Data / Federal grants / RFA-AI-28-014
Precision and Systems Biology to Uncover the Link Between Chronic and Infectious Diseases
National Institutes of Health (Department of Health and Human Services) expects to post this opportunity around November 6, 2026, with applications due around January 22, 2027. It lists 10 awards expected, $17.5 million in total.
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Key facts
- Opportunity number
- RFA-AI-28-014
- Status
- Forecast
- Posted
- June 24, 2026
- Closes
- January 22, 2027
- Expected awards
- 10
- Total funding
- $17,500,000
- Cost sharing
- Not required
- Funding instrument
- Cooperative Agreement
- Category
- Health
- Assistance listing
- 93.855 Allergy and Infectious Diseases Research; 93.866 Aging Research
- Contact
- NIAID OGAT (Division of Microbiology and Infectious Diseases) · [email protected] · Please contact via email.
Who can apply
- State governments
- Independent school districts
- Public housing authorities/Indian housing authorities
- Small businesses
- Native American tribal organizations (other than Federally recognized tribal governments)
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- For profit organizations other than small businesses
- Others (see text field entitled "Additional Information on Eligibility" for clarification)
- County governments
- Special district governments
- City or township governments
- Native American tribal governments (Federally recognized)
- Private institutions of higher education
- Public and State controlled institutions of higher education
Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).
What the agency says
The National Institute of Allergy and Infectious Diseases (NIAID) seeks to advance its mission by supporting multidisciplinary, consortium-based research using precision systems biology approaches to uncover links among chronic illnesses, infectious diseases and microbiomes. There is an urgent scientific and clinical need to understand the pathways by which infections lead to chronic lifelong health issues or alternatively, how long-term illnesses might predispose or exacerbate acute infections. The objective is to harness cutting-edge technologies along with longitudinal patient cohorts and biobank data for comprehensive analysis of genetic, environmental, and lifestyle factors leading to advances in prevention and treatment strategies for both chronic and infectious diseases. The cutting-edge technologies may include multi-omics, computational modeling, artificial intelligence, organoid-based validation systems, and integration of real-world data, alongside improved access to digital health records and advanced clinical informatics tools. The goal is to generate meaningful insights into disease progression and host-pathogen interactions. Grant authorities that allow NIAID to forecast this opportunity are as follows: Sections 301 and 405 of the Public Health Service Act as amended (42 USC 241 and 284) and under Federal Regulations 42 CFR Part 52 and 2 CFR Part 200.
Other open grants from the Department of Health and Human Services
| Opportunity | Status | Closes | Award ceiling | Total funding | Record |
|---|---|---|---|---|---|
| Long-term health outcomes of people living with spina bifida CDC-RFA-DD-26-0222 | Open | Oct 26 | $300,000 | $3,000,000 | grants.gov |
| GREGoRi Data Coordination and Outreach Center (U01, Clinical Trials Not Allowed) RFA-HG-27-011 | Open | Oct 30 | $1,250,000 | $2,000,000 | grants.gov |
| GREGoRi Innovation Projects (U01 Clinical Trial Optional) RFA-HG-27-013 | Open | Oct 30 | $500,000 | $7,500,000 | grants.gov |
| GREGoRi Technology Integration Center (U01, Clinical Trials Optional) RFA-HG-27-012 | Open | Oct 30 | $2,250,000 | $3,000,000 | grants.gov |
| HEAL Initiative: Whole Joint Health Program (R61/R33 Clinical Trial Required) PAR-27-045 | Open | Oct 30 | grants.gov | ||
| Clinical Observational (CO) Studies in Musculoskeletal, Rheumatic, and Skin Diseases (R01 Clinical Trial Not Allowed) PAR-24-280 | Open | Nov 2 | grants.gov |
All grants open to State governments · All grants open to Independent school districts · All grants open to Public housing authorities/Indian housing authorities · Everything closing in January 2027
Read from the Grants.gov API, last updated 2026-10-23. The agency's notice on Grants.gov is the official record; check it before you apply.