Data / Federal grants / RFA-RM-28-014
Somatic Mosaicism across Human Tissues (SMaHT) Program: Tissue Procurement Center (R24 Clinical Trial Not Allowed)
National Institutes of Health (Department of Health and Human Services) expects to post this opportunity around May 1, 2027, with applications due around July 1, 2027.
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Key facts
- Opportunity number
- RFA-RM-28-014
- Status
- Forecast
- Posted
- September 14, 2026
- Closes
- July 1, 2027
- Cost sharing
- Not required
- Funding instrument
- Grant
- Category
- Health
- Assistance listing
- 93.310 Trans-NIH Research Support
- Contact
- SMaHT Program · [email protected] · Please contact via e-mail.
Who can apply
- State governments
- Private institutions of higher education
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- Others (see text field entitled "Additional Information on Eligibility" for clarification)
- County governments
- Native American tribal organizations (other than Federally recognized tribal governments)
- City or township governments
- Special district governments
- Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- Public housing authorities/Indian housing authorities
- Public and State controlled institutions of higher education
- Native American tribal governments (Federally recognized)
- Small businesses
- Independent school districts
- For profit organizations other than small businesses
Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).
What the agency says
The purpose of the Somatic Mosaicism across Human Tissues (SMaHT) Network is to advance the discovery of biological processes and disease mechanisms mediated by somatic mutations in human tissues. Since 2023, the program has generated multi-omic somatic mutation datasets from a standardized set of human tissues spanning all three germ layers. Building on the Stage 1 foundation, the NIH intends to issue a Notice of Funding Opportunity (NOFO) seeking support for the SMaHT Tissue Procurement Center (TPC) initiative. The TPC will enable functional analyses of these healthy and clinically relevant tissue samples, providing critical resources to support characterization of somatic mosaicism and its role in human biology and disease. The Tissue Procurement Center will support the Network by collecting, processing, storing, and rapidly distributing high-quality, well-characterized human tissue specimens. Building on the 150 healthy donors enrolled during Stage 1, the TPC will procure tissues from at least 50 additional healthy donors, bringing the total to 200. The TPC will also collect up to 10 special tissue cohorts. The special tissue cohorts may include: tissues that can be grown in culture, tissues that are of high interest for somatic mosaicism studies, clinically relevant samples, organs that require special handling procedures, and other relevant samples. Awardee will collaborate with other SMaHT Stage 2 initiatives to ensure that the samples are sufficient and useful for running production level assays within the program.
Other open grants from the Department of Health and Human Services
| Opportunity | Status | Closes | Award ceiling | Total funding | Record |
|---|---|---|---|---|---|
| Long-term health outcomes of people living with spina bifida CDC-RFA-DD-26-0222 | Open | Oct 26 | $300,000 | $3,000,000 | grants.gov |
| GREGoRi Data Coordination and Outreach Center (U01, Clinical Trials Not Allowed) RFA-HG-27-011 | Open | Oct 30 | $1,250,000 | $2,000,000 | grants.gov |
| GREGoRi Innovation Projects (U01 Clinical Trial Optional) RFA-HG-27-013 | Open | Oct 30 | $500,000 | $7,500,000 | grants.gov |
| GREGoRi Technology Integration Center (U01, Clinical Trials Optional) RFA-HG-27-012 | Open | Oct 30 | $2,250,000 | $3,000,000 | grants.gov |
| HEAL Initiative: Whole Joint Health Program (R61/R33 Clinical Trial Required) PAR-27-045 | Open | Oct 30 | grants.gov | ||
| Clinical Observational (CO) Studies in Musculoskeletal, Rheumatic, and Skin Diseases (R01 Clinical Trial Not Allowed) PAR-24-280 | Open | Nov 2 | grants.gov |
All grants open to State governments · All grants open to Private colleges and universities · All grants open to Nonprofits (501(c)(3)) · Everything closing in July 2027
Read from the Grants.gov API, last updated 2026-10-23. The agency's notice on Grants.gov is the official record; check it before you apply.