Data / Federal grants / RFA-OH-27-049

NIOSH Centers of Excellence for Total Worker Health® (U19)

Centers for Disease Control and Prevention - ERA (Department of Health and Human Services) expects to post this opportunity around November 16, 2026, with applications due around February 26, 2027. It lists awards of up to $1.4 million, 10 awards expected, $58.5 million in total.

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Key facts

Opportunity number: RFA-OH-27-049
Status: Forecast
Posted: July 28, 2026
Closes: February 26, 2027
Award ceiling: $1,400,000
Award floor: $500,000
Expected awards: 10
Total funding: $58,500,000
Cost sharing: Not required
Funding instrument: Cooperative Agreement
Category: Health
Assistance listing: 93.262 Occupational Safety and Health Program
Contact: Maria Lioce, MD, Scientific Program Official · [email protected] · 404-498-2575

Who can apply

Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Private institutions of higher education
Native American tribal organizations (other than Federally recognized tribal governments)
Independent school districts
Native American tribal governments (Federally recognized)
For profit organizations other than small businesses
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
County governments
Public and State controlled institutions of higher education
Special district governments
State governments
Public housing authorities/Indian housing authorities
Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled "Additional Information on Eligibility"
City or township governments
Small businesses

Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the HHS Grants Policy Statement, are not allowed.

What the agency says

PURPOSE NIOSH intends to support the Centers of Excellence in Total Worker Health® (TWH). These Centers will conduct rigorous research and translation activities to prevent harmful exposures, improve working conditions, and advance worker well-being. The Centers will develop practical, scalable solutions for employers and workers. All projects must use the NIOSH Worker Well-Being Questionnaire (WellBQ) and share data with the HERO Worker Well-Being Clearinghouse. Large Research Projects require economic evaluation. PRIORITY AREAS • High-risk occupations: First responders, vehicle mechanics, and technicians, with emphasis on occupational exposures, related health risks, and prevention strategies • Young workers, SMEs • Chronic disease • Mental health, stress • Substance use disorder • Artificial intelligence (AI), digital technologies This is a multi-component NOFO. COMPONENT STRUCTURE Percentages indicate maximum share of total budget. Overall Component (Required) Provides Center leadership and integration. Applicants should show strong coordination, scientific direction, and alignment across projects. Administration, Evaluation, and Emerging Issues Core (Required; up to 15%) Supports management and Center-wide evaluation. Applicants should describe oversight, data governance, and quality assurance.Optional activities include emerging issues and shared research resources. Outreach, Dissemination, and Impact Core (Required; up to 15%) Supports communication, worker/employer engagement, training, translation, implementation, and dissemination strategies. Research Projects (Required; about 60 to 70%) Includes all research activities. Applicants may propose a mix of projects. Research project distinctions are based on scope and complexity rather than cost. Projects should demonstrate scientific rigor and potential for sustained impact. Small Research Projects (Required; at least one project; up to 3 years) Exploratory, feasibility, early-stage intervention, surveillance, or measurement studies. Priority areas: high-risk occupations, young workers, SMEs. Should show innovation and potential to expand. Large Research Projects (Required; at least one project; up to 5 years) Multiyear etiologic, mechanistic, intervention, or translational studies. Priority areas: chronic disease, mental health, substance use disorder. Economic evaluation is required. Projects should include strong design and analytic plans. Pilot/Feasibility Program (Optional; 12–18 months) Short-term studies generating preliminary data or testing AI/digital technology approaches.

The notice on Grants.gov

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All grants open to Nonprofits (501(c)(3)) · All grants open to Private colleges and universities · All grants open to Tribal organizations · Everything closing in February 2027

Read from the Grants.gov API, last updated 2026-10-24. The agency's notice on Grants.gov is the official record; check it before you apply.