Data / Federal grants / PAR-27-135
Undiagnosed Diseases Network (UDN) Clinical and Data Coordinating Center
National Institutes of Health (Department of Health and Human Services) expects to post this opportunity around March 25, 2027, with applications due around May 25, 2027.
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Key facts
- Opportunity number
- PAR-27-135
- Status
- Forecast
- Posted
- September 10, 2026
- Closes
- May 25, 2027
- Cost sharing
- Not required
- Funding instrument
- Cooperative Agreement
- Category
- Health
- Assistance listing
- 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders
- Contact
- UDN Program Staff · [email protected] · Please contact via e-mail.
Who can apply
- City or township governments
- Independent school districts
- Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- Private institutions of higher education
- Public and State controlled institutions of higher education
- Others (see text field entitled "Additional Information on Eligibility" for clarification)
- Native American tribal governments (Federally recognized)
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- Special district governments
- Small businesses
- Public housing authorities/Indian housing authorities
- State governments
- County governments
- Native American tribal organizations (other than Federally recognized tribal governments)
- For profit organizations other than small businesses
Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations.
What the agency says
NINDS intends to support a new phase of the Undiagnosed Diseases Network (UDN) to advance diagnosis for individuals with previously undiagnosed diseases and undiagnosed diseases research. This phase would emphasize participant and family engagement, provider engagement, use of NIH and non-NIH resources, education, community engagement, research innovation and discovery, and broader implementation of advanced diagnostic approaches. The Network is expected to include a Clinical and Data Coordinating Center (CDCC), clinical Networks of Diagnostic Excellence, the NIH Undiagnosed Diseases Program (UDP), a Diagnostic Research Innovation Center, individuals with lived experience, patient advocacy organizations, NIH, and other stakeholders. NINDS anticipates supporting a CDCC to provide operational oversight and coordination for network activities including recruitment, participant support (e.g., patient navigation services, referring diagnosed participants to potential therapeutic options), protocol and regulatory management, data sharing, innovation in analytics, support for the systematic re-evaluation of unsolved UDN cases, collaboration, training, implementation science research to facilitate the transfer of successful UDN diagnostic approaches into mainstream medical care, and quality oversight and performance monitoring of the network. Applicants should demonstrate the infrastructure, staffing, governance, regulatory capacity, informatics systems, operational readiness, and stakeholder partnerships necessary to assume CDCC responsibilities with minimal start-up time following award. Applications are not being solicited at this time. This Forecast is being published to provide potential applicants time to plan, develop meaningful collaborations, and responsive projects.
Other open grants from the Department of Health and Human Services
| Opportunity | Status | Closes | Award ceiling | Total funding | Record |
|---|---|---|---|---|---|
| Long-term health outcomes of people living with spina bifida CDC-RFA-DD-26-0222 | Open | Oct 26 | $300,000 | $3,000,000 | grants.gov |
| GREGoRi Data Coordination and Outreach Center (U01, Clinical Trials Not Allowed) RFA-HG-27-011 | Open | Oct 30 | $1,250,000 | $2,000,000 | grants.gov |
| GREGoRi Innovation Projects (U01 Clinical Trial Optional) RFA-HG-27-013 | Open | Oct 30 | $500,000 | $7,500,000 | grants.gov |
| GREGoRi Technology Integration Center (U01, Clinical Trials Optional) RFA-HG-27-012 | Open | Oct 30 | $2,250,000 | $3,000,000 | grants.gov |
| HEAL Initiative: Whole Joint Health Program (R61/R33 Clinical Trial Required) PAR-27-045 | Open | Oct 30 | grants.gov | ||
| Clinical Observational (CO) Studies in Musculoskeletal, Rheumatic, and Skin Diseases (R01 Clinical Trial Not Allowed) PAR-24-280 | Open | Nov 2 | grants.gov |
All grants open to City or township governments · All grants open to Independent school districts · All grants open to Nonprofits without 501(c)(3) status · Everything closing in May 2027
Read from the Grants.gov API, last updated 2026-10-23. The agency's notice on Grants.gov is the official record; check it before you apply.