Data / Federal grants / PAR-27-127
Silvio O. Conte Centers for Basic Neuroscience or Translational Mental Health Research (P50 Clinical Trial Optional)
National Institutes of Health (Department of Health and Human Services) is accepting applications until May 25, 2028.
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Key facts
- Opportunity number
- PAR-27-127
- Status
- Posted, open
- Posted
- September 1, 2026
- Closes
- May 25, 2028
- Cost sharing
- Not required
- Funding instrument
- Grant
- Category
- Health
- Assistance listing
- 93.242 Mental Health Research Grants
- Contact
- National Institutes of Health · [email protected] · 301-402-2541
Who can apply
- City or township governments
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- Native American tribal governments (Federally recognized)
- Special district governments
- For profit organizations other than small businesses
- Others (see text field entitled "Additional Information on Eligibility" for clarification)
- Native American tribal organizations (other than Federally recognized tribal governments)
- State governments
- Public housing authorities/Indian housing authorities
- Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- Small businesses
- County governments
- Private institutions of higher education
- Public and State controlled institutions of higher education
- Independent school districts
Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organization) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
What the agency says
This notice of funding opportunity (NOFO) encourages applications for Silvio O. Conte Centers for Basic Neuroscience or Translational Mental Health Research. The National Institute of Mental Health (NIMH) seeks teams of integrative researchers working at different levels of analysis and employing novel, and creative experimental approaches to address high-risk, high-impact questions with the primary objectives of: (a) advancing basic brain and behavior research that will uncover underlying mechanisms that could provide the foundation for understanding mental disorders; (b) supporting the integration and translation of basic and clinical neuroscience research on severe mental illnesses; (c) advancing our understanding of the neurobehavioral mechanisms and trajectories of psychopathology that begin in development. This program is intended only for projects that could not be achieved using other, more standard grant mechanisms.
Other open grants from the Department of Health and Human Services
| Opportunity | Status | Closes | Award ceiling | Total funding | Record |
|---|---|---|---|---|---|
| Long-term health outcomes of people living with spina bifida CDC-RFA-DD-26-0222 | Open | Oct 26 | $300,000 | $3,000,000 | grants.gov |
| GREGoRi Data Coordination and Outreach Center (U01, Clinical Trials Not Allowed) RFA-HG-27-011 | Open | Oct 30 | $1,250,000 | $2,000,000 | grants.gov |
| GREGoRi Innovation Projects (U01 Clinical Trial Optional) RFA-HG-27-013 | Open | Oct 30 | $500,000 | $7,500,000 | grants.gov |
| GREGoRi Technology Integration Center (U01, Clinical Trials Optional) RFA-HG-27-012 | Open | Oct 30 | $2,250,000 | $3,000,000 | grants.gov |
| HEAL Initiative: Whole Joint Health Program (R61/R33 Clinical Trial Required) PAR-27-045 | Open | Oct 30 | grants.gov | ||
| Clinical Observational (CO) Studies in Musculoskeletal, Rheumatic, and Skin Diseases (R01 Clinical Trial Not Allowed) PAR-24-280 | Open | Nov 2 | grants.gov |
All grants open to City or township governments · All grants open to Nonprofits (501(c)(3)) · All grants open to Tribal governments · Everything closing in May 2028
Read from the Grants.gov API, last updated 2026-10-24. The agency's notice on Grants.gov is the official record; check it before you apply.