Data / Federal grants / RFA-AR-26-006
Restoring Joint Health and Function to Reduce Pain (RE-JOIN) 2.0
National Institutes of Health (Department of Health and Human Services) expects to post this opportunity around October 1, 2026, with applications due around December 1, 2026. It lists 8 awards expected.
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Key facts
- Opportunity number
- RFA-AR-26-006
- Status
- Forecast
- Posted
- January 22, 2026
- Closes
- December 1, 2026
- Expected awards
- 8
- Cost sharing
- Not required
- Funding instrument
- Cooperative Agreement
- Category
- Health
- Assistance listing
- 93.846 Arthritis, Musculoskeletal and Skin Diseases Research
- Contact
- National Institute of Arthritis and Musculoskeletal and Skin Diseases · [email protected] · Please contact via e-mail.
Who can apply
- Public and State controlled institutions of higher education
- Small businesses
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- Others (see text field entitled "Additional Information on Eligibility" for clarification)
- Independent school districts
- Public housing authorities/Indian housing authorities
- For profit organizations other than small businesses
- City or township governments
- State governments
- Private institutions of higher education
- County governments
- Native American tribal organizations (other than Federally recognized tribal governments)
- Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- Native American tribal governments (Federally recognized)
- Special district governments
Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).
What the agency says
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), in conjunction with other NIH Institutes and Centers (ICs) as a part of the congressionally mandated NIH Helping to End Addiction Long Term (HEAL) initiative intends to publish a Notice of Funding Opportunity (NOFO) to leverage and accelerate the progress achieved in the Restoring Joint Health and Function to Reduce Pain (RE-JOIN) Consortium. The NOFO aims to more fully refine and map the innervation of the different articular and peri-articular tissues that collectively form the joint (including bone, cartilage, synovium, joint capsule, ligament, tendon, fascia and muscle), by sensory neurons that mediate the sensation of pain. The NOFO seeks to expand initial and ongoing efforts by: Enhancing clinical pain phenotyping with multimodal profiling of new and expanded patient samples across life span and disease conditions (i.e., other musculoskeletal and/or rheumatic conditions associated with joint pain beyond knee and temporomandibular joint (TMJ)). Expanding to new preclinical and New Approach Methodologies (NAMs) in modeling joint disease. Preclinical testing of novel joint-targeted candidates identified in RE-JOIN 1.0. Focusing on peri-articular tissues in joint pain, such as vasculature, synovium, adipose, myofascial tissue, etc. Prioritizing secondary analysis of datasets and/or validation of methods and approaches in human samples. Improve data integration by developing/enhancing joint atlases that will enable integration of imaging and molecular datasets. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful multidisciplinary collaborations and responsive projects. Investigators with expertise and insights in neurobiology, pain science, data science, orthopedics, rheumatic disease, etc. are encouraged to consider applying for this NOFO.
Other open grants from the Department of Health and Human Services
| Opportunity | Status | Closes | Award ceiling | Total funding | Record |
|---|---|---|---|---|---|
| Long-term health outcomes of people living with spina bifida CDC-RFA-DD-26-0222 | Open | Oct 26 | $300,000 | $3,000,000 | grants.gov |
| GREGoRi Data Coordination and Outreach Center (U01, Clinical Trials Not Allowed) RFA-HG-27-011 | Open | Oct 30 | $1,250,000 | $2,000,000 | grants.gov |
| GREGoRi Innovation Projects (U01 Clinical Trial Optional) RFA-HG-27-013 | Open | Oct 30 | $500,000 | $7,500,000 | grants.gov |
| GREGoRi Technology Integration Center (U01, Clinical Trials Optional) RFA-HG-27-012 | Open | Oct 30 | $2,250,000 | $3,000,000 | grants.gov |
| HEAL Initiative: Whole Joint Health Program (R61/R33 Clinical Trial Required) PAR-27-045 | Open | Oct 30 | grants.gov | ||
| Clinical Observational (CO) Studies in Musculoskeletal, Rheumatic, and Skin Diseases (R01 Clinical Trial Not Allowed) PAR-24-280 | Open | Nov 2 | grants.gov |
All grants open to Public colleges and universities · All grants open to Small businesses · All grants open to Nonprofits (501(c)(3)) · Everything closing in December 2026
Read from the Grants.gov API, last updated 2026-10-23. The agency's notice on Grants.gov is the official record; check it before you apply.