant | 501(c)(3) | 2017 | $52,180 | $9,114 | 2025-12 |
| Lowcountry Lab Rescue | Charleston | 501(c)(3) | 2004 | $51,804 | $13,180 | 2024-12 |
| Auction for A Kaws | Greenville | 501(c)(3) | 2018 | $51,582 | $14,789 | 2024-12 |
| Wild Pines Sanctuary | Union | 501(c)(3) | 2021 | $50,783 | $4,781 | 2025-12 |
| Crossroads Animal Rescue | Seneca | 501(c)(3) | 2014 | $50,427 | $185 | 2025-12 |
| Second Chance Sanctuary | Saint Stephen | 501(c)(3) | 2025 | $50,244 | $18,749 | 2026-01 |
| Feral Cat Solutions of Chapin Inc | Chapin | 501(c)(3) | 2015 | $50,152 | $19,177 | 2025-12 |
| Geraci Zoo | Mt Pleasant | 501(c)(3) | 2022 | $48,838 | $1,866 | 2024-12 |
| Scottish Terrier Rescue of the Southeast | Campobello | 501(c)(3) | 2013 | $48,696 | $235,344 | 2025-12 |
| Hub City Animal Project Inc | Spartanburg | 501(c)(3) | 2018 | $48,377 | $36,991 | 2025-12 |
| Pawsitively Rescued | Myrtle Beach | 501(c)(3) | 2025 | $47,665 | $26,718 | 2025-12 |
| Saving Animals Southern Style | Elloree | 501(c)(3) | 2020 | $45,744 | $8,809 | 2024-12 |
| Wildlife Rehab of Greenville | Greenville | 501(c)(3) | 1994 | $45,670 | $79,114 | 2025-12 |
| Humane Society of Cherokee County | Gaffney | 501(c)(3) | 2002 | $44,576 | $43,307 | 2025-12 |
| Animals First Rescue of the Carolinas Inc | Indian Land | 501(c)(3) | 2013 | $44,207 | $33,125 | 2025-12 |
| Westie Rescue Southeast | Sumter | 501(c)(3) | 2019 | $43,839 | $19,301 | 2025-12 |
| Meadow Hill Farm Rescue and Sanctuary | York | 501(c)(3) | 2022 | $43,836 | $437 | 2024-12 |
| Catnip Cats and Kittens | Ridgeway | 501(c)(3) | 2005 | $42,460 | $257,335 | 2025-12 |
| Mollys Militia Inc | North Augusta | 501(c)(3) | 2001 | $39,443 | $199,778 | 2025-04 |
| Carmens Rescue | Simpsonville | 501(c)(3) | 2014 | $37,816 | $20,402 | 2025-12 |
| Operation Care Carolina Animal Rescue Effort | Rock Hill | 501(c)(3) | 2002 | $36,583 | $293 | 2025-06 |
| Willows Run Animal Sanctuary | Blacksburg | 501(c)(3) | 2025 | $35,232 | $736 | 2025-12 |
| Deans Dogs | Columbia | 501(c)(3) | 2024 | $35,166 | $12,962 | 2024-12 |
| Greenville Humane Society Endowment | Greenville | 501(c)(3) | 2023 | $33,308 | $1.1 million | 2024-12 |
| Humane Net Inc | N Charleston | 501(c)(3) | 2001 | $33,223 | $70,697 | 2024-12 |
| Safe Haven 4 Cats SC | Conway | 501(c)(3) | 2015 | $31,182 | $10,930 | 2022-12 |
| Greyhound Crossroads | Greenwood | 501(c)(3) | 2004 | $30,348 | $28,753 | 2024-12 |
| Charleston Carriage Horse Advocates | Charleston | 501(c)(3) | 2017 | $28,590 | $227 | 2024-12 |
| Safe Haven & Educational Adventures | Greenville | 501(c)(3) | 2008 | $27,837 | $7,573 | 2025-12 |
| Upstate Animal Rescue Foundation of South Carolina | Townville | 501(c)(3) | 2008 | $25,221 | $2,000 | 2024-12 |
| New Hope Equine | Aiken | 501(c)(3) | 2013 | $25,000 | $273,965 | 2025-09 |
| Dogwood Acres Senior Dog Rescue | Leesville | 501(c)(3) | 2022 | $23,095 | $1,338 | 2025-12 |
| Shelter Animals Advocates | Graniteville | 501(c)(3) | 2016 | $23,044 | $12,194 | 2025-12 |
| Camp Winnie Inc | Clover | 501(c)(3) | 2024 | $21,741 | $1,377 | 2025-12 |
| Rogue Rescue & Sanctuary | Allendale | 501(c)(3) | 2014 | $20,222 | $51,752 | 2025-12 |
| Feline Victory Rescue Inc | Columbia | 501(c)(3) | 2015 | $19,764 | $3,172 | 2024-12 |
| Animal Rescue Fund of South Carolina | Seneca | 501(c)(3) | 2004 | $18,563 | $87,762 | 2024-12 |
| Bartlett House Feline Shelter | Eastover | 501(c)(3) | 2023 | $17,725 | $8,576 | 2025-12 |
| Second Chance of Orangeburg Animal Rescue Coalition | Orangeburg | 501(c)(3) | 2014 | $17,361 | $3,198 | 2024-12 |
| Knights in Shining Armor Rescue & Sanctuary | Walhalla | 501(c)(3) | 2020 | $15,592 | $1,429 | 2024-12 |
| Forgotten Tails Animal Rescue Inc | Manning | 501(c)(3) | 2015 | $15,000 | $46,455 | 2025-12 |
| Lamina Foundation | Townville | 501(c)(3) | 2023 | $14,046 | $2,016 | 2025-12 |
| Recycled Pets Inc | Rock Hill | 501(c)(3) | 2018 | $13,870 | $3,432 | 2025-12 |
| Underdog Outreach Project | Chesnee | 501(c)(3) | 2021 | $13,624 | $1,270 | 2025-12 |
| Preservation Station Inc | Myrtle Beach | 501(c)(3) | 2000 | $11,560 | $4,870 | 2024-12 |
| Owls Club International Inc | Greenwood | 501(c)(3) | 2002 | $11,345 | $293,910 | 2025-12 |
| New Beginnings Shepherd Rescue | Holly Hill | 501(c)(3) | 2009 | $10,279 | $931 | 2025-12 |
| Partners for Pets of Allendale County | Allendale | 501(c)(3) | 2010 | $9,388 | $9,568 | 2025-12 |
| Furry Friends Rescue Center | Clover | 501(c)(3) | 2012 | $9,026 | $72,575 | 2025-03 |
| Wild at Heart | Piedmont | 501(c)(3) | 2014 | $8,738 | $998 | 2025-12 |
| Happys Porch | Folly Beach | 501(c)(3) | 2018 | $6,882 | $557 | 2024-07 |
| Simply Amazing Transport Incorporated | Rock Hill | 501(c)(3) | 2023 | $5,636 | $2,536 | 2023-12 |
| Brunos Legacy | Lamar | 501(c)(3) | 2016 | $4,394 | $2,442 | 2023-12 |
| Pee Dee Wildlife Rescue | Aynor | 501(c)(3) | 2025 | $4,050 | $4,050 | 2025-12 |
| Kats Special Kneads | Sumter | 501(c)(3) | 2012 | $2,757 | $2,830 | 2025-12 |
| Carolina Greys Greyhound Adoption Inc | Lexington | 501(c)(3) | 2015 | $1,979 | $1,927 | 2024-12 |
| Humane Society of Lancaster SC | Lancaster | 501(c)(3) | 2009 | $1,536 | $2,878 | 2024-06 |
| RD Foundation | Charleston | 501(c)(3) | 2023 | $1,274 | $672 | 2025-12 |
| Paws and Claws | Chesterfield | 501(c)(3) | 1999 | $671 | $18,092 | 2025-12 |
| Chester County Animal Family | Catawba | 501(c)(3) | 2017 | $464 | $908 | 2025-12 |
| From the Heart | Mt Pleasant | 501(c)(3) | 2014 | $362 | $3,764 | 2025-12 |
| 1717 Equine Rehabilitation & Retirement | Salley | 501(c)(3) | 2021 | $0 | $0 | 2025-12 |
| 4 Legs and Paws Rescue | Conway | 501(c)(3) | 2017 | $0 | $0 | 2025-12 |
| 9 Lives Cat Rescue | Lexington | 501(c)(3) | 2022 | $0 | $0 | 2023-12 |
| A Helping Paw | Blythewood | 501(c)(3) | 2025 | $0 | $0 | 2025-12 |
| A Joshuas Journey Home Rescue | Pickens | 501(c)(3) | 2024 | $0 | $0 | 2025-12 |
| Abandoned Pet Project | Lexington | 501(c)(3) | 2025 | $0 | $0 | 2025-12 |
| Abbeville County Humane Society | Abbeville | 501(c)(3) | 1998 | $0 | $0 | 2025-12 |
| Abe S Funny Farm Animal Sanctuary | Eutawville | 501(c)(3) | 2022 | $0 | $0 | 2025-12 |
| Abes Funny Farm | Eutawville | 501(c)(3) | 2018 | $0 | $0 | 2025-12 |
| Actually Rescuing Cats | Campobello | 501(c)(3) | 2016 | $0 | $0 | 2025-12 |
| Affordable Spay Neuter of Anderson | Anderson | 501(c)(3) | 2009 | $0 | $0 | 2025-12 |
| Agility Club of Aiken County | Wagener | 501(c)(3) | 2026 | |||
| Aiken Horse Park Foundation | Aiken | 501(c)(3) | 2014 | $27.4 million | 2024-12 | |
| Aiken TNR Network | Aiken | 501(c)(3) | 2020 | $0 | $0 | 2025-12 |
| All About Animals Rescue & Transport Inc | Conway | 501(c)(3) | 2019 | $7,233 | 2025-06 | |
| All Paws On Deck | Hilton Head Island | 501(c)(3) | 2024 | $0 | $0 | 2025-12 |
| Alleycat Abode | N Charleston | 501(c)(3) | 2025 | $0 | $0 | 2025-10 |
| Almost Home Az Rescue Inc | Lake Wylie | 501(c)(3) | 2006 | $0 | $0 | 2024-12 |
| Almost Home Feline Refuge Inc | Mt Pleasant | 501(c)(3) | 2006 | $0 | $0 | 2025-12 |
| Altered Pets Project | N Charleston | 501(c)(3) | 2024 | $0 | $0 | 2025-12 |
| Always Room for One More | Williamston | 501(c)(3) | 2025 | $0 | $0 | 2025-12 |
| Amajams Beaks N Cheeks Sanctuary | Hardeeville | 501(c)(3) | 2024 | $0 | $0 | 2024-12 |
| Anderson Voices for Animals | Anderson | 501(c)(3) | 2011 | $0 | $0 | 2025-12 |
| Angel S Hope | Columbia | 501(c)(3) | 2012 | $0 | $0 | 2025-12 |
| Angelas Angels Dog Rescue | Johns Island | 501(c)(3) | 2026 | |||
| Angels for the Underdogs | Lexington | 501(c)(3) | 2025 | $0 | $0 | 2026-02 |
| Animal Guardians of South Carolina | Little River | 501(c)(3) | 2010 | $0 | $0 | 2025-12 |
| Animal Rescue Carolina | Columbia | 501(c)(3) | 2010 | $0 | $0 | 2025-12 |
| Animal Rescue and Relief Inc | Huger | 501(c)(3) | 2013 | $0 | $0 | 2025-12 |
| Animal Safe Haven | Boiling SPGS | 501(c)(3) | 2015 | $0 | $0 | 2025-12 |
| Animals Living Life | Ridgeville | 501(c)(3) | 2006 | $0 | $0 | 2025-12 |
| Apellas of New Hope | Coward | 501(c)(3) | 2014 | $0 | $0 | 2026-07 |
| Arkindra | Charleston | 501(c)(3) | 2025 | $0 | $0 | 2025-05 |
| Arm N Paw Inc | Lexington | 501(c)(3) | 2024 | $0 | $0 | 2025-12 |
| Ascending Bird Sanctuary | Plum Branch | 501(c)(3) | 2019 | $0 | $0 | 2024-12 |
| Ashleys Dream Foundation Corporation | Pinewood | 501(c)(3) | 2023 | $1 | 2024-12 | |
| Back Step Strays | Ware Shoals | 501(c)(3) | 2023 | $0 | $0 | 2024-12 |
| Barnwell County Animal Shelter Foundation | Barnwell | 501(c)(3) | 2008 | $0 | $0 | 2025-12 |
| Basset Rescue Crew Southeast Inc | Little MTN | 501(c)(3) | 2010 | $0 | $0 | 2025-12 |
| Baunji Strong Foundation | Gaffney | 501(c)(3) | 2018 | $0 | $0 | 2025-12 |
| Bee City Animal Conservancy Inc | Cottageville | 501(c)(3) | 2026 | |||
| Bikini Beach Cat Rescue | Murrells Inlet | 501(c)(3) | 2012 | $0 | $0 | 2024-12 |
| Bird Lovers Only Rescue Service | Duncan | 501(c)(3) | 2008 | $0 | $0 | 2025-12 |
| Black River Search and Rescue | Camden | 501(c)(3) | 2017 | $0 | $0 | 2026-01 |
| Blossom Animal Rescue and Kindness | N Charleston | 501(c)(3) | 2026 | |||
| Brodies Way Animal Refuge | West Columbia | 501(c)(3) | 2026 | |||
| Bruised Not Broken Animal Rescue | Greer | 501(c)(3) | 2023 | $0 | $0 | 2024-12 |
| Bugsbunnyrescue | Columbia | 501(c)(3) | 2022 | $0 | $0 | 2025-12 |
| Bully4you Rescue & Rehabilitation Inc | Warrenville | 501(c)(3) | 2016 | $0 | $0 | 2024-12 |
| Busters Buddies | Belton | 501(c)(3) | 2005 | $0 | $0 | 2025-07 |
| By the Beach Animal Rescue | Myrtle Beach | 501(c)(3) | 2026 | |||
| C Lords Angels | Nichols | 501(c)(3) | 2007 | $0 | $0 | 2025-12 |
| Callies Kennels | Olar | 501(c)(3) | 2024 | $1 | 2025-12 | |
| Canine Healing Project | Greenville | 501(c)(3) | 2017 | $0 | $0 | 2025-12 |
| Canine Hospice Animal Rescue | Aiken | 501(c)(3) | 2020 | $0 | $0 | 2024-12 |
| Canine Pawsabilities Rescue Inc | Warrenville | 501(c)(3) | 2020 | $0 | $0 | 2025-12 |
| Captains Salute | Johns Island | 501(c)(3) | 2018 | $9,064 | 2025-12 | |
| Carolina Animal Haven | Kershaw | 501(c)(3) | 2024 | $0 | $0 | 2025-12 |
| Carolina Avian Research Program | Sullivans Is | 501(c)(3) | 2020 | $0 | $0 | 2025-04 |
| Carolina Cat Conservation | North Charleston | 501(c)(3) | 2024 | $0 | $0 | 2025-12 |
| Carolina Dog Fanciers of America | Aiken | 501(c)(3) | 2022 | $4,358 | 2025-12 | |
| Carolina Dog Society of America | Aiken | 501(c)(3) | 2017 | $28,869 | 2025-12 | |
| Carolina German Shepherd Rescue Inc | Barnwell | 501(c)(3) | 2014 | $0 | $0 | 2025-12 |
| Carolina Hills Farm Animal Refuge Inc | Barnwell | 501(c)(3) | 2021 | $0 | $0 | 2024-12 |
| Carolina Kitties Rescue Inc | Florence | 501(c)(3) | 2017 | $0 | $0 | 2025-12 |
| Carolina Pit Bull Farm | Belton | 501(c)(3) | 2023 | $0 | $0 | 2025-12 |
| Carolina Wildlife Trust | Camden | 501(c)(3) | 2024 | |||
| Casa Avian Support Alliance | Myrtle Beach | 501(c)(3) | 2008 | $0 | $0 | 2025-12 |
| Casa Del Cane | Charleston | 501(c)(3) | 1999 | $0 | $0 | 2025-03 |
| Cat City Sanctuary | Gaffney | 501(c)(3) | 2018 | $1 | 2026-02 | |
| Cat Garage Rescue | Central | 501(c)(3) | 2024 | |||
| Cat Trap Depot | Spartanburg | 501(c)(3) | 2021 | $0 | $0 | 2025-12 |
| Catawba Junction Wildlife Rehabilitation & Farm Animal Rescu | Catawba | 501(c)(3) | 2020 | $0 | $0 | 2025-12 |
| Catcatcher Corner | Ridgeland | 501(c)(3) | 2025 | $0 | $0 | 2025-12 |
| Catopia Retirement Farm and Haven for Cats | Newberry | 501(c)(3) | 2018 | $0 | $0 | 2024-12 |
| Cats Best Friend | Irmo | 501(c)(3) | 2023 | $0 | $0 | 2025-12 |
| Cedar Creek Canine Rescue & Rehab | York | 501(c)(3) | 2026 | |||
| Celebrity Catwalk | Duncan | 501(c)(3) | 2016 | $0 | $0 | 2025-12 |
| Chapmans Dachshund Rescue | York | 501(c)(3) | 2018 | $0 | $0 | 2024-12 |
| Charleston Kennel Club Inc | Goose Creek | 501(c)(4) | 1970 | $0 | $0 | 2025-12 |
| Charlies Harmony Sanctuary & Farm Inc | Nesmith | 501(c)(3) | 2020 | $0 | $0 | 2025-12 |
| Chasing Tails Pet Patrol | Columbia | 501(c)(3) | 2014 | $0 | $0 | 2025-12 |
| Cheryls Ferals and Fosters | Fort Mill | 501(c)(3) | 2021 | $0 | $0 | 2025-12 |
| Chiquitins Cat Project | Anderson | 501(c)(3) | 2021 | $0 | $0 | 2025-02 |
| Chow Charmer Rescue | Lyman | 501(c)(3) | 2020 | $4,115 | 2025-12 | |
| Chucktown Bound Animal Rescue Resource | Charleston | 501(c)(3) | 2023 | $0 | $0 | 2025-12 |
| Cindy Lous Legacy Sanctuary | Moncks Corner | 501(c)(3) | 2023 | $0 | $0 | 2025-12 |
| Coastal Animal Advocates Inc | Beaufort | 501(c)(3) | 2023 | $34,461 | 2025-12 | |
| Coastal Cat Foundation | Port Royal | 501(c)(3) | 2023 | $8,449 | 2025-12 | |
| Coastal Wildlife Rehab and Rescue | Conway | 501(c)(3) | 2026 | |||
| Columbia Cats | Columbia | 501(c)(3) | 2026 | |||
| Comfort Cat Rescue | Moore | 501(c)(3) | 2025 | $0 | $1 | 2025-12 |
| Community Cat Coalition | Gaffney | 501(c)(3) | 2018 | $0 | $0 | 2025-12 |
| Community Organization Rescuing Aniamls | Abbeville | 501(c)(3) | 2020 | $0 | $0 | 2023-04 |
| Community Spay Neuter Program | Conway | 501(c)(3) | 2023 | $0 | $0 | 2025-12 |
| Companion Animal Relief and Education Project | Mt Pleasant | 501(c)(3) | 2025 | $0 | $0 | 2025-12 |
| Cookies for Kitties Inc | Mt Pleasant | 501(c)(3) | 2025 | $0 | $0 | 2025-12 |
| Country Acres Rescue | Chester | 501(c)(3) | 2025 | |||
| Crazy4chickens | Mountville | 501(c)(3) | 2026 | |||
| Creekside Farm and Equine Rescue | Fountain Inn | 501(c)(3) | 2020 | $0 | $0 | 2025-12 |
| Critter Cat Rescue | Aiken | 501(c)(3) | 2026 | |||
| Crocodile Conservation Institute Inc | Cross | 501(c)(3) | 2010 | $0 | $0 | 2025-12 |
| Csra Forgotten Souls Inc | N Augusta | 501(c)(3) | 2018 | $0 | $0 | 2025-12 |
| Cullens Archangel Rescue | Lexington | 501(c)(3) | 2007 | $0 | $0 | 2025-12 |
| D & E Farm Inc | Hartsville | 501(c)(3) | 2009 | $0 | $0 | 2025-12 |
| Daisy Girls Rescue | Donalds | 501(c)(3) | 2019 | $0 | $0 | 2024-12 |
| Dartmoor Pony Society of America Inc | Greenwood | 501(c)(3) | 2014 | $0 | $0 | 2025-12 |
| Dataw Island Feline Foundation Inc | St Helena Is | 501(c)(3) | 2011 | $0 | $0 | 2025-12 |
| Daufuskie Island Turtle Patrol | Daufuskie Is | 501(c)(3) | 2022 | $0 | $0 | 2025-12 |
| Daufuskie Marsh Tacky Society | Daufuskie Island | 501(c)(3) | 2016 | $0 | $0 | 2023-12 |
| Debs Baby Birds Bird Rescue and San Ctuary | Bennettsville | 501(c)(3) | 2026 | |||
| Deer Creek Ranch and Horse Rescue | Hartsville | 501(c)(3) | 2018 | $65,754 | 2024-12 | |
| Deer Field Farm and Market | Daufuskie Is | 501(c)(3) | 2011 | $0 | $0 | 2025-12 |
| Desperate Tails | Chappells | 501(c)(3) | 2024 | |||
| Destination Home Puppy Rescue | Fort Mill | 501(c)(3) | 2019 | $0 | $0 | 2025-12 |
| Diggy Dog Rescue | Lexington | 501(c)(3) | 2020 | $0 | $0 | 2024-12 |
| Dochas N Gra Hope and Love Rescue | Chesterfield | 501(c)(3) | 2013 | $0 | $0 | 2026-06 |
| Dog Patch Rescue | Enoree | 501(c)(3) | 2026 | |||
| Doggone Shelter Intervention | Gray Court | 501(c)(3) | 2016 | $0 | $0 | 2025-12 |
| Dore Ranch and Rescue | Kershaw | 501(c)(3) | 2023 | $0 | $0 | 2025-12 |
| Duddy Boos Safe Haven | Wagener | 501(c)(3) | 2014 | $0 | $0 | 2025-12 |
| East Cooper Pet Relief | Mt Pleasant | 501(c)(3) | 2017 | $0 | $0 | 2025-12 |
| Edisto Beach Loggerhead Turtle Project | Edisto Island | 501(c)(3) | 2023 | $0 | $0 | 2025-12 |
| Ethans Exotic Escapades | Greenwood | 501(c)(3) | 2026 | |||
| Eudora Farms Hooves for Education Foundation | Salley | 501(c)(3) | 2023 | $0 | $0 | 2025-12 |
| Every Life Matters Animal Rescue | Rock Hill | 501(c)(3) | 2016 | $0 | $0 | 2023-12 |
| Fairfield Animal Rescue | Winnsboro | 501(c)(3) | 2003 | $0 | $0 | 2025-12 |
| Faith and Hope Sanctuary | Pendleton | 501(c)(3) | 2004 | $838,970 | 2024-12 | |
| Fat Bottoms Pig Sanctuary Inc | Fair Play | 501(c)(3) | 2021 | $0 | $0 | 2025-12 |
| Featherheads Inc | Elgin | 501(c)(3) | 2004 | $1 | 2024-12 | |
| Feline Refuge | Mt Pleasant | 501(c)(3) | 1995 | $35,878 | 2024-12 | |
| Feral Cat TNR SC Corporation | Myrtle Beach | 501(c)(3) | 2022 | $0 | $580 | 2024-12 |
| Fighting for Fluffy and Fido | Greer | 501(c)(3) | 2022 | $0 | $0 | 2024-12 |
| Finleys Friends | Marion | 501(c)(3) | 2025 | |||
| First Breath Puppy Rescue | Summerville | 501(c)(3) | 2026 | |||
| Fixing the Ferals | Simpsonville | 501(c)(3) | 2025 | |||
| Flock Together Bird Rescue Inc | Windsor | 501(c)(3) | 2003 | $0 | $0 | 2023-12 |
| Flying Changes Equine Rescue | Aiken | 501(c)(3) | 2019 | $0 | $0 | 2024-12 |
| Flyway Foundation | Columbia | 501(c)(3) | 2006 | $0 | $1,794 | 2022-12 |
| Folly Beach Turtle Watch | Charleston | 501(c)(3) | 2019 | $0 | $0 | 2025-12 |
| For Pits Sake South Carolina | West Columbia | 501(c)(3) | 2025 | |||
| For the Love of Cats TNR Foundation | Central | 501(c)(3) | 2025 | $0 | $0 | 2025-12 |
| For the Love of Street Dogs | Lexington | 501(c)(3) | 2024 | $103,529 | 2024-12 | |
| For the Lovers of Street Dogs Corp | Lexington | 501(c)(3) | 2024 | $0 | $0 | 2024-12 |
| Foster Paws Rescue | Lyman | 501(c)(3) | 2019 | $0 | $0 | 2025-12 |
| Four Paws Rescue & Shelter Inc | Bradley | 501(c)(3) | 2011 | $0 | $0 | 2025-12 |
| Four Paws Rescue of Connecticut Inc | Gresham | 501(c)(3) | 2014 | $0 | $0 | 2025-12 |
| Free Them Foundation | Greer | 501(c)(3) | 2023 | $0 | $0 | 2025-06 |
| Freedom Ride Transport | Loris | 501(c)(3) | 2021 | $0 | $0 | 2025-12 |
| Freedom Rings Rescue Inc | Sumter | 501(c)(3) | 2015 | $0 | $0 | 2024-12 |
| Freedom Train Pit Stop Corporation | Anderson | 501(c)(3) | 2022 | $0 | $0 | 2024-12 |
| Friends for Paws Rehome Search & Rescue | Bluffton | 501(c)(3) | 2018 | $0 | $0 | 2025-12 |
| Friends of Carolina Animals | Kingstree | 501(c)(3) | 2025 | |||
| Friends of Carolina Sandhills National Wildlife Refuge | McBee | 501(c)(3) | 2007 | $0 | $0 | 2025-12 |
| Friends of Edgefield Animal Shelter Inc | Edgefield | 501(c)(3) | 2026 | |||
| Friends of Santee National Wildlife Refuge | Manning | 501(c)(3) | 2002 | $0 | $0 | 2025-12 |
| Friends of Save Shoebill Conservation Project | Summerville | 501(c)(3) | 2022 | $0 | $0 | 2025-12 |
| Fripp Island Deer Preservation and Wildlife Foundation Inc | Fripp Island | 501(c)(3) | 2022 | $0 | $0 | 2025-12 |
| Frisky Business Rescue | Lexington | 501(c)(3) | 2022 | $0 | $0 | 2025-12 |
| Funny Animal Rescue Farm | Cheraw | 501(c)(3) | 2024 | $0 | $0 | 2024-12 |
| Funny Farm Mustangs | Beech Island | 501(c)(3) | 2024 | |||
| Furever With Family | Batesburg | 501(c)(3) | 2024 | $0 | $0 | 2025-12 |
| Gallant Fox Rescue | Travelers RST | 501(c)(3) | 2018 | $0 | $0 | 2025-12 |
| Gela Foundation | Anderson | 501(c)(3) | 2023 | $0 | $0 | 2025-12 |
| Global 2by2 Rescue | Hilton Head | 501(c)(3) | 2023 | $0 | $0 | 2025-12 |
| Global Nest Exotic Bird Sanctuary | Eastover | 501(c)(3) | 2014 | $0 | $0 | 2025-12 |
| Glorification of Deer | Chapin | 501(c)(3) | 2021 | $0 | $0 | 2023-12 |
| Goat Daddys Animal Sanctuary | Elgin | 501(c)(3) | 2021 | $0 | $0 | 2025-12 |
| Gods Grace Horse and Animal Sanctuary | Windsor | 501(c)(3) | 2023 | $0 | $0 | 2025-12 |
| Gold Standard Rescue | Easley | 501(c)(3) | 2023 | |||
| Gordon Jones | North Augusta | 501(c)(3) | 2019 | $0 | $0 | 2024-12 |
| Grace & Glory Farms | Chester | 501(c)(3) | 2024 | |||
| Grace Farm Animal Rescue & Sanctuary | Islandton | 501(c)(3) | 2024 | $259,410 | 2024-12 | |
| Grace Farm Sanctuary LLC | Pelzer | 501(c)(3) | 2023 | $0 | $0 | 2025-12 |
| Gracies Fund | Barnwell | 501(c)(3) | 2015 | $0 | $0 | 2025-12 |
| Great Pyrenees North America Inc | Santee | 501(c)(3) | 2016 | $0 | $0 | 2025-12 |
| Great Pyrenees Rescue Southeast | Spartanburg | 501(c)(3) | 2025 | $0 | $0 | 2025-12 |
| Guardians for the Guardians | Seneca | 501(c)(3) | 2024 | $0 | $0 | 2025-12 |
| Gypsys Gait | Clover | 501(c)(3) | 2025 | |||
| Halfway To Heaven Equine Rescue | Aiken | 501(c)(3) | 2022 | $1 | 2024-12 | |
| Halfway To Heaven Mustang Rescue | Aiken | 501(c)(3) | 2026 | $7,260 | 2025-12 | |
| Halos Harbor Hound Rescue | Ravenel | 501(c)(3) | 2018 | $0 | $0 | 2025-12 |
| Hamptons Hope Sanctuary | Greer | 501(c)(3) | 2025 | $0 | $0 | 2026-03 |
| Hanahan Community Cats | Hanahan | 501(c)(3) | 2023 | $0 | $0 | 2025-12 |
| Happily Even After | Mullins | 501(c)(3) | 2023 | $0 | $0 | 2025-12 |
| Happy Dogs Rescue and Sanctuary for Senior Dogs | Pelzer | 501(c)(3) | 2018 | $0 | $0 | 2025-12 |
| Harbor Island Sea Turtle Project Inc | St Helena Is | 501(c)(3) | 2014 | $0 | $0 | 2025-12 |
| Harry R E Hampton Memorial Wildlife Foundation Inc | Beaufort | 501(c)(3) | 2022 | $0 | $0 | 2024-12 |
| Have A Puppers | Pickens | 501(c)(3) | 2025 | $0 | $0 | 2025-12 |
| Haven Paws Dog Rescue | Conway | 501(c)(3) | 2025 | $0 | $0 | 2026-04 |
| Haven at the Farm | Chapin | 501(c)(3) | 2026 | |||
| Hay Monsters Rabbit Sanctuary | Easley | 501(c)(3) | 2020 | $0 | $0 | 2025-12 |
| Head Butt Hotel | N Myrtle BCH | 501(c)(3) | 2014 | $0 | $0 | 2025-12 |
| Hearts of Valor Rescue | Greer | 501(c)(3) | 2025 | $0 | $0 | 2025-10 |
| Heartworm Project | Winnsboro | 501(c)(3) | 2008 | $0 | $0 | 2025-12 |
| Hepburn M Stroman Jr Spca Shelter Services of East Cooper | Mt Pleasant | 501(c)(3) | 2020 | $0 | $0 | 2025-12 |
| Heritage Landing | Greenville | 501(c)(3) | 2025 | $0 | $0 | 2025-12 |
| Hickory Haven Fawn Rescue | Belton | 501(c)(3) | 2020 | $0 | $0 | 2025-12 |
| Hilton Head Plantation Conservancy Foundation | Hilton Head | 501(c)(3) | 2003 | $0 | $0 | 2025-12 |
| Hoardin Huskies Inc | Sumter | 501(c)(3) | 2025 | $0 | $0 | 2021-12 |
| Hollow Creek Farm Equine and Canine Rescue Inc | Hickory Grove | 501(c)(3) | 2005 | $0 | $0 | 2025-12 |
| Hollywood Animal Charities | Hollywood | 501(c)(3) | 2019 | $0 | $1,140 | 2026-04 |
| Home Free Animal Sanctuary | Mt Pleasant | 501(c)(3) | 2026 | |||
| Homeward Bound Animal Haven Inc | Hemingway | 501(c)(3) | 2024 | $0 | $0 | 2025-12 |
| Hooves Hearts and Hope Equine Rescue and Sanctuary | Swansea | 501(c)(3) | 2022 | $0 | $0 | 2025-12 |
| Hope for Feral Hearts | Charleston | 501(c)(3) | 2026 | |||
| Hoppy Hearts SC | Chapin | 501(c)(3) | 2022 | $0 | $0 | 2025-12 |
| Hounds N Hooves | Greer | 501(c)(3) | 2024 | $0 | $0 | 2025-04 |
| Hounds of Peaceful Place Foundation | Chesnee | 501(c)(3) | 2018 | $0 | $0 | 2025-12 |
| Howies Hope for Community Cats | Myrtle Beach | 501(c)(3) | 2026 | |||
| Humane Society of Dillon County | Little Rock | 501(c)(3) | 2014 | $0 | $0 | 2025-12 |
| Humble Pig Animal Sanctuary Inc | Darlington | 501(c)(3) | 2022 | $0 | $0 | 2025-12 |
| Impyrean Animal Rescue and Sanctuary Inc | Greer | 501(c)(3) | 2022 | $0 | $0 | 2025-12 |
| In Memory Animal Sanctuary | Easley | 501(c)(3) | 2015 | $0 | $0 | 2025-12 |
| Interlaken Wildlife Foundation | Cameron | 501(c)(3) | 2022 | $6.3 million | 2024-12 | |
| Island Turtle Team Limited | Charleston | 501(c)(3) | 2025 | |||
| J M Perry Trust | Greenville | 501(c)(3) | 1982 | $644,065 | 2025-12 | |
| J2 Rescue & Rehab Inc | Una | 501(c)(3) | 2022 | $0 | $0 | 2025-12 |
| Jazzs Wayward Kitties | Lancaster | 501(c)(3) | 2021 | $0 | $0 | 2025-12 |
| Joeys Legacy Inc | Lexington | 501(c)(3) | 2018 | $0 | $0 | 2025-12 |
| Journeys Upstate Rescue | Fair Play | 501(c)(3) | 2020 | $0 | $0 | 2025-12 |
| Jtrkitties | Mount Croghan | 501(c)(3) | 2025 | |||
| Juju Wildlife Rescue Rehab and Sanctuary | Belton | 501(c)(3) | 2023 | $0 | $0 | 2025-12 |
| K95 Rescue | Simpsonville | 501(c)(3) | 2005 | $0 | $0 | 2025-12 |
| KJ Farms Animal Rescue | Aynor | 501(c)(3) | 2023 | $1 | 2025-12 | |
| Kare Team Sancturary | Longs | 501(c)(3) | 2001 | $0 | $0 | 2025-12 |
| Kat Katchers of Hodges | Hodges | 501(c)(3) | 2026 | $0 | $0 | 2025-11 |
| Keep Our Pets Food Bank | Murrells Inlt | 501(c)(3) | 2012 | $0 | $0 | 2025-12 |
| Keowee Lake Area Wildlife Sanctuary | Salem | 501(c)(3) | 2026 | |||
| Kindshark | Goose Creek | 501(c)(3) | 2024 | $0 | $0 | 2025-12 |
| Kirk & Tara King Family Foundation Inc | Sullivans Is | 501(c)(3) | 2018 | $1.3 million | 2025-12 | |
| Kits Kritters | Hemingway | 501(c)(3) | 2026 | $0 | $0 | 2025-12 |
| Kitsnkats Rescue | Easley | 501(c)(3) | 2014 | $0 | $0 | 2024-12 |
| Kitten Helpers | Mt Pleasant | 501(c)(3) | 2025 | |||
| Kitty Retirement Village | Ladson | 501(c)(3) | 2004 | $1 | 2025-12 | |
| Kittys Kitten Rescue Inc | West Union | 501(c)(3) | 2026 | |||
| Kona S Pawpulation Project | Anderson | 501(c)(3) | 2024 | $0 | $0 | 2025-06 |
| Lakelands Wildlife Sanctuary Inc | Greenwood | 501(c)(3) | 2015 | $0 | $0 | 2023-12 |
| Lakota Wildlife Center | Abbeville | 501(c)(3) | 2011 | $0 | $0 | 2025-12 |
| Lancaster Animal Shelter Supportors of Sun City | Fort Mill | 501(c)(3) | 2015 | $0 | $0 | 2025-12 |
| Larry Larry Carlton Animal Rescue Rehabilitation and You | Columbia | 501(c)(3) | 2025 | |||
| Leg Up Experience | Aiken | 501(c)(3) | 2024 | $0 | $0 | 2025-12 |
| Lily S Haven Inc | Rock Hill | 501(c)(3) | 2021 | $0 | $0 | 2025-12 |
| Little Black Dog Rescue Inc | Mt Pleasant | 501(c)(3) | 1998 | $0 | $0 | 2025-12 |
| Little Feet Haven | Rock Hill | 501(c)(3) | 2019 | $0 | $0 | 2025-12 |
| Little Muzzles Rescue Inc | Walhalla | 501(c)(3) | 2026 | |||
| Little Whiskers Rescue | Charleston | 501(c)(3) | 2026 | |||
| Lizards Second Chance | Greenville | 501(c)(3) | 2026 | |||
| Lolas House of Bostons & Rescue | Anderson | 501(c)(3) | 2021 | $0 | $0 | 2025-12 |
| Long Eared Ambassadors | Boiling SPGS | 501(c)(3) | 2024 | $0 | $0 | 2025-01 |
| Lost Mittens Rescue | Sumter | 501(c)(3) | 2026 | |||
| Lotsa Heart Animal Sanctuary Inc | Aiken | 501(c)(3) | 2022 | $0 | $0 | 2025-12 |
| Love 4 Paws Rescue | Longs | 501(c)(3) | 2023 | $0 | $0 | 2025-12 |
| Low Country Game Bird Foundation Inc | Beaufort | 501(c)(3) | 2023 | $69,965 | 2025-12 | |
| Lowcountry Chapter 1988 Inc | Summerville | 501(c)(3) | 2025 | |||
| Lowcountry Equine Rescue | Georgetown | 501(c)(3) | 2026 | |||
| Lowcountry Farm & Rescue | Ruffin | 501(c)(3) | 2023 | $0 | $0 | 2025-12 |
| Lowcountry Kitten Rescue Inc | Mt Pleasant | 501(c)(3) | 2020 | $0 | $0 | 2025-12 |
| Lowcountry Raptors | Ruffin | 501(c)(3) | 2015 | $0 | $0 | 2025-12 |
| Lucky Paws Rescue Inc | Sumter | 501(c)(3) | 2022 | $0 | $0 | 2025-12 |
| Lukes Refuge | Cameron | 501(c)(3) | 2024 | $0 | $0 | 2025-12 |
| Lumber River Retriever Club Inc | Fort Mill | 501(c)(7) | 1999 | $0 | $0 | 2025-12 |
| Lumpkin Rescues | Columbia | 501(c)(3) | 2015 | $0 | $0 | 2025-12 |
| M A D Rescue Transport | Hollywood | 501(c)(3) | 2020 | $0 | $0 | 2025-05 |
| MSM Ranch Mini Equine Rescue | Anderson | 501(c)(3) | 2023 | $0 | $0 | 2025-12 |
| Magnolia Fawn Rescue Inc | Gray Court | 501(c)(3) | 2018 | $0 | $5,057 | 2024-12 |
| Magnolias Hope Kitten Rescue | Inman | 501(c)(3) | 2025 | $0 | $0 | 2025-12 |
| Majestic Wings Rescue | Cassatt | 501(c)(3) | 2017 | $0 | $0 | 2025-12 |
| Marion SC Shelter Friends | Mullins | 501(c)(3) | 2019 | $0 | $0 | 2025-12 |
| Marsh Tacky SC State Heritage Horse Retirement Center | Clover | 501(c)(3) | 2025 | $0 | $0 | 2026-01 |
| Maxs Primate Rescue | North Augusta | 501(c)(3) | 2026 | |||
| McGees Wildlife Rehab | Beaufort | 501(c)(3) | 2025 |
Every nonprofit in South Carolina
Read from the IRS Exempt Organizations Business Master File, updated by the IRS on October 24, 2026 and rebuilt here every morning. Revenue and assets are from each organization's latest filing as the IRS lists it; the IRS record is the official one. Organizations only: no people are named on these pages.