Data / Federal grants / PAR-27-032

Maximizing Investigators’ Research Award (MIRA) for Early Stage Investigators (ESI)

National Institutes of Health (Department of Health and Human Services) is accepting applications until February 6, 2029.

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Key facts

Opportunity number: PAR-27-032
Status: Posted, open
Posted: May 12, 2026
Closes: February 6, 2029
Cost sharing: Not required
Funding instrument: Grant
Category: Health
Assistance listing: 93.859 Biomedical Research and Research Training; None None
Contact: National Institutes of Health · [email protected] · 301-402-2541

Who can apply

Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Others (see text field entitled "Additional Information on Eligibility" for clarification)
Independent school districts
Special district governments
City or township governments
Public housing authorities/Indian housing authorities
Native American tribal governments (Federally recognized)
Native American tribal organizations (other than Federally recognized tribal governments)
State governments
For profit organizations other than small businesses
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
Small businesses
Public and State controlled institutions of higher education
Private institutions of higher education
County governments

Refer to the Eligibility section in the NOFO for additional information on eligibility.Foreign institutions: Foreign components, as defined in the NIH Grants Policy Statement, are allowed.These types of organizations are not eligible to apply: Non-domestic (non-U.S.) entities (foreign institutions), Non-domestic (non-U.S.) components of U.S. organizations.

What the agency says

The Maximizing Investigators' Research Award (MIRA) for Early Stage Investigators (ESIs) provides support for ESIs with a program of research that aligns with the NIGMS mission.MIRA distributes funding among promising investigators across the country. The goal is to boost scientific productivity and the chances for important breakthroughs.Through this program, investigators can:Receive independent research funding early to start and sustain strong research careers.Explore new, unique research areas in the NIGMS mission.Take on ambitious, creative projects.Shift focus to include emerging techniques and technologies as needed.Devote more time to mentoring trainees in a stable research environment.

The notice on Grants.gov

Other open grants from the Department of Health and Human Services

Opportunity	Status	Closes	Award ceiling	Total funding	Record
Long-term health outcomes of people living with spina bifida CDC-RFA-DD-26-0222	Open	Oct 26	$300,000	$3,000,000	grants.gov
GREGoRi Data Coordination and Outreach Center (U01, Clinical Trials Not Allowed) RFA-HG-27-011	Open	Oct 30	$1,250,000	$2,000,000	grants.gov
GREGoRi Innovation Projects (U01 Clinical Trial Optional) RFA-HG-27-013	Open	Oct 30	$500,000	$7,500,000	grants.gov
GREGoRi Technology Integration Center (U01, Clinical Trials Optional) RFA-HG-27-012	Open	Oct 30	$2,250,000	$3,000,000	grants.gov
HEAL Initiative: Whole Joint Health Program (R61/R33 Clinical Trial Required) PAR-27-045	Open	Oct 30			grants.gov
Clinical Observational (CO) Studies in Musculoskeletal, Rheumatic, and Skin Diseases (R01 Clinical Trial Not Allowed) PAR-24-280	Open	Nov 2			grants.gov

All grants open to Nonprofits (501(c)(3)) · All grants open to Independent school districts · All grants open to Special district governments · Everything closing in February 2029

Read from the Grants.gov API, last updated 2026-10-23. The agency's notice on Grants.gov is the official record; check it before you apply.