Data / Federal grants / RFA-HG-28-005
Limited Competition: The NHGRI Analysis, Visualization, and Informatics Lab-space (AnVIL) (U54 Clinical Trial Not Allowed)
National Institutes of Health (Department of Health and Human Services) expects to post this opportunity around February 1, 2027, with applications due around May 25, 2027. It lists 1 award expected, $8 million in total.
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Key facts
- Opportunity number
- RFA-HG-28-005
- Status
- Forecast
- Posted
- June 2, 2026
- Closes
- May 25, 2027
- Expected awards
- 1
- Total funding
- $8,000,000
- Cost sharing
- Not required
- Funding instrument
- Cooperative Agreement
- Category
- Health
- Assistance listing
- 93.172 Human Genome Research
- Contact
- Office of the Director / Office of Genomic Data Science · [email protected] · Please contact via e-mail.
Who can apply
- Public and State controlled institutions of higher education
- For profit organizations other than small businesses
- City or township governments
- County governments
- State governments
- Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- Private institutions of higher education
- Public housing authorities/Indian housing authorities
- Native American tribal organizations (other than Federally recognized tribal governments)
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- Small businesses
- Special district governments
- Others (see text field entitled "Additional Information on Eligibility" for clarification)
- Independent school districts
- Native American tribal governments (Federally recognized)
Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).
What the agency says
The National Human Genome Research Institute (NHGRI) intends to issue a Notice of Funding Opportunity (NOFO) to support a limited competition renewal of the Analysis, Visualization, and Informatics Lab-space (AnVIL) program. AnVIL is a secure, cloud-based platform that enables researchers to access, share, and analyze large-scale genomic datasets without relying on local infrastructure. Currently, AnVIL hosts more than 5 petabytes of data from nearly 300,000 research participants, providing a robust environment for reproducible, cloud-native genomic research. The renewed program will continue to advance AnVIL as a community resource grounded in FAIR (Findable, Accessible, Interoperable, and Reusable) principles. Key priorities include enhancing scalability; strengthening interoperability across a federated NIH data ecosystem; and maintaining rigorous security aligned with the Research Authentication Service (RAS) and NIH controlled-access data repositories and access management systems (CADR) requirements (see NOT‑OD‑25‑159). The renewal will also support integration of emerging data types and computational tools, including infrastructure for developing and running AI-based methods and complex analysis workflows. In addition to platform development, the program will expand training and outreach to help researchers effectively use AnVIL’s multimodal datasets and reproducible analysis capabilities. By connecting secure data access, analytical tools, and workforce development, the renewed AnVIL program aims to accelerate discovery across the research lifecycle and strengthen the genomics community’s capacity for clinical and translational science. This Notice is being provided to allow potential applicants sufficient time to develop responsive applications. The NOFO is expected to be published in 2027 with an anticipated application due date in 2027. This NOFO will utilize the U54 activity code. This is a Forecast for a limited competition that will invite application(s) from eligible organization(s) to apply. Please see Eligibility Section for additional information. In accordance with NIH standard peer-review processes, the application(s) will be peer-reviewed, and only meritorious application(s) will be considered for funding.
Other open grants from the Department of Health and Human Services
| Opportunity | Status | Closes | Award ceiling | Total funding | Record |
|---|---|---|---|---|---|
| Long-term health outcomes of people living with spina bifida CDC-RFA-DD-26-0222 | Open | Oct 26 | $300,000 | $3,000,000 | grants.gov |
| GREGoRi Data Coordination and Outreach Center (U01, Clinical Trials Not Allowed) RFA-HG-27-011 | Open | Oct 30 | $1,250,000 | $2,000,000 | grants.gov |
| GREGoRi Innovation Projects (U01 Clinical Trial Optional) RFA-HG-27-013 | Open | Oct 30 | $500,000 | $7,500,000 | grants.gov |
| GREGoRi Technology Integration Center (U01, Clinical Trials Optional) RFA-HG-27-012 | Open | Oct 30 | $2,250,000 | $3,000,000 | grants.gov |
| HEAL Initiative: Whole Joint Health Program (R61/R33 Clinical Trial Required) PAR-27-045 | Open | Oct 30 | grants.gov | ||
| Clinical Observational (CO) Studies in Musculoskeletal, Rheumatic, and Skin Diseases (R01 Clinical Trial Not Allowed) PAR-24-280 | Open | Nov 2 | grants.gov |
All grants open to Public colleges and universities · All grants open to For profit organizations other than small businesses · All grants open to City or township governments · Everything closing in May 2027
Read from the Grants.gov API, last updated 2026-10-23. The agency's notice on Grants.gov is the official record; check it before you apply.